SBK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.90298891
2actin-mediated cell contraction (GO:0070252)9.21453019
3sarcoplasmic reticulum calcium ion transport (GO:0070296)9.10311621
4skeletal muscle contraction (GO:0003009)8.38355353
5plasma membrane repair (GO:0001778)7.99880758
6sarcomere organization (GO:0045214)7.82927566
7skeletal muscle adaptation (GO:0043501)7.30761798
8regulation of cardioblast differentiation (GO:0051890)7.24916147
9actin filament-based movement (GO:0030048)6.96843313
10myofibril assembly (GO:0030239)6.77528855
11cytidine deamination (GO:0009972)6.61747344
12cytidine metabolic process (GO:0046087)6.61747344
13cytidine catabolic process (GO:0006216)6.61747344
14receptor guanylyl cyclase signaling pathway (GO:0007168)6.47820145
15pyrimidine ribonucleoside catabolic process (GO:0046133)6.43166403
16striated muscle contraction (GO:0006941)6.30382389
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.29962454
18negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.29624231
19ventricular cardiac muscle cell development (GO:0055015)6.07504004
20potassium ion export (GO:0071435)5.76736535
21atrioventricular valve morphogenesis (GO:0003181)5.71749037
22regulation of relaxation of muscle (GO:1901077)5.59939614
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.55200141
24negative regulation of cardiac muscle hypertrophy (GO:0010614)5.54143341
25cardiac chamber formation (GO:0003207)5.48355125
26skeletal muscle fiber development (GO:0048741)5.47104212
27cardiac myofibril assembly (GO:0055003)5.42346969
28regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.36876681
29creatine metabolic process (GO:0006600)5.26653924
30carnitine shuttle (GO:0006853)5.25001087
31negative regulation of potassium ion transmembrane transport (GO:1901380)5.21114172
32actomyosin structure organization (GO:0031032)5.20919694
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.15692736
34regulation of cell proliferation involved in heart morphogenesis (GO:2000136)5.13921949
35cardiac muscle contraction (GO:0060048)5.06536235
36keratinization (GO:0031424)5.02736913
37regulation of the force of heart contraction (GO:0002026)5.01419029
38cardiac ventricle formation (GO:0003211)5.00969080
39muscle contraction (GO:0006936)4.99853024
40striated muscle atrophy (GO:0014891)4.98867475
41regulation of cell communication by electrical coupling (GO:0010649)4.94248495
42skeletal muscle tissue regeneration (GO:0043403)4.91163118
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.90475118
44endocardial cushion development (GO:0003197)4.88236579
45tricarboxylic acid cycle (GO:0006099)4.84030910
46response to muscle activity (GO:0014850)4.81613593
47cardiac muscle cell proliferation (GO:0060038)4.80589675
48atrial septum morphogenesis (GO:0060413)4.77428412
49striated muscle adaptation (GO:0014888)4.74797101
50regulation of secondary heart field cardioblast proliferation (GO:0003266)4.72273942
51regulation of cardioblast proliferation (GO:0003264)4.72273942
52regulation of acyl-CoA biosynthetic process (GO:0050812)4.66772927
53ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.66368636
54negative regulation of cytosolic calcium ion concentration (GO:0051481)4.62966801
55positive regulation of cardiac muscle cell proliferation (GO:0060045)4.61506380
56myotube cell development (GO:0014904)4.60923321
57positive regulation of cardiac muscle tissue growth (GO:0055023)4.56342139
58cardiac muscle cell development (GO:0055013)4.53813865
59muscle system process (GO:0003012)4.51973538
60fatty acid transmembrane transport (GO:1902001)4.50817030
61regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.49518083
62response to inactivity (GO:0014854)4.43095458
63negative regulation of heart growth (GO:0061117)4.38804920
64negative regulation of cardiac muscle tissue growth (GO:0055022)4.38804920
65regulation of cardiac muscle contraction (GO:0055117)4.37096323
66regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.36102516
67regulation of cardiac muscle cell contraction (GO:0086004)4.34220297
68glycogen catabolic process (GO:0005980)4.32405397
69cardiac cell development (GO:0055006)4.26853303
70cGMP biosynthetic process (GO:0006182)4.26107515
71regulation of coenzyme metabolic process (GO:0051196)4.24982538
72regulation of cofactor metabolic process (GO:0051193)4.24982538
73muscle atrophy (GO:0014889)4.24910503
74muscle fiber development (GO:0048747)4.19770967
75striated muscle cell proliferation (GO:0014855)4.11558115
76cell migration involved in heart development (GO:0060973)4.09794659
77cell communication involved in cardiac conduction (GO:0086065)4.05087936
78glucan catabolic process (GO:0009251)4.02619464
79positive regulation of heart growth (GO:0060421)4.01538419
80cardiac muscle hypertrophy (GO:0003300)3.98185440
81regulation of actin filament-based movement (GO:1903115)3.97493730
82muscle adaptation (GO:0043500)3.97153271
83regulation of skeletal muscle cell differentiation (GO:2001014)3.96640472
84striated muscle hypertrophy (GO:0014897)3.95075542
85regulation of heart morphogenesis (GO:2000826)3.92483883
86glycogen biosynthetic process (GO:0005978)3.90065808
87glucan biosynthetic process (GO:0009250)3.90065808
88carnitine transmembrane transport (GO:1902603)3.88614899
