SCAF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.03018507
2nuclear pore complex assembly (GO:0051292)4.93563138
3nuclear pore organization (GO:0006999)4.49864469
4mitotic sister chromatid cohesion (GO:0007064)4.41660581
5regulation of histone H3-K27 methylation (GO:0061085)4.27913531
6DNA topological change (GO:0006265)4.24998362
7negative regulation of histone methylation (GO:0031061)4.11149945
8DNA unwinding involved in DNA replication (GO:0006268)4.10605551
9histone H3-K36 demethylation (GO:0070544)4.05433029
10regulation of RNA export from nucleus (GO:0046831)4.02244533
11regulation of NFAT protein import into nucleus (GO:0051532)3.96821992
12protein localization to kinetochore (GO:0034501)3.91780149
13heterochromatin organization (GO:0070828)3.91383566
14dosage compensation (GO:0007549)3.90067493
15mitotic nuclear envelope disassembly (GO:0007077)3.88973608
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.87914672
17negative regulation of erythrocyte differentiation (GO:0045647)3.84433465
18regulation of translational fidelity (GO:0006450)3.83495984
19membrane disassembly (GO:0030397)3.60648820
20nuclear envelope disassembly (GO:0051081)3.60648820
21negative regulation of RNA splicing (GO:0033119)3.51866137
22pore complex assembly (GO:0046931)3.51774549
23protein localization to chromosome, centromeric region (GO:0071459)3.51747825
24RNA stabilization (GO:0043489)3.45110836
25mRNA stabilization (GO:0048255)3.45110836
26cytoplasmic mRNA processing body assembly (GO:0033962)3.41608881
27chromosome condensation (GO:0030261)3.41102242
28regulation of histone H3-K9 methylation (GO:0051570)3.40283090
29negative regulation of mRNA processing (GO:0050686)3.40227569
30DNA duplex unwinding (GO:0032508)3.38056058
31histone H3-K4 methylation (GO:0051568)3.35739132
32DNA geometric change (GO:0032392)3.35013719
33histone lysine demethylation (GO:0070076)3.34945938
34intracellular estrogen receptor signaling pathway (GO:0030520)3.32907495
35histone demethylation (GO:0016577)3.31976536
36negative regulation of mRNA metabolic process (GO:1903312)3.30024421
37positive regulation of gene expression, epigenetic (GO:0045815)3.28912027
38regulation of nucleobase-containing compound transport (GO:0032239)3.21777063
39folic acid-containing compound biosynthetic process (GO:0009396)3.21531136
40sister chromatid segregation (GO:0000819)3.20282271
41mitotic chromosome condensation (GO:0007076)3.18352386
42glucocorticoid receptor signaling pathway (GO:0042921)3.16857202
43N-terminal protein amino acid acetylation (GO:0006474)3.16436712
44mitotic sister chromatid segregation (GO:0000070)3.16250627
45protein-DNA complex disassembly (GO:0032986)3.14582301
46nucleosome disassembly (GO:0006337)3.14582301
47DNA packaging (GO:0006323)3.14286388
48histone H3-K9 modification (GO:0061647)3.13441698
49mRNA export from nucleus (GO:0006406)3.11727569
50negative regulation of gene expression, epigenetic (GO:0045814)3.10915265
51histone H4-K12 acetylation (GO:0043983)3.10056351
52regulation of sister chromatid cohesion (GO:0007063)3.08934219
53protein dealkylation (GO:0008214)3.04847662
54protein demethylation (GO:0006482)3.04847662
55mRNA splice site selection (GO:0006376)3.03282216
56gene silencing by RNA (GO:0031047)3.03167792
57NLS-bearing protein import into nucleus (GO:0006607)3.03141645
58V(D)J recombination (GO:0033151)3.01345459
59gene silencing (GO:0016458)2.99019881
60RNA export from nucleus (GO:0006405)2.98503299
61DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.97331039
62histone H2A monoubiquitination (GO:0035518)2.96669321
63positive regulation of chromosome segregation (GO:0051984)2.95998498
64translesion synthesis (GO:0019985)2.95882059
65histone H3-K9 methylation (GO:0051567)2.95256944
66poly(A)+ mRNA export from nucleus (GO:0016973)2.91546482
67alternative mRNA splicing, via spliceosome (GO:0000380)2.91284260
68regulation of chromatin binding (GO:0035561)2.90815521
69nuclear envelope organization (GO:0006998)2.90738249
70positive regulation of gamma-delta T cell activation (GO:0046645)2.89125299
71protein export from nucleus (GO:0006611)2.89045140
72regulation of histone H3-K4 methylation (GO:0051569)2.88611036
73positive regulation of histone deacetylation (GO:0031065)2.88028000
743-UTR-mediated mRNA stabilization (GO:0070935)2.87950493
75positive regulation of granulocyte differentiation (GO:0030854)2.83898447
76regulation of mRNA stability (GO:0043488)2.83202934
77RNA transport (GO:0050658)2.83023399
78establishment of RNA localization (GO:0051236)2.83023399
79nucleic acid transport (GO:0050657)2.83023399
80DNA replication checkpoint (GO:0000076)2.82453525
