SCAI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.47168447
2neuron cell-cell adhesion (GO:0007158)5.24830822
3vocalization behavior (GO:0071625)5.14435435
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88545991
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.87752496
6synaptic vesicle exocytosis (GO:0016079)4.81626451
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.75186251
8presynaptic membrane assembly (GO:0097105)4.66995297
9glutamate secretion (GO:0014047)4.58496679
10protein localization to synapse (GO:0035418)4.53675579
11locomotory exploration behavior (GO:0035641)4.49809215
12regulation of glutamate receptor signaling pathway (GO:1900449)4.49705393
13regulation of synaptic vesicle exocytosis (GO:2000300)4.42662020
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35346698
15glutamate receptor signaling pathway (GO:0007215)4.32648389
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32579313
17presynaptic membrane organization (GO:0097090)4.28120603
18negative regulation of synaptic transmission, GABAergic (GO:0032229)4.20023036
19startle response (GO:0001964)4.18595443
20synaptic transmission, glutamatergic (GO:0035249)4.07722181
21neuron recognition (GO:0008038)4.06572854
22exploration behavior (GO:0035640)4.04073145
23synaptic vesicle maturation (GO:0016188)4.00232416
24behavioral response to nicotine (GO:0035095)3.98503366
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.96404910
26neuron-neuron synaptic transmission (GO:0007270)3.92832859
27postsynaptic membrane organization (GO:0001941)3.90903935
28regulation of synaptic vesicle transport (GO:1902803)3.89652156
29axonal fasciculation (GO:0007413)3.88048563
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.86748303
31neurotransmitter secretion (GO:0007269)3.86290713
32layer formation in cerebral cortex (GO:0021819)3.84108842
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79453298
34neuronal action potential propagation (GO:0019227)3.77970896
35gamma-aminobutyric acid transport (GO:0015812)3.75049196
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74578804
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66191131
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.60977015
39regulation of neuronal synaptic plasticity (GO:0048168)3.56292360
40L-fucose catabolic process (GO:0042355)3.54380457
41fucose catabolic process (GO:0019317)3.54380457
42L-fucose metabolic process (GO:0042354)3.54380457
43regulation of postsynaptic membrane potential (GO:0060078)3.52278852
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48918251
45proline transport (GO:0015824)3.46710562
46dendritic spine morphogenesis (GO:0060997)3.44300690
47neurotransmitter-gated ion channel clustering (GO:0072578)3.42679953
48synaptic vesicle endocytosis (GO:0048488)3.40509424
49long-term synaptic potentiation (GO:0060291)3.38906620
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35685099
51auditory behavior (GO:0031223)3.35124243
52innervation (GO:0060384)3.34241553
53long-term memory (GO:0007616)3.32221583
54cerebellar Purkinje cell differentiation (GO:0021702)3.31782006
55synapse assembly (GO:0007416)3.29805911
56response to histamine (GO:0034776)3.28555501
57nonmotile primary cilium assembly (GO:0035058)3.28266368
58central nervous system projection neuron axonogenesis (GO:0021952)3.24810382
59neurotransmitter transport (GO:0006836)3.22507377
60positive regulation of synapse maturation (GO:0090129)3.22165506
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21972786
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.18212082
63regulation of neurotransmitter secretion (GO:0046928)3.18122672
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17487147
65protein K11-linked deubiquitination (GO:0035871)3.16555349
66positive regulation of membrane potential (GO:0045838)3.15807988
67regulation of dendritic spine morphogenesis (GO:0061001)3.14383119
68transmission of nerve impulse (GO:0019226)3.14036740
69mechanosensory behavior (GO:0007638)3.13307007
70cochlea development (GO:0090102)3.13191937
71cerebellar granule cell differentiation (GO:0021707)3.11993394
72positive regulation of synapse assembly (GO:0051965)3.11814158
73pyrimidine nucleobase catabolic process (GO:0006208)3.10358663
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09576787
75negative regulation of translation, ncRNA-mediated (GO:0040033)3.09576787
76regulation of translation, ncRNA-mediated (GO:0045974)3.09576787
77negative regulation of DNA-dependent DNA replication (GO:2000104)3.09425821
78dendrite morphogenesis (GO:0048813)3.09223455
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08873294
80regulation of synaptic plasticity (GO:0048167)3.07679449
81regulation of vesicle fusion (GO:0031338)3.07568700
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07526468
83regulation of respiratory system process (GO:0044065)3.04823801
84neural tube formation (GO:0001841)3.02028322
85positive regulation of neurotransmitter secretion (GO:0001956)3.00299920
86response to pheromone (GO:0019236)2.98739338
87detection of light stimulus involved in visual perception (GO:0050908)2.98737580
88detection of light stimulus involved in sensory perception (GO:0050962)2.98737580
89behavioral defense response (GO:0002209)2.98423459
90behavioral fear response (GO:0001662)2.98423459
