SCAND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.48290684
2translational termination (GO:0006415)7.08163807
3ribosomal small subunit assembly (GO:0000028)6.63761792
4translational elongation (GO:0006414)6.15418859
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.12664475
6ribosomal small subunit biogenesis (GO:0042274)6.01650732
7protein targeting to ER (GO:0045047)5.99404734
8cotranslational protein targeting to membrane (GO:0006613)5.93595195
9DNA deamination (GO:0045006)5.77110432
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.68064132
11protein localization to endoplasmic reticulum (GO:0070972)5.63744422
12viral life cycle (GO:0019058)5.57678790
13cellular protein complex disassembly (GO:0043624)5.44798219
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.29015605
15translational initiation (GO:0006413)5.06126740
16protein complex disassembly (GO:0043241)4.89134150
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.81731465
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.81731465
19macromolecular complex disassembly (GO:0032984)4.53584652
20maturation of SSU-rRNA (GO:0030490)4.50996621
21antigen processing and presentation of endogenous antigen (GO:0019883)4.32449222
22purine deoxyribonucleotide catabolic process (GO:0009155)4.22615361
23protein targeting to membrane (GO:0006612)4.07060614
24ribosomal large subunit biogenesis (GO:0042273)3.97313387
25deoxyribose phosphate catabolic process (GO:0046386)3.85972472
26base-excision repair, AP site formation (GO:0006285)3.80391907
27protein maturation by protein folding (GO:0022417)3.72422528
28translation (GO:0006412)3.63861972
29antigen processing and presentation via MHC class Ib (GO:0002475)3.63395763
30ncRNA 3-end processing (GO:0043628)3.62331327
31negative regulation of erythrocyte differentiation (GO:0045647)3.57126152
32negative regulation of B cell apoptotic process (GO:0002903)3.55896870
33nuclear-transcribed mRNA catabolic process (GO:0000956)3.52854531
34pentose-phosphate shunt (GO:0006098)3.52384935
35pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.49517269
36heme biosynthetic process (GO:0006783)3.47967987
37chaperone-mediated protein transport (GO:0072321)3.37216847
38mRNA catabolic process (GO:0006402)3.35707241
39nucleotide salvage (GO:0043173)3.35164178
402-deoxyribonucleotide metabolic process (GO:0009394)3.29452501
41mitochondrial calcium ion transport (GO:0006851)3.25601741
42immunoglobulin mediated immune response (GO:0016064)3.25070340
43positive regulation of prostaglandin secretion (GO:0032308)3.23491386
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22776289
45protein complex biogenesis (GO:0070271)3.21379669
46UV protection (GO:0009650)3.20167173
47RNA catabolic process (GO:0006401)3.20071142
48purine nucleotide salvage (GO:0032261)3.18197925
49maternal placenta development (GO:0001893)3.17192012
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14155130
51purine deoxyribonucleotide metabolic process (GO:0009151)3.13149878
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.11619180
53negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.09324101
54GTP biosynthetic process (GO:0006183)3.08462742
55guanosine-containing compound biosynthetic process (GO:1901070)3.06524396
56deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.05259473
57protein retention in ER lumen (GO:0006621)3.03896125
58regulation of mitochondrial translation (GO:0070129)3.03204433
59NADPH regeneration (GO:0006740)3.02737322
60deoxyribose phosphate metabolic process (GO:0019692)3.00806400
61negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95699652
62heme metabolic process (GO:0042168)2.92034611
63establishment of protein localization to mitochondrial membrane (GO:0090151)2.89674653
64granulocyte differentiation (GO:0030851)2.88383913
65deoxyribose phosphate biosynthetic process (GO:0046385)2.87383119
662-deoxyribonucleotide biosynthetic process (GO:0009265)2.87383119
67T cell apoptotic process (GO:0070231)2.87125920
68autophagic vacuole fusion (GO:0000046)2.86746474
69respiratory electron transport chain (GO:0022904)2.86031547
70regulation of gamma-delta T cell differentiation (GO:0045586)2.86029562
71negative regulation of myeloid cell apoptotic process (GO:0033033)2.85027230
72mitochondrial respiratory chain complex assembly (GO:0033108)2.83199504
73regulation of release of cytochrome c from mitochondria (GO:0090199)2.81094705
74electron transport chain (GO:0022900)2.80343103
75galactose catabolic process (GO:0019388)2.79828489
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76715828
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.76715828
78NADH dehydrogenase complex assembly (GO:0010257)2.76715828
79porphyrin-containing compound biosynthetic process (GO:0006779)2.76626089
80ribonucleoprotein complex biogenesis (GO:0022613)2.76476608
81establishment of protein localization to membrane (GO:0090150)2.75061735
82cytochrome complex assembly (GO:0017004)2.74707803
83protein targeting to mitochondrion (GO:0006626)2.74349720
84CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73102111
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72752077
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72641601
87response to interferon-beta (GO:0035456)2.72506820
88platelet formation (GO:0030220)2.72281724