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81604654
82chromatin silencing (GO:0006342)2.81455407
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80632147
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80632147
85positive regulation of mitotic sister chromatid separation (GO:1901970)2.80632147
86RNA splicing, via transesterification reactions (GO:0000375)2.78653791
87nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.78242032
88histone H4-K16 acetylation (GO:0043984)2.77037733
89chromatin assembly (GO:0031497)2.76556500
90histone mRNA catabolic process (GO:0071044)2.75003755
91histone lysine methylation (GO:0034968)2.74860056
92histone H3-K4 trimethylation (GO:0080182)2.74295471
93mitotic G1 DNA damage checkpoint (GO:0031571)2.73209497
94peptidyl-lysine trimethylation (GO:0018023)2.72704175
95regulation of DNA damage checkpoint (GO:2000001)2.72007988
96histone H4 acetylation (GO:0043967)2.71741627
97regulation of posttranscriptional gene silencing (GO:0060147)2.71496420
98regulation of gene silencing by miRNA (GO:0060964)2.71496420
99regulation of gene silencing by RNA (GO:0060966)2.71496420
100regulation of spindle organization (GO:0090224)2.71185819
101positive thymic T cell selection (GO:0045059)2.71118487
102corticosteroid receptor signaling pathway (GO:0031958)2.70722299
103regulation of RNA stability (GO:0043487)2.70669461
104DNA conformation change (GO:0071103)2.70225494
105definitive hemopoiesis (GO:0060216)2.70213110
106mRNA transport (GO:0051028)2.69258106
107response to UV-C (GO:0010225)2.68761548
108peptidyl-lysine methylation (GO:0018022)2.68532777
109histone H3 acetylation (GO:0043966)2.68508259
110regulation of stem cell maintenance (GO:2000036)2.68314454
111histone H4 deacetylation (GO:0070933)2.68133379
112DNA strand elongation involved in DNA replication (GO:0006271)2.67955520
113internal peptidyl-lysine acetylation (GO:0018393)2.67575311
114histone H3-K9 demethylation (GO:0033169)2.67100981
115DNA damage response, signal transduction resulting in transcription (GO:0042772)2.66065581
116histone methylation (GO:0016571)2.64586215
117spliceosomal tri-snRNP complex assembly (GO:0000244)2.62374319
118regulation of mitotic spindle organization (GO:0060236)2.62359582
119regulation of histone methylation (GO:0031060)2.62299674
120positive regulation of histone methylation (GO:0031062)2.62144267
121trophectodermal cell differentiation (GO:0001829)2.61487909
122peptidyl-lysine acetylation (GO:0018394)2.61390791
123DNA replication initiation (GO:0006270)2.61224473
124protein localization to chromosome (GO:0034502)2.60022076
125kinetochore organization (GO:0051383)2.59587862
126positive regulation by host of viral transcription (GO:0043923)2.59282392
127formation of translation preinitiation complex (GO:0001731)2.58621019
128negative regulation of histone modification (GO:0031057)2.58254868
129chromatin assembly or disassembly (GO:0006333)2.57433281
130IMP biosynthetic process (GO:0006188)2.56646335
131histone acetylation (GO:0016573)2.55849910
132mRNA splicing, via spliceosome (GO:0000398)2.55792911
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.55792911
134DNA strand elongation (GO:0022616)2.55280840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.56318405
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.91340205
3MYC_22102868_ChIP-Seq_BL_Human4.07133072
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.74401585
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97986534
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78267548
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66765972
8VDR_21846776_ChIP-Seq_THP-1_Human2.64193606
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.53992394
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34812417
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34723604
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.22581785
13CIITA_25753668_ChIP-Seq_RAJI_Human2.18564880
14TCF7_22412390_ChIP-Seq_EML_Mouse2.17499263
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06175780
16E2F1_21310950_ChIP-Seq_MCF-7_Human1.99044505
17KDM2B_26808549_Chip-Seq_DND41_Human1.95328162
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92045809
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91245793
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90567821
21MAF_26560356_Chip-Seq_TH1_Human1.74741443
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72618103
23UTX_26944678_Chip-Seq_JUKART_Human1.71004900
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66052489
25AR_21909140_ChIP-Seq_LNCAP_Human1.63996020
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62070242
