SBK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.82985290
2regulation of relaxation of muscle (GO:1901077)7.24322645
3cardiac myofibril assembly (GO:0055003)7.21895738
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.15351886
5negative regulation of potassium ion transmembrane transport (GO:1901380)6.56411483
6sarcoplasmic reticulum calcium ion transport (GO:0070296)6.56387455
7regulation of sarcomere organization (GO:0060297)6.48217726
8myofibril assembly (GO:0030239)6.40885218
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.19062726
10tricarboxylic acid cycle (GO:0006099)6.18046179
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.94974521
12actin-myosin filament sliding (GO:0033275)5.92075302
13muscle filament sliding (GO:0030049)5.92075302
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.88597404
15cardiac muscle contraction (GO:0060048)5.78658853
16plasma membrane repair (GO:0001778)5.69644859
17regulation of actin filament-based movement (GO:1903115)5.65115611
18cardiac muscle hypertrophy (GO:0003300)5.63645280
19cardiac muscle cell development (GO:0055013)5.53703292
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.45645352
21striated muscle hypertrophy (GO:0014897)5.36261161
22adult heart development (GO:0007512)5.24291610
23cardiac cell development (GO:0055006)5.16393110
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.15414767
25heart trabecula formation (GO:0060347)5.13405835
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.02460426
27regulation of cell communication by electrical coupling (GO:0010649)4.99370291
28ventricular cardiac muscle cell action potential (GO:0086005)4.99006547
29creatine metabolic process (GO:0006600)4.97343952
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.92203398
31actomyosin structure organization (GO:0031032)4.90545531
32actin-mediated cell contraction (GO:0070252)4.87665443
33regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.82373458
34regulation of skeletal muscle contraction (GO:0014819)4.81193656
35regulation of acyl-CoA biosynthetic process (GO:0050812)4.77222840
36bundle of His cell to Purkinje myocyte communication (GO:0086069)4.76275076
37cardiac muscle hypertrophy in response to stress (GO:0014898)4.75970446
38muscle hypertrophy in response to stress (GO:0003299)4.75970446
39cardiac muscle adaptation (GO:0014887)4.75970446
40muscle hypertrophy (GO:0014896)4.71632463
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71023731
42regulation of striated muscle contraction (GO:0006942)4.67068584
43cardiac muscle tissue morphogenesis (GO:0055008)4.64484003
44striated muscle contraction (GO:0006941)4.61906731
45respiratory electron transport chain (GO:0022904)4.60678506
46regulation of membrane repolarization (GO:0060306)4.59838323
47regulation of the force of heart contraction (GO:0002026)4.52928394
48muscle adaptation (GO:0043500)4.50842285
49ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.50387863
50electron transport chain (GO:0022900)4.46359853
51regulation of cardiac muscle cell contraction (GO:0086004)4.43792348
52ATP synthesis coupled proton transport (GO:0015986)4.41409490
53energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41409490
54regulation of coenzyme metabolic process (GO:0051196)4.31272362
55regulation of cofactor metabolic process (GO:0051193)4.31272362
56cell communication involved in cardiac conduction (GO:0086065)4.28533618
57carnitine shuttle (GO:0006853)4.24037928
58regulation of cardiac muscle contraction (GO:0055117)4.21268214
59muscle tissue morphogenesis (GO:0060415)4.20444577
60negative regulation of protein localization to cell surface (GO:2000009)4.19768351
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05844700
62striated muscle atrophy (GO:0014891)4.00196028
63relaxation of cardiac muscle (GO:0055119)3.95194396
64heart process (GO:0003015)3.93969946
65heart contraction (GO:0060047)3.93969946
66skeletal muscle adaptation (GO:0043501)3.92764806
67negative regulation of potassium ion transport (GO:0043267)3.82950704
68negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.80005480
69negative regulation of calcium ion transmembrane transport (GO:1903170)3.80005480
70pinocytosis (GO:0006907)3.76065898
71NADH metabolic process (GO:0006734)3.75910835
72response to inactivity (GO:0014854)3.74406624
73fatty acid transmembrane transport (GO:1902001)3.72592163
74regulation of ATPase activity (GO:0043462)3.72224688
75regulation of ATP catabolic process (GO:1903289)3.72224688
762-oxoglutarate metabolic process (GO:0006103)3.68761079
77regulation of calcium ion transmembrane transport (GO:1903169)3.67766440
78regulation of calcium ion transmembrane transporter activity (GO:1901019)3.67766440
79actin filament-based movement (GO:0030048)3.66800728
80striated muscle adaptation (GO:0014888)3.64888224
81muscle atrophy (GO:0014889)3.62974579
82response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.62428981
83regulation of sulfur metabolic process (GO:0042762)3.61744939
84regulation of sequestering of triglyceride (GO:0010889)3.59523980
85response to muscle activity (GO:0014850)3.59308916
86positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.59291570
87negative regulation of cardiac muscle hypertrophy (GO:0010614)3.55208611
88ventricular cardiac muscle cell development (GO:0055015)3.54630648
