

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pyrimidine nucleobase catabolic process (GO:0006208) | 7.53891032 |
| 2 | layer formation in cerebral cortex (GO:0021819) | 6.33060132 |
| 3 | nucleobase catabolic process (GO:0046113) | 5.82720523 |
| 4 | cell migration in hindbrain (GO:0021535) | 5.58540890 |
| 5 | response to pheromone (GO:0019236) | 5.36834092 |
| 6 | locomotory exploration behavior (GO:0035641) | 5.23964047 |
| 7 | positive regulation of synapse maturation (GO:0090129) | 4.94931872 |
| 8 | dendritic spine morphogenesis (GO:0060997) | 4.85934014 |
| 9 | dendrite morphogenesis (GO:0048813) | 4.85177143 |
| 10 | central nervous system projection neuron axonogenesis (GO:0021952) | 4.79263756 |
| 11 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.61269989 |
| 12 | presynaptic membrane organization (GO:0097090) | 4.57723245 |
| 13 | presynaptic membrane assembly (GO:0097105) | 4.56975807 |
| 14 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.56275600 |
| 15 | axonal fasciculation (GO:0007413) | 4.55157564 |
| 16 | cerebellar granule cell differentiation (GO:0021707) | 4.53336891 |
| 17 | vocalization behavior (GO:0071625) | 4.50373808 |
| 18 | synaptic vesicle maturation (GO:0016188) | 4.43857486 |
| 19 | neuron recognition (GO:0008038) | 4.31350486 |
| 20 | neuron cell-cell adhesion (GO:0007158) | 4.29029124 |
| 21 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.18216587 |
| 22 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.09573975 |
| 23 | negative regulation of microtubule polymerization (GO:0031115) | 4.05939473 |
| 24 | regulation of synapse structural plasticity (GO:0051823) | 4.05371023 |
| 25 | exploration behavior (GO:0035640) | 4.03122992 |
| 26 | establishment of nucleus localization (GO:0040023) | 4.01345896 |
| 27 | protein localization to synapse (GO:0035418) | 3.93058357 |
| 28 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.92333604 |
| 29 | mitochondrion transport along microtubule (GO:0047497) | 3.90712592 |
| 30 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.90712592 |
| 31 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.90583086 |
| 32 | behavioral response to nicotine (GO:0035095) | 3.89588796 |
| 33 | glial cell proliferation (GO:0014009) | 3.79118289 |
| 34 | establishment of mitochondrion localization (GO:0051654) | 3.68082099 |
| 35 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.65645133 |
| 36 | gamma-aminobutyric acid transport (GO:0015812) | 3.64149388 |
| 37 | axon extension (GO:0048675) | 3.61024269 |
| 38 | regulation of synapse maturation (GO:0090128) | 3.60610501 |
| 39 | synaptic vesicle exocytosis (GO:0016079) | 3.59480774 |
| 40 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.57576775 |
| 41 | central nervous system neuron axonogenesis (GO:0021955) | 3.55190607 |
| 42 | negative regulation of catenin import into nucleus (GO:0035414) | 3.54849217 |
| 43 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.47220487 |
| 44 | cell differentiation in hindbrain (GO:0021533) | 3.46996634 |
| 45 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.45465236 |
| 46 | cell communication by electrical coupling (GO:0010644) | 3.45126089 |
| 47 | neurotransmitter secretion (GO:0007269) | 3.41423774 |
| 48 | cerebellum development (GO:0021549) | 3.37649711 |
| 49 | clathrin coat assembly (GO:0048268) | 3.36076477 |
| 50 | glutamate receptor signaling pathway (GO:0007215) | 3.35559081 |
| 51 | postsynaptic membrane organization (GO:0001941) | 3.33251651 |
| 52 | glutamate secretion (GO:0014047) | 3.29020705 |
| 53 | mechanosensory behavior (GO:0007638) | 3.25653953 |
| 54 | synaptic transmission, glutamatergic (GO:0035249) | 3.25482345 |
| 55 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.25243121 |
| 56 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.25209912 |
| 57 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.25090627 |
| 58 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.25041117 |
| 59 | cerebellar Purkinje cell layer development (GO:0021680) | 3.23968387 |
| 60 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.23469629 |
| 61 | neuromuscular process controlling balance (GO:0050885) | 3.22665042 |
| 62 | spinal cord development (GO:0021510) | 3.18594618 |
| 63 | hippocampus development (GO:0021766) | 3.18333878 |
| 64 | neuron projection extension (GO:1990138) | 3.17088021 |
| 65 | response to auditory stimulus (GO:0010996) | 3.16611603 |
| 66 | auditory behavior (GO:0031223) | 3.15195056 |
| 67 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.13521245 |
| 68 | membrane depolarization during action potential (GO:0086010) | 3.05643180 |
| 69 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.04389378 |
| 70 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.04389378 |
| 71 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.04389378 |
| 72 | dendrite development (GO:0016358) | 3.04260418 |
| 73 | neuromuscular synaptic transmission (GO:0007274) | 3.03541843 |
| 74 | positive regulation of axon extension (GO:0045773) | 3.03226330 |
| 75 | positive regulation of synapse assembly (GO:0051965) | 3.02742649 |
| 76 | regulation of synaptic vesicle transport (GO:1902803) | 3.01058883 |
| 77 | collecting duct development (GO:0072044) | 3.00895716 |
| 78 | prepulse inhibition (GO:0060134) | 3.00273380 |
| 79 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.99097256 |
| 80 | forebrain neuron differentiation (GO:0021879) | 2.98995352 |
| 81 | adult walking behavior (GO:0007628) | 2.98730289 |
| 82 | positive regulation of dendritic spine development (GO:0060999) | 2.97027198 |
| 83 | regulation of respiratory system process (GO:0044065) | 2.96764241 |
| 84 | hindbrain development (GO:0030902) | 2.94862138 |
| 85 | regulation of axon extension (GO:0030516) | 2.94425062 |
