SCAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoskeletal anchoring at plasma membrane (GO:0007016)4.13542506
2negative regulation of cell size (GO:0045792)4.08155728
3activation of Rac GTPase activity (GO:0032863)3.98656437
4synaptic vesicle maturation (GO:0016188)3.91328411
5negative regulation of erythrocyte differentiation (GO:0045647)3.88209311
6sodium ion export (GO:0071436)3.82662543
7COPI coating of Golgi vesicle (GO:0048205)3.75429481
8Golgi transport vesicle coating (GO:0048200)3.75429481
9layer formation in cerebral cortex (GO:0021819)3.69836370
10regulation of NFAT protein import into nucleus (GO:0051532)3.66433558
11pre-miRNA processing (GO:0031054)3.65163369
12semaphorin-plexin signaling pathway (GO:0071526)3.62103250
13regulation of mammary gland epithelial cell proliferation (GO:0033599)3.60584252
14locomotory exploration behavior (GO:0035641)3.57011853
15positive regulation of histone deacetylation (GO:0031065)3.56897858
16protein retention in ER lumen (GO:0006621)3.55198834
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39424731
18regulation of glucose import in response to insulin stimulus (GO:2001273)3.34757045
19plasma membrane repair (GO:0001778)3.33694271
20adherens junction assembly (GO:0034333)3.19389033
21stress fiber assembly (GO:0043149)3.16931819
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16410453
23barbed-end actin filament capping (GO:0051016)3.16277652
24intracellular estrogen receptor signaling pathway (GO:0030520)3.15731750
25regulation of ARF GTPase activity (GO:0032312)3.15694099
26mannose metabolic process (GO:0006013)3.11006413
27cell communication by electrical coupling (GO:0010644)3.10168877
28activation of MAPKKK activity (GO:0000185)3.06372018
29basement membrane organization (GO:0071711)3.06208117
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05563152
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.04824959
32regulation of early endosome to late endosome transport (GO:2000641)3.03645044
33establishment of nucleus localization (GO:0040023)3.00770482
34hemidesmosome assembly (GO:0031581)3.00629986
35regulation of hippo signaling (GO:0035330)3.00458815
36peptidyl-lysine dimethylation (GO:0018027)2.99852734
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97847485
38atrioventricular valve morphogenesis (GO:0003181)2.95406681
39regulation of translational fidelity (GO:0006450)2.93814214
40synaptic vesicle docking involved in exocytosis (GO:0016081)2.90921589
41planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90316087
42cell migration in hindbrain (GO:0021535)2.90068497
43cerebellar Purkinje cell layer development (GO:0021680)2.89338511
44vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88578920
45establishment of apical/basal cell polarity (GO:0035089)2.86775329
46activation of protein kinase A activity (GO:0034199)2.86749189
47positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85191145
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84720220
49maternal placenta development (GO:0001893)2.84397826
50positive regulation of fibroblast migration (GO:0010763)2.82940102
51regulation of translational termination (GO:0006449)2.82247706
52polarized epithelial cell differentiation (GO:0030859)2.81659828
53desmosome organization (GO:0002934)2.81522801
54cell-substrate adherens junction assembly (GO:0007045)2.80940561
55focal adhesion assembly (GO:0048041)2.80940561
56protein targeting to plasma membrane (GO:0072661)2.77985972
57protein localization to endosome (GO:0036010)2.77315139
58positive regulation of protein dephosphorylation (GO:0035307)2.76595975
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75618010
60signal complex assembly (GO:0007172)2.73673429
61regulation of ARF protein signal transduction (GO:0032012)2.73539133
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73227160
63positive regulation of receptor recycling (GO:0001921)2.72457125
64positive regulation of Cdc42 GTPase activity (GO:0043089)2.72178261
65regulation of extracellular matrix disassembly (GO:0010715)2.72130619
66positive regulation of synapse maturation (GO:0090129)2.70529528
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.69546115
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68077515
69skin morphogenesis (GO:0043589)2.67865032
70negative regulation of potassium ion transmembrane transport (GO:1901380)2.67669708
71establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.66171671
72regulation of cholesterol homeostasis (GO:2000188)2.65341145
73negative regulation of fatty acid transport (GO:2000192)2.64922793
74heterochromatin organization (GO:0070828)2.64201791
75neuromuscular process controlling balance (GO:0050885)2.63989984
76negative regulation of nucleotide catabolic process (GO:0030812)2.60961703
77modulation by symbiont of host cellular process (GO:0044068)2.60398381
78proline biosynthetic process (GO:0006561)2.60256125
79glucose 6-phosphate metabolic process (GO:0051156)2.57970210
80endothelial cell chemotaxis (GO:0035767)2.57721681
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57672461
82apoptotic process involved in morphogenesis (GO:0060561)2.57375344
83regulation of clathrin-mediated endocytosis (GO:2000369)2.57297020
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.55898084
