

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of skeletal muscle contraction (GO:0014819) | 9.90298891 |
| 2 | actin-mediated cell contraction (GO:0070252) | 9.21453019 |
| 3 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 9.10311621 |
| 4 | skeletal muscle contraction (GO:0003009) | 8.38355353 |
| 5 | plasma membrane repair (GO:0001778) | 7.99880758 |
| 6 | sarcomere organization (GO:0045214) | 7.82927566 |
| 7 | skeletal muscle adaptation (GO:0043501) | 7.30761798 |
| 8 | regulation of cardioblast differentiation (GO:0051890) | 7.24916147 |
| 9 | actin filament-based movement (GO:0030048) | 6.96843313 |
| 10 | myofibril assembly (GO:0030239) | 6.77528855 |
| 11 | cytidine deamination (GO:0009972) | 6.61747344 |
| 12 | cytidine metabolic process (GO:0046087) | 6.61747344 |
| 13 | cytidine catabolic process (GO:0006216) | 6.61747344 |
| 14 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 6.47820145 |
| 15 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.43166403 |
| 16 | striated muscle contraction (GO:0006941) | 6.30382389 |
| 17 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 6.29962454 |
| 18 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 6.29624231 |
| 19 | ventricular cardiac muscle cell development (GO:0055015) | 6.07504004 |
| 20 | potassium ion export (GO:0071435) | 5.76736535 |
| 21 | atrioventricular valve morphogenesis (GO:0003181) | 5.71749037 |
| 22 | regulation of relaxation of muscle (GO:1901077) | 5.59939614 |
| 23 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 5.55200141 |
| 24 | negative regulation of cardiac muscle hypertrophy (GO:0010614) | 5.54143341 |
| 25 | cardiac chamber formation (GO:0003207) | 5.48355125 |
| 26 | skeletal muscle fiber development (GO:0048741) | 5.47104212 |
| 27 | cardiac myofibril assembly (GO:0055003) | 5.42346969 |
| 28 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.36876681 |
| 29 | creatine metabolic process (GO:0006600) | 5.26653924 |
| 30 | carnitine shuttle (GO:0006853) | 5.25001087 |
| 31 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 5.21114172 |
| 32 | actomyosin structure organization (GO:0031032) | 5.20919694 |
| 33 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.15692736 |
| 34 | regulation of cell proliferation involved in heart morphogenesis (GO:2000136) | 5.13921949 |
| 35 | cardiac muscle contraction (GO:0060048) | 5.06536235 |
| 36 | keratinization (GO:0031424) | 5.02736913 |
| 37 | regulation of the force of heart contraction (GO:0002026) | 5.01419029 |
| 38 | cardiac ventricle formation (GO:0003211) | 5.00969080 |
| 39 | muscle contraction (GO:0006936) | 4.99853024 |
| 40 | striated muscle atrophy (GO:0014891) | 4.98867475 |
| 41 | regulation of cell communication by electrical coupling (GO:0010649) | 4.94248495 |
| 42 | skeletal muscle tissue regeneration (GO:0043403) | 4.91163118 |
| 43 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.90475118 |
| 44 | endocardial cushion development (GO:0003197) | 4.88236579 |
| 45 | tricarboxylic acid cycle (GO:0006099) | 4.84030910 |
| 46 | response to muscle activity (GO:0014850) | 4.81613593 |
| 47 | cardiac muscle cell proliferation (GO:0060038) | 4.80589675 |
| 48 | atrial septum morphogenesis (GO:0060413) | 4.77428412 |
| 49 | striated muscle adaptation (GO:0014888) | 4.74797101 |
| 50 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 4.72273942 |
| 51 | regulation of cardioblast proliferation (GO:0003264) | 4.72273942 |
| 52 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.66772927 |
| 53 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.66368636 |
| 54 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 4.62966801 |
| 55 | positive regulation of cardiac muscle cell proliferation (GO:0060045) | 4.61506380 |
| 56 | myotube cell development (GO:0014904) | 4.60923321 |
| 57 | positive regulation of cardiac muscle tissue growth (GO:0055023) | 4.56342139 |
| 58 | cardiac muscle cell development (GO:0055013) | 4.53813865 |
| 59 | muscle system process (GO:0003012) | 4.51973538 |
| 60 | fatty acid transmembrane transport (GO:1902001) | 4.50817030 |
| 61 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.49518083 |
| 62 | response to inactivity (GO:0014854) | 4.43095458 |
| 63 | negative regulation of heart growth (GO:0061117) | 4.38804920 |
| 64 | negative regulation of cardiac muscle tissue growth (GO:0055022) | 4.38804920 |
| 65 | regulation of cardiac muscle contraction (GO:0055117) | 4.37096323 |
| 66 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.36102516 |
| 67 | regulation of cardiac muscle cell contraction (GO:0086004) | 4.34220297 |
| 68 | glycogen catabolic process (GO:0005980) | 4.32405397 |
| 69 | cardiac cell development (GO:0055006) | 4.26853303 |
| 70 | cGMP biosynthetic process (GO:0006182) | 4.26107515 |
| 71 | regulation of coenzyme metabolic process (GO:0051196) | 4.24982538 |
| 72 | regulation of cofactor metabolic process (GO:0051193) | 4.24982538 |
| 73 | muscle atrophy (GO:0014889) | 4.24910503 |
| 74 | muscle fiber development (GO:0048747) | 4.19770967 |
| 75 | striated muscle cell proliferation (GO:0014855) | 4.11558115 |
| 76 | cell migration involved in heart development (GO:0060973) | 4.09794659 |
| 77 | cell communication involved in cardiac conduction (GO:0086065) | 4.05087936 |
| 78 | glucan catabolic process (GO:0009251) | 4.02619464 |
| 79 | positive regulation of heart growth (GO:0060421) | 4.01538419 |
| 80 | cardiac muscle hypertrophy (GO:0003300) | 3.98185440 |
| 81 | regulation of actin filament-based movement (GO:1903115) | 3.97493730 |
| 82 | muscle adaptation (GO:0043500) | 3.97153271 |
| 83 | regulation of skeletal muscle cell differentiation (GO:2001014) | 3.96640472 |
| 84 | striated muscle hypertrophy (GO:0014897) | 3.95075542 |
| 85 | regulation of heart morphogenesis (GO:2000826) | 3.92483883 |
| 86 | glycogen biosynthetic process (GO:0005978) | 3.90065808 |
| 87 | glucan biosynthetic process (GO:0009250) | 3.90065808 |
| 88 | carnitine transmembrane transport (GO:1902603) | 3.88614899 |
| 89 | heart contraction (GO:0060047) | 3.88599881 |
| 90 | heart process (GO:0003015) | 3.88599881 |
| 91 | negative regulation of muscle hypertrophy (GO:0014741) | 3.87629838 |
| 92 | striated muscle cell development (GO:0055002) | 3.86771972 |
