SCAMP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.47286819
2proteasome assembly (GO:0043248)4.93044180
3formation of translation preinitiation complex (GO:0001731)4.74958687
4L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.73956859
5signal peptide processing (GO:0006465)4.54027370
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39802429
7semaphorin-plexin signaling pathway (GO:0071526)4.26519131
8ribosomal small subunit assembly (GO:0000028)4.26437486
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.14643577
10protein deneddylation (GO:0000338)4.11541280
11regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.07946723
12negative regulation of ligase activity (GO:0051352)4.07233240
13negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07233240
14protein retention in ER lumen (GO:0006621)4.05403891
15nucleobase biosynthetic process (GO:0046112)4.04489510
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.03949967
17maturation of SSU-rRNA (GO:0030490)4.02193208
18axonemal dynein complex assembly (GO:0070286)4.01977444
19telomere maintenance via semi-conservative replication (GO:0032201)4.00796584
20purine nucleobase biosynthetic process (GO:0009113)4.00181911
21mannose metabolic process (GO:0006013)3.99132575
22COPI coating of Golgi vesicle (GO:0048205)3.95143741
23Golgi transport vesicle coating (GO:0048200)3.95143741
24positive regulation of histone deacetylation (GO:0031065)3.94977536
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.92517713
26amino acid salvage (GO:0043102)3.92355540
27L-methionine salvage (GO:0071267)3.92355540
28L-methionine biosynthetic process (GO:0071265)3.92355540
29DNA strand elongation involved in DNA replication (GO:0006271)3.92210021
30cullin deneddylation (GO:0010388)3.91778182
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.88187627
32antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.86558260
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.86030437
34regulation of cellular amino acid metabolic process (GO:0006521)3.85327132
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.82028910
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.82028910
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.82028910
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.80510625
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.80510625
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.80124031
41DNA strand elongation (GO:0022616)3.79861357
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.74686904
43termination of RNA polymerase III transcription (GO:0006386)3.74686904
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.69744595
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.69744595
46signal transduction involved in cell cycle checkpoint (GO:0072395)3.67360137
47pseudouridine synthesis (GO:0001522)3.65382251
48endothelial cell chemotaxis (GO:0035767)3.64084013
49cell-cell junction maintenance (GO:0045217)3.59679196
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.57510010
51adhesion of symbiont to host (GO:0044406)3.52778859
52motile cilium assembly (GO:0044458)3.49417626
537-methylguanosine mRNA capping (GO:0006370)3.48520056
54positive regulation of ligase activity (GO:0051351)3.48263891
55telomere maintenance via recombination (GO:0000722)3.46933862
56adhesion of symbiont to host cell (GO:0044650)3.44562585
57virion attachment to host cell (GO:0019062)3.44562585
58ribosome biogenesis (GO:0042254)3.41727433
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.40193328
60rRNA modification (GO:0000154)3.39283385
61regulation of extracellular matrix disassembly (GO:0010715)3.38301173
62ribosome assembly (GO:0042255)3.38187439
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37888473
64RNA capping (GO:0036260)3.36051213
657-methylguanosine RNA capping (GO:0009452)3.36051213
66ribosomal large subunit biogenesis (GO:0042273)3.35648821
67antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.35465763
68basement membrane organization (GO:0071711)3.33825497
69establishment of apical/basal cell polarity (GO:0035089)3.28784826
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.28406732
71protein localization to endosome (GO:0036010)3.23223967
72transcription-coupled nucleotide-excision repair (GO:0006283)3.22538823
73ribonucleoprotein complex biogenesis (GO:0022613)3.22012620
74lung epithelium development (GO:0060428)3.21557925
75transcription from RNA polymerase I promoter (GO:0006360)3.20714770
76regulation of ubiquitin-protein transferase activity (GO:0051438)3.20637903
77DNA replication checkpoint (GO:0000076)3.20086792
78positive regulation of cell cycle arrest (GO:0071158)3.19922561
79GDP-mannose metabolic process (GO:0019673)3.19335299
80methionine biosynthetic process (GO:0009086)3.18663325
81translation (GO:0006412)3.18568342
82cilium or flagellum-dependent cell motility (GO:0001539)3.18151185
83regulation of apoptotic process involved in morphogenesis (GO:1902337)3.17837382
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17125449
85positive regulation of triglyceride biosynthetic process (GO:0010867)3.16798971
86DNA replication initiation (GO:0006270)3.16690613
87spliceosomal snRNP assembly (GO:0000387)3.15914492
88regulation of ligase activity (GO:0051340)3.14526675
89sequestering of actin monomers (GO:0042989)3.14401041
90viral mRNA export from host cell nucleus (GO:0046784)3.12162898
91telomere maintenance via telomere lengthening (GO:0010833)3.11663859
92rRNA processing (GO:0006364)3.08129313
93amyloid precursor protein catabolic process (GO:0042987)3.07388600
94cotranslational protein targeting to membrane (GO:0006613)3.06983282
95negative regulation of cell size (GO:0045792)3.06872024
96termination of RNA polymerase I transcription (GO:0006363)3.05343861
97protein targeting to ER (GO:0045047)3.04115235
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.99816730
99tRNA methylation (GO:0030488)2.98614401
100G1/S transition of mitotic cell cycle (GO:0000082)2.96485281
101cell cycle G1/S phase transition (GO:0044843)2.96485281
102protein localization to endoplasmic reticulum (GO:0070972)2.95657530
103rRNA metabolic process (GO:0016072)2.95118552
104protein heterotrimerization (GO:0070208)2.94239040
105folic acid metabolic process (GO:0046655)2.93989377
106mitotic recombination (GO:0006312)2.93814865
107regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.91390250
108peptidyl-histidine modification (GO:0018202)2.89468875
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.89439397
110vascular endothelial growth factor signaling pathway (GO:0038084)2.88987153
111aspartate family amino acid biosynthetic process (GO:0009067)2.86463470
112folic acid transport (GO:0015884)2.86144473
113ribosomal small subunit biogenesis (GO:0042274)2.86025485
114translational initiation (GO:0006413)2.85039934