85regulation of synapse structural plasticity (GO:0051823)2.55423563
86pentose-phosphate shunt (GO:0006098)2.55121392
87negative regulation of catenin import into nucleus (GO:0035414)2.54611056
88positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54516729
89negative regulation of viral release from host cell (GO:1902187)2.53332518
90response to laminar fluid shear stress (GO:0034616)2.52920013
91establishment or maintenance of monopolar cell polarity (GO:0061339)2.52740343
92establishment of monopolar cell polarity (GO:0061162)2.52740343
93proline transport (GO:0015824)2.51633962
94glucocorticoid receptor signaling pathway (GO:0042921)2.51621294
95NLS-bearing protein import into nucleus (GO:0006607)2.49949331
96cell-substrate junction assembly (GO:0007044)2.48716994
97glucose catabolic process (GO:0006007)2.47434632
983-UTR-mediated mRNA stabilization (GO:0070935)2.45978395
99negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.45882483
100modulation by virus of host morphology or physiology (GO:0019048)2.45062087
101dendritic spine morphogenesis (GO:0060997)2.44852183
102regulation of chromatin binding (GO:0035561)2.44821476
103glutamate secretion (GO:0014047)2.43730062
104negative regulation of glial cell proliferation (GO:0060253)2.42190027
105apoptotic process involved in development (GO:1902742)2.41991418
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.41695948
107endocytic recycling (GO:0032456)2.40671286
108regulation of apoptotic process involved in morphogenesis (GO:1902337)2.39852966
109embryonic process involved in female pregnancy (GO:0060136)2.39678807
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39367363
111convergent extension (GO:0060026)2.38687666
112positive regulation of glycogen biosynthetic process (GO:0045725)2.38609531
113activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38429512
114positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.36567703
115modulation by virus of host process (GO:0019054)2.36338105
116cortical actin cytoskeleton organization (GO:0030866)2.36320712
117branching involved in mammary gland duct morphogenesis (GO:0060444)2.36045569
118mitotic G1 DNA damage checkpoint (GO:0031571)2.35874762
119stress granule assembly (GO:0034063)2.35085043
120positive regulation of protein deacetylation (GO:0090312)2.34919640
121glial cell proliferation (GO:0014009)2.34528386
122regulation of fatty acid beta-oxidation (GO:0031998)2.34406609
123vocalization behavior (GO:0071625)2.33515769
124receptor catabolic process (GO:0032801)2.32998432
125cell volume homeostasis (GO:0006884)2.31088028
126negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30165889
127endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.29984564
128cell-cell junction maintenance (GO:0045217)2.29781442
129protein heterotrimerization (GO:0070208)2.28477783
130positive regulation of gene expression, epigenetic (GO:0045815)2.28123660
131cell communication involved in cardiac conduction (GO:0086065)2.27506743
132negative regulation of heart growth (GO:0061117)2.27403186
133negative regulation of cardiac muscle tissue growth (GO:0055022)2.27403186
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.27247554
135cellular potassium ion homeostasis (GO:0030007)2.27243093
136positive regulation of nuclease activity (GO:0032075)2.26697072
137epithelial cell-cell adhesion (GO:0090136)2.25965801
138activation of JUN kinase activity (GO:0007257)2.25782883
139positive regulation of myotube differentiation (GO:0010831)2.24423706
140cell junction maintenance (GO:0034331)2.24221766
141vascular endothelial growth factor signaling pathway (GO:0038084)2.23828655
142positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.23242489
143cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.22686747
144ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.22570643
145apoptotic cell clearance (GO:0043277)2.22452651
146regulation of p38MAPK cascade (GO:1900744)2.22356434
147regulation of cholesterol biosynthetic process (GO:0045540)2.22253883
148embryonic foregut morphogenesis (GO:0048617)2.21966558
149positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.21238412
150neural tube development (GO:0021915)2.21191099
151glycine transport (GO:0015816)2.19401757
152cardiac myofibril assembly (GO:0055003)2.19238851
153epithelial cell differentiation involved in prostate gland development (GO:0060742)2.18986477
154growth hormone secretion (GO:0030252)2.18805882
155spliceosomal tri-snRNP complex assembly (GO:0000244)2.18638534
156positive regulation of Rap GTPase activity (GO:0032854)2.18239303
157regulation of nucleobase-containing compound transport (GO:0032239)2.18127956
158regulation of tight junction assembly (GO:2000810)2.17719119
159actin filament bundle organization (GO:0061572)2.15632497
160actin filament bundle assembly (GO:0051017)2.15632497
161regulation of polysaccharide biosynthetic process (GO:0032885)2.13691859
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13120783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.24688201
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97016798
3MYC_22102868_ChIP-Seq_BL_Human2.92472282
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.86080697
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.78764957