91response to auditory stimulus (GO:0010996)2.97307547
92reflex (GO:0060004)2.96568107
93synapse organization (GO:0050808)2.94764069
94cellular potassium ion homeostasis (GO:0030007)2.94510914
95membrane depolarization (GO:0051899)2.94040426
96regulation of synaptic transmission, GABAergic (GO:0032228)2.93871050
97cAMP catabolic process (GO:0006198)2.93839907
98regulation of synapse structural plasticity (GO:0051823)2.92525793
99regulation of meiosis I (GO:0060631)2.92008070
100regulation of neurotransmitter levels (GO:0001505)2.89742645
101retinal cone cell development (GO:0046549)2.89465014
102learning (GO:0007612)2.88919395
103kidney morphogenesis (GO:0060993)2.88640532
104detection of calcium ion (GO:0005513)2.86559686
105serotonin metabolic process (GO:0042428)2.83691617
106regulation of synapse assembly (GO:0051963)2.82765271
107photoreceptor cell maintenance (GO:0045494)2.82510952
108regulation of dendritic spine development (GO:0060998)2.82358826
109regulation of neurotransmitter transport (GO:0051588)2.80910315
110membrane depolarization during action potential (GO:0086010)2.80359271
111fear response (GO:0042596)2.80055011
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.79636194
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77918374
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77897265
115auditory receptor cell stereocilium organization (GO:0060088)2.75996211
116neuronal action potential (GO:0019228)2.75236531
117social behavior (GO:0035176)2.74254275
118intraspecies interaction between organisms (GO:0051703)2.74254275
119serotonin receptor signaling pathway (GO:0007210)2.73723675
120dendrite development (GO:0016358)2.72351084
121regulation of synapse maturation (GO:0090128)2.72156093
122synaptic transmission (GO:0007268)2.71416265
123regulation of respiratory gaseous exchange (GO:0043576)2.70725470
124activation of protein kinase A activity (GO:0034199)2.70100963
125cyclic nucleotide catabolic process (GO:0009214)2.69666394
126positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.68665683
127positive regulation of neurotransmitter transport (GO:0051590)2.68526593
128vesicle transport along microtubule (GO:0047496)2.68355779
129negative regulation of neurotransmitter transport (GO:0051589)2.68230175
130protein polyglutamylation (GO:0018095)2.67217418
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.65781087
132primary amino compound metabolic process (GO:1901160)2.64780543
133behavioral response to ethanol (GO:0048149)2.64649277
134inner ear receptor stereocilium organization (GO:0060122)2.64254966
135regulation of posttranscriptional gene silencing (GO:0060147)2.62844247
136regulation of gene silencing by miRNA (GO:0060964)2.62844247
137regulation of gene silencing by RNA (GO:0060966)2.62844247
138nucleobase catabolic process (GO:0046113)2.62120181
139piRNA metabolic process (GO:0034587)2.60771332
140replication fork processing (GO:0031297)2.58641781
141righting reflex (GO:0060013)2.55965505
142DNA double-strand break processing (GO:0000729)2.55156569
143interkinetic nuclear migration (GO:0022027)2.54902067
144centriole replication (GO:0007099)2.53112441
145atrial cardiac muscle cell action potential (GO:0086014)2.52105376
146detection of mechanical stimulus involved in sensory perception (GO:0050974)2.49363935
147spinal cord motor neuron differentiation (GO:0021522)2.49199962
148indolalkylamine metabolic process (GO:0006586)2.48576822
149positive regulation of meiosis (GO:0045836)2.46863028
150RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46832319
151C4-dicarboxylate transport (GO:0015740)2.46305135
152epithelial cilium movement (GO:0003351)2.43864284
153axoneme assembly (GO:0035082)2.42533644
154protein localization to cilium (GO:0061512)2.42507454
155regulation of action potential (GO:0098900)2.42236061
156action potential (GO:0001508)2.40316028
157somite development (GO:0061053)2.38371929
158regulation of mesoderm development (GO:2000380)2.37600051
159regulation of telomere maintenance (GO:0032204)2.36993157
160photoreceptor cell development (GO:0042461)2.36992605
161DNA methylation involved in gamete generation (GO:0043046)2.36347218
162reciprocal meiotic recombination (GO:0007131)2.35995508
163reciprocal DNA recombination (GO:0035825)2.35995508
164cytoplasmic mRNA processing body assembly (GO:0033962)2.33331894
165regulation of hippo signaling (GO:0035330)2.32531226
166indole-containing compound metabolic process (GO:0042430)2.32141480
167cilium organization (GO:0044782)2.32063449
168adult walking behavior (GO:0007628)2.31377971
169neuromuscular synaptic transmission (GO:0007274)2.31211390
170limb bud formation (GO:0060174)2.30635433
171regulation of collateral sprouting (GO:0048670)2.29917666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01301140
2GBX2_23144817_ChIP-Seq_PC3_Human4.12890109
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78773852
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74650072
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68023056
6TAF15_26573619_Chip-Seq_HEK293_Human2.49133630
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47509030
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44171809
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37424200
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31915273
