SBNO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.45245537
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.45245537
3antigen processing and presentation of endogenous antigen (GO:0019883)5.31768266
4negative regulation of cell killing (GO:0031342)4.60488263
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60488263
6positive regulation of gamma-delta T cell activation (GO:0046645)4.41117213
7NIK/NF-kappaB signaling (GO:0038061)4.30008470
8detection of other organism (GO:0098543)3.89232694
9JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.86632596
10regulation of interleukin-12 biosynthetic process (GO:0045075)3.78495648
11detection of bacterium (GO:0016045)3.77414127
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69316832
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.69316832
14modulation by symbiont of host immune response (GO:0052553)3.69316832
15positive regulation by symbiont of host defense response (GO:0052509)3.69316832
16modulation by symbiont of host defense response (GO:0052031)3.69316832
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69316832
18regulation of gamma-delta T cell differentiation (GO:0045586)3.68341336
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63122298
20regulation of gamma-delta T cell activation (GO:0046643)3.62270169
21lipopolysaccharide-mediated signaling pathway (GO:0031663)3.50078446
22response to muramyl dipeptide (GO:0032495)3.46370476
23* macrophage activation involved in immune response (GO:0002281)3.44787155
24regulation of interferon-beta biosynthetic process (GO:0045357)3.42044428
25detection of external biotic stimulus (GO:0098581)3.41529705
26regulation of dendritic cell antigen processing and presentation (GO:0002604)3.38963202
27detection of molecule of bacterial origin (GO:0032490)3.37799976
28regulation of T-helper 2 cell differentiation (GO:0045628)3.32092085
29growth hormone receptor signaling pathway (GO:0060396)3.31266094
30response to type I interferon (GO:0034340)3.23475715
31immunoglobulin mediated immune response (GO:0016064)3.21893631
32regulation of type I interferon-mediated signaling pathway (GO:0060338)3.18663947
33type I interferon signaling pathway (GO:0060337)3.17259638
34cellular response to type I interferon (GO:0071357)3.17259638
35positive regulation of p38MAPK cascade (GO:1900745)3.10474660
36positive regulation of antigen processing and presentation (GO:0002579)3.09412550
37negative regulation of cytokine production involved in immune response (GO:0002719)3.07471732
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.07469847
39regulation of integrin activation (GO:0033623)3.02668777
40interferon-gamma-mediated signaling pathway (GO:0060333)3.00957514
41apoptotic cell clearance (GO:0043277)3.00896342
42positive regulation of interferon-alpha production (GO:0032727)3.00156400
43response to laminar fluid shear stress (GO:0034616)2.99644600
44positive regulation of B cell differentiation (GO:0045579)2.99588911
45antigen processing and presentation via MHC class Ib (GO:0002475)2.98138757
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97904672
47positive thymic T cell selection (GO:0045059)2.97108870
48negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.97084867
49detection of biotic stimulus (GO:0009595)2.97023829
50positive regulation of natural killer cell differentiation (GO:0032825)2.96624285
51negative regulation of interleukin-12 production (GO:0032695)2.96505353
52regulation of T cell tolerance induction (GO:0002664)2.95641142
53cellular extravasation (GO:0045123)2.95352105
54response to peptidoglycan (GO:0032494)2.93899792
55regulation of interferon-alpha production (GO:0032647)2.87358874
56regulation of response to interferon-gamma (GO:0060330)2.86158170
57positive regulation of histone deacetylation (GO:0031065)2.85708477
58regulation of T-helper 1 cell differentiation (GO:0045625)2.85644897
59regulation of vitamin D biosynthetic process (GO:0060556)2.83161630
60T-helper 1 type immune response (GO:0042088)2.81236813
61hemidesmosome assembly (GO:0031581)2.81142249
62positive regulation of type 2 immune response (GO:0002830)2.79227006
63cellular response to growth hormone stimulus (GO:0071378)2.78822790
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77893376
65negative regulation of lymphocyte mediated immunity (GO:0002707)2.77282084
66regulation of antigen processing and presentation (GO:0002577)2.76772341
67regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.76614803
68myeloid dendritic cell differentiation (GO:0043011)2.76111682
69germinal center formation (GO:0002467)2.72528656
70negative regulation of leukocyte mediated immunity (GO:0002704)2.70541095
71regulation of tolerance induction (GO:0002643)2.69546876
