ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.97235344
2	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.25132945
3	cellular response to ATP (GO:0071318)	4.07614876
4	L-fucose catabolic process (GO:0042355)	3.82596281
5	fucose catabolic process (GO:0019317)	3.82596281
6	L-fucose metabolic process (GO:0042354)	3.82596281
7	detection of light stimulus involved in sensory perception (GO:0050962)	3.77715502
8	detection of light stimulus involved in visual perception (GO:0050908)	3.77715502
9	sulfation (GO:0051923)	3.70554738
10	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.64675916
11	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.64675916
12	regulation of translation, ncRNA-mediated (GO:0045974)	3.64675916
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.46187801
14	regulation of skeletal muscle contraction (GO:0014819)	3.38578935
15	DNA deamination (GO:0045006)	3.33268226
16	indolalkylamine metabolic process (GO:0006586)	3.29932221
17	tryptophan catabolic process (GO:0006569)	3.22235421
18	indole-containing compound catabolic process (GO:0042436)	3.22235421
19	indolalkylamine catabolic process (GO:0046218)	3.22235421
20	cellular response to exogenous dsRNA (GO:0071360)	3.17097819
21	neuronal action potential (GO:0019228)	3.16769124
22	interkinetic nuclear migration (GO:0022027)	3.16514190
23	kynurenine metabolic process (GO:0070189)	3.16314540
24	gamma-aminobutyric acid transport (GO:0015812)	3.13469639
25	membrane depolarization during action potential (GO:0086010)	3.04505731
26	activated T cell proliferation (GO:0050798)	3.03669946
27	urinary tract smooth muscle contraction (GO:0014848)	3.01179036
28	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.01094115
29	regulation of hippo signaling (GO:0035330)	2.93059376
30	negative regulation of Rho protein signal transduction (GO:0035024)	2.83954935
31	kidney morphogenesis (GO:0060993)	2.82948366
32	cAMP catabolic process (GO:0006198)	2.79608677
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.78942021
34	positive regulation of defense response to virus by host (GO:0002230)	2.78888356
35	spinal cord motor neuron differentiation (GO:0021522)	2.74513014
36	negative regulation of telomere maintenance (GO:0032205)	2.74467587
37	membrane repolarization during action potential (GO:0086011)	2.74262659
38	tryptophan metabolic process (GO:0006568)	2.72266300
39	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.71743198
40	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.71743198
41	neural tube formation (GO:0001841)	2.71737101
42	cellular ketone body metabolic process (GO:0046950)	2.66967921
43	positive regulation of CREB transcription factor activity (GO:0032793)	2.66355590
44	cornea development in camera-type eye (GO:0061303)	2.65581860
45	regulation of gene silencing by RNA (GO:0060966)	2.63140452
46	regulation of posttranscriptional gene silencing (GO:0060147)	2.63140452
47	regulation of gene silencing by miRNA (GO:0060964)	2.63140452
48	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.60980592
49	negative regulation of mast cell activation (GO:0033004)	2.60311437
50	positive regulation of fatty acid oxidation (GO:0046321)	2.58489576
51	cilium or flagellum-dependent cell motility (GO:0001539)	2.57999288
52	negative regulation of systemic arterial blood pressure (GO:0003085)	2.56128514
53	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.56093851
54	reflex (GO:0060004)	2.55535369
55	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.54760837
56	indole-containing compound metabolic process (GO:0042430)	2.54424477
57	protein import into peroxisome matrix (GO:0016558)	2.53975874
58	oxidative demethylation (GO:0070989)	2.53231734
59	startle response (GO:0001964)	2.51426460
60	cyclic nucleotide catabolic process (GO:0009214)	2.51297819
61	nephron tubule morphogenesis (GO:0072078)	2.50691985
62	nephron epithelium morphogenesis (GO:0072088)	2.50691985
63	cardiovascular system development (GO:0072358)	2.49230534
64	snRNA transcription (GO:0009301)	2.47148463
65	action potential (GO:0001508)	2.46804422
66	regulation of action potential (GO:0098900)	2.46797444
67	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46590016
68	peristalsis (GO:0030432)	2.46304036
69	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.45563589
70	establishment of protein localization to Golgi (GO:0072600)	2.44839787