89potassium ion export (GO:0071435)3.52919410
90cardiac muscle cell action potential involved in contraction (GO:0086002)3.51735645
91regulation of heart rate (GO:0002027)3.51679191
92cell communication by electrical coupling (GO:0010644)3.51333659
93positive regulation of cation channel activity (GO:2001259)3.50320244
94cardiac muscle cell action potential (GO:0086001)3.48097862
95pathway-restricted SMAD protein phosphorylation (GO:0060389)3.47888902
96detection of calcium ion (GO:0005513)3.46780608
97cardiac muscle cell proliferation (GO:0060038)3.46715476
98cardiac conduction (GO:0061337)3.46445635
99skeletal muscle contraction (GO:0003009)3.45866645
100oxidative phosphorylation (GO:0006119)3.45374721
101positive regulation of heart rate (GO:0010460)3.45262435
102regulation of heart contraction (GO:0008016)3.43420322
103atrioventricular valve morphogenesis (GO:0003181)3.38079339
104regulation of phospholipid biosynthetic process (GO:0071071)3.37951165
105receptor guanylyl cyclase signaling pathway (GO:0007168)3.31205333
106carnitine transmembrane transport (GO:1902603)3.29953690
107succinate metabolic process (GO:0006105)3.29881570
108oxygen transport (GO:0015671)3.28381973
109focal adhesion assembly (GO:0048041)3.27126334
110cell-substrate adherens junction assembly (GO:0007045)3.27126334
111fatty acid beta-oxidation (GO:0006635)3.25969585
112adrenergic receptor signaling pathway (GO:0071875)3.24696303
113regulation of cardioblast differentiation (GO:0051890)3.24623851
114negative regulation of muscle hypertrophy (GO:0014741)3.23604166
115striated muscle cell development (GO:0055002)3.23401751
116regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.12264175
117muscle contraction (GO:0006936)3.09449992
118negative regulation of necroptotic process (GO:0060546)3.09370133
119response to caffeine (GO:0031000)3.03784238
120positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.95013877
121muscle system process (GO:0003012)2.93892999
122striated muscle cell proliferation (GO:0014855)2.91948355
123regulation of acrosome reaction (GO:0060046)2.91864582
124regulation of female gonad development (GO:2000194)2.87381237
125regulation of NFAT protein import into nucleus (GO:0051532)2.85559924
126atrial septum morphogenesis (GO:0060413)2.83012230
127positive regulation of cardiac muscle hypertrophy (GO:0010613)2.80457437
128positive regulation of muscle hypertrophy (GO:0014742)2.80457437
129adherens junction assembly (GO:0034333)2.80006750
130activation of MAPKKK activity (GO:0000185)2.79797874
131glucose 6-phosphate metabolic process (GO:0051156)2.77557353
132regulation of cholesterol storage (GO:0010885)2.76854261
133regulation of membrane protein ectodomain proteolysis (GO:0051043)2.70779835
134negative regulation of heart growth (GO:0061117)2.68702673
135negative regulation of cardiac muscle tissue growth (GO:0055022)2.68702673
136response to epinephrine (GO:0071871)2.67660370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.99049920
2EZH2_22144423_ChIP-Seq_EOC_Human4.13784784
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.92050410
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.43174777
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03164457
6TBX20_22328084_ChIP-Seq_HEART_Mouse2.98136751
7TBX20_22080862_ChIP-Seq_HEART_Mouse2.98136751
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.81863668
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55989749
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.42798615
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.41955160
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25659336
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13528449
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.13268984
15MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.98456468
16RACK7_27058665_Chip-Seq_MCF-7_Human1.95254920
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94356378
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93108942
19NFIB_24661679_ChIP-Seq_LUNG_Mouse1.91747623
20LXR_22292898_ChIP-Seq_THP-1_Human1.85002035
21GATA1_22025678_ChIP-Seq_K562_Human1.83232502
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.81531100
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79287525
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75684837
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73474246
26DROSHA_22980978_ChIP-Seq_HELA_Human1.67147976
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62904366
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61937712
29VDR_22108803_ChIP-Seq_LS180_Human1.61873773
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61269807
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.59964452
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57882398
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.56611834
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55152118
35TCF7_22412390_ChIP-Seq_EML_Mouse1.55137342
36KDM2B_26808549_Chip-Seq_K562_Human1.55035996
37ATF3_27146783_Chip-Seq_COLON_Human1.54618401
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54111309
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53242008
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52587006
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51907077
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51440529
