SCAF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.08641223
2nuclear pore organization (GO:0006999)5.66223376
3protein localization to kinetochore (GO:0034501)5.50461665
4monoubiquitinated protein deubiquitination (GO:0035520)4.84737776
5mitotic sister chromatid cohesion (GO:0007064)4.79716677
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.75196222
7interkinetic nuclear migration (GO:0022027)4.72244835
8DNA unwinding involved in DNA replication (GO:0006268)4.60230203
9pore complex assembly (GO:0046931)4.58284365
10positive regulation of gamma-delta T cell activation (GO:0046645)4.52104125
11heterochromatin organization (GO:0070828)4.43193408
12pre-miRNA processing (GO:0031054)4.36280998
13protein localization to chromosome, centromeric region (GO:0071459)4.31112732
14regulation of B cell receptor signaling pathway (GO:0050855)4.27547121
15sister chromatid segregation (GO:0000819)4.24076048
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18805781
17mitotic chromosome condensation (GO:0007076)4.04835478
18mitotic sister chromatid segregation (GO:0000070)4.03641516
19hepatocyte apoptotic process (GO:0097284)4.01791317
20chromatin assembly (GO:0031497)4.00217506
21establishment of protein localization to Golgi (GO:0072600)3.86841836
22DNA duplex unwinding (GO:0032508)3.82300110
23DNA geometric change (GO:0032392)3.79692428
24RNA stabilization (GO:0043489)3.79027431
25mRNA stabilization (GO:0048255)3.79027431
26histone H3-K4 trimethylation (GO:0080182)3.75776819
27peptidyl-lysine trimethylation (GO:0018023)3.74676117
28histone H3-K9 methylation (GO:0051567)3.74260773
29mitotic nuclear envelope disassembly (GO:0007077)3.73520402
30negative T cell selection (GO:0043383)3.72564947
31cellular response to ethanol (GO:0071361)3.70935214
32negative regulation of histone methylation (GO:0031061)3.68183992
33regulation of RNA export from nucleus (GO:0046831)3.67027613
34DNA replication-dependent nucleosome assembly (GO:0006335)3.66814579
35DNA replication-dependent nucleosome organization (GO:0034723)3.66814579
36positive regulation of granulocyte differentiation (GO:0030854)3.63326675
37negative thymic T cell selection (GO:0045060)3.62526680
38histone H3-K9 modification (GO:0061647)3.54467431
39negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.53540176
40neural tube formation (GO:0001841)3.52455974
41membrane disassembly (GO:0030397)3.49552172
42nuclear envelope disassembly (GO:0051081)3.49552172
43regulation of histone H3-K9 methylation (GO:0051570)3.49237176
44regulation of establishment of cell polarity (GO:2000114)3.47527531
45protein targeting to Golgi (GO:0000042)3.44220960
46definitive hemopoiesis (GO:0060216)3.40317574
47retrograde transport, vesicle recycling within Golgi (GO:0000301)3.36613847
48regulation of gamma-delta T cell differentiation (GO:0045586)3.34798914
49regulation of telomere maintenance via telomerase (GO:0032210)3.32984474
50histone H3-K36 demethylation (GO:0070544)3.32616416
51regulation of gamma-delta T cell activation (GO:0046643)3.29437016
52negative regulation of cell cycle G2/M phase transition (GO:1902750)3.27253368
53histone-serine phosphorylation (GO:0035404)3.23282103
54B cell receptor signaling pathway (GO:0050853)3.19218501
55dosage compensation (GO:0007549)3.18707184
56protein K11-linked deubiquitination (GO:0035871)3.18444280
57regulation of DNA endoreduplication (GO:0032875)3.16682401
58IMP biosynthetic process (GO:0006188)3.13723150
59DNA replication checkpoint (GO:0000076)3.12774483
60folic acid-containing compound biosynthetic process (GO:0009396)3.11466951
61protein localization to chromosome (GO:0034502)3.11231298
62NLS-bearing protein import into nucleus (GO:0006607)3.10239155
63rRNA catabolic process (GO:0016075)3.08335939
64negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.07748072
65histone H4-K12 acetylation (GO:0043983)3.07448656
66DNA conformation change (GO:0071103)3.06153321
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06090703
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98813509
69necroptotic process (GO:0070266)2.98784516
70regulation of nuclear cell cycle DNA replication (GO:0033262)2.98188577
71protein K48-linked deubiquitination (GO:0071108)2.98166114
72regulation of spindle organization (GO:0090224)2.98162591
73chromatin assembly or disassembly (GO:0006333)2.96052008
74DNA replication initiation (GO:0006270)2.95945242
75kinetochore organization (GO:0051383)2.94803914
76positive regulation of B cell differentiation (GO:0045579)2.93556747
77positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93532659
78regulation of gene silencing by RNA (GO:0060966)2.91647259
79regulation of posttranscriptional gene silencing (GO:0060147)2.91647259
80regulation of gene silencing by miRNA (GO:0060964)2.91647259
81regulation of B cell differentiation (GO:0045577)2.90640134
82protein targeting to vacuole (GO:0006623)2.90254378
83protein targeting to lysosome (GO:0006622)2.90254378
84establishment of protein localization to vacuole (GO:0072666)2.90254378
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90017117
86regulation of establishment or maintenance of cell polarity (GO:0032878)2.89382433
87microtubule anchoring (GO:0034453)2.89366146
88regulation of MHC class I biosynthetic process (GO:0045343)2.89319484
89peptidyl-lysine methylation (GO:0018022)2.89319404
90regulation of mitotic spindle organization (GO:0060236)2.88754921
91positive regulation of histone deacetylation (GO:0031065)2.88688915
92mitotic metaphase plate congression (GO:0007080)2.87693768
93regulation of sister chromatid cohesion (GO:0007063)2.86559634
94positive regulation of developmental pigmentation (GO:0048087)2.84187220
95regulation of pigment cell differentiation (GO:0050932)2.84140350
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.83348930
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83348930
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83348930
99regulation of nucleobase-containing compound transport (GO:0032239)2.81824578
100regulation of fibroblast apoptotic process (GO:2000269)2.81263536
101histone H2A monoubiquitination (GO:0035518)2.80813535