72regulation of type 2 immune response (GO:0002828)2.69384140
73negative regulation of innate immune response (GO:0045824)2.68104996
74regulation of mast cell degranulation (GO:0043304)2.67528599
75regulation of B cell receptor signaling pathway (GO:0050855)2.67291927
76protein localization to endosome (GO:0036010)2.66844151
77leukocyte aggregation (GO:0070486)2.66318819
78negative regulation of granulocyte differentiation (GO:0030853)2.65826353
79regulation of leukocyte degranulation (GO:0043300)2.64495017
80negative regulation of T cell mediated immunity (GO:0002710)2.61759462
81leukocyte cell-cell adhesion (GO:0007159)2.60776471
82negative regulation of type 2 immune response (GO:0002829)2.60725628
83negative regulation of interleukin-6 production (GO:0032715)2.59167961
84negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.58356380
85cell adhesion mediated by integrin (GO:0033627)2.58149174
86low-density lipoprotein particle clearance (GO:0034383)2.56567206
87regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56410303
88neutrophil activation involved in immune response (GO:0002283)2.56407638
89regulation of cholesterol storage (GO:0010885)2.55393416
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.55227601
91negative regulation of erythrocyte differentiation (GO:0045647)2.54005340
92production of molecular mediator involved in inflammatory response (GO:0002532)2.53383924
93respiratory burst (GO:0045730)2.52671175
94myeloid dendritic cell activation (GO:0001773)2.51084736
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.50916191
96response to protozoan (GO:0001562)2.48430624
97regulation of B cell differentiation (GO:0045577)2.48270161
98tolerance induction (GO:0002507)2.47618441
99JAK-STAT cascade (GO:0007259)2.46961370
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45763395
101regulation of podosome assembly (GO:0071801)2.45007785
102thymic T cell selection (GO:0045061)2.44310877
103dendritic cell differentiation (GO:0097028)2.43720990
104positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43326632
105modulation by symbiont of host cellular process (GO:0044068)2.42953702
106establishment of endothelial barrier (GO:0061028)2.42768590
107B cell mediated immunity (GO:0019724)2.41967830
108positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.41066635
109positive regulation of cellular amide metabolic process (GO:0034250)2.40779681
110* myeloid cell activation involved in immune response (GO:0002275)2.40456324
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39583264
112response to host immune response (GO:0052572)2.39583264
113negative thymic T cell selection (GO:0045060)2.38882249
114defense response to protozoan (GO:0042832)2.38757482
115mannose metabolic process (GO:0006013)2.38084387
116response to host (GO:0075136)2.37889466
117response to host defenses (GO:0052200)2.37889466
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37889466
119response to interferon-alpha (GO:0035455)2.35705385
120positive regulation of interferon-beta production (GO:0032728)2.35608785
121endothelial tube morphogenesis (GO:0061154)2.35042450
122morphogenesis of an endothelium (GO:0003159)2.35042450
123regulation of necroptotic process (GO:0060544)2.34675229
124negative regulation of stress fiber assembly (GO:0051497)2.32611528
125endothelial cell chemotaxis (GO:0035767)2.32522886
126neutrophil activation (GO:0042119)2.31155749
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29917933
128negative regulation of toll-like receptor signaling pathway (GO:0034122)2.29899606
129negative regulation of interleukin-8 production (GO:0032717)2.29868852
130pinocytosis (GO:0006907)2.29497126
131Arp2/3 complex-mediated actin nucleation (GO:0034314)2.29406861
132response to interleukin-15 (GO:0070672)2.28795757
133natural killer cell differentiation (GO:0001779)2.28594794
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28324236
135cellular response to interferon-gamma (GO:0071346)2.28178310
136mature B cell differentiation (GO:0002335)2.26891030
137regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.26510901
138granulocyte activation (GO:0036230)2.25398901
139regulation of p38MAPK cascade (GO:1900744)2.24951497
140hepatocyte apoptotic process (GO:0097284)2.23356779
141tyrosine phosphorylation of STAT protein (GO:0007260)2.22413496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.18048268
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.80612423
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.76927057
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.65380203
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.51109425
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22450905