89chaperone mediated protein folding requiring cofactor (GO:0051085)2.72135758
90oxidative phosphorylation (GO:0006119)2.71906096
91UTP biosynthetic process (GO:0006228)2.70588914
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69757684
93actin nucleation (GO:0045010)2.68061288
94peptidyl-arginine omega-N-methylation (GO:0035247)2.66707047
95positive regulation of B cell differentiation (GO:0045579)2.66616048
96positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.66224726
97viral protein processing (GO:0019082)2.66107918
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66000540
99ATP synthesis coupled proton transport (GO:0015986)2.66000540
100establishment of protein localization to mitochondrion (GO:0072655)2.65474357
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64543258
102lipoxygenase pathway (GO:0019372)2.62241767
103phosphatidylglycerol biosynthetic process (GO:0006655)2.61265893
104regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59930833
105GDP-mannose metabolic process (GO:0019673)2.59248343
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.58848235
107Peyers patch development (GO:0048541)2.58530845
108mucosal-associated lymphoid tissue development (GO:0048537)2.58530845
109purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.58197024
110CTP biosynthetic process (GO:0006241)2.57952809
111CTP metabolic process (GO:0046036)2.57952809
112regulation of mitochondrial membrane potential (GO:0051881)2.57935983
113deoxyribonucleotide metabolic process (GO:0009262)2.57619287
114pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.56554592
115lymphocyte apoptotic process (GO:0070227)2.56347692
116regulation of erythrocyte differentiation (GO:0045646)2.55095052
117protein targeting (GO:0006605)2.54689271
118negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.54139288
119prostanoid biosynthetic process (GO:0046457)2.54043094
120prostaglandin biosynthetic process (GO:0001516)2.54043094
121mature B cell differentiation involved in immune response (GO:0002313)2.53338037
122pyrimidine nucleoside salvage (GO:0043097)2.52489263
123pyrimidine-containing compound salvage (GO:0008655)2.52489263
124regulation of gamma-delta T cell activation (GO:0046643)2.51869801
125pentose metabolic process (GO:0019321)2.51730418
126positive regulation of gamma-delta T cell activation (GO:0046645)2.51367827
127mannosylation (GO:0097502)2.51360486
128regulation of B cell apoptotic process (GO:0002902)2.50346506
129regulation of protein heterodimerization activity (GO:0043497)2.49838890
130metallo-sulfur cluster assembly (GO:0031163)2.48866703
131iron-sulfur cluster assembly (GO:0016226)2.48866703
132negative regulation of innate immune response (GO:0045824)2.48588673
133regulation of cellular amino acid metabolic process (GO:0006521)2.47475683
134antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.47383741
135UTP metabolic process (GO:0046051)2.45645425
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45611861
137RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45611861
138nucleoside salvage (GO:0043174)2.45320587
139response to laminar fluid shear stress (GO:0034616)2.45268248
140pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.44110882
141negative regulation of DNA-templated transcription, elongation (GO:0032785)2.43607821
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42304269
143tetrapyrrole biosynthetic process (GO:0033014)2.41172188
144positive thymic T cell selection (GO:0045059)2.40915246
145regulation of prostaglandin secretion (GO:0032306)2.39970436
146negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.39556445
147aerobic respiration (GO:0009060)2.39480000
148activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.38767125
149positive regulation of antigen processing and presentation (GO:0002579)2.38573404
150regulation of respiratory burst (GO:0060263)2.38441957
151NIK/NF-kappaB signaling (GO:0038061)2.38426836
152positive regulation of extracellular matrix organization (GO:1903055)2.37068639
153protein insertion into membrane (GO:0051205)2.37064471
154glucose catabolic process (GO:0006007)2.36876622
155positive regulation of TOR signaling (GO:0032008)2.36720283
156virion assembly (GO:0019068)2.36411659
157pyrimidine nucleotide catabolic process (GO:0006244)2.36066463
158establishment of protein localization to organelle (GO:0072594)2.34295758
159porphyrin-containing compound metabolic process (GO:0006778)2.34063617
160regulation of type I interferon-mediated signaling pathway (GO:0060338)2.33743632
161positive regulation of histone deacetylation (GO:0031065)2.33386724
162barbed-end actin filament capping (GO:0051016)2.32002276
163regulation of interleukin-12 biosynthetic process (GO:0045075)2.29090060
164cellular response to interferon-beta (GO:0035458)2.28945068
165regulation of metalloenzyme activity (GO:0048552)2.28818342
166positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27602216
167positive regulation of protein deacetylation (GO:0090312)2.25730121
168negative regulation of necroptotic process (GO:0060546)2.25526783
169sequestering of actin monomers (GO:0042989)2.25404368
170regulation of superoxide anion generation (GO:0032928)2.23995093
171regulation of necroptotic process (GO:0060544)2.22028933
172cellular component biogenesis (GO:0044085)2.21329643