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50287688
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49380177
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49311072
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49098523
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49098523
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48332202
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46810126
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46052147
51KDM2B_26808549_Chip-Seq_DND41_Human1.40660194
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.39139168
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.39022817
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38637084
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37470993
56ZNF274_21170338_ChIP-Seq_K562_Hela1.36829813
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.36593463
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36055573
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36013608
60GATA4_21415370_ChIP-Seq_HL-1_Mouse1.35645601
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35616099
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33776458
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33534049
64GBX2_23144817_ChIP-Seq_PC3_Human1.32984432
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.32191172
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.31588275
67AR_21572438_ChIP-Seq_LNCaP_Human1.31050083
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30860065
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30209361
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29349650
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29156481
72ZNF263_19887448_ChIP-Seq_K562_Human1.28928241
73VDR_21846776_ChIP-Seq_THP-1_Human1.28404739
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28400404
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28340296
76GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.28106261
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26404637
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26324737
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24939976
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24687074
81SMC4_20622854_ChIP-Seq_HELA_Human1.20541187
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20052937
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19974141
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19732074
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.19529747
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17125649
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15993598
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15558238
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.15038488
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14279069
91SMAD4_21799915_ChIP-Seq_A2780_Human1.13536480
92MYC_22102868_ChIP-Seq_BL_Human1.13441762
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.12483724
94STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12101342
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.12003639
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.11138695
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10658636
98AR_21909140_ChIP-Seq_LNCAP_Human1.10524269
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10048462
100P68_20966046_ChIP-Seq_HELA_Human1.09445111
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.08757266
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07315330
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07279203
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07109246
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06096458
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.05778225
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05601869
108CTCF_27219007_Chip-Seq_Bcells_Human1.05297623
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05217144
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03280310
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03168786
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02043650
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.01157417
114TET1_21451524_ChIP-Seq_MESCs_Mouse1.00558408
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99858264
116EED_16625203_ChIP-ChIP_MESCs_Mouse0.99355536
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99329101
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98600456
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97920824
120FOXM1_23109430_ChIP-Seq_U2OS_Human0.97587873
121RNF2_27304074_Chip-Seq_ESCs_Mouse0.96752922
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.96675419
123SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95696947
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95403880
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.95008887
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94930067
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94782710
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94366397
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92303350
130BCAT_22108803_ChIP-Seq_LS180_Human0.91769963
131GATA1_19941826_ChIP-Seq_K562_Human0.91411670
132AHR_22903824_ChIP-Seq_MCF-7_Human0.91311294
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90827651
