SC5D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.36522738
2L-phenylalanine catabolic process (GO:0006559)7.36522738
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.85906651
4L-phenylalanine metabolic process (GO:0006558)6.85906651
5aromatic amino acid family catabolic process (GO:0009074)6.42390739
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.74328138
7bile acid biosynthetic process (GO:0006699)5.74095785
8alpha-linolenic acid metabolic process (GO:0036109)5.62711176
9tryptophan catabolic process (GO:0006569)5.59598129
10indole-containing compound catabolic process (GO:0042436)5.59598129
11indolalkylamine catabolic process (GO:0046218)5.59598129
12glyoxylate metabolic process (GO:0046487)5.37931012
13kynurenine metabolic process (GO:0070189)5.35949052
14tryptophan metabolic process (GO:0006568)5.23285976
15high-density lipoprotein particle remodeling (GO:0034375)5.12339327
16negative regulation of fibrinolysis (GO:0051918)5.03879317
17peptidyl-glutamic acid carboxylation (GO:0017187)5.03129201
18protein carboxylation (GO:0018214)5.03129201
19urea metabolic process (GO:0019627)5.01734604
20urea cycle (GO:0000050)5.01734604
21cysteine metabolic process (GO:0006534)4.96445336
22sulfur amino acid catabolic process (GO:0000098)4.94547449
23bile acid metabolic process (GO:0008206)4.91635924
24complement activation, alternative pathway (GO:0006957)4.90504535
25regulation of fibrinolysis (GO:0051917)4.86118336
26regulation of protein activation cascade (GO:2000257)4.76965849
27nitrogen cycle metabolic process (GO:0071941)4.61057964
28aromatic amino acid family metabolic process (GO:0009072)4.58099115
29tyrosine metabolic process (GO:0006570)4.56732100
30regulation of cholesterol esterification (GO:0010872)4.56498443
31coenzyme catabolic process (GO:0009109)4.50114294
32regulation of triglyceride catabolic process (GO:0010896)4.45794807
33reverse cholesterol transport (GO:0043691)4.45717219
34regulation of complement activation (GO:0030449)4.44816443
35macromolecular complex remodeling (GO:0034367)4.40229726
36plasma lipoprotein particle remodeling (GO:0034369)4.40229726
37protein-lipid complex remodeling (GO:0034368)4.40229726
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.37801381
39serine family amino acid catabolic process (GO:0009071)4.35951570
40cellular glucuronidation (GO:0052695)4.33523244
41plasma lipoprotein particle clearance (GO:0034381)4.33317024
42homocysteine metabolic process (GO:0050667)4.33177591
43fatty acid elongation (GO:0030497)4.31259962
44triglyceride homeostasis (GO:0070328)4.29263271
45acylglycerol homeostasis (GO:0055090)4.29263271
46alpha-amino acid catabolic process (GO:1901606)4.26236263
47cellular ketone body metabolic process (GO:0046950)4.15869724
48* sterol biosynthetic process (GO:0016126)4.15272891
49phospholipid efflux (GO:0033700)4.12917968
50bile acid and bile salt transport (GO:0015721)4.12372283
51cholesterol efflux (GO:0033344)4.12317858
52cellular biogenic amine catabolic process (GO:0042402)4.08838499
53amine catabolic process (GO:0009310)4.08838499
54negative regulation of cholesterol transport (GO:0032375)4.06778130
55negative regulation of sterol transport (GO:0032372)4.06778130
56amino-acid betaine metabolic process (GO:0006577)4.06043269
57ethanol oxidation (GO:0006069)4.05010579
58aldehyde catabolic process (GO:0046185)4.03315294
59acetyl-CoA metabolic process (GO:0006084)4.00431331
60cofactor catabolic process (GO:0051187)3.99986010
61indolalkylamine metabolic process (GO:0006586)3.97429496
62cellular amino acid catabolic process (GO:0009063)3.94045417
63uronic acid metabolic process (GO:0006063)3.93618033
64glucuronate metabolic process (GO:0019585)3.93618033
65glutamate metabolic process (GO:0006536)3.92311131
66very long-chain fatty acid metabolic process (GO:0000038)3.91837049
67lysine catabolic process (GO:0006554)3.88696285
68lysine metabolic process (GO:0006553)3.88696285
69very-low-density lipoprotein particle assembly (GO:0034379)3.85813541
70low-density lipoprotein particle remodeling (GO:0034374)3.85772468
71imidazole-containing compound metabolic process (GO:0052803)3.85035533
72serine family amino acid biosynthetic process (GO:0009070)3.81461557
73benzene-containing compound metabolic process (GO:0042537)3.79404637
74fibrinolysis (GO:0042730)3.78207770
75plasma lipoprotein particle assembly (GO:0034377)3.76022806
76serine family amino acid metabolic process (GO:0009069)3.75240636
77cellular modified amino acid catabolic process (GO:0042219)3.74275430
78* cholesterol biosynthetic process (GO:0006695)3.72285613
79glycine metabolic process (GO:0006544)3.66935199
80arginine metabolic process (GO:0006525)3.64504527
81cholesterol homeostasis (GO:0042632)3.63187727
82short-chain fatty acid metabolic process (GO:0046459)3.62835967
83ketone body metabolic process (GO:1902224)3.61146497
84positive regulation of triglyceride lipase activity (GO:0061365)3.59708984
85positive regulation of lipoprotein lipase activity (GO:0051006)3.59708984
86regulation of bile acid biosynthetic process (GO:0070857)3.59407521
87fatty-acyl-CoA biosynthetic process (GO:0046949)3.59292369
88drug catabolic process (GO:0042737)3.59166805
89regulation of cholesterol biosynthetic process (GO:0045540)3.57084262
90sterol homeostasis (GO:0055092)3.56866678
91regulation of cholesterol metabolic process (GO:0090181)3.55099443
92dicarboxylic acid biosynthetic process (GO:0043650)3.54758455
93L-serine metabolic process (GO:0006563)3.54300553
94opsonization (GO:0008228)3.49709951
95DNA double-strand break processing (GO:0000729)3.49388941
96heme transport (GO:0015886)3.49380979
97negative regulation of lipase activity (GO:0060192)3.49305097
98organic acid catabolic process (GO:0016054)3.49287464
99carboxylic acid catabolic process (GO:0046395)3.49287464
100positive regulation of lipid catabolic process (GO:0050996)3.48581975
101intestinal cholesterol absorption (GO:0030299)3.45244789
102phospholipid homeostasis (GO:0055091)3.42721940
103protein-lipid complex assembly (GO:0065005)3.42449116
104presynaptic membrane assembly (GO:0097105)3.27833264