71	serotonin metabolic process (GO:0042428)	2.44658924
72	head development (GO:0060322)	2.41396528
73	axoneme assembly (GO:0035082)	2.40829222
74	synaptic transmission, cholinergic (GO:0007271)	2.40108135
75	replicative senescence (GO:0090399)	2.39914043
76	adaptation of signaling pathway (GO:0023058)	2.39778907
77	epithelial cilium movement (GO:0003351)	2.38793858
78	water-soluble vitamin biosynthetic process (GO:0042364)	2.37952768
79	primary amino compound metabolic process (GO:1901160)	2.36610549
80	positive regulation of fatty acid transport (GO:2000193)	2.34858723
81	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.33763689
82	positive regulation of developmental pigmentation (GO:0048087)	2.33137960
83	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.32857086
84	protein polyglutamylation (GO:0018095)	2.32544263
85	DNA methylation involved in gamete generation (GO:0043046)	2.32352849
86	protein K11-linked deubiquitination (GO:0035871)	2.32211905
87	ketone body metabolic process (GO:1902224)	2.32135216
88	rRNA catabolic process (GO:0016075)	2.31515859
89	protein K48-linked deubiquitination (GO:0071108)	2.31404190
90	NAD biosynthetic process (GO:0009435)	2.31371797
91	cell proliferation in forebrain (GO:0021846)	2.29775055
92	somite development (GO:0061053)	2.28660427
93	reciprocal DNA recombination (GO:0035825)	2.26594966
94	reciprocal meiotic recombination (GO:0007131)	2.26594966
95	regulation of membrane repolarization (GO:0060306)	2.26263590
96	regulation of mesoderm development (GO:2000380)	2.25725950
97	positive regulation of protein kinase C signaling (GO:0090037)	2.22643186
98	regulation of pigment cell differentiation (GO:0050932)	2.22096160
99	regulation of telomere maintenance (GO:0032204)	2.21911165
100	neuromuscular synaptic transmission (GO:0007274)	2.20781937

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.63494273
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.21286568
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.93149328
4	VDR_22108803_ChIP-Seq_LS180_Human	2.69038825
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68114499
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.64687857
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.29842087
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28083659
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26216060
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90172036
11	TAF15_26573619_Chip-Seq_HEK293_Human	1.87240693
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86036125
13	EWS_26573619_Chip-Seq_HEK293_Human	1.84801662
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.79704460
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.79330091
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.78042705
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74588136
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70944723
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67367990
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.66472159
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64566381
22	FUS_26573619_Chip-Seq_HEK293_Human	1.62693803
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61953289
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.61637056
25	STAT3_23295773_ChIP-Seq_U87_Human	1.60800333
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59312309
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59312309
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.57932453
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56689162
30	P300_19829295_ChIP-Seq_ESCs_Human	1.56353109
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53859802
32	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.53813623
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.47470196
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.46379825
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44675179
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.43328480
37	TCF4_23295773_ChIP-Seq_U87_Human	1.42813868
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.36636550
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35514367
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35285583
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33837714