6KDM2B_26808549_Chip-Seq_DND41_Human2.72184581
7LXR_22292898_ChIP-Seq_THP-1_Human2.57313777
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51547395
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.42099395
10KDM2B_26808549_Chip-Seq_K562_Human2.38489754
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.31163812
12ZFP281_27345836_Chip-Seq_ESCs_Mouse2.30439381
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.25096763
14TCF7_22412390_ChIP-Seq_EML_Mouse2.24785688
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22270850
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.16409961
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.14622508
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08125539
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.03405197
20VDR_21846776_ChIP-Seq_THP-1_Human2.03181293
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.98793203
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.96678061
23EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.93203486
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89864256
25RACK7_27058665_Chip-Seq_MCF-7_Human1.87936071
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81959808
27ZNF263_19887448_ChIP-Seq_K562_Human1.78601289
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78304420
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.77236652
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76371375
31P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75555252
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.71202458
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69893120
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65877423
35CREB1_26743006_Chip-Seq_LNCaP_Human1.64301575
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.62915927
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.60034893
38* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54456262
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53083794
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51659385
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51279217
42P68_20966046_ChIP-Seq_HELA_Human1.50077900
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48398938
44DROSHA_22980978_ChIP-Seq_HELA_Human1.48294877
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.46642051
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43800085
47* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43681408
48VDR_24763502_ChIP-Seq_THP-1_Human1.43369377
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42615200
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42523170
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40055384
52TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.38654134
53SMC4_20622854_ChIP-Seq_HELA_Human1.36574330
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.35865755
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35513222
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30534193
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30484981
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27735235
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27512898
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27356443
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27263508
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25871920
63TP53_22127205_ChIP-Seq_IMR90_Human1.25596811
64* ATF3_27146783_Chip-Seq_COLON_Human1.25259497
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22455170
66* ELF1_20517297_ChIP-Seq_JURKAT_Human1.20961280
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.20662813
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20616692
69CTCF_27219007_Chip-Seq_Bcells_Human1.19719985
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19565902
71* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18524174
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16758827
73NCOR1_26117541_ChIP-Seq_K562_Human1.16377704
74UTX_26944678_Chip-Seq_JUKART_Human1.14167375
75MAF_26560356_Chip-Seq_TH1_Human1.13271838
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13170722
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.11992504
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10466706
79MAF_26560356_Chip-Seq_TH2_Human1.10431909
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10367332
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09658173
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.08798834
83GATA1_19941826_ChIP-Seq_K562_Human1.08240264
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.08042556
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06186832
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.05349318
87TP63_22573176_ChIP-Seq_HFKS_Human1.05018664
88TP53_23651856_ChIP-Seq_MEFs_Mouse1.04922190
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03103822
90NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02964337
91CLOCK_20551151_ChIP-Seq_293T_Human1.02830594
92TET1_21490601_ChIP-Seq_MESCs_Mouse1.02573394
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01979341
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01463521
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01267783