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.89993907
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89975257
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88686807
137EGR1_19032775_ChIP-ChIP_M12_Human0.87314126
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.87269835
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86915508
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.86664353
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86414057
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86047435
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85610161
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85610161
145CJUN_26792858_Chip-Seq_BT549_Human0.85594791
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85411348
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.85248579
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85194417
149TBL1_22424771_ChIP-Seq_293T_Human0.83127448
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.82684626
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82209231
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81993328
153TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81912980
154CLOCK_20551151_ChIP-Seq_293T_Human0.81750925
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81505293
156ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.80287309
157REST_18959480_ChIP-ChIP_MESCs_Mouse0.79872194
158TP63_22573176_ChIP-Seq_HFKS_Human0.79681598
159FOXA2_19822575_ChIP-Seq_HepG2_Human0.79252483
160TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78960940
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77948240
162STAT3_23295773_ChIP-Seq_U87_Human0.77422527
163OCT4_20526341_ChIP-Seq_ESCs_Human0.77412041
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77382264
165KLF4_19829295_ChIP-Seq_ESCs_Human0.77262406
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76755121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.98791721
2MP0003646_muscle_fatigue5.69182232
3MP0000751_myopathy5.42686174
4MP0004084_abnormal_cardiac_muscle5.32644194
5MP0004215_abnormal_myocardial_fiber4.67902857
6MP0004036_abnormal_muscle_relaxation4.02630939
7MP0000749_muscle_degeneration3.85362106
8MP0005330_cardiomyopathy3.75217843
9MP0008775_abnormal_heart_ventricle3.16199989
10MP0002972_abnormal_cardiac_muscle3.10529188
11MP0004484_altered_response_of3.01080295
12MP0004087_abnormal_muscle_fiber2.95087142
13MP0003137_abnormal_impulse_conducting2.79640265
14MP0005620_abnormal_muscle_contractility2.60785938
15MP0009840_abnormal_foam_cell2.60592453
16MP0004130_abnormal_muscle_cell2.60567284
17MP0001544_abnormal_cardiovascular_syste2.57237976
18MP0005385_cardiovascular_system_phenoty2.57237976
19MP0000750_abnormal_muscle_regeneration2.56440999
20MP0002106_abnormal_muscle_physiology2.45847706
21MP0004145_abnormal_muscle_electrophysio2.37001547
22MP0006138_congestive_heart_failure2.34155897
23MP0010630_abnormal_cardiac_muscle2.31213871
24MP0004085_abnormal_heartbeat2.28643877
25MP0002269_muscular_atrophy2.15971874
26MP0000747_muscle_weakness2.14145039
27MP0003828_pulmonary_edema2.09004564
28MP0005369_muscle_phenotype2.01088459
29MP0003221_abnormal_cardiomyocyte_apopto1.97562576
30MP0006036_abnormal_mitochondrial_physio1.95608476
31MP0000759_abnormal_skeletal_muscle1.95270579
32MP0003950_abnormal_plasma_membrane1.82316612
33MP0004510_myositis1.81709241
34MP0008004_abnormal_stomach_pH1.76673815
35MP0002332_abnormal_exercise_endurance1.71379154
36MP0002127_abnormal_cardiovascular_syste1.53048528
37MP0005076_abnormal_cell_differentiation1.45231099
38MP0005666_abnormal_adipose_tissue1.41718918
39MP0004233_abnormal_muscle_weight1.41615692
40MP0004185_abnormal_adipocyte_glucose1.29414733
41MP0010030_abnormal_orbit_morphology1.25992399
42MP0005165_increased_susceptibility_to1.25503951
43MP0005058_abnormal_lysosome_morphology1.17531274
44MP0000343_altered_response_to1.14887765
45MP0002139_abnormal_hepatobiliary_system1.11957894
46MP0004043_abnormal_pH_regulation1.04773148
47MP0001661_extended_life_span1.02438783
48MP0000266_abnormal_heart_morphology1.01718642
49MP0005375_adipose_tissue_phenotype1.01251702
50MP0002234_abnormal_pharynx_morphology0.99583541
51MP0006035_abnormal_mitochondrial_morpho0.99117350
52MP0000230_abnormal_systemic_arterial0.98589085
53MP0003705_abnormal_hypodermis_morpholog0.97014977
54MP0003453_abnormal_keratinocyte_physiol0.95733752
55MP0003303_peritoneal_inflammation0.93169301
56MP0002089_abnormal_postnatal_growth/wei0.89971118
57MP0002108_abnormal_muscle_morphology0.87193084
58MP0003567_abnormal_fetal_cardiomyocyte0.85107053
59MP0001849_ear_inflammation0.84790825
60MP0005451_abnormal_body_composition0.81760733
61MP0005670_abnormal_white_adipose0.80396572
62MP0005266_abnormal_metabolism0.80227848
63MP0010368_abnormal_lymphatic_system0.79100973
64MP0003880_abnormal_central_pattern0.77297411
65MP0002971_abnormal_brown_adipose0.73856862
66MP0000013_abnormal_adipose_tissue0.73014502
67MP0001730_embryonic_growth_arrest0.73013625
68MP0000003_abnormal_adipose_tissue0.72297074
69MP0005187_abnormal_penis_morphology0.70781148
70MP0001529_abnormal_vocalization0.69611240
71MP0002877_abnormal_melanocyte_morpholog0.67696996
72MP0005535_abnormal_body_temperature0.66517038
73MP0003984_embryonic_growth_retardation0.66373335