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99040265
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.84750589
9MYC_22102868_ChIP-Seq_BL_Human2.68099096
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50896258
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.50646146
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42196331
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.41456506
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40629595
15VDR_21846776_ChIP-Seq_THP-1_Human2.39927102
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35714802
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.34962747
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32534017
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.18009991
20* TCF7_22412390_ChIP-Seq_EML_Mouse2.13392994
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11528988
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09528146
23MAF_26560356_Chip-Seq_TH1_Human2.08433852
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08030724
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04391268
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99920321
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94390499
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84349963
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83917501
30VDR_24763502_ChIP-Seq_THP-1_Human1.80748155
31CLOCK_20551151_ChIP-Seq_293T_Human1.78042735
32SCL_19346495_ChIP-Seq_HPC-7_Human1.77079073
33KDM2B_26808549_Chip-Seq_DND41_Human1.76059874
34RUNX_20019798_ChIP-Seq_JUKART_Human1.73521157
35MYB_26560356_Chip-Seq_TH2_Human1.72806091
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70667766
37UTX_26944678_Chip-Seq_JUKART_Human1.70064253
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67882810
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67800560
40MYB_26560356_Chip-Seq_TH1_Human1.65177204
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64297165
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60881888
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.59089217
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58797264
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57765357
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56992235
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55628320
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52710069
49SPI1_23127762_ChIP-Seq_K562_Human1.51935317
50KDM2B_26808549_Chip-Seq_K562_Human1.48739241
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47524691
52E2F7_22180533_ChIP-Seq_HELA_Human1.44627821
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43814691
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42215300
55SPI1_23547873_ChIP-Seq_NB4_Human1.39753597
56RACK7_27058665_Chip-Seq_MCF-7_Human1.32527142
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.31856354
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.31405443
59LXR_22292898_ChIP-Seq_THP-1_Human1.30655466
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29311993
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29222261
62* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28473977
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26563025
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.26135662
65MAF_26560356_Chip-Seq_TH2_Human1.25431293
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.24362931
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23070371
68* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22902476
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.22763784
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.21908681
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21443186
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21165733
73NCOR1_26117541_ChIP-Seq_K562_Human1.20554181
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20506418
75* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19333310
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.19057239
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18217774
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18047992
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18047992
80* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17734969
81ATF3_27146783_Chip-Seq_COLON_Human1.17062510
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16491087
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16478400
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15319989
85BCOR_27268052_Chip-Seq_Bcells_Human1.14512406
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14279262
87* P68_20966046_ChIP-Seq_HELA_Human1.13734442
88* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12709831
89* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10506641
90SMC4_20622854_ChIP-Seq_HELA_Human1.09795169
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09605561
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.09406731
93* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07900498
94BCL6_27268052_Chip-Seq_Bcells_Human1.07211994
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06579397
96* PU_27001747_Chip-Seq_BMDM_Mouse1.06550854
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.06395627
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06372108
99GATA1_22025678_ChIP-Seq_K562_Human1.05855540
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05565382
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03744142
102* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01636282
103GATA1_19941826_ChIP-Seq_K562_Human1.01570896
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.01441227
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01171023
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01011860
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00409753
108* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00243544
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.00091404
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98902186
111GATA3_27048872_Chip-Seq_THYMUS_Human0.98730249
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98487631
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98068349
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97707457
115FOXM1_23109430_ChIP-Seq_U2OS_Human0.97664540
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96775967
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96597077
118* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96039093
119CREB1_26743006_Chip-Seq_LNCaP_Human0.94203113
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93751584
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.92679843
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92395200
123* RXR_22158963_ChIP-Seq_LIVER_Mouse0.90658409
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88973653
125VDR_24787735_ChIP-Seq_THP-1_Human0.88598482
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88540228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.10351378
2MP0003300_gastrointestinal_ulcer2.85786537
3MP0001835_abnormal_antigen_presentation2.79118047
4MP0003705_abnormal_hypodermis_morpholog2.66536760
5MP0009278_abnormal_bone_marrow2.63743532
6MP0003436_decreased_susceptibility_to2.63428209
7MP0000685_abnormal_immune_system2.56452913
8MP0004510_myositis2.53247548
9MP0005451_abnormal_body_composition2.39613088
10MP0005387_immune_system_phenotype2.38567057
11MP0001790_abnormal_immune_system2.38567057
12MP0010352_gastrointestinal_tract_polyps2.38022739
13MP0002254_reproductive_system_inflammat2.31419434
14MP0003566_abnormal_cell_adhesion2.17801163
15MP0003724_increased_susceptibility_to2.14516595
16MP0001800_abnormal_humoral_immune2.08698678
17MP0004947_skin_inflammation2.05545369
18MP0009785_altered_susceptibility_to2.00862007
19MP0008438_abnormal_cutaneous_collagen1.98423160
20MP0002166_altered_tumor_susceptibility1.97944263
21MP0005000_abnormal_immune_tolerance1.95147008
22MP0002452_abnormal_antigen_presenting1.94217753
23MP0002419_abnormal_innate_immunity1.93330798
24MP0005025_abnormal_response_to1.90217304
25MP0005076_abnormal_cell_differentiation1.84922237
26MP0008260_abnormal_autophagy1.82028256
27MP0005023_abnormal_wound_healing1.77325089
28MP0002723_abnormal_immune_serum1.77175908
29MP0004808_abnormal_hematopoietic_stem1.73147762
30MP0001545_abnormal_hematopoietic_system1.69938371
31MP0005397_hematopoietic_system_phenotyp1.69938371
32MP0002405_respiratory_system_inflammati1.67192131
33MP0001819_abnormal_immune_cell1.65978037
34MP0002420_abnormal_adaptive_immunity1.65921011
35MP0001873_stomach_inflammation1.65552844
36MP0010155_abnormal_intestine_physiology1.64968301
37MP0001533_abnormal_skeleton_physiology1.64416863
38MP0002396_abnormal_hematopoietic_system1.62091776
39MP0001853_heart_inflammation1.60749015
40MP0003191_abnormal_cellular_cholesterol1.57953238
41MP0006082_CNS_inflammation1.56061369
42MP0002006_tumorigenesis1.54059483
43MP0002148_abnormal_hypersensitivity_rea1.53587321
44MP0003448_altered_tumor_morphology1.52995258
45MP0005464_abnormal_platelet_physiology1.52292008
46MP0009840_abnormal_foam_cell1.50790420
47MP0005671_abnormal_response_to1.50193615
48MP0003091_abnormal_cell_migration1.46266264
49MP0002398_abnormal_bone_marrow1.44728150
50MP0003453_abnormal_keratinocyte_physiol1.42730248
51MP0003763_abnormal_thymus_physiology1.41899744
52MP0002877_abnormal_melanocyte_morpholog1.41362825
53MP0010307_abnormal_tumor_latency1.40840623