102regulation of mRNA stability (GO:0043488)2.80662439
103positive T cell selection (GO:0043368)2.80589709
104trophectodermal cell differentiation (GO:0001829)2.80242743
105protein prenylation (GO:0018342)2.79766209
106prenylation (GO:0097354)2.79766209
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79520403
108glucocorticoid receptor signaling pathway (GO:0042921)2.79222054
109sister chromatid cohesion (GO:0007062)2.78340249
110histone H4-K8 acetylation (GO:0043982)2.78046543
111histone H4-K5 acetylation (GO:0043981)2.78046543
112positive regulation of chromosome segregation (GO:0051984)2.77325544
113attachment of spindle microtubules to kinetochore (GO:0008608)2.74928949
114replicative senescence (GO:0090399)2.73374162
115pericardium development (GO:0060039)2.73159324
1163-UTR-mediated mRNA stabilization (GO:0070935)2.72815871
117chromosome condensation (GO:0030261)2.71630720
118nuclear envelope organization (GO:0006998)2.71566294
119negative regulation of B cell proliferation (GO:0030889)2.71233134
120paraxial mesoderm development (GO:0048339)2.71143507
121response to interleukin-15 (GO:0070672)2.71055964
122necrotic cell death (GO:0070265)2.70877808
123regulation of translational fidelity (GO:0006450)2.70737752
124metaphase plate congression (GO:0051310)2.70156793
125mitotic G2/M transition checkpoint (GO:0044818)2.69267375
126regulation of centriole replication (GO:0046599)2.69219108
127mitotic G2 DNA damage checkpoint (GO:0007095)2.68660867
128replication fork processing (GO:0031297)2.68534377
129regulation of alpha-beta T cell proliferation (GO:0046640)2.68305857
130cellular extravasation (GO:0045123)2.67698650
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.66349059
132regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.65861428
133nucleus localization (GO:0051647)2.65334073
134histone mRNA catabolic process (GO:0071044)2.65164205
135IMP metabolic process (GO:0046040)2.63224748
136spindle assembly checkpoint (GO:0071173)2.62848279
137translesion synthesis (GO:0019985)2.62095470
138negative regulation of translation, ncRNA-mediated (GO:0040033)2.62088947
139regulation of translation, ncRNA-mediated (GO:0045974)2.62088947
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62088947
141regulation of gene silencing (GO:0060968)2.60881756
142histone H4-K16 acetylation (GO:0043984)2.60557332
143regulation of RNA stability (GO:0043487)2.60405456
144protein K63-linked deubiquitination (GO:0070536)2.60380981
145positive regulation of SMAD protein import into nucleus (GO:0060391)2.59923300
146spindle checkpoint (GO:0031577)2.59862179
147nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.59467200
148genitalia morphogenesis (GO:0035112)2.58839623
149regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.58531535
150somatic hypermutation of immunoglobulin genes (GO:0016446)2.58484765
151somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58484765
152alternative mRNA splicing, via spliceosome (GO:0000380)2.58389038
153DNA topological change (GO:0006265)2.57614001
154centriole replication (GO:0007099)2.57265700
155negative regulation of fibroblast apoptotic process (GO:2000270)2.56473410
156positive regulation of mRNA catabolic process (GO:0061014)2.56066008
157regulation of chromosome segregation (GO:0051983)2.54972584
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.54782315
159negative regulation of DNA repair (GO:0045738)2.54351172
160mitotic DNA integrity checkpoint (GO:0044774)2.54068014
161early endosome to late endosome transport (GO:0045022)2.54007792
162DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.53371589
163microglial cell activation (GO:0001774)2.53047987
164chromosome segregation (GO:0007059)2.52830175
165programmed necrotic cell death (GO:0097300)2.52038399
166mRNA transport (GO:0051028)2.51841545
167gene silencing by RNA (GO:0031047)2.51440253
168regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51371938
169peptidyl-lysine dimethylation (GO:0018027)2.51299753
170interferon-gamma production (GO:0032609)2.51074881
171cellular response to interleukin-15 (GO:0071350)2.50890763
172formation of translation preinitiation complex (GO:0001731)2.50781029
173response to UV-C (GO:0010225)2.50582206
174cytoplasmic mRNA processing body assembly (GO:0033962)2.50530494
175DNA packaging (GO:0006323)2.50253284
176regulation of DNA-dependent DNA replication (GO:0090329)2.49869950
177negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49299886
178positive regulation of interferon-alpha production (GO:0032727)2.49202268
179interleukin-6-mediated signaling pathway (GO:0070102)2.48348118
180regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48267030
181detection of molecule of bacterial origin (GO:0032490)2.43830413
182negative regulation of T cell mediated immunity (GO:0002710)2.41671832
183phospholipid translocation (GO:0045332)2.41534751
184lipid translocation (GO:0034204)2.41534751
185double-strand break repair via homologous recombination (GO:0000724)2.41223176
186antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.40189450
187dendritic cell migration (GO:0036336)2.39409968
188positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.38294784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.69635783
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.20098714
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95878183
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.81896736
5GATA1_22025678_ChIP-Seq_K562_Human3.10703700
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10204530
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90445351
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.87761106
9MYC_22102868_ChIP-Seq_BL_Human2.79940155
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.78480930
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67570511
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63063548
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.59659194
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57138814
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.51793721