| 86 | neuron migration (GO:0001764) | 2.94288492 |
| 87 | proline transport (GO:0015824) | 2.93788651 |
| 88 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.92644725 |
| 89 | neuron projection morphogenesis (GO:0048812) | 2.91335564 |
| 90 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.91172819 |
| 91 | short-term memory (GO:0007614) | 2.90346886 |
| 92 | activation of protein kinase A activity (GO:0034199) | 2.89648629 |
| 93 | sodium ion export (GO:0071436) | 2.88731403 |
| 94 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.88581683 |
| 95 | retinal ganglion cell axon guidance (GO:0031290) | 2.88213552 |
| 96 | neurofilament cytoskeleton organization (GO:0060052) | 2.87523379 |
| 97 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.87069738 |
| 98 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.86882049 |
| 99 | negative regulation of axon extension (GO:0030517) | 2.85657190 |
| 100 | dendritic spine organization (GO:0097061) | 2.84032885 |
| 101 | neuronal action potential propagation (GO:0019227) | 2.80243233 |
| 102 | regulation of synapse organization (GO:0050807) | 2.80077201 |
| 103 | synapse assembly (GO:0007416) | 2.79918051 |
| 104 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.79453266 |
| 105 | positive regulation of membrane potential (GO:0045838) | 2.78596007 |
| 106 | negative regulation of axonogenesis (GO:0050771) | 2.77816931 |
| 107 | organelle transport along microtubule (GO:0072384) | 2.77418187 |
| 108 | synaptic vesicle endocytosis (GO:0048488) | 2.77017574 |
| 109 | synapse organization (GO:0050808) | 2.76478049 |
| 110 | cerebral cortex neuron differentiation (GO:0021895) | 2.76326026 |
| 111 | regulation of gene silencing by miRNA (GO:0060964) | 2.76178234 |
| 112 | regulation of gene silencing by RNA (GO:0060966) | 2.76178234 |
| 113 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.76178234 |
| 114 | long-term memory (GO:0007616) | 2.76055451 |
| 115 | neuron-neuron synaptic transmission (GO:0007270) | 2.76019770 |
| 116 | cranial nerve morphogenesis (GO:0021602) | 2.73656579 |
| 117 | neuronal ion channel clustering (GO:0045161) | 2.73551322 |
| 118 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.72433511 |
| 119 | regulation of postsynaptic membrane potential (GO:0060078) | 2.72378096 |
| 120 | regulation of neuron migration (GO:2001222) | 2.72091299 |
| 121 | regulation of ARF protein signal transduction (GO:0032012) | 2.71526520 |
| 122 | positive regulation of filopodium assembly (GO:0051491) | 2.71226647 |
| 123 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.69524417 |
| 124 | regulation of microtubule polymerization (GO:0031113) | 2.68356500 |
| 125 | generation of neurons (GO:0048699) | 2.68144861 |
| 126 | nonmotile primary cilium assembly (GO:0035058) | 2.68009238 |
| 127 | regulation of extent of cell growth (GO:0061387) | 2.67473312 |
| 128 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.66724199 |
| 129 | membrane depolarization (GO:0051899) | 2.66463549 |
| 130 | camera-type eye morphogenesis (GO:0048593) | 2.65682048 |
| 131 | transmission of nerve impulse (GO:0019226) | 2.65003574 |
| 132 | axonogenesis (GO:0007409) | 2.64301155 |
| 133 | retina layer formation (GO:0010842) | 2.63309573 |
| 134 | innervation (GO:0060384) | 2.61956303 |
| 135 | positive regulation of microtubule polymerization or depolymerization (GO:0031112) | 2.56702178 |
| 136 | sympathetic nervous system development (GO:0048485) | 2.56055193 |
| 137 | apical protein localization (GO:0045176) | 2.55943938 |
| 138 | regulation of respiratory gaseous exchange (GO:0043576) | 2.54406488 |
| 139 | regulation of synapse assembly (GO:0051963) | 2.54225443 |
| 140 | membrane hyperpolarization (GO:0060081) | 2.52501149 |
| 141 | startle response (GO:0001964) | 2.52023030 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.18144990 |
| 2 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 3.02207657 |
| 3 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 3.00380187 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.80644654 |
| 5 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.67858019 |
| 6 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.67858019 |
| 7 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.62834948 |
| 8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.57018575 |
| 9 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.54105331 |
| 10 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.47930312 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.46557087 |
| 12 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.46505134 |
| 13 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.44656583 |
| 14 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.32315620 |
| 15 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.29613288 |
| 16 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.26797465 |
| 17 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.26609724 |
| 18 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.21090788 |
| 19 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.19491575 |
| 20 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.17537118 |
| 21 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.14478366 |
| 22 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.11633504 |
| 23 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.10822505 |
| 24 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.10300670 |
| 25 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.02172765 |
| 26 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.00467309 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.99241706 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.98504936 |
| 29 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.95716096 |