105isoprenoid biosynthetic process (GO:0008299)3.21787881
106establishment of integrated proviral latency (GO:0075713)2.97802940
107chromatin remodeling at centromere (GO:0031055)2.94192413
108regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.93472605
109CENP-A containing nucleosome assembly (GO:0034080)2.82492407
110cullin deneddylation (GO:0010388)2.81548234
111water-soluble vitamin biosynthetic process (GO:0042364)2.79435204
112negative regulation of DNA-dependent DNA replication (GO:2000104)2.78995268
113anterior/posterior axis specification, embryo (GO:0008595)2.77487094
114presynaptic membrane organization (GO:0097090)2.74766898
115regulation of coenzyme metabolic process (GO:0051196)2.61143714
116regulation of cofactor metabolic process (GO:0051193)2.61143714
117protein neddylation (GO:0045116)2.58894725
118regulation of acyl-CoA biosynthetic process (GO:0050812)2.58744232
119branched-chain amino acid catabolic process (GO:0009083)2.57237672
120regulation of glucokinase activity (GO:0033131)2.57174767
121regulation of hexokinase activity (GO:1903299)2.57174767
122negative regulation of hormone biosynthetic process (GO:0032353)2.55497623
123regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.53965377
124proteasome assembly (GO:0043248)2.53476911
125histone exchange (GO:0043486)2.52514273
126protein deneddylation (GO:0000338)2.51935780
127response to nitrosative stress (GO:0051409)2.51786565
128negative regulation of DNA recombination (GO:0045910)2.49968486
129regulation of cardioblast differentiation (GO:0051890)2.47689100
130regulation of sulfur metabolic process (GO:0042762)2.45926057
131female gonad development (GO:0008585)2.44871073
132non-recombinational repair (GO:0000726)2.44331782
133double-strand break repair via nonhomologous end joining (GO:0006303)2.44331782
134bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42089521
135sequestering of extracellular ligand from receptor (GO:0035581)2.40887584
136regulation of centriole replication (GO:0046599)2.39678203
137DNA ligation (GO:0006266)2.39416287
138dorsal/ventral axis specification (GO:0009950)2.38701214
139paraxial mesoderm development (GO:0048339)2.38451901
140DNA damage response, detection of DNA damage (GO:0042769)2.36803629
141exogenous drug catabolic process (GO:0042738)2.35601318
142ribosome assembly (GO:0042255)2.35200737
143purine nucleobase biosynthetic process (GO:0009113)2.33444336
144L-methionine salvage (GO:0071267)2.32748647
145L-methionine biosynthetic process (GO:0071265)2.32748647
146amino acid salvage (GO:0043102)2.32748647
147DNA replication-independent nucleosome assembly (GO:0006336)2.31817964
148DNA replication-independent nucleosome organization (GO:0034724)2.31817964
149DNA replication-dependent nucleosome assembly (GO:0006335)2.29165465
150DNA replication-dependent nucleosome organization (GO:0034723)2.29165465
151spindle checkpoint (GO:0031577)2.28859053
152negative regulation of hormone metabolic process (GO:0032351)2.25497326
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.24465537
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.24465537
155negative regulation of mitotic sister chromatid segregation (GO:0033048)2.24465537
156negative regulation of mitotic sister chromatid separation (GO:2000816)2.24465537
157negative regulation of sister chromatid segregation (GO:0033046)2.24465537
158mitotic spindle checkpoint (GO:0071174)2.24313275
159regulation of helicase activity (GO:0051095)2.22856943
160protein localization to kinetochore (GO:0034501)2.22712425
161C4-dicarboxylate transport (GO:0015740)2.18949870
162omega-hydroxylase P450 pathway (GO:0097267)2.18468338
163gap junction assembly (GO:0016264)2.17682387
164* steroid biosynthetic process (GO:0006694)2.17521157
165regulation of mitotic spindle checkpoint (GO:1903504)2.16043956
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.16043956
167replication fork processing (GO:0031297)2.15607813
168negative regulation of chromosome segregation (GO:0051985)2.15433115
169anterior/posterior axis specification (GO:0009948)2.15351984
170lactate metabolic process (GO:0006089)2.11798432
171response to phenylpropanoid (GO:0080184)2.11520043
172vascular smooth muscle contraction (GO:0014829)2.11224571
173mitotic metaphase plate congression (GO:0007080)2.09851098
174regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.08653491
175regulation of mitotic metaphase/anaphase transition (GO:0030071)2.08653491
176metaphase plate congression (GO:0051310)2.08308583
177mitotic G2/M transition checkpoint (GO:0044818)2.08229179
178establishment of viral latency (GO:0019043)2.07458155
179IMP biosynthetic process (GO:0006188)2.07258777
180vitamin biosynthetic process (GO:0009110)2.06934082
181embryonic foregut morphogenesis (GO:0048617)2.06639142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.36946868
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.40835337
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.16952207
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.86926672
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.72061338
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.52752895
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.25072009
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.62906857
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.57909647
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.13058071
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63819137
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63207223
13FUS_26573619_Chip-Seq_HEK293_Human2.27019278
14IGF1R_20145208_ChIP-Seq_DFB_Human2.23673987
15EWS_26573619_Chip-Seq_HEK293_Human2.16353602
16ZNF274_21170338_ChIP-Seq_K562_Hela2.07177076
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05897313
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04663150
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4836742
20VDR_22108803_ChIP-Seq_LS180_Human1.97200169
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.96249306
22ELK1_19687146_ChIP-ChIP_HELA_Human1.90666072
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88964001