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45692349
17AR_21909140_ChIP-Seq_LNCAP_Human2.42215643
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.34621685
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.34621685
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.34621685
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.16781656
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.09626692
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.01136620
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99026748
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96033744
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95575845
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94554346
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91574510
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91435234
30EWS_26573619_Chip-Seq_HEK293_Human1.89661028
31FUS_26573619_Chip-Seq_HEK293_Human1.83960725
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81275173
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77680157
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72894784
35TAF15_26573619_Chip-Seq_HEK293_Human1.71609463
36RUNX_20019798_ChIP-Seq_JUKART_Human1.67632822
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67562589
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67259766
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65736300
40ER_23166858_ChIP-Seq_MCF-7_Human1.63615260
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62427109
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.60632342
43VDR_22108803_ChIP-Seq_LS180_Human1.59584718
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59086146
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58540532
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.55664957
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55413071
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54165369
49CIITA_25753668_ChIP-Seq_RAJI_Human1.53268292
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52828388
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51863840
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48950211
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46776669
54FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46149090
55TCF7_22412390_ChIP-Seq_EML_Mouse1.42959728
56IGF1R_20145208_ChIP-Seq_DFB_Human1.42324736
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42011670
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40878316
59ZNF274_21170338_ChIP-Seq_K562_Hela1.40768132
60P300_19829295_ChIP-Seq_ESCs_Human1.40544704
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40101222
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39655756
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38075685
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37329061
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37163791
66STAT3_23295773_ChIP-Seq_U87_Human1.35449705
67VDR_21846776_ChIP-Seq_THP-1_Human1.34570509
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.34566125
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.34392036
70KDM5A_27292631_Chip-Seq_BREAST_Human1.34018561
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.33900340
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33769476
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33275077
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.32920756
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31340003
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30321694
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29719062
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28484796
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27911160
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27854599
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.26185276
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25599447
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.24907605
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24842220
85TFEB_21752829_ChIP-Seq_HELA_Human1.23412344
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22947396
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22693254
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22544420
89XRN2_22483619_ChIP-Seq_HELA_Human1.22398137
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22001347
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21515971
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21244989
93BCAT_22108803_ChIP-Seq_LS180_Human1.20525367
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.20116828
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19687837
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19635067
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18887807
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18413188
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18173871
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17785668
101TCF4_23295773_ChIP-Seq_U87_Human1.17765489
102TP53_16413492_ChIP-PET_HCT116_Human1.17631929
103GBX2_23144817_ChIP-Seq_PC3_Human1.17475298
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17360446
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17244758
106GATA3_26560356_Chip-Seq_TH2_Human1.17209511
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16842868
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.16827310
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16666988
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16011700
111SMAD4_21799915_ChIP-Seq_A2780_Human1.15825053
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15821482
113CHD1_26751641_Chip-Seq_LNCaP_Human1.15260595
114GATA3_27048872_Chip-Seq_THYMUS_Human1.15104535
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14987975
116ELK1_19687146_ChIP-ChIP_HELA_Human1.14267405
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14135000
118CDX2_22108803_ChIP-Seq_LS180_Human1.14096698
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13945321
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.13917833