| 93 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 3.83579374 |
| 94 | regulation of cardiac muscle cell proliferation (GO:0060043) | 3.81706704 |
| 95 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.81569903 |
| 96 | regulation of striated muscle contraction (GO:0006942) | 3.80015774 |
| 97 | regulation of sarcomere organization (GO:0060297) | 3.79623407 |
| 98 | regulation of cardiac muscle tissue growth (GO:0055021) | 3.73366453 |
| 99 | cellular polysaccharide catabolic process (GO:0044247) | 3.73250597 |
| 100 | regulation of heart contraction (GO:0008016) | 3.70447436 |
| 101 | positive regulation of cardiac muscle tissue development (GO:0055025) | 3.70344641 |
| 102 | polysaccharide catabolic process (GO:0000272) | 3.69786093 |
| 103 | muscle tissue morphogenesis (GO:0060415) | 3.65019077 |
| 104 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.63969649 |
| 105 | positive regulation of action potential (GO:0045760) | 3.62736944 |
| 106 | desmosome organization (GO:0002934) | 3.62630333 |
| 107 | regulation of heart rate (GO:0002027) | 3.62456309 |
| 108 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.61604108 |
| 109 | regulation of heart growth (GO:0060420) | 3.59921482 |
| 110 | adult heart development (GO:0007512) | 3.59735726 |
| 111 | negative regulation of potassium ion transport (GO:0043267) | 3.58920134 |
| 112 | muscle cell fate commitment (GO:0042693) | 3.57822880 |
| 113 | muscle hypertrophy (GO:0014896) | 3.56017019 |
| 114 | detection of calcium ion (GO:0005513) | 3.52946074 |
| 115 | amino-acid betaine transport (GO:0015838) | 3.51983358 |
| 116 | carnitine transport (GO:0015879) | 3.51983358 |
| 117 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.51538614 |
| 118 | muscle cell proliferation (GO:0033002) | 3.47890741 |
| 119 | atrial cardiac muscle cell action potential (GO:0086014) | 3.47536086 |
| 120 | cardiac muscle cell action potential (GO:0086001) | 3.47403493 |
| 121 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.46849096 |
| 122 | cell communication by electrical coupling (GO:0010644) | 3.45700133 |
| 123 | regulation of sequestering of triglyceride (GO:0010889) | 3.45151117 |
| 124 | positive regulation of urine volume (GO:0035810) | 3.43263805 |
| 125 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.42379676 |
| 126 | regulation of sulfur metabolic process (GO:0042762) | 3.42078667 |
| 127 | pericardium development (GO:0060039) | 3.41494083 |
| 128 | regulation of ATP catabolic process (GO:1903289) | 3.41407088 |
| 129 | regulation of ATPase activity (GO:0043462) | 3.41407088 |
| 130 | muscle cell cellular homeostasis (GO:0046716) | 3.39565602 |
| 131 | positive regulation of myotube differentiation (GO:0010831) | 3.39328105 |
| 132 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.36723528 |
| 133 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.36411006 |
| 134 | cardiac muscle tissue development (GO:0048738) | 3.36095669 |
| 135 | negative regulation of protein localization to cell surface (GO:2000009) | 3.34427983 |
| 136 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.32515634 |
| 137 | muscle cell development (GO:0055001) | 3.29847954 |
| 138 | regulation of membrane repolarization (GO:0060306) | 3.29497226 |
| 139 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.28255626 |
| 140 | muscle hypertrophy in response to stress (GO:0003299) | 3.28255626 |
| 141 | cardiac muscle adaptation (GO:0014887) | 3.28255626 |
| 142 | hemidesmosome assembly (GO:0031581) | 3.28044918 |
| 143 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.27296680 |
| 144 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.27296680 |
| 145 | glycogen metabolic process (GO:0005977) | 3.26269498 |
| 146 | outflow tract septum morphogenesis (GO:0003148) | 3.25291245 |
| 147 | regulation of cardiac muscle tissue development (GO:0055024) | 3.24414438 |
| 148 | cardiac septum development (GO:0003279) | 3.24227407 |
| 149 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.20451649 |
| 150 | 2-oxoglutarate metabolic process (GO:0006103) | 3.19449725 |
| 151 | glucan metabolic process (GO:0044042) | 3.19122624 |
| 152 | cellular glucan metabolic process (GO:0006073) | 3.19122624 |
| 153 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.15913248 |
| 154 | NADH metabolic process (GO:0006734) | 3.15784121 |
| 155 | heart trabecula formation (GO:0060347) | 3.13874223 |
| 156 | actin-myosin filament sliding (GO:0033275) | 11.2805332 |
| 157 | muscle filament sliding (GO:0030049) | 11.2805332 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.66656480 |
| 2 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 5.48717783 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.19383201 |
| 4 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.42774836 |
| 5 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.33416421 |
| 6 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 3.04661638 |
| 7 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 2.99211017 |
| 8 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 2.99211017 |
| 9 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.80390979 |
| 10 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.80210919 |
| 11 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.78854452 |
| 12 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.77366963 |
| 13 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 2.67291320 |
| 14 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.64454067 |
| 15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.41184856 |
| 16 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.36630040 |
| 17 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.34804547 |
| 18 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.23146289 |
| 19 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.04668153 |
| 20 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.04354303 |
| 21 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.01613893 |
| 22 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.96284427 |
| 23 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.91632332 |
| 24 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.88129494 |
| 25 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.86165648 |
| 26 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.84163634 |