24AR_21909140_ChIP-Seq_LNCAP_Human1.86092080
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.84637043
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.81152362
27HTT_18923047_ChIP-ChIP_STHdh_Human1.80628826
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76625856
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67421873
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67110752
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66927931
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61721360
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60758914
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60370126
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60336729
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60244086
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.58658952
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58203750
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57411599
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.56951098
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53270505
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52157792
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51499848
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51298722
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49271210
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.47439217
47CLOCK_20551151_ChIP-Seq_293T_Human1.47362456
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44957503
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.43891455
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.39451804
51SMAD4_21799915_ChIP-Seq_A2780_Human1.38356599
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38082382
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34413804
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33048231
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32492550
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31775222
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31137748
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31137748
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28231667
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21894606
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.21488052
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20885821
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.20078035
64TAF15_26573619_Chip-Seq_HEK293_Human1.20064699
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19090607
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18794829
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18251270
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17363360
69TCF4_22108803_ChIP-Seq_LS180_Human1.16419977
70E2F7_22180533_ChIP-Seq_HELA_Human1.15846087
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15739469
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14187024
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.08880619
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08785248
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08443288
76STAT3_23295773_ChIP-Seq_U87_Human1.04899505
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01870292
78AR_25329375_ChIP-Seq_VCAP_Human1.01604919
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01600504
80CBP_20019798_ChIP-Seq_JUKART_Human1.01102477
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01102477
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00940346
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00359610
84P53_22387025_ChIP-Seq_ESCs_Mouse0.99344018
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98896349
86CMYC_18555785_Chip-Seq_ESCs_Mouse0.98842476
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98598473
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98581174
89FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98313550
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98000193
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97634067
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.97093209
93GATA1_22025678_ChIP-Seq_K562_Human0.96379032
94MYC_18940864_ChIP-ChIP_HL60_Human0.96227445
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96080454
96RNF2_27304074_Chip-Seq_NSC_Mouse0.95955675
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95654723
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95020136
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94681815
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94358220
101SOX9_26525672_Chip-Seq_HEART_Mouse0.94297556
102ER_23166858_ChIP-Seq_MCF-7_Human0.94282739
103AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93018899
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92134038
105TRIM28_21343339_ChIP-Seq_HEK293_Human0.91673076
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91062998
107RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91002357
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84786233
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.84520306
110GATA4_25053715_ChIP-Seq_YYC3_Human0.84519800
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83270413
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81210712
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80771766
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78667574
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.77684932
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76926657
117GBX2_23144817_ChIP-Seq_PC3_Human0.72302532
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72155297
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.71837443
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71182674
121RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70254305
122EGR1_19032775_ChIP-ChIP_M12_Human0.69712347
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.69330485
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69172988
125SOX2_20726797_ChIP-Seq_SW620_Human0.68810715
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68582511
127CBP_21632823_ChIP-Seq_H3396_Human0.67881627