| 30 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.91301615 |
| 31 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.88105464 |
| 32 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.87434883 |
| 33 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.85733135 |
| 34 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.77272657 |
| 35 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.74114278 |
| 36 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.73656579 |
| 37 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.72378500 |
| 38 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.72316675 |
| 39 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.71737823 |
| 40 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.69158329 |
| 41 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.66721349 |
| 42 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.65950919 |
| 43 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.65291975 |
| 44 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.55957672 |
| 45 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.55835144 |
| 46 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.52748533 |
| 47 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.51989016 |
| 48 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.48431601 |
| 49 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.48330012 |
| 50 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.47412062 |
| 51 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.46265605 |
| 52 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.45864631 |
| 53 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.42062962 |
| 54 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.41923251 |
| 55 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.41885248 |
| 56 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.40550083 |
| 57 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.39320962 |
| 58 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.39140129 |
| 59 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.39060325 |
| 60 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.35787491 |
| 61 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.25780694 |
| 62 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.25586936 |
| 63 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.25050830 |
| 64 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.23157356 |
| 65 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.21383649 |
| 66 | * AR_19668381_ChIP-Seq_PC3_Human | 1.21067991 |
| 67 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18089075 |
| 68 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.17348782 |
| 69 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.14390155 |
| 70 | * TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.14305688 |
| 71 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.12547330 |
| 72 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12206043 |
| 73 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.11222379 |
| 74 | VDR_22108803_ChIP-Seq_LS180_Human | 1.09656349 |
| 75 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.09412586 |
| 76 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.07230307 |
| 77 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.04658051 |
| 78 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.04330697 |
| 79 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.04179468 |
| 80 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.03223653 |
| 81 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.02923614 |
| 82 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01727545 |
| 83 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.01727545 |
| 84 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.01118732 |
| 85 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.00589299 |
| 86 | * ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.00583738 |
| 87 | P300_19829295_ChIP-Seq_ESCs_Human | 0.99117155 |
| 88 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.97832415 |
| 89 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.96482554 |
| 90 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.95946204 |
| 91 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.94897412 |
| 92 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.94585938 |
| 93 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.93754080 |
| 94 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.93732851 |
| 95 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.93384106 |
| 96 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.92872401 |
| 97 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.91809289 |
| 98 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.91533772 |
| 99 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91472068 |
| 100 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.89265903 |
| 101 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.89115014 |
| 102 | MYC_22102868_ChIP-Seq_BL_Human | 0.88815779 |
| 103 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.88486838 |
| 104 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.88240426 |
| 105 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.88014637 |
| 106 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.87669259 |
| 107 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.86591598 |
| 108 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.86063586 |
| 109 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.85966007 |
| 110 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.85854601 |
| 111 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.85540389 |
| 112 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85358904 |