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61921085
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58168475
29XRN2_22483619_ChIP-Seq_HELA_Human1.57263407
30KDM5A_27292631_Chip-Seq_BREAST_Human1.56730745
31CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52228391
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50125499
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47839337
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46927756
35MYB_26560356_Chip-Seq_TH1_Human1.46178551
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.46140383
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44412012
38SCL_19346495_ChIP-Seq_HPC-7_Human1.38705501
39VDR_24763502_ChIP-Seq_THP-1_Human1.37861936
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37724373
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37627109
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37183406
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34798137
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31393051
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31148595
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30811405
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30332041
48MYB_26560356_Chip-Seq_TH2_Human1.28927715
49* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27768517
50DCP1A_22483619_ChIP-Seq_HELA_Human1.26992639
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26403987
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26261513
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26213399
54NCOR1_26117541_ChIP-Seq_K562_Human1.25835468
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.24703722
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23911610
57GATA1_22025678_ChIP-Seq_K562_Human1.23591774
58MAF_26560356_Chip-Seq_TH2_Human1.23424324
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23317557
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18989417
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.18923196
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18358268
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18110781
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17917669
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17892214
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16800078
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15922028
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.15274879
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14896795
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14738544
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14095994
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13665746
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.13273554
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12202271
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12028934
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11873161
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11730196
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11703567
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11129910
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10913711
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10586332
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10467166
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10247663
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09791681
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09352985
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07533671
87TFEB_21752829_ChIP-Seq_HELA_Human1.07434317
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06079024
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04831247
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04449321
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03558870
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03476414
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02956930
94ATF3_27146783_Chip-Seq_COLON_Human1.02275409
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02064355
96CHD1_26751641_Chip-Seq_LNCaP_Human1.01683701
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.00627164
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99280534
99GABP_19822575_ChIP-Seq_HepG2_Human0.99094485
100FOXP3_21729870_ChIP-Seq_TREG_Human0.98903899
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98728851
102GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98130347
103TTF2_22483619_ChIP-Seq_HELA_Human0.97885106
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97512278
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97493079
106LXR_22292898_ChIP-Seq_THP-1_Human0.97470569
107HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97273135
108HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97201224
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95718086
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94788746
111KDM2B_26808549_Chip-Seq_K562_Human0.93733328
112YY1_21170310_ChIP-Seq_MESCs_Mouse0.93345033
113SPI1_23127762_ChIP-Seq_K562_Human0.93077310
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92443105
115RACK7_27058665_Chip-Seq_MCF-7_Human0.92416848
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90808948
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90676711
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89544144
119SPI1_23547873_ChIP-Seq_NB4_Human0.89248108
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88520832
121GATA6_25053715_ChIP-Seq_YYC3_Human0.87474383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.98508605
2MP0005076_abnormal_cell_differentiation3.33797101
3MP0010352_gastrointestinal_tract_polyps3.24704012
4MP0003111_abnormal_nucleus_morphology3.23010720
5MP0003693_abnormal_embryo_hatching3.09772364
6MP0010094_abnormal_chromosome_stability3.09762635
7MP0002396_abnormal_hematopoietic_system2.96402276
8MP0002009_preneoplasia2.95648895
9MP0003077_abnormal_cell_cycle2.75214239
10MP0004957_abnormal_blastocyst_morpholog2.58759429
11MP0005451_abnormal_body_composition2.53003295
12MP0004808_abnormal_hematopoietic_stem2.15709482
13MP0000350_abnormal_cell_proliferation2.10539006
14MP0001730_embryonic_growth_arrest2.06626482
15MP0009278_abnormal_bone_marrow2.02755509
16MP0010307_abnormal_tumor_latency2.01465054
17MP0000569_abnormal_digit_pigmentation1.96617670
18MP0003705_abnormal_hypodermis_morpholog1.91494901
19MP0001672_abnormal_embryogenesis/_devel1.83439266
20MP0005380_embryogenesis_phenotype1.83439266
21MP0008058_abnormal_DNA_repair1.82884801
22MP0003984_embryonic_growth_retardation1.80523125
23MP0008007_abnormal_cellular_replicative1.78702136
24MP0002088_abnormal_embryonic_growth/wei1.77417249
25MP0004197_abnormal_fetal_growth/weight/1.77092085
26MP0001697_abnormal_embryo_size1.75648498
27MP0003221_abnormal_cardiomyocyte_apopto1.73534144
28MP0002084_abnormal_developmental_patter1.73424061
29MP0005397_hematopoietic_system_phenotyp1.71782102
30MP0001545_abnormal_hematopoietic_system1.71782102
31MP0008961_abnormal_basal_metabolism1.66918263
32MP0002085_abnormal_embryonic_tissue1.66897091
33MP0003890_abnormal_embryonic-extraembry1.63867724
34MP0000703_abnormal_thymus_morphology1.63224276
35MP0003763_abnormal_thymus_physiology1.63060996
36MP0002086_abnormal_extraembryonic_tissu1.62462244
37MP0000490_abnormal_crypts_of1.61120848
38MP0002877_abnormal_melanocyte_morpholog1.59084165
39MP0003300_gastrointestinal_ulcer1.53181781
40MP0002653_abnormal_ependyma_morphology1.50787796
41MP0003656_abnormal_erythrocyte_physiolo1.49778240
42MP0010030_abnormal_orbit_morphology1.49309701
43MP0008877_abnormal_DNA_methylation1.48941571
44MP0002398_abnormal_bone_marrow1.46571248
45MP0002080_prenatal_lethality1.44163127
46MP0009053_abnormal_anal_canal1.41449432
47MP0001293_anophthalmia1.35610428
48MP0001849_ear_inflammation1.34689840
49MP0003303_peritoneal_inflammation1.31619839
50MP0004264_abnormal_extraembryonic_tissu1.31018881
51MP0002249_abnormal_larynx_morphology1.30469850
52MP0000313_abnormal_cell_death1.29529489
53MP0003172_abnormal_lysosome_physiology1.27840991
54MP0002019_abnormal_tumor_incidence1.27053177
55MP0003566_abnormal_cell_adhesion1.26172012
56MP0002722_abnormal_immune_system1.24075494
57MP0000733_abnormal_muscle_development1.20303005
58MP0008260_abnormal_autophagy1.19691940
59MP0003121_genomic_imprinting1.18687181
60MP0008932_abnormal_embryonic_tissue1.18085884
61MP0009672_abnormal_birth_weight1.16442478
62MP0003567_abnormal_fetal_cardiomyocyte1.15411699
63MP0009703_decreased_birth_body1.12995632
64MP0001915_intracranial_hemorrhage1.12580090
65MP0000689_abnormal_spleen_morphology1.12562859
66MP0001800_abnormal_humoral_immune1.08777052
67MP0000678_abnormal_parathyroid_gland1.08645738
68MP0000685_abnormal_immune_system1.07976056
69MP0005023_abnormal_wound_healing1.06225833
70MP0002925_abnormal_cardiovascular_devel1.05362143
71MP0002405_respiratory_system_inflammati1.05204578
72MP0002166_altered_tumor_susceptibility1.03580726
73MP0009333_abnormal_splenocyte_physiolog1.02736244
74MP0004233_abnormal_muscle_weight1.02620440
75MP0000716_abnormal_immune_system0.99079401
76MP0002429_abnormal_blood_cell0.98772911
77MP0003119_abnormal_digestive_system0.97117511
78MP0000537_abnormal_urethra_morphology0.97093594
79MP0000428_abnormal_craniofacial_morphol0.96214603
80MP0009697_abnormal_copulation0.94576667
