SCAND3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)8.69206513
2positive regulation of protein deacetylation (GO:0090312)5.83071638
3retinal ganglion cell axon guidance (GO:0031290)5.79334758
4detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.59584452
5cell wall macromolecule catabolic process (GO:0016998)5.56664967
6RNA destabilization (GO:0050779)5.49804173
7alkaloid metabolic process (GO:0009820)5.46584391
8regulation of action potential (GO:0098900)5.43749351
9neurotransmitter-gated ion channel clustering (GO:0072578)5.35742993
10somite rostral/caudal axis specification (GO:0032525)4.94750926
11negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)4.93350486
12positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.83441513
13short-term memory (GO:0007614)4.81010135
14detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.74251731
15forebrain neuron development (GO:0021884)4.72765286
16left/right axis specification (GO:0070986)4.71538871
17cell wall macromolecule metabolic process (GO:0044036)4.63200879
18protein localization to cilium (GO:0061512)4.49002761
19protein localization to synapse (GO:0035418)4.44006598
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.40912387
21neuron recognition (GO:0008038)4.38595130
22positive regulation of dendritic spine morphogenesis (GO:0061003)4.34971697
23behavioral response to ethanol (GO:0048149)4.26987979
24meiotic chromosome segregation (GO:0045132)4.22933676
25positive regulation of sodium ion transmembrane transport (GO:1902307)4.20938744
26exploration behavior (GO:0035640)4.18913215
27negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.08140738
28tachykinin receptor signaling pathway (GO:0007217)3.97011503
29homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.84811305
30positive regulation of amino acid transport (GO:0051957)3.83943658
31membrane budding (GO:0006900)3.76928751
32axon regeneration (GO:0031103)3.75519490
33gamma-aminobutyric acid transport (GO:0015812)3.70900076
34regulation of protein deacetylation (GO:0090311)3.68761989
35positive regulation of vesicle fusion (GO:0031340)3.64739899
36oxidative demethylation (GO:0070989)3.60609643
37histone H2A ubiquitination (GO:0033522)3.55650148
38paraxial mesoderm development (GO:0048339)3.51710232
39calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.49760910
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44974414
41histone H2A monoubiquitination (GO:0035518)3.44041919
42layer formation in cerebral cortex (GO:0021819)3.43126090
43neuronal action potential (GO:0019228)3.42303168
44negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.41213457
45urinary tract smooth muscle contraction (GO:0014848)3.40450608
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.38579459
47regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.35730235
48regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.35730235
49behavioral response to cocaine (GO:0048148)3.33163441
50glutamate receptor signaling pathway (GO:0007215)3.29331003
51positive regulation of uterine smooth muscle contraction (GO:0070474)3.29304408
52cellular ketone body metabolic process (GO:0046950)3.24773596
53response to auditory stimulus (GO:0010996)3.22494610
54positive regulation of dendritic spine development (GO:0060999)3.21120068
55positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20353242
56positive regulation of amine transport (GO:0051954)3.16526911
57response to folic acid (GO:0051593)3.16390520
58neuronal action potential propagation (GO:0019227)3.15981186
59positive regulation of vascular permeability (GO:0043117)3.15153215
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14546660
61central nervous system neuron development (GO:0021954)3.11369403
62aggressive behavior (GO:0002118)3.10875611
63membrane depolarization during action potential (GO:0086010)3.09159330
64positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.04340948
65epoxygenase P450 pathway (GO:0019373)3.04221541
66DNA ligation (GO:0006266)3.04200693
67intraciliary transport (GO:0042073)3.02641238
68nerve growth factor signaling pathway (GO:0038180)3.00395173
69negative regulation of chemotaxis (GO:0050922)2.99565219
70regulation of vesicle fusion (GO:0031338)2.99193773
71drug catabolic process (GO:0042737)2.98630349
72secondary metabolite biosynthetic process (GO:0044550)2.98625340
73regulation of energy homeostasis (GO:2000505)2.98303686
74substrate-independent telencephalic tangential migration (GO:0021826)2.97053462
75substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.97053462
76axon development (GO:0061564)2.96841284
77gastrulation with mouth forming second (GO:0001702)2.96631832
78cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.96550154
79positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.95181824
80cell-cell adhesion (GO:0098609)2.95098593
81righting reflex (GO:0060013)2.94534678
82sympathetic nervous system development (GO:0048485)2.93180400
83ketone body metabolic process (GO:1902224)2.90830371
84snRNA transcription (GO:0009301)2.90189109
85interkinetic nuclear migration (GO:0022027)2.89111674
86ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.85829546
87synapse assembly (GO:0007416)2.85029157
88hemoglobin metabolic process (GO:0020027)2.84802778
89long-term memory (GO:0007616)2.83433013
90omega-hydroxylase P450 pathway (GO:0097267)2.82266419
91response to histamine (GO:0034776)2.81638725
92positive regulation of cellular amide metabolic process (GO:0034250)2.80803131
93regulation of beta-amyloid formation (GO:1902003)2.80412398
94hydrogen peroxide biosynthetic process (GO:0050665)2.80184078
95ADP metabolic process (GO:0046031)2.78624672
96interferon-gamma production (GO:0032609)2.78586401
97chemosensory behavior (GO:0007635)2.75640877
98positive regulation of synapse maturation (GO:0090129)2.75276692
99positive regulation of membrane potential (GO:0045838)2.75077250
100response to misfolded protein (GO:0051788)2.74787031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse6.35199808
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.06774782
3GBX2_23144817_ChIP-Seq_PC3_Human3.29097688
4FUS_26573619_Chip-Seq_HEK293_Human3.11788948
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11253772
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.04138153
7EZH2_22144423_ChIP-Seq_EOC_Human2.91952399
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85254218
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78452672
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.71051790
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52060054
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37614215
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.29683822
14ZNF274_21170338_ChIP-Seq_K562_Hela2.13046708
15VDR_22108803_ChIP-Seq_LS180_Human2.12536941
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.10746873
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09691012
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05291346
19SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.04699828
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00373937
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98008355
22TAF15_26573619_Chip-Seq_HEK293_Human1.93020337
23CBP_20019798_ChIP-Seq_JUKART_Human1.87176087
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87176087
25SMAD4_21799915_ChIP-Seq_A2780_Human1.86709970
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86383150
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.83283453
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.78214610
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71471267
30P300_19829295_ChIP-Seq_ESCs_Human1.70980102
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.70338888
32STAT3_23295773_ChIP-Seq_U87_Human1.67393723
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65313447
34TCF4_23295773_ChIP-Seq_U87_Human1.62451239
35REST_21632747_ChIP-Seq_MESCs_Mouse1.61470712
36RNF2_27304074_Chip-Seq_NSC_Mouse1.61294674
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.59402337
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53433238
39BCAT_22108803_ChIP-Seq_LS180_Human1.48933813
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48714076
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44972514
42EWS_26573619_Chip-Seq_HEK293_Human1.43746693
43AR_25329375_ChIP-Seq_VCAP_Human1.43651019
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41971446
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41896873
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39644628
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36505121
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35154788
49KDM2B_26808549_Chip-Seq_REH_Human1.34699785
50RUNX2_22187159_ChIP-Seq_PCA_Human1.34520658
51TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32229245
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32150966