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67467254
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67238357
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66907718
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.66605051
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64363654
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63462842
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.61468661
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.61203790
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.60849284
137* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60297213
138MYC_19915707_ChIP-ChIP_AK7_Human0.59968768
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.59872665
140PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.59403336
141AR_21572438_ChIP-Seq_LNCaP_Human0.59057666
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.58952099
143CRX_20693478_ChIP-Seq_RETINA_Mouse0.58786387
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.58636861
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.57942198
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57584544
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.57331397
148AR_20517297_ChIP-Seq_VCAP_Human0.56251685
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55532920
150CEBPB_22108803_ChIP-Seq_LS180_Human0.54065318
151BCAT_22108803_ChIP-Seq_LS180_Human0.53831321
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53215329
153RUNX1_27457419_Chip-Seq_LIVER_Mouse0.53124447
154SOX2_19829295_ChIP-Seq_ESCs_Human0.52842144
155NANOG_19829295_ChIP-Seq_ESCs_Human0.52842144
156TP63_23658742_ChIP-Seq_EP156T_Human0.52501985
157ZFP57_27257070_Chip-Seq_ESCs_Mouse0.51942118
158STAT1_17558387_ChIP-Seq_HELA_Human0.51905003
159GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.51840212
160CDX2_22108803_ChIP-Seq_LS180_Human0.51471529
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.51454643
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50190534
163P300_19829295_ChIP-Seq_ESCs_Human0.49818715
164SUZ12_27294783_Chip-Seq_NPCs_Mouse0.49622087
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.49330470
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.49324720
167SMAD1_18555785_Chip-Seq_ESCs_Mouse0.48814724
168ZNF217_24962896_ChIP-Seq_MCF-7_Human0.48331529
169PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.48322356
170NCOR_22424771_ChIP-Seq_293T_Human0.47856387
171OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.47706586
172RARA_24833708_ChIP-Seq_LIVER_Mouse0.46307752
173GATA1_19941826_ChIP-Seq_K562_Human0.46295150
174NFE2_27457419_Chip-Seq_LIVER_Mouse0.45796326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15065988
2MP0005360_urolithiasis7.20502361
3MP0005085_abnormal_gallbladder_physiolo6.20784278
4MP0005365_abnormal_bile_salt5.78250863
5MP0008875_abnormal_xenobiotic_pharmacok4.93477903
6MP0003806_abnormal_nucleotide_metabolis4.50520798
7MP0003941_abnormal_skin_development4.06936583
8MP0003252_abnormal_bile_duct3.57769941
9MP0010329_abnormal_lipoprotein_level3.39838116
10MP0009840_abnormal_foam_cell3.24416628
11MP0005083_abnormal_biliary_tract3.23389402
12MP0003195_calcinosis3.01031723
13MP0003890_abnormal_embryonic-extraembry2.96844607
14MP0002102_abnormal_ear_morphology2.64987278
15MP0005332_abnormal_amino_acid2.63352785
16MP0001666_abnormal_nutrient_absorption2.53123070
17* MP0002118_abnormal_lipid_homeostasis2.15891449
18MP0001529_abnormal_vocalization2.11783389
19MP0003191_abnormal_cellular_cholesterol1.99791108
20MP0000609_abnormal_liver_physiology1.96820517
21MP0003567_abnormal_fetal_cardiomyocyte1.93933078
22MP0003122_maternal_imprinting1.93652228
23MP0004019_abnormal_vitamin_homeostasis1.91468488
24MP0003868_abnormal_feces_composition1.86583414
25* MP0003937_abnormal_limbs/digits/tail_de1.82375914
26MP0004215_abnormal_myocardial_fiber1.78930154
27MP0005451_abnormal_body_composition1.71616744
28MP0001984_abnormal_olfaction1.70720836
29MP0009697_abnormal_copulation1.66191498
30MP0003121_genomic_imprinting1.63954069
31MP0006054_spinal_hemorrhage1.63228136
32MP0003011_delayed_dark_adaptation1.63048821
33MP0005319_abnormal_enzyme/_coenzyme1.62284403
34MP0001764_abnormal_homeostasis1.60377939
35MP0002138_abnormal_hepatobiliary_system1.60316378
36MP0001293_anophthalmia1.59745828
37MP0005584_abnormal_enzyme/coenzyme_acti1.59508279
38MP0003119_abnormal_digestive_system1.58273079
39MP0004957_abnormal_blastocyst_morpholog1.54360077
40MP0003136_yellow_coat_color1.48766105
41MP0003186_abnormal_redox_activity1.44669157
42MP0010094_abnormal_chromosome_stability1.42641153
43MP0003656_abnormal_erythrocyte_physiolo1.42013932
44MP0008058_abnormal_DNA_repair1.41779780
45MP0000604_amyloidosis1.41249170
46MP0002697_abnormal_eye_size1.37236198
47MP0003690_abnormal_glial_cell1.36494851
48MP0000516_abnormal_urinary_system1.35100153
49MP0005367_renal/urinary_system_phenotyp1.35100153
50MP0006072_abnormal_retinal_apoptosis1.32671156
51MP0004145_abnormal_muscle_electrophysio1.32248858
52MP0004133_heterotaxia1.32036697
53MP0002938_white_spotting1.31931191
54MP0005187_abnormal_penis_morphology1.31610579
55MP0008932_abnormal_embryonic_tissue1.31341710
56* MP0002233_abnormal_nose_morphology1.29229533
57MP0001188_hyperpigmentation1.26716268
58MP0003123_paternal_imprinting1.24567690
59MP0003329_amyloid_beta_deposits1.23073499
60MP0002736_abnormal_nociception_after1.22724037
61* MP0001177_atelectasis1.22610028
62MP0004272_abnormal_basement_membrane1.20533826
63MP0004270_analgesia1.20360947
64MP0000462_abnormal_digestive_system1.17696052
65MP0005408_hypopigmentation1.17579598
66MP0005647_abnormal_sex_gland1.12712021
67MP0002837_dystrophic_cardiac_calcinosis1.12280391
68MP0003693_abnormal_embryo_hatching1.11491776
69MP0003880_abnormal_central_pattern1.11406652
70MP0010234_abnormal_vibrissa_follicle1.10874725
71MP0001286_abnormal_eye_development1.09292814
72MP0002084_abnormal_developmental_patter1.08954382
73MP0009643_abnormal_urine_homeostasis1.07400642
74MP0005253_abnormal_eye_physiology1.05552210
75MP0003385_abnormal_body_wall1.04375039
76MP0008789_abnormal_olfactory_epithelium1.03816526