| 27 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.76102042 |
| 28 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.75613293 |
| 29 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.67813555 |
| 30 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.66200897 |
| 31 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.66107053 |
| 32 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.59958271 |
| 33 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.59763500 |
| 34 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.56950948 |
| 35 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.54184055 |
| 36 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.52332866 |
| 37 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.49865753 |
| 38 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.49492655 |
| 39 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.47875261 |
| 40 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.45813696 |
| 41 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.45134102 |
| 42 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.41225618 |
| 43 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.38152320 |
| 44 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.37344188 |
| 45 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.37179622 |
| 46 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.36313001 |
| 47 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.35558190 |
| 48 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.34816431 |
| 49 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.34562014 |
| 50 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.34423355 |
| 51 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.34352067 |
| 52 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.33289546 |
| 53 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.32952315 |
| 54 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.31424440 |
| 55 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.30609364 |
| 56 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.30213133 |
| 57 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.30022856 |
| 58 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.29747200 |
| 59 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.29740884 |
| 60 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.28920945 |
| 61 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.26504436 |
| 62 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.24692432 |
| 63 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.24117697 |
| 64 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.23978816 |
| 65 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.22546198 |
| 66 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.22367642 |
| 67 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.22367642 |
| 68 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.20986378 |
| 69 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.19815766 |
| 70 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.19005824 |
| 71 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.18844383 |
| 72 | ATF3_27146783_Chip-Seq_COLON_Human | 1.18746307 |
| 73 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.18431192 |
| 74 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.16841992 |
| 75 | KDM2B_26808549_Chip-Seq_K562_Human | 1.16780617 |
| 76 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.16376385 |
| 77 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.15691092 |
| 78 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.15653253 |
| 79 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.14597810 |
| 80 | P68_20966046_ChIP-Seq_HELA_Human | 1.12448637 |
| 81 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.12445050 |
| 82 | CJUN_26792858_Chip-Seq_BT549_Human | 1.11777243 |
| 83 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.11569140 |
| 84 | SA1_27219007_Chip-Seq_Bcells_Human | 1.11072585 |
| 85 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.10783149 |
| 86 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.10701049 |
| 87 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.09813885 |
| 88 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.09450301 |
| 89 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.06447488 |
| 90 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.04414807 |
| 91 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.04336972 |
| 92 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.04239848 |
| 93 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.04066776 |
| 94 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.04042208 |
| 95 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.03437176 |
| 96 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.03107935 |
| 97 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.01982030 |
| 98 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.01763833 |
| 99 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.01287069 |
| 100 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.00912177 |
| 101 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.00784599 |
| 102 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.00446615 |
| 103 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.00290258 |
| 104 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.99593207 |
| 105 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.99341908 |
| 106 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.98186734 |
| 107 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 0.97782059 |
| 108 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.97518715 |
| 109 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.97395258 |
| 110 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.96837644 |
| 111 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.96792022 |
| 112 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.96048632 |
| 113 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.95922684 |
| 114 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.95768844 |
| 115 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.95648092 |
| 116 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.95518328 |