173deoxyribonucleotide catabolic process (GO:0009264)2.20243844
174negative regulation of phagocytosis (GO:0050765)2.20083237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74562902
2VDR_21846776_ChIP-Seq_THP-1_Human2.79531251
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.61634471
4MYC_22102868_ChIP-Seq_BL_Human2.55659865
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43618558
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38780121
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.31853704
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18694136
9TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14292521
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.10878033
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93752577
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93099345
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92363278
14E2F7_22180533_ChIP-Seq_HELA_Human1.91941818
15CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87912568
16MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86999585
17XRN2_22483619_ChIP-Seq_HELA_Human1.86076187
18LXR_22292898_ChIP-Seq_THP-1_Human1.85549549
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82513346
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79274304
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.76561750
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76360929
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76080202
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74980063
25SCL_19346495_ChIP-Seq_HPC-7_Human1.73382919
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71210475
27* VDR_24763502_ChIP-Seq_THP-1_Human1.69760285
28* ETS1_20019798_ChIP-Seq_JURKAT_Human1.69428121
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.69199708
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65025110
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64653553
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64332397
33MAF_26560356_Chip-Seq_TH1_Human1.61477935
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59547438
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58699806
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58009081
37TCF7_22412390_ChIP-Seq_EML_Mouse1.56966272
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.56857739
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56677304
40UTX_26944678_Chip-Seq_JUKART_Human1.53658029
41* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51585917
42MAF_26560356_Chip-Seq_TH2_Human1.47454710
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47364147
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.44862423
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.44775404
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42873692
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42798494
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42006558
49BCL6_27268052_Chip-Seq_Bcells_Human1.41635769
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.37676351
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37619516
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37255198
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.34761737
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34599342
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33461794
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33123059
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.33045721
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32239780
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31546083
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31405694
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30683849
62* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30357220
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30235615
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29550692
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29061791
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28607721
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27868631
68* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27615557
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27552197
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27281549
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.27236576
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27005729
73PHF8_20622854_ChIP-Seq_HELA_Human1.26757777
74SPI1_23547873_ChIP-Seq_NB4_Human1.25893371
75BCOR_27268052_Chip-Seq_Bcells_Human1.24959268
76KDM2B_26808549_Chip-Seq_DND41_Human1.24094923
77E2F1_20622854_ChIP-Seq_HELA_Human1.23919624
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.23827254
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23801066
80RACK7_27058665_Chip-Seq_MCF-7_Human1.22652653
81P68_20966046_ChIP-Seq_HELA_Human1.22531909
82DCP1A_22483619_ChIP-Seq_HELA_Human1.22357721
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22303605
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22199619
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.21616176
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21171329
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.21098616
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20970860
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20646102