| 113 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.85082022 |
| 114 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.85054440 |
| 115 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.84964873 |
| 116 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.84430574 |
| 117 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.84055861 |
| 118 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.83808049 |
| 119 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.82272210 |
| 120 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.82148012 |
| 121 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.82004776 |
| 122 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 0.81928129 |
| 123 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.81890892 |
| 124 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.81556942 |
| 125 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.81281134 |
| 126 | AR_25329375_ChIP-Seq_VCAP_Human | 0.80582051 |
| 127 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.79106646 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.29561404 |
| 2 | MP0000778_abnormal_nervous_system | 3.47751619 |
| 3 | MP0004270_analgesia | 3.44987758 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.39803210 |
| 5 | MP0005423_abnormal_somatic_nervous | 3.32507925 |
| 6 | MP0002063_abnormal_learning/memory/cond | 2.83710171 |
| 7 | MP0003880_abnormal_central_pattern | 2.83027589 |
| 8 | MP0002184_abnormal_innervation | 2.56430034 |
| 9 | MP0000537_abnormal_urethra_morphology | 2.44912290 |
| 10 | MP0009046_muscle_twitch | 2.39112088 |
| 11 | MP0002734_abnormal_mechanical_nocicepti | 2.36567176 |
| 12 | MP0009745_abnormal_behavioral_response | 2.24455732 |
| 13 | MP0004885_abnormal_endolymph | 2.17344406 |
| 14 | MP0000955_abnormal_spinal_cord | 2.11523734 |
| 15 | MP0005187_abnormal_penis_morphology | 2.08091534 |
| 16 | MP0000569_abnormal_digit_pigmentation | 2.08029449 |
| 17 | MP0004858_abnormal_nervous_system | 2.07998017 |
| 18 | MP0002572_abnormal_emotion/affect_behav | 2.07849063 |
| 19 | MP0004811_abnormal_neuron_physiology | 2.06187873 |
| 20 | MP0002064_seizures | 2.05339271 |
| 21 | MP0002822_catalepsy | 2.00204647 |
| 22 | MP0008569_lethality_at_weaning | 1.96793263 |
| 23 | MP0003123_paternal_imprinting | 1.92770706 |
| 24 | MP0009780_abnormal_chondrocyte_physiolo | 1.86227060 |
| 25 | MP0002733_abnormal_thermal_nociception | 1.86028996 |
| 26 | MP0002557_abnormal_social/conspecific_i | 1.86017242 |
| 27 | MP0001968_abnormal_touch/_nociception | 1.83671238 |
| 28 | MP0001486_abnormal_startle_reflex | 1.80168460 |
| 29 | MP0001440_abnormal_grooming_behavior | 1.78518068 |
| 30 | MP0002067_abnormal_sensory_capabilities | 1.76105877 |
| 31 | MP0000566_synostosis | 1.75008171 |
| 32 | MP0002735_abnormal_chemical_nociception | 1.74565446 |
| 33 | MP0002152_abnormal_brain_morphology | 1.72706431 |
| 34 | MP0006276_abnormal_autonomic_nervous | 1.71471199 |
| 35 | MP0003787_abnormal_imprinting | 1.67237863 |
| 36 | MP0003861_abnormal_nervous_system | 1.67224888 |
| 37 | MP0002882_abnormal_neuron_morphology | 1.66690686 |
| 38 | MP0008877_abnormal_DNA_methylation | 1.65213342 |
| 39 | MP0002653_abnormal_ependyma_morphology | 1.64882816 |
| 40 | MP0001188_hyperpigmentation | 1.64217073 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.63401218 |
| 42 | MP0004133_heterotaxia | 1.62560369 |
| 43 | MP0004924_abnormal_behavior | 1.60686939 |
| 44 | MP0005386_behavior/neurological_phenoty | 1.60686939 |
| 45 | MP0003329_amyloid_beta_deposits | 1.60099016 |
| 46 | MP0001529_abnormal_vocalization | 1.59075579 |
| 47 | MP0002272_abnormal_nervous_system | 1.56913447 |
| 48 | MP0005394_taste/olfaction_phenotype | 1.55355862 |
| 49 | MP0005499_abnormal_olfactory_system | 1.55355862 |
| 50 | MP0002638_abnormal_pupillary_reflex | 1.51001001 |
| 51 | MP0005377_hearing/vestibular/ear_phenot | 1.50059384 |
| 52 | MP0003878_abnormal_ear_physiology | 1.50059384 |
| 53 | MP0000751_myopathy | 1.44879014 |
| 54 | MP0003119_abnormal_digestive_system | 1.44170325 |
| 55 | MP0000049_abnormal_middle_ear | 1.44123602 |
| 56 | MP0001970_abnormal_pain_threshold | 1.42376862 |
| 57 | MP0002066_abnormal_motor_capabilities/c | 1.38794596 |
| 58 | MP0008789_abnormal_olfactory_epithelium | 1.36458076 |
| 59 | MP0003137_abnormal_impulse_conducting | 1.35584984 |
| 60 | MP0005248_abnormal_Harderian_gland | 1.32430110 |
| 61 | MP0004145_abnormal_muscle_electrophysio | 1.28530037 |
| 62 | MP0000631_abnormal_neuroendocrine_gland | 1.28419968 |
| 63 | MP0004233_abnormal_muscle_weight | 1.27854092 |
| 64 | MP0002736_abnormal_nociception_after | 1.27701461 |
| 65 | MP0001984_abnormal_olfaction | 1.26132687 |
| 66 | MP0003136_yellow_coat_color | 1.22012571 |
| 67 | MP0004742_abnormal_vestibular_system | 1.21852523 |
| 68 | MP0008961_abnormal_basal_metabolism | 1.16398357 |
| 69 | MP0002249_abnormal_larynx_morphology | 1.13837632 |
| 70 | MP0000026_abnormal_inner_ear | 1.12706387 |
| 71 | MP0001293_anophthalmia | 1.10314783 |
| 72 | MP0001485_abnormal_pinna_reflex | 1.07362017 |
| 73 | MP0002234_abnormal_pharynx_morphology | 1.05074394 |
| 74 | MP0003385_abnormal_body_wall | 1.01848897 |
| 75 | MP0002752_abnormal_somatic_nervous | 1.00624095 |
| 76 | MP0003283_abnormal_digestive_organ | 0.98846912 |
| 77 | MP0003937_abnormal_limbs/digits/tail_de | 0.98497650 |
| 78 | MP0003890_abnormal_embryonic-extraembry | 0.98244434 |
| 79 | MP0002081_perinatal_lethality | 0.97720164 |
| 80 | MP0001905_abnormal_dopamine_level | 0.95898113 |
| 81 | MP0002837_dystrophic_cardiac_calcinosis | 0.95678623 |
| 82 | MP0001963_abnormal_hearing_physiology | 0.95673403 |
| 83 | MP0001502_abnormal_circadian_rhythm | 0.95471731 |
| 84 | MP0004085_abnormal_heartbeat | 0.95403992 |