| 117 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.95008142 |
| 118 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.94993481 |
| 119 | * RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.94489343 |
| 120 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.94228120 |
| 121 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.93998422 |
| 122 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.93431882 |
| 123 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.93044525 |
| 124 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.93032762 |
| 125 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.92878621 |
| 126 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.91385677 |
| 127 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.91277239 |
| 128 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.90893451 |
| 129 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.89811878 |
| 130 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.89294421 |
| 131 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.88683232 |
| 132 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.88619733 |
| 133 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88356391 |
| 134 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.88264348 |
| 135 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.88240900 |
| 136 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.87448638 |
| 137 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.87447451 |
| 138 | * SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.86811394 |
| 139 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.85830749 |
| 140 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.85473920 |
| 141 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.85218623 |
| 142 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.83972690 |
| 143 | GATA2_19941826_ChIP-Seq_K562_Human | 0.83959040 |
| 144 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.83448786 |
| 145 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.83184890 |
| 146 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.83148766 |
| 147 | RXR_22108803_ChIP-Seq_LS180_Human | 0.82474583 |
| 148 | GATA1_22025678_ChIP-Seq_K562_Human | 0.81972892 |
| 149 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.81458460 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 6.12381409 |
| 2 | MP0000751_myopathy | 5.69932711 |
| 3 | MP0000749_muscle_degeneration | 5.59925394 |
| 4 | MP0004145_abnormal_muscle_electrophysio | 5.13650345 |
| 5 | MP0002837_dystrophic_cardiac_calcinosis | 4.90360131 |
| 6 | MP0004036_abnormal_muscle_relaxation | 3.97848450 |
| 7 | MP0000747_muscle_weakness | 3.76120040 |
| 8 | MP0002106_abnormal_muscle_physiology | 3.62960166 |
| 9 | MP0004087_abnormal_muscle_fiber | 3.40685160 |
| 10 | MP0004084_abnormal_cardiac_muscle | 3.34823841 |
| 11 | MP0000759_abnormal_skeletal_muscle | 3.18594814 |
| 12 | MP0000750_abnormal_muscle_regeneration | 3.15857349 |
| 13 | MP0004130_abnormal_muscle_cell | 3.12157514 |
| 14 | MP0002269_muscular_atrophy | 3.00627127 |
| 15 | MP0005369_muscle_phenotype | 2.96298582 |
| 16 | MP0005620_abnormal_muscle_contractility | 2.93139643 |
| 17 | MP0005330_cardiomyopathy | 2.85127274 |
| 18 | MP0004215_abnormal_myocardial_fiber | 2.55557949 |
| 19 | MP0002972_abnormal_cardiac_muscle | 2.18163795 |
| 20 | MP0005410_abnormal_fertilization | 2.12896955 |
| 21 | MP0004233_abnormal_muscle_weight | 1.99940456 |
| 22 | MP0002332_abnormal_exercise_endurance | 1.94440628 |
| 23 | MP0005275_abnormal_skin_tensile | 1.93168375 |
| 24 | MP0004185_abnormal_adipocyte_glucose | 1.93099591 |
| 25 | MP0000733_abnormal_muscle_development | 1.88159449 |
| 26 | MP0004484_altered_response_of | 1.88128147 |
| 27 | MP0010630_abnormal_cardiac_muscle | 1.81050758 |
| 28 | MP0003279_aneurysm | 1.79160897 |
| 29 | MP0006036_abnormal_mitochondrial_physio | 1.77099686 |
| 30 | MP0008004_abnormal_stomach_pH | 1.76023788 |
| 31 | MP0002796_impaired_skin_barrier | 1.71678462 |
| 32 | MP0005385_cardiovascular_system_phenoty | 1.68526981 |
| 33 | MP0001544_abnormal_cardiovascular_syste | 1.68526981 |
| 34 | MP0005666_abnormal_adipose_tissue | 1.67659122 |
| 35 | MP0008775_abnormal_heart_ventricle | 1.55648242 |
| 36 | MP0001348_abnormal_lacrimal_gland | 1.54631306 |
| 37 | MP0003705_abnormal_hypodermis_morpholog | 1.52583545 |
| 38 | MP0003137_abnormal_impulse_conducting | 1.49776600 |
| 39 | MP0003221_abnormal_cardiomyocyte_apopto | 1.49144887 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.48160612 |
| 41 | MP0002108_abnormal_muscle_morphology | 1.45466039 |
| 42 | MP0003950_abnormal_plasma_membrane | 1.42821912 |
| 43 | MP0005503_abnormal_tendon_morphology | 1.41070582 |
| 44 | MP0004510_myositis | 1.40372380 |
| 45 | MP0002971_abnormal_brown_adipose | 1.35718119 |
| 46 | MP0005375_adipose_tissue_phenotype | 1.34809216 |
| 47 | MP0006138_congestive_heart_failure | 1.34143024 |
| 48 | MP0000767_abnormal_smooth_muscle | 1.33611715 |
| 49 | MP0009384_cardiac_valve_regurgitation | 1.26565753 |
| 50 | MP0000579_abnormal_nail_morphology | 1.25699143 |
| 51 | MP0005257_abnormal_intraocular_pressure | 1.24242855 |
| 52 | MP0005623_abnormal_meninges_morphology | 1.14040877 |
| 53 | MP0010030_abnormal_orbit_morphology | 1.11558738 |
| 54 | MP0003828_pulmonary_edema | 1.05810403 |
| 55 | MP0002127_abnormal_cardiovascular_syste | 0.96874129 |
| 56 | MP0010368_abnormal_lymphatic_system | 0.96153286 |
| 57 | MP0003011_delayed_dark_adaptation | 0.95280099 |
| 58 | MP0000003_abnormal_adipose_tissue | 0.94432635 |
| 59 | MP0000343_altered_response_to | 0.93775291 |
| 60 | MP0000762_abnormal_tongue_morphology | 0.92526813 |
| 61 | MP0004085_abnormal_heartbeat | 0.91963183 |
| 62 | MP0005501_abnormal_skin_physiology | 0.91753077 |
| 63 | MP0009840_abnormal_foam_cell | 0.91414711 |
| 64 | MP0005409_darkened_coat_color | 0.90895855 |
| 65 | MP0000013_abnormal_adipose_tissue | 0.90104324 |
| 66 | MP0005266_abnormal_metabolism | 0.88763651 |
| 67 | MP0005670_abnormal_white_adipose | 0.88730387 |
| 68 | MP0002295_abnormal_pulmonary_circulatio | 0.88280258 |
| 69 | MP0003878_abnormal_ear_physiology | 0.87817480 |
| 70 | MP0005377_hearing/vestibular/ear_phenot | 0.87817480 |
| 71 | MP0002254_reproductive_system_inflammat | 0.83795583 |
| 72 | MP0005167_abnormal_blood-brain_barrier | 0.74761925 |