74MP0001915_intracranial_hemorrhage0.65008422
75MP0004924_abnormal_behavior0.63788628
76MP0005386_behavior/neurological_phenoty0.63788628
77MP0005023_abnormal_wound_healing0.63267174
78MP0002909_abnormal_adrenal_gland0.63209523
79MP0004859_abnormal_synaptic_plasticity0.62719018
80MP0004147_increased_porphyrin_level0.61853764
81MP0002088_abnormal_embryonic_growth/wei0.61439294
82MP0009278_abnormal_bone_marrow0.61290747
83MP0002925_abnormal_cardiovascular_devel0.61134049
84MP0005409_darkened_coat_color0.61121473
85MP0002998_abnormal_bone_remodeling0.60937835
86MP0002822_catalepsy0.60545902
87MP0003566_abnormal_cell_adhesion0.60010541
88MP0002128_abnormal_blood_circulation0.59432060
89MP0003091_abnormal_cell_migration0.58811937
90MP0000566_synostosis0.58578686
91MP0005167_abnormal_blood-brain_barrier0.58408869
92MP0002078_abnormal_glucose_homeostasis0.57482761
93MP0003718_maternal_effect0.56801860
94MP0005380_embryogenesis_phenotype0.56440281
95MP0001672_abnormal_embryogenesis/_devel0.56440281
96MP0008260_abnormal_autophagy0.55976456
97MP0005623_abnormal_meninges_morphology0.53193086
98MP0000579_abnormal_nail_morphology0.52520587
99MP0004270_analgesia0.52451738
100MP0008961_abnormal_basal_metabolism0.52301318
101MP0003329_amyloid_beta_deposits0.51516358
102MP0000733_abnormal_muscle_development0.48940898
103MP0002295_abnormal_pulmonary_circulatio0.48700892
104MP0009115_abnormal_fat_cell0.47684053
105MP0004272_abnormal_basement_membrane0.47648202
106MP0001614_abnormal_blood_vessel0.46224870
107MP0002163_abnormal_gland_morphology0.46214798
108MP0002272_abnormal_nervous_system0.45255959
109MP0001440_abnormal_grooming_behavior0.44650656
110MP0002896_abnormal_bone_mineralization0.44401200
111MP0000920_abnormal_myelination0.44080497
112MP0003195_calcinosis0.43936650
113MP0000767_abnormal_smooth_muscle0.42287951
114MP0005595_abnormal_vascular_smooth0.41724755
115MP0005257_abnormal_intraocular_pressure0.41299393
116MP0003656_abnormal_erythrocyte_physiolo0.41201015
117MP0003690_abnormal_glial_cell0.41017583
118MP0008569_lethality_at_weaning0.40907953
119MP0003075_altered_response_to0.40098839
120MP0003806_abnormal_nucleotide_metabolis0.39935009
121MP0003635_abnormal_synaptic_transmissio0.39523342
122MP0002254_reproductive_system_inflammat0.39089414
123MP0001879_abnormal_lymphatic_vessel0.38283489
124MP0006072_abnormal_retinal_apoptosis0.38136253
125MP0005164_abnormal_response_to0.37820267
126MP0005647_abnormal_sex_gland0.37321963
127MP0003879_abnormal_hair_cell0.36167997
128MP0003279_aneurysm0.35924507
129MP0005334_abnormal_fat_pad0.35597156
130MP0002064_seizures0.35587253
131MP0000249_abnormal_blood_vessel0.35357361
132MP0009745_abnormal_behavioral_response0.35318488
133MP0000858_altered_metastatic_potential0.35115840
134MP0009046_muscle_twitch0.35037561
135MP0002080_prenatal_lethality0.34785381
136MP0005584_abnormal_enzyme/coenzyme_acti0.34752343
137MP0002090_abnormal_vision0.34286756
138MP0005319_abnormal_enzyme/_coenzyme0.33210206
139MP0002118_abnormal_lipid_homeostasis0.32566150
140MP0008874_decreased_physiological_sensi0.32274362
141MP0005083_abnormal_biliary_tract0.30799974
142MP0004858_abnormal_nervous_system0.30646489
143MP0003633_abnormal_nervous_system0.30566045

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.01035831
2Calf muscle hypertrophy (HP:0008981)6.45746697
3Ventricular tachycardia (HP:0004756)6.11552169
4Muscle hypertrophy of the lower extremities (HP:0008968)6.01143763
5Atrial fibrillation (HP:0005110)5.93038475
6Exercise-induced myalgia (HP:0003738)5.74637622
7Primary atrial arrhythmia (HP:0001692)5.52192307
8Supraventricular tachycardia (HP:0004755)5.31458876
9Abnormality of the calf musculature (HP:0001430)5.25933250
10Muscle fiber splitting (HP:0003555)5.25595726
11Exercise-induced muscle cramps (HP:0003710)5.25008252
12Supraventricular arrhythmia (HP:0005115)5.18037663
13Hyporeflexia of lower limbs (HP:0002600)4.75642867
14Syncope (HP:0001279)4.71459224
15Myoglobinuria (HP:0002913)4.70102740
16Lipoatrophy (HP:0100578)4.67020252
17Bundle branch block (HP:0011710)4.63181703
18Right ventricular cardiomyopathy (HP:0011663)4.38773634
19Palpitations (HP:0001962)4.15576773
20Dilated cardiomyopathy (HP:0001644)4.09934882
21Prolonged QT interval (HP:0001657)4.09452340
22EMG: myopathic abnormalities (HP:0003458)4.05712526
23Asymmetric septal hypertrophy (HP:0001670)3.89277579
24Heart block (HP:0012722)3.86816241
25Acute necrotizing encephalopathy (HP:0006965)3.72163911
26Abnormal mitochondria in muscle tissue (HP:0008316)3.69308831
27Abnormality of the left ventricular outflow tract (HP:0011103)3.68762398
28Subaortic stenosis (HP:0001682)3.68762398
29Difficulty running (HP:0009046)3.64045453
30Abnormal atrioventricular conduction (HP:0005150)3.62447291
31Ventricular arrhythmia (HP:0004308)3.62283150
32Atrioventricular block (HP:0001678)3.58644460
33Increased connective tissue (HP:0009025)3.47392204
34Hepatic necrosis (HP:0002605)3.41833031
35Muscle fiber inclusion bodies (HP:0100299)3.35163724
36Rhabdomyolysis (HP:0003201)3.31733330
37Myotonia (HP:0002486)3.27287882
38Acute encephalopathy (HP:0006846)3.26764617
39Centrally nucleated skeletal muscle fibers (HP:0003687)3.24010231
40Ventricular fibrillation (HP:0001663)3.22090135
41Deep venous thrombosis (HP:0002625)3.17251681
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.15324195