| 85 | MP0004215_abnormal_myocardial_fiber | 0.94881263 |
| 86 | MP0003122_maternal_imprinting | 0.94231730 |
| 87 | MP0005551_abnormal_eye_electrophysiolog | 0.92231062 |
| 88 | MP0001348_abnormal_lacrimal_gland | 0.92200405 |
| 89 | MP0003632_abnormal_nervous_system | 0.90511470 |
| 90 | MP0002069_abnormal_eating/drinking_beha | 0.88468058 |
| 91 | MP0001501_abnormal_sleep_pattern | 0.88016198 |
| 92 | MP0006292_abnormal_olfactory_placode | 0.87972750 |
| 93 | MP0002938_white_spotting | 0.87346025 |
| 94 | MP0005645_abnormal_hypothalamus_physiol | 0.87080593 |
| 95 | MP0010030_abnormal_orbit_morphology | 0.85697863 |
| 96 | MP0009053_abnormal_anal_canal | 0.85575461 |
| 97 | MP0004142_abnormal_muscle_tone | 0.84565819 |
| 98 | MP0002751_abnormal_autonomic_nervous | 0.83918539 |
| 99 | MP0001286_abnormal_eye_development | 0.83758745 |
| 100 | MP0003121_genomic_imprinting | 0.83280609 |
| 101 | MP0003705_abnormal_hypodermis_morpholog | 0.81865341 |
| 102 | MP0003631_nervous_system_phenotype | 0.81488350 |
| 103 | MP0010769_abnormal_survival | 0.81476435 |
| 104 | MP0003938_abnormal_ear_development | 0.81416099 |
| 105 | MP0003879_abnormal_hair_cell | 0.80972654 |
| 106 | MP0002089_abnormal_postnatal_growth/wei | 0.80805822 |
| 107 | MP0003634_abnormal_glial_cell | 0.80795618 |
| 108 | MP0000534_abnormal_ureter_morphology | 0.80358477 |
| 109 | MP0002102_abnormal_ear_morphology | 0.80330440 |
| 110 | MP0003633_abnormal_nervous_system | 0.79893557 |
| 111 | MP0001849_ear_inflammation | 0.79824117 |
| 112 | MP0002082_postnatal_lethality | 0.79264236 |
| 113 | MP0010770_preweaning_lethality | 0.79264236 |
| 114 | MP0002233_abnormal_nose_morphology | 0.78470943 |
| 115 | MP0003646_muscle_fatigue | 0.78050609 |
| 116 | MP0004130_abnormal_muscle_cell | 0.77860856 |
| 117 | MP0005195_abnormal_posterior_eye | 0.77423321 |
| 118 | MP0009379_abnormal_foot_pigmentation | 0.76835583 |
| 119 | MP0010768_mortality/aging | 0.76711076 |
| 120 | MP0006072_abnormal_retinal_apoptosis | 0.76506786 |
| 121 | MP0005076_abnormal_cell_differentiation | 0.75729191 |
| 122 | MP0003755_abnormal_palate_morphology | 0.75097465 |
| 123 | MP0003567_abnormal_fetal_cardiomyocyte | 0.73934927 |
| 124 | MP0001299_abnormal_eye_distance/ | 0.73584089 |
| 125 | MP0000579_abnormal_nail_morphology | 0.73528268 |
| 126 | MP0003942_abnormal_urinary_system | 0.72157332 |
| 127 | MP0003315_abnormal_perineum_morphology | 0.70431041 |
| 128 | MP0001943_abnormal_respiration | 0.68642988 |
| 129 | MP0003115_abnormal_respiratory_system | 0.67943035 |
| 130 | MP0002116_abnormal_craniofacial_bone | 0.67672523 |
| 131 | MP0003935_abnormal_craniofacial_develop | 0.64903071 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 3.93944852 |
| 2 | Amyotrophic lateral sclerosis (HP:0007354) | 3.85572311 |
| 3 | Progressive cerebellar ataxia (HP:0002073) | 3.61102168 |
| 4 | Visual hallucinations (HP:0002367) | 3.39715968 |
| 5 | Cortical dysplasia (HP:0002539) | 3.38028044 |
| 6 | Abnormality of the lower motor neuron (HP:0002366) | 3.36812424 |
| 7 | Action tremor (HP:0002345) | 3.35105634 |
| 8 | Hyperacusis (HP:0010780) | 3.32595762 |
| 9 | Supranuclear gaze palsy (HP:0000605) | 3.29918685 |
| 10 | Focal seizures (HP:0007359) | 3.22543155 |
| 11 | Abnormality of the corticospinal tract (HP:0002492) | 3.10173027 |
| 12 | Insomnia (HP:0100785) | 3.00945396 |
| 13 | Genetic anticipation (HP:0003743) | 3.00289044 |
| 14 | Elfin facies (HP:0004428) | 2.94090223 |
| 15 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.92015150 |
| 16 | Short 4th metacarpal (HP:0010044) | 2.92015150 |
| 17 | Pachygyria (HP:0001302) | 2.89157024 |
| 18 | Broad-based gait (HP:0002136) | 2.88655201 |
| 19 | Mutism (HP:0002300) | 2.88124305 |
| 20 | Abnormality of the labia minora (HP:0012880) | 2.87679837 |
| 21 | Ankle clonus (HP:0011448) | 2.87425127 |
| 22 | Drooling (HP:0002307) | 2.84745749 |
| 23 | Excessive salivation (HP:0003781) | 2.84745749 |
| 24 | Termporal pattern (HP:0011008) | 2.80080675 |
| 25 | Insidious onset (HP:0003587) | 2.80080675 |
| 26 | Hepatoblastoma (HP:0002884) | 2.78921178 |
| 27 | Hemiparesis (HP:0001269) | 2.78170415 |
| 28 | Septo-optic dysplasia (HP:0100842) | 2.65401408 |
| 29 | Megalencephaly (HP:0001355) | 2.59920445 |
| 30 | Urinary urgency (HP:0000012) | 2.57895049 |
| 31 | Pointed chin (HP:0000307) | 2.57827736 |
| 32 | Overriding aorta (HP:0002623) | 2.57142831 |
| 33 | Renovascular hypertension (HP:0100817) | 2.55441046 |
| 34 | Poor eye contact (HP:0000817) | 2.55167945 |
| 35 | Limb dystonia (HP:0002451) | 2.52608081 |
| 36 | Focal motor seizures (HP:0011153) | 2.50679966 |
| 37 | Polyphagia (HP:0002591) | 2.50431936 |
| 38 | Sacral dimple (HP:0000960) | 2.47792885 |
| 39 | Epileptic encephalopathy (HP:0200134) | 2.46993220 |
| 40 | Renal duplication (HP:0000075) | 2.46838240 |
| 41 | Abnormality of the 4th metacarpal (HP:0010012) | 2.46010780 |
| 42 | Abnormal social behavior (HP:0012433) | 2.43496657 |
| 43 | Impaired social interactions (HP:0000735) | 2.43496657 |
| 44 | Dysmetric saccades (HP:0000641) | 2.41885176 |
| 45 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.41842325 |
| 46 | Hypoplasia of the brainstem (HP:0002365) | 2.41842325 |
| 47 | Shawl scrotum (HP:0000049) | 2.41075298 |
| 48 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.38042833 |
| 49 | Rib fusion (HP:0000902) | 2.34938154 |
| 50 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.34500402 |
| 51 | Optic nerve hypoplasia (HP:0000609) | 2.33239068 |
| 52 | Agitation (HP:0000713) | 2.33191067 |
| 53 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.32033117 |
| 54 | Truncal ataxia (HP:0002078) | 2.30763462 |
| 55 | Apathy (HP:0000741) | 2.30272816 |
| 56 | Inappropriate behavior (HP:0000719) | 2.25120440 |
| 57 | Spastic gait (HP:0002064) | 2.24590943 |