| 73 | MP0003567_abnormal_fetal_cardiomyocyte | 0.73168747 |
| 74 | MP0003806_abnormal_nucleotide_metabolis | 0.72774994 |
| 75 | MP0000266_abnormal_heart_morphology | 0.72113905 |
| 76 | MP0005423_abnormal_somatic_nervous | 0.71895717 |
| 77 | MP0003566_abnormal_cell_adhesion | 0.71241281 |
| 78 | MP0006035_abnormal_mitochondrial_morpho | 0.69217351 |
| 79 | MP0001661_extended_life_span | 0.68201638 |
| 80 | MP0004270_analgesia | 0.67269869 |
| 81 | MP0005187_abnormal_penis_morphology | 0.64233372 |
| 82 | MP0002249_abnormal_larynx_morphology | 0.64141048 |
| 83 | MP0000467_abnormal_esophagus_morphology | 0.63875136 |
| 84 | MP0002090_abnormal_vision | 0.60922551 |
| 85 | MP0002060_abnormal_skin_morphology | 0.59682095 |
| 86 | MP0008961_abnormal_basal_metabolism | 0.59577525 |
| 87 | MP0002925_abnormal_cardiovascular_devel | 0.58692685 |
| 88 | MP0002877_abnormal_melanocyte_morpholog | 0.58348081 |
| 89 | MP0004272_abnormal_basement_membrane | 0.57713519 |
| 90 | MP0004043_abnormal_pH_regulation | 0.55853029 |
| 91 | MP0000383_abnormal_hair_follicle | 0.55671218 |
| 92 | MP0002078_abnormal_glucose_homeostasis | 0.55186403 |
| 93 | MP0005595_abnormal_vascular_smooth | 0.54646728 |
| 94 | MP0004858_abnormal_nervous_system | 0.53907026 |
| 95 | MP0001853_heart_inflammation | 0.52835959 |
| 96 | MP0003136_yellow_coat_color | 0.51822662 |
| 97 | MP0001299_abnormal_eye_distance/ | 0.51651691 |
| 98 | MP0005334_abnormal_fat_pad | 0.49910128 |
| 99 | MP0001614_abnormal_blood_vessel | 0.49889275 |
| 100 | MP0008438_abnormal_cutaneous_collagen | 0.49776001 |
| 101 | MP0006054_spinal_hemorrhage | 0.49192466 |
| 102 | MP0010234_abnormal_vibrissa_follicle | 0.48311975 |
| 103 | MP0001243_abnormal_dermal_layer | 0.47930910 |
| 104 | MP0005451_abnormal_body_composition | 0.47294990 |
| 105 | MP0003191_abnormal_cellular_cholesterol | 0.46263622 |
| 106 | MP0005165_increased_susceptibility_to | 0.44983479 |
| 107 | MP0003698_abnormal_male_reproductive | 0.44557655 |
| 108 | MP0008569_lethality_at_weaning | 0.43132778 |
| 109 | MP0003656_abnormal_erythrocyte_physiolo | 0.42845957 |
| 110 | MP0001216_abnormal_epidermal_layer | 0.42682780 |
| 111 | MP0003937_abnormal_limbs/digits/tail_de | 0.42172788 |
| 112 | MP0010771_integument_phenotype | 0.40761319 |
| 113 | MP0001529_abnormal_vocalization | 0.39319317 |
| 114 | MP0009115_abnormal_fat_cell | 0.39065939 |
| 115 | MP0005319_abnormal_enzyme/_coenzyme | 0.38939102 |
| 116 | MP0000230_abnormal_systemic_arterial | 0.38489436 |
| 117 | MP0002128_abnormal_blood_circulation | 0.37707019 |
| 118 | MP0001849_ear_inflammation | 0.37293342 |
| 119 | MP0002909_abnormal_adrenal_gland | 0.37196121 |
| 120 | MP0005452_abnormal_adipose_tissue | 0.36934601 |
| 121 | MP0000427_abnormal_hair_cycle | 0.36679460 |
| 122 | MP0003045_fibrosis | 0.35830781 |
| 123 | MP0010678_abnormal_skin_adnexa | 0.35072620 |
| 124 | MP0002896_abnormal_bone_mineralization | 0.34865261 |
| 125 | MP0000647_abnormal_sebaceous_gland | 0.34811985 |
| 126 | MP0000049_abnormal_middle_ear | 0.34731121 |
| 127 | MP0003329_amyloid_beta_deposits | 0.34411368 |
| 128 | MP0004947_skin_inflammation | 0.34346167 |
| 129 | MP0003453_abnormal_keratinocyte_physiol | 0.34274235 |
| 130 | MP0008874_decreased_physiological_sensi | 0.33064629 |
| 131 | MP0003941_abnormal_skin_development | 0.32975768 |
| 132 | MP0001879_abnormal_lymphatic_vessel | 0.32465502 |
| 133 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.32397209 |
| 134 | MP0000377_abnormal_hair_follicle | 0.31581692 |
| 135 | MP0002653_abnormal_ependyma_morphology | 0.31335537 |
| 136 | MP0001915_intracranial_hemorrhage | 0.31310109 |
| 137 | MP0009250_abnormal_appendicular_skeleto | 0.30808557 |
| 138 | MP0009278_abnormal_bone_marrow | 0.30711609 |
| 139 | MP0003959_abnormal_lean_body | 0.30446348 |
| 140 | MP0003948_abnormal_gas_homeostasis | 0.30303580 |
| 141 | MP0009931_abnormal_skin_appearance | 0.30201844 |
| 142 | MP0004147_increased_porphyrin_level | 0.29623030 |
| 143 | MP0001784_abnormal_fluid_regulation | 0.28896695 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Muscle fiber inclusion bodies (HP:0100299) | 9.16019549 |
| 2 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 8.77843342 |
| 3 | Nemaline bodies (HP:0003798) | 8.19883702 |
| 4 | Exercise-induced myalgia (HP:0003738) | 8.12846407 |
| 5 | Exercise-induced muscle cramps (HP:0003710) | 7.20679731 |
| 6 | Type 1 muscle fiber predominance (HP:0003803) | 7.08283743 |
| 7 | Distal arthrogryposis (HP:0005684) | 6.34616035 |
| 8 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.32124651 |
| 9 | Calf muscle hypertrophy (HP:0008981) | 6.06985178 |
| 10 | Muscle fiber splitting (HP:0003555) | 5.85166977 |
| 11 | Myopathic facies (HP:0002058) | 5.75011082 |
| 12 | Hyporeflexia of lower limbs (HP:0002600) | 5.38928864 |
| 13 | Round ear (HP:0100830) | 5.32431365 |
| 14 | Myoglobinuria (HP:0002913) | 5.24581855 |
| 15 | Ulnar deviation of the wrist (HP:0003049) | 5.11333800 |
| 16 | Difficulty running (HP:0009046) | 5.02444186 |
| 17 | Increased connective tissue (HP:0009025) | 4.79346001 |
| 18 | EMG: myopathic abnormalities (HP:0003458) | 4.66930109 |
| 19 | Hypoplastic left heart (HP:0004383) | 4.66488479 |
| 20 | Aplasia of the musculature (HP:0100854) | 4.59506588 |
| 21 | Abnormality of the calf musculature (HP:0001430) | 4.57222166 |
| 22 | Calcaneovalgus deformity (HP:0001848) | 4.50865806 |
| 23 | Hypoplastic heart (HP:0001961) | 4.41291970 |
| 24 | Sudden death (HP:0001699) | 4.24192871 |
| 25 | Bradycardia (HP:0001662) | 4.12781185 |
| 26 | Rhabdomyolysis (HP:0003201) | 4.11565962 |
| 27 | Deformed tarsal bones (HP:0008119) | 4.02933834 |
| 28 | Absent phalangeal crease (HP:0006109) | 4.00431899 |
| 29 | Muscle stiffness (HP:0003552) | 3.99398758 |
| 30 | Abnormality of skeletal muscle fiber size (HP:0012084) | 3.93817710 |
| 31 | Subaortic stenosis (HP:0001682) | 3.82142580 |
| 32 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.82142580 |
| 33 | Myotonia (HP:0002486) | 3.80065584 |
| 34 | Abnormal EKG (HP:0003115) | 3.77306570 |
| 35 | Neck muscle weakness (HP:0000467) | 3.75347171 |
| 36 | Partial duplication of thumb phalanx (HP:0009944) | 3.63789412 |
| 37 | Rimmed vacuoles (HP:0003805) | 3.63050996 |