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.20241668
91CTCF_26484167_Chip-Seq_Bcells_Mouse1.19136382
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18681212
93* GABP_19822575_ChIP-Seq_HepG2_Human1.18192419
94* VDR_23849224_ChIP-Seq_CD4+_Human1.17969672
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17654249
96CIITA_25753668_ChIP-Seq_RAJI_Human1.17492619
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17137961
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16621578
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16604347
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16543901
101ZNF263_19887448_ChIP-Seq_K562_Human1.16214698
102CTCF_21964334_Chip-Seq_Bcells_Human1.15450323
103* CTCF_20526341_ChIP-Seq_ESCs_Human1.15327855
104CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15191446
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14653443
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14085895
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13941503
108IRF8_21731497_ChIP-ChIP_J774_Mouse1.13493734
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13493490
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11296817
111* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11208074
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10916994
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.10800997
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10614936
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10238148
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09034416
117ATF3_27146783_Chip-Seq_COLON_Human1.08805966
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08781529
119RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08775730
120CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08464018
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08145671
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08116602
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06658412
124YY1_21170310_ChIP-Seq_MESCs_Mouse1.06100103
125P300_27268052_Chip-Seq_Bcells_Human1.06047074
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05829485
127FOXP3_21729870_ChIP-Seq_TREG_Human1.05049389
128TTF2_22483619_ChIP-Seq_HELA_Human1.04186001
129* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03843795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system2.72596415
2MP0003303_peritoneal_inflammation2.67251123
3MP0009840_abnormal_foam_cell2.62802366
4MP0003300_gastrointestinal_ulcer2.59160797
5MP0001835_abnormal_antigen_presentation2.49725193
6MP0003878_abnormal_ear_physiology2.41518220
7MP0005377_hearing/vestibular/ear_phenot2.41518220
8MP0003283_abnormal_digestive_organ2.33779730
9MP0003436_decreased_susceptibility_to2.27449229
10MP0000490_abnormal_crypts_of2.25450862
11MP0005397_hematopoietic_system_phenotyp2.13543196
12MP0001545_abnormal_hematopoietic_system2.13543196
13MP0010155_abnormal_intestine_physiology2.11796744
14MP0009333_abnormal_splenocyte_physiolog2.10950569
15MP0009785_altered_susceptibility_to2.08891096
16MP0001873_stomach_inflammation2.08128323
17MP0003693_abnormal_embryo_hatching2.06096235
18MP0003866_abnormal_defecation2.04080352
19MP0002822_catalepsy1.98608486
20MP0005025_abnormal_response_to1.88698691
21MP0005451_abnormal_body_composition1.86160966
22MP0009278_abnormal_bone_marrow1.81406889
23MP0003075_altered_response_to1.79372680
24MP0003656_abnormal_erythrocyte_physiolo1.77422885
25MP0005671_abnormal_response_to1.76024244
26MP0005387_immune_system_phenotype1.70409565
27MP0001790_abnormal_immune_system1.70409565
28MP0003763_abnormal_thymus_physiology1.70267196
29MP0002398_abnormal_bone_marrow1.69181041
30MP0003172_abnormal_lysosome_physiology1.69047047
31MP0002166_altered_tumor_susceptibility1.68385639
32MP0001800_abnormal_humoral_immune1.67955819
33MP0003191_abnormal_cellular_cholesterol1.66953510
34MP0005645_abnormal_hypothalamus_physiol1.66182266
35MP0009764_decreased_sensitivity_to1.65940970
36MP0005000_abnormal_immune_tolerance1.64668453
37MP0005360_urolithiasis1.63938625
38MP0002132_abnormal_respiratory_system1.63577855
39MP0002452_abnormal_antigen_presenting1.62008581
40MP0002723_abnormal_immune_serum1.60765014
41MP0001819_abnormal_immune_cell1.59997806
42MP0002420_abnormal_adaptive_immunity1.58683058
43MP0002396_abnormal_hematopoietic_system1.57740035
44MP0005083_abnormal_biliary_tract1.56896502
45MP0001663_abnormal_digestive_system1.53489417
46MP0002722_abnormal_immune_system1.47901066
47MP0000716_abnormal_immune_system1.47749036
48MP0004858_abnormal_nervous_system1.47117170
49MP0008260_abnormal_autophagy1.46310720
50MP0005464_abnormal_platelet_physiology1.45644410
51MP0010352_gastrointestinal_tract_polyps1.45445621
52MP0002429_abnormal_blood_cell1.43891197
53MP0002138_abnormal_hepatobiliary_system1.42594472
54MP0002405_respiratory_system_inflammati1.42132059
55MP0000465_gastrointestinal_hemorrhage1.41775969
56MP0000689_abnormal_spleen_morphology1.40946690
57MP0003186_abnormal_redox_activity1.40588822
58MP0005058_abnormal_lysosome_morphology1.38330494
59MP0004957_abnormal_blastocyst_morpholog1.37541731
60MP0001845_abnormal_inflammatory_respons1.36054134
61MP0000681_abnormal_thyroid_gland1.36031909
62MP0005670_abnormal_white_adipose1.34952126
63MP0009643_abnormal_urine_homeostasis1.33947137
64MP0003705_abnormal_hypodermis_morpholog1.33147417