77MP0009764_decreased_sensitivity_to1.01944255
78MP0000920_abnormal_myelination1.01166690
79MP0003283_abnormal_digestive_organ1.00791919
80MP0001672_abnormal_embryogenesis/_devel0.99814710
81MP0005380_embryogenesis_phenotype0.99814710
82* MP0000598_abnormal_liver_morphology0.97566067
83MP0000778_abnormal_nervous_system0.97542927
84MP0005551_abnormal_eye_electrophysiolog0.96020921
85MP0005394_taste/olfaction_phenotype0.95081614
86MP0005499_abnormal_olfactory_system0.95081614
87MP0002254_reproductive_system_inflammat0.94763364
88* MP0009672_abnormal_birth_weight0.94707530
89MP0009763_increased_sensitivity_to0.93841569
90MP0003984_embryonic_growth_retardation0.93399553
91MP0002088_abnormal_embryonic_growth/wei0.93357399
92MP0002876_abnormal_thyroid_physiology0.93094406
93MP0002234_abnormal_pharynx_morphology0.91535726
94MP0003111_abnormal_nucleus_morphology0.90955029
95MP0008057_abnormal_DNA_replication0.90852561
96MP0004084_abnormal_cardiac_muscle0.87172773
97* MP0009703_decreased_birth_body0.86936834
98* MP0003755_abnormal_palate_morphology0.85499962
99MP0003787_abnormal_imprinting0.85089964
100MP0008877_abnormal_DNA_methylation0.84264020
101MP0001299_abnormal_eye_distance/0.83267052
102MP0001661_extended_life_span0.83111263
103MP0008469_abnormal_protein_level0.82762950
104MP0002085_abnormal_embryonic_tissue0.82335725
105* MP0002111_abnormal_tail_morphology0.82078064
106MP0009765_abnormal_xenobiotic_induced0.81882316
107MP0005636_abnormal_mineral_homeostasis0.79559923
108MP0008775_abnormal_heart_ventricle0.79476847
109MP0006292_abnormal_olfactory_placode0.79437067
110MP0001697_abnormal_embryo_size0.78527065
111MP0009642_abnormal_blood_homeostasis0.78360410
112MP0001730_embryonic_growth_arrest0.78253925
113MP0000537_abnormal_urethra_morphology0.78119602
114MP0005376_homeostasis/metabolism_phenot0.76996169
115MP0004381_abnormal_hair_follicle0.76526217
116MP0009780_abnormal_chondrocyte_physiolo0.74492348
117MP0005391_vision/eye_phenotype0.74152876
118MP0005084_abnormal_gallbladder_morpholo0.74140579
119MP0001486_abnormal_startle_reflex0.73796530
120* MP0004197_abnormal_fetal_growth/weight/0.73208029
121MP0003935_abnormal_craniofacial_develop0.73114438
122MP0003077_abnormal_cell_cycle0.72447781
123MP0002734_abnormal_mechanical_nocicepti0.71121287
124MP0003861_abnormal_nervous_system0.70017535
125MP0002127_abnormal_cardiovascular_syste0.69950581
126MP0003137_abnormal_impulse_conducting0.69412530
127MP0005334_abnormal_fat_pad0.68478989
128MP0000639_abnormal_adrenal_gland0.68334139
129MP0005535_abnormal_body_temperature0.68148255
130MP0006036_abnormal_mitochondrial_physio0.67422329
131MP0003705_abnormal_hypodermis_morpholog0.65701594
132MP0004130_abnormal_muscle_cell0.64086809
133MP0005670_abnormal_white_adipose0.62852232
134* MP0002078_abnormal_glucose_homeostasis0.62475801
135MP0009384_cardiac_valve_regurgitation0.60241280
136MP0003718_maternal_effect0.57987389
137MP0010368_abnormal_lymphatic_system0.57122077
138MP0003724_increased_susceptibility_to0.56815549
139MP0006082_CNS_inflammation0.56064654
140MP0003075_altered_response_to0.54664209
141MP0005448_abnormal_energy_balance0.54199752
142MP0005266_abnormal_metabolism0.53621429
143* MP0002971_abnormal_brown_adipose0.51181410
144MP0005395_other_phenotype0.50695284
145MP0002822_catalepsy0.50306379
146MP0002796_impaired_skin_barrier0.48906028
147MP0002090_abnormal_vision0.46681226
148MP0008438_abnormal_cutaneous_collagen0.45807717
149MP0000579_abnormal_nail_morphology0.45669573
150MP0003632_abnormal_nervous_system0.45180151
151MP0001243_abnormal_dermal_layer0.44981444
152MP0005164_abnormal_response_to0.44271816
153MP0006035_abnormal_mitochondrial_morpho0.44031700
154MP0005464_abnormal_platelet_physiology0.43717335
155MP0008874_decreased_physiological_sensi0.43655734
156MP0001756_abnormal_urination0.43320653
157MP0005058_abnormal_lysosome_morphology0.42656311
158MP0004782_abnormal_surfactant_physiolog0.42443729
159MP0004142_abnormal_muscle_tone0.42125522
160MP0005166_decreased_susceptibility_to0.41645074
161MP0008873_increased_physiological_sensi0.41281921
162MP0002295_abnormal_pulmonary_circulatio0.39749237
163MP0009053_abnormal_anal_canal0.39102658
164MP0000647_abnormal_sebaceous_gland0.39038773
165MP0000427_abnormal_hair_cycle0.38402737
166MP0000230_abnormal_systemic_arterial0.37195900
167MP0003638_abnormal_response/metabolism_0.35629725
168MP0002132_abnormal_respiratory_system0.35028128
169MP0004883_abnormal_blood_vessel0.34813270
170MP0003950_abnormal_plasma_membrane0.34740984
171MP0002060_abnormal_skin_morphology0.34514624
172MP0003953_abnormal_hormone_level0.34432920
173MP0003436_decreased_susceptibility_to0.34039087
174MP0000566_synostosis0.34015191
175MP0002136_abnormal_kidney_physiology0.33809265
176* MP0005220_abnormal_exocrine_pancreas0.32907156
177MP0005248_abnormal_Harderian_gland0.32484296
178MP0003631_nervous_system_phenotype0.31956920
179MP0003633_abnormal_nervous_system0.30107901

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.09718689
2Deep venous thrombosis (HP:0002625)7.02876387
3* Intrahepatic cholestasis (HP:0001406)6.89903635
4Prolonged partial thromboplastin time (HP:0003645)6.32365374
5Xanthomatosis (HP:0000991)6.25351482
6Hypobetalipoproteinemia (HP:0003563)6.16831529
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.09888497
8Hyperlipoproteinemia (HP:0010980)5.45052491
9Complement deficiency (HP:0004431)4.87999300
10Epidermoid cyst (HP:0200040)4.80736625
11Hypolipoproteinemia (HP:0010981)4.51516288
12Joint hemorrhage (HP:0005261)4.44686123
13Abnormality of methionine metabolism (HP:0010901)4.34777794
14Fat malabsorption (HP:0002630)4.25715772
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.23137667
16Hyperammonemia (HP:0001987)4.18617343
17Hyperglycinemia (HP:0002154)4.09477851
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09428897
19Abnormality of the common coagulation pathway (HP:0010990)4.08512127
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.02787116
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95365116
22Abnormality of glycine metabolism (HP:0010895)3.82258827
23Abnormality of serine family amino acid metabolism (HP:0010894)3.82258827