89heart contraction (GO:0060047)3.88599881
90heart process (GO:0003015)3.88599881
91negative regulation of muscle hypertrophy (GO:0014741)3.87629838
92striated muscle cell development (GO:0055002)3.86771972
93negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.83579374
94regulation of cardiac muscle cell proliferation (GO:0060043)3.81706704
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.81569903
96regulation of striated muscle contraction (GO:0006942)3.80015774
97regulation of sarcomere organization (GO:0060297)3.79623407
98regulation of cardiac muscle tissue growth (GO:0055021)3.73366453
99cellular polysaccharide catabolic process (GO:0044247)3.73250597
100regulation of heart contraction (GO:0008016)3.70447436
101positive regulation of cardiac muscle tissue development (GO:0055025)3.70344641
102polysaccharide catabolic process (GO:0000272)3.69786093
103muscle tissue morphogenesis (GO:0060415)3.65019077
104cardiac muscle tissue morphogenesis (GO:0055008)3.63969649
105positive regulation of action potential (GO:0045760)3.62736944
106desmosome organization (GO:0002934)3.62630333
107regulation of heart rate (GO:0002027)3.62456309
108ventricular cardiac muscle cell action potential (GO:0086005)3.61604108
109regulation of heart growth (GO:0060420)3.59921482
110adult heart development (GO:0007512)3.59735726
111negative regulation of potassium ion transport (GO:0043267)3.58920134
112muscle cell fate commitment (GO:0042693)3.57822880
113muscle hypertrophy (GO:0014896)3.56017019
114detection of calcium ion (GO:0005513)3.52946074
115amino-acid betaine transport (GO:0015838)3.51983358
116carnitine transport (GO:0015879)3.51983358
117cardiac muscle cell action potential involved in contraction (GO:0086002)3.51538614
118muscle cell proliferation (GO:0033002)3.47890741
119atrial cardiac muscle cell action potential (GO:0086014)3.47536086
120cardiac muscle cell action potential (GO:0086001)3.47403493
121bundle of His cell to Purkinje myocyte communication (GO:0086069)3.46849096
122cell communication by electrical coupling (GO:0010644)3.45700133
123regulation of sequestering of triglyceride (GO:0010889)3.45151117
124positive regulation of urine volume (GO:0035810)3.43263805
125cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42379676
126regulation of sulfur metabolic process (GO:0042762)3.42078667
127pericardium development (GO:0060039)3.41494083
128regulation of ATP catabolic process (GO:1903289)3.41407088
129regulation of ATPase activity (GO:0043462)3.41407088
130muscle cell cellular homeostasis (GO:0046716)3.39565602
131positive regulation of myotube differentiation (GO:0010831)3.39328105
132regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.36723528
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.36411006
134cardiac muscle tissue development (GO:0048738)3.36095669
135negative regulation of protein localization to cell surface (GO:2000009)3.34427983
136positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.32515634
137muscle cell development (GO:0055001)3.29847954
138regulation of membrane repolarization (GO:0060306)3.29497226
139cardiac muscle hypertrophy in response to stress (GO:0014898)3.28255626
140muscle hypertrophy in response to stress (GO:0003299)3.28255626
141cardiac muscle adaptation (GO:0014887)3.28255626
142hemidesmosome assembly (GO:0031581)3.28044918
143regulation of calcium ion transmembrane transporter activity (GO:1901019)3.27296680
144regulation of calcium ion transmembrane transport (GO:1903169)3.27296680
145glycogen metabolic process (GO:0005977)3.26269498
146outflow tract septum morphogenesis (GO:0003148)3.25291245
147regulation of cardiac muscle tissue development (GO:0055024)3.24414438
148cardiac septum development (GO:0003279)3.24227407
149regulation of heart rate by cardiac conduction (GO:0086091)3.20451649
1502-oxoglutarate metabolic process (GO:0006103)3.19449725
151glucan metabolic process (GO:0044042)3.19122624
152cellular glucan metabolic process (GO:0006073)3.19122624
153positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.15913248
154NADH metabolic process (GO:0006734)3.15784121
155heart trabecula formation (GO:0060347)3.13874223
156actin-myosin filament sliding (GO:0033275)11.2805332
157muscle filament sliding (GO:0030049)11.2805332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.66656480
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.48717783
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.19383201
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.42774836
5EZH2_22144423_ChIP-Seq_EOC_Human3.33416421
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.04661638
7TBX20_22328084_ChIP-Seq_HEART_Mouse2.99211017
8TBX20_22080862_ChIP-Seq_HEART_Mouse2.99211017
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.80390979
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.80210919
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.78854452
12ZNF263_19887448_ChIP-Seq_K562_Human2.77366963
13ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.67291320
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64454067
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41184856
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.36630040
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.34804547