65MP0004947_skin_inflammation1.32205392
66MP0001905_abnormal_dopamine_level1.31454390
67MP0002148_abnormal_hypersensitivity_rea1.31369394
68MP0001764_abnormal_homeostasis1.30787237
69MP0005636_abnormal_mineral_homeostasis1.30290201
70MP0002419_abnormal_innate_immunity1.30156259
71MP0005381_digestive/alimentary_phenotyp1.28804026
72MP0000477_abnormal_intestine_morphology1.28666003
73MP0006082_CNS_inflammation1.28560728
74MP0000858_altered_metastatic_potential1.28503257
75MP0008469_abnormal_protein_level1.26841045
76MP0003806_abnormal_nucleotide_metabolis1.23530377
77MP0004808_abnormal_hematopoietic_stem1.20937957
78MP0000604_amyloidosis1.20348372
79MP0000703_abnormal_thymus_morphology1.19984272
80MP0003786_premature_aging1.18772329
81MP0003724_increased_susceptibility_to1.18285914
82MP0004510_myositis1.17666763
83MP0009379_abnormal_foot_pigmentation1.13246750
84MP0002139_abnormal_hepatobiliary_system1.12750399
85MP0002006_tumorigenesis1.10828945
86MP0006036_abnormal_mitochondrial_physio1.06909551
87MP0001853_heart_inflammation1.05033293
88MP0001533_abnormal_skeleton_physiology1.04296983
89MP0005310_abnormal_salivary_gland1.03046682
90MP0001542_abnormal_bone_strength1.00969485
91MP0005220_abnormal_exocrine_pancreas0.98786499
92MP0002019_abnormal_tumor_incidence0.98031151
93MP0005165_increased_susceptibility_to0.96028013
94MP0005584_abnormal_enzyme/coenzyme_acti0.95652076
95MP0001348_abnormal_lacrimal_gland0.93541916
96MP0000609_abnormal_liver_physiology0.92900764
97MP0000678_abnormal_parathyroid_gland0.91536415
98MP0005319_abnormal_enzyme/_coenzyme0.91364446
99MP0009763_increased_sensitivity_to0.90916396
100MP0001881_abnormal_mammary_gland0.89986332
101MP0005084_abnormal_gallbladder_morpholo0.89888161
102MP0000598_abnormal_liver_morphology0.89229296
103MP0000343_altered_response_to0.89160068
104MP0005166_decreased_susceptibility_to0.88910422
105MP0006035_abnormal_mitochondrial_morpho0.87983977
106MP0000313_abnormal_cell_death0.87314673
107MP0002933_joint_inflammation0.86829453
108MP0003329_amyloid_beta_deposits0.86782760
109MP0003111_abnormal_nucleus_morphology0.86389662
110MP0003077_abnormal_cell_cycle0.86237529
111MP0002653_abnormal_ependyma_morphology0.83655586
112MP0008875_abnormal_xenobiotic_pharmacok0.83620972
113MP0002136_abnormal_kidney_physiology0.82892450
114MP0008995_early_reproductive_senescence0.82597665
115MP0000750_abnormal_muscle_regeneration0.80383276
116MP0000015_abnormal_ear_pigmentation0.78607475
117MP0005023_abnormal_wound_healing0.77101031
118MP0005390_skeleton_phenotype0.75248104
119MP0003011_delayed_dark_adaptation0.74705755
120MP0002089_abnormal_postnatal_growth/wei0.73743195
121MP0005075_abnormal_melanosome_morpholog0.70682670
122MP0008873_increased_physiological_sensi0.70389932
123MP0000358_abnormal_cell_content/0.69901217
124MP0008874_decreased_physiological_sensi0.69791664
125MP0005076_abnormal_cell_differentiation0.68867543
126MP0001666_abnormal_nutrient_absorption0.68590468
127MP0003453_abnormal_keratinocyte_physiol0.68450403
128MP0005365_abnormal_bile_salt0.68392678
129MP0008961_abnormal_basal_metabolism0.68187173
130MP0006054_spinal_hemorrhage0.67433313
131MP0009765_abnormal_xenobiotic_induced0.63779159
132MP0004147_increased_porphyrin_level0.62746676
133MP0005330_cardiomyopathy0.62713816
134MP0004782_abnormal_surfactant_physiolog0.62118202
135MP0001727_abnormal_embryo_implantation0.61144080

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.65831797
2Abnormal number of erythroid precursors (HP:0012131)5.39623558
3Reticulocytopenia (HP:0001896)4.69527155
4Petechiae (HP:0000967)4.23681209
5Pallor (HP:0000980)3.99049967
6Macrocytic anemia (HP:0001972)3.83593503
7Nasal polyposis (HP:0100582)3.51515241
8Abnormality of glycolipid metabolism (HP:0010969)3.46152455
9Abnormality of liposaccharide metabolism (HP:0010968)3.46152455
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.46152455
11Elevated erythrocyte sedimentation rate (HP:0003565)3.42946187
12Abnormality of the nasal mucosa (HP:0000433)3.36962538
13Thrombocytosis (HP:0001894)3.35177636
14Ragged-red muscle fibers (HP:0003200)3.13872217
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.11050335
16Increased CSF lactate (HP:0002490)3.10666806
17Chronic otitis media (HP:0000389)3.08234602
18Pustule (HP:0200039)3.03887531
19Obstructive lung disease (HP:0006536)3.02550522
20Chronic obstructive pulmonary disease (HP:0006510)3.02550522
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00463567
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00463567
23Gastrointestinal inflammation (HP:0004386)2.96575314
24Abnormality of reticulocytes (HP:0004312)2.96481549
25Prolonged neonatal jaundice (HP:0006579)2.89747161
26Inflammation of the large intestine (HP:0002037)2.79589989
27Renal Fanconi syndrome (HP:0001994)2.78199764
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77160807
29Increased cerebral lipofuscin (HP:0011813)2.76002296
30Hypertensive crisis (HP:0100735)2.74358326
31Polycythemia (HP:0001901)2.72777802
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.72593180
33Increased serum ferritin (HP:0003281)2.71534902
34Mediastinal lymphadenopathy (HP:0100721)2.69558289
35Increased IgM level (HP:0003496)2.68803027
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.66818475
37IgM deficiency (HP:0002850)2.66266998