115barbed-end actin filament capping (GO:0051016)2.84221811
116establishment of monopolar cell polarity (GO:0061162)2.82587266
117establishment or maintenance of monopolar cell polarity (GO:0061339)2.82587266
118establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82223131
119maturation of 5.8S rRNA (GO:0000460)2.81603716
120tooth mineralization (GO:0034505)2.81397993
121UV protection (GO:0009650)2.80112149
122translational elongation (GO:0006414)2.79553623
123apoptotic process involved in morphogenesis (GO:0060561)2.78769216
124transcription elongation from RNA polymerase I promoter (GO:0006362)2.78762472
125viral transcription (GO:0019083)2.77333651
126translational termination (GO:0006415)2.76981915
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76034989
128desmosome organization (GO:0002934)2.75666669
129negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.75038007
130tRNA aminoacylation (GO:0043039)2.75013146
131amino acid activation (GO:0043038)2.75013146
132type B pancreatic cell proliferation (GO:0044342)2.74878166
133IMP biosynthetic process (GO:0006188)2.74347859
134tRNA aminoacylation for protein translation (GO:0006418)2.73660685
135left/right pattern formation (GO:0060972)2.73607085
136rRNA methylation (GO:0031167)2.73483955
137negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72945191
138nucleobase-containing small molecule interconversion (GO:0015949)2.72803755
139regulation of translation in response to stress (GO:0043555)2.72329369
140hemidesmosome assembly (GO:0031581)2.71682521
141negative regulation of catenin import into nucleus (GO:0035414)2.71277013
142atrioventricular valve morphogenesis (GO:0003181)2.70325882
143protein insertion into membrane (GO:0051205)2.68293520
144cell junction maintenance (GO:0034331)2.63110625
145regulation of early endosome to late endosome transport (GO:2000641)2.62054661
146positive regulation of protein dephosphorylation (GO:0035307)2.61563909
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60488078
148cellular response to virus (GO:0098586)2.58843942
149regulation of histone deacetylation (GO:0031063)2.58368471
150cellular response to pH (GO:0071467)2.56095969
151positive regulation of protein deacetylation (GO:0090312)2.55682487
152skin morphogenesis (GO:0043589)2.53583614
153dermatan sulfate metabolic process (GO:0030205)2.53170034
154positive regulation of CREB transcription factor activity (GO:0032793)2.50950377
155regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49843840
156activation of Rac GTPase activity (GO:0032863)2.49458608
157apoptotic cell clearance (GO:0043277)2.49116240
158positive regulation of fatty acid beta-oxidation (GO:0032000)2.49089876
159lipopolysaccharide biosynthetic process (GO:0009103)2.48086211
160cellular response to exogenous dsRNA (GO:0071360)2.47611833
161vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.47597794
162regulation of extracellular matrix organization (GO:1903053)2.46273813
163positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45080189
164adherens junction assembly (GO:0034333)2.44754504
165regulation of mammary gland epithelial cell proliferation (GO:0033599)2.39977272
166negative regulation of T cell differentiation in thymus (GO:0033085)2.39390726
167proline biosynthetic process (GO:0006561)2.38904541
168cell-substrate junction assembly (GO:0007044)2.38341447
169positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38341022
170regulation of establishment of planar polarity (GO:0090175)2.38045592
171cytoskeletal anchoring at plasma membrane (GO:0007016)2.37534494
172regulation of hydrogen peroxide metabolic process (GO:0010310)2.35971711
173ear development (GO:0043583)2.35871989
174modulation by virus of host morphology or physiology (GO:0019048)2.35088837
175negative regulation of viral release from host cell (GO:1902187)2.33756809
176endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.33481239
177positive regulation of extracellular matrix organization (GO:1903055)2.33112672
178cilium movement (GO:0003341)2.30748361
179cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.27414174
180negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.26900580
181glutathione biosynthetic process (GO:0006750)2.26247855
182cell-substrate adherens junction assembly (GO:0007045)2.26067020
183focal adhesion assembly (GO:0048041)2.26067020
184embryo implantation (GO:0007566)2.25020535
185epithelial cell-cell adhesion (GO:0090136)2.24629507
186regulation of fatty acid beta-oxidation (GO:0031998)2.24594641
187retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.23988218
188regulation of glucose import in response to insulin stimulus (GO:2001273)2.23261633
189vitamin transmembrane transport (GO:0035461)2.22909459
190Rho protein signal transduction (GO:0007266)2.22873779
191membrane protein intracellular domain proteolysis (GO:0031293)2.22150483
192heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.21916947
193modulation by virus of host process (GO:0019054)2.21783217
194negative regulation of fatty acid transport (GO:2000192)2.21050490
195maintenance of protein localization in organelle (GO:0072595)2.20458297
196ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.18651226
197negative regulation of macroautophagy (GO:0016242)2.18221519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.37255561
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.18363438
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.97018442
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.81973214
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70694488
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62407119
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.31254959
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.19086957
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.16890034
10LXR_22292898_ChIP-Seq_THP-1_Human3.16383379
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98868900
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.95207586
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94400510
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.82101241
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79202700
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.60328245
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59697194
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50374041
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48601965
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44512277
21VDR_23849224_ChIP-Seq_CD4+_Human2.33173933
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32069718
23RACK7_27058665_Chip-Seq_MCF-7_Human2.31682475
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26264393
25XRN2_22483619_ChIP-Seq_HELA_Human2.22301103
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22050746
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18566286