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.32741492
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32057324
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30027041
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28641727
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28019314
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27339112
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26486813
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22277665
50	AR_25329375_ChIP-Seq_VCAP_Human	1.22168009
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.21269719
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21120661
53	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.19997698
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19377992
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.17343112
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16516417
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15448557
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14113603
59	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.13663480
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.11015497
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11015497
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10790495
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09840418
64	TP53_16413492_ChIP-PET_HCT116_Human	1.09500485
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08992870
66	AHR_22903824_ChIP-Seq_MCF-7_Human	1.08867545
67	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.07344636
68	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07210453
69	ERA_21632823_ChIP-Seq_H3396_Human	1.06616503
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.03705633
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02926519
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02692586
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02418038
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01968486
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.01275743
76	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.01222211
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01067465
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.00803178
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00266925
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00101401
81	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.00090986
82	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99912927
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99432867
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98890327
85	NCOR_22424771_ChIP-Seq_293T_Human	0.98678805
86	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.98110914
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97853217
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97170310
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96925815
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96925815
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95655605
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94763031
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94763031
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94712886
95	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93946611
96	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93744981
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93465212
98	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.91277463
99	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90958006
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90384586

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.31553195
2	MP0001986_abnormal_taste_sensitivity	3.00444847
3	MP0005174_abnormal_tail_pigmentation	2.96823143
4	MP0003646_muscle_fatigue	2.94654781
5	MP0003136_yellow_coat_color	2.87787857
6	MP0001968_abnormal_touch/_nociception	2.63206207
7	MP0004142_abnormal_muscle_tone	2.30920013
8	MP0008877_abnormal_DNA_methylation	2.27178785
9	MP0004130_abnormal_muscle_cell	2.23141142
10	MP0005551_abnormal_eye_electrophysiolog	2.15162548
11	MP0002837_dystrophic_cardiac_calcinosis	2.04079652
12	MP0004043_abnormal_pH_regulation	1.97470398
13	MP0002653_abnormal_ependyma_morphology	1.88428532
14	MP0009046_muscle_twitch	1.88022794
15	MP0003195_calcinosis	1.87652119
16	MP0002102_abnormal_ear_morphology	1.87634140