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31915273
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.31691574
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26078812
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22483385
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21095006
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19890522
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.17369551
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16687873
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15306990
20REST_21632747_ChIP-Seq_MESCs_Mouse2.14102726
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11627484
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03439311
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03325438
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00849714
25SMAD4_21799915_ChIP-Seq_A2780_Human1.96062299
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94917275
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.94290671
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93452087
29DROSHA_22980978_ChIP-Seq_HELA_Human1.90101417
30P300_19829295_ChIP-Seq_ESCs_Human1.89687192
31FUS_26573619_Chip-Seq_HEK293_Human1.89587593
32AR_21572438_ChIP-Seq_LNCaP_Human1.89052775
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87988175
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.86484636
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85113636
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77601462
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.74055965
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73744016
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73285805
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.71274281
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68986963
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.68475049
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.64430196
44IGF1R_20145208_ChIP-Seq_DFB_Human1.61815986
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60277371
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.59050885
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55634952
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55305181
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52775717
50ZNF274_21170338_ChIP-Seq_K562_Hela1.52254131
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.51435196
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51318193
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50017592
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48676409
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47706585
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47383749
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47248083
58* STAT3_23295773_ChIP-Seq_U87_Human1.47093491
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45673520
60AR_25329375_ChIP-Seq_VCAP_Human1.44315159
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43073420
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42602722
63CBP_20019798_ChIP-Seq_JUKART_Human1.42602722
64RNF2_27304074_Chip-Seq_NSC_Mouse1.39629533
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39383238
66IRF1_19129219_ChIP-ChIP_H3396_Human1.38458499
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37581795
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.37486514
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.35622099
70TP53_16413492_ChIP-PET_HCT116_Human1.34927257
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33617697
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31523204
73TCF4_23295773_ChIP-Seq_U87_Human1.31148204
74* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28838607
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28463065
76EWS_26573619_Chip-Seq_HEK293_Human1.27177615
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27030479
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26414528
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26223942
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.24996608
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24903618
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24903618
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24556629
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24261187
85ER_23166858_ChIP-Seq_MCF-7_Human1.24028590
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23805753
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23702429
88TP53_18474530_ChIP-ChIP_U2OS_Human1.23023896
89TP53_22573176_ChIP-Seq_HFKS_Human1.22462887
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22062387
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.21162669
92AHR_22903824_ChIP-Seq_MCF-7_Human1.19558909
93RUNX2_22187159_ChIP-Seq_PCA_Human1.19519655
94BCAT_22108803_ChIP-Seq_LS180_Human1.18781358
95* TCF4_22108803_ChIP-Seq_LS180_Human1.18753980
96AR_19668381_ChIP-Seq_PC3_Human1.18631432
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17673524
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.17221389
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16994994
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16986952
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.16827916
102VDR_22108803_ChIP-Seq_LS180_Human1.15477479