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30873291
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29434587
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29231173
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.28395015
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.28121452
58ER_23166858_ChIP-Seq_MCF-7_Human1.27968338
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.26346246
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26286965
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.26285833
62TP53_22573176_ChIP-Seq_HFKS_Human1.25143114
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24625673
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23104979
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22567590
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22567590
67DROSHA_22980978_ChIP-Seq_HELA_Human1.20823813
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.20310854
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.20239476
70AR_21572438_ChIP-Seq_LNCaP_Human1.19882431
71TP53_16413492_ChIP-PET_HCT116_Human1.19779666
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18265042
73AHR_22903824_ChIP-Seq_MCF-7_Human1.15654232
74TCF4_22108803_ChIP-Seq_LS180_Human1.15141799
75IGF1R_20145208_ChIP-Seq_DFB_Human1.14180903
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.12667184
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10681495
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10009777
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.09501684
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09497490
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09333279
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.08111395
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.08086458
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07827663
85JUN_21703547_ChIP-Seq_K562_Human1.05271789
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03514600
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03234135
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02787439
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01683128
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01460041
91HTT_18923047_ChIP-ChIP_STHdh_Human0.99403059
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98127130
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97708322
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97341782
95SOX2_19829295_ChIP-Seq_ESCs_Human0.97146563
96NANOG_19829295_ChIP-Seq_ESCs_Human0.97146563
97NCOR_22424771_ChIP-Seq_293T_Human0.96672306
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96378775
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.96273023
100TP53_18474530_ChIP-ChIP_U2OS_Human0.95326436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.44820817
2MP0005367_renal/urinary_system_phenotyp4.43024948
3MP0000516_abnormal_urinary_system4.43024948
4MP0002736_abnormal_nociception_after3.77285057
5MP0004859_abnormal_synaptic_plasticity3.11585548
6MP0001968_abnormal_touch/_nociception3.10710876
7MP0005670_abnormal_white_adipose3.09176973
8MP0004270_analgesia2.98006296
9MP0002735_abnormal_chemical_nociception2.89009416
10MP0002837_dystrophic_cardiac_calcinosis2.78924339
11MP0003890_abnormal_embryonic-extraembry2.76738240
12MP0001529_abnormal_vocalization2.66372560
13MP0003183_abnormal_peptide_metabolism2.51201125
14MP0009046_muscle_twitch2.32643674
15MP0000569_abnormal_digit_pigmentation2.28862735
16MP0008057_abnormal_DNA_replication2.22106230
17MP0001501_abnormal_sleep_pattern2.07561437
18MP0002734_abnormal_mechanical_nocicepti2.07073520
19MP0004133_heterotaxia2.05897404
20MP0000372_irregular_coat_pigmentation2.05416931
21MP0003195_calcinosis2.01339915
22MP0004043_abnormal_pH_regulation1.97999397
23MP0001486_abnormal_startle_reflex1.87932732
24MP0002102_abnormal_ear_morphology1.77513243
25MP0002572_abnormal_emotion/affect_behav1.77166003
26MP0006292_abnormal_olfactory_placode1.75253939
27MP0009745_abnormal_behavioral_response1.71580121
28MP0008961_abnormal_basal_metabolism1.62381447
29MP0003635_abnormal_synaptic_transmissio1.55670611
30MP0001485_abnormal_pinna_reflex1.54434363
31MP0002063_abnormal_learning/memory/cond1.51512154
32MP0002272_abnormal_nervous_system1.49587448
33MP0003787_abnormal_imprinting1.49334500
34MP0000955_abnormal_spinal_cord1.46986787
35MP0002067_abnormal_sensory_capabilities1.46949645
36MP0002938_white_spotting1.40009320
37MP0008872_abnormal_physiological_respon1.39935781