17	MP0009745_abnormal_behavioral_response	1.83209091
18	MP0002736_abnormal_nociception_after	1.78671028
19	MP0002638_abnormal_pupillary_reflex	1.77176324
20	MP0004145_abnormal_muscle_electrophysio	1.74748953
21	MP0002160_abnormal_reproductive_system	1.73542119
22	MP0003787_abnormal_imprinting	1.70622049
23	MP0008872_abnormal_physiological_respon	1.69635167
24	MP0002876_abnormal_thyroid_physiology	1.65893241
25	MP0005423_abnormal_somatic_nervous	1.65870253
26	MP0001485_abnormal_pinna_reflex	1.64750781
27	MP0002272_abnormal_nervous_system	1.63181383
28	MP0000427_abnormal_hair_cycle	1.61480816
29	MP0005171_absent_coat_pigmentation	1.58343642
30	MP0002735_abnormal_chemical_nociception	1.57107097
31	MP0001501_abnormal_sleep_pattern	1.55915971
32	MP0004885_abnormal_endolymph	1.54725547
33	MP0005646_abnormal_pituitary_gland	1.52857560
34	MP0002064_seizures	1.51880653
35	MP0001486_abnormal_startle_reflex	1.46616244
36	MP0002928_abnormal_bile_duct	1.37743475
37	MP0001188_hyperpigmentation	1.37360245
38	MP0004215_abnormal_myocardial_fiber	1.37346410
39	MP0001502_abnormal_circadian_rhythm	1.36492610
40	MP0002572_abnormal_emotion/affect_behav	1.36438720
41	MP0000015_abnormal_ear_pigmentation	1.35850579
42	MP0005253_abnormal_eye_physiology	1.35745494
43	MP0005389_reproductive_system_phenotype	1.34572795
44	MP0001970_abnormal_pain_threshold	1.32231632
45	MP0003635_abnormal_synaptic_transmissio	1.30785146
46	MP0006072_abnormal_retinal_apoptosis	1.30727335
47	MP0004133_heterotaxia	1.30723208
48	MP0004147_increased_porphyrin_level	1.30483310
49	MP0002063_abnormal_learning/memory/cond	1.28435065
50	MP0008875_abnormal_xenobiotic_pharmacok	1.27520916
51	MP0000631_abnormal_neuroendocrine_gland	1.25158592
52	MP0002067_abnormal_sensory_capabilities	1.24774871
53	MP0002138_abnormal_hepatobiliary_system	1.20999449
54	MP0004381_abnormal_hair_follicle	1.18678721
55	MP0005386_behavior/neurological_phenoty	1.17275546
56	MP0004924_abnormal_behavior	1.17275546
57	MP0002733_abnormal_thermal_nociception	1.15704981
58	MP0005645_abnormal_hypothalamus_physiol	1.14080593
59	MP0000383_abnormal_hair_follicle	1.12873958
60	MP0000230_abnormal_systemic_arterial	1.11995056
61	MP0006292_abnormal_olfactory_placode	1.09838281
62	MP0008775_abnormal_heart_ventricle	1.09778434
63	MP0006276_abnormal_autonomic_nervous	1.06089892
64	MP0002557_abnormal_social/conspecific_i	1.05249938
65	MP0010386_abnormal_urinary_bladder	1.03300214
66	MP0008961_abnormal_basal_metabolism	1.03181030
67	MP0005083_abnormal_biliary_tract	1.02545256
68	MP0001919_abnormal_reproductive_system	0.99773104
69	MP0003011_delayed_dark_adaptation	0.99509517
70	MP0002095_abnormal_skin_pigmentation	0.98277276
71	MP0008057_abnormal_DNA_replication	0.94847619
72	MP0003137_abnormal_impulse_conducting	0.94137912
73	MP0005167_abnormal_blood-brain_barrier	0.89068738
74	MP0005448_abnormal_energy_balance	0.86510483
75	MP0005195_abnormal_posterior_eye	0.85952671
76	MP0002734_abnormal_mechanical_nocicepti	0.83671488
77	MP0002938_white_spotting	0.83545792
78	MP0001765_abnormal_ion_homeostasis	0.82697406
79	MP0005671_abnormal_response_to	0.82545004
80	MP0001756_abnormal_urination	0.82456514
81	MP0003879_abnormal_hair_cell	0.82187870
82	MP0001440_abnormal_grooming_behavior	0.80759906
83	MP0003045_fibrosis	0.78726672
84	MP0004085_abnormal_heartbeat	0.78504744
85	MP0000685_abnormal_immune_system	0.77922698
86	MP0002752_abnormal_somatic_nervous	0.77408092
87	MP0010329_abnormal_lipoprotein_level	0.75417872
88	MP0000470_abnormal_stomach_morphology	0.75379985
89	MP0000026_abnormal_inner_ear	0.74398116
90	MP0003880_abnormal_central_pattern	0.73580005
91	MP0008995_early_reproductive_senescence	0.73275939
92	MP0004742_abnormal_vestibular_system	0.72545985
93	MP0005084_abnormal_gallbladder_morpholo	0.72539427
94	MP0002909_abnormal_adrenal_gland	0.72403667
95	MP0001984_abnormal_olfaction	0.72266436
96	MP0000538_abnormal_urinary_bladder	0.72128995
97	MP0001800_abnormal_humoral_immune	0.71709069
98	MP0000778_abnormal_nervous_system	0.70540615
99	MP0002184_abnormal_innervation	0.69967303
100	MP0002229_neurodegeneration	0.69724510

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.44205287
2	Genetic anticipation (HP:0003743)	3.95117432
3	Congenital stationary night blindness (HP:0007642)	3.90160219
4	Pancreatic fibrosis (HP:0100732)	3.79554167