38Microretrognathia (HP:0000308)2.64058602
39Colitis (HP:0002583)2.61792995
40Increased muscle lipid content (HP:0009058)2.57818388
41Abnormal platelet function (HP:0011869)2.57472869
42Impaired platelet aggregation (HP:0003540)2.57472869
43Cerebral palsy (HP:0100021)2.55626945
44Progressive macrocephaly (HP:0004481)2.54347678
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53570642
46Abnormality of T cell physiology (HP:0011840)2.51793357
47Hepatosplenomegaly (HP:0001433)2.47501627
48Exercise intolerance (HP:0003546)2.47484987
49Increased intramyocellular lipid droplets (HP:0012240)2.46970742
50Multiple enchondromatosis (HP:0005701)2.46854879
51Cerebral edema (HP:0002181)2.46092244
52Microvesicular hepatic steatosis (HP:0001414)2.46062439
53Panhypogammaglobulinemia (HP:0003139)2.39817250
543-Methylglutaconic aciduria (HP:0003535)2.37923905
55Systemic lupus erythematosus (HP:0002725)2.36936577
56Chronic mucocutaneous candidiasis (HP:0002728)2.36124284
57Recurrent cutaneous fungal infections (HP:0011370)2.36124284
58Recurrent bronchitis (HP:0002837)2.35146816
59Increased serum lactate (HP:0002151)2.34796191
60Progressive neurologic deterioration (HP:0002344)2.34567076
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33659080
62Respiratory failure (HP:0002878)2.30647532
63Progressive microcephaly (HP:0000253)2.30396486
64Opisthotonus (HP:0002179)2.30150740
65Type I transferrin isoform profile (HP:0003642)2.29719274
66Recurrent fungal infections (HP:0002841)2.29577010
67Emotional lability (HP:0000712)2.26412103
68Hepatic necrosis (HP:0002605)2.25869402
69Vacuolated lymphocytes (HP:0001922)2.24961713
70Prolonged bleeding time (HP:0003010)2.24908011
71Rhabdomyolysis (HP:0003201)2.21940775
72Urinary glycosaminoglycan excretion (HP:0003541)2.19892937
73Mucopolysacchariduria (HP:0008155)2.19892937
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17449945
75Dicarboxylic aciduria (HP:0003215)2.17449945
76Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16958556
77Exertional dyspnea (HP:0002875)2.15159915
78Growth hormone excess (HP:0000845)2.13626431
79Hepatocellular necrosis (HP:0001404)2.12175454
80Vertebral compression fractures (HP:0002953)2.10197644
81Recurrent viral infections (HP:0004429)2.10180353
82Eczematoid dermatitis (HP:0000976)2.09720409
83Large eyes (HP:0001090)2.09356579
84Rough bone trabeculation (HP:0100670)2.09235667
85Abnormality of iron homeostasis (HP:0011031)2.08875547
86Acanthocytosis (HP:0001927)2.05976288
87Trismus (HP:0000211)2.04431042
88Abnormal protein glycosylation (HP:0012346)2.02702320
89Abnormal glycosylation (HP:0012345)2.02702320
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02702320
91Abnormal protein N-linked glycosylation (HP:0012347)2.02702320
92Recurrent abscess formation (HP:0002722)2.00627033
93Urticaria (HP:0001025)2.00537833
94Mitochondrial inheritance (HP:0001427)2.00440862
95Dysostosis multiplex (HP:0000943)1.99462132
96Reticulocytosis (HP:0001923)1.99143395
97Epistaxis (HP:0000421)1.98694610
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98537916
99Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98537916
100Abnormality of polysaccharide metabolism (HP:0011012)1.98537916
101Poikiloderma (HP:0001029)1.97512842
102Granulocytopenia (HP:0001913)1.94396167
103Aplastic anemia (HP:0001915)1.94312171
104Abnormal mitochondria in muscle tissue (HP:0008316)1.93747258
105Cellulitis (HP:0100658)1.93488829
106Abnormality of T cells (HP:0002843)1.92952799
107Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91754530
108Abnormality of transition element cation homeostasis (HP:0011030)1.90552164
109Muscle fiber atrophy (HP:0100295)1.90275365
110Recurrent skin infections (HP:0001581)1.89949144
111Abnormal hemoglobin (HP:0011902)1.89705864
112Increased serum pyruvate (HP:0003542)1.88094874
113Pancytopenia (HP:0001876)1.87641939
114Amyloidosis (HP:0011034)1.86927773
115Protrusio acetabuli (HP:0003179)1.86590747
116Microcytic anemia (HP:0001935)1.85310372
117Interstitial pulmonary disease (HP:0006530)1.84650282
118Loss of speech (HP:0002371)1.84526027
119Hypergammaglobulinemia (HP:0010702)1.84487631
120Poikilocytosis (HP:0004447)1.83164580
121Abnormality of B cell number (HP:0010975)1.82888002
122Myopathic facies (HP:0002058)1.81870243
123Villous atrophy (HP:0011473)1.80695447
124Abnormality of small intestinal villus morphology (HP:0011472)1.80695447
125Abnormality of macrophages (HP:0004311)1.80284126
126Lipid accumulation in hepatocytes (HP:0006561)1.78982877
127Failure to thrive in infancy (HP:0001531)1.78357515
128Acute necrotizing encephalopathy (HP:0006965)1.78290890
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78264066
130Abnormal cartilage morphology (HP:0002763)1.77966220
131Reduced antithrombin III activity (HP:0001976)1.77352255
132Myositis (HP:0100614)1.76331705
133Papilloma (HP:0012740)1.76250252
134Verrucae (HP:0200043)1.76250252
135Progressive muscle weakness (HP:0003323)1.75811108
136Recurrent bacterial skin infections (HP:0005406)1.75482570
137Acute encephalopathy (HP:0006846)1.74110038
138Agammaglobulinemia (HP:0004432)1.73761573
139Hyperphosphaturia (HP:0003109)1.72870567
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72075146
141Stomatitis (HP:0010280)1.71809975
142Abnormality of fatty-acid metabolism (HP:0004359)1.71641743
143Late onset (HP:0003584)1.71332440