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17671903
29DCP1A_22483619_ChIP-Seq_HELA_Human2.15207353
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.15188809
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.12835711
32* P68_20966046_ChIP-Seq_HELA_Human2.11388569
33* GABP_19822575_ChIP-Seq_HepG2_Human2.10932088
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09021803
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08738225
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08429961
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05571780
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04994999
39FOXP3_21729870_ChIP-Seq_TREG_Human2.00676164
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99571839
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99394639
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98582061
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.96215958
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91520485
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.90062886
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84922107
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82686176
48KDM2B_26808549_Chip-Seq_K562_Human1.81518274
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.81014453
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80043697
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79407719
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78946353
53SMC4_20622854_ChIP-Seq_HELA_Human1.77222977
54TP53_22127205_ChIP-Seq_IMR90_Human1.76796595
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.75776964
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.74951257
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69378294
58KDM2B_26808549_Chip-Seq_DND41_Human1.69121291
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.68579002
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68506000
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.64082890
62ZNF263_19887448_ChIP-Seq_K562_Human1.63394371
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.62861548
64TTF2_22483619_ChIP-Seq_HELA_Human1.62575954
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62390006
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60459160
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60216420
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60108248
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60107807
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58946301
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54750288
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54688415
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54010459
74BCOR_27268052_Chip-Seq_Bcells_Human1.53626606
75BCL6_27268052_Chip-Seq_Bcells_Human1.52258696
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51728910
77* MYC_22102868_ChIP-Seq_BL_Human1.51704872
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51461649
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50656213
80CIITA_25753668_ChIP-Seq_RAJI_Human1.50278883
81CREB1_26743006_Chip-Seq_LNCaP_Human1.49980124
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48250085
83CTCF_27219007_Chip-Seq_Bcells_Human1.48104293
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47779277
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47268866
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46971233
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46631732
88TCF7_22412390_ChIP-Seq_EML_Mouse1.45849074
89TP63_22573176_ChIP-Seq_HFKS_Human1.44816639
90DROSHA_22980978_ChIP-Seq_HELA_Human1.44369053
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44005310
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42653274
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41658410
94AR_21909140_ChIP-Seq_LNCAP_Human1.40040039
95* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38658110
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37365372
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36093435
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35230712
99KDM5A_27292631_Chip-Seq_BREAST_Human1.34498886
100ELK1_19687146_ChIP-ChIP_HELA_Human1.32402031
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31394614
102E2F1_20622854_ChIP-Seq_HELA_Human1.31216278
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31090252
104CTCF_20526341_ChIP-Seq_ESCs_Human1.31003462
105PHF8_20622854_ChIP-Seq_HELA_Human1.29886583
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29308123
107VDR_24763502_ChIP-Seq_THP-1_Human1.28812627
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.28069551
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.25609482
110FOXM1_23109430_ChIP-Seq_U2OS_Human1.25212186
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24794089
112TFEB_21752829_ChIP-Seq_HELA_Human1.24545396
113* RARB_24833708_ChIP-Seq_LIVER_Mouse1.23629344
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23478457
115SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21297892
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.20087917
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20086269
118SPI1_23547873_ChIP-Seq_NB4_Human1.19015547
119TP53_23651856_ChIP-Seq_MEFs_Mouse1.17696710
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16819017
121ATF3_27146783_Chip-Seq_COLON_Human1.16100204
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15174416
123SA1_27219007_Chip-Seq_Bcells_Human1.15044699
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15035788
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14967897
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14445528
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.13995879
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.13733947
129TET1_21490601_ChIP-Seq_MESCs_Mouse1.13695737
130NOTCH1_21737748_ChIP-Seq_TLL_Human1.12620493
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12452367
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11916871
133YY1_22570637_ChIP-Seq_MALME-3M_Human1.11632084
134* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11602546
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11582755
136PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10943614
137IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09794676
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09649198
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09634977
140TRIM28_21343339_ChIP-Seq_HEK293_Human1.08952055
141CTCF_26484167_Chip-Seq_Bcells_Mouse1.08738639
142P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08223764
143EGR1_19374776_ChIP-ChIP_THP-1_Human1.07100387
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06836766
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06648353
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06484730