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.14220321
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12904396
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.10319721
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09943181
107JUN_21703547_ChIP-Seq_K562_Human1.09112363
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.08511781
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08435699
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08309848
111NANOG_19829295_ChIP-Seq_ESCs_Human1.07648306
112SOX2_19829295_ChIP-Seq_ESCs_Human1.07648306
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07202333
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06759134
115SALL1_21062744_ChIP-ChIP_HESCs_Human1.06747970
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06578480
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.06289739
118MYC_18940864_ChIP-ChIP_HL60_Human1.06030599
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.05696297
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05308285
121TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04180750
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03406552
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02465642
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.01927231
125P53_22387025_ChIP-Seq_ESCs_Mouse1.01849143
126PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01295708
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.00533758
128KDM2B_26808549_Chip-Seq_REH_Human1.00494578
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00081448
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98447521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.39431982
2MP0003880_abnormal_central_pattern4.64247277
3MP0003635_abnormal_synaptic_transmissio3.82225978
4MP0009745_abnormal_behavioral_response3.16412092
5MP0004270_analgesia3.14407264
6MP0002063_abnormal_learning/memory/cond3.14126665
7MP0009046_muscle_twitch2.94628906
8MP0001968_abnormal_touch/_nociception2.90898561
9MP0002064_seizures2.87374525
10MP0002572_abnormal_emotion/affect_behav2.77979153
11MP0001486_abnormal_startle_reflex2.52416660
12MP0002734_abnormal_mechanical_nocicepti2.45932628
13MP0005423_abnormal_somatic_nervous2.45572995
14MP0008057_abnormal_DNA_replication2.35595105
15MP0003787_abnormal_imprinting2.33235308
16MP0002736_abnormal_nociception_after2.30979661
17MP0001188_hyperpigmentation2.29222783
18MP0002272_abnormal_nervous_system2.26199861
19MP0000778_abnormal_nervous_system2.22688099
20MP0000569_abnormal_digit_pigmentation2.21479655
21MP0002735_abnormal_chemical_nociception2.20942765
22MP0001501_abnormal_sleep_pattern2.08754997
23MP0002184_abnormal_innervation2.07255672
24MP0003890_abnormal_embryonic-extraembry2.03051265
25MP0002067_abnormal_sensory_capabilities2.01555814
26MP0001440_abnormal_grooming_behavior1.96831731
27MP0001984_abnormal_olfaction1.93632621
28MP0002733_abnormal_thermal_nociception1.92762540
29MP0006276_abnormal_autonomic_nervous1.89627003
30MP0002557_abnormal_social/conspecific_i1.86929392
31MP0005646_abnormal_pituitary_gland1.82465366
32MP0003122_maternal_imprinting1.79711863
33MP0001970_abnormal_pain_threshold1.75354639
34MP0004924_abnormal_behavior1.73022452
35MP0005386_behavior/neurological_phenoty1.73022452
36MP0009780_abnormal_chondrocyte_physiolo1.72603485
37MP0004147_increased_porphyrin_level1.62661784
38MP0001986_abnormal_taste_sensitivity1.53029471
39MP0008569_lethality_at_weaning1.52901824
40MP0005645_abnormal_hypothalamus_physiol1.52693610
41MP0003646_muscle_fatigue1.51256178
42MP0005409_darkened_coat_color1.50879943
43MP0004811_abnormal_neuron_physiology1.50232317
44MP0000955_abnormal_spinal_cord1.40903369
45MP0003121_genomic_imprinting1.40090523
46MP0001502_abnormal_circadian_rhythm1.39958876
47MP0002882_abnormal_neuron_morphology1.36686420
48MP0005499_abnormal_olfactory_system1.25755831
49MP0005394_taste/olfaction_phenotype1.25755831
50MP0004043_abnormal_pH_regulation1.25755828
51MP0002066_abnormal_motor_capabilities/c1.24576001
52MP0002822_catalepsy1.23780693
53MP0003136_yellow_coat_color1.23345890
54MP0000631_abnormal_neuroendocrine_gland1.21757908
55MP0003718_maternal_effect1.20539298
56MP0001905_abnormal_dopamine_level1.19742704
57MP0000427_abnormal_hair_cycle1.19449067
58MP0002152_abnormal_brain_morphology1.19364367
59MP0003879_abnormal_hair_cell1.17409546
60MP0003119_abnormal_digestive_system1.17327416
61MP0004885_abnormal_endolymph1.16124288
62MP0004858_abnormal_nervous_system1.14811401
63MP0003195_calcinosis1.13508384
64MP0000383_abnormal_hair_follicle1.12152166
65MP0008872_abnormal_physiological_respon1.11237128
66MP0002234_abnormal_pharynx_morphology1.09543120
67MP0002938_white_spotting1.08730934
68MP0001529_abnormal_vocalization1.08415021
69MP0004133_heterotaxia1.07203805
70MP0004742_abnormal_vestibular_system1.06521106
71MP0003937_abnormal_limbs/digits/tail_de1.03637643
72MP0002909_abnormal_adrenal_gland1.03603229
73MP0005551_abnormal_eye_electrophysiolog1.02380458
74MP0001293_anophthalmia1.01013371
75MP0002160_abnormal_reproductive_system1.01005459
76MP0004484_altered_response_of0.99733888
77MP0002876_abnormal_thyroid_physiology0.99419875
78MP0000015_abnormal_ear_pigmentation0.96946419
79MP0001963_abnormal_hearing_physiology0.96307287
80MP0003633_abnormal_nervous_system0.95958532
81MP0005187_abnormal_penis_morphology0.95194681