121P53_22387025_ChIP-Seq_ESCs_Mouse1.13678913
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12884925
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12088403
124NCOR1_26117541_ChIP-Seq_K562_Human1.11783573
125BRD4_25478319_ChIP-Seq_HGPS_Human1.11180697
126CBP_20019798_ChIP-Seq_JUKART_Human1.09647146
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09647146
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.09151397
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09048290
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08942601
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08805858
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08422949
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08271261
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07809747
135UTX_26944678_Chip-Seq_JUKART_Human1.07566166
136FOXP3_21729870_ChIP-Seq_TREG_Human1.07065275
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06089675
138PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06037500
139MYB_26560356_Chip-Seq_TH1_Human1.05991009
140CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05571056
141ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04951614
142P300_18555785_Chip-Seq_ESCs_Mouse1.04765995
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04453309
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04297791
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.04088575
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03604538
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03573213
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03209329
149SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03166644
150SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02598939
151VDR_23849224_ChIP-Seq_CD4+_Human1.02325098
152FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02306630
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01920153
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01879591
155NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01879591
156OCT4_18555785_Chip-Seq_ESCs_Mouse1.01787203
157ESR1_20079471_ChIP-ChIP_T-47D_Human1.00848344
158BP1_19119308_ChIP-ChIP_Hs578T_Human1.00518702
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99427686
160MAF_26560356_Chip-Seq_TH1_Human0.97526212
161SCL_19346495_ChIP-Seq_HPC-7_Human0.97307150
162NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97200159
163TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96695105
164ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96182415
165STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95647333
166SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94512116
167TTF2_22483619_ChIP-Seq_HELA_Human0.93786137
168HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93355677
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93274604
170ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92199834
171KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91336945
172KDM2B_26808549_Chip-Seq_DND41_Human0.90838589
173MYB_26560356_Chip-Seq_TH2_Human0.90260711
174SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90214851
175TP63_17297297_ChIP-ChIP_HaCaT_Human0.89831893
176TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88199546
177DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87980456
178SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87613370
179BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87572875
180GATA6_25053715_ChIP-Seq_YYC3_Human0.86997868
181EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86789138
182TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86597144
183SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85774738
184EST1_17652178_ChIP-ChIP_JURKAT_Human0.85693427
185ELK3_25401928_ChIP-Seq_HUVEC_Human0.85455220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.62841329
2MP0010352_gastrointestinal_tract_polyps3.30881717
3MP0003705_abnormal_hypodermis_morpholog2.95519880
4MP0008057_abnormal_DNA_replication2.94028862
5MP0004957_abnormal_blastocyst_morpholog2.85041385
6MP0010094_abnormal_chromosome_stability2.79362442
7MP0001835_abnormal_antigen_presentation2.79027272
8MP0003763_abnormal_thymus_physiology2.64909075
9MP0003077_abnormal_cell_cycle2.54404723
10MP0003111_abnormal_nucleus_morphology2.47200086
11MP0003693_abnormal_embryo_hatching2.36261710
12MP0005174_abnormal_tail_pigmentation2.28043495
13MP0005076_abnormal_cell_differentiation2.25003042
14MP0003890_abnormal_embryonic-extraembry2.22035106
15MP0004264_abnormal_extraembryonic_tissu2.12434997
16MP0005075_abnormal_melanosome_morpholog2.04221919
17MP0001800_abnormal_humoral_immune2.04203987
18MP0000350_abnormal_cell_proliferation1.98050970
19MP0003121_genomic_imprinting1.97239549
20MP0002396_abnormal_hematopoietic_system1.95810761
21MP0010307_abnormal_tumor_latency1.94915503
22MP0005380_embryogenesis_phenotype1.94461043
23MP0001672_abnormal_embryogenesis/_devel1.94461043
24MP0001730_embryonic_growth_arrest1.90497048
25MP0003984_embryonic_growth_retardation1.89484027
26MP0003123_paternal_imprinting1.89095390
27MP0002088_abnormal_embryonic_growth/wei1.88049572
28MP0004197_abnormal_fetal_growth/weight/1.78433731
29MP0002006_tumorigenesis1.77437930
30MP0002086_abnormal_extraembryonic_tissu1.71982915
31MP0004381_abnormal_hair_follicle1.70048618
32MP0000427_abnormal_hair_cycle1.69937933
33MP0002084_abnormal_developmental_patter1.67662811
34MP0003656_abnormal_erythrocyte_physiolo1.66673233
35MP0000685_abnormal_immune_system1.66280488
36MP0010030_abnormal_orbit_morphology1.65816514
37MP0008007_abnormal_cellular_replicative1.65222425
38MP0002877_abnormal_melanocyte_morpholog1.64863167
39MP0003724_increased_susceptibility_to1.64803497
40MP0002085_abnormal_embryonic_tissue1.58904975
41MP0000015_abnormal_ear_pigmentation1.58867534
42MP0004883_abnormal_blood_vessel1.54060711
43MP0004808_abnormal_hematopoietic_stem1.53390156
44MP0001697_abnormal_embryo_size1.53129391
45MP0001293_anophthalmia1.48856224
46MP0005671_abnormal_response_to1.48328823
47MP0002452_abnormal_antigen_presenting1.46238327
48MP0003566_abnormal_cell_adhesion1.41746375