5	Nephronophthisis (HP:0000090)	3.76172841
6	Abnormality of midbrain morphology (HP:0002418)	3.66371794
7	Molar tooth sign on MRI (HP:0002419)	3.66371794
8	True hermaphroditism (HP:0010459)	3.41727571
9	Attenuation of retinal blood vessels (HP:0007843)	3.40846021
10	Hyperventilation (HP:0002883)	3.39725055
11	Abnormality of the renal medulla (HP:0100957)	3.29480053
12	Progressive cerebellar ataxia (HP:0002073)	3.29434239
13	Gaze-evoked nystagmus (HP:0000640)	3.18114457
14	Decreased circulating renin level (HP:0003351)	3.04572692
15	Chronic hepatic failure (HP:0100626)	3.04426869
16	Protruding tongue (HP:0010808)	3.03024394
17	Abnormality of the renal cortex (HP:0011035)	2.97518142
18	Clumsiness (HP:0002312)	2.91922916
19	Tubular atrophy (HP:0000092)	2.90416303
20	Type II lissencephaly (HP:0007260)	2.83302341
21	Patellar aplasia (HP:0006443)	2.78855292
22	Polydipsia (HP:0001959)	2.78359789
23	Abnormal drinking behavior (HP:0030082)	2.78359789
24	Cystic liver disease (HP:0006706)	2.75465308
25	Abolished electroretinogram (ERG) (HP:0000550)	2.73587209
26	Aplasia/Hypoplasia of the patella (HP:0006498)	2.71399471
27	Chorioretinal atrophy (HP:0000533)	2.69071743
28	Pendular nystagmus (HP:0012043)	2.56069343
29	Abnormality of alanine metabolism (HP:0010916)	2.52193635
30	Hyperalaninemia (HP:0003348)	2.52193635
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52193635
32	Rib fusion (HP:0000902)	2.50986018
33	Bony spicule pigmentary retinopathy (HP:0007737)	2.50344185
34	Furrowed tongue (HP:0000221)	2.48728724
35	Stomach cancer (HP:0012126)	2.44220586
36	Inability to walk (HP:0002540)	2.44201449
37	Broad-based gait (HP:0002136)	2.39794193
38	Fair hair (HP:0002286)	2.34479751
39	Febrile seizures (HP:0002373)	2.33802193
40	Progressive inability to walk (HP:0002505)	2.33087307
41	Absent/shortened dynein arms (HP:0200106)	2.31580847
42	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.31580847
43	Decreased central vision (HP:0007663)	2.27308910
44	Birth length less than 3rd percentile (HP:0003561)	2.27017913
45	Large for gestational age (HP:0001520)	2.26682716
46	Medial flaring of the eyebrow (HP:0010747)	2.21825889
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20728843
48	Congenital hepatic fibrosis (HP:0002612)	2.18856418
49	Absent speech (HP:0001344)	2.18129084
50	Small hand (HP:0200055)	2.14203614
51	Bulbous nose (HP:0000414)	2.12951268
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.10204335
53	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.09853921
54	Congenital sensorineural hearing impairment (HP:0008527)	2.09185524
55	Abnormality of the renal collecting system (HP:0004742)	2.07988200
56	Abnormality of the pons (HP:0007361)	2.07498540
57	Hypoplasia of the pons (HP:0012110)	2.07313870
58	Polyuria (HP:0000103)	2.06306203
59	Increased corneal curvature (HP:0100692)	2.06081706
60	Keratoconus (HP:0000563)	2.06081706
61	Lissencephaly (HP:0001339)	2.02310789
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98392112
63	Cerebellar dysplasia (HP:0007033)	1.97317772
64	Absent thumb (HP:0009777)	1.95064811
65	Male pseudohermaphroditism (HP:0000037)	1.93796017
66	Impaired smooth pursuit (HP:0007772)	1.91862825
67	Sclerocornea (HP:0000647)	1.87721598
68	Prolonged QT interval (HP:0001657)	1.85643272
69	Duplicated collecting system (HP:0000081)	1.85440059
70	Widely spaced teeth (HP:0000687)	1.83440292
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81277082
72	Abnormal biliary tract physiology (HP:0012439)	1.80870639
73	Bile duct proliferation (HP:0001408)	1.80870639
74	Generalized hypopigmentation of hair (HP:0011358)	1.79760812
75	Hamartoma of the eye (HP:0010568)	1.79710935
76	Tented upper lip vermilion (HP:0010804)	1.79583930
77	Gait imbalance (HP:0002141)	1.77981570
78	Hemiparesis (HP:0001269)	1.77976733
79	Concave nail (HP:0001598)	1.76333435
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73334733
81	Anencephaly (HP:0002323)	1.73061476
82	Abnormality of binocular vision (HP:0011514)	1.69953483
83	Diplopia (HP:0000651)	1.69953483
84	Ketosis (HP:0001946)	1.69838427
85	Hypoalbuminemia (HP:0003073)	1.68560902
86	Abnormal albumin level (HP:0012116)	1.68560902
87	Abnormal EKG (HP:0003115)	1.68425929
88	Tachypnea (HP:0002789)	1.68164815
89	Abnormality of the nasal septum (HP:0000419)	1.67927329
90	Abnormal respiratory motile cilium morphology (HP:0005938)	1.66923966