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06213963
148KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06133497
149RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05864504
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05103093
151MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04624261
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04409563
153TP53_20018659_ChIP-ChIP_R1E_Mouse1.04008866
154ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03639857
155KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03335364
156PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01543072
157* IRF8_22096565_ChIP-ChIP_GC-B_Human1.01489618
158ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01361563
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01355604
160MAF_26560356_Chip-Seq_TH2_Human1.01197191
161* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01045649
162E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00332472
163PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00277614
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00273488
165VDR_21846776_ChIP-Seq_THP-1_Human1.00164969
166GATA1_19941827_ChIP-Seq_MEL_Mouse1.00031653
167OCT4_19829295_ChIP-Seq_ESCs_Human0.98243511
168SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97810173
169STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97712548
170SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97391809
171SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97382810
172TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97149600
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95587270
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94136261
175* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94023961
176IRF8_21731497_ChIP-ChIP_J774_Mouse0.92739371
177CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92646433
178STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91588838
179* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90751603
180POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89640846
181TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88176402
182ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87602574
183DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86362601
184ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85488332
185CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84084038
186CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84025844
187* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83856846
188EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83376484
189TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82974561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.76485468
2MP0003705_abnormal_hypodermis_morpholog4.29376332
3MP0004858_abnormal_nervous_system3.89749488
4MP0004957_abnormal_blastocyst_morpholog3.85576989
5MP0003172_abnormal_lysosome_physiology3.14734229
6MP0003111_abnormal_nucleus_morphology3.01778114
7MP0005257_abnormal_intraocular_pressure2.98444234
8MP0002653_abnormal_ependyma_morphology2.88121616
9MP0003077_abnormal_cell_cycle2.78249450
10MP0010094_abnormal_chromosome_stability2.69283227
11MP0002396_abnormal_hematopoietic_system2.51937829
12MP0003763_abnormal_thymus_physiology2.48032343
13MP0008007_abnormal_cellular_replicative2.42334661
14MP0008058_abnormal_DNA_repair2.41701923
15MP0009333_abnormal_splenocyte_physiolog2.35815327
16MP0006054_spinal_hemorrhage2.32024744
17MP0001849_ear_inflammation2.26382478
18MP0003329_amyloid_beta_deposits2.25105175
19MP0005671_abnormal_response_to2.24744284
20MP0009840_abnormal_foam_cell2.20911096
21MP0003806_abnormal_nucleotide_metabolis2.16135298
22MP0008932_abnormal_embryonic_tissue2.12358832
23MP0002249_abnormal_larynx_morphology2.07528757
24MP0001958_emphysema2.02899484
25MP0003186_abnormal_redox_activity2.01512675
26MP0003123_paternal_imprinting1.95855147
27MP0002254_reproductive_system_inflammat1.92535292
28MP0000490_abnormal_crypts_of1.92286589
29MP0009384_cardiac_valve_regurgitation1.91762623
30MP0009278_abnormal_bone_marrow1.90064154
31MP0005076_abnormal_cell_differentiation1.87719428
32MP0001348_abnormal_lacrimal_gland1.80345395
33MP0005623_abnormal_meninges_morphology1.73744042
34MP0004272_abnormal_basement_membrane1.66866497
35MP0003786_premature_aging1.65385325
36MP0002132_abnormal_respiratory_system1.65077592
37MP0008875_abnormal_xenobiotic_pharmacok1.61747478
38MP0000678_abnormal_parathyroid_gland1.60477873
39MP0001730_embryonic_growth_arrest1.59125070
40MP0009780_abnormal_chondrocyte_physiolo1.58393147
41MP0000858_altered_metastatic_potential1.58091251
42MP0001835_abnormal_antigen_presentation1.56944023
43MP0008057_abnormal_DNA_replication1.54191670
44MP0005508_abnormal_skeleton_morphology1.52819295
45MP0009785_altered_susceptibility_to1.46953917
46MP0005023_abnormal_wound_healing1.46590305
47MP0002398_abnormal_bone_marrow1.46565445
48MP0010352_gastrointestinal_tract_polyps1.46430217
49MP0005409_darkened_coat_color1.45756556
50MP0002722_abnormal_immune_system1.43322422
51MP0001542_abnormal_bone_strength1.42683311
52MP0000604_amyloidosis1.42440251
53MP0004133_heterotaxia1.42318186
54MP0000689_abnormal_spleen_morphology1.40907226
55MP0000350_abnormal_cell_proliferation1.40664909
56MP0002019_abnormal_tumor_incidence1.40358484
57MP0003436_decreased_susceptibility_to1.39522186
58MP0008438_abnormal_cutaneous_collagen1.38997325
59MP0005075_abnormal_melanosome_morpholog1.38431437
60MP0010030_abnormal_orbit_morphology1.37870383
61MP0003718_maternal_effect1.37728662
62MP0000566_synostosis1.35854196
63MP0000313_abnormal_cell_death1.33462158
64MP0002429_abnormal_blood_cell1.32956057
65MP0002933_joint_inflammation1.32520111
66MP0002420_abnormal_adaptive_immunity1.31976956
67MP0000003_abnormal_adipose_tissue1.31951888
68MP0003566_abnormal_cell_adhesion1.30052774
69MP0003183_abnormal_peptide_metabolism1.29904768
70MP0000716_abnormal_immune_system1.29771541
71MP0001819_abnormal_immune_cell1.29257030
72MP0003656_abnormal_erythrocyte_physiolo1.28815818
73MP0000681_abnormal_thyroid_gland1.28795176
74MP0003075_altered_response_to1.28380933
75MP0005000_abnormal_immune_tolerance1.27657916
76MP0005397_hematopoietic_system_phenotyp1.27434503
77MP0001545_abnormal_hematopoietic_system1.27434503
78MP0010155_abnormal_intestine_physiology1.27016016
79MP0002060_abnormal_skin_morphology1.26267683
80MP0005025_abnormal_response_to1.23171454
81MP0005058_abnormal_lysosome_morphology1.21336326
82MP0000767_abnormal_smooth_muscle1.21179331
83MP0003091_abnormal_cell_migration1.19847345
84MP0000534_abnormal_ureter_morphology1.19731086
85MP0004947_skin_inflammation1.18784185
86MP0002452_abnormal_antigen_presenting1.18441213
87MP0000703_abnormal_thymus_morphology1.18422877
88MP0003634_abnormal_glial_cell1.17268687
89MP0005083_abnormal_biliary_tract1.16888451
90MP0003453_abnormal_keratinocyte_physiol1.16550393