49MP0000689_abnormal_spleen_morphology1.40490171
50MP0002723_abnormal_immune_serum1.37373638
51MP0002420_abnormal_adaptive_immunity1.37192742
52MP0000371_diluted_coat_color1.36798897
53MP0008932_abnormal_embryonic_tissue1.35853340
54MP0003252_abnormal_bile_duct1.35556802
55MP0001819_abnormal_immune_cell1.33731845
56MP0000428_abnormal_craniofacial_morphol1.33644096
57MP0003300_gastrointestinal_ulcer1.30997841
58MP0008058_abnormal_DNA_repair1.30603186
59MP0002080_prenatal_lethality1.30233793
60MP0005023_abnormal_wound_healing1.28604732
61MP0002092_abnormal_eye_morphology1.27688775
62MP0000733_abnormal_muscle_development1.27364926
63MP0000716_abnormal_immune_system1.25840879
64MP0009703_decreased_birth_body1.24860756
65MP0002405_respiratory_system_inflammati1.24192517
66MP0000465_gastrointestinal_hemorrhage1.23545914
67MP0003195_calcinosis1.23242794
68MP0003221_abnormal_cardiomyocyte_apopto1.21359231
69MP0006054_spinal_hemorrhage1.18644093
70MP0001849_ear_inflammation1.18641079
71MP0009697_abnormal_copulation1.18607055
72MP0005000_abnormal_immune_tolerance1.17001599
73MP0003122_maternal_imprinting1.16612145
74MP0003045_fibrosis1.15894352
75MP0003937_abnormal_limbs/digits/tail_de1.15553351
76MP0004147_increased_porphyrin_level1.15536090
77MP0002138_abnormal_hepatobiliary_system1.14865704
78MP0003935_abnormal_craniofacial_develop1.14740279
79MP0000490_abnormal_crypts_of1.13936422
80MP0003567_abnormal_fetal_cardiomyocyte1.12028984
81MP0002925_abnormal_cardiovascular_devel1.11274102
82MP0002419_abnormal_innate_immunity1.11175788
83MP0005387_immune_system_phenotype1.10730147
84MP0001790_abnormal_immune_system1.10730147
85MP0005408_hypopigmentation1.10561627
86MP0000432_abnormal_head_morphology1.10495892
87MP0009053_abnormal_anal_canal1.10262111
88MP0009672_abnormal_birth_weight1.07978410
89MP0003828_pulmonary_edema1.06757947
90MP0000313_abnormal_cell_death1.06114496
91MP0002168_other_aberrant_phenotype1.04424721
92MP0001915_intracranial_hemorrhage1.04033106
93MP0004484_altered_response_of1.01658101
94MP0002697_abnormal_eye_size1.01299908
95MP0002429_abnormal_blood_cell1.00330036
96MP0000383_abnormal_hair_follicle0.98738413
97MP0002019_abnormal_tumor_incidence0.98516948
98MP0008438_abnormal_cutaneous_collagen0.97453658
99MP0005257_abnormal_intraocular_pressure0.96395371
100MP0010234_abnormal_vibrissa_follicle0.93405374
101MP0010678_abnormal_skin_adnexa0.90512110
102MP0005310_abnormal_salivary_gland0.90092926
103MP0000537_abnormal_urethra_morphology0.90088860
104MP0003011_delayed_dark_adaptation0.89908352
105MP0003119_abnormal_digestive_system0.89325659
106MP0002932_abnormal_joint_morphology0.88692497
107MP0005164_abnormal_response_to0.88191150
108MP0000703_abnormal_thymus_morphology0.88101145
109MP0010155_abnormal_intestine_physiology0.87937141
110MP0006292_abnormal_olfactory_placode0.87851480
111MP0005025_abnormal_response_to0.86309086
112MP0003283_abnormal_digestive_organ0.85925978
113MP0009278_abnormal_bone_marrow0.85886041
114MP0009115_abnormal_fat_cell0.85677181
115MP0004084_abnormal_cardiac_muscle0.85507462
116MP0001873_stomach_inflammation0.85094921
117MP0003115_abnormal_respiratory_system0.84339255
118MP0001286_abnormal_eye_development0.83914899
119MP0005623_abnormal_meninges_morphology0.83574361
120MP0003091_abnormal_cell_migration0.83366712
121MP0002095_abnormal_skin_pigmentation0.83164815
122MP0002148_abnormal_hypersensitivity_rea0.82767704
123MP0002111_abnormal_tail_morphology0.82384892
124MP0001851_eye_inflammation0.82016647
125MP0008877_abnormal_DNA_methylation0.81250494
126MP0005248_abnormal_Harderian_gland0.79925142
127MP0008961_abnormal_basal_metabolism0.79534041
128MP0003755_abnormal_palate_morphology0.79001571
129MP0005621_abnormal_cell_physiology0.78680642
130MP0004272_abnormal_basement_membrane0.78336900
131MP0003943_abnormal_hepatobiliary_system0.77553249
132MP0000569_abnormal_digit_pigmentation0.76896950
133MP0001845_abnormal_inflammatory_respons0.75920420
134MP0009785_altered_susceptibility_to0.75828017
135MP0000266_abnormal_heart_morphology0.75134334
136MP0000377_abnormal_hair_follicle0.74953994
137MP0002928_abnormal_bile_duct0.73647999
138MP0003183_abnormal_peptide_metabolism0.72741731
139MP0005508_abnormal_skeleton_morphology0.72563482
140MP0005384_cellular_phenotype0.72179833
141MP0003172_abnormal_lysosome_physiology0.72133991
142MP0002398_abnormal_bone_marrow0.71756505
143MP0010630_abnormal_cardiac_muscle0.71708413
144MP0003646_muscle_fatigue0.71477431
145MP0003787_abnormal_imprinting0.71347771
146MP0002722_abnormal_immune_system0.71142160
147MP0001243_abnormal_dermal_layer0.71102660
148MP0002233_abnormal_nose_morphology0.70793726
149MP0002254_reproductive_system_inflammat0.70509555
150MP0000372_irregular_coat_pigmentation0.69049651
151MP0001545_abnormal_hematopoietic_system0.68597835
152MP0005397_hematopoietic_system_phenotyp0.68597835
153MP0005376_homeostasis/metabolism_phenot0.68137243
154MP0005464_abnormal_platelet_physiology0.67799574
155MP0002098_abnormal_vibrissa_morphology0.67496012
156MP0004145_abnormal_muscle_electrophysio0.67448157
157MP0002114_abnormal_axial_skeleton0.67001728
158MP0005395_other_phenotype0.66722516
159MP0000767_abnormal_smooth_muscle0.66323794
160MP0002166_altered_tumor_susceptibility0.66115961
161MP0004215_abnormal_myocardial_fiber0.64722848
162MP0002075_abnormal_coat/hair_pigmentati0.63812159
163MP0003786_premature_aging0.63070910

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.09573088
2T lymphocytopenia (HP:0005403)3.94646195
3Abnormality of T cell number (HP:0011839)3.70976500
4Ependymoma (HP:0002888)3.69749052
5Thyroiditis (HP:0100646)3.29474324
6Acute myeloid leukemia (HP:0004808)3.27502185
7Genetic anticipation (HP:0003743)3.14520895
8Abnormality of the astrocytes (HP:0100707)3.07225577
9Astrocytoma (HP:0009592)3.07225577
10Rhabdomyosarcoma (HP:0002859)2.91233246
11Neoplasm of striated muscle (HP:0009728)2.89895289
12Hypochromic microcytic anemia (HP:0004840)2.86288175
13Abnormality of the fingertips (HP:0001211)2.83600428
14Short 4th metacarpal (HP:0010044)2.83472274
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.83472274
16Medulloblastoma (HP:0002885)2.77181077