144Purpura (HP:0000979)1.70657538
145Cholecystitis (HP:0001082)1.70416341
146Abnormal gallbladder physiology (HP:0012438)1.70416341
147Increased density of long bones (HP:0006392)1.69632763
148Generalized aminoaciduria (HP:0002909)1.69189950
149Meningitis (HP:0001287)1.68776490
150Flat acetabular roof (HP:0003180)1.67203710
151Lactic acidosis (HP:0003128)1.63401862
152Cheilitis (HP:0100825)1.61714454
153Increased hepatocellular lipid droplets (HP:0006565)1.61199959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.89546282
2ERN13.84878321
3NME23.70155196
4MAP3K103.39037790
5MAP4K13.20153058
6TRIB32.84892011
7TLK12.78454289
8EEF2K2.75090666
9TESK22.40520507
10BCKDK2.17095621
11TBK12.15122190
12PIM22.14489627
13PKN22.08616484
14BUB12.00099870
15MAP2K21.90391127
16KDR1.88671845
17MAP3K111.88351518
18LRRK21.87408571
19LIMK11.84089583
20DYRK31.74523172
21TESK11.73752548
22BLK1.66548507
23CDK191.64751544
24TXK1.59657222
25TAOK21.55023197
26GRK61.50696684
27ILK1.48155390
28SCYL21.46465633
29ZAP701.45925288
30MST1R1.41859977
31TYK21.41401535
32SMG11.39419413
33DAPK31.36695955
34KIT1.34341829
35IKBKE1.28713274
36BTK1.27757758
37TEC1.27070406
38RPS6KA41.26833147
39MAP3K71.26090679
40MAP4K21.23291429
41NEK21.22983183
42DAPK11.22834717
43PAK41.22729316
44VRK11.20613356
45TAOK11.19690524
46FLT31.11852534
47DYRK1B1.09175443
48FGFR41.06997775
49RPS6KB21.05645911
50STK161.02646864
51SIK11.01468480
52TAOK31.01278027
53MAP2K70.96047332
54IKBKB0.92793174
55CSNK1G30.91422624
56TNK20.90145146
57MAP3K80.89063892
58CSF1R0.84468592
59JAK30.78619748
60MAPKAPK30.78529522
61SYK0.78415700
62PIK3CA0.77526332
63BRAF0.75692390
64PIM10.75018007
65IRAK40.74747023
66ICK0.74570144
67STK100.73724496
68IRAK30.73695668
69MAPK110.73675545
70CDK40.72970358
71EPHB20.72350111
72PTK60.68816455
73FES0.67572306
74PRKG20.67462553
75CSK0.66581628
76RAF10.65216922
77ZAK0.64985077
78ABL20.64761714
79PASK0.64426296
80DYRK20.62463923
81BMX0.61272383
82ARAF0.59934036
83PAK10.58192709
84CSNK1A1L0.57366954
85EIF2AK10.56427091
86GRK50.54954858
87PRPF4B0.53749132
88MAP3K10.53670112
89LYN0.53326090
90PRKD20.53275142
91TGFBR20.52431537
92MAP3K30.50869283
93MAP2K30.49495345
94GRK70.49487929
95MATK0.49063729
96EPHB10.48487833
97CHUK0.47331082
98MAPK40.47150117
99EPHA20.46328175
100RPS6KA10.46087474
101MUSK0.45189232
102CSNK1G20.44818550
103RPS6KA20.44747188
104HCK0.44653393
105JAK20.42487091
106MAP3K50.42048893
107AURKB0.41813875
108DMPK0.41172650
109PRKD30.40582934
110WEE10.40487005
111LCK0.40073201
112PAK20.38435972
113CAMK2G0.38032428
114MYLK0.37661375
115PRKCI0.37013005
116CSNK1G10.36624609
117TGFBR10.36469869
118RPS6KA60.35456971
119MST40.35306234
120CAMKK20.33837685
121CDK70.32950330
122SIK30.32949294
123HIPK20.32109729
124CCNB10.31966906
125MAP3K120.31360003
126MAPKAPK50.31168076
127PRKD10.30594109
128RPS6KC10.29831513
129RPS6KL10.29831513
130AKT20.29798973
131TIE10.29793801
132MAPKAPK20.29469273
133ITK0.29383210
134AURKA0.29239782
135PRKCD0.29184587
136RPS6KA50.29180021
137CDK140.28139939
138CSNK2A10.28029906
139SIK20.27960486

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.88701960
2Sulfur relay system_Homo sapiens_hsa041224.32065342
3DNA replication_Homo sapiens_hsa030302.33611628
4Sulfur metabolism_Homo sapiens_hsa009202.26511763
5Parkinsons disease_Homo sapiens_hsa050122.03865312
6Oxidative phosphorylation_Homo sapiens_hsa001902.03534018
7Fatty acid elongation_Homo sapiens_hsa000621.98264480
8Allograft rejection_Homo sapiens_hsa053301.95907724
9Asthma_Homo sapiens_hsa053101.92541223
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90006581
11Pentose phosphate pathway_Homo sapiens_hsa000301.86662658
12Folate biosynthesis_Homo sapiens_hsa007901.84656408
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81276689
14Primary immunodeficiency_Homo sapiens_hsa053401.79597522
15Autoimmune thyroid disease_Homo sapiens_hsa053201.76019213
16Graft-versus-host disease_Homo sapiens_hsa053321.75297762
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68620495
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.68007282
19Rheumatoid arthritis_Homo sapiens_hsa053231.58415016
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56292744
21Base excision repair_Homo sapiens_hsa034101.56009184
22Pyrimidine metabolism_Homo sapiens_hsa002401.54291009
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.51330272
24Proteasome_Homo sapiens_hsa030501.47242829
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.43219166
26Antigen processing and presentation_Homo sapiens_hsa046121.41364887
27Type I diabetes mellitus_Homo sapiens_hsa049401.41299638
28Leishmaniasis_Homo sapiens_hsa051401.36437449
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36437433
30Other glycan degradation_Homo sapiens_hsa005111.34469562
31Systemic lupus erythematosus_Homo sapiens_hsa053221.31538305
32Bladder cancer_Homo sapiens_hsa052191.29137659
33Spliceosome_Homo sapiens_hsa030401.26211470
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25752760
35Alzheimers disease_Homo sapiens_hsa050101.25365714
36Huntingtons disease_Homo sapiens_hsa050161.24857137
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.22266852
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21296363
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17989626
40Mismatch repair_Homo sapiens_hsa034301.17324027