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23146289
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.04668153
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04354303
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.01613893
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96284427
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.91632332
24CLOCK_20551151_ChIP-Seq_293T_Human1.88129494
25P63_26484246_Chip-Seq_KERATINOCYTES_Human1.86165648
26MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.84163634
27SMC4_20622854_ChIP-Seq_HELA_Human1.76102042
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75613293
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67813555
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66200897
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66107053
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59958271
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.59763500
34* CTCF_27219007_Chip-Seq_Bcells_Human1.56950948
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54184055
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52332866
37RACK7_27058665_Chip-Seq_MCF-7_Human1.49865753
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.49492655
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47875261
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.45813696
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.45134102
42CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41225618
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38152320
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.37344188
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37179622
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36313001
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35558190
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.34816431
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34562014
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34423355
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34352067
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33289546
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32952315
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31424440
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30609364
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30213133
57ISL1_27105846_Chip-Seq_CPCs_Mouse1.30022856
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29747200
59TP63_22573176_ChIP-Seq_HFKS_Human1.29740884
60KDM2B_26808549_Chip-Seq_DND41_Human1.28920945
61* LXR_22292898_ChIP-Seq_THP-1_Human1.26504436
62CTCF_21964334_ChIP-Seq_BJAB-B_Human1.24692432
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24117697
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23978816
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.22546198
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22367642
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22367642
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20986378
69GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19815766
70EGR1_19032775_ChIP-ChIP_M12_Human1.19005824
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18844383
72ATF3_27146783_Chip-Seq_COLON_Human1.18746307
73FOXH1_21741376_ChIP-Seq_ESCs_Human1.18431192
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16841992
75KDM2B_26808549_Chip-Seq_K562_Human1.16780617
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16376385
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15691092
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15653253
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14597810
80P68_20966046_ChIP-Seq_HELA_Human1.12448637
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12445050
82CJUN_26792858_Chip-Seq_BT549_Human1.11777243
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.11569140
84SA1_27219007_Chip-Seq_Bcells_Human1.11072585
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.10783149
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.10701049
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09813885
88OCT4_20526341_ChIP-Seq_ESCs_Human1.09450301
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06447488
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04414807
91RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04336972
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04239848
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04066776
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.04042208
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03437176
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.03107935
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01982030
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01763833
99TP53_23651856_ChIP-Seq_MEFs_Mouse1.01287069
100BCOR_27268052_Chip-Seq_Bcells_Human1.00912177
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.00784599
102BCL6_27268052_Chip-Seq_Bcells_Human1.00446615
103E2F1_20622854_ChIP-Seq_HELA_Human1.00290258
104SOX2_21211035_ChIP-Seq_LN229_Human0.99593207
105TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99341908
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98186734
107SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97782059