91	Abnormal respiratory epithelium morphology (HP:0012253)	1.66923966
92	Renal cortical cysts (HP:0000803)	1.66631286
93	Short chin (HP:0000331)	1.66436870
94	Syncope (HP:0001279)	1.65050060
95	Adactyly (HP:0009776)	1.63448237
96	Epileptic encephalopathy (HP:0200134)	1.63345555
97	Congenital primary aphakia (HP:0007707)	1.61543230
98	Abnormal urine output (HP:0012590)	1.60026894
99	Abnormality of renin-angiotensin system (HP:0000847)	1.59975405
100	Abnormal ciliary motility (HP:0012262)	1.59957655

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.26723911
2	BMPR1B	3.01192981
3	ACVR1B	2.89950867
4	ADRBK2	2.86645040
5	TLK1	2.67682061
6	WNK4	2.52939817
7	PINK1	2.46093190
8	ZAK	2.09291740
9	GRK1	2.08494907
10	TAOK3	2.08396689
11	MAPK13	1.97021251
12	DAPK2	1.66591161
13	MAPK15	1.65553008
14	NTRK3	1.56924075
15	INSRR	1.52796140
16	WNK3	1.45852088
17	PAK3	1.45543153
18	NUAK1	1.40850253
19	CASK	1.40464219
20	MAP3K4	1.39703086
21	AKT3	1.38842334
22	TXK	1.36223922
23	ADRBK1	1.31472199
24	SGK2	1.18857484
25	SIK2	1.18199717
26	CAMKK2	1.17378556
27	MAP4K2	1.15713504
28	MAPKAPK3	1.11907182
29	MAP2K6	1.11870218
30	PIK3CA	1.10934191
31	OXSR1	1.10165980
32	TNIK	1.09352638
33	BLK	1.05798737
34	SGK223	1.02422532
35	SGK494	1.02422532
36	NLK	1.02264906
37	OBSCN	0.99769572
38	MARK1	0.96334519
39	WNK1	0.93949090
40	PHKG1	0.89826081
41	PHKG2	0.89826081
42	STK39	0.89759582
43	FGFR2	0.89678545
44	TEC	0.89203856
45	NTRK2	0.88501854
46	TNK2	0.88473519
47	STK11	0.87580022
48	MKNK2	0.86491532
49	PTK2B	0.83310031
50	PRKD2	0.82681362
51	RPS6KA6	0.82372894
52	TGFBR1	0.78555377
53	SYK	0.78272212
54	MAP2K7	0.77923569
55	MAP2K4	0.76602193
56	IKBKB	0.74788749
57	ITK	0.72418180
58	CAMK1D	0.70772932
59	MAPK12	0.70427645
60	TRPM7	0.70395367
61	PRKAA1	0.69436338
62	KIT	0.69076846
63	CAMK1	0.67724341
64	PRKCG	0.67508849
65	MARK3	0.66790431
66	MAP4K1	0.66688720
67	PRKAA2	0.66559471
68	PKN1	0.66419573
69	PRKCQ	0.64706708
70	PRKCE	0.59563869
71	MUSK	0.58967742
72	MAP3K7	0.58027667
73	GRK6	0.57657244
74	SGK3	0.56074379
75	BTK	0.55982809
76	MAPK11	0.55832974
77	CAMKK1	0.54992050
78	GRK7	0.54357617
79	CAMK4	0.54312818
80	CHUK	0.54092391
81	PRKCH	0.52955570
82	TYRO3	0.48802927
83	IKBKE	0.47043660
84	LYN	0.46578708
85	PRKACA	0.46536800
86	CAMK1G	0.45589297
87	CAMK2A	0.45505846
88	SGK1	0.45213350
89	PRKCZ	0.42014978
90	ERBB2	0.41198113
91	MARK2	0.41108359
92	DYRK1A	0.39382011
93	MAPK8	0.39150301
94	DYRK2	0.39068096
95	FES	0.38835089
96	CSNK1D	0.38548063
97	STK38L	0.37789141
98	LCK	0.37629713
99	PRKD1	0.36513846
100	RPS6KA2	0.36469422

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.03477102
2	Phototransduction_Homo sapiens_hsa04744	2.47799141
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.46989587
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.46514489
5	Nicotine addiction_Homo sapiens_hsa05033	2.42327423
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.42281652
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29792652
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24204147
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.24187566
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04827925
11	Morphine addiction_Homo sapiens_hsa05032	1.88505576
12	Taste transduction_Homo sapiens_hsa04742	1.82604755
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76934514
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73222714
15	Circadian entrainment_Homo sapiens_hsa04713	1.60266484
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.57561531
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57004002
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56981788
19	ABC transporters_Homo sapiens_hsa02010	1.55158503
20	Butanoate metabolism_Homo sapiens_hsa00650	1.55134522
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.46575314
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.45330938
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.40121740
24	Insulin secretion_Homo sapiens_hsa04911	1.40015989
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.39590799
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.38422910
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.36123358
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.33364214
29	Serotonergic synapse_Homo sapiens_hsa04726	1.27739964
30	Homologous recombination_Homo sapiens_hsa03440	1.26471134