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00866436
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00792659
98HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98686523
99CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98672454
100SPI1_23127762_ChIP-Seq_K562_Human0.98143522
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97663056
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97598521
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97545418
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97346287
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96978433
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96515227
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96469796
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96348234
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96256155
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96064859
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96023762
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.95974153
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.95974153
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95885266
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95402262
116POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95024316
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.94824015
118* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94782459
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94608662
120* BCOR_27268052_Chip-Seq_Bcells_Human0.94489074
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94478341
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.94438709
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94370426
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93422041
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93240823
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92800323
127* OCT4_19829295_ChIP-Seq_ESCs_Human0.92564553
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.91066527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.82207165
2MP0004859_abnormal_synaptic_plasticity4.07549808
3MP0003283_abnormal_digestive_organ3.56134565
4MP0008961_abnormal_basal_metabolism3.01773898
5MP0005451_abnormal_body_composition2.85512939
6MP0005076_abnormal_cell_differentiation2.75697063
7MP0004858_abnormal_nervous_system2.75122468
8MP0002653_abnormal_ependyma_morphology2.47226859
9MP0005058_abnormal_lysosome_morphology2.40184660
10MP0010352_gastrointestinal_tract_polyps2.37821735
11MP0005623_abnormal_meninges_morphology2.34900265
12MP0009278_abnormal_bone_marrow2.32458472
13MP0002249_abnormal_larynx_morphology2.12854927
14MP0004233_abnormal_muscle_weight2.08294483
15MP0001849_ear_inflammation2.04522310
16MP0003453_abnormal_keratinocyte_physiol2.03705642
17MP0000751_myopathy1.98457303
18MP0005257_abnormal_intraocular_pressure1.98171371
19MP0000678_abnormal_parathyroid_gland1.93663983
20MP0008260_abnormal_autophagy1.89326315
21MP0009780_abnormal_chondrocyte_physiolo1.87560496
22MP0005409_darkened_coat_color1.85455977
23MP0009840_abnormal_foam_cell1.84919063
24MP0002909_abnormal_adrenal_gland1.75096339
25MP0003566_abnormal_cell_adhesion1.72540390
26MP0003300_gastrointestinal_ulcer1.70568165
27MP0010234_abnormal_vibrissa_follicle1.69960050
28MP0010030_abnormal_orbit_morphology1.68314393
29MP0001958_emphysema1.55774952
30MP0003635_abnormal_synaptic_transmissio1.55285998
31MP0002796_impaired_skin_barrier1.54768814
32MP0000733_abnormal_muscle_development1.53989012
33MP0000003_abnormal_adipose_tissue1.48751558
34MP0004087_abnormal_muscle_fiber1.46685398
35MP0003119_abnormal_digestive_system1.45611586
36MP0003191_abnormal_cellular_cholesterol1.43945113
37MP0001348_abnormal_lacrimal_gland1.42401303
38MP0003122_maternal_imprinting1.39491734
39MP0004185_abnormal_adipocyte_glucose1.39375462
40MP0002060_abnormal_skin_morphology1.37640297
41MP0002877_abnormal_melanocyte_morpholog1.37088247
42MP0000858_altered_metastatic_potential1.34150040
43MP0000566_synostosis1.34060946
44MP0002089_abnormal_postnatal_growth/wei1.32980948
45MP0004130_abnormal_muscle_cell1.32035111
46MP0002269_muscular_atrophy1.31754547
47MP0004947_skin_inflammation1.30999840
48MP0010630_abnormal_cardiac_muscle1.27874434
49MP0003329_amyloid_beta_deposits1.26931434
50MP0003045_fibrosis1.24429072
51MP0005375_adipose_tissue_phenotype1.24005784
52MP0005501_abnormal_skin_physiology1.23346820
53MP0003115_abnormal_respiratory_system1.22242286
54MP0000767_abnormal_smooth_muscle1.21294449
55MP0004811_abnormal_neuron_physiology1.19565222
56MP0002063_abnormal_learning/memory/cond1.19192934
57MP0000537_abnormal_urethra_morphology1.19074104
58MP0003436_decreased_susceptibility_to1.18810242
59MP0004197_abnormal_fetal_growth/weight/1.18596884
60MP0003303_peritoneal_inflammation1.18438360
61MP0008770_decreased_survivor_rate1.17863023
62MP0002084_abnormal_developmental_patter1.17416914
63MP0000534_abnormal_ureter_morphology1.16744134
64MP0003091_abnormal_cell_migration1.16124727
65MP0002234_abnormal_pharynx_morphology1.13674139
66MP0004084_abnormal_cardiac_muscle1.13569021
67MP0003172_abnormal_lysosome_physiology1.13045525
68MP0008438_abnormal_cutaneous_collagen1.11990119
69MP0000747_muscle_weakness1.09285668
70MP0000569_abnormal_digit_pigmentation1.08585863