43Progressive macrocephaly (HP:0004481)3.05593381
44Pheochromocytoma (HP:0002666)2.98762460
45Distal lower limb muscle weakness (HP:0009053)2.98672691
46Hepatocellular necrosis (HP:0001404)2.96532476
47Ketoacidosis (HP:0001993)2.94682118
48Left ventricular hypertrophy (HP:0001712)2.88159612
49Abnormal EKG (HP:0003115)2.83741636
50Hypoglycemic coma (HP:0001325)2.81205648
51Mitochondrial inheritance (HP:0001427)2.78718297
52Increased variability in muscle fiber diameter (HP:0003557)2.74892873
53Cerebral edema (HP:0002181)2.73516646
54Nemaline bodies (HP:0003798)2.72729057
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68265004
56Dicarboxylic aciduria (HP:0003215)2.68265004
57Increased CSF lactate (HP:0002490)2.67337448
58Neuroendocrine neoplasm (HP:0100634)2.61826262
59Bulbar palsy (HP:0001283)2.61737809
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59006868
61Abnormality of alanine metabolism (HP:0010916)2.59006868
62Hyperalaninemia (HP:0003348)2.59006868
63Difficulty climbing stairs (HP:0003551)2.58910557
64Mildly elevated creatine phosphokinase (HP:0008180)2.57695475
65Type 1 muscle fiber predominance (HP:0003803)2.56553552
66Abnormality of skeletal muscle fiber size (HP:0012084)2.54172548
67Muscle stiffness (HP:0003552)2.53664662
68Abnormality of fatty-acid metabolism (HP:0004359)2.45358978
69Areflexia of lower limbs (HP:0002522)2.43710821
70Limb-girdle muscle atrophy (HP:0003797)2.42299291
71Palmoplantar keratoderma (HP:0000982)2.42008103
72Distal lower limb amyotrophy (HP:0008944)2.41993848
73Increased muscle lipid content (HP:0009058)2.40550129
74Rimmed vacuoles (HP:0003805)2.39965580
75Myopathic facies (HP:0002058)2.38174149
76Gowers sign (HP:0003391)2.37414096
77Neck muscle weakness (HP:0000467)2.33497454
78Respiratory failure (HP:0002878)2.31849034
79Conjunctival hamartoma (HP:0100780)2.31567643
80Frequent falls (HP:0002359)2.29554509
81Exercise intolerance (HP:0003546)2.26776256
82Lactic acidosis (HP:0003128)2.24759872
83Foot dorsiflexor weakness (HP:0009027)2.17031205
84Increased intramyocellular lipid droplets (HP:0012240)2.16565497
85Ketosis (HP:0001946)2.14341833
86Abnormality of the foot musculature (HP:0001436)2.12455528
87Flat acetabular roof (HP:0003180)2.12446743
88Bradycardia (HP:0001662)2.07944149
89Round ear (HP:0100830)2.07451404
90Central scotoma (HP:0000603)2.06862152
91Lower limb amyotrophy (HP:0007210)2.05418368
92Hypoalphalipoproteinemia (HP:0003233)2.04450198
93Abnormality of the shoulder girdle musculature (HP:0001435)2.00968097
94Neoplasm of head and neck (HP:0012288)1.99373386
95Esophageal neoplasm (HP:0100751)1.99373386
96Sudden cardiac death (HP:0001645)1.98499393
97Nausea (HP:0002018)1.98347320
98Hyperinsulinemic hypoglycemia (HP:0000825)1.98202924
99Progressive muscle weakness (HP:0003323)1.97855866
100Distal upper limb amyotrophy (HP:0007149)1.96956253
101Upper limb amyotrophy (HP:0009129)1.96956253
102Facial diplegia (HP:0001349)1.96487989
103Neoplasm of the adrenal gland (HP:0100631)1.92528906
104Abnormality of glycolysis (HP:0004366)1.92466087
105Increased serum pyruvate (HP:0003542)1.92466087
106Ulnar deviation of the wrist (HP:0003049)1.91038045
107Skin nodule (HP:0200036)1.90959362
108Neonatal death (HP:0003811)1.90660219
109Ragged-red muscle fibers (HP:0003200)1.90318442
110Muscular dystrophy (HP:0003560)1.88544823
111Athetosis (HP:0002305)1.88310174
112Spinal rigidity (HP:0003306)1.84337830
113Generalized aminoaciduria (HP:0002909)1.83165714
114Scapular winging (HP:0003691)1.83053387
115Hamartoma of the eye (HP:0010568)1.81886409
116EMG: neuropathic changes (HP:0003445)1.80012838
117Dysmetric saccades (HP:0000641)1.79959387
118Joint hemorrhage (HP:0005261)1.79657840
119Congestive heart failure (HP:0001635)1.78727857
120Abnormality of the tricuspid valve (HP:0001702)1.78064200
121Back pain (HP:0003418)1.77215163
122Nuclear cataract (HP:0100018)1.75103458
123Generalized muscle weakness (HP:0003324)1.74021116
124Hypercholesterolemia (HP:0003124)1.70810880
125Aneurysm (HP:0002617)1.69046023
126Partial duplication of thumb phalanx (HP:0009944)1.68608787
127Abnormality of pain sensation (HP:0010832)1.66822020
128Impaired pain sensation (HP:0007328)1.66822020
129Proximal amyotrophy (HP:0007126)1.64219075
130Axonal loss (HP:0003447)1.64129441
131Achilles tendon contracture (HP:0001771)1.62271781
132Abnormality of the Achilles tendon (HP:0005109)1.61453684
133Cerebral aneurysm (HP:0004944)1.61284759
134Myocardial infarction (HP:0001658)1.60907504
135Malignant hyperthermia (HP:0002047)1.58779952
136Esophageal varix (HP:0002040)1.57517186
137Easy fatigability (HP:0003388)1.56134386
138Complement deficiency (HP:0004431)1.56107604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.79519206
2OBSCN4.60951161
3IRAK34.27656760
4PHKG23.98089785
5PHKG13.98089785
6LMTK23.68951599
7PDK43.41302054
8PDK33.41302054
9MST1R3.25690165
10MYLK3.08406646
11DMPK3.05678843
12MUSK2.35996046
13PINK12.30071782
14PDK22.27259966
15PKN22.21793462
16CDK122.06888963
17MET2.04372495
18EEF2K1.98514272
19EPHA21.95824176
20GRK71.90609159
21TAOK21.76491864
22PAK31.76476421
23SMG11.71222215
24BCKDK1.69058751
25TRIB31.68408894
26STK241.67718192
27PIK3CA1.62802103
28ERN11.58877041
29TAOK11.55319358
30CAMK2D1.54246058
31TIE11.51103841
32NEK11.47980013
33FGFR41.43867954
34MAP3K31.39691328
35SIK11.38047715
36EPHB11.34811762
37PRKD11.32427600
38ARAF1.31638073