17Deviation of the thumb (HP:0009603)2.76089103
18Proximal placement of thumb (HP:0009623)2.74989928
19Increased nuchal translucency (HP:0010880)2.71382003
20Abnormal delayed hypersensitivity skin test (HP:0002963)2.71271800
21Panhypogammaglobulinemia (HP:0003139)2.69472402
22Chromsome breakage (HP:0040012)2.68165363
23Hepatoblastoma (HP:0002884)2.65753691
24Severe combined immunodeficiency (HP:0004430)2.61928166
25Glioma (HP:0009733)2.60511722
26Recurrent fungal infections (HP:0002841)2.59067366
27Fair hair (HP:0002286)2.58081493
28Chronic mucocutaneous candidiasis (HP:0002728)2.57261021
29Recurrent cutaneous fungal infections (HP:0011370)2.57261021
30Abnormality of T cells (HP:0002843)2.56961885
31Bilateral microphthalmos (HP:0007633)2.55951007
32Stomach cancer (HP:0012126)2.55222666
33Long eyelashes (HP:0000527)2.54128503
34Recurrent viral infections (HP:0004429)2.51426313
35Clubbing of toes (HP:0100760)2.51165384
36Abnormality of the renal cortex (HP:0011035)2.50497130
37Autoimmune hemolytic anemia (HP:0001890)2.47500039
38Rib fusion (HP:0000902)2.44982680
39Gaze-evoked nystagmus (HP:0000640)2.42780775
40Colon cancer (HP:0003003)2.40397026
41Macroorchidism (HP:0000053)2.39335001
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38526926
43Abnormality of B cell number (HP:0010975)2.36364454
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.33640205
45Abnormality of the distal phalanx of the thumb (HP:0009617)2.31966702
46Abnormality of the prostate (HP:0008775)2.30542712
47Prostate neoplasm (HP:0100787)2.28766838
48Recurrent bronchitis (HP:0002837)2.26558479
49Pancreatic cysts (HP:0001737)2.26518409
50Viral hepatitis (HP:0006562)2.25805993
51Ectopic kidney (HP:0000086)2.25364988
52Abnormality of eosinophils (HP:0001879)2.25331995
53Missing ribs (HP:0000921)2.22336669
54Hypoplasia of the thymus (HP:0000778)2.19602869
55Skin tags (HP:0010609)2.18823757
56Gastrointestinal carcinoma (HP:0002672)2.18167691
57Malignant gastrointestinal tract tumors (HP:0006749)2.18167691
58Thyroid carcinoma (HP:0002890)2.17900276
59Combined immunodeficiency (HP:0005387)2.14563834
60Renal cortical cysts (HP:0000803)2.14353622
61Selective tooth agenesis (HP:0001592)2.13809101
62Renal duplication (HP:0000075)2.13343753
63Broad thumb (HP:0011304)2.09792134
64Acute lymphatic leukemia (HP:0006721)2.09791926
65Generalized hypopigmentation of hair (HP:0011358)2.09681956
66Prominent nose (HP:0000448)2.09057518
67Atresia of the external auditory canal (HP:0000413)2.08311204
68Supernumerary ribs (HP:0005815)2.07406007
69Chronic hepatic failure (HP:0100626)2.07324863
70B lymphocytopenia (HP:0010976)2.06502896
71Chronic diarrhea (HP:0002028)2.06118089
72Abnormality of the 4th metacarpal (HP:0010012)2.05448739
73Ulnar bowing (HP:0003031)2.04114230
74Low anterior hairline (HP:0000294)2.03285055
75Preauricular skin tag (HP:0000384)2.03139148
76Neoplasm of the oral cavity (HP:0100649)2.02011774
77Urethral obstruction (HP:0000796)2.00699421
78Abnormality of T cell physiology (HP:0011840)2.00489854
79Neoplasm of the tracheobronchial system (HP:0100552)1.99708527
80Deep philtrum (HP:0002002)1.99147064
81IgM deficiency (HP:0002850)1.98535873
82Abnormality of the renal medulla (HP:0100957)1.98073306
83Central scotoma (HP:0000603)1.97688007
84Impulsivity (HP:0100710)1.97618514
85Hypoplastic iliac wings (HP:0002866)1.97171925
86Recurrent bacterial skin infections (HP:0005406)1.97086605
87Abnormality of macular pigmentation (HP:0008002)1.96921577
88Nephroblastoma (Wilms tumor) (HP:0002667)1.95210256
89Subacute progressive viral hepatitis (HP:0006572)1.94080389
90Eosinophilia (HP:0001880)1.94011491
91Pancreatic fibrosis (HP:0100732)1.93896600
92Short humerus (HP:0005792)1.93746821
93Abnormality of chromosome stability (HP:0003220)1.92963439
94Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90418001
95Widely spaced teeth (HP:0000687)1.90087859
96Spontaneous hematomas (HP:0007420)1.89672961
97IgA deficiency (HP:0002720)1.89347771
98Hypopigmentation of the fundus (HP:0007894)1.87327440
99Sloping forehead (HP:0000340)1.87136975
100Multiple enchondromatosis (HP:0005701)1.86629427
101Dislocated radial head (HP:0003083)1.86282355
102Abnormality of the preputium (HP:0100587)1.85719635
103Embryonal renal neoplasm (HP:0011794)1.85475289
104Hypoplastic labia majora (HP:0000059)1.85360094
105Constricted visual fields (HP:0001133)1.85356924
106Truncal obesity (HP:0001956)1.85314195
107Broad palm (HP:0001169)1.84287027
108Leukocytosis (HP:0001974)1.83505823
109Retrobulbar optic neuritis (HP:0100654)1.82997529
110Optic neuritis (HP:0100653)1.82997529
111Absent frontal sinuses (HP:0002688)1.82385341
112Narrow palate (HP:0000189)1.82377748
113Abnormal number of incisors (HP:0011064)1.82335506
114Curly hair (HP:0002212)1.81559162
115Aplasia/hypoplasia of the humerus (HP:0006507)1.81506165
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.81228048
117High pitched voice (HP:0001620)1.80682678
118Long clavicles (HP:0000890)1.80281382
119Abnormal lung lobation (HP:0002101)1.80274471
120Abnormality of the axillary hair (HP:0100134)1.80043028
121Abnormality of secondary sexual hair (HP:0009888)1.80043028
122Supernumerary bones of the axial skeleton (HP:0009144)1.79970922
123Aqueductal stenosis (HP:0002410)1.79935629
124Biliary tract neoplasm (HP:0100574)1.78647558
125Short 5th finger (HP:0009237)1.77892236
126Cystic hygroma (HP:0000476)1.77588566
127Large earlobe (HP:0009748)1.77469322
128Ankle contracture (HP:0006466)1.74586423
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74169965
130Dyschromatopsia (HP:0007641)1.73658809
131Abnormality of the radial head (HP:0003995)1.73321611
132Shallow orbits (HP:0000586)1.73286766
133Cerebral aneurysm (HP:0004944)1.73284438
134Cafe-au-lait spot (HP:0000957)1.72411618
135Abnormality of the phalanges of the hallux (HP:0010057)1.72013677
136Shawl scrotum (HP:0000049)1.71877623
137Cutis marmorata (HP:0000965)1.71844800
138Pseudobulbar signs (HP:0002200)1.71235031
139Neoplasm of the adrenal cortex (HP:0100641)1.70492017
140Broad phalanges of the hand (HP:0009768)1.70301857
141Facial diplegia (HP:0001349)1.70192042