71MP0000759_abnormal_skeletal_muscle1.08333640
72MP0002925_abnormal_cardiovascular_devel1.07716645
73MP0004885_abnormal_endolymph1.07361945
74MP0003279_aneurysm1.03776804
75MP0005621_abnormal_cell_physiology1.02516983
76MP0002086_abnormal_extraembryonic_tissu1.02217853
77MP0005666_abnormal_adipose_tissue1.01190572
78MP0000579_abnormal_nail_morphology1.00403260
79MP0000955_abnormal_spinal_cord0.99022746
80MP0000013_abnormal_adipose_tissue0.98555988
81MP0009053_abnormal_anal_canal0.98325936
82MP0003634_abnormal_glial_cell0.98319609
83MP0001545_abnormal_hematopoietic_system0.96511270
84MP0005397_hematopoietic_system_phenotyp0.96511270
85MP0002896_abnormal_bone_mineralization0.96398297
86MP0005330_cardiomyopathy0.96268483
87MP0002837_dystrophic_cardiac_calcinosis0.95976471
88MP0000428_abnormal_craniofacial_morphol0.95506201
89MP0003075_altered_response_to0.94737289
90MP0002085_abnormal_embryonic_tissue0.94718034
91MP0000467_abnormal_esophagus_morphology0.94611872
92MP0000266_abnormal_heart_morphology0.93963935
93MP0000750_abnormal_muscle_regeneration0.93840551
94MP0002998_abnormal_bone_remodeling0.93503183
95MP0005508_abnormal_skeleton_morphology0.92636253
96MP0002254_reproductive_system_inflammat0.92071494
97MP0008569_lethality_at_weaning0.91234084
98MP0001730_embryonic_growth_arrest0.90997650
99MP0003137_abnormal_impulse_conducting0.90560482
100MP0003123_paternal_imprinting0.89678162
101MP0004270_analgesia0.89446286
102MP0003984_embryonic_growth_retardation0.89218864
103MP0002088_abnormal_embryonic_growth/wei0.88684477
104MP0005023_abnormal_wound_healing0.87536658
105MP0005380_embryogenesis_phenotype0.86617837
106MP0001672_abnormal_embryogenesis/_devel0.86617837
107MP0003385_abnormal_body_wall0.86154657
108MP0004510_myositis0.86100945
109MP0005670_abnormal_white_adipose0.84014767
110MP0001346_abnormal_lacrimal_gland0.83704910
111MP0004145_abnormal_muscle_electrophysio0.83654934
112MP0006138_congestive_heart_failure0.83060036
113MP0003861_abnormal_nervous_system0.81575226
114MP0003935_abnormal_craniofacial_develop0.81547516
115MP0004272_abnormal_basement_membrane0.80807827
116MP0002932_abnormal_joint_morphology0.80202680
117MP0005167_abnormal_blood-brain_barrier0.79690137
118MP0009931_abnormal_skin_appearance0.79300053
119MP0001216_abnormal_epidermal_layer0.79128188
120MP0002106_abnormal_muscle_physiology0.78796113
121MP0009384_cardiac_valve_regurgitation0.78392582
122MP0009672_abnormal_birth_weight0.78023919
123MP0000681_abnormal_thyroid_gland0.77451450
124MP0010307_abnormal_tumor_latency0.77307984
125MP0001697_abnormal_embryo_size0.77173517
126MP0000762_abnormal_tongue_morphology0.76421168
127MP0000604_amyloidosis0.75831879
128MP0004264_abnormal_extraembryonic_tissu0.74789282
129MP0005275_abnormal_skin_tensile0.71895825
130MP0002152_abnormal_brain_morphology0.70881051
131MP0005187_abnormal_penis_morphology0.70635903
132MP0001915_intracranial_hemorrhage0.70377985
133MP0003942_abnormal_urinary_system0.70327059
134MP0002064_seizures0.70249644
135MP0009703_decreased_birth_body0.69902974
136MP0003879_abnormal_hair_cell0.69719079
137MP0005390_skeleton_phenotype0.69435667
138MP0004808_abnormal_hematopoietic_stem0.68715794
139MP0002098_abnormal_vibrissa_morphology0.67572985
140MP0003448_altered_tumor_morphology0.67171688
141MP0000462_abnormal_digestive_system0.66652788
142MP0009333_abnormal_splenocyte_physiolog0.65750256
143MP0008874_decreased_physiological_sensi0.64825157
144MP0002080_prenatal_lethality0.62882865
145MP0001614_abnormal_blood_vessel0.61686179
146MP0000350_abnormal_cell_proliferation0.59771402

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.81934182
2Abnormality of the lower motor neuron (HP:0002366)3.67007783
3Cerebral aneurysm (HP:0004944)3.59367046
4Broad face (HP:0000283)3.18983980
5Shallow orbits (HP:0000586)3.18196424
6Insomnia (HP:0100785)3.14656748
7Upper limb amyotrophy (HP:0009129)3.05408520
8Distal upper limb amyotrophy (HP:0007149)3.05408520
9Renal duplication (HP:0000075)2.94956083
10Protrusio acetabuli (HP:0003179)2.80775304
11Hand muscle atrophy (HP:0009130)2.75783389
12Elfin facies (HP:0004428)2.72176793
13Neoplasm of the heart (HP:0100544)2.70280727
14Annular pancreas (HP:0001734)2.62518750
15Disproportionate tall stature (HP:0001519)2.57233511
16Pointed chin (HP:0000307)2.55141368
17Stridor (HP:0010307)2.50704327
18Turricephaly (HP:0000262)2.50673965
19Long palpebral fissure (HP:0000637)2.49519303
20Astrocytoma (HP:0009592)2.49388520
21Abnormality of the astrocytes (HP:0100707)2.49388520
22Renovascular hypertension (HP:0100817)2.47561911
23Macroorchidism (HP:0000053)2.45438907
24Distal lower limb muscle weakness (HP:0009053)2.44924194
25Bladder diverticulum (HP:0000015)2.42504790
26Spinal rigidity (HP:0003306)2.41741341
27Vertebral compression fractures (HP:0002953)2.38319602
28Cervical subluxation (HP:0003308)2.35971730
29Achilles tendon contracture (HP:0001771)2.35573729
30Bowel diverticulosis (HP:0005222)2.35299514
31Lymphangioma (HP:0100764)2.33984137
32Ependymoma (HP:0002888)2.33714917
33Dysmetric saccades (HP:0000641)2.30229311
34Genu recurvatum (HP:0002816)2.29202142
35Mitral regurgitation (HP:0001653)2.25453187
36Increased connective tissue (HP:0009025)2.25303546
37Difficulty running (HP:0009046)2.24907473
38Overriding aorta (HP:0002623)2.24356928