81MP0002092_abnormal_eye_morphology0.93964620
82MP0005621_abnormal_cell_physiology0.93108099
83MP0004185_abnormal_adipocyte_glucose0.92468780
84MP0001835_abnormal_antigen_presentation0.91863549
85MP0001853_heart_inflammation0.90871149
86MP0009115_abnormal_fat_cell0.89225273
87MP0002006_tumorigenesis0.88128489
88MP0008770_decreased_survivor_rate0.88019518
89MP0003115_abnormal_respiratory_system0.86486253
90MP0005501_abnormal_skin_physiology0.86039285
91MP0005000_abnormal_immune_tolerance0.85779869
92MP0003786_premature_aging0.84303427
93MP0000266_abnormal_heart_morphology0.84291814
94MP0002697_abnormal_eye_size0.83192474
95MP0003123_paternal_imprinting0.82177011
96MP0005384_cellular_phenotype0.82129848
97MP0003935_abnormal_craniofacial_develop0.81177672
98MP0003436_decreased_susceptibility_to0.80390037
99MP0000477_abnormal_intestine_morphology0.80179731
100MP0002970_abnormal_white_adipose0.79936995
101MP0000858_altered_metastatic_potential0.78839937
102MP0005058_abnormal_lysosome_morphology0.78622324
103MP0002420_abnormal_adaptive_immunity0.78568337
104MP0005409_darkened_coat_color0.78214593
105MP0001790_abnormal_immune_system0.77973548
106MP0005387_immune_system_phenotype0.77973548
107MP0002452_abnormal_antigen_presenting0.77791568
108MP0005666_abnormal_adipose_tissue0.77597964
109MP0010630_abnormal_cardiac_muscle0.77249775
110MP0001819_abnormal_immune_cell0.76851759
111MP0005174_abnormal_tail_pigmentation0.74862348
112MP0000432_abnormal_head_morphology0.74657675
113MP0008995_early_reproductive_senescence0.74550862
114MP0009931_abnormal_skin_appearance0.74120290
115MP0010155_abnormal_intestine_physiology0.71544249
116MP0002723_abnormal_immune_serum0.71335120
117MP0005671_abnormal_response_to0.69443729
118MP0000003_abnormal_adipose_tissue0.67972120
119MP0004947_skin_inflammation0.67917876
120MP0003943_abnormal_hepatobiliary_system0.67240237
121MP0002796_impaired_skin_barrier0.67202226
122MP0003453_abnormal_keratinocyte_physiol0.66568709
123MP0005375_adipose_tissue_phenotype0.66476686
124MP0005670_abnormal_white_adipose0.65968742

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.67602542
2Abnormality of the columella (HP:0009929)3.67836839
3Long eyelashes (HP:0000527)3.53182592
4Hyperacusis (HP:0010780)3.28281961
5Increased nuchal translucency (HP:0010880)2.98811707
6Prominent nose (HP:0000448)2.95558909
7Short 4th metacarpal (HP:0010044)2.94619746
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94619746
9Urethral obstruction (HP:0000796)2.90515856
10Volvulus (HP:0002580)2.89557305
11Abnormal number of incisors (HP:0011064)2.88525771
12Ependymoma (HP:0002888)2.87709722
13Bowel incontinence (HP:0002607)2.68970698
14Heterotopia (HP:0002282)2.68499094
15Neoplasm of the oral cavity (HP:0100649)2.67847832
16Abnormal large intestine physiology (HP:0012700)2.62509346
17Deviation of the thumb (HP:0009603)2.56700528
18Renal duplication (HP:0000075)2.53420965
19Anal stenosis (HP:0002025)2.52505984
20Broad face (HP:0000283)2.48043204
21Genetic anticipation (HP:0003743)2.47619593
22Trigonocephaly (HP:0000243)2.47588769
23Proximal placement of thumb (HP:0009623)2.45610868
24Skin tags (HP:0010609)2.45457826
25Abnormality of chromosome segregation (HP:0002916)2.44548735
26Facial hemangioma (HP:0000329)2.43291381
27Cortical dysplasia (HP:0002539)2.41134966
28Ectopic kidney (HP:0000086)2.40271071
29Selective tooth agenesis (HP:0001592)2.36235376
30Medulloblastoma (HP:0002885)2.35254422
31Broad thumb (HP:0011304)2.31386463
32Basal cell carcinoma (HP:0002671)2.26929352
33Astrocytoma (HP:0009592)2.26116983
34Abnormality of the astrocytes (HP:0100707)2.26116983
35Dysmetric saccades (HP:0000641)2.25860208
36Elfin facies (HP:0004428)2.25076926
37Deep palmar crease (HP:0006191)2.24039004
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23949055
39Acute lymphatic leukemia (HP:0006721)2.22809207
40Sparse lateral eyebrow (HP:0005338)2.21908249
41Renovascular hypertension (HP:0100817)2.21179031
42Birth length less than 3rd percentile (HP:0003561)2.20942862
43Reticulocytosis (HP:0001923)2.20486671
44Abnormality of the aortic arch (HP:0012303)2.20325391
45Truncus arteriosus (HP:0001660)2.18061791
46Pseudobulbar signs (HP:0002200)2.16625406
47Narrow palate (HP:0000189)2.15479660
48Preauricular skin tag (HP:0000384)2.13890199
49Abnormal gallbladder physiology (HP:0012438)2.13029400
50Cholecystitis (HP:0001082)2.13029400
51Increased density of long bones (HP:0006392)2.12841467
52Broad palm (HP:0001169)2.12007413
53Aplasia/Hypoplasia of the thymus (HP:0010515)2.09015627
54Macroorchidism (HP:0000053)2.08567837
55Obsessive-compulsive behavior (HP:0000722)2.07194601
56Disproportionate tall stature (HP:0001519)2.07163257