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97518715
109OCT4_19829295_ChIP-Seq_ESCs_Human0.97395258
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.96837644
111SPI1_20517297_ChIP-Seq_HL60_Human0.96792022
112STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96048632
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95922684
114MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95768844
115RXR_22158963_ChIP-Seq_LIVER_Mouse0.95648092
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95518328
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95008142
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94993481
119* RARB_24833708_ChIP-Seq_LIVER_Mouse0.94489343
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94228120
121DROSHA_22980978_ChIP-Seq_HELA_Human0.93998422
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93431882
123CTCF_21964334_Chip-Seq_Bcells_Human0.93044525
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93032762
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92878621
126NANOG_20526341_ChIP-Seq_ESCs_Human0.91385677
127AR_21572438_ChIP-Seq_LNCaP_Human0.91277239
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90893451
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.89811878
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.89294421
131GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88683232
132ZNF274_21170338_ChIP-Seq_K562_Hela0.88619733
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88356391
134CEBPB_22108803_ChIP-Seq_LS180_Human0.88264348
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.88240900
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.87448638
137TCF7_22412390_ChIP-Seq_EML_Mouse0.87447451
138* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86811394
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85830749
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85473920
141* RUNX1_27514584_Chip-Seq_MCF-7_Human0.85218623
142CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83972690
143GATA2_19941826_ChIP-Seq_K562_Human0.83959040
144SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83448786
145CREB1_26743006_Chip-Seq_LNCaP_Human0.83184890
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.83148766
147RXR_22108803_ChIP-Seq_LS180_Human0.82474583
148GATA1_22025678_ChIP-Seq_K562_Human0.81972892
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.81458460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.12381409
2MP0000751_myopathy5.69932711
3MP0000749_muscle_degeneration5.59925394
4MP0004145_abnormal_muscle_electrophysio5.13650345
5MP0002837_dystrophic_cardiac_calcinosis4.90360131
6MP0004036_abnormal_muscle_relaxation3.97848450
7MP0000747_muscle_weakness3.76120040
8MP0002106_abnormal_muscle_physiology3.62960166
9MP0004087_abnormal_muscle_fiber3.40685160
10MP0004084_abnormal_cardiac_muscle3.34823841
11MP0000759_abnormal_skeletal_muscle3.18594814
12MP0000750_abnormal_muscle_regeneration3.15857349
13MP0004130_abnormal_muscle_cell3.12157514
14MP0002269_muscular_atrophy3.00627127
15MP0005369_muscle_phenotype2.96298582
16MP0005620_abnormal_muscle_contractility2.93139643
17MP0005330_cardiomyopathy2.85127274
18MP0004215_abnormal_myocardial_fiber2.55557949
19MP0002972_abnormal_cardiac_muscle2.18163795
20MP0005410_abnormal_fertilization2.12896955
21MP0004233_abnormal_muscle_weight1.99940456
22MP0002332_abnormal_exercise_endurance1.94440628
23MP0005275_abnormal_skin_tensile1.93168375
24MP0004185_abnormal_adipocyte_glucose1.93099591
25MP0000733_abnormal_muscle_development1.88159449
26MP0004484_altered_response_of1.88128147
27MP0010630_abnormal_cardiac_muscle1.81050758
28MP0003279_aneurysm1.79160897
29MP0006036_abnormal_mitochondrial_physio1.77099686
30MP0008004_abnormal_stomach_pH1.76023788
31MP0002796_impaired_skin_barrier1.71678462
32MP0005385_cardiovascular_system_phenoty1.68526981
33MP0001544_abnormal_cardiovascular_syste1.68526981
34MP0005666_abnormal_adipose_tissue1.67659122
35MP0008775_abnormal_heart_ventricle1.55648242
36MP0001348_abnormal_lacrimal_gland1.54631306
37MP0003705_abnormal_hypodermis_morpholog1.52583545
38MP0003137_abnormal_impulse_conducting1.49776600
39MP0003221_abnormal_cardiomyocyte_apopto1.49144887
40MP0002234_abnormal_pharynx_morphology1.48160612
41MP0002108_abnormal_muscle_morphology1.45466039
42MP0003950_abnormal_plasma_membrane1.42821912
43MP0005503_abnormal_tendon_morphology1.41070582
44MP0004510_myositis1.40372380
45MP0002971_abnormal_brown_adipose1.35718119
46MP0005375_adipose_tissue_phenotype1.34809216
47MP0006138_congestive_heart_failure1.34143024
48MP0000767_abnormal_smooth_muscle1.33611715
49MP0009384_cardiac_valve_regurgitation1.26565753
50MP0000579_abnormal_nail_morphology1.25699143
51MP0005257_abnormal_intraocular_pressure1.24242855
52MP0005623_abnormal_meninges_morphology1.14040877
53MP0010030_abnormal_orbit_morphology1.11558738
54MP0003828_pulmonary_edema1.05810403
55MP0002127_abnormal_cardiovascular_syste0.96874129
56MP0010368_abnormal_lymphatic_system0.96153286
57MP0003011_delayed_dark_adaptation0.95280099
58MP0000003_abnormal_adipose_tissue0.94432635
59MP0000343_altered_response_to0.93775291
60MP0000762_abnormal_tongue_morphology0.92526813
61MP0004085_abnormal_heartbeat0.91963183