142Myelodysplasia (HP:0002863)1.70146708
143Blepharitis (HP:0000498)1.69758826
144Sandal gap (HP:0001852)1.69682934
145Hematochezia (HP:0002573)1.69513227
146Mitral valve prolapse (HP:0001634)1.69426661
147Periodontitis (HP:0000704)1.68848182
148Abnormal biliary tract morphology (HP:0012440)1.68747124
149Uterine leiomyosarcoma (HP:0002891)1.68393593
150Leiomyosarcoma (HP:0100243)1.68393593
151Recurrent abscess formation (HP:0002722)1.68333189
152Encephalitis (HP:0002383)1.67073231
153Recurrent skin infections (HP:0001581)1.66906059
154Abnormality of the labia majora (HP:0012881)1.66718339
155Inflammation of the large intestine (HP:0002037)1.66086380
156Tubulointerstitial nephritis (HP:0001970)1.66043394
157Spinal cord lesions (HP:0100561)1.65867358
158Syringomyelia (HP:0003396)1.65867358
159Abnormality of the ileum (HP:0001549)1.65696570
160Mesomelia (HP:0003027)1.64726473
161Increased density of long bones (HP:0006392)1.64638253
162Protrusio acetabuli (HP:0003179)1.63746430
163Cutaneous melanoma (HP:0012056)1.63627218
164Meckel diverticulum (HP:0002245)1.63507696
165Limited elbow extension (HP:0001377)1.62124065
166Papillary thyroid carcinoma (HP:0002895)1.60866345
167Abnormality of chromosome segregation (HP:0002916)1.60214611
168Heterotopia (HP:0002282)1.60009788
169Uterine neoplasm (HP:0010784)1.59505901
170Basal cell carcinoma (HP:0002671)1.58041189
171Transitional cell carcinoma of the bladder (HP:0006740)1.57577572
172Duodenal stenosis (HP:0100867)1.56908870
173Small intestinal stenosis (HP:0012848)1.56908870
174Fused cervical vertebrae (HP:0002949)1.56725974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.31825679
2CDC73.58936565
3MAP3K102.74337810
4BMPR1B2.72582379
5EEF2K2.36051275
6STK102.28501270
7NEK22.27678502
8TTK2.10377077
9NLK2.08031649
10TAOK32.04151387
11LATS12.03680412
12PKN21.96734359
13ERN11.96032719
14TEC1.95838794
15PIK3CG1.73231094
16EIF2AK31.72937736
17BRD41.64308763
18PASK1.56619927
19RPS6KB21.53653182
20TRIB31.52904780
21CSF1R1.51526372
22WEE11.48213283
23CDK71.46866616
24STK391.46530315
25BMPR21.46456145
26STK38L1.46223288
27TGFBR21.46153423
28AKT31.44433489
29BLK1.43911621
30KIT1.43679623
31GRK61.43074931
32STK31.42439649
33OXSR11.41250181
34SCYL21.40833303
35CDK41.40322994
36CAMK1D1.37335129
37JAK11.36187871
38MTOR1.33813116
39TXK1.33750490
40PDGFRA1.33546056
41RPS6KA41.32882650
42ERBB31.31887966
43ATR1.29954949
44MAP3K141.26795094
45TYK21.25984426
46SRPK11.25176510
47TTN1.24016874
48* CHEK11.23659939
49ALK1.23171600
50CHEK21.21986440
51AURKB1.21067934
52IRAK11.19983768
53CDK61.19368989
54MKNK11.18783753
55TGFBR11.17244910
56PLK11.17044233
57FGFR31.17018592
58ACVR1B1.16757939
59CAMKK21.16523860
60RIPK41.13761169
61BTK1.10631286
62MAP4K11.09532574
63STK41.08403768
64PTK61.08367470
65PIK3CA1.08098593
66ATM1.06008579
67EPHA21.05718040
68IKBKE1.05642335
69LRRK21.05554202
70BRSK21.04593535
71PAK41.04281406
72TNIK1.01988036
73MAP3K80.99480460
74RIPK10.98750036
75MST40.94653360
76MELK0.92992635
77CDK20.89938410
78SGK20.86850488
79NEK10.84969915
80SYK0.84078106
81WNK30.83540141
82YES10.82508075
83PLK30.81344325
84SIK10.81120926
85FLT30.81077967
86MAP3K20.80800261
87WNK10.80588602
88HIPK20.79412113
89PIM10.77043289
90CAMK1G0.76692933
91MKNK20.74930735
92TSSK60.71170374
93HCK0.71066970
94PDGFRB0.69774767
95EIF2AK20.68647748
96FRK0.67941634
97BMX0.66899132
98ITK0.66520300
99MAP3K70.66499715
100CDK10.66092237
101PAK20.65248649
102CDK90.64955135
103FGFR10.64922490
104LYN0.64753460
105TYRO30.64413408
106LCK0.64328873
107STK240.62158012
108CHUK0.62134430
109JAK20.62128069
110IRAK40.61772004
111MAP3K60.59339512
112FER0.58225122
113PRKAA20.58157442
114PAK30.58018105
115BUB10.57555392
116CDK80.57352444
117MATK0.57271772
118EIF2AK10.55940026
119MAP2K30.55800363
120GRK10.55225371
121PLK40.54543101
122DMPK0.53841960
123ERBB20.53841644
124TRIM280.53660966
125MET0.52660047
126FGFR20.52123539
127MAPK70.52023956
128CSK0.51907062
129TRPM70.51581259
130MAPK140.51524687
131NUAK10.50930746
132FES0.50196746
133NEK90.49983059
134AKT20.49854321
135DYRK30.49810327
136JAK30.48057428
137NEK60.47904978
138MAPK10.46841748
139SGK30.46733260
140PTK20.45609498
141CSNK1D0.45235612
142OBSCN0.45153860
143PRKDC0.44427519
144ZAK0.44246721
145CLK10.44185607
146CSNK1E0.43893713
147PRKCQ0.42601240
148TNK20.42557049
149TLK10.42253337
150PLK20.42192885
151CAMK40.40744928
152DDR20.40435251
153AKT10.38282901
154RPS6KA50.33873370
155MARK30.33729952

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.00196932
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75840688
3Cell cycle_Homo sapiens_hsa041102.75006162
4Mismatch repair_Homo sapiens_hsa034302.70515376
5RNA transport_Homo sapiens_hsa030132.53302362
6One carbon pool by folate_Homo sapiens_hsa006702.30543053
7Spliceosome_Homo sapiens_hsa030402.25482243
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15103989
9Allograft rejection_Homo sapiens_hsa053302.15020500
10Base excision repair_Homo sapiens_hsa034101.95561179
11Graft-versus-host disease_Homo sapiens_hsa053321.94300237
12mRNA surveillance pathway_Homo sapiens_hsa030151.91416857
13Autoimmune thyroid disease_Homo sapiens_hsa053201.85091554
14Asthma_Homo sapiens_hsa053101.80015182
15MicroRNAs in cancer_Homo sapiens_hsa052061.78691281
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77508072
17Fanconi anemia pathway_Homo sapiens_hsa034601.71863685
18Non-homologous end-joining_Homo sapiens_hsa034501.68969127
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65641181
20Homologous recombination_Homo sapiens_hsa034401.64547766
21Small cell lung cancer_Homo sapiens_hsa052221.64202777
22Lysine degradation_Homo sapiens_hsa003101.63479444
23Dorso-ventral axis formation_Homo sapiens_hsa043201.61575967
24RNA degradation_Homo sapiens_hsa030181.58212115
25Systemic lupus erythematosus_Homo sapiens_hsa053221.54563026
26Viral carcinogenesis_Homo sapiens_hsa052031.53680084
27p53 signaling pathway_Homo sapiens_hsa041151.52812362
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50032467
29Nucleotide excision repair_Homo sapiens_hsa034201.48601802
30Adherens junction_Homo sapiens_hsa045201.46398280