57Skull defect (HP:0001362)2.07069086
58Acute myeloid leukemia (HP:0004808)2.04647268
59Nephroblastoma (Wilms tumor) (HP:0002667)2.04503497
60Cutis marmorata (HP:0000965)2.02456225
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01987883
62Supernumerary ribs (HP:0005815)2.01929001
63Abnormality of the 4th metacarpal (HP:0010012)2.01446358
64Overriding aorta (HP:0002623)2.00790244
65High pitched voice (HP:0001620)2.00063519
66Rib fusion (HP:0000902)1.99939060
67Gastrointestinal stroma tumor (HP:0100723)1.99870720
68Abnormality of the thoracic spine (HP:0100711)1.99209589
69Thoracic kyphosis (HP:0002942)1.98726394
70Neoplasm of striated muscle (HP:0009728)1.98398791
71Fatigue (HP:0012378)1.98127087
72Thick eyebrow (HP:0000574)1.97521039
73Self-mutilation (HP:0000742)1.97229315
74Slow saccadic eye movements (HP:0000514)1.97134152
75Seborrheic dermatitis (HP:0001051)1.96979967
76Septate vagina (HP:0001153)1.96593590
77Overlapping toe (HP:0001845)1.96514650
78Recurrent viral infections (HP:0004429)1.94892625
79Abnormality of homocysteine metabolism (HP:0010919)1.94220959
80Homocystinuria (HP:0002156)1.94220959
81Ankyloglossia (HP:0010296)1.93757422
82Progressive muscle weakness (HP:0003323)1.90497667
83Obstructive sleep apnea (HP:0002870)1.90156249
84T lymphocytopenia (HP:0005403)1.89758509
85Patellar aplasia (HP:0006443)1.86823477
86Truncal obesity (HP:0001956)1.86174976
87Glioma (HP:0009733)1.85553842
88Chromsome breakage (HP:0040012)1.84794554
89Depressed nasal tip (HP:0000437)1.83894051
90Deep philtrum (HP:0002002)1.83625571
91Abnormality of the phalanges of the hallux (HP:0010057)1.82947409
92Capillary hemangiomas (HP:0005306)1.82048067
93Low anterior hairline (HP:0000294)1.81810412
94Abnormality of chromosome stability (HP:0003220)1.81555206
95Gastrointestinal carcinoma (HP:0002672)1.81075501
96Malignant gastrointestinal tract tumors (HP:0006749)1.81075501
97Embryonal renal neoplasm (HP:0011794)1.80887885
98Broad phalanges of the hand (HP:0009768)1.80672004
99Cafe-au-lait spot (HP:0000957)1.80244916
100Intestinal fistula (HP:0100819)1.80100919
101Bicuspid aortic valve (HP:0001647)1.79942820
102Ureteral stenosis (HP:0000071)1.79866142
103High anterior hairline (HP:0009890)1.79305966
104Abnormality of the intervertebral disk (HP:0005108)1.78644118
105Abnormality of the parathyroid morphology (HP:0011766)1.78584411
106Embryonal neoplasm (HP:0002898)1.78086703
107Impulsivity (HP:0100710)1.77919914
108Genu recurvatum (HP:0002816)1.77912934
109Hepatoblastoma (HP:0002884)1.77904687
110Supernumerary bones of the axial skeleton (HP:0009144)1.77673917
111Sandal gap (HP:0001852)1.77226450
112Lymphopenia (HP:0001888)1.76114789
113Shallow orbits (HP:0000586)1.75715684
114Abnormality of the labia minora (HP:0012880)1.74730399
115Insomnia (HP:0100785)1.74361337
116Agammaglobulinemia (HP:0004432)1.72959740
117Spina bifida occulta (HP:0003298)1.72635329
118Sacral dimple (HP:0000960)1.72350114
119Long palpebral fissure (HP:0000637)1.71678078
120Short 5th finger (HP:0009237)1.70993039
121Hypertensive crisis (HP:0100735)1.70580610
122Lip pit (HP:0100267)1.70482441
123Ureteral obstruction (HP:0006000)1.69941222
124Viral hepatitis (HP:0006562)1.69927144
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.69813234
126Myelodysplasia (HP:0002863)1.69807637
127Limited elbow extension (HP:0001377)1.69718289
128Rhabdomyosarcoma (HP:0002859)1.69380680
129Cerebral aneurysm (HP:0004944)1.69137150
130Abnormality of the carotid arteries (HP:0005344)1.68601366
131Panhypogammaglobulinemia (HP:0003139)1.67791065
132Poikiloderma (HP:0001029)1.67424787
133Pointed chin (HP:0000307)1.66799950
134Diastasis recti (HP:0001540)1.66322835
135Colon cancer (HP:0003003)1.66027445
136Progressive external ophthalmoplegia (HP:0000590)1.65669377
137Aplasia/Hypoplasia of the patella (HP:0006498)1.65083716
138Abnormality of cells of the lymphoid lineage (HP:0012140)1.64936151
139Dislocated radial head (HP:0003083)1.64763856
140Chin dimple (HP:0010751)1.64696615
141Peripheral hypomyelination (HP:0007182)1.64610710
142Amaurosis fugax (HP:0100576)1.64602414
143Underdeveloped nasal alae (HP:0000430)1.64593088
144Microvesicular hepatic steatosis (HP:0001414)1.64544339
145Hypoplastic labia majora (HP:0000059)1.63754431
146Distal lower limb amyotrophy (HP:0008944)1.63531767
147Cellulitis (HP:0100658)1.63122961
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.62644196
149Abnormality of T cell number (HP:0011839)1.62008568
150Attention deficit hyperactivity disorder (HP:0007018)1.61518193
151Oligodactyly (HP:0012165)1.60118525
152Abnormality of the diencephalon (HP:0010662)1.60103405
153Short phalanx of the thumb (HP:0009660)1.58612823