62MP0005501_abnormal_skin_physiology0.91753077
63MP0009840_abnormal_foam_cell0.91414711
64MP0005409_darkened_coat_color0.90895855
65MP0000013_abnormal_adipose_tissue0.90104324
66MP0005266_abnormal_metabolism0.88763651
67MP0005670_abnormal_white_adipose0.88730387
68MP0002295_abnormal_pulmonary_circulatio0.88280258
69MP0003878_abnormal_ear_physiology0.87817480
70MP0005377_hearing/vestibular/ear_phenot0.87817480
71MP0002254_reproductive_system_inflammat0.83795583
72MP0005167_abnormal_blood-brain_barrier0.74761925
73MP0003567_abnormal_fetal_cardiomyocyte0.73168747
74MP0003806_abnormal_nucleotide_metabolis0.72774994
75MP0000266_abnormal_heart_morphology0.72113905
76MP0005423_abnormal_somatic_nervous0.71895717
77MP0003566_abnormal_cell_adhesion0.71241281
78MP0006035_abnormal_mitochondrial_morpho0.69217351
79MP0001661_extended_life_span0.68201638
80MP0004270_analgesia0.67269869
81MP0005187_abnormal_penis_morphology0.64233372
82MP0002249_abnormal_larynx_morphology0.64141048
83MP0000467_abnormal_esophagus_morphology0.63875136
84MP0002090_abnormal_vision0.60922551
85MP0002060_abnormal_skin_morphology0.59682095
86MP0008961_abnormal_basal_metabolism0.59577525
87MP0002925_abnormal_cardiovascular_devel0.58692685
88MP0002877_abnormal_melanocyte_morpholog0.58348081
89MP0004272_abnormal_basement_membrane0.57713519
90MP0004043_abnormal_pH_regulation0.55853029
91MP0000383_abnormal_hair_follicle0.55671218
92MP0002078_abnormal_glucose_homeostasis0.55186403
93MP0005595_abnormal_vascular_smooth0.54646728
94MP0004858_abnormal_nervous_system0.53907026
95MP0001853_heart_inflammation0.52835959
96MP0003136_yellow_coat_color0.51822662
97MP0001299_abnormal_eye_distance/0.51651691
98MP0005334_abnormal_fat_pad0.49910128
99MP0001614_abnormal_blood_vessel0.49889275
100MP0008438_abnormal_cutaneous_collagen0.49776001
101MP0006054_spinal_hemorrhage0.49192466
102MP0010234_abnormal_vibrissa_follicle0.48311975
103MP0001243_abnormal_dermal_layer0.47930910
104MP0005451_abnormal_body_composition0.47294990
105MP0003191_abnormal_cellular_cholesterol0.46263622
106MP0005165_increased_susceptibility_to0.44983479
107MP0003698_abnormal_male_reproductive0.44557655
108MP0008569_lethality_at_weaning0.43132778
109MP0003656_abnormal_erythrocyte_physiolo0.42845957
110MP0001216_abnormal_epidermal_layer0.42682780
111MP0003937_abnormal_limbs/digits/tail_de0.42172788
112MP0010771_integument_phenotype0.40761319
113MP0001529_abnormal_vocalization0.39319317
114MP0009115_abnormal_fat_cell0.39065939
115MP0005319_abnormal_enzyme/_coenzyme0.38939102
116MP0000230_abnormal_systemic_arterial0.38489436
117MP0002128_abnormal_blood_circulation0.37707019
118MP0001849_ear_inflammation0.37293342
119MP0002909_abnormal_adrenal_gland0.37196121
120MP0005452_abnormal_adipose_tissue0.36934601
121MP0000427_abnormal_hair_cycle0.36679460
122MP0003045_fibrosis0.35830781
123MP0010678_abnormal_skin_adnexa0.35072620
124MP0002896_abnormal_bone_mineralization0.34865261
125MP0000647_abnormal_sebaceous_gland0.34811985
126MP0000049_abnormal_middle_ear0.34731121
127MP0003329_amyloid_beta_deposits0.34411368
128MP0004947_skin_inflammation0.34346167
129MP0003453_abnormal_keratinocyte_physiol0.34274235
130MP0008874_decreased_physiological_sensi0.33064629
131MP0003941_abnormal_skin_development0.32975768
132MP0001879_abnormal_lymphatic_vessel0.32465502
133MP0005584_abnormal_enzyme/coenzyme_acti0.32397209
134MP0000377_abnormal_hair_follicle0.31581692
135MP0002653_abnormal_ependyma_morphology0.31335537
136MP0001915_intracranial_hemorrhage0.31310109
137MP0009250_abnormal_appendicular_skeleto0.30808557
138MP0009278_abnormal_bone_marrow0.30711609
139MP0003959_abnormal_lean_body0.30446348
140MP0003948_abnormal_gas_homeostasis0.30303580
141MP0009931_abnormal_skin_appearance0.30201844
142MP0004147_increased_porphyrin_level0.29623030
143MP0001784_abnormal_fluid_regulation0.28896695

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.16019549
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.77843342
3Nemaline bodies (HP:0003798)8.19883702
4Exercise-induced myalgia (HP:0003738)8.12846407
5Exercise-induced muscle cramps (HP:0003710)7.20679731
6Type 1 muscle fiber predominance (HP:0003803)7.08283743
7Distal arthrogryposis (HP:0005684)6.34616035
8Muscle hypertrophy of the lower extremities (HP:0008968)6.32124651
9Calf muscle hypertrophy (HP:0008981)6.06985178
10Muscle fiber splitting (HP:0003555)5.85166977
11Myopathic facies (HP:0002058)5.75011082
12Hyporeflexia of lower limbs (HP:0002600)5.38928864
13Round ear (HP:0100830)5.32431365
14Myoglobinuria (HP:0002913)5.24581855
15Ulnar deviation of the wrist (HP:0003049)5.11333800
16Difficulty running (HP:0009046)5.02444186
17Increased connective tissue (HP:0009025)4.79346001
18EMG: myopathic abnormalities (HP:0003458)4.66930109
19Hypoplastic left heart (HP:0004383)4.66488479
20Aplasia of the musculature (HP:0100854)4.59506588
21Abnormality of the calf musculature (HP:0001430)4.57222166
22Calcaneovalgus deformity (HP:0001848)4.50865806
23Hypoplastic heart (HP:0001961)4.41291970
24Sudden death (HP:0001699)4.24192871
25Bradycardia (HP:0001662)4.12781185
26Rhabdomyolysis (HP:0003201)4.11565962
27Deformed tarsal bones (HP:0008119)4.02933834
28Absent phalangeal crease (HP:0006109)4.00431899
29Muscle stiffness (HP:0003552)3.99398758