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.22099880
40Cerebral inclusion bodies (HP:0100314)2.20468821
41Broad metatarsal (HP:0001783)2.19614590
42Aneurysm (HP:0002617)2.18692432
43Atrophic scars (HP:0001075)2.18388673
44Hypercortisolism (HP:0001578)2.17229023
45Ankyloglossia (HP:0010296)2.17079294
46Difficulty climbing stairs (HP:0003551)2.15776951
47Abnormality of the Achilles tendon (HP:0005109)2.15761408
48Thin bony cortex (HP:0002753)2.11162897
49Ulnar bowing (HP:0003031)2.09932708
50Enlarged penis (HP:0000040)2.07929634
51Mitral valve prolapse (HP:0001634)2.07869688
52Mildly elevated creatine phosphokinase (HP:0008180)2.03152962
53Lower limb amyotrophy (HP:0007210)2.03126185
54Short 4th metacarpal (HP:0010044)2.01534594
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01534594
56Blue sclerae (HP:0000592)2.00944598
57Biconcave vertebral bodies (HP:0004586)2.00357934
58Broad palm (HP:0001169)1.99056494
59Myokymia (HP:0002411)1.98968094
60Bundle branch block (HP:0011710)1.98726592
61Flat cornea (HP:0007720)1.98448402
62Dilatation of the ascending aorta (HP:0005111)1.95892662
63Hemiplegia (HP:0002301)1.95677402
64Premature rupture of membranes (HP:0001788)1.95484121
65Ankle contracture (HP:0006466)1.94430887
66Neurofibrillary tangles (HP:0002185)1.94298255
67Flat acetabular roof (HP:0003180)1.91456177
68Hyperparathyroidism (HP:0000843)1.90718142
69Wormian bones (HP:0002645)1.90035603
70Hallux valgus (HP:0001822)1.89366096
71Deviation of the hallux (HP:0010051)1.89277750
72Advanced eruption of teeth (HP:0006288)1.87913822
73Visual hallucinations (HP:0002367)1.85895330
74Abnormality of the distal phalanx of the thumb (HP:0009617)1.85768947
75Increased variability in muscle fiber diameter (HP:0003557)1.85595996
76Pseudobulbar signs (HP:0002200)1.85480191
77Axonal loss (HP:0003447)1.85232952
78Myopathic facies (HP:0002058)1.84974099
79Abnormality of oral frenula (HP:0000190)1.84678044
80Ventricular fibrillation (HP:0001663)1.83437285
81Nuclear cataract (HP:0100018)1.83047039
82Generalized amyotrophy (HP:0003700)1.82184876
83Thin ribs (HP:0000883)1.80982948
84Resting tremor (HP:0002322)1.80768788
85Supranuclear gaze palsy (HP:0000605)1.79869085
86Hemorrhage of the eye (HP:0011885)1.79743267
87Abnormality of the 4th metacarpal (HP:0010012)1.79683149
88Fibroma (HP:0010614)1.79390241
89Easy fatigability (HP:0003388)1.79365265
90Patellar dislocation (HP:0002999)1.78606012
91Short nail (HP:0001799)1.76651229
92Heterotopia (HP:0002282)1.75374834
93EMG: neuropathic changes (HP:0003445)1.74841898
94Abnormality of the thoracic spine (HP:0100711)1.72693452
95Abnormality of the distal phalanges of the toes (HP:0010182)1.72508692
96J-shaped sella turcica (HP:0002680)1.72441504
97Elbow flexion contracture (HP:0002987)1.72166591
98Rapidly progressive (HP:0003678)1.71678088
99Arterial tortuosity (HP:0005116)1.71111258
100Premature skin wrinkling (HP:0100678)1.71094504
101Vascular tortuosity (HP:0004948)1.71000066
102Cholecystitis (HP:0001082)1.70069060
103Abnormal gallbladder physiology (HP:0012438)1.70069060
104Reticulocytosis (HP:0001923)1.69825764
105Distal lower limb amyotrophy (HP:0008944)1.69650660
106Cellulitis (HP:0100658)1.69399877
107Broad distal phalanx of finger (HP:0009836)1.68944731
108Hyporeflexia of lower limbs (HP:0002600)1.68449422
109Trismus (HP:0000211)1.67927644
110Sudden death (HP:0001699)1.67812653
111Broad thumb (HP:0011304)1.67104803
112Natal tooth (HP:0000695)1.66664596
113Fibrous tissue neoplasm (HP:0012316)1.66481185
114Increased nuchal translucency (HP:0010880)1.66461374
115Joint laxity (HP:0001388)1.65707784
116Dislocated radial head (HP:0003083)1.65600980
117Polygenic inheritance (HP:0010982)1.64593799
118Obstructive sleep apnea (HP:0002870)1.63761736
119Polycythemia (HP:0001901)1.63500997
120Long toe (HP:0010511)1.62687325
121Hypoventilation (HP:0002791)1.62194860
122Hamartoma of the eye (HP:0010568)1.61989484
123Hyperextensible skin (HP:0000974)1.61541687
124Round ear (HP:0100830)1.60562578
125Selective tooth agenesis (HP:0001592)1.60160221
126Ankle clonus (HP:0011448)1.59371869
127Striae distensae (HP:0001065)1.58888253
128Increased density of long bones (HP:0006392)1.58722744
129Bronchomalacia (HP:0002780)1.58527112
130Neuronal loss in central nervous system (HP:0002529)1.58449967
131Acanthosis nigricans (HP:0000956)1.57584778
132Genetic anticipation (HP:0003743)1.57553799
133Depression (HP:0000716)1.57531058
134Abnormality of skeletal muscle fiber size (HP:0012084)1.57423838
135Short 5th finger (HP:0009237)1.57309791
136Amyotrophic lateral sclerosis (HP:0007354)1.57129435
137Arnold-Chiari malformation (HP:0002308)1.56687926
138Megalocornea (HP:0000485)1.56357822
139Urethral obstruction (HP:0000796)1.56138925
140Impaired social interactions (HP:0000735)1.56060099
141Abnormal social behavior (HP:0012433)1.56060099
142Type 1 muscle fiber predominance (HP:0003803)1.54762544
143Precocious puberty (HP:0000826)1.54363507
144Asymmetric septal hypertrophy (HP:0001670)1.54019637
145Congenital hip dislocation (HP:0001374)1.53861939
146Abnormality of the radial head (HP:0003995)1.53853061
147Bowed forearm bones (HP:0003956)1.52937647
148Bowing of the arm (HP:0006488)1.52937647
149Fragile skin (HP:0001030)1.52919481
150Focal seizures (HP:0007359)1.52668992