154Megalocornea (HP:0000485)1.58318186
155Atresia of the external auditory canal (HP:0000413)1.58022182
156Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57793118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.58164853
2MAP3K103.58801233
3CDC73.17640554
4EEF2K2.92116555
5SMG12.75143281
6BRD42.73643985
7PRPF4B2.60693083
8MAP4K12.55352441
9NEK22.47817626
10CAMK1D2.25258557
11ICK2.08849600
12CAMK1G1.94462076
13ERN11.87462506
14STK101.83955645
15CDK71.77096327
16TAOK11.70870700
17MTOR1.66350633
18RIPK41.65269635
19TTK1.52087554
20CDK41.51962231
21TRIB31.50313879
22ATR1.50093517
23KSR21.45938228
24FGFR41.40066716
25LATS11.38822451
26SIK11.37630256
27RIPK11.35860551
28PKN21.34324094
29CDK61.30041029
30CHEK11.29755004
31STK31.25018160
32MAP3K141.23714413
33SIK21.23221840
34PLK41.21810192
35ALK1.19427084
36RPS6KB21.17992105
37CHEK21.17156415
38RPS6KA41.16559544
39BTK1.14379200
40CHUK1.06948258
41MKNK11.05803693
42CDC42BPA1.00704092
43IRAK41.00557257
44SIK30.99071896
45IRAK30.98206309
46CDK20.97597586
47ATM0.97433285
48PAK40.96056212
49ZAP700.95940942
50STK40.95237180
51MAP3K80.94670227
52DMPK0.92404296
53CDK30.91319514
54MAP3K60.90751998
55PTK60.88494699
56WEE10.87865410
57TESK20.87082908
58BMX0.86156784
59CDK90.85884954
60PLK10.85075805
61PIM10.84276445
62AURKB0.81056258
63JAK30.78204597
64TAOK20.75284934
65BLK0.73637750
66RAF10.73575575
67LRRK20.73429359
68GRK60.72843218
69MAP3K130.70115433
70CSF1R0.69732184
71PASK0.69421401
72DYRK30.68361153
73PAK20.67320245
74MAP3K70.66713008
75CDK10.65551354
76MAP3K110.65289311
77MARK30.64227776
78ERBB20.62541284
79NEK10.62250363
80CAMK40.62167090
81MELK0.61203736
82ITK0.60805843
83MARK20.60270768
84CSK0.59101370
85HCK0.58897078
86WNK10.58832572
87BUB10.57747072
88FGFR10.57576288
89PDGFRA0.57214525
90KSR10.57024845
91MAPK140.56795465
92PTK20.55922365
93YES10.55230744
94CLK10.54996170
95TAOK30.54945715
96SRPK10.54926762
97LATS20.54675411
98PDGFRB0.54540779
99IRAK20.53752141
100TTN0.53544106
101MAPK10.53198173
102MAP2K30.51203003
103KIT0.49799591
104HIPK20.49104697
105PRKDC0.49080821
106TSSK60.48983560
107AKT20.48741336
108MKNK20.48493528
109SCYL20.47867569
110FGFR30.47605185
111RPS6KA10.46771895
112GSK3B0.46530661
113CSNK1E0.45917819
114FLT30.45316974
115DYRK1B0.45183854
116TYRO30.44864015
117MAPK100.44733127
118AKT10.44732523
119TYK20.44448938
120EIF2AK10.43381623
121PRKD20.41249118
122MAPK110.41113790
123LCK0.40754021
124TEC0.39970241
125MAP3K50.39925559
126MAPK80.38838991
127PRKAA10.37943045
128BRSK10.36119332
129EIF2AK20.35204154
130UHMK10.35169766
131MAPK30.33894219
132PIM20.32910055
133SYK0.32440777
134JAK20.31227365
135RPS6KC10.31197305

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.74752373
2RNA transport_Homo sapiens_hsa030132.42862474
3Spliceosome_Homo sapiens_hsa030402.32694781
4Cell cycle_Homo sapiens_hsa041102.32393654
5Mismatch repair_Homo sapiens_hsa034302.32357285
6mRNA surveillance pathway_Homo sapiens_hsa030152.15496745
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09553560
8Lysine degradation_Homo sapiens_hsa003102.03015393
9One carbon pool by folate_Homo sapiens_hsa006701.95284857
10Base excision repair_Homo sapiens_hsa034101.78731437
11Notch signaling pathway_Homo sapiens_hsa043301.78616738
12Chronic myeloid leukemia_Homo sapiens_hsa052201.76794946
13Primary immunodeficiency_Homo sapiens_hsa053401.73737206
14Non-homologous end-joining_Homo sapiens_hsa034501.66572281
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62297410
16MicroRNAs in cancer_Homo sapiens_hsa052061.58915511
17Homologous recombination_Homo sapiens_hsa034401.50750832
18Acute myeloid leukemia_Homo sapiens_hsa052211.49463376
19Herpes simplex infection_Homo sapiens_hsa051681.46007150
20RNA degradation_Homo sapiens_hsa030181.41250706
21p53 signaling pathway_Homo sapiens_hsa041151.40015609
22mTOR signaling pathway_Homo sapiens_hsa041501.39763344
23Fanconi anemia pathway_Homo sapiens_hsa034601.34798868
24HTLV-I infection_Homo sapiens_hsa051661.33815975
25B cell receptor signaling pathway_Homo sapiens_hsa046621.29831729
26Basal cell carcinoma_Homo sapiens_hsa052171.28293712
27Small cell lung cancer_Homo sapiens_hsa052221.27799518
28Colorectal cancer_Homo sapiens_hsa052101.27729070
29Caffeine metabolism_Homo sapiens_hsa002321.26979345
30Adherens junction_Homo sapiens_hsa045201.26791403
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21623115
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20700471
33Antigen processing and presentation_Homo sapiens_hsa046121.16834800
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13571771
35Viral myocarditis_Homo sapiens_hsa054161.12068533
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09731053