| 38 | Double outlet right ventricle (HP:0001719) | 3.61981970 |
| 39 | Congenital malformation of the right heart (HP:0011723) | 3.61981970 |
| 40 | Increased variability in muscle fiber diameter (HP:0003557) | 3.60191373 |
| 41 | Ventricular fibrillation (HP:0001663) | 3.58594184 |
| 42 | Ventricular tachycardia (HP:0004756) | 3.52700628 |
| 43 | Abnormal finger flexion creases (HP:0006143) | 3.34273385 |
| 44 | Difficulty climbing stairs (HP:0003551) | 3.33824839 |
| 45 | Frequent falls (HP:0002359) | 3.30782590 |
| 46 | Areflexia of lower limbs (HP:0002522) | 3.22547082 |
| 47 | Asymmetric septal hypertrophy (HP:0001670) | 3.21670937 |
| 48 | Left ventricular hypertrophy (HP:0001712) | 3.21235874 |
| 49 | Partial duplication of the phalanx of hand (HP:0009999) | 3.09399607 |
| 50 | Anomalous pulmonary venous return (HP:0010772) | 3.05942892 |
| 51 | Right ventricular cardiomyopathy (HP:0011663) | 3.03839726 |
| 52 | Distal lower limb muscle weakness (HP:0009053) | 2.92995761 |
| 53 | Muscle fiber atrophy (HP:0100295) | 2.79874229 |
| 54 | Type 2 muscle fiber atrophy (HP:0003554) | 2.67864959 |
| 55 | Lipoatrophy (HP:0100578) | 2.66543857 |
| 56 | Malignant hyperthermia (HP:0002047) | 2.66400419 |
| 57 | Abnormality of the calcaneus (HP:0008364) | 2.66303030 |
| 58 | Facial diplegia (HP:0001349) | 2.64399610 |
| 59 | Abnormality of the pulmonary veins (HP:0011718) | 2.60227074 |
| 60 | Abnormality of the tricuspid valve (HP:0001702) | 2.58930552 |
| 61 | Wrist flexion contracture (HP:0001239) | 2.57785335 |
| 62 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.50670610 |
| 63 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.50475937 |
| 64 | Abnormality of the neuromuscular junction (HP:0003398) | 2.49966954 |
| 65 | Fatigable weakness (HP:0003473) | 2.49966954 |
| 66 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.48894699 |
| 67 | Dilated cardiomyopathy (HP:0001644) | 2.46129474 |
| 68 | Distal lower limb amyotrophy (HP:0008944) | 2.45883534 |
| 69 | EMG: neuropathic changes (HP:0003445) | 2.44568839 |
| 70 | Scapular winging (HP:0003691) | 2.44223460 |
| 71 | Generalized muscle weakness (HP:0003324) | 2.37336297 |
| 72 | Abnormality of the aortic arch (HP:0012303) | 2.32345981 |
| 73 | Spinal rigidity (HP:0003306) | 2.30672470 |
| 74 | Muscular dystrophy (HP:0003560) | 2.30405302 |
| 75 | Hyperkalemia (HP:0002153) | 2.28951137 |
| 76 | Atrial fibrillation (HP:0005110) | 2.28590662 |
| 77 | Pelvic girdle muscle weakness (HP:0003749) | 2.28448357 |
| 78 | Shoulder girdle muscle weakness (HP:0003547) | 2.28168711 |
| 79 | Progressive external ophthalmoplegia (HP:0000590) | 2.28076486 |
| 80 | Slender build (HP:0001533) | 2.26968878 |
| 81 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.25975211 |
| 82 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.25975211 |
| 83 | Limb-girdle muscle atrophy (HP:0003797) | 2.23639333 |
| 84 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.20655908 |
| 85 | Gowers sign (HP:0003391) | 2.20433924 |
| 86 | Easy fatigability (HP:0003388) | 2.18536023 |
| 87 | Abnormal connection of the cardiac segments (HP:0011545) | 2.17739869 |
| 88 | Abnormal ventriculo-arterial connection (HP:0011563) | 2.17739869 |
| 89 | Transposition of the great arteries (HP:0001669) | 2.17739869 |
| 90 | Primary atrial arrhythmia (HP:0001692) | 2.12581123 |
| 91 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.09113847 |
| 92 | Paralysis (HP:0003470) | 2.07899221 |
| 93 | Bulbar palsy (HP:0001283) | 2.07238145 |
| 94 | Proximal amyotrophy (HP:0007126) | 2.06854935 |
| 95 | Palpitations (HP:0001962) | 2.04801742 |
| 96 | Supraventricular tachycardia (HP:0004755) | 2.04382455 |
| 97 | Hypoplastic ischia (HP:0003175) | 2.03441300 |
| 98 | Abnormality of the shoulder girdle musculature (HP:0001435) | 2.03203505 |
| 99 | Supraventricular arrhythmia (HP:0005115) | 1.99247643 |
| 100 | Absent epiphyses (HP:0010577) | 1.98882866 |
| 101 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.98882866 |
| 102 | Weak cry (HP:0001612) | 1.97963127 |
| 103 | Bundle branch block (HP:0011710) | 1.97785354 |
| 104 | Ventricular arrhythmia (HP:0004308) | 1.97567260 |
| 105 | Progressive muscle weakness (HP:0003323) | 1.95498382 |
| 106 | Periauricular skin pits (HP:0100277) | 1.93739927 |
| 107 | Preauricular pit (HP:0004467) | 1.93739927 |
| 108 | Limb-girdle muscle weakness (HP:0003325) | 1.91083410 |
| 109 | Conjunctival hamartoma (HP:0100780) | 1.87120211 |
| 110 | Pulmonary artery stenosis (HP:0004415) | 1.85681264 |
| 111 | Lower limb amyotrophy (HP:0007210) | 1.85626274 |
| 112 | Foot dorsiflexor weakness (HP:0009027) | 1.84133737 |
| 113 | Sudden cardiac death (HP:0001645) | 1.81667791 |
| 114 | Hip contracture (HP:0003273) | 1.80681648 |
| 115 | Abnormality of the foot musculature (HP:0001436) | 1.80202574 |
| 116 | Thin ribs (HP:0000883) | 1.79672115 |
| 117 | Prolonged QT interval (HP:0001657) | 1.79587927 |
| 118 | Heart block (HP:0012722) | 1.79495983 |
| 119 | Palmoplantar keratoderma (HP:0000982) | 1.79070548 |
| 120 | Cholelithiasis (HP:0001081) | 1.77654328 |
| 121 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.77057518 |
| 122 | Resting tremor (HP:0002322) | 1.75271586 |
| 123 | Abnormal atrioventricular conduction (HP:0005150) | 1.75251580 |
| 124 | Patent foramen ovale (HP:0001655) | 1.75010416 |
| 125 | Abnormality of the ischium (HP:0003174) | 1.74760083 |
| 126 | Abnormality of the thoracic spine (HP:0100711) | 1.74341543 |
| 127 | Waddling gait (HP:0002515) | 1.74198270 |
| 128 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.71591341 |
| 129 | Syncope (HP:0001279) | 1.70008761 |
| 130 | Ulnar deviation of finger (HP:0009465) | 1.69314547 |
| 131 | Ragged-red muscle fibers (HP:0003200) | 1.68807262 |
| 132 | Duplication of thumb phalanx (HP:0009942) | 1.67880627 |
| 133 | Achilles tendon contracture (HP:0001771) | 1.66729444 |
| 134 | Metatarsus adductus (HP:0001840) | 1.60879632 |
| 135 | Exercise intolerance (HP:0003546) | 1.57330843 |
| 136 | Abnormal gallbladder morphology (HP:0012437) | 1.56287380 |
| 137 | Ketoacidosis (HP:0001993) | 1.54466428 |
| 138 | Atrioventricular block (HP:0001678) | 1.53767042 |
| 139 | Fetal akinesia sequence (HP:0001989) | 1.50994418 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 8.29032281 |
| 2 | TTN | 6.93599206 |