54MP0005275_abnormal_skin_tensile1.37701073
55MP0000716_abnormal_immune_system1.35903441
56MP0001845_abnormal_inflammatory_respons1.34765186
57MP0004858_abnormal_nervous_system1.34584840
58MP0002933_joint_inflammation1.30217188
59MP0001851_eye_inflammation1.29552413
60MP0003045_fibrosis1.28066276
61MP0008004_abnormal_stomach_pH1.26527023
62MP0000689_abnormal_spleen_morphology1.25404239
63MP0005058_abnormal_lysosome_morphology1.25028398
64MP0002722_abnormal_immune_system1.22801765
65MP0003279_aneurysm1.21064935
66MP0002138_abnormal_hepatobiliary_system1.18431375
67MP0000569_abnormal_digit_pigmentation1.17810165
68MP0002429_abnormal_blood_cell1.17236007
69MP0000858_altered_metastatic_potential1.16791077
70MP0009333_abnormal_splenocyte_physiolog1.15977095
71MP0001958_emphysema1.14306158
72MP0000465_gastrointestinal_hemorrhage1.13982701
73MP0000343_altered_response_to1.13504583
74MP0002060_abnormal_skin_morphology1.12853920
75MP0002998_abnormal_bone_remodeling1.12019421
76MP0005166_decreased_susceptibility_to1.11476730
77MP0004381_abnormal_hair_follicle1.10858744
78MP0000733_abnormal_muscle_development1.10305294
79MP0005164_abnormal_response_to1.08382084
80MP0005310_abnormal_salivary_gland1.06409413
81MP0008469_abnormal_protein_level1.03968693
82MP0003828_pulmonary_edema1.02337474
83MP0003172_abnormal_lysosome_physiology1.02141022
84MP0003866_abnormal_defecation1.00387140
85MP0000767_abnormal_smooth_muscle1.00249100
86MP0001849_ear_inflammation0.99688364
87MP0005390_skeleton_phenotype0.96772100
88MP0010234_abnormal_vibrissa_follicle0.94207313
89MP0003183_abnormal_peptide_metabolism0.93834100
90MP0000703_abnormal_thymus_morphology0.93246795
91MP0006054_spinal_hemorrhage0.93082904
92MP0008961_abnormal_basal_metabolism0.90859073
93MP0004883_abnormal_blood_vessel0.90585093
94MP0001243_abnormal_dermal_layer0.88534052
95MP0003075_altered_response_to0.86805679
96MP0002332_abnormal_exercise_endurance0.86693102
97MP0003690_abnormal_glial_cell0.85863040
98MP0000490_abnormal_crypts_of0.85860533
99MP0009764_decreased_sensitivity_to0.85178199
100MP0002796_impaired_skin_barrier0.84979479
101MP0001216_abnormal_epidermal_layer0.84472307
102MP0005409_darkened_coat_color0.83581860
103MP0001663_abnormal_digestive_system0.83291140
104MP0010368_abnormal_lymphatic_system0.80670453
105MP0000249_abnormal_blood_vessel0.80253288
106MP0005666_abnormal_adipose_tissue0.77430974
107MP0005257_abnormal_intraocular_pressure0.76998660
108MP0000678_abnormal_parathyroid_gland0.75844713
109MP0000609_abnormal_liver_physiology0.75640688
110MP0004185_abnormal_adipocyte_glucose0.73257235
111MP0001915_intracranial_hemorrhage0.72913593
112MP0001348_abnormal_lacrimal_gland0.72582916
113MP0009931_abnormal_skin_appearance0.71526818
114MP0002132_abnormal_respiratory_system0.70739676
115MP0000604_amyloidosis0.70632077
116MP0009763_increased_sensitivity_to0.70572381
117MP0003795_abnormal_bone_structure0.70185921

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.50789612
2Recurrent abscess formation (HP:0002722)3.30325306
3Elevated erythrocyte sedimentation rate (HP:0003565)3.29922303
4Myositis (HP:0100614)3.24838584
5Recurrent fungal infections (HP:0002841)3.18878432
6Abnormality of glycolipid metabolism (HP:0010969)3.15843072
7Abnormality of liposaccharide metabolism (HP:0010968)3.15843072
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.15843072
9Cerebral aneurysm (HP:0004944)3.15350204
10Myocardial infarction (HP:0001658)3.12931990
11Peritonitis (HP:0002586)3.05315003
12Interstitial pulmonary disease (HP:0006530)3.03730826
13Increased IgE level (HP:0003212)3.03694570
14Stomatitis (HP:0010280)3.03550082
15Recurrent bacterial skin infections (HP:0005406)3.01505562
16Cellulitis (HP:0100658)2.94772138
17Abnormality of the nasal mucosa (HP:0000433)2.94603738
18Chronic otitis media (HP:0000389)2.92009387
19Orchitis (HP:0100796)2.90030677
20Nasal polyposis (HP:0100582)2.89874578
21Keratoconjunctivitis sicca (HP:0001097)2.87752664
22Loss of speech (HP:0002371)2.81495295
23Hematochezia (HP:0002573)2.81176924
24Osteolytic defects of the hand bones (HP:0009699)2.80343329
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.80343329
26Autoimmune thrombocytopenia (HP:0001973)2.75915292
27Recurrent viral infections (HP:0004429)2.71473646
28Chronic obstructive pulmonary disease (HP:0006510)2.65062242
29Obstructive lung disease (HP:0006536)2.65062242
30Protrusio acetabuli (HP:0003179)2.61954586
31Colitis (HP:0002583)2.60540409
32Pustule (HP:0200039)2.58500066
33Thin bony cortex (HP:0002753)2.58297908
34Premature rupture of membranes (HP:0001788)2.55053912
35Keratoconjunctivitis (HP:0001096)2.54410577
36Spontaneous hematomas (HP:0007420)2.53740072
37Mediastinal lymphadenopathy (HP:0100721)2.52586129