82MP0003123_paternal_imprinting0.94740905
83MP0001177_atelectasis0.93953842
84MP0004142_abnormal_muscle_tone0.93329927
85MP0005171_absent_coat_pigmentation0.92671044
86MP0002751_abnormal_autonomic_nervous0.91501344
87MP0008058_abnormal_DNA_repair0.89652330
88MP0008789_abnormal_olfactory_epithelium0.89046981
89MP0003283_abnormal_digestive_organ0.88365460
90MP0010386_abnormal_urinary_bladder0.87197476
91MP0002102_abnormal_ear_morphology0.85644146
92MP0003698_abnormal_male_reproductive0.85521567
93MP0003631_nervous_system_phenotype0.85451838
94MP0005195_abnormal_posterior_eye0.85093629
95MP0002752_abnormal_somatic_nervous0.83260685
96MP0003861_abnormal_nervous_system0.81877593
97MP0008995_early_reproductive_senescence0.81599794
98MP0008877_abnormal_DNA_methylation0.81126389
99MP0002095_abnormal_skin_pigmentation0.80844538
100MP0003567_abnormal_fetal_cardiomyocyte0.79706431
101MP0006292_abnormal_olfactory_placode0.79587684
102MP0008775_abnormal_heart_ventricle0.79330446
103MP0001929_abnormal_gametogenesis0.78332858
104MP0002653_abnormal_ependyma_morphology0.78307021
105MP0002210_abnormal_sex_determination0.78191860
106MP0003329_amyloid_beta_deposits0.77643565
107MP0004085_abnormal_heartbeat0.77516276
108MP0002928_abnormal_bile_duct0.77306141
109MP0004145_abnormal_muscle_electrophysio0.77283897
110MP0002069_abnormal_eating/drinking_beha0.76697711
111MP0000026_abnormal_inner_ear0.76473311
112MP0004215_abnormal_myocardial_fiber0.71601712
113MP0001485_abnormal_pinna_reflex0.71272715
114MP0003938_abnormal_ear_development0.69757433
115MP0006072_abnormal_retinal_apoptosis0.69476958
116MP0002229_neurodegeneration0.68106368
117MP0002837_dystrophic_cardiac_calcinosis0.67666384
118MP0000537_abnormal_urethra_morphology0.65634653
119MP0000049_abnormal_middle_ear0.64793085
120MP0001943_abnormal_respiration0.64477987
121MP0005248_abnormal_Harderian_gland0.64356103
122MP0001299_abnormal_eye_distance/0.63907897
123MP0009379_abnormal_foot_pigmentation0.61797298
124MP0003632_abnormal_nervous_system0.61370793
125MP0010234_abnormal_vibrissa_follicle0.58396350
126MP0002638_abnormal_pupillary_reflex0.58138043
127MP0003385_abnormal_body_wall0.57786796
128MP0010770_preweaning_lethality0.57712637
129MP0002082_postnatal_lethality0.57712637
130MP0005174_abnormal_tail_pigmentation0.56687712
131MP0003634_abnormal_glial_cell0.56238833
132MP0005253_abnormal_eye_physiology0.55996064

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.05156799
2Focal seizures (HP:0007359)5.03945519
3Febrile seizures (HP:0002373)4.74429660
4Epileptic encephalopathy (HP:0200134)4.52666436
5Atonic seizures (HP:0010819)4.27345632
6Visual hallucinations (HP:0002367)4.18454409
7Hyperventilation (HP:0002883)4.16958848
8Pancreatic cysts (HP:0001737)3.81092222
9Broad-based gait (HP:0002136)3.76932020
10Absence seizures (HP:0002121)3.68800108
11Progressive cerebellar ataxia (HP:0002073)3.61085081
12Myokymia (HP:0002411)3.50439519
13Pancreatic fibrosis (HP:0100732)3.44855464
14Dialeptic seizures (HP:0011146)3.41099014
15Absent speech (HP:0001344)3.38683208
16Molar tooth sign on MRI (HP:0002419)3.36786928
17Abnormality of midbrain morphology (HP:0002418)3.36786928
18Excessive salivation (HP:0003781)3.35873667
19Drooling (HP:0002307)3.35873667
20Nephronophthisis (HP:0000090)3.27760585
21Type II lissencephaly (HP:0007260)3.22054811
22True hermaphroditism (HP:0010459)3.18603444
23Generalized tonic-clonic seizures (HP:0002069)3.18486213
24Gaze-evoked nystagmus (HP:0000640)3.09171969
25Congenital stationary night blindness (HP:0007642)3.00300653
26Protruding tongue (HP:0010808)3.00067610
27Truncal ataxia (HP:0002078)2.89670189
28Abnormality of the renal medulla (HP:0100957)2.88981411
29Abnormality of the renal cortex (HP:0011035)2.81806636
30Poor eye contact (HP:0000817)2.64918647
31Chronic hepatic failure (HP:0100626)2.64823169
32Aqueductal stenosis (HP:0002410)2.63096691
33Gait imbalance (HP:0002141)2.63001443
34Amblyopia (HP:0000646)2.60703409
35Urinary bladder sphincter dysfunction (HP:0002839)2.57975502
36Abnormality of binocular vision (HP:0011514)2.57870165
37Diplopia (HP:0000651)2.57870165
38Impaired vibration sensation in the lower limbs (HP:0002166)2.56397613
39Lissencephaly (HP:0001339)2.52288143
40Genetic anticipation (HP:0003743)2.48988635
41Fair hair (HP:0002286)2.45658045
42Abolished electroretinogram (ERG) (HP:0000550)2.43123815
43Inappropriate behavior (HP:0000719)2.43103237
44Blue irides (HP:0000635)2.39629052
45Abnormality of the labia minora (HP:0012880)2.38921829
46Dysdiadochokinesis (HP:0002075)2.38094353
47Colon cancer (HP:0003003)2.37491015
48Widely spaced teeth (HP:0000687)2.36328541
49Epileptiform EEG discharges (HP:0011182)2.36268223
50Progressive inability to walk (HP:0002505)2.35921394
51Cystic liver disease (HP:0006706)2.35482472
52Tubular atrophy (HP:0000092)2.35441080
53Abnormal hair whorl (HP:0010721)2.35404739
54Abnormality of salivation (HP:0100755)2.34471325
55Stomach cancer (HP:0012126)2.33385096
56Generalized hypopigmentation of hair (HP:0011358)2.32393048
57Abnormal social behavior (HP:0012433)2.31405460
58Impaired social interactions (HP:0000735)2.31405460
59Attenuation of retinal blood vessels (HP:0007843)2.31042620
60Polydipsia (HP:0001959)2.28803818
61Abnormal drinking behavior (HP:0030082)2.28803818
62Inability to walk (HP:0002540)2.27474733
63Action tremor (HP:0002345)2.26410855