| 3 | PHKG2 | 4.53794771 |
| 4 | PHKG1 | 4.53794771 |
| 5 | TESK1 | 4.10634189 |
| 6 | PIK3CG | 3.88050749 |
| 7 | NME1 | 3.53933859 |
| 8 | TRIB3 | 2.51166952 |
| 9 | PDK3 | 2.44402562 |
| 10 | PDK4 | 2.44402562 |
| 11 | NEK1 | 2.38892115 |
| 12 | MAP2K3 | 2.30285839 |
| 13 | DMPK | 2.20853814 |
| 14 | TESK2 | 2.06905508 |
| 15 | KDR | 1.98338810 |
| 16 | PINK1 | 1.84871340 |
| 17 | MAP3K7 | 1.84852588 |
| 18 | BCKDK | 1.67598594 |
| 19 | PDK2 | 1.57270172 |
| 20 | PIK3CA | 1.54292642 |
| 21 | PKN2 | 1.47704936 |
| 22 | MUSK | 1.46385224 |
| 23 | UHMK1 | 1.37980584 |
| 24 | MAPK12 | 1.34775261 |
| 25 | MAP3K3 | 1.30955921 |
| 26 | MAPKAPK3 | 1.24170637 |
| 27 | CASK | 1.18535334 |
| 28 | LMTK2 | 1.12534762 |
| 29 | MOS | 1.11934336 |
| 30 | MARK1 | 1.10140153 |
| 31 | MAP2K6 | 1.05515166 |
| 32 | STK24 | 1.05372334 |
| 33 | STK4 | 1.00699224 |
| 34 | MAP2K4 | 0.97061498 |
| 35 | STK38L | 0.96275437 |
| 36 | EPHA2 | 0.88316923 |
| 37 | MYLK | 0.87997116 |
| 38 | DDR2 | 0.83906826 |
| 39 | PLK4 | 0.82634407 |
| 40 | TAOK1 | 0.79884824 |
| 41 | STK38 | 0.79863739 |
| 42 | TRPM7 | 0.78042835 |
| 43 | PRKAA2 | 0.77638031 |
| 44 | EPHB1 | 0.76591469 |
| 45 | DYRK3 | 0.75114606 |
| 46 | RIPK1 | 0.71517795 |
| 47 | ILK | 0.71356278 |
| 48 | ERN1 | 0.71011245 |
| 49 | NEK9 | 0.69988250 |
| 50 | PRKCE | 0.69790844 |
| 51 | PRKG2 | 0.69414479 |
| 52 | PRKAA1 | 0.68486653 |
| 53 | TIE1 | 0.66859352 |
| 54 | DAPK3 | 0.66446384 |
| 55 | ZAK | 0.66045577 |
| 56 | MAP3K11 | 0.61859210 |
| 57 | MAPK11 | 0.60305769 |
| 58 | PRKD1 | 0.58465712 |
| 59 | RPS6KA2 | 0.56678449 |
| 60 | MAPK15 | 0.55761804 |
| 61 | ICK | 0.52637795 |
| 62 | AKT2 | 0.52620289 |
| 63 | TRIM28 | 0.51437468 |
| 64 | PAK4 | 0.50216754 |
| 65 | VRK2 | 0.50001321 |
| 66 | MAP3K9 | 0.48314917 |
| 67 | MAP3K5 | 0.47109038 |
| 68 | ARAF | 0.47051299 |
| 69 | CAMK2G | 0.46977847 |
| 70 | PLK2 | 0.46364394 |
| 71 | MTOR | 0.46284307 |
| 72 | PTK6 | 0.45498025 |
| 73 | ROCK1 | 0.44845226 |
| 74 | SMG1 | 0.44546166 |
| 75 | TAOK2 | 0.43998748 |
| 76 | DYRK1B | 0.43607314 |
| 77 | ERBB3 | 0.43524691 |
| 78 | PKN1 | 0.42978972 |
| 79 | SIK1 | 0.42747661 |
| 80 | ERBB4 | 0.42716560 |
| 81 | RPS6KB2 | 0.40565439 |
| 82 | PAK2 | 0.40138968 |
| 83 | LATS1 | 0.39116521 |
| 84 | LIMK1 | 0.38292505 |
| 85 | FER | 0.37942790 |
| 86 | CAMK1 | 0.37524760 |
| 87 | CAMK2D | 0.35662468 |
| 88 | TGFBR2 | 0.34452238 |
| 89 | BCR | 0.34017774 |
| 90 | MAP3K1 | 0.32445214 |
| 91 | CDK14 | 0.32026122 |
| 92 | MST1R | 0.30925516 |
| 93 | CAMK2B | 0.29548500 |
| 94 | PAK3 | 0.29323922 |
| 95 | SGK1 | 0.29013834 |
| 96 | PRKACB | 0.27352140 |
| 97 | CDK18 | 0.27070373 |
| 98 | TBK1 | 0.26264008 |
| 99 | MAP3K6 | 0.25615092 |
| 100 | CDK11A | 0.24939643 |
| 101 | PRKG1 | 0.24778570 |
| 102 | PRKACA | 0.24707837 |
| 103 | CDK15 | 0.24557709 |
| 104 | FGFR4 | 0.23304952 |
| 105 | PDPK1 | 0.22569655 |
| 106 | FGFR3 | 0.22065461 |
| 107 | CLK1 | 0.21539430 |
| 108 | INSRR | 0.21345075 |
| 109 | VRK1 | 0.20825571 |
| 110 | TYK2 | 0.19715551 |
| 111 | ROCK2 | 0.19500521 |
| 112 | LRRK2 | 0.18249774 |
| 113 | RPS6KA1 | 0.17147806 |
| 114 | GRK7 | 0.17098241 |
| 115 | CAMK2A | 0.16353531 |
| 116 | CAMK4 | 0.16127948 |
| 117 | RPS6KA3 | 0.15797559 |
| 118 | EEF2K | 0.15645820 |
| 119 | PDGFRA | 0.15492396 |
| 120 | MAPK4 | 0.15476122 |
| 121 | MAP2K1 | 0.15207910 |
| 122 | KSR2 | 0.15128915 |
| 123 | EPHA3 | 0.14844988 |
| 124 | FLT3 | 0.14715173 |
| 125 | CDC42BPA | 0.14372888 |
| 126 | PDK1 | 0.14079568 |
| 127 | PRKACG | 0.13716788 |
| 128 | MAPKAPK2 | 0.12417769 |
| 129 | JAK2 | 0.11937407 |
| 130 | RPS6KL1 | 0.11844207 |
| 131 | RPS6KC1 | 0.11844207 |
| 132 | PRKCH | 0.11625697 |
| 133 | MAP3K10 | 0.11536466 |
| 134 | JAK1 | 0.11013827 |
| 135 | LATS2 | 0.10711162 |
| 136 | PTK2B | 0.10673894 |
| 137 | MAPK7 | 0.10639277 |
| 138 | EPHB2 | 0.09813935 |
| 139 | RPS6KA6 | 0.09215454 |
| 140 | PRKD3 | 0.08846772 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.14337697 |
| 2 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.89017575 |
| 3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.85170494 |
| 4 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.76023503 |
| 5 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.57765004 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.47141232 |
| 7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 3.17887708 |
| 8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.79019634 |
| 9 | Carbon metabolism_Homo sapiens_hsa01200 | 2.33117455 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.25996952 |
| 11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.22981015 |
| 12 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.07575776 |
| 13 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.04276911 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 1.96220099 |
| 15 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.87763763 |
| 16 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.82717687 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.73385222 |
| 18 | Insulin resistance_Homo sapiens_hsa04931 | 1.68899308 |
| 19 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.66038180 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.65450373 |
| 21 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.64960782 |
| 22 | Viral myocarditis_Homo sapiens_hsa05416 | 1.58042959 |
| 23 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.57405501 |
| 24 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.56834908 |
| 25 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.53783867 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.37746055 |
| 27 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.37541004 |
| 28 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.26844119 |
| 29 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.15444517 |
| 30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.13062958 |
| 31 | Galactose metabolism_Homo sapiens_hsa00052 | 1.10799018 |
| 32 | Tight junction_Homo sapiens_hsa04530 | 1.10683501 |
| 33 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.10357008 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.03297012 |
| 35 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.02614553 |
| 36 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.00275128 |