91MP0006082_CNS_inflammation1.15589598
92MP0002080_prenatal_lethality1.14945649
93MP0000358_abnormal_cell_content/1.14655830
94MP0002877_abnormal_melanocyte_morpholog1.13889210
95MP0002723_abnormal_immune_serum1.12913529
96MP0004264_abnormal_extraembryonic_tissu1.11446680
97MP0000465_gastrointestinal_hemorrhage1.10497723
98MP0001533_abnormal_skeleton_physiology1.09611123
99MP0003191_abnormal_cellular_cholesterol1.09562814
100MP0001800_abnormal_humoral_immune1.08723460
101MP0005595_abnormal_vascular_smooth1.08251020
102MP0002896_abnormal_bone_mineralization1.07003604
103MP0001697_abnormal_embryo_size1.06705361
104MP0010368_abnormal_lymphatic_system1.06645317
105MP0003942_abnormal_urinary_system1.06608718
106MP0002419_abnormal_innate_immunity1.06536560
107MP0002405_respiratory_system_inflammati1.06410910
108MP0003724_increased_susceptibility_to1.06213444
109MP0003866_abnormal_defecation1.05872460
110MP0001243_abnormal_dermal_layer1.05118889
111MP0000685_abnormal_immune_system1.03281910
112MP0002148_abnormal_hypersensitivity_rea1.00412634
113MP0001764_abnormal_homeostasis1.00374585
114MP0003984_embryonic_growth_retardation0.99841337
115MP0003879_abnormal_hair_cell0.99719346
116MP0000343_altered_response_to0.99544342
117MP0004043_abnormal_pH_regulation0.99461866
118MP0000613_abnormal_salivary_gland0.97942849
119MP0001502_abnormal_circadian_rhythm0.97358538
120MP0004808_abnormal_hematopoietic_stem0.97213269
121MP0000013_abnormal_adipose_tissue0.96600073
122MP0003045_fibrosis0.94965942
123MP0001672_abnormal_embryogenesis/_devel0.94328945
124MP0005380_embryogenesis_phenotype0.94328945
125MP0002088_abnormal_embryonic_growth/wei0.94308383
126MP0005670_abnormal_white_adipose0.93734172
127MP0002998_abnormal_bone_remodeling0.93320796
128MP0003283_abnormal_digestive_organ0.93147498
129MP0006036_abnormal_mitochondrial_physio0.93045422
130MP0005503_abnormal_tendon_morphology0.92224123
131MP0001845_abnormal_inflammatory_respons0.91812688
132MP0009697_abnormal_copulation0.90047969
133MP0005360_urolithiasis0.89660453
134MP0002098_abnormal_vibrissa_morphology0.87820542
135MP0004233_abnormal_muscle_weight0.87476402
136MP0000163_abnormal_cartilage_morphology0.87364208
137MP0001853_heart_inflammation0.87285421
138MP0003279_aneurysm0.86982290
139MP0005451_abnormal_body_composition0.86492182
140MP0000467_abnormal_esophagus_morphology0.85394732
141MP0000477_abnormal_intestine_morphology0.84220971
142MP0002116_abnormal_craniofacial_bone0.83326243
143MP0001270_distended_abdomen0.83322839
144MP0003567_abnormal_fetal_cardiomyocyte0.81569353
145MP0002086_abnormal_extraembryonic_tissu0.80777496
146MP0000733_abnormal_muscle_development0.80334096
147MP0002932_abnormal_joint_morphology0.79869221
148MP0005390_skeleton_phenotype0.79798853
149MP0001790_abnormal_immune_system0.79776745
150MP0005387_immune_system_phenotype0.79776745
151MP0002160_abnormal_reproductive_system0.78850004
152MP0003303_peritoneal_inflammation0.77371933
153MP0008469_abnormal_protein_level0.76944582
154MP0005384_cellular_phenotype0.76560410
155MP0009053_abnormal_anal_canal0.76533380
156MP0002089_abnormal_postnatal_growth/wei0.75489812
157MP0004510_myositis0.75433983
158MP0004147_increased_porphyrin_level0.75017093
159MP0005165_increased_susceptibility_to0.73169942
160MP0002168_other_aberrant_phenotype0.72350112
161MP0000538_abnormal_urinary_bladder0.71936659
162MP0002295_abnormal_pulmonary_circulatio0.71316551
163MP0005377_hearing/vestibular/ear_phenot0.70906385
164MP0003878_abnormal_ear_physiology0.70906385
165MP0005621_abnormal_cell_physiology0.70075056
166MP0001756_abnormal_urination0.68937560
167MP0005275_abnormal_skin_tensile0.67859387
168MP0000598_abnormal_liver_morphology0.66512455
169MP0003300_gastrointestinal_ulcer0.66365593
170MP0002113_abnormal_skeleton_development0.66358246
171MP0002085_abnormal_embryonic_tissue0.66297518
172MP0001873_stomach_inflammation0.66120019
173MP0002282_abnormal_trachea_morphology0.66064274
174MP0003115_abnormal_respiratory_system0.65522615
175MP0008260_abnormal_autophagy0.65401561
176MP0010307_abnormal_tumor_latency0.64899552
177MP0001765_abnormal_ion_homeostasis0.63483581
178MP0001216_abnormal_epidermal_layer0.63250628
179MP0000537_abnormal_urethra_morphology0.63040401
180MP0005381_digestive/alimentary_phenotyp0.62124118
181MP0000750_abnormal_muscle_regeneration0.61067954
182MP0005167_abnormal_blood-brain_barrier0.60848306
183MP0004381_abnormal_hair_follicle0.59923010

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.23543333
2Type I transferrin isoform profile (HP:0003642)3.89326894
3Increased cerebral lipofuscin (HP:0011813)3.86532828
4Abnormal number of erythroid precursors (HP:0012131)3.74693684
5Degeneration of anterior horn cells (HP:0002398)3.73526010
6Abnormality of the anterior horn cell (HP:0006802)3.73526010
7Obstructive sleep apnea (HP:0002870)3.65627303
8Hyperacusis (HP:0010780)3.58657391
9Abnormality of cells of the erythroid lineage (HP:0012130)3.48276287
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.47777848
11Rough bone trabeculation (HP:0100670)3.47359696
12Dysostosis multiplex (HP:0000943)3.46080790
13Cervical subluxation (HP:0003308)3.38964033
14Abnormality of the nasal mucosa (HP:0000433)3.29145083
15Abnormality of polysaccharide metabolism (HP:0011012)3.26883854
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.26883854
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.26883854
18Aplastic anemia (HP:0001915)3.25368577
19Birth length less than 3rd percentile (HP:0003561)3.20873366
20Elevated erythrocyte sedimentation rate (HP:0003565)3.16978116
21J-shaped sella turcica (HP:0002680)3.13300508
22Mucopolysacchariduria (HP:0008155)3.10774930
23Urinary glycosaminoglycan excretion (HP:0003541)3.10774930
24Nasal polyposis (HP:0100582)3.09112856
25Abnormality of the umbilical cord (HP:0010881)3.05151959
26Abnormality of glycolipid metabolism (HP:0010969)3.03139853
27Abnormality of liposaccharide metabolism (HP:0010968)3.03139853
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.03139853
29Abnormal respiratory epithelium morphology (HP:0012253)3.02282024
30Abnormal respiratory motile cilium morphology (HP:0005938)3.02282024
31Abnormal protein glycosylation (HP:0012346)3.00333773
32Abnormal glycosylation (HP:0012345)3.00333773
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.00333773
34Abnormal protein N-linked glycosylation (HP:0012347)3.00333773
35Distal upper limb amyotrophy (HP:0007149)3.00318930
36Upper limb amyotrophy (HP:0009129)3.00318930
37Hepatocellular necrosis (HP:0001404)2.98663836
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97484638
39Shallow orbits (HP:0000586)2.95629013
40Stridor (HP:0010307)2.94467973
41Hepatic necrosis (HP:0002605)2.93608032
42Microretrognathia (HP:0000308)2.88984979
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85042322
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85042322