24Ketosis (HP:0001946)3.80971471
25Hypoalphalipoproteinemia (HP:0003233)3.80249091
26Conjugated hyperbilirubinemia (HP:0002908)3.79416394
27Hyperglycinuria (HP:0003108)3.53721580
28Abnormality of complement system (HP:0005339)3.51369239
29Hypercholesterolemia (HP:0003124)3.50886793
30Abnormality of the intrinsic pathway (HP:0010989)3.46534018
31Steatorrhea (HP:0002570)3.38422759
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28642214
33Hypoglycemic coma (HP:0001325)3.28610210
34Abnormality of fatty-acid metabolism (HP:0004359)3.15080293
35Abnormality of pyrimidine metabolism (HP:0004353)3.10732981
36Bifid tongue (HP:0010297)3.00202329
37Abnormality of serum amino acid levels (HP:0003112)2.95003580
38* Hyperbilirubinemia (HP:0002904)2.94132962
39Cortical dysplasia (HP:0002539)2.91545292
40Hyperinsulinemic hypoglycemia (HP:0000825)2.87225581
41Skin nodule (HP:0200036)2.83080697
42Delayed CNS myelination (HP:0002188)2.81872763
43Myocardial infarction (HP:0001658)2.76518371
44Vascular calcification (HP:0004934)2.70515575
45Spontaneous abortion (HP:0005268)2.68900561
46Pancreatic islet-cell hyperplasia (HP:0004510)2.67235030
47Abnormal lung lobation (HP:0002101)2.66290217
48Hepatocellular carcinoma (HP:0001402)2.65755111
49Abnormality of the labia minora (HP:0012880)2.64821095
50Volvulus (HP:0002580)2.58245737
51Abnormality of nucleobase metabolism (HP:0010932)2.56245530
52Abnormal gallbladder physiology (HP:0012438)2.55755227
53Cholecystitis (HP:0001082)2.55755227
54Ketoacidosis (HP:0001993)2.55665658
55Metabolic acidosis (HP:0001942)2.55304136
56Absent eyebrow (HP:0002223)2.54661617
57Colon cancer (HP:0003003)2.49674325
58Lethargy (HP:0001254)2.49163785
59Hepatoblastoma (HP:0002884)2.46981584
60Mitral stenosis (HP:0001718)2.44921819
61Amyloidosis (HP:0011034)2.43799570
62Methylmalonic acidemia (HP:0002912)2.42798272
63Hypochromic microcytic anemia (HP:0004840)2.42192702
64Systemic lupus erythematosus (HP:0002725)2.40947672
65Cerebral edema (HP:0002181)2.40799023
66Cholelithiasis (HP:0001081)2.40673097
67Cardiovascular calcification (HP:0011915)2.40405730
68Papillary thyroid carcinoma (HP:0002895)2.36975781
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34403781
70Dicarboxylic aciduria (HP:0003215)2.34403781
71Irritability (HP:0000737)2.32933435
72Abnormality of purine metabolism (HP:0004352)2.29001804
73Hypophosphatemic rickets (HP:0004912)2.28330323
74* Abnormal gallbladder morphology (HP:0012437)2.25949196
75Glomerulonephritis (HP:0000099)2.25508608
76Right ventricular cardiomyopathy (HP:0011663)2.25055409
77Scrotal hypoplasia (HP:0000046)2.24961358
78Reduced antithrombin III activity (HP:0001976)2.18997126
79Opisthotonus (HP:0002179)2.18207386
80Neurofibrillary tangles (HP:0002185)2.18095812
81Brushfield spots (HP:0001088)2.17254208
82Hypoglycemic seizures (HP:0002173)2.16945961
83Abnormality of glycolysis (HP:0004366)2.16810608
84Increased serum pyruvate (HP:0003542)2.16810608
85Spastic paraparesis (HP:0002313)2.15882246
86Hypoplastic pelvis (HP:0008839)2.14808585
87Recurrent gram-negative bacterial infections (HP:0005420)2.14645497
88Gonadotropin excess (HP:0000837)2.14519578
89Symptomatic seizures (HP:0011145)2.14207615
90Enlarged kidneys (HP:0000105)2.12593414
91Gingival bleeding (HP:0000225)2.09848784
92Genital tract atresia (HP:0001827)2.08751117
93Intestinal atresia (HP:0011100)2.08263372
94Rickets (HP:0002748)2.07831827
95Neoplasm of the adrenal gland (HP:0100631)2.05672847
96Malnutrition (HP:0004395)2.05451364
97Vaginal atresia (HP:0000148)2.02673063
98Spastic diplegia (HP:0001264)2.02320696
99Sensorimotor neuropathy (HP:0007141)2.01418654
100Pancreatitis (HP:0001733)1.99652917
101Abnormal tarsal ossification (HP:0008369)1.98469987
102Vomiting (HP:0002013)1.97218126
103Abnormality of chromosome stability (HP:0003220)1.95463303
104Parakeratosis (HP:0001036)1.93847598
105Short tibia (HP:0005736)1.93174103
106Supernumerary spleens (HP:0009799)1.92559987
107Thyroid carcinoma (HP:0002890)1.91187964
108Abnormality of proline metabolism (HP:0010907)1.91181081
109Hydroxyprolinuria (HP:0003080)1.91181081
110Menorrhagia (HP:0000132)1.90664503
111Embryonal renal neoplasm (HP:0011794)1.88876845
112Protuberant abdomen (HP:0001538)1.88780712
113Renal hypoplasia (HP:0000089)1.88583521
114Neonatal onset (HP:0003623)1.88342608
115Meckel diverticulum (HP:0002245)1.87055552
116* Abnormality of the gallbladder (HP:0005264)1.85964567
117Absent hair (HP:0002298)1.85419482
118Abnormality of the duodenum (HP:0002246)1.84938053
119Renal cortical cysts (HP:0000803)1.84737845
120Abnormality of vitamin metabolism (HP:0100508)1.84448663
121* Myelomeningocele (HP:0002475)1.83760203
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.83587464
123Abnormal cartilage morphology (HP:0002763)1.83006074
124Esophageal varix (HP:0002040)1.82417790
125Hemorrhage of the eye (HP:0011885)1.82202738
126Postnatal microcephaly (HP:0005484)1.82035727
127Epiphyseal stippling (HP:0010655)1.81818827
128Abnormality of endocrine pancreas physiology (HP:0012093)1.81043331
129Abnormality of the pancreatic islet cells (HP:0006476)1.81043331
130Labial hypoplasia (HP:0000066)1.80753191
131Abnormality of the ileum (HP:0001549)1.80283091
132Generalized aminoaciduria (HP:0002909)1.78712885
133Gout (HP:0001997)1.78605291
134Alkalosis (HP:0001948)1.76601609
135Megaloblastic anemia (HP:0001889)1.74501713
136Paraparesis (HP:0002385)1.73917994
137Hypoplastic female external genitalia (HP:0012815)1.73631865
138Septo-optic dysplasia (HP:0100842)1.73524121
139Gait imbalance (HP:0002141)1.71463677
140Congenital primary aphakia (HP:0007707)1.71348133
141Absent eyelashes (HP:0000561)1.71297894
142Thrombophlebitis (HP:0004418)1.70979771
143Medial flaring of the eyebrow (HP:0010747)1.70681186
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.70343203
145Small intestinal stenosis (HP:0012848)1.70071510
146Duodenal stenosis (HP:0100867)1.70071510
147Ependymoma (HP:0002888)1.68558321
148Type I transferrin isoform profile (HP:0003642)1.68345408
149Bile duct proliferation (HP:0001408)1.67819172