39DDR21.25134782
40TYRO31.23460815
41PKN11.19453871
42STK391.15519580
43BMX1.14096154
44MAP3K71.14051774
45MAP3K101.05278039
46CAMK2A1.05148884
47MTOR1.04881412
48ILK1.00195971
49MAPK120.96713122
50WNK40.96181351
51EPHB20.95331934
52PTK20.94459792
53ROCK10.90624602
54PAK40.87943909
55ROCK20.86008351
56PRKAA20.82837765
57EPHA30.82014710
58CAMK40.80577213
59CDC42BPA0.80157908
60KSR20.79866614
61TBK10.79654439
62IRAK20.78546932
63PIM20.76541874
64PTK2B0.76236192
65CAMK2G0.74583155
66PRKAA10.74177779
67AKT20.73792724
68ERBB40.72974112
69CDK90.72401842
70DAPK30.72401484
71RIPK10.68494628
72MAP3K110.66114450
73WNK10.65862356
74PAK60.64468002
75CAMK10.63910509
76BRAF0.63497704
77FGFR30.60952070
78STK40.58131493
79PRKCE0.57511924
80MAP2K40.56847181
81MAP3K50.55876629
82ALK0.55551547
83PRPF4B0.53127425
84MAP3K130.53037724
85PRKACB0.52182893
86TRPM70.51221051
87CAMK2B0.51119698
88PDGFRA0.50860118
89MELK0.50667599
90INSRR0.50305052
91TNIK0.49786603
92RET0.48594536
93TGFBR20.47940806
94STK380.47306274
95CDK80.46226955
96SGK30.45834962
97MAPK40.45753980
98LATS20.45659217
99FGR0.45614467
100ICK0.44519236
101MAP3K40.43210733
102PDPK10.42932242
103PRKACA0.42100087
104MAP3K10.42011563
105MAPKAPK30.41624735
106NTRK30.41076773
107PIK3CG0.40426274
108RPS6KA10.40371247
109MAP3K80.40071201
110NEK90.39596350
111RPS6KB20.39543583
112LATS10.38284377
113CLK10.37797842
114PDK10.37468122
115MAPKAPK20.37376364
116PRKCH0.36725928
117MAP2K30.36426918
118NME10.34546815
119MOS0.33484962
120MAPK110.33330447
121MATK0.33063373
122PRKACG0.33058433
123MARK10.32443006
124EPHA40.32382854
125AURKA0.29908909
126CAMK1D0.29378215
127STK38L0.29369671
128NME20.29034984
129PRKG10.28557106
130CDK40.28545744
131UHMK10.28541282
132SGK10.28318755
133MARK20.27629828
134PDGFRB0.26185851
135MAP3K60.26077564
136RPS6KA60.25695438
137RPS6KA20.25653473
138FER0.25635321
139ABL20.25543823
140GRK50.24841160
141RPS6KA30.23247067
142PRKD20.23231204
143RPS6KL10.22646804
144RPS6KC10.22646804
145PRKG20.20741804
146MAP3K90.20728072
147LIMK10.19755448
148FLT30.19294824
149ADRBK10.19032470
150CASK0.18577144
151NTRK20.18205140
152MAP2K10.17591353

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.35253762
2Cardiac muscle contraction_Homo sapiens_hsa042604.07807911
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.60008617
4Oxidative phosphorylation_Homo sapiens_hsa001903.51569943
5Parkinsons disease_Homo sapiens_hsa050123.40599693
6Dilated cardiomyopathy_Homo sapiens_hsa054143.38232613
7Propanoate metabolism_Homo sapiens_hsa006403.21586636
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.11199851
9Fatty acid degradation_Homo sapiens_hsa000712.80153589
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.68446991
11Alzheimers disease_Homo sapiens_hsa050102.67585751
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67509781
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41646858
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.25491500
15Fatty acid metabolism_Homo sapiens_hsa012122.20476259
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.18548345
17Huntingtons disease_Homo sapiens_hsa050162.11550465
18Carbon metabolism_Homo sapiens_hsa012002.07797464
19Galactose metabolism_Homo sapiens_hsa000521.90400154
20Pentose phosphate pathway_Homo sapiens_hsa000301.83412163
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80584513
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75607866
23Fructose and mannose metabolism_Homo sapiens_hsa000511.72163913
24Pyruvate metabolism_Homo sapiens_hsa006201.67845027
25Adherens junction_Homo sapiens_hsa045201.66516748
26Other glycan degradation_Homo sapiens_hsa005111.66082635
27Butanoate metabolism_Homo sapiens_hsa006501.65631837
28Fatty acid elongation_Homo sapiens_hsa000621.61904184
29Complement and coagulation cascades_Homo sapiens_hsa046101.47437368
30Viral myocarditis_Homo sapiens_hsa054161.31594672
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28422277
32Bladder cancer_Homo sapiens_hsa052191.22149693
33Prion diseases_Homo sapiens_hsa050201.17836419
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05686248
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.05279188
36Calcium signaling pathway_Homo sapiens_hsa040200.98828369
37Oxytocin signaling pathway_Homo sapiens_hsa049210.93442878
38Proteoglycans in cancer_Homo sapiens_hsa052050.92767781
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90655037
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.90446192
41PPAR signaling pathway_Homo sapiens_hsa033200.88607317
42Notch signaling pathway_Homo sapiens_hsa043300.87573830
43Glucagon signaling pathway_Homo sapiens_hsa049220.85840502
44Arginine and proline metabolism_Homo sapiens_hsa003300.84933513
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.83638255
46TNF signaling pathway_Homo sapiens_hsa046680.82350245
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81521263
48Chronic myeloid leukemia_Homo sapiens_hsa052200.81386838
49beta-Alanine metabolism_Homo sapiens_hsa004100.81191144
50Arginine biosynthesis_Homo sapiens_hsa002200.79811731
51Circadian entrainment_Homo sapiens_hsa047130.77850153
52Insulin resistance_Homo sapiens_hsa049310.74380784
53Biosynthesis of amino acids_Homo sapiens_hsa012300.73081286
54Renin secretion_Homo sapiens_hsa049240.71906780
55Gastric acid secretion_Homo sapiens_hsa049710.70717492