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.21026612
65Impaired smooth pursuit (HP:0007772)2.20791579
66Congenital primary aphakia (HP:0007707)2.20455232
67Cerebellar dysplasia (HP:0007033)2.19848941
68Hemiparesis (HP:0001269)2.19347222
69Optic nerve hypoplasia (HP:0000609)2.17927679
70EEG with generalized epileptiform discharges (HP:0011198)2.16928330
71Medial flaring of the eyebrow (HP:0010747)2.16398106
72Retinal dysplasia (HP:0007973)2.14835857
73Papilledema (HP:0001085)2.14566610
74Limb dystonia (HP:0002451)2.13880873
75Exotropia (HP:0000577)2.12701941
76Pendular nystagmus (HP:0012043)2.12338134
77Urinary urgency (HP:0000012)2.09803739
78Stereotypic behavior (HP:0000733)2.09795697
79Dysmetria (HP:0001310)2.08754323
80Abnormality of the corticospinal tract (HP:0002492)2.06660426
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06257257
82Nephrogenic diabetes insipidus (HP:0009806)2.06130181
83Ankle clonus (HP:0011448)2.05524048
84Anxiety (HP:0000739)2.04212218
85Renal cortical cysts (HP:0000803)2.03708591
86Gastroesophageal reflux (HP:0002020)2.03117693
87Depression (HP:0000716)2.02891490
88Oligodactyly (hands) (HP:0001180)2.00957460
89Scanning speech (HP:0002168)2.00792919
90Hypsarrhythmia (HP:0002521)2.00333939
91Genital tract atresia (HP:0001827)1.99670459
92Thyroid-stimulating hormone excess (HP:0002925)1.98720293
93Spastic gait (HP:0002064)1.97207264
94Abnormality of ocular smooth pursuit (HP:0000617)1.96520457
95Vaginal atresia (HP:0000148)1.96477010
96Hepatoblastoma (HP:0002884)1.95703992
97Clumsiness (HP:0002312)1.94822065
98Patellar aplasia (HP:0006443)1.94567087
99Bile duct proliferation (HP:0001408)1.94062146
100Abnormal biliary tract physiology (HP:0012439)1.94062146
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.93326964
102Birth length less than 3rd percentile (HP:0003561)1.91067421
103Decreased circulating renin level (HP:0003351)1.90945985
104Fetal akinesia sequence (HP:0001989)1.89845582
105Small hand (HP:0200055)1.89742906
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.89463219
107Supranuclear gaze palsy (HP:0000605)1.87732649
108Pheochromocytoma (HP:0002666)1.87479169
109Specific learning disability (HP:0001328)1.84543867
110Sclerocornea (HP:0000647)1.84118412
111Agitation (HP:0000713)1.83941531
112Anencephaly (HP:0002323)1.83482901
113Termporal pattern (HP:0011008)1.83409436
114Insidious onset (HP:0003587)1.83409436
115Neoplasm of the adrenal cortex (HP:0100641)1.83120448
116Poor coordination (HP:0002370)1.82953116
117Aplasia/Hypoplasia of the patella (HP:0006498)1.82866456
118Amyotrophic lateral sclerosis (HP:0007354)1.81890545
119Deeply set eye (HP:0000490)1.81768851
120Pachygyria (HP:0001302)1.81015381
121Supernumerary spleens (HP:0009799)1.80486211
122Narrow nasal bridge (HP:0000446)1.80435437
123Intestinal atresia (HP:0011100)1.80262272
124Autism (HP:0000717)1.79736879
125Mutism (HP:0002300)1.79578085
126Decreased central vision (HP:0007663)1.79343234
127Postural instability (HP:0002172)1.78444012
128Postaxial hand polydactyly (HP:0001162)1.77274353
129Congenital hepatic fibrosis (HP:0002612)1.77178441
130Chorioretinal atrophy (HP:0000533)1.76955209
131Impaired vibratory sensation (HP:0002495)1.75838231
132Postaxial foot polydactyly (HP:0001830)1.74523589
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.74086105
134Absent/shortened dynein arms (HP:0200106)1.74086105
135Abnormality of the ileum (HP:0001549)1.72234249
136Lower limb muscle weakness (HP:0007340)1.71768651
137Sporadic (HP:0003745)1.71456074
138Abnormal eating behavior (HP:0100738)1.70750087
139Bradykinesia (HP:0002067)1.69670748
140Congenital sensorineural hearing impairment (HP:0008527)1.69343063
141Dandy-Walker malformation (HP:0001305)1.69109334
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.68693059
143Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68693059
144Septo-optic dysplasia (HP:0100842)1.68617843
145Dyskinesia (HP:0100660)1.67828817
146Meckel diverticulum (HP:0002245)1.67769459
147Thyroiditis (HP:0100646)1.67766625
148Volvulus (HP:0002580)1.67712248
149Tented upper lip vermilion (HP:0010804)1.67457201
150Furrowed tongue (HP:0000221)1.66569153
151Partial agenesis of the corpus callosum (HP:0001338)1.66398422
152Gait ataxia (HP:0002066)1.63361183
153Short foot (HP:0001773)1.62540034
154Keratoconus (HP:0000563)1.62412531
155Increased corneal curvature (HP:0100692)1.62412531
156Astigmatism (HP:0000483)1.62393298
157Preaxial hand polydactyly (HP:0001177)1.62095678
158Hyperthyroidism (HP:0000836)1.62035823
159Neuroendocrine neoplasm (HP:0100634)1.61987261
160Obsessive-compulsive behavior (HP:0000722)1.61929130
161Macroorchidism (HP:0000053)1.58748596
162Macroglossia (HP:0000158)1.58679732
163Hemiplegia (HP:0002301)1.58420941
164Thickened helices (HP:0000391)1.57818483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.21775589
2EPHA43.81038368
3MAP3K43.78741351
4MARK13.53145474
5MAP2K73.52029563
6CASK3.35792391
7MAP3K92.63429592
8BMPR1B2.52952772
9ACVR1B2.41729837
10NTRK22.36974617
11PNCK2.23671890
12RIPK42.15696501
13ZAK2.12412558
14MAP4K22.12099422
15MAP2K42.05146965
16MINK12.03018823
17NUAK12.00977375
18ADRBK21.97415949
19MAPK131.93537454
20PINK11.86713723
21PLK21.83253779
22MAP3K121.81140630
23GRK11.68654149
24DAPK21.66213571
25WNK41.65863959
26KSR11.58104140
27TNIK1.56171896