| 58 | High anterior hairline (HP:0009890) | 2.24476917 |
| 59 | Abnormality of the aortic arch (HP:0012303) | 2.24237006 |
| 60 | Lissencephaly (HP:0001339) | 2.22330821 |
| 61 | Dysdiadochokinesis (HP:0002075) | 2.22129181 |
| 62 | Macroorchidism (HP:0000053) | 2.21450960 |
| 63 | Impaired smooth pursuit (HP:0007772) | 2.21325027 |
| 64 | Generalized tonic-clonic seizures (HP:0002069) | 2.20094982 |
| 65 | Shoulder girdle muscle weakness (HP:0003547) | 2.18914400 |
| 66 | Lymphangioma (HP:0100764) | 2.18743554 |
| 67 | Depression (HP:0000716) | 2.18191867 |
| 68 | Trigonocephaly (HP:0000243) | 2.17431588 |
| 69 | Cutaneous finger syndactyly (HP:0010554) | 2.17301633 |
| 70 | Sleep apnea (HP:0010535) | 2.16658702 |
| 71 | Abnormality of the astrocytes (HP:0100707) | 2.15406669 |
| 72 | Astrocytoma (HP:0009592) | 2.15406669 |
| 73 | Shallow orbits (HP:0000586) | 2.15262655 |
| 74 | Lower limb asymmetry (HP:0100559) | 2.13206150 |
| 75 | Gait imbalance (HP:0002141) | 2.13104815 |
| 76 | Aqueductal stenosis (HP:0002410) | 2.12822172 |
| 77 | Gaze-evoked nystagmus (HP:0000640) | 2.12127818 |
| 78 | Neoplasm of the heart (HP:0100544) | 2.11663519 |
| 79 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.09565786 |
| 80 | Impulsivity (HP:0100710) | 2.09539506 |
| 81 | Fetal akinesia sequence (HP:0001989) | 2.08363067 |
| 82 | Morphological abnormality of the middle ear (HP:0008609) | 2.08036438 |
| 83 | Hypsarrhythmia (HP:0002521) | 2.07423472 |
| 84 | Diminished motivation (HP:0000745) | 2.06844792 |
| 85 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.06726536 |
| 86 | Amblyopia (HP:0000646) | 2.06408442 |
| 87 | Anophthalmia (HP:0000528) | 2.06057819 |
| 88 | Intention tremor (HP:0002080) | 2.04381910 |
| 89 | Protruding tongue (HP:0010808) | 2.03320613 |
| 90 | Obstructive sleep apnea (HP:0002870) | 2.03107625 |
| 91 | Cutaneous syndactyly (HP:0012725) | 2.03003260 |
| 92 | EEG with generalized epileptiform discharges (HP:0011198) | 2.02289731 |
| 93 | Turricephaly (HP:0000262) | 2.02116952 |
| 94 | Oligodactyly (hands) (HP:0001180) | 2.01327639 |
| 95 | Diplopia (HP:0000651) | 2.00408063 |
| 96 | Abnormality of binocular vision (HP:0011514) | 2.00408063 |
| 97 | Germ cell neoplasia (HP:0100728) | 1.99828035 |
| 98 | Stereotypic behavior (HP:0000733) | 1.99779007 |
| 99 | Nephronophthisis (HP:0000090) | 1.99464227 |
| 100 | Heterotopia (HP:0002282) | 1.99104929 |
| 101 | Absent septum pellucidum (HP:0001331) | 1.98647269 |
| 102 | Abnormality of the diencephalon (HP:0010662) | 1.97189590 |
| 103 | Cerebral inclusion bodies (HP:0100314) | 1.96653008 |
| 104 | Hyperventilation (HP:0002883) | 1.96184648 |
| 105 | Hemiplegia (HP:0002301) | 1.95981014 |
| 106 | Akinesia (HP:0002304) | 1.95816649 |
| 107 | Dialeptic seizures (HP:0011146) | 1.95305535 |
| 108 | Epileptiform EEG discharges (HP:0011182) | 1.93120916 |
| 109 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.91874026 |
| 110 | Absence seizures (HP:0002121) | 1.91443213 |
| 111 | Hamartoma of the eye (HP:0010568) | 1.90791906 |
| 112 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.90719260 |
| 113 | Patellar aplasia (HP:0006443) | 1.89765650 |
| 114 | Atonic seizures (HP:0010819) | 1.89537849 |
| 115 | Flat cornea (HP:0007720) | 1.87861380 |
| 116 | Polymicrogyria (HP:0002126) | 1.87296102 |
| 117 | Scanning speech (HP:0002168) | 1.87146211 |
| 118 | Hypoplasia of the corpus callosum (HP:0002079) | 1.87079300 |
| 119 | Obsessive-compulsive behavior (HP:0000722) | 1.86792619 |
| 120 | Febrile seizures (HP:0002373) | 1.85920127 |
| 121 | Lower limb muscle weakness (HP:0007340) | 1.84359216 |
| 122 | Abnormal eating behavior (HP:0100738) | 1.83164762 |
| 123 | Sporadic (HP:0003745) | 1.82994112 |
| 124 | Abnormal number of incisors (HP:0011064) | 1.82641594 |
| 125 | Restlessness (HP:0000711) | 1.80900130 |
| 126 | Renal dysplasia (HP:0000110) | 1.80375088 |
| 127 | Oligodactyly (HP:0012165) | 1.80238047 |
| 128 | Abnormality of the pubic bones (HP:0003172) | 1.80156409 |
| 129 | Retinal dysplasia (HP:0007973) | 1.78564100 |
| 130 | Congenital stationary night blindness (HP:0007642) | 1.78022107 |
| 131 | Torticollis (HP:0000473) | 1.77483738 |
| 132 | Subacute progressive viral hepatitis (HP:0006572) | 1.77380204 |
| 133 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.77131347 |
| 134 | Partial agenesis of the corpus callosum (HP:0001338) | 1.76167219 |
| 135 | Pheochromocytoma (HP:0002666) | 1.75591316 |
| 136 | Dysmetria (HP:0001310) | 1.75320522 |
| 137 | Megalocornea (HP:0000485) | 1.74777176 |
| 138 | Specific learning disability (HP:0001328) | 1.73601613 |
| 139 | Bilateral microphthalmos (HP:0007633) | 1.72782164 |
| 140 | Failure to thrive in infancy (HP:0001531) | 1.71802507 |
| 141 | Myotonia (HP:0002486) | 1.71340466 |
| 142 | Vaginal atresia (HP:0000148) | 1.70879747 |
| 143 | Exotropia (HP:0000577) | 1.70682411 |
| 144 | Anencephaly (HP:0002323) | 1.69880091 |
| 145 | Spina bifida occulta (HP:0003298) | 1.68924688 |
| 146 | Abnormality of the septum pellucidum (HP:0007375) | 1.68861127 |
| 147 | Growth hormone deficiency (HP:0000824) | 1.66727178 |
| 148 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.66662655 |
| 149 | Vitreoretinal degeneration (HP:0000655) | 1.65282385 |
| 150 | Genital tract atresia (HP:0001827) | 1.63496639 |
| 151 | Myelomeningocele (HP:0002475) | 1.63423527 |
| 152 | Optic nerve coloboma (HP:0000588) | 1.62656503 |
| 153 | Esotropia (HP:0000565) | 1.62180165 |
| 154 | Maternal diabetes (HP:0009800) | 1.61720899 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 7.23115580 |
| 2 | CASK | 4.76979573 |
| 3 | MAP3K9 | 2.98521911 |
| 4 | SIK2 | 2.41564976 |
| 5 | NTRK2 | 2.35523445 |
| 6 | EPHB2 | 2.23042063 |
| 7 | MAP3K4 | 2.22548358 |
| 8 | PHKG2 | 2.20902459 |