30Abnormality of skeletal muscle fiber size (HP:0012084)3.93817710
31Subaortic stenosis (HP:0001682)3.82142580
32Abnormality of the left ventricular outflow tract (HP:0011103)3.82142580
33Myotonia (HP:0002486)3.80065584
34Abnormal EKG (HP:0003115)3.77306570
35Neck muscle weakness (HP:0000467)3.75347171
36Partial duplication of thumb phalanx (HP:0009944)3.63789412
37Rimmed vacuoles (HP:0003805)3.63050996
38Double outlet right ventricle (HP:0001719)3.61981970
39Congenital malformation of the right heart (HP:0011723)3.61981970
40Increased variability in muscle fiber diameter (HP:0003557)3.60191373
41Ventricular fibrillation (HP:0001663)3.58594184
42Ventricular tachycardia (HP:0004756)3.52700628
43Abnormal finger flexion creases (HP:0006143)3.34273385
44Difficulty climbing stairs (HP:0003551)3.33824839
45Frequent falls (HP:0002359)3.30782590
46Areflexia of lower limbs (HP:0002522)3.22547082
47Asymmetric septal hypertrophy (HP:0001670)3.21670937
48Left ventricular hypertrophy (HP:0001712)3.21235874
49Partial duplication of the phalanx of hand (HP:0009999)3.09399607
50Anomalous pulmonary venous return (HP:0010772)3.05942892
51Right ventricular cardiomyopathy (HP:0011663)3.03839726
52Distal lower limb muscle weakness (HP:0009053)2.92995761
53Muscle fiber atrophy (HP:0100295)2.79874229
54Type 2 muscle fiber atrophy (HP:0003554)2.67864959
55Lipoatrophy (HP:0100578)2.66543857
56Malignant hyperthermia (HP:0002047)2.66400419
57Abnormality of the calcaneus (HP:0008364)2.66303030
58Facial diplegia (HP:0001349)2.64399610
59Abnormality of the pulmonary veins (HP:0011718)2.60227074
60Abnormality of the tricuspid valve (HP:0001702)2.58930552
61Wrist flexion contracture (HP:0001239)2.57785335
62Aplasia/Hypoplasia involving the musculature (HP:0001460)2.50670610
63Mildly elevated creatine phosphokinase (HP:0008180)2.50475937
64Abnormality of the neuromuscular junction (HP:0003398)2.49966954
65Fatigable weakness (HP:0003473)2.49966954
66Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48894699
67Dilated cardiomyopathy (HP:0001644)2.46129474
68Distal lower limb amyotrophy (HP:0008944)2.45883534
69EMG: neuropathic changes (HP:0003445)2.44568839
70Scapular winging (HP:0003691)2.44223460
71Generalized muscle weakness (HP:0003324)2.37336297
72Abnormality of the aortic arch (HP:0012303)2.32345981
73Spinal rigidity (HP:0003306)2.30672470
74Muscular dystrophy (HP:0003560)2.30405302
75Hyperkalemia (HP:0002153)2.28951137
76Atrial fibrillation (HP:0005110)2.28590662
77Pelvic girdle muscle weakness (HP:0003749)2.28448357
78Shoulder girdle muscle weakness (HP:0003547)2.28168711
79Progressive external ophthalmoplegia (HP:0000590)2.28076486
80Slender build (HP:0001533)2.26968878
81Abnormality of the musculature of the pelvis (HP:0001469)2.25975211
82Abnormality of the hip-girdle musculature (HP:0001445)2.25975211
83Limb-girdle muscle atrophy (HP:0003797)2.23639333
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.20655908
85Gowers sign (HP:0003391)2.20433924
86Easy fatigability (HP:0003388)2.18536023
87Abnormal connection of the cardiac segments (HP:0011545)2.17739869
88Abnormal ventriculo-arterial connection (HP:0011563)2.17739869
89Transposition of the great arteries (HP:0001669)2.17739869
90Primary atrial arrhythmia (HP:0001692)2.12581123
91Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09113847
92Paralysis (HP:0003470)2.07899221
93Bulbar palsy (HP:0001283)2.07238145
94Proximal amyotrophy (HP:0007126)2.06854935
95Palpitations (HP:0001962)2.04801742
96Supraventricular tachycardia (HP:0004755)2.04382455
97Hypoplastic ischia (HP:0003175)2.03441300
98Abnormality of the shoulder girdle musculature (HP:0001435)2.03203505
99Supraventricular arrhythmia (HP:0005115)1.99247643
100Absent epiphyses (HP:0010577)1.98882866
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98882866
102Weak cry (HP:0001612)1.97963127
103Bundle branch block (HP:0011710)1.97785354
104Ventricular arrhythmia (HP:0004308)1.97567260
105Progressive muscle weakness (HP:0003323)1.95498382
106Periauricular skin pits (HP:0100277)1.93739927
107Preauricular pit (HP:0004467)1.93739927
108Limb-girdle muscle weakness (HP:0003325)1.91083410
109Conjunctival hamartoma (HP:0100780)1.87120211
110Pulmonary artery stenosis (HP:0004415)1.85681264
111Lower limb amyotrophy (HP:0007210)1.85626274
112Foot dorsiflexor weakness (HP:0009027)1.84133737
113Sudden cardiac death (HP:0001645)1.81667791
114Hip contracture (HP:0003273)1.80681648
115Abnormality of the foot musculature (HP:0001436)1.80202574
116Thin ribs (HP:0000883)1.79672115
117Prolonged QT interval (HP:0001657)1.79587927
118Heart block (HP:0012722)1.79495983
119Palmoplantar keratoderma (HP:0000982)1.79070548
120Cholelithiasis (HP:0001081)1.77654328
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77057518
122Resting tremor (HP:0002322)1.75271586
123Abnormal atrioventricular conduction (HP:0005150)1.75251580
124Patent foramen ovale (HP:0001655)1.75010416
125Abnormality of the ischium (HP:0003174)1.74760083
126Abnormality of the thoracic spine (HP:0100711)1.74341543
127Waddling gait (HP:0002515)1.74198270
128Respiratory insufficiency due to muscle weakness (HP:0002747)1.71591341
129Syncope (HP:0001279)1.70008761
130Ulnar deviation of finger (HP:0009465)1.69314547
131Ragged-red muscle fibers (HP:0003200)1.68807262