37Viral carcinogenesis_Homo sapiens_hsa052031.09646867
38Nucleotide excision repair_Homo sapiens_hsa034201.09340089
39T cell receptor signaling pathway_Homo sapiens_hsa046601.07836119
40Epstein-Barr virus infection_Homo sapiens_hsa051691.07277947
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06648894
42Pancreatic cancer_Homo sapiens_hsa052121.06496822
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06464549
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.06151019
45Hepatitis B_Homo sapiens_hsa051611.03575571
46Non-small cell lung cancer_Homo sapiens_hsa052231.03192039
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01885093
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00941337
49Measles_Homo sapiens_hsa051620.99869774
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99148777
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.96388036
52Hippo signaling pathway_Homo sapiens_hsa043900.95944553
53Endometrial cancer_Homo sapiens_hsa052130.93897153
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.93034336
55Thyroid cancer_Homo sapiens_hsa052160.91203410
56Proteoglycans in cancer_Homo sapiens_hsa052050.90912461
57Bladder cancer_Homo sapiens_hsa052190.89290795
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88931493
59Leishmaniasis_Homo sapiens_hsa051400.86992152
60Hepatitis C_Homo sapiens_hsa051600.86512068
61Prostate cancer_Homo sapiens_hsa052150.86407367
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.83203196
63Choline metabolism in cancer_Homo sapiens_hsa052310.82231116
64TGF-beta signaling pathway_Homo sapiens_hsa043500.81168918
65Osteoclast differentiation_Homo sapiens_hsa043800.80208245
66Dorso-ventral axis formation_Homo sapiens_hsa043200.77132336
67Shigellosis_Homo sapiens_hsa051310.77113383
68VEGF signaling pathway_Homo sapiens_hsa043700.77079244
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76592200
70Selenocompound metabolism_Homo sapiens_hsa004500.76045245
71Biosynthesis of amino acids_Homo sapiens_hsa012300.75999539
72Oocyte meiosis_Homo sapiens_hsa041140.75040598
73Pathways in cancer_Homo sapiens_hsa052000.74622448
74RNA polymerase_Homo sapiens_hsa030200.74612733
75Basal transcription factors_Homo sapiens_hsa030220.74402146
76Inositol phosphate metabolism_Homo sapiens_hsa005620.74303470
77Apoptosis_Homo sapiens_hsa042100.74024859
78Renal cell carcinoma_Homo sapiens_hsa052110.73978600
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73960209
80Hedgehog signaling pathway_Homo sapiens_hsa043400.73953169
81HIF-1 signaling pathway_Homo sapiens_hsa040660.73237113
82Other glycan degradation_Homo sapiens_hsa005110.72732478
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72636760
84Wnt signaling pathway_Homo sapiens_hsa043100.72422082
85Toxoplasmosis_Homo sapiens_hsa051450.69295583
86Tuberculosis_Homo sapiens_hsa051520.69131112
87Hematopoietic cell lineage_Homo sapiens_hsa046400.68110643
88Influenza A_Homo sapiens_hsa051640.67421015
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66762156
90Insulin resistance_Homo sapiens_hsa049310.66648806
91Prolactin signaling pathway_Homo sapiens_hsa049170.65526255
92Glioma_Homo sapiens_hsa052140.61516488
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60750513
94Pyrimidine metabolism_Homo sapiens_hsa002400.60523572
95FoxO signaling pathway_Homo sapiens_hsa040680.59309373
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.58560238
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.57766845
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56432926
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.56076402
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.54065318
101TNF signaling pathway_Homo sapiens_hsa046680.53783117
102Legionellosis_Homo sapiens_hsa051340.53589207
103AMPK signaling pathway_Homo sapiens_hsa041520.53172333
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52877962
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50441795
106Steroid biosynthesis_Homo sapiens_hsa001000.49982907
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49342044
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47157627
109Type II diabetes mellitus_Homo sapiens_hsa049300.47020800
110Insulin signaling pathway_Homo sapiens_hsa049100.46647610
111ErbB signaling pathway_Homo sapiens_hsa040120.45936282
112Pentose phosphate pathway_Homo sapiens_hsa000300.45896725
113Platelet activation_Homo sapiens_hsa046110.43126612
114Allograft rejection_Homo sapiens_hsa053300.41932619
115Estrogen signaling pathway_Homo sapiens_hsa049150.41147174
116Graft-versus-host disease_Homo sapiens_hsa053320.35163988

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