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.69286410
57Starch and sucrose metabolism_Homo sapiens_hsa005000.68369372
58Insulin secretion_Homo sapiens_hsa049110.68185648
59Salmonella infection_Homo sapiens_hsa051320.67583589
60cAMP signaling pathway_Homo sapiens_hsa040240.66638756
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66106361
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64179443
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63965861
64Salivary secretion_Homo sapiens_hsa049700.62807337
65Tryptophan metabolism_Homo sapiens_hsa003800.62659471
66Morphine addiction_Homo sapiens_hsa050320.62414833
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62167071
68Insulin signaling pathway_Homo sapiens_hsa049100.62108264
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.60711786
70Malaria_Homo sapiens_hsa051440.60232730
71mTOR signaling pathway_Homo sapiens_hsa041500.60176669
72Type II diabetes mellitus_Homo sapiens_hsa049300.59329232
73Fatty acid biosynthesis_Homo sapiens_hsa000610.58975789
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58412019
75Ovarian steroidogenesis_Homo sapiens_hsa049130.57404211
76Pancreatic cancer_Homo sapiens_hsa052120.57377618
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57375555
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.57107339
79Peroxisome_Homo sapiens_hsa041460.56123582
80Lysosome_Homo sapiens_hsa041420.53480989
81Small cell lung cancer_Homo sapiens_hsa052220.52336674
82HIF-1 signaling pathway_Homo sapiens_hsa040660.52110428
83Lysine degradation_Homo sapiens_hsa003100.52068358
84Olfactory transduction_Homo sapiens_hsa047400.50122446
85Focal adhesion_Homo sapiens_hsa045100.49781376
86Taste transduction_Homo sapiens_hsa047420.49450303
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48862702
88Pertussis_Homo sapiens_hsa051330.48565651
89Thyroid cancer_Homo sapiens_hsa052160.48181631
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48106862
91GABAergic synapse_Homo sapiens_hsa047270.48046400
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47691805
93FoxO signaling pathway_Homo sapiens_hsa040680.46574070
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46210198
95AMPK signaling pathway_Homo sapiens_hsa041520.45864642
96GnRH signaling pathway_Homo sapiens_hsa049120.45793664
97Dorso-ventral axis formation_Homo sapiens_hsa043200.44461267
98ErbB signaling pathway_Homo sapiens_hsa040120.42409390
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42404354
100Legionellosis_Homo sapiens_hsa051340.42385481
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42069307
102Glutamatergic synapse_Homo sapiens_hsa047240.42067814
103Cholinergic synapse_Homo sapiens_hsa047250.39351724
104Apoptosis_Homo sapiens_hsa042100.38642251
105Hepatitis C_Homo sapiens_hsa051600.37374442
106Circadian rhythm_Homo sapiens_hsa047100.37168718
107MicroRNAs in cancer_Homo sapiens_hsa052060.36846386
108Acute myeloid leukemia_Homo sapiens_hsa052210.36130665
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36100393
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.35839302
111Renal cell carcinoma_Homo sapiens_hsa052110.35414997
112Long-term potentiation_Homo sapiens_hsa047200.35194380
113Glutathione metabolism_Homo sapiens_hsa004800.35089100
114Gap junction_Homo sapiens_hsa045400.34358255
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34121902
116Tight junction_Homo sapiens_hsa045300.34091740
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33176849
118Endometrial cancer_Homo sapiens_hsa052130.32850822
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32380018
120Pancreatic secretion_Homo sapiens_hsa049720.31427176
121ECM-receptor interaction_Homo sapiens_hsa045120.30766233
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30594867
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29339783
124Osteoclast differentiation_Homo sapiens_hsa043800.28881155
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28132808
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27729745
127Hippo signaling pathway_Homo sapiens_hsa043900.26747405
128Axon guidance_Homo sapiens_hsa043600.26405601
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24947495
130Metabolic pathways_Homo sapiens_hsa011000.24569496
131Phenylalanine metabolism_Homo sapiens_hsa003600.23485689
132Estrogen signaling pathway_Homo sapiens_hsa049150.23408081
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21818795
134Platelet activation_Homo sapiens_hsa046110.20601645
135VEGF signaling pathway_Homo sapiens_hsa043700.19740890
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19168456
137MAPK signaling pathway_Homo sapiens_hsa040100.18775688
138Dopaminergic synapse_Homo sapiens_hsa047280.18719584
139Serotonergic synapse_Homo sapiens_hsa047260.18463929
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.17937724
141Bile secretion_Homo sapiens_hsa049760.17180605
142Amoebiasis_Homo sapiens_hsa051460.16175896
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.15989499
144Amphetamine addiction_Homo sapiens_hsa050310.15116491
145Linoleic acid metabolism_Homo sapiens_hsa005910.14511764
146Nicotine addiction_Homo sapiens_hsa050330.12817439
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11246607
148Ras signaling pathway_Homo sapiens_hsa040140.11094719

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