31Type I diabetes mellitus_Homo sapiens_hsa049401.45045518
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43284697
33mTOR signaling pathway_Homo sapiens_hsa041501.33141515
34Chronic myeloid leukemia_Homo sapiens_hsa052201.32621859
35Staphylococcus aureus infection_Homo sapiens_hsa051501.32427362
36Thyroid cancer_Homo sapiens_hsa052161.30346860
37HTLV-I infection_Homo sapiens_hsa051661.29588577
38Herpes simplex infection_Homo sapiens_hsa051681.27175950
39Antigen processing and presentation_Homo sapiens_hsa046121.23779864
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22218501
41Proteoglycans in cancer_Homo sapiens_hsa052051.20863167
42Notch signaling pathway_Homo sapiens_hsa043301.15043685
43Tuberculosis_Homo sapiens_hsa051521.09841655
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08716515
45Basal cell carcinoma_Homo sapiens_hsa052171.08639029
46Selenocompound metabolism_Homo sapiens_hsa004501.08419210
47Osteoclast differentiation_Homo sapiens_hsa043801.06013943
48Prostate cancer_Homo sapiens_hsa052151.05898410
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05575336
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.04242025
51Propanoate metabolism_Homo sapiens_hsa006401.02742290
52Non-small cell lung cancer_Homo sapiens_hsa052231.00453308
53TGF-beta signaling pathway_Homo sapiens_hsa043500.99817496
54Hippo signaling pathway_Homo sapiens_hsa043900.99233440
55Pancreatic cancer_Homo sapiens_hsa052120.96012132
56Colorectal cancer_Homo sapiens_hsa052100.95830171
57B cell receptor signaling pathway_Homo sapiens_hsa046620.93206846
58Pathways in cancer_Homo sapiens_hsa052000.92615854
59Primary immunodeficiency_Homo sapiens_hsa053400.92257423
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.91624247
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91208068
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90698248
63Focal adhesion_Homo sapiens_hsa045100.90608726
64ABC transporters_Homo sapiens_hsa020100.89823972
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89486291
66Prolactin signaling pathway_Homo sapiens_hsa049170.89221304
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88689184
68Acute myeloid leukemia_Homo sapiens_hsa052210.85583950
69Hepatitis B_Homo sapiens_hsa051610.85166331
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.84061116
71Bladder cancer_Homo sapiens_hsa052190.83932017
72Viral myocarditis_Homo sapiens_hsa054160.83199182
73Epstein-Barr virus infection_Homo sapiens_hsa051690.82980784
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82144681
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81994538
76Apoptosis_Homo sapiens_hsa042100.81934583
77Malaria_Homo sapiens_hsa051440.78310601
78ECM-receptor interaction_Homo sapiens_hsa045120.78246543
79Hedgehog signaling pathway_Homo sapiens_hsa043400.74887038
80Endometrial cancer_Homo sapiens_hsa052130.73893988
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73312077
82Circadian rhythm_Homo sapiens_hsa047100.73057478
83Caffeine metabolism_Homo sapiens_hsa002320.73037200
84Ether lipid metabolism_Homo sapiens_hsa005650.71348641
85Nitrogen metabolism_Homo sapiens_hsa009100.71319641
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69422875
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69356250
88Basal transcription factors_Homo sapiens_hsa030220.68365077
89FoxO signaling pathway_Homo sapiens_hsa040680.66959488
90African trypanosomiasis_Homo sapiens_hsa051430.66766696
91Toxoplasmosis_Homo sapiens_hsa051450.65932824
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65719282
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63899334
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63730387
95Hepatitis C_Homo sapiens_hsa051600.63167402
96Chemokine signaling pathway_Homo sapiens_hsa040620.61619283
97Insulin resistance_Homo sapiens_hsa049310.60074210
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59988993
99Wnt signaling pathway_Homo sapiens_hsa043100.58672948
100Linoleic acid metabolism_Homo sapiens_hsa005910.58460485
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57385824
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57339385
103T cell receptor signaling pathway_Homo sapiens_hsa046600.56431024
104Leishmaniasis_Homo sapiens_hsa051400.55204991
105Legionellosis_Homo sapiens_hsa051340.54836488
106Pyrimidine metabolism_Homo sapiens_hsa002400.54541674
107Renal cell carcinoma_Homo sapiens_hsa052110.53963144
108Hematopoietic cell lineage_Homo sapiens_hsa046400.53840784
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53472372
110Measles_Homo sapiens_hsa051620.53063531
111Choline metabolism in cancer_Homo sapiens_hsa052310.52316738
112AMPK signaling pathway_Homo sapiens_hsa041520.51623784
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51611584
114Platelet activation_Homo sapiens_hsa046110.51372040
115Oocyte meiosis_Homo sapiens_hsa041140.51142067
116Influenza A_Homo sapiens_hsa051640.50612938
117Inositol phosphate metabolism_Homo sapiens_hsa005620.50411762
118Tight junction_Homo sapiens_hsa045300.49872478
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.49849489
120Vitamin B6 metabolism_Homo sapiens_hsa007500.49601043
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.48371811
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.48216152
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47546666
124HIF-1 signaling pathway_Homo sapiens_hsa040660.47503462
125Alcoholism_Homo sapiens_hsa050340.47090079
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45838887
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45331426
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43739426
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43044770
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42083927
131TNF signaling pathway_Homo sapiens_hsa046680.40570732
132Melanoma_Homo sapiens_hsa052180.40501903
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.39922999
134Regulation of autophagy_Homo sapiens_hsa041400.39432134
135Shigellosis_Homo sapiens_hsa051310.38556893
136Galactose metabolism_Homo sapiens_hsa000520.38408827

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