151Sacral dimple (HP:0000960)1.52021547
152Vertebral arch anomaly (HP:0008438)1.51315789
153Glioma (HP:0009733)1.50269017
154Abnormality of the aortic arch (HP:0012303)1.50045831
155Back pain (HP:0003418)1.49512979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.55087648
2SMG13.45077142
3PKN23.20744519
4MAP3K103.14513915
5PRPF4B3.11997158
6ICK2.88945856
7IRAK32.87986969
8EEF2K2.76009680
9CDK122.63338740
10EPHA22.37448768
11RIPK12.32027028
12ERN12.29959185
13MAP3K92.22079391
14PRKD32.16132153
15PDGFRA2.07576904
16TYRO32.01322893
17TAOK11.91564995
18LATS21.88624373
19SIK21.75599817
20BMX1.73048807
21DDR21.71317811
22PAK61.70210242
23ALK1.66653245
24TTN1.65501253
25SIK11.57115822
26MST1R1.51145221
27KSR21.49309871
28PTK61.46816292
29TESK11.35649265
30TAOK21.35243779
31CAMKK11.31962323
32NME21.31101245
33ARAF1.30921425
34MTOR1.23443245
35MAP3K131.22797696
36NEK11.20881121
37DAPK21.20721530
38CAMK1G1.19856525
39UHMK11.19668222
40STK381.13133785
41DMPK1.11304540
42MAP3K71.08312131
43NTRK11.08235449
44CAMK1D1.03541542
45MARK21.03096056
46PRKCH1.02599589
47MAP2K31.00347898
48LMTK20.97879320
49CDC42BPA0.97594270
50IRAK20.95946877
51RET0.95773011
52PTK20.93974523
53SCYL20.92384645
54PRKD20.91442222
55PAK40.90328040
56NTRK30.89109874
57KSR10.87776608
58MAP3K30.87675410
59NTRK20.87219258
60MINK10.83725763
61PAK20.82799337
62EPHB20.82222034
63PDPK10.80137022
64LATS10.80005062
65BRAF0.78910513
66PHKG10.76004031
67PHKG20.76004031
68MARK10.75890012
69DYRK1B0.74908165
70MAP3K110.73766426
71PRKG20.71158456
72DAPK10.69237559
73MET0.68900483
74MAP3K80.68705307
75TESK20.68683388
76PDGFRB0.67725078
77GRK60.67320304
78PAK30.66772400
79LRRK20.66414765
80IRAK40.65959461
81STK110.65140705
82EPHA40.65132805
83CDK60.63609538
84SIK30.63328105
85RIPK40.62748132
86RPS6KA20.62744812
87CAMK40.61937781
88HIPK20.59910331
89TBK10.58737633
90MAP3K40.58197663
91FGFR40.58075881
92MAP2K20.56181094
93PRKD10.55841923
94CDK50.55452137
95MOS0.54898601
96FGFR10.51600553
97AKT20.51529050
98ERBB20.51298760
99SGK30.51153545
100RPS6KA10.50697152
101MAP3K20.49689864
102MATK0.49313966
103CDK150.49084647
104NEK20.48668321
105MAP3K10.48346720
106CDK70.45739645
107PRKAA10.44895873
108CDK11A0.44737189
109CDK180.44541192
110EPHB10.43434704
111PIM20.41830893
112RPS6KA60.41064077
113WNK10.40695706
114MAP4K10.40315594
115CDK40.40313386
116PDK10.39173624
117JAK20.38933530
118MAPK110.38840850
119MAP2K40.38532919
120CDK90.38302667
121RPS6KB20.38239130
122RPS6KC10.37813194
123RPS6KL10.37813194
124STK100.37352888
125RPS6KA30.37216683
126MAPK120.37059115
127MAPK100.36854242
128MAPK80.36678677
129CDK140.36356229
130MAP3K60.35426155
131TNK20.35334245
132ROCK20.34876287
133CAMK10.34447558
134ZAP700.30811107
135DAPK30.29796467

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95533926
2Nitrogen metabolism_Homo sapiens_hsa009101.90740077
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90081855
4mTOR signaling pathway_Homo sapiens_hsa041501.82556604
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78205023
6Other glycan degradation_Homo sapiens_hsa005111.76720241
7Prion diseases_Homo sapiens_hsa050201.69427444
8Chronic myeloid leukemia_Homo sapiens_hsa052201.56072691
9Glioma_Homo sapiens_hsa052141.50621851
10Notch signaling pathway_Homo sapiens_hsa043301.46318601
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43510276
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37803890
13Type II diabetes mellitus_Homo sapiens_hsa049301.36631643
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35167302
15Estrogen signaling pathway_Homo sapiens_hsa049151.33695588
16VEGF signaling pathway_Homo sapiens_hsa043701.30814512
17Lysine degradation_Homo sapiens_hsa003101.30278426
18Endometrial cancer_Homo sapiens_hsa052131.29636958
19Bladder cancer_Homo sapiens_hsa052191.28648914
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.28324979
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27867054
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.27301584
23Non-small cell lung cancer_Homo sapiens_hsa052231.27284305
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25565507
25Dilated cardiomyopathy_Homo sapiens_hsa054141.25038613
26Pentose phosphate pathway_Homo sapiens_hsa000301.22463345
27Proteoglycans in cancer_Homo sapiens_hsa052051.22268011
28Synaptic vesicle cycle_Homo sapiens_hsa047211.20767389
29Long-term potentiation_Homo sapiens_hsa047201.19759602
30Gastric acid secretion_Homo sapiens_hsa049711.16760794
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16503350
32Hippo signaling pathway_Homo sapiens_hsa043901.16488227
33GnRH signaling pathway_Homo sapiens_hsa049121.15914857
34B cell receptor signaling pathway_Homo sapiens_hsa046621.15336852
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15068085
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14019976
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13539844
38Basal cell carcinoma_Homo sapiens_hsa052171.13420915
39Focal adhesion_Homo sapiens_hsa045101.12917618
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12638432
41Dorso-ventral axis formation_Homo sapiens_hsa043201.12382561
42Olfactory transduction_Homo sapiens_hsa047401.11747713
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.11229767
44Gap junction_Homo sapiens_hsa045401.10397924