| 9 | PHKG1 | 2.20902459 |
| 10 | MINK1 | 2.18777875 |
| 11 | DYRK2 | 2.12921153 |
| 12 | KSR1 | 2.10632885 |
| 13 | PAK6 | 1.97606418 |
| 14 | TRIB3 | 1.97301282 |
| 15 | MAPK13 | 1.97049071 |
| 16 | ERBB3 | 1.88377132 |
| 17 | TYRO3 | 1.87913670 |
| 18 | MAP3K10 | 1.79772599 |
| 19 | DAPK2 | 1.72975020 |
| 20 | ICK | 1.70281239 |
| 21 | RIPK1 | 1.69352952 |
| 22 | NTRK3 | 1.65834490 |
| 23 | CAMK1D | 1.44485695 |
| 24 | CAMKK1 | 1.42740024 |
| 25 | LATS2 | 1.39223523 |
| 26 | UHMK1 | 1.36942414 |
| 27 | PKN2 | 1.33409327 |
| 28 | MAP2K7 | 1.31295798 |
| 29 | CSNK1G2 | 1.24454973 |
| 30 | FGFR2 | 1.23631235 |
| 31 | CDK5 | 1.19906195 |
| 32 | TAOK1 | 1.16656534 |
| 33 | EEF2K | 1.16215379 |
| 34 | STK11 | 1.13562827 |
| 35 | EPHA4 | 1.11985278 |
| 36 | MARK2 | 1.08977845 |
| 37 | MAP2K4 | 1.08823189 |
| 38 | ALK | 0.99207985 |
| 39 | CSNK1A1L | 0.97990252 |
| 40 | CSNK1G3 | 0.96988544 |
| 41 | CAMK1G | 0.96333088 |
| 42 | PNCK | 0.93473411 |
| 43 | PRKD3 | 0.92322423 |
| 44 | RET | 0.91992926 |
| 45 | CDK15 | 0.91097188 |
| 46 | MKNK2 | 0.90906812 |
| 47 | CDK18 | 0.90091183 |
| 48 | DYRK1A | 0.89619706 |
| 49 | LIMK1 | 0.89525015 |
| 50 | INSRR | 0.89404223 |
| 51 | PDGFRA | 0.89339185 |
| 52 | KSR2 | 0.87407517 |
| 53 | PKN1 | 0.84067906 |
| 54 | PAK3 | 0.83676074 |
| 55 | CDK14 | 0.83281957 |
| 56 | PTK6 | 0.82933130 |
| 57 | LMTK2 | 0.81594841 |
| 58 | CDK11A | 0.79983728 |
| 59 | PRKCZ | 0.79802298 |
| 60 | PRPF4B | 0.77972806 |
| 61 | PRKCG | 0.77108935 |
| 62 | ERBB2 | 0.77020640 |
| 63 | PINK1 | 0.76954041 |
| 64 | DYRK1B | 0.74331907 |
| 65 | CAMK1 | 0.73257237 |
| 66 | CDC42BPA | 0.72636220 |
| 67 | WNK4 | 0.71957355 |
| 68 | DYRK3 | 0.71822981 |
| 69 | STK38 | 0.67692891 |
| 70 | RPS6KA2 | 0.66087606 |
| 71 | WNK3 | 0.65986208 |
| 72 | CDK19 | 0.65981595 |
| 73 | SGK223 | 0.65562279 |
| 74 | SGK494 | 0.65562279 |
| 75 | BRD4 | 0.64136910 |
| 76 | CSNK1G1 | 0.63533329 |
| 77 | PRKCH | 0.61855412 |
| 78 | CAMK4 | 0.60566151 |
| 79 | PRKAA1 | 0.58375043 |
| 80 | NTRK1 | 0.57681269 |
| 81 | NEK2 | 0.57554569 |
| 82 | SGK3 | 0.56769621 |
| 83 | MAPK15 | 0.55952921 |
| 84 | FYN | 0.55703850 |
| 85 | DAPK1 | 0.55002653 |
| 86 | MAPK9 | 0.54614558 |
| 87 | TNIK | 0.54544003 |
| 88 | MAPK12 | 0.53934542 |
| 89 | MKNK1 | 0.48344515 |
| 90 | CAMK2A | 0.48021393 |
| 91 | CDK3 | 0.47872654 |
| 92 | ILK | 0.45896093 |
| 93 | CSNK1D | 0.44279328 |
| 94 | SCYL2 | 0.44017852 |
| 95 | MAPK8 | 0.43832529 |
| 96 | PRKD1 | 0.43272349 |
| 97 | WNK1 | 0.42350193 |
| 98 | BMPR1B | 0.42288878 |
| 99 | MAP3K6 | 0.42203507 |
| 100 | MTOR | 0.41979586 |
| 101 | NEK1 | 0.41215684 |
| 102 | SGK2 | 0.40918859 |
| 103 | DMPK | 0.40735939 |
| 104 | PLK4 | 0.40572087 |
| 105 | RPS6KA3 | 0.40469397 |
| 106 | STK38L | 0.40383139 |
| 107 | CDC7 | 0.39513816 |
| 108 | RPS6KA1 | 0.38619041 |
| 109 | PRKG1 | 0.36661238 |
| 110 | ROCK1 | 0.36580250 |
| 111 | CAMKK2 | 0.36523433 |
| 112 | SGK1 | 0.36497555 |
| 113 | OXSR1 | 0.35868778 |
| 114 | CSNK1E | 0.35106592 |
| 115 | DDR2 | 0.34903138 |
| 116 | PRKDC | 0.34033449 |
| 117 | FGFR1 | 0.33998247 |
| 118 | BCR | 0.33463761 |
| 119 | GSK3B | 0.33242275 |
| 120 | ROCK2 | 0.32794789 |
| 121 | PLK2 | 0.32368956 |
| 122 | MAPK10 | 0.30876536 |
| 123 | MAP2K2 | 0.30577063 |
| 124 | AKT1 | 0.30483615 |
| 125 | CSNK1A1 | 0.30418238 |
| 126 | CDK1 | 0.29841029 |
| 127 | GRK1 | 0.29780744 |
| 128 | CDK2 | 0.29779341 |
| 129 | OBSCN | 0.29696891 |
| 130 | FES | 0.29652398 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.69969365 |
| 2 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.26328854 |
| 3 | Axon guidance_Homo sapiens_hsa04360 | 2.20771052 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.15486462 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.05801395 |
| 6 | Long-term potentiation_Homo sapiens_hsa04720 | 2.04792755 |
| 7 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.00778670 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.95054186 |
| 9 | Phototransduction_Homo sapiens_hsa04744 | 1.90478636 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.89853100 |
| 11 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.88224866 |
| 12 | Morphine addiction_Homo sapiens_hsa05032 | 1.82422148 |
| 13 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.72961118 |
| 14 | Endometrial cancer_Homo sapiens_hsa05213 | 1.71408006 |
| 15 | Olfactory transduction_Homo sapiens_hsa04740 | 1.69634166 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.67909646 |
| 17 | Gap junction_Homo sapiens_hsa04540 | 1.64489580 |
| 18 | Long-term depression_Homo sapiens_hsa04730 | 1.63968233 |
| 19 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.58466923 |
| 20 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.53268607 |
| 21 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.48978480 |
| 22 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.48104869 |
| 23 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.47514519 |
| 24 | Colorectal cancer_Homo sapiens_hsa05210 | 1.47344647 |
| 25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.41876979 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.39453821 |
| 27 | Glioma_Homo sapiens_hsa05214 | 1.36294462 |
| 28 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.34770160 |
| 29 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.32715828 |
| 30 | Salivary secretion_Homo sapiens_hsa04970 | 1.32273105 |
| 31 | Taste transduction_Homo sapiens_hsa04742 | 1.31959366 |
| 32 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.28656298 |
| 33 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.27687313 |
| 34 | Insulin secretion_Homo sapiens_hsa04911 | 1.27395551 |
| 35 | Cocaine addiction_Homo sapiens_hsa05030 | 1.25696895 |
| 36 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.25112041 |