28TAOK31.54634274
29SIK21.52154086
30SGK21.36700874
31PAK61.36113003
32CDK51.30727161
33DAPK11.30172814
34CSNK1G21.27044539
35STK391.26295680
36BMPR21.24638407
37CAMK1G1.21856267
38GRK51.19473751
39TRIM281.15507099
40NLK1.14451054
41ERBB31.13563275
42PRKCG1.13549626
43MAP3K61.12050786
44CAMK2A1.08919483
45MKNK11.08544946
46TLK11.05831244
47SGK2231.03684348
48SGK4941.03684348
49MAP3K21.02307597
50CDK191.00366437
51KSR20.97746071
52SGK30.96149212
53DYRK20.93673316
54DYRK1A0.92982904
55CAMKK10.92499541
56NTRK10.91377398
57PTK2B0.90173936
58CAMK2B0.90014598
59FES0.89967644
60STK38L0.88631991
61FGFR20.88186811
62AKT30.85531998
63STK380.85017261
64FRK0.84976599
65PRPF4B0.84688946
66SGK10.84070030
67CAMKK20.83455802
68TAF10.83364528
69STK110.81717430
70FGR0.78154154
71TGFBR10.78071817
72CCNB10.77356950
73PRKCE0.75648162
74ADRBK10.75437029
75PRKD30.74970897
76VRK10.74254974
77UHMK10.71635103
78PHKG10.70976049
79PHKG20.70976049
80CSNK1G30.70631181
81BRD40.69300917
82RET0.68802291
83CSNK1A1L0.67880361
84CAMK10.67406778
85MAP3K130.65695954
86OXSR10.65647115
87TEC0.64946425
88PLK40.63629295
89PLK30.63106963
90RAF10.62545486
91PRKCH0.62200035
92BRSK20.61721130
93FER0.60950344
94CDK180.60942594
95MKNK20.59722756
96PAK30.59703251
97WNK30.58066248
98CDK150.57049074
99CSNK1D0.56749695
100TXK0.55153231
101MARK20.54525602
102CDK30.54282149
103CDK140.53631403
104CDC70.53500117
105CAMK40.52487744
106YES10.51973845
107RPS6KA20.51144009
108MAPKAPK50.50393218
109STK30.50212768
110NEK60.49962698
111BCR0.49431641
112INSRR0.48859064
113WNK10.48649791
114CSNK1G10.48026417
115WEE10.47135425
116MAPK100.46468270
117CDK11A0.45887024
118CAMK2D0.44546723
119OBSCN0.44405825
120ATM0.44080508
121EIF2AK30.43750326
122ATR0.43709720
123LATS20.43662333
124MAP3K70.43511298
125PRKACA0.43170523
126PRKAA10.43092139
127CHEK20.42746341
128MAPK70.42710564
129RPS6KA30.41566281
130PRKCZ0.41504762
131FYN0.41450400
132SIK30.41213509
133PKN10.39905859
134RPS6KB10.39288217
135TYRO30.39223027
136MAPK120.37998033
137ITK0.37942676
138CDC42BPA0.37658466
139PRKG10.37457351
140PIK3CA0.35439017

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94920469
2Synaptic vesicle cycle_Homo sapiens_hsa047212.77160267
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75942605
4Long-term potentiation_Homo sapiens_hsa047202.64054669
5Circadian entrainment_Homo sapiens_hsa047132.58919182
6GABAergic synapse_Homo sapiens_hsa047272.53837112
7Amphetamine addiction_Homo sapiens_hsa050312.48146178
8Morphine addiction_Homo sapiens_hsa050322.47706288
9Glutamatergic synapse_Homo sapiens_hsa047242.44361881
10Olfactory transduction_Homo sapiens_hsa047402.33912753
11Dopaminergic synapse_Homo sapiens_hsa047282.14802922
12Taste transduction_Homo sapiens_hsa047421.96667983
13Nitrogen metabolism_Homo sapiens_hsa009101.96381360
14Salivary secretion_Homo sapiens_hsa049701.94003583
15Serotonergic synapse_Homo sapiens_hsa047261.91341772
16Basal transcription factors_Homo sapiens_hsa030221.91238184
17Insulin secretion_Homo sapiens_hsa049111.87277571
18Renin secretion_Homo sapiens_hsa049241.81489887
19Long-term depression_Homo sapiens_hsa047301.80530612
20Fanconi anemia pathway_Homo sapiens_hsa034601.80396884
21Cholinergic synapse_Homo sapiens_hsa047251.76360030
22Butanoate metabolism_Homo sapiens_hsa006501.69901125
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69841870
24Linoleic acid metabolism_Homo sapiens_hsa005911.69421394
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68738027
26RNA degradation_Homo sapiens_hsa030181.67654507
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63881322
28Homologous recombination_Homo sapiens_hsa034401.61663639
29Cocaine addiction_Homo sapiens_hsa050301.60865653
30Gastric acid secretion_Homo sapiens_hsa049711.59661633
31Calcium signaling pathway_Homo sapiens_hsa040201.55081647
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54261809
33Selenocompound metabolism_Homo sapiens_hsa004501.54107858
34Oxytocin signaling pathway_Homo sapiens_hsa049211.53066836
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49226305
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46607051
37Ether lipid metabolism_Homo sapiens_hsa005651.46165798
38Collecting duct acid secretion_Homo sapiens_hsa049661.41269734
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37630769
40GnRH signaling pathway_Homo sapiens_hsa049121.36405077
41Axon guidance_Homo sapiens_hsa043601.35177757
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34250036
43Gap junction_Homo sapiens_hsa045401.32082005
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31528802
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31359592
46cAMP signaling pathway_Homo sapiens_hsa040241.30541704
47Phototransduction_Homo sapiens_hsa047441.28462006
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26348140
49Non-homologous end-joining_Homo sapiens_hsa034501.18590653
50Type II diabetes mellitus_Homo sapiens_hsa049301.18409050
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17313179
52Melanogenesis_Homo sapiens_hsa049161.14970196
53Estrogen signaling pathway_Homo sapiens_hsa049151.14742783
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.12440762
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12170235
56ErbB signaling pathway_Homo sapiens_hsa040121.11722613
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11079226