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14826105
42Acute myeloid leukemia_Homo sapiens_hsa052211.08616042
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.06209684
44Fat digestion and absorption_Homo sapiens_hsa049751.05284608
45Staphylococcus aureus infection_Homo sapiens_hsa051501.04533259
46Collecting duct acid secretion_Homo sapiens_hsa049661.04298783
47Peroxisome_Homo sapiens_hsa041461.02968762
48Phenylalanine metabolism_Homo sapiens_hsa003601.02861559
49Carbon metabolism_Homo sapiens_hsa012001.02671607
50Viral myocarditis_Homo sapiens_hsa054161.01518788
51Vibrio cholerae infection_Homo sapiens_hsa051100.99528493
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98785599
53Galactose metabolism_Homo sapiens_hsa000520.98213800
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97325853
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.96555566
56RNA polymerase_Homo sapiens_hsa030200.95388895
57B cell receptor signaling pathway_Homo sapiens_hsa046620.95189582
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92387705
59N-Glycan biosynthesis_Homo sapiens_hsa005100.89362070
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88284979
61Selenocompound metabolism_Homo sapiens_hsa004500.86801009
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85795061
63Homologous recombination_Homo sapiens_hsa034400.84375737
64Caffeine metabolism_Homo sapiens_hsa002320.83568298
65Shigellosis_Homo sapiens_hsa051310.83382112
66Fructose and mannose metabolism_Homo sapiens_hsa000510.83152728
67Apoptosis_Homo sapiens_hsa042100.82192593
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80911549
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80329951
70Chronic myeloid leukemia_Homo sapiens_hsa052200.79584803
71Protein export_Homo sapiens_hsa030600.78723225
72Tyrosine metabolism_Homo sapiens_hsa003500.76713276
73Fatty acid degradation_Homo sapiens_hsa000710.75070912
74One carbon pool by folate_Homo sapiens_hsa006700.74907103
75Osteoclast differentiation_Homo sapiens_hsa043800.73989686
76Legionellosis_Homo sapiens_hsa051340.73187763
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72924381
78Purine metabolism_Homo sapiens_hsa002300.72768680
79Measles_Homo sapiens_hsa051620.72565350
80Glutathione metabolism_Homo sapiens_hsa004800.72277463
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.71450790
82Herpes simplex infection_Homo sapiens_hsa051680.70490337
83Epstein-Barr virus infection_Homo sapiens_hsa051690.70152293
84p53 signaling pathway_Homo sapiens_hsa041150.69442753
85Phagosome_Homo sapiens_hsa041450.69069534
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68412977
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67081393
88Synaptic vesicle cycle_Homo sapiens_hsa047210.66031569
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65070313
90Pyruvate metabolism_Homo sapiens_hsa006200.64278851
91Notch signaling pathway_Homo sapiens_hsa043300.63886147
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.61629099
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60385183
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59356388
95Linoleic acid metabolism_Homo sapiens_hsa005910.59151246
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58755529
97Hematopoietic cell lineage_Homo sapiens_hsa046400.58633590
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58462564
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58424242
100Nucleotide excision repair_Homo sapiens_hsa034200.58229762
101Arachidonic acid metabolism_Homo sapiens_hsa005900.58225278
102Biosynthesis of amino acids_Homo sapiens_hsa012300.55971979
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55715156
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55332963
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55236810
106Regulation of autophagy_Homo sapiens_hsa041400.55059682
107Hepatitis B_Homo sapiens_hsa051610.53651549
108Thyroid cancer_Homo sapiens_hsa052160.52706589
109Toxoplasmosis_Homo sapiens_hsa051450.51137568
110Tuberculosis_Homo sapiens_hsa051520.47829444
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46098354
112T cell receptor signaling pathway_Homo sapiens_hsa046600.45213505
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.44749717
114Malaria_Homo sapiens_hsa051440.44068967
115Viral carcinogenesis_Homo sapiens_hsa052030.43956870
116Metabolic pathways_Homo sapiens_hsa011000.43711151
117Fatty acid metabolism_Homo sapiens_hsa012120.43593365
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43579136
119Lysosome_Homo sapiens_hsa041420.43478081
120Cardiac muscle contraction_Homo sapiens_hsa042600.43465300
121Alcoholism_Homo sapiens_hsa050340.43180946
122Salmonella infection_Homo sapiens_hsa051320.43070099
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.42998677
124Pertussis_Homo sapiens_hsa051330.42964597
125Butanoate metabolism_Homo sapiens_hsa006500.42059689
126HTLV-I infection_Homo sapiens_hsa051660.40554239
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40004598
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.39369797
129Influenza A_Homo sapiens_hsa051640.38420664
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36299883
131Chemical carcinogenesis_Homo sapiens_hsa052040.36118318
132Vitamin B6 metabolism_Homo sapiens_hsa007500.29755194

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