45Carpal bone hypoplasia (HP:0001498)2.83387790
46Oral leukoplakia (HP:0002745)2.82654927
47Breast hypoplasia (HP:0003187)2.82627911
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.82394965
49Absent/shortened dynein arms (HP:0200106)2.82394965
50Broad face (HP:0000283)2.80699138
51Trismus (HP:0000211)2.80464032
52Reticulocytopenia (HP:0001896)2.77842345
53Microvesicular hepatic steatosis (HP:0001414)2.75900752
54Severe combined immunodeficiency (HP:0004430)2.73580942
55Irregular epiphyses (HP:0010582)2.73385306
56Hypoplasia of the thymus (HP:0000778)2.71378522
57Type 2 muscle fiber atrophy (HP:0003554)2.69120633
58Atelectasis (HP:0100750)2.67770629
59Muscle fiber atrophy (HP:0100295)2.61844341
60Hand muscle atrophy (HP:0009130)2.60858347
61Increased serum pyruvate (HP:0003542)2.60543287
62Abnormality of glycolysis (HP:0004366)2.60543287
63Prolonged neonatal jaundice (HP:0006579)2.58877124
64Bladder diverticulum (HP:0000015)2.56909094
65Combined immunodeficiency (HP:0005387)2.56034883
66Atrophy/Degeneration involving motor neurons (HP:0007373)2.54255732
67Abnormal trabecular bone morphology (HP:0100671)2.49698450
68Vertebral compression fractures (HP:0002953)2.49214125
69Increased serum lactate (HP:0002151)2.47932846
70Long toe (HP:0010511)2.45940329
71IgM deficiency (HP:0002850)2.45711916
72Bronchomalacia (HP:0002780)2.44959876
73Multiple enchondromatosis (HP:0005701)2.42277522
74Reduced antithrombin III activity (HP:0001976)2.41671875
75Cerebral aneurysm (HP:0004944)2.41406231
76Abnormal respiratory motile cilium physiology (HP:0012261)2.38906764
77Abnormal ciliary motility (HP:0012262)2.36943610
78Broad metatarsal (HP:0001783)2.35173854
79Nonimmune hydrops fetalis (HP:0001790)2.33917310
80Petechiae (HP:0000967)2.33462734
81Selective tooth agenesis (HP:0001592)2.31686911
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30118419
83Stillbirth (HP:0003826)2.30088815
84CNS hypomyelination (HP:0003429)2.29185034
85Sparse eyelashes (HP:0000653)2.29141327
86Ulnar bowing (HP:0003031)2.27352280
8711 pairs of ribs (HP:0000878)2.27101943
88Premature graying of hair (HP:0002216)2.26542800
89Achilles tendon contracture (HP:0001771)2.23450007
90Recurrent bronchitis (HP:0002837)2.19897346
91Fragile skin (HP:0001030)2.19729787
92Poor head control (HP:0002421)2.18864621
93Slender long bone (HP:0003100)2.18688127
94Blue sclerae (HP:0000592)2.18178581
95Patent foramen ovale (HP:0001655)2.16478213
96Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.16178614
97Vacuolated lymphocytes (HP:0001922)2.14861754
98Abnormality of the distal phalanges of the toes (HP:0010182)2.14712665
99Abnormality of the thoracic spine (HP:0100711)2.13243059
100Atrophic scars (HP:0001075)2.12513685
101Secondary amenorrhea (HP:0000869)2.12009713
102Nuclear cataract (HP:0100018)2.10766655
103Amniotic constriction ring (HP:0009775)2.10444497
104Abnormality of placental membranes (HP:0011409)2.10444497
105Short femoral neck (HP:0100864)2.10417757
106Abnormality of the heme biosynthetic pathway (HP:0010472)2.09901671
107Genu recurvatum (HP:0002816)2.09789960
108IgG deficiency (HP:0004315)2.09495977
109Abnormality of dentin (HP:0010299)2.09147012
110Spinal rigidity (HP:0003306)2.08892405
111Thrombocytosis (HP:0001894)2.08658436
112Hypoplasia of the odontoid process (HP:0003311)2.07929782
113Neurofibrillary tangles (HP:0002185)2.07565253
114Pancytopenia (HP:0001876)2.06663879
115Insomnia (HP:0100785)2.06663812
116Hemorrhage of the eye (HP:0011885)2.06045435
117Abnormalities of placenta or umbilical cord (HP:0001194)2.05408874
118Ankle contracture (HP:0006466)2.01449709
119Short nail (HP:0001799)2.01425163
120Flat capital femoral epiphysis (HP:0003370)2.00678178
121Abnormality of the odontoid process (HP:0003310)1.99896298
122Megaloblastic anemia (HP:0001889)1.98705045
123Mesangial abnormality (HP:0001966)1.98305860
124Emotional lability (HP:0000712)1.97714085
125Beaking of vertebral bodies (HP:0004568)1.97398570
126Disproportionate tall stature (HP:0001519)1.97351076
127Increased CSF lactate (HP:0002490)1.97233456
128Protrusio acetabuli (HP:0003179)1.96606691
129Coxa vara (HP:0002812)1.96198152
130Personality changes (HP:0000751)1.96049104
131Bone marrow hypocellularity (HP:0005528)1.94724686
132Progressive muscle weakness (HP:0003323)1.94676557
133Mitochondrial inheritance (HP:0001427)1.94582727
134CNS demyelination (HP:0007305)1.93157623
135Breech presentation (HP:0001623)1.92700002
136Abnormality of the Achilles tendon (HP:0005109)1.92230102
137Thoracic kyphosis (HP:0002942)1.91982147
138Natal tooth (HP:0000695)1.91756057
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.91254043
140Tongue fasciculations (HP:0001308)1.89684015
141Flat acetabular roof (HP:0003180)1.89671607
142Broad distal phalanx of finger (HP:0009836)1.88960409
143Mitral regurgitation (HP:0001653)1.88331330
144Lymphoma (HP:0002665)1.87946755
145Elfin facies (HP:0004428)1.87712031
146Macrocytic anemia (HP:0001972)1.87103867
147Congenital glaucoma (HP:0001087)1.87099705
148Loss of speech (HP:0002371)1.85285856
149Rhinitis (HP:0012384)1.85274983
150T lymphocytopenia (HP:0005403)1.85241553
151Postnatal microcephaly (HP:0005484)1.83075916
152Joint stiffness (HP:0001387)1.81955474
153Bowing of the arm (HP:0006488)1.81545114
154Bowed forearm bones (HP:0003956)1.81545114
155Patellar aplasia (HP:0006443)1.80270099
156Absent thumb (HP:0009777)1.79882440
1573-Methylglutaconic aciduria (HP:0003535)1.79880486
158Premature skin wrinkling (HP:0100678)1.79678058
159Testicular atrophy (HP:0000029)1.79485048
160Long palpebral fissure (HP:0000637)1.78828061
161Entropion (HP:0000621)1.77554560
162Premature rupture of membranes (HP:0001788)1.76545350
163Biconcave vertebral bodies (HP:0004586)1.76523498
164Deformed sella turcica (HP:0002681)1.76209897
165Flattened epiphyses (HP:0003071)1.76191084
166Generalized amyotrophy (HP:0003700)1.75794858
167Myositis (HP:0100614)1.75728504
168Turricephaly (HP:0000262)1.75537274
169Premature ovarian failure (HP:0008209)1.75191550
170Ovoid vertebral bodies (HP:0003300)1.74967589
171Hypoventilation (HP:0002791)1.74596395
172Aplasia/Hypoplasia of the patella (HP:0006498)1.72797240
173Pallor (HP:0000980)1.71988608
174Emphysema (HP:0002097)1.70883297
175Aortic regurgitation (HP:0001659)1.70320114
176Death in infancy (HP:0001522)1.70162883
177Glossoptosis (HP:0000162)1.70078542
178Renal duplication (HP:0000075)1.69985001
179Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69176037
180Vascular tortuosity (HP:0004948)1.69052877
181Absent epiphyses (HP:0010577)1.68805854
182Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68805854
183Aneurysm (HP:0002617)1.67582139
184Renovascular hypertension (HP:0100817)1.67570709
185Short palpebral fissure (HP:0012745)1.67049009
186Aplasia/hypoplasia of the femur (HP:0005613)1.66032662
187Cerebral inclusion bodies (HP:0100314)1.65555954