58RNA polymerase_Homo sapiens_hsa030201.08714056
59Glioma_Homo sapiens_hsa052141.06749768
60Propanoate metabolism_Homo sapiens_hsa006401.03597259
61Dorso-ventral axis formation_Homo sapiens_hsa043200.96169351
62ABC transporters_Homo sapiens_hsa020100.95434723
63Protein export_Homo sapiens_hsa030600.92632046
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91118599
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90809201
66One carbon pool by folate_Homo sapiens_hsa006700.89997675
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89585955
68Oocyte meiosis_Homo sapiens_hsa041140.88293194
69Regulation of autophagy_Homo sapiens_hsa041400.88205731
70Vibrio cholerae infection_Homo sapiens_hsa051100.87887061
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86826875
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.86164193
73Choline metabolism in cancer_Homo sapiens_hsa052310.82122316
74Wnt signaling pathway_Homo sapiens_hsa043100.81945614
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81901495
76Tryptophan metabolism_Homo sapiens_hsa003800.81609408
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78559408
78MAPK signaling pathway_Homo sapiens_hsa040100.77474799
79Alcoholism_Homo sapiens_hsa050340.75250857
80Thyroid hormone synthesis_Homo sapiens_hsa049180.74933198
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74621503
82Basal cell carcinoma_Homo sapiens_hsa052170.72817867
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.71262182
84Type I diabetes mellitus_Homo sapiens_hsa049400.70777277
85Colorectal cancer_Homo sapiens_hsa052100.69678277
86Ras signaling pathway_Homo sapiens_hsa040140.69221280
87Dilated cardiomyopathy_Homo sapiens_hsa054140.68484567
88Oxidative phosphorylation_Homo sapiens_hsa001900.67946795
89Pancreatic secretion_Homo sapiens_hsa049720.67706574
90Caffeine metabolism_Homo sapiens_hsa002320.66830922
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66262157
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65135920
93Glycerolipid metabolism_Homo sapiens_hsa005610.63940740
94African trypanosomiasis_Homo sapiens_hsa051430.63481078
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62063217
96Rap1 signaling pathway_Homo sapiens_hsa040150.61931820
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61621493
98Endometrial cancer_Homo sapiens_hsa052130.61296547
99mTOR signaling pathway_Homo sapiens_hsa041500.60168796
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58787606
101Cardiac muscle contraction_Homo sapiens_hsa042600.58389574
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57475917
103Hippo signaling pathway_Homo sapiens_hsa043900.56906655
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.56172140
105Inositol phosphate metabolism_Homo sapiens_hsa005620.56100204
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.56009723
107Glucagon signaling pathway_Homo sapiens_hsa049220.55727891
108Purine metabolism_Homo sapiens_hsa002300.55154393
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.54912891
110Parkinsons disease_Homo sapiens_hsa050120.54584286
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52858277
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52721163
113Peroxisome_Homo sapiens_hsa041460.52563873
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51923181
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50430262
116Nucleotide excision repair_Homo sapiens_hsa034200.49478630
117mRNA surveillance pathway_Homo sapiens_hsa030150.49332270
118Circadian rhythm_Homo sapiens_hsa047100.48578697
119Primary immunodeficiency_Homo sapiens_hsa053400.48506049
120Hedgehog signaling pathway_Homo sapiens_hsa043400.47682735
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46697536
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46554229
123Ovarian steroidogenesis_Homo sapiens_hsa049130.46498843
124VEGF signaling pathway_Homo sapiens_hsa043700.46185506
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.46082472
126Huntingtons disease_Homo sapiens_hsa050160.45834678
127RNA transport_Homo sapiens_hsa030130.45573649
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45004550
129beta-Alanine metabolism_Homo sapiens_hsa004100.44830232
130Renal cell carcinoma_Homo sapiens_hsa052110.43999859
131Melanoma_Homo sapiens_hsa052180.42812714
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42757706
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41457021
134Non-small cell lung cancer_Homo sapiens_hsa052230.41203813
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41019641
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38682992
137Alzheimers disease_Homo sapiens_hsa050100.38212435
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37439285
139T cell receptor signaling pathway_Homo sapiens_hsa046600.35944093
140FoxO signaling pathway_Homo sapiens_hsa040680.34840543
141Retinol metabolism_Homo sapiens_hsa008300.33812683
142Prolactin signaling pathway_Homo sapiens_hsa049170.33811068
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33488220
144Rheumatoid arthritis_Homo sapiens_hsa053230.33399704
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33041485
146Chemokine signaling pathway_Homo sapiens_hsa040620.32611031
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32574164

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