45Insulin signaling pathway_Homo sapiens_hsa049101.09865272
46Fructose and mannose metabolism_Homo sapiens_hsa000511.08659334
47ErbB signaling pathway_Homo sapiens_hsa040121.08401116
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07544533
49Adherens junction_Homo sapiens_hsa045201.06586653
50ECM-receptor interaction_Homo sapiens_hsa045121.06430230
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05976991
52Insulin resistance_Homo sapiens_hsa049311.05303222
53Insulin secretion_Homo sapiens_hsa049111.05073125
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04322215
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03549224
56Colorectal cancer_Homo sapiens_hsa052101.03207803
57Oxytocin signaling pathway_Homo sapiens_hsa049211.01941505
58Circadian entrainment_Homo sapiens_hsa047131.00103411
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98362619
60Hedgehog signaling pathway_Homo sapiens_hsa043400.97195538
61Melanogenesis_Homo sapiens_hsa049160.96929122
62Salivary secretion_Homo sapiens_hsa049700.96637275
63Renal cell carcinoma_Homo sapiens_hsa052110.96340723
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.96140353
65AMPK signaling pathway_Homo sapiens_hsa041520.94842064
66Acute myeloid leukemia_Homo sapiens_hsa052210.93597652
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.93427636
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92541932
69Prostate cancer_Homo sapiens_hsa052150.92198220
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91845618
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.90389644
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89725970
73Glucagon signaling pathway_Homo sapiens_hsa049220.89216441
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89109672
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88119565
76Dopaminergic synapse_Homo sapiens_hsa047280.87944591
77Galactose metabolism_Homo sapiens_hsa000520.87897288
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87430686
79Cholinergic synapse_Homo sapiens_hsa047250.86887702
80Bile secretion_Homo sapiens_hsa049760.86676797
81Pancreatic cancer_Homo sapiens_hsa052120.86561363
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86297122
83Vibrio cholerae infection_Homo sapiens_hsa051100.86114635
84Hepatitis C_Homo sapiens_hsa051600.85646603
85MicroRNAs in cancer_Homo sapiens_hsa052060.85256883
86GABAergic synapse_Homo sapiens_hsa047270.84549609
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84195887
88Osteoclast differentiation_Homo sapiens_hsa043800.84002420
89Hepatitis B_Homo sapiens_hsa051610.83848228
90Rap1 signaling pathway_Homo sapiens_hsa040150.83279519
91Endocytosis_Homo sapiens_hsa041440.83052901
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82700028
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.82458834
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82057805
95Amoebiasis_Homo sapiens_hsa051460.81944985
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81734080
97Apoptosis_Homo sapiens_hsa042100.81517405
98TNF signaling pathway_Homo sapiens_hsa046680.81437974
99Inositol phosphate metabolism_Homo sapiens_hsa005620.80936875
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80168276
101Glutamatergic synapse_Homo sapiens_hsa047240.78981571
102Biosynthesis of amino acids_Homo sapiens_hsa012300.78480248
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.78396449
104Salmonella infection_Homo sapiens_hsa051320.76945035
105Axon guidance_Homo sapiens_hsa043600.76601690
106MAPK signaling pathway_Homo sapiens_hsa040100.76457571
107Fatty acid biosynthesis_Homo sapiens_hsa000610.76069603
108Amphetamine addiction_Homo sapiens_hsa050310.76041662
109Choline metabolism in cancer_Homo sapiens_hsa052310.75828076
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74608996
111Shigellosis_Homo sapiens_hsa051310.74550773
112Wnt signaling pathway_Homo sapiens_hsa043100.73682695
113Small cell lung cancer_Homo sapiens_hsa052220.73250395
114Prolactin signaling pathway_Homo sapiens_hsa049170.73026981
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72772766
116cAMP signaling pathway_Homo sapiens_hsa040240.72557980
117HIF-1 signaling pathway_Homo sapiens_hsa040660.72033051
118Arginine biosynthesis_Homo sapiens_hsa002200.71870849
119Cocaine addiction_Homo sapiens_hsa050300.71747159
120Tight junction_Homo sapiens_hsa045300.71224302
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69753377
122HTLV-I infection_Homo sapiens_hsa051660.69600452
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69531520
124Toxoplasmosis_Homo sapiens_hsa051450.69380552
125Viral myocarditis_Homo sapiens_hsa054160.68556740
126Thyroid cancer_Homo sapiens_hsa052160.67817212
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67222988
128Renin secretion_Homo sapiens_hsa049240.66784618
129Lysosome_Homo sapiens_hsa041420.64525965
130Morphine addiction_Homo sapiens_hsa050320.63710909
131Platelet activation_Homo sapiens_hsa046110.63011570
132Vitamin B6 metabolism_Homo sapiens_hsa007500.62897380
133Influenza A_Homo sapiens_hsa051640.59419120
134Pathways in cancer_Homo sapiens_hsa052000.57039682
135Viral carcinogenesis_Homo sapiens_hsa052030.55897186
136Melanoma_Homo sapiens_hsa052180.54561639

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