| 37 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.24359987 |
| 38 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.23357241 |
| 39 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.19705895 |
| 40 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.17805852 |
| 41 | Renin secretion_Homo sapiens_hsa04924 | 1.16807312 |
| 42 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.15938420 |
| 43 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.15810778 |
| 44 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.14024346 |
| 45 | Melanogenesis_Homo sapiens_hsa04916 | 1.12792526 |
| 46 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.07559879 |
| 47 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.07250115 |
| 48 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.05857695 |
| 49 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.05540464 |
| 50 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.03709444 |
| 51 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.00207167 |
| 52 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.97834658 |
| 53 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.97232954 |
| 54 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.95105368 |
| 55 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.95005655 |
| 56 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.94544909 |
| 57 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.94315035 |
| 58 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.93993375 |
| 59 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.93730029 |
| 60 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.93695705 |
| 61 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.93095020 |
| 62 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.91957571 |
| 63 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.91282340 |
| 64 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.90955103 |
| 65 | Viral myocarditis_Homo sapiens_hsa05416 | 0.90632569 |
| 66 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.90274773 |
| 67 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.88820443 |
| 68 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.88551788 |
| 69 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.88463827 |
| 70 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.88088097 |
| 71 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.86912556 |
| 72 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.86621862 |
| 73 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.85112126 |
| 74 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.84350281 |
| 75 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.81263754 |
| 76 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.80621406 |
| 77 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.80538949 |
| 78 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.78668908 |
| 79 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.78249208 |
| 80 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.77765851 |
| 81 | Alcoholism_Homo sapiens_hsa05034 | 0.76481924 |
| 82 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.76422844 |
| 83 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.75168938 |
| 84 | Lysine degradation_Homo sapiens_hsa00310 | 0.71583648 |
| 85 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.70306323 |
| 86 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.66373175 |
| 87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.63668100 |
| 88 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.63602260 |
| 89 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.62903324 |
| 90 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.62622393 |
| 91 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.62617201 |
| 92 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.62403597 |
| 93 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.60230743 |
| 94 | Tight junction_Homo sapiens_hsa04530 | 0.60162366 |
| 95 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.59802720 |
| 96 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.59642832 |
| 97 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.59277110 |
| 98 | Parkinsons disease_Homo sapiens_hsa05012 | 0.57834030 |
| 99 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.57761088 |
| 100 | Alzheimers disease_Homo sapiens_hsa05010 | 0.57630919 |
| 101 | Bile secretion_Homo sapiens_hsa04976 | 0.56617213 |
| 102 | Insulin resistance_Homo sapiens_hsa04931 | 0.56427396 |
| 103 | Endocytosis_Homo sapiens_hsa04144 | 0.55520056 |
| 104 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.55055636 |
| 105 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.54497518 |
| 106 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.54123307 |
| 107 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.54085417 |
| 108 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.52260298 |
| 109 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.51924764 |
| 110 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.51904834 |
| 111 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.50525577 |
| 112 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.49778169 |
| 113 | Huntingtons disease_Homo sapiens_hsa05016 | 0.47541787 |
| 114 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.47485744 |
| 115 | Adherens junction_Homo sapiens_hsa04520 | 0.47404815 |
| 116 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.46672094 |
| 117 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.45714242 |
| 118 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.43296190 |
| 119 | Basal transcription factors_Homo sapiens_hsa03022 | 0.43277164 |
| 120 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.35945448 |