188Clumsiness (HP:0002312)1.64699838
189Overriding aorta (HP:0002623)1.64326987
190Supranuclear gaze palsy (HP:0000605)1.62444279
191Elbow flexion contracture (HP:0002987)1.61589553
192Chronic bronchitis (HP:0004469)1.59553612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.66310017
2NME24.40730550
3EIF2AK13.86476530
4STK163.60665684
5SIK13.58062138
6KDR3.34896568
7SMG13.09249857
8ICK3.01921036
9TESK22.99316701
10WEE12.69312859
11EIF2AK32.62217470
12MAPK152.47900327
13PIM22.46178230
14TSSK62.20536961
15TESK12.08146492
16EEF2K2.07510931
17PRKD32.03383891
18PRKD22.01445705
19MAP4K11.98749693
20EPHA21.95786957
21ERN11.94721755
22ZAP701.79998928
23VRK11.74421013
24BCKDK1.72674209
25RIPK11.61554878
26NME11.59784338
27PLK41.52817995
28MAP3K111.41636977
29CDC42BPA1.40261469
30BRSK21.39511009
31ACVR1B1.38986524
32CDK121.38467508
33EPHB11.38287847
34RPS6KA41.37457548
35PTK61.34587342
36PTK21.34253172
37HIPK21.33986368
38LMTK21.31694637
39TXK1.31141968
40RPS6KA21.28566999
41ZAK1.28211852
42SRPK11.26366392
43EPHB21.25954791
44SIK21.25530753
45PKN21.24712556
46PAK41.22410183
47DDR21.20026832
48MARK21.18823921
49PASK1.18008890
50LIMK11.17809715
51PLK11.17797746
52IRAK31.17491306
53AURKA1.14764819
54NEK91.12996112
55MST1R1.10050193
56PLK31.09746769
57RPS6KB21.09674287
58CAMK1D1.09296648
59NTRK11.05200508
60FGFR41.04468082
61MTOR1.03425362
62AURKB1.00777197
63STK38L0.99242510
64STK380.97511636
65TTK0.96932098
66FLT30.96652156
67AKT30.96623847
68PDGFRA0.94971772
69CDK70.92100623
70TLK10.91741410
71MAP3K30.89775032
72TNK20.89471490
73STK100.89346570
74MST40.87520329
75SCYL20.87077315
76BRAF0.86430045
77PRPF4B0.85961059
78PAK10.85049415
79TEC0.84863822
80BRSK10.84450161
81BLK0.83716291
82MAP3K80.78200121
83CHUK0.76958176
84DYRK30.76831707
85BMX0.75450988
86ATR0.75431534
87CDC70.75056611
88TYRO30.74961517
89RPS6KA60.74224029
90NEK20.73691417
91PDPK10.73330504
92LRRK20.72887900
93RPS6KC10.71731802
94RPS6KL10.71731802
95NEK10.71638356
96MAP2K20.71461336
97MET0.69784342
98CAMKK10.69359478
99CLK10.68221867
100TAOK20.68053033
101ILK0.67447104
102TTN0.67399153
103IRAK40.67033887
104MYLK0.67005860
105BTK0.66710104
106JAK30.65444704
107PRKCI0.64500559
108PTK2B0.63784390
109KIT0.63705397
110CSNK2A10.63504230
111CDK80.63475620
112MAP3K10.62466982
113MAP2K30.59541898
114TBK10.58825727
115VRK20.56483988
116DAPK20.56219490
117MAP3K130.54464640
118EIF2AK20.53673129
119MKNK10.53283828
120SIK30.52670294
121DAPK30.52580014
122ARAF0.52545871
123CSNK2A20.51204212
124DYRK20.50432240
125MAPK110.49521646
126CHEK20.49477392
127STK240.49384417
128WNK40.49265246
129TGFBR10.49225928
130TGFBR20.48963493
131IKBKB0.48051243
132MAPKAPK30.47086914
133PIM10.47003354
134LYN0.46655525
135TRIB30.46648039
136ABL20.46467432
137PRKCH0.46386425
138CAMK1G0.45912454
139MAPKAPK20.45295602
140TAOK10.44743478
141MAP2K60.43663040
142PRKD10.43560783
143PRKG20.43521481
144MAP3K120.41909026
145IRAK10.40396642
146IKBKE0.40278022
147CCNB10.40205803
148GRK10.39663236
149MAPK70.39144146
150LATS20.37246846
151SYK0.37173798
152MAP3K70.35277383
153PAK20.35023952
154GRK60.34673487
155CDK40.33471245
156PRKCD0.32377286
157CHEK10.32077340
158IRAK20.31164439
159ADRBK10.30925278
160CDK90.30429658
161MAP2K10.30294953
162CAMK2G0.28390180
163MAPKAPK50.27296742
164DYRK1B0.27163648

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.84472830
2DNA replication_Homo sapiens_hsa030303.88378816
3RNA polymerase_Homo sapiens_hsa030203.59513080
4Ribosome_Homo sapiens_hsa030103.14885989
5Mismatch repair_Homo sapiens_hsa034303.07755069
6Protein export_Homo sapiens_hsa030603.04511979
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98942330
8Base excision repair_Homo sapiens_hsa034102.71375511
9Pyrimidine metabolism_Homo sapiens_hsa002402.59909314
10Nucleotide excision repair_Homo sapiens_hsa034202.50460147
11Spliceosome_Homo sapiens_hsa030402.41330054
12Notch signaling pathway_Homo sapiens_hsa043302.36441715
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34974931
14RNA transport_Homo sapiens_hsa030132.19839213
15Bladder cancer_Homo sapiens_hsa052191.97131068
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.93889926
17Homologous recombination_Homo sapiens_hsa034401.88705654
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.88107392
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74286382
20Prion diseases_Homo sapiens_hsa050201.74045025
21Basal transcription factors_Homo sapiens_hsa030221.70245582
22Other glycan degradation_Homo sapiens_hsa005111.69438135
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67728505
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67696826
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.64223212
26Cell cycle_Homo sapiens_hsa041101.60176232
27One carbon pool by folate_Homo sapiens_hsa006701.54355945
28Sulfur relay system_Homo sapiens_hsa041221.46634594
29VEGF signaling pathway_Homo sapiens_hsa043701.42524633
30Folate biosynthesis_Homo sapiens_hsa007901.40126454
31ECM-receptor interaction_Homo sapiens_hsa045121.39555918
32Antigen processing and presentation_Homo sapiens_hsa046121.39087299
33Primary immunodeficiency_Homo sapiens_hsa053401.38569456
34Purine metabolism_Homo sapiens_hsa002301.32395035
35RNA degradation_Homo sapiens_hsa030181.28675263
36Pentose phosphate pathway_Homo sapiens_hsa000301.27950223
37N-Glycan biosynthesis_Homo sapiens_hsa005101.27908365
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26562641
39Phenylalanine metabolism_Homo sapiens_hsa003601.18186890
40Histidine metabolism_Homo sapiens_hsa003401.17392899
41Non-homologous end-joining_Homo sapiens_hsa034501.15733320
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14592870
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13739122
44Vitamin B6 metabolism_Homo sapiens_hsa007501.11637228
45Acute myeloid leukemia_Homo sapiens_hsa052211.10904733
46Epstein-Barr virus infection_Homo sapiens_hsa051691.08915805
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07482689
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07335096
49p53 signaling pathway_Homo sapiens_hsa041151.07062008
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05807617
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05636837
52Focal adhesion_Homo sapiens_hsa045101.04468558
53TNF signaling pathway_Homo sapiens_hsa046681.03782331
54Legionellosis_Homo sapiens_hsa051341.01650021
55Galactose metabolism_Homo sapiens_hsa000521.00424701
56Hepatitis C_Homo sapiens_hsa051600.96143334
57Endocytosis_Homo sapiens_hsa041440.94973258
58Synaptic vesicle cycle_Homo sapiens_hsa047210.93036172
59Lysosome_Homo sapiens_hsa041420.92370538
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92289660
61Axon guidance_Homo sapiens_hsa043600.92132675
62Biosynthesis of amino acids_Homo sapiens_hsa012300.89769327
63Chronic myeloid leukemia_Homo sapiens_hsa052200.89150963
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.88192337