38Recurrent gram-negative bacterial infections (HP:0005420)2.44152888
39Gingivitis (HP:0000230)2.42254349
40Aortic aneurysm (HP:0004942)2.41696427
41Increased connective tissue (HP:0009025)2.40009958
42Malnutrition (HP:0004395)2.39567722
43Inflammation of the large intestine (HP:0002037)2.37767755
44Periodontitis (HP:0000704)2.37288920
45Increased density of long bones (HP:0006392)2.37217389
46Emphysema (HP:0002097)2.37099024
47Persistence of primary teeth (HP:0006335)2.36647898
48Abnormality of macrophages (HP:0004311)2.36626848
49Recurrent bronchitis (HP:0002837)2.36359606
50Thick nail (HP:0001805)2.33667163
51Broad face (HP:0000283)2.32739398
52Gastrointestinal inflammation (HP:0004386)2.32623934
53Atrophic scars (HP:0001075)2.31896277
54Segmental peripheral demyelination/remyelination (HP:0003481)2.30962734
55Amyloidosis (HP:0011034)2.29300667
56Thrombocytosis (HP:0001894)2.29162252
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28693667
58Abnormality of polysaccharide metabolism (HP:0011012)2.28693667
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28693667
60Systemic lupus erythematosus (HP:0002725)2.28162362
61Recurrent cutaneous fungal infections (HP:0011370)2.27366182
62Chronic mucocutaneous candidiasis (HP:0002728)2.27366182
63Arterial thrombosis (HP:0004420)2.26314627
64Recurrent skin infections (HP:0001581)2.26115059
65Cervical subluxation (HP:0003308)2.22399463
66Urticaria (HP:0001025)2.22095185
67Mucopolysacchariduria (HP:0008155)2.22011569
68Urinary glycosaminoglycan excretion (HP:0003541)2.22011569
69Milia (HP:0001056)2.21885495
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.21372196
71Obstructive sleep apnea (HP:0002870)2.18634581
72Vasculitis (HP:0002633)2.17818029
73Vertebral compression fractures (HP:0002953)2.15786100
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.15175466
75Encephalitis (HP:0002383)2.14164117
76Abnormality of the fingertips (HP:0001211)2.13256567
77Dilatation of the ascending aorta (HP:0005111)2.12084474
78Increased serum ferritin (HP:0003281)2.11735083
79Shallow orbits (HP:0000586)2.10944820
80Mitral valve prolapse (HP:0001634)2.07428181
81Esophageal varix (HP:0002040)2.06201329
82Ankle contracture (HP:0006466)2.06188062
83Gingival bleeding (HP:0000225)2.03478708
84Aortic dissection (HP:0002647)2.02916263
85Distal lower limb amyotrophy (HP:0008944)2.01752875
86Ulnar bowing (HP:0003031)2.00923697
87Abnormal platelet volume (HP:0011876)2.00445988
88Increased cerebral lipofuscin (HP:0011813)2.00095083
89Retrobulbar optic neuritis (HP:0100654)1.99104196
90Optic neuritis (HP:0100653)1.99104196
91Premature loss of primary teeth (HP:0006323)1.98797070
92Leukocytosis (HP:0001974)1.97916804
93Aneurysm (HP:0002617)1.97013363
94Polycythemia (HP:0001901)1.95895860
95Pulmonary infiltrates (HP:0002113)1.95776092
96Hemorrhage of the eye (HP:0011885)1.93711791
97Skin ulcer (HP:0200042)1.93393637
98Distal upper limb amyotrophy (HP:0007149)1.92875397
99Upper limb amyotrophy (HP:0009129)1.92875397
100Osteomyelitis (HP:0002754)1.91411554
101Gastrointestinal stroma tumor (HP:0100723)1.91307718
102Epistaxis (HP:0000421)1.91282463
103Abnormal platelet function (HP:0011869)1.91111871
104Impaired platelet aggregation (HP:0003540)1.91111871
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90480570
106Increased IgM level (HP:0003496)1.89884220
107Purpura (HP:0000979)1.88223285
108Nuclear cataract (HP:0100018)1.87999142
109Slow saccadic eye movements (HP:0000514)1.87300405
110Prolonged bleeding time (HP:0003010)1.87208965
111Increased mean platelet volume (HP:0011877)1.87021555
112Fatigue (HP:0012378)1.86395055
113Polygenic inheritance (HP:0010982)1.86106866
114IgM deficiency (HP:0002850)1.85463169
115Gangrene (HP:0100758)1.83886003
116Abnormality of the peritoneum (HP:0002585)1.82415926
117Chest pain (HP:0100749)1.82010710
118Eosinophilia (HP:0001880)1.82000760
119Episodic fever (HP:0001954)1.81726310
120Pulmonary embolism (HP:0002204)1.79729522
121Hemoptysis (HP:0002105)1.79666748
122Vacuolated lymphocytes (HP:0001922)1.79227567
123Broad metatarsal (HP:0001783)1.78116235
124T lymphocytopenia (HP:0005403)1.78110574
125Anorexia (HP:0002039)1.77822076
126Spondylolisthesis (HP:0003302)1.77401191
127Alopecia of scalp (HP:0002293)1.77396473
128Radial bowing (HP:0002986)1.76964492
129Abnormality of the pericardium (HP:0001697)1.76643977
130Hepatosplenomegaly (HP:0001433)1.76499602
131Syringomyelia (HP:0003396)1.75898168
132Spinal cord lesions (HP:0100561)1.75898168
133Neurofibrillary tangles (HP:0002185)1.75540524
134Acne (HP:0001061)1.75211087
135Tetraparesis (HP:0002273)1.72841127
136Meningitis (HP:0001287)1.70010995
137IgA deficiency (HP:0002720)1.69457353
138Gastrointestinal infarctions (HP:0005244)1.68130246