150Abnormal biliary tract physiology (HP:0012439)1.67819172
151Abnormality of urine glucose concentration (HP:0011016)1.67735365
152Glycosuria (HP:0003076)1.67735365
153Nephroblastoma (Wilms tumor) (HP:0002667)1.67157988
154Calf muscle hypertrophy (HP:0008981)1.65939562
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.65731126
156Abnormality of the calf musculature (HP:0001430)1.64754785
157Rhabdomyosarcoma (HP:0002859)1.63881851
158Methylmalonic aciduria (HP:0012120)1.62836320
159Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62578254
160Abnormality of alanine metabolism (HP:0010916)1.62578254
161Hyperalaninemia (HP:0003348)1.62578254
162Hypothermia (HP:0002045)1.62571497
163Poor suck (HP:0002033)1.61448140
164Abnormal glycosylation (HP:0012345)1.59825105
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59825105
166Abnormal protein N-linked glycosylation (HP:0012347)1.59825105
167Abnormal protein glycosylation (HP:0012346)1.59825105
168Drooling (HP:0002307)1.59425282
169Abolished electroretinogram (ERG) (HP:0000550)1.59207884
170Medulloblastoma (HP:0002885)1.58904532
171Abnormal hair whorl (HP:0010721)1.58870410
172Progressive inability to walk (HP:0002505)1.56300235
173Preaxial foot polydactyly (HP:0001841)1.55800594
174Micropenis (HP:0000054)1.53039622
175Abnormality of vitamin B metabolism (HP:0004340)1.52741204
176Bifid scrotum (HP:0000048)1.52380410
177Glioma (HP:0009733)1.52124838
178Clitoromegaly (HP:0000057)1.50603197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.39750019
2SIK14.08732870
3FGFR43.55084214
4ERBB43.34525665
5TRIM282.84499133
6TSSK62.79944990
7PBK2.71402120
8STK392.70951293
9MKNK22.64425536
10EPHB12.61076096
11WNK32.44178193
12ERN12.37356242
13PLK42.35321074
14INSRR2.34356350
15MST42.33877160
16SRPK12.27492784
17FGFR22.26659112
18MST1R2.23703624
19BMPR1B2.19131639
20MET2.12097899
21TAOK32.09550738
22OBSCN2.07200706
23TTK2.05534035
24PNCK2.03798784
25EIF2AK32.02774699
26WEE12.02282486
27MKNK12.01244298
28NEK12.01185569
29PLK31.99726816
30OXSR11.85323404
31MAP3K141.82954397
32ACVR1B1.81806625
33PKN11.75662846
34PKN21.72454381
35ERBB31.72319775
36BUB11.67952023
37MAP2K41.62751708
38MAP3K41.59510711
39BCR1.52258178
40PIK3CG1.50684696
41ABL21.49004295
42PLK21.44797683
43AKT31.36395344
44EIF2AK11.32814049
45CSNK1G31.30417960
46BRSK21.27908116
47NEK91.26196102
48CSNK1G11.26050804
49ZAK1.23664633
50SGK2231.20067170
51SGK4941.20067170
52FRK1.19480869
53LATS11.17128643
54CSNK1A1L1.14091282
55DAPK21.13748936
56CSNK1G21.10440610
57TYK21.10178464
58CDC71.09546227
59MAPK111.09478263
60FGFR11.09052427
61PRKCQ1.08497782
62TAF11.03814735
63MAP4K21.01213382
64PLK11.01053688
65CAMK2G1.00907004
66FER0.98042506
67PRKAA20.95641351
68STK38L0.94299831
69CASK0.90930311
70MAPK150.90871161
71MAPK40.88008853
72STK30.84226308
73PINK10.84170382
74MAP3K120.84040038
75GSK3A0.83973428
76STK160.82967954
77EPHA30.82747961
78JAK20.82233858
79MAPK130.82027514
80IRAK20.82001909
81PIK3CA0.80952208
82VRK10.80844333
83EIF2AK20.79837069
84PRPF4B0.78898241
85PRKCZ0.78495869
86MAP3K30.77827714
87MAP3K70.77641948
88TBK10.77126035
89JAK10.77071678
90ERBB20.76730038
91CSK0.76111643
92LIMK10.75112751
93PAK30.74232038
94PRKACG0.74184859
95MAP2K70.72854502
96FLT30.72703827
97MAP3K130.71965862
98PTK60.70536081
99NTRK10.70432270
100TESK20.69010544
101EPHA40.68007049
102MINK10.67742354
103WNK40.65596207
104MAPK120.64520760
105CAMK1D0.62442594
106MARK10.62336668
107MAPKAPK50.61827505
108CAMK1G0.61357449
109MAPK70.61266420
110YES10.59310442
111ATM0.58842072
112PDPK10.58351369
113TGFBR10.58226762
114IKBKE0.57929520
115TIE10.57763323
116KDR0.56423745
117TNIK0.54897570
118BRD40.54872517
119LATS20.54163498
120DMPK0.54061118
121DYRK30.53819812
122IRAK10.53712858
123IGF1R0.53602240
124FGR0.53128932
125PASK0.53035322
126CCNB10.51824624
127CSNK1E0.51341073
128CSF1R0.49952997
129CAMK2B0.47906549
130IRAK30.47556652
131DYRK20.47394900
132ITK0.47144144
133SGK20.47089705
134PTK20.46150770
135NEK60.45999972
136PRKCG0.44235578
137NEK20.43362486
138GRK10.43339891
139MAP2K10.43332531
140MAP3K20.42414031
141SGK30.42199220
142ADRBK20.41375892
143RPS6KA40.41349364
144PRKCH0.39478168
145BRAF0.39217539
146CAMK2A0.38875821
147NLK0.38270239
148SIK30.37742091
149ABL10.37400548
150PRKCA0.36914420
151PRKAA10.36483396
152CHEK20.35947254
153NUAK10.35856418
154ATR0.34586006
155GRK60.34433077
156UHMK10.34189406
157PRKDC0.34107704
158PRKG10.34093577
159CAMK2D0.33989459
160PRKCE0.33722274
161EGFR0.33564277
162CSNK1A10.32414821
163PRKACA0.31593076
164NTRK30.31373180
165BRSK10.31153069
166PRKACB0.31111256
167CDK30.30163976
168CHEK10.29760433

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.22847627
2Nitrogen metabolism_Homo sapiens_hsa009103.47179950
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14743454
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.14671025
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86406573
6Arginine biosynthesis_Homo sapiens_hsa002202.70110212
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51291781
8Complement and coagulation cascades_Homo sapiens_hsa046102.51074837
9Tryptophan metabolism_Homo sapiens_hsa003802.48975170
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42340700
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39097146
12Fatty acid degradation_Homo sapiens_hsa000712.35302224
13* Steroid biosynthesis_Homo sapiens_hsa001002.32889399
14Butanoate metabolism_Homo sapiens_hsa006502.29236964
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27273004
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18452788
17Peroxisome_Homo sapiens_hsa041462.11984992
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11707251
19Histidine metabolism_Homo sapiens_hsa003402.06248786
20Fatty acid elongation_Homo sapiens_hsa000622.06248468
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.99217388
22Fatty acid metabolism_Homo sapiens_hsa012121.97680666
23Propanoate metabolism_Homo sapiens_hsa006401.97096512
24Chemical carcinogenesis_Homo sapiens_hsa052041.94537258
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93784401
26PPAR signaling pathway_Homo sapiens_hsa033201.81336786
27Sulfur metabolism_Homo sapiens_hsa009201.74565783