65ABC transporters_Homo sapiens_hsa020100.87884407
66Glutathione metabolism_Homo sapiens_hsa004800.87823592
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.87208506
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.86996912
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85371916
70Parkinsons disease_Homo sapiens_hsa050120.84727829
71Fanconi anemia pathway_Homo sapiens_hsa034600.83515434
72Basal cell carcinoma_Homo sapiens_hsa052170.83193283
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82263503
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81724483
75GnRH signaling pathway_Homo sapiens_hsa049120.81718180
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81642022
77Oxidative phosphorylation_Homo sapiens_hsa001900.79184529
78Estrogen signaling pathway_Homo sapiens_hsa049150.77120149
79Fructose and mannose metabolism_Homo sapiens_hsa000510.76207229
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.75903352
81Collecting duct acid secretion_Homo sapiens_hsa049660.75164841
82Shigellosis_Homo sapiens_hsa051310.74057479
83Amoebiasis_Homo sapiens_hsa051460.73684178
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73632008
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.73051604
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72849410
87Cocaine addiction_Homo sapiens_hsa050300.72825772
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.72706853
89Toxoplasmosis_Homo sapiens_hsa051450.69465945
90Hematopoietic cell lineage_Homo sapiens_hsa046400.69246644
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.68950176
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66103002
93Selenocompound metabolism_Homo sapiens_hsa004500.65422084
94Huntingtons disease_Homo sapiens_hsa050160.64169760
95Carbon metabolism_Homo sapiens_hsa012000.63647686
96Osteoclast differentiation_Homo sapiens_hsa043800.63441996
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63373645
98Proteoglycans in cancer_Homo sapiens_hsa052050.63001999
99Lysine degradation_Homo sapiens_hsa003100.62910022
100Tyrosine metabolism_Homo sapiens_hsa003500.60547229
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60413696
102Arachidonic acid metabolism_Homo sapiens_hsa005900.60367242
103B cell receptor signaling pathway_Homo sapiens_hsa046620.60316376
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60244350
105Thyroid cancer_Homo sapiens_hsa052160.60242967
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60180035
107Insulin resistance_Homo sapiens_hsa049310.59605500
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.59236977
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59187324
110AMPK signaling pathway_Homo sapiens_hsa041520.59083317
111Choline metabolism in cancer_Homo sapiens_hsa052310.59075561
112Sphingolipid metabolism_Homo sapiens_hsa006000.59025980
113Herpes simplex infection_Homo sapiens_hsa051680.58785262
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58755577
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56805172
116Apoptosis_Homo sapiens_hsa042100.55922431
117Measles_Homo sapiens_hsa051620.55519840
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54459865
119Salivary secretion_Homo sapiens_hsa049700.54349824
120Hippo signaling pathway_Homo sapiens_hsa043900.53787817
121Melanogenesis_Homo sapiens_hsa049160.53756771
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53534969
123mRNA surveillance pathway_Homo sapiens_hsa030150.52949505
124HTLV-I infection_Homo sapiens_hsa051660.52439909
125Non-small cell lung cancer_Homo sapiens_hsa052230.52206320
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52180450
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51863036
128Rheumatoid arthritis_Homo sapiens_hsa053230.51790992
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.51739640
130MAPK signaling pathway_Homo sapiens_hsa040100.51506581
131Metabolic pathways_Homo sapiens_hsa011000.50989914
132Tuberculosis_Homo sapiens_hsa051520.50932250
133Pertussis_Homo sapiens_hsa051330.50156559
134Bile secretion_Homo sapiens_hsa049760.49974982
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49967537
136mTOR signaling pathway_Homo sapiens_hsa041500.48961964
137Endometrial cancer_Homo sapiens_hsa052130.48746715
138ErbB signaling pathway_Homo sapiens_hsa040120.46955260
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46740676
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46513041
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45267949
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44592191
143Phagosome_Homo sapiens_hsa041450.44538869
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.44456987
145Vibrio cholerae infection_Homo sapiens_hsa051100.43482527
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.43059262
147Viral carcinogenesis_Homo sapiens_hsa052030.42862343
148Insulin signaling pathway_Homo sapiens_hsa049100.42797590
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42760164
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41812007
151Small cell lung cancer_Homo sapiens_hsa052220.41613504
152Pancreatic cancer_Homo sapiens_hsa052120.41390342
153Ovarian steroidogenesis_Homo sapiens_hsa049130.41161056
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41128175
155Thyroid hormone synthesis_Homo sapiens_hsa049180.41034438
156Hedgehog signaling pathway_Homo sapiens_hsa043400.40977081
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.40806622
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40683961
159Salmonella infection_Homo sapiens_hsa051320.40646548
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40494541
161Arginine and proline metabolism_Homo sapiens_hsa003300.39776191
162Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37747069
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36722218
164Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34200082
165Malaria_Homo sapiens_hsa051440.32903850
166Leishmaniasis_Homo sapiens_hsa051400.32542163
167Steroid biosynthesis_Homo sapiens_hsa001000.32365395
168RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32319264
169Regulation of autophagy_Homo sapiens_hsa041400.30240926
170Vitamin digestion and absorption_Homo sapiens_hsa049770.26112614
171Renin-angiotensin system_Homo sapiens_hsa046140.23775462
172Maturity onset diabetes of the young_Homo sapiens_hsa049500.23018614
173Fatty acid elongation_Homo sapiens_hsa000620.22774858
174Alzheimers disease_Homo sapiens_hsa050100.22309910
175Sulfur metabolism_Homo sapiens_hsa009200.20081387
176Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19483789
177Asthma_Homo sapiens_hsa053100.19149673
178Viral myocarditis_Homo sapiens_hsa054160.18961369
179Linoleic acid metabolism_Homo sapiens_hsa005910.18482221
180Leukocyte transendothelial migration_Homo sapiens_hsa046700.18401899

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