132Duplication of thumb phalanx (HP:0009942)1.67880627
133Achilles tendon contracture (HP:0001771)1.66729444
134Metatarsus adductus (HP:0001840)1.60879632
135Exercise intolerance (HP:0003546)1.57330843
136Abnormal gallbladder morphology (HP:0012437)1.56287380
137Ketoacidosis (HP:0001993)1.54466428
138Atrioventricular block (HP:0001678)1.53767042
139Fetal akinesia sequence (HP:0001989)1.50994418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.29032281
2TTN6.93599206
3PHKG24.53794771
4PHKG14.53794771
5TESK14.10634189
6PIK3CG3.88050749
7NME13.53933859
8TRIB32.51166952
9PDK32.44402562
10PDK42.44402562
11NEK12.38892115
12MAP2K32.30285839
13DMPK2.20853814
14TESK22.06905508
15KDR1.98338810
16PINK11.84871340
17MAP3K71.84852588
18BCKDK1.67598594
19PDK21.57270172
20PIK3CA1.54292642
21PKN21.47704936
22MUSK1.46385224
23UHMK11.37980584
24MAPK121.34775261
25MAP3K31.30955921
26MAPKAPK31.24170637
27CASK1.18535334
28LMTK21.12534762
29MOS1.11934336
30MARK11.10140153
31MAP2K61.05515166
32STK241.05372334
33STK41.00699224
34MAP2K40.97061498
35STK38L0.96275437
36EPHA20.88316923
37MYLK0.87997116
38DDR20.83906826
39PLK40.82634407
40TAOK10.79884824
41STK380.79863739
42TRPM70.78042835
43PRKAA20.77638031
44EPHB10.76591469
45DYRK30.75114606
46RIPK10.71517795
47ILK0.71356278
48ERN10.71011245
49NEK90.69988250
50PRKCE0.69790844
51PRKG20.69414479
52PRKAA10.68486653
53TIE10.66859352
54DAPK30.66446384
55ZAK0.66045577
56MAP3K110.61859210
57MAPK110.60305769
58PRKD10.58465712
59RPS6KA20.56678449
60MAPK150.55761804
61ICK0.52637795
62AKT20.52620289
63TRIM280.51437468
64PAK40.50216754
65VRK20.50001321
66MAP3K90.48314917
67MAP3K50.47109038
68ARAF0.47051299
69CAMK2G0.46977847
70PLK20.46364394
71MTOR0.46284307
72PTK60.45498025
73ROCK10.44845226
74SMG10.44546166
75TAOK20.43998748
76DYRK1B0.43607314
77ERBB30.43524691
78PKN10.42978972
79SIK10.42747661
80ERBB40.42716560
81RPS6KB20.40565439
82PAK20.40138968
83LATS10.39116521
84LIMK10.38292505
85FER0.37942790
86CAMK10.37524760
87CAMK2D0.35662468
88TGFBR20.34452238
89BCR0.34017774
90MAP3K10.32445214
91CDK140.32026122
92MST1R0.30925516
93CAMK2B0.29548500
94PAK30.29323922
95SGK10.29013834
96PRKACB0.27352140
97CDK180.27070373
98TBK10.26264008
99MAP3K60.25615092
100CDK11A0.24939643
101PRKG10.24778570
102PRKACA0.24707837
103CDK150.24557709
104FGFR40.23304952
105PDPK10.22569655
106FGFR30.22065461
107CLK10.21539430
108INSRR0.21345075
109VRK10.20825571
110TYK20.19715551
111ROCK20.19500521
112LRRK20.18249774
113RPS6KA10.17147806
114GRK70.17098241
115CAMK2A0.16353531
116CAMK40.16127948
117RPS6KA30.15797559
118EEF2K0.15645820
119PDGFRA0.15492396
120MAPK40.15476122
121MAP2K10.15207910
122KSR20.15128915
123EPHA30.14844988
124FLT30.14715173
125CDC42BPA0.14372888
126PDK10.14079568
127PRKACG0.13716788
128MAPKAPK20.12417769
129JAK20.11937407
130RPS6KL10.11844207
131RPS6KC10.11844207
132PRKCH0.11625697
133MAP3K100.11536466
134JAK10.11013827
135LATS20.10711162
136PTK2B0.10673894
137MAPK70.10639277
138EPHB20.09813935
139RPS6KA60.09215454
140PRKD30.08846772

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.14337697
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.89017575
3Cardiac muscle contraction_Homo sapiens_hsa042603.85170494
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.76023503
5Dilated cardiomyopathy_Homo sapiens_hsa054143.57765004
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47141232
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.17887708
8Propanoate metabolism_Homo sapiens_hsa006402.79019634
9Carbon metabolism_Homo sapiens_hsa012002.33117455
10Parkinsons disease_Homo sapiens_hsa050122.25996952
11Fatty acid degradation_Homo sapiens_hsa000712.22981015
12Oxidative phosphorylation_Homo sapiens_hsa001902.07575776
13Starch and sucrose metabolism_Homo sapiens_hsa005002.04276911
14Alzheimers disease_Homo sapiens_hsa050101.96220099
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87763763
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.82717687
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73385222
18Insulin resistance_Homo sapiens_hsa049311.68899308
19Fatty acid metabolism_Homo sapiens_hsa012121.66038180
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65450373
21Glucagon signaling pathway_Homo sapiens_hsa049221.64960782
22Viral myocarditis_Homo sapiens_hsa054161.58042959
23Insulin signaling pathway_Homo sapiens_hsa049101.57405501
24Pyruvate metabolism_Homo sapiens_hsa006201.56834908
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53783867
26Oxytocin signaling pathway_Homo sapiens_hsa049211.37746055
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.37541004
28Biosynthesis of amino acids_Homo sapiens_hsa012301.26844119
29Calcium signaling pathway_Homo sapiens_hsa040201.15444517
30Huntingtons disease_Homo sapiens_hsa050161.13062958
31Galactose metabolism_Homo sapiens_hsa000521.10799018
32Tight junction_Homo sapiens_hsa045301.10683501
33AMPK signaling pathway_Homo sapiens_hsa041521.10357008
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03297012
35Phenylalanine metabolism_Homo sapiens_hsa003601.02614553
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00275128
37Circadian rhythm_Homo sapiens_hsa047100.96687907
38PPAR signaling pathway_Homo sapiens_hsa033200.95069977
39Fatty acid elongation_Homo sapiens_hsa000620.93677979