139Dysostosis multiplex (HP:0000943)1.66212758
140Hypergammaglobulinemia (HP:0010702)1.66087689
141Axonal loss (HP:0003447)1.65079436
142Hand muscle atrophy (HP:0009130)1.64761717
143Panhypogammaglobulinemia (HP:0003139)1.64589987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.66125531
2MAP4K13.09303654
3EPHB13.02223911
4TRIB33.01181706
5PRPF4B2.94124803
6FGFR42.78497713
7TYK22.74770053
8EPHA32.55345575
9JAK32.36329137
10MAP3K142.26877068
11TBK12.21274536
12EEF2K2.15630825
13PKN22.08801908
14MAP3K102.03386115
15RIPK11.95022304
16JAK11.94961201
17TTN1.92871408
18CDK121.92523999
19SMG11.89827884
20TGFBR21.78936268
21STK101.77080432
22KIT1.72864783
23TAOK21.71361147
24PTK61.67945593
25IKBKE1.58780849
26IKBKB1.55662814
27CDC42BPA1.54775630
28FGFR31.50217797
29ZAP701.47047325
30MAP2K31.42936425
31LRRK21.39217444
32RPS6KA41.38587751
33TNK21.37933552
34ICK1.36384612
35BLK1.34894998
36SIK11.34679221
37MAP3K31.34525452
38CHUK1.32916725
39GRK61.31029749
40CSK1.27141284
41NME21.22941938
42SIK31.22448267
43IRAK31.21250716
44FGR1.19203920
45BMX1.16638992
46MARK21.15859396
47CSF1R1.15314605
48HCK1.13778256
49MAP3K61.11839649
50PRKD21.11436231
51EPHA21.10371387
52MAP3K131.10157283
53NLK1.09759309
54BTK1.07506406
55JAK21.05052504
56DDR21.04302540
57PAK41.04095345
58KDR1.01483966
59PIM11.00276443
60PIM21.00101587
61CAMK1D0.99579755
62IRAK20.99563312
63IRAK40.97141145
64TAOK30.91965891
65TGFBR10.91522778
66FLT30.91045406
67ITK0.83419656
68SIK20.83177893
69TRPM70.82719922
70ALK0.81687259
71LCK0.81190443
72KSR20.80511459
73PDPK10.76008072
74GRK70.73611219
75MTOR0.73357014
76SYK0.71444520
77TXK0.70500096
78RPS6KC10.70457397
79RPS6KL10.70457397
80CDK60.70212684
81PTK20.69732931
82PDGFRA0.66854554
83TAOK10.65068144
84MAP3K110.64522325
85RPS6KA20.64493133
86MAPK70.63044986
87MATK0.62739864
88RPS6KB20.61503895
89MARK30.60817431
90MOS0.60660911
91MAP3K70.60660319
92PDK10.59994605
93PAK20.59960736
94TEC0.59311069
95MAPKAPK30.56966062
96MAPKAPK20.55343211
97MAP3K80.54124749
98PDGFRB0.53012685
99HIPK20.52003204
100CAMK1G0.51431427
101RIPK40.50656616
102NEK90.50298269
103MAP2K60.49985778
104EGFR0.49444676
105TESK20.48863466
106DMPK0.47228795
107STK30.46411585
108IRAK10.45826469
109MAP3K10.45700673
110STK380.44798251
111TESK10.44459207
112MAPK120.44199276
113CDK40.43145132
114GSK3A0.42279917
115RPS6KA60.41762736
116CLK10.41010209
117PRKG20.40581644
118TIE10.40468524
119FES0.40229520
120SCYL20.39746049
121ABL10.39403681
122RET0.38491812
123NEK20.37420733
124LYN0.36786699
125TYRO30.36697009
126FYN0.36613113
127MAPK110.36585370
128PRKAA20.35714460
129MST1R0.33164030
130RPS6KA10.32827839
131INSR0.31664546

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.63757169
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.40659967
3Osteoclast differentiation_Homo sapiens_hsa043802.38832081
4Toxoplasmosis_Homo sapiens_hsa051452.06549468
5B cell receptor signaling pathway_Homo sapiens_hsa046621.99740872
6Malaria_Homo sapiens_hsa051441.98229063
7Staphylococcus aureus infection_Homo sapiens_hsa051501.96607901
8TNF signaling pathway_Homo sapiens_hsa046681.91254806
9Measles_Homo sapiens_hsa051621.88431805
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80731541
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76825046
12Antigen processing and presentation_Homo sapiens_hsa046121.72341231
13Acute myeloid leukemia_Homo sapiens_hsa052211.68404813
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.66261321
15Primary immunodeficiency_Homo sapiens_hsa053401.61555483
16Apoptosis_Homo sapiens_hsa042101.61416040
17Chronic myeloid leukemia_Homo sapiens_hsa052201.60837565
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.60624578
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59708606
20Pertussis_Homo sapiens_hsa051331.58567510
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56557408
22Small cell lung cancer_Homo sapiens_hsa052221.55476616
23Influenza A_Homo sapiens_hsa051641.55129487
24Autoimmune thyroid disease_Homo sapiens_hsa053201.52887178
25Legionellosis_Homo sapiens_hsa051341.52615468
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48477234
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47388985
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.45979712
29Shigellosis_Homo sapiens_hsa051311.43543300
30Tuberculosis_Homo sapiens_hsa051521.41041741
31Caffeine metabolism_Homo sapiens_hsa002321.40299366
32Herpes simplex infection_Homo sapiens_hsa051681.40255100
33Hematopoietic cell lineage_Homo sapiens_hsa046401.37394643
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32263266
35Hepatitis B_Homo sapiens_hsa051611.29975919
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28669916
37Pancreatic cancer_Homo sapiens_hsa052121.25088107