| 37 | Circadian rhythm_Homo sapiens_hsa04710 | 0.96687907 |
| 38 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.95069977 |
| 39 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.93677979 |
| 40 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.92899503 |
| 41 | Focal adhesion_Homo sapiens_hsa04510 | 0.92374178 |
| 42 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89296137 |
| 43 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.82371508 |
| 44 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.82113022 |
| 45 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.79899324 |
| 46 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.78792534 |
| 47 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.77948083 |
| 48 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.75957451 |
| 49 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.72317577 |
| 50 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.72163686 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.70387187 |
| 52 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.68296537 |
| 53 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.66757771 |
| 54 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.66171065 |
| 55 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.65482268 |
| 56 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.65246850 |
| 57 | Renin secretion_Homo sapiens_hsa04924 | 0.62905660 |
| 58 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.62246559 |
| 59 | Gap junction_Homo sapiens_hsa04540 | 0.62234480 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61945556 |
| 61 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.61749361 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.60963182 |
| 63 | Proteasome_Homo sapiens_hsa03050 | 0.60917016 |
| 64 | Axon guidance_Homo sapiens_hsa04360 | 0.60290114 |
| 65 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.60089456 |
| 66 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.56574500 |
| 67 | Cocaine addiction_Homo sapiens_hsa05030 | 0.55886653 |
| 68 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.52305962 |
| 69 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.51127011 |
| 70 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.50596984 |
| 71 | Amoebiasis_Homo sapiens_hsa05146 | 0.49314061 |
| 72 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.48504011 |
| 73 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.48279908 |
| 74 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.48139293 |
| 75 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.47379339 |
| 76 | Prion diseases_Homo sapiens_hsa05020 | 0.46269397 |
| 77 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.45526494 |
| 78 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.44730522 |
| 79 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.44334445 |
| 80 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.44331951 |
| 81 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.43894770 |
| 82 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.41481889 |
| 83 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.41436139 |
| 84 | Bile secretion_Homo sapiens_hsa04976 | 0.41390546 |
| 85 | Adherens junction_Homo sapiens_hsa04520 | 0.41384952 |
| 86 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.40685874 |
| 87 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.40042988 |
| 88 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.40001415 |
| 89 | Platelet activation_Homo sapiens_hsa04611 | 0.39698515 |
| 90 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.37369676 |
| 91 | Salivary secretion_Homo sapiens_hsa04970 | 0.36784434 |
| 92 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.36081667 |
| 93 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.35838654 |
| 94 | GABAergic synapse_Homo sapiens_hsa04727 | 0.34928819 |
| 95 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.33649124 |
| 96 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.33378191 |
| 97 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.32657851 |
| 98 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.31972422 |
| 99 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.31295980 |
| 100 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.29740004 |
| 101 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.29629912 |
| 102 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.28859885 |
| 103 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.28246067 |
| 104 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.27899863 |
| 105 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.27074488 |
| 106 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26791573 |
| 107 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.26699470 |
| 108 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.25698831 |
| 109 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.25003149 |
| 110 | Insulin secretion_Homo sapiens_hsa04911 | 0.24337536 |
| 111 | Peroxisome_Homo sapiens_hsa04146 | 0.23801902 |
| 112 | Lysine degradation_Homo sapiens_hsa00310 | 0.22607842 |
| 113 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.20137548 |
| 114 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.18936083 |
| 115 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.15879753 |
| 116 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.14810092 |
| 117 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.14717958 |
| 118 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.13150547 |
| 119 | Circadian entrainment_Homo sapiens_hsa04713 | 0.11541141 |
| 120 | Legionellosis_Homo sapiens_hsa05134 | 0.11514719 |
| 121 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.10810745 |
| 122 | Salmonella infection_Homo sapiens_hsa05132 | 0.09269472 |
| 123 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.09023999 |
| 124 | Leishmaniasis_Homo sapiens_hsa05140 | 0.07849651 |
| 125 | Metabolic pathways_Homo sapiens_hsa01100 | 0.07413629 |
| 126 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.06846209 |
| 127 | Melanogenesis_Homo sapiens_hsa04916 | 0.06443005 |
| 128 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.04143239 |
| 129 | Long-term depression_Homo sapiens_hsa04730 | 0.03673904 |