40Fructose and mannose metabolism_Homo sapiens_hsa000510.92899503
41Focal adhesion_Homo sapiens_hsa045100.92374178
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.89296137
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82371508
44Arginine and proline metabolism_Homo sapiens_hsa003300.82113022
45HIF-1 signaling pathway_Homo sapiens_hsa040660.79899324
46Arginine biosynthesis_Homo sapiens_hsa002200.78792534
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.77948083
48beta-Alanine metabolism_Homo sapiens_hsa004100.75957451
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72317577
50Fatty acid biosynthesis_Homo sapiens_hsa000610.72163686
51Butanoate metabolism_Homo sapiens_hsa006500.70387187
52VEGF signaling pathway_Homo sapiens_hsa043700.68296537
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66757771
54Ovarian steroidogenesis_Homo sapiens_hsa049130.66171065
55Gastric acid secretion_Homo sapiens_hsa049710.65482268
56GnRH signaling pathway_Homo sapiens_hsa049120.65246850
57Renin secretion_Homo sapiens_hsa049240.62905660
58Thyroid hormone synthesis_Homo sapiens_hsa049180.62246559
59Gap junction_Homo sapiens_hsa045400.62234480
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61945556
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61749361
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60963182
63Proteasome_Homo sapiens_hsa030500.60917016
64Axon guidance_Homo sapiens_hsa043600.60290114
65Fat digestion and absorption_Homo sapiens_hsa049750.60089456
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56574500
67Cocaine addiction_Homo sapiens_hsa050300.55886653
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52305962
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51127011
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50596984
71Amoebiasis_Homo sapiens_hsa051460.49314061
72Hedgehog signaling pathway_Homo sapiens_hsa043400.48504011
73Type II diabetes mellitus_Homo sapiens_hsa049300.48279908
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.48139293
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.47379339
76Prion diseases_Homo sapiens_hsa050200.46269397
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45526494
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44730522
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44334445
80Proteoglycans in cancer_Homo sapiens_hsa052050.44331951
81Hippo signaling pathway_Homo sapiens_hsa043900.43894770
82Linoleic acid metabolism_Homo sapiens_hsa005910.41481889
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41436139
84Bile secretion_Homo sapiens_hsa049760.41390546
85Adherens junction_Homo sapiens_hsa045200.41384952
86FoxO signaling pathway_Homo sapiens_hsa040680.40685874
87MAPK signaling pathway_Homo sapiens_hsa040100.40042988
88Tryptophan metabolism_Homo sapiens_hsa003800.40001415
89Platelet activation_Homo sapiens_hsa046110.39698515
90Tyrosine metabolism_Homo sapiens_hsa003500.37369676
91Salivary secretion_Homo sapiens_hsa049700.36784434
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36081667
93Pentose phosphate pathway_Homo sapiens_hsa000300.35838654
94GABAergic synapse_Homo sapiens_hsa047270.34928819
95mTOR signaling pathway_Homo sapiens_hsa041500.33649124
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33378191
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32657851
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31972422
99Renal cell carcinoma_Homo sapiens_hsa052110.31295980
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29740004
101ECM-receptor interaction_Homo sapiens_hsa045120.29629912
102Toxoplasmosis_Homo sapiens_hsa051450.28859885
103Cholinergic synapse_Homo sapiens_hsa047250.28246067
104Regulation of autophagy_Homo sapiens_hsa041400.27899863
105Inositol phosphate metabolism_Homo sapiens_hsa005620.27074488
106Olfactory transduction_Homo sapiens_hsa047400.26791573
107Glycerolipid metabolism_Homo sapiens_hsa005610.26699470
108Basal cell carcinoma_Homo sapiens_hsa052170.25698831
109Estrogen signaling pathway_Homo sapiens_hsa049150.25003149
110Insulin secretion_Homo sapiens_hsa049110.24337536
111Peroxisome_Homo sapiens_hsa041460.23801902
112Lysine degradation_Homo sapiens_hsa003100.22607842
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20137548
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18936083
115Acute myeloid leukemia_Homo sapiens_hsa052210.15879753
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14810092
117cAMP signaling pathway_Homo sapiens_hsa040240.14717958
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13150547
119Circadian entrainment_Homo sapiens_hsa047130.11541141
120Legionellosis_Homo sapiens_hsa051340.11514719
121Pancreatic secretion_Homo sapiens_hsa049720.10810745
122Salmonella infection_Homo sapiens_hsa051320.09269472
123Arachidonic acid metabolism_Homo sapiens_hsa005900.09023999
124Leishmaniasis_Homo sapiens_hsa051400.07849651
125Metabolic pathways_Homo sapiens_hsa011000.07413629
126Osteoclast differentiation_Homo sapiens_hsa043800.06846209
127Melanogenesis_Homo sapiens_hsa049160.06443005
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.04143239
129Long-term depression_Homo sapiens_hsa047300.03673904

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