28Non-homologous end-joining_Homo sapiens_hsa034501.71884341
29Caffeine metabolism_Homo sapiens_hsa002321.70995609
30Retinol metabolism_Homo sapiens_hsa008301.69703625
31beta-Alanine metabolism_Homo sapiens_hsa004101.65368498
32Proteasome_Homo sapiens_hsa030501.65016935
33Staphylococcus aureus infection_Homo sapiens_hsa051501.64499561
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62447457
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59050232
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.51003786
37Phenylalanine metabolism_Homo sapiens_hsa003601.49645968
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48016093
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46854280
40Tyrosine metabolism_Homo sapiens_hsa003501.40911864
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38740823
42Pyruvate metabolism_Homo sapiens_hsa006201.38566092
43Bile secretion_Homo sapiens_hsa049761.36780842
44Selenocompound metabolism_Homo sapiens_hsa004501.29768956
45Starch and sucrose metabolism_Homo sapiens_hsa005001.20248408
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18820718
47Basal transcription factors_Homo sapiens_hsa030221.16491460
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16429867
49Fat digestion and absorption_Homo sapiens_hsa049751.13176942
50Mismatch repair_Homo sapiens_hsa034301.11787367
51ABC transporters_Homo sapiens_hsa020101.10922479
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.09746655
53Folate biosynthesis_Homo sapiens_hsa007901.08144070
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02199353
55Arginine and proline metabolism_Homo sapiens_hsa003301.02057321
56Vitamin B6 metabolism_Homo sapiens_hsa007501.02051405
57Biosynthesis of amino acids_Homo sapiens_hsa012300.98530401
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97851571
59Carbon metabolism_Homo sapiens_hsa012000.97371223
60RNA degradation_Homo sapiens_hsa030180.97023350
61Vitamin digestion and absorption_Homo sapiens_hsa049770.90655606
62RNA transport_Homo sapiens_hsa030130.88102897
63Fatty acid biosynthesis_Homo sapiens_hsa000610.87208708
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.80859233
65RNA polymerase_Homo sapiens_hsa030200.80200939
66Fanconi anemia pathway_Homo sapiens_hsa034600.79597106
67Glutathione metabolism_Homo sapiens_hsa004800.79386535
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.78445434
69TGF-beta signaling pathway_Homo sapiens_hsa043500.74580543
70Sulfur relay system_Homo sapiens_hsa041220.74466905
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73824375
72Glycerolipid metabolism_Homo sapiens_hsa005610.68006020
73Cell cycle_Homo sapiens_hsa041100.67522647
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66969697
75N-Glycan biosynthesis_Homo sapiens_hsa005100.64485193
76Hippo signaling pathway_Homo sapiens_hsa043900.61258188
77Oocyte meiosis_Homo sapiens_hsa041140.61212198
78Lysine degradation_Homo sapiens_hsa003100.58137331
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57161507
80Homologous recombination_Homo sapiens_hsa034400.56354549
81Nicotine addiction_Homo sapiens_hsa050330.56225573
82Nucleotide excision repair_Homo sapiens_hsa034200.53965661
83mRNA surveillance pathway_Homo sapiens_hsa030150.52283515
84* Metabolic pathways_Homo sapiens_hsa011000.50289339
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50223001
86Basal cell carcinoma_Homo sapiens_hsa052170.49174999
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48674195
88Spliceosome_Homo sapiens_hsa030400.47808206
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46977436
90Pentose phosphate pathway_Homo sapiens_hsa000300.46431796
91Hedgehog signaling pathway_Homo sapiens_hsa043400.44803563
92Linoleic acid metabolism_Homo sapiens_hsa005910.43827811
93One carbon pool by folate_Homo sapiens_hsa006700.42957437
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40735044
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38394855
96DNA replication_Homo sapiens_hsa030300.38389953
97Tight junction_Homo sapiens_hsa045300.38138455
98Parkinsons disease_Homo sapiens_hsa050120.37917564
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35902560
100Prion diseases_Homo sapiens_hsa050200.33193775
101p53 signaling pathway_Homo sapiens_hsa041150.31161434
102Ether lipid metabolism_Homo sapiens_hsa005650.30204730
103Purine metabolism_Homo sapiens_hsa002300.30186026
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27580848
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24482517
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.24226020
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.16322488
108Ovarian steroidogenesis_Homo sapiens_hsa049130.11896495
109Fructose and mannose metabolism_Homo sapiens_hsa000510.11866803
110Galactose metabolism_Homo sapiens_hsa000520.10469816
111Insulin resistance_Homo sapiens_hsa049310.07143421
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05976533
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03197050
114Arachidonic acid metabolism_Homo sapiens_hsa005900.02794784
115Pertussis_Homo sapiens_hsa05133-0.2249792
116Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2239717
117Protein digestion and absorption_Homo sapiens_hsa04974-0.2224804
118Mineral absorption_Homo sapiens_hsa04978-0.2188475
119Renin-angiotensin system_Homo sapiens_hsa04614-0.2054286
120Phagosome_Homo sapiens_hsa04145-0.1882826
121Lysosome_Homo sapiens_hsa04142-0.1688249
122Oxidative phosphorylation_Homo sapiens_hsa00190-0.1573756
123Hepatitis C_Homo sapiens_hsa05160-0.1513576
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1357484
125Sphingolipid metabolism_Homo sapiens_hsa00600-0.1256503
126Malaria_Homo sapiens_hsa05144-0.1178845
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1123408
128Regulation of autophagy_Homo sapiens_hsa04140-0.1037518
129Protein export_Homo sapiens_hsa03060-0.0972638
130Glucagon signaling pathway_Homo sapiens_hsa04922-0.0846078
131African trypanosomiasis_Homo sapiens_hsa05143-0.0688241
132AMPK signaling pathway_Homo sapiens_hsa04152-0.0572929

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