38Amoebiasis_Homo sapiens_hsa051461.23369553
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.23310984
40Hepatitis C_Homo sapiens_hsa051601.19994756
41T cell receptor signaling pathway_Homo sapiens_hsa046601.18447194
42Viral myocarditis_Homo sapiens_hsa054161.14415662
43Salmonella infection_Homo sapiens_hsa051321.11079624
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10017404
45Chemokine signaling pathway_Homo sapiens_hsa040621.09886591
46Type I diabetes mellitus_Homo sapiens_hsa049401.09773098
47Proteoglycans in cancer_Homo sapiens_hsa052051.07807607
48Focal adhesion_Homo sapiens_hsa045101.07730469
49Prolactin signaling pathway_Homo sapiens_hsa049171.07427751
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.05295521
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04385140
52ECM-receptor interaction_Homo sapiens_hsa045121.03936036
53Insulin resistance_Homo sapiens_hsa049311.03625981
54Platelet activation_Homo sapiens_hsa046111.01786894
55Notch signaling pathway_Homo sapiens_hsa043300.98984228
56MicroRNAs in cancer_Homo sapiens_hsa052060.95336151
57HTLV-I infection_Homo sapiens_hsa051660.95228854
58Viral carcinogenesis_Homo sapiens_hsa052030.93349636
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93290200
60Other glycan degradation_Homo sapiens_hsa005110.93252125
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92478543
62Lysosome_Homo sapiens_hsa041420.92422814
63Prion diseases_Homo sapiens_hsa050200.92384703
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92053909
65Adherens junction_Homo sapiens_hsa045200.90090831
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89856897
67African trypanosomiasis_Homo sapiens_hsa051430.88787830
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.88523818
69Allograft rejection_Homo sapiens_hsa053300.86789450
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86390491
71HIF-1 signaling pathway_Homo sapiens_hsa040660.86068111
72Graft-versus-host disease_Homo sapiens_hsa053320.83508505
73VEGF signaling pathway_Homo sapiens_hsa043700.82815847
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79970074
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.77422666
76Epstein-Barr virus infection_Homo sapiens_hsa051690.76899768
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76558054
78Complement and coagulation cascades_Homo sapiens_hsa046100.76025804
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74046364
80Bladder cancer_Homo sapiens_hsa052190.72446552
81GnRH signaling pathway_Homo sapiens_hsa049120.70150232
82Non-small cell lung cancer_Homo sapiens_hsa052230.69428110
83mTOR signaling pathway_Homo sapiens_hsa041500.64455614
84Asthma_Homo sapiens_hsa053100.63634212
85p53 signaling pathway_Homo sapiens_hsa041150.61616051
86Lysine degradation_Homo sapiens_hsa003100.61322699
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.60973247
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58465726
89ErbB signaling pathway_Homo sapiens_hsa040120.58321905
90Pathways in cancer_Homo sapiens_hsa052000.58286531
91Choline metabolism in cancer_Homo sapiens_hsa052310.58073218
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57964448
93Insulin signaling pathway_Homo sapiens_hsa049100.55927939
94FoxO signaling pathway_Homo sapiens_hsa040680.55709401
95Colorectal cancer_Homo sapiens_hsa052100.54767957
96Fructose and mannose metabolism_Homo sapiens_hsa000510.53266180
97Phagosome_Homo sapiens_hsa041450.52923736
98Prostate cancer_Homo sapiens_hsa052150.51840440
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49546423
100Renal cell carcinoma_Homo sapiens_hsa052110.49487629
101Dorso-ventral axis formation_Homo sapiens_hsa043200.49417103
102Glioma_Homo sapiens_hsa052140.48831865
103Endocytosis_Homo sapiens_hsa041440.48650935
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48349260
105Galactose metabolism_Homo sapiens_hsa000520.48190674
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46318491
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46206569
108Rheumatoid arthritis_Homo sapiens_hsa053230.45131111
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44196846
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43995566
111Estrogen signaling pathway_Homo sapiens_hsa049150.42790265
112Endometrial cancer_Homo sapiens_hsa052130.41921927
113MAPK signaling pathway_Homo sapiens_hsa040100.41832807
114Rap1 signaling pathway_Homo sapiens_hsa040150.40013154
115ABC transporters_Homo sapiens_hsa020100.39645893
116Type II diabetes mellitus_Homo sapiens_hsa049300.38110788
117Renin-angiotensin system_Homo sapiens_hsa046140.34616085
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.32514650

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