38MP0005379_endocrine/exocrine_gland_phen1.35900567
39MP0008875_abnormal_xenobiotic_pharmacok1.33552381
40MP0000631_abnormal_neuroendocrine_gland1.33465592
41MP0004782_abnormal_surfactant_physiolog1.32249315
42MP0003879_abnormal_hair_cell1.30195629
43MP0000778_abnormal_nervous_system1.29523557
44MP0000534_abnormal_ureter_morphology1.28986801
45MP0006276_abnormal_autonomic_nervous1.26528342
46MP0002064_seizures1.25959222
47MP0005386_behavior/neurological_phenoty1.20314507
48MP0004924_abnormal_behavior1.20314507
49MP0003646_muscle_fatigue1.16326163
50MP0005248_abnormal_Harderian_gland1.14759235
51MP0004142_abnormal_muscle_tone1.14469921
52MP0003221_abnormal_cardiomyocyte_apopto1.12027676
53MP0005551_abnormal_eye_electrophysiolog1.11942252
54MP0001970_abnormal_pain_threshold1.09439577
55MP0001440_abnormal_grooming_behavior1.06370780
56MP0003878_abnormal_ear_physiology1.05035158
57MP0005377_hearing/vestibular/ear_phenot1.05035158
58MP0002557_abnormal_social/conspecific_i1.04668892
59MP0002234_abnormal_pharynx_morphology1.04280746
60MP0002751_abnormal_autonomic_nervous1.02881739
61MP0003121_genomic_imprinting1.01443172
62MP0003119_abnormal_digestive_system0.99494825
63MP0002882_abnormal_neuron_morphology0.99301330
64MP0005253_abnormal_eye_physiology0.98122484
65MP0003633_abnormal_nervous_system0.96625116
66MP0005174_abnormal_tail_pigmentation0.95297717
67MP0005448_abnormal_energy_balance0.94580937
68MP0010329_abnormal_lipoprotein_level0.92324752
69MP0002184_abnormal_innervation0.92111706
70MP0006072_abnormal_retinal_apoptosis0.91244334
71MP0008569_lethality_at_weaning0.88695717
72MP0001984_abnormal_olfaction0.88613070
73MP0002066_abnormal_motor_capabilities/c0.88463328
74MP0000566_synostosis0.87379666
75MP0002152_abnormal_brain_morphology0.85527698
76MP0003123_paternal_imprinting0.85025036
77MP0010368_abnormal_lymphatic_system0.79976858
78MP0002229_neurodegeneration0.79791450
79MP0003122_maternal_imprinting0.79179310
80MP0004215_abnormal_myocardial_fiber0.77895232
81MP0001764_abnormal_homeostasis0.75387172
82MP0002277_abnormal_respiratory_mucosa0.75243922
83MP0004885_abnormal_endolymph0.73740291
84MP0004742_abnormal_vestibular_system0.72743835
85MP0002752_abnormal_somatic_nervous0.72331881
86MP0000383_abnormal_hair_follicle0.72160168
87MP0009780_abnormal_chondrocyte_physiolo0.72069480
88MP0002733_abnormal_thermal_nociception0.70710690
89MP0001905_abnormal_dopamine_level0.69091448
90MP0004811_abnormal_neuron_physiology0.65137932
91MP0005646_abnormal_pituitary_gland0.62134358
92MP0003631_nervous_system_phenotype0.61947526
93MP0008874_decreased_physiological_sensi0.61236137
94MP0005195_abnormal_posterior_eye0.60233629
95MP0000678_abnormal_parathyroid_gland0.58235320
96MP0002069_abnormal_eating/drinking_beha0.57686181
97MP0002095_abnormal_skin_pigmentation0.57395398
98MP0001756_abnormal_urination0.56998688
99MP0000015_abnormal_ear_pigmentation0.55925933
100MP0003755_abnormal_palate_morphology0.54979318

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)8.28737353
2Febrile seizures (HP:0002373)7.51562717
3Focal motor seizures (HP:0011153)6.36975787
4Rib fusion (HP:0000902)4.34310925
5Methylmalonic acidemia (HP:0002912)4.14623663
6Split foot (HP:0001839)3.77868261
7Intestinal atresia (HP:0011100)3.67456766
8Renal hypoplasia (HP:0000089)3.57710341
9Hyperglycinemia (HP:0002154)3.52366946
10Methylmalonic aciduria (HP:0012120)3.16334877
11Focal seizures (HP:0007359)3.16045631
12Medial flaring of the eyebrow (HP:0010747)3.10161081
13Gait imbalance (HP:0002141)3.05728852
14Severe global developmental delay (HP:0011344)3.02110002
15Dialeptic seizures (HP:0011146)3.01037203
16Agitation (HP:0000713)2.98742847
17Hyperventilation (HP:0002883)2.93952340
18Anomalous pulmonary venous return (HP:0010772)2.89865637
19Dyschromatopsia (HP:0007641)2.88265439
20Congenital, generalized hypertrichosis (HP:0004540)2.85831335
21Decreased circulating renin level (HP:0003351)2.85042145
22Complete atrioventricular canal defect (HP:0001674)2.80743652
23Central scotoma (HP:0000603)2.73172623
24Median cleft lip (HP:0000161)2.70958353
25Congenital primary aphakia (HP:0007707)2.69043527
26Abnormality of vitamin B metabolism (HP:0004340)2.66081629
27Renal cortical cysts (HP:0000803)2.61659857
28Ankle clonus (HP:0011448)2.59795386
29Broad alveolar ridges (HP:0000187)2.52785752
30Septo-optic dysplasia (HP:0100842)2.52768216
31Abnormality of the labia minora (HP:0012880)2.50558082
32Abnormality of the renal cortex (HP:0011035)2