31	Olfactory transduction_Homo sapiens_hsa04740	1.20316201
32	GABAergic synapse_Homo sapiens_hsa04727	1.16459865
33	Cholinergic synapse_Homo sapiens_hsa04725	1.14649040
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.08423255
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08219556
36	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.07658839
37	Circadian rhythm_Homo sapiens_hsa04710	1.05514201
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.04614763
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.04184235
40	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.02235759
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02117674
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99384950
43	Gastric acid secretion_Homo sapiens_hsa04971	0.96846689
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96487250
45	Regulation of autophagy_Homo sapiens_hsa04140	0.96374355
46	Renin secretion_Homo sapiens_hsa04924	0.93699659
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93357066
48	Basal transcription factors_Homo sapiens_hsa03022	0.91330052
49	Histidine metabolism_Homo sapiens_hsa00340	0.89191970
50	Salivary secretion_Homo sapiens_hsa04970	0.88246454
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.87610995
52	cAMP signaling pathway_Homo sapiens_hsa04024	0.82565079
53	Long-term depression_Homo sapiens_hsa04730	0.81981934
54	Lysine degradation_Homo sapiens_hsa00310	0.80420131
55	Sulfur relay system_Homo sapiens_hsa04122	0.79921950
56	Type II diabetes mellitus_Homo sapiens_hsa04930	0.79009563
57	Caffeine metabolism_Homo sapiens_hsa00232	0.78956994
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76966660
59	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.76797950
60	RNA polymerase_Homo sapiens_hsa03020	0.74485754
61	Amphetamine addiction_Homo sapiens_hsa05031	0.71914862
62	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.71501305
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70814854
64	Cocaine addiction_Homo sapiens_hsa05030	0.70317159
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65658409
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64041513
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63497325
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63032139
69	MAPK signaling pathway_Homo sapiens_hsa04010	0.62926522
70	Retinol metabolism_Homo sapiens_hsa00830	0.62660100
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61693256
72	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.60903316
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59849395
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.59398515
75	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.58695974
76	Peroxisome_Homo sapiens_hsa04146	0.58231758
77	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.57456269
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54249437
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.53554252
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.51349496
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50031698
82	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.49507520
83	Insulin resistance_Homo sapiens_hsa04931	0.48326984
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.47587486
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46584854
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.45775262
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.43345390
88	Mineral absorption_Homo sapiens_hsa04978	0.41180891
89	Platelet activation_Homo sapiens_hsa04611	0.41025513
90	FoxO signaling pathway_Homo sapiens_hsa04068	0.40288397
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.38957473
92	Asthma_Homo sapiens_hsa05310	0.37207991
93	Ras signaling pathway_Homo sapiens_hsa04014	0.36228992
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34118093
95	RNA degradation_Homo sapiens_hsa03018	0.33607079
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33086175
97	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.32971447
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.31041663
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30586304
100	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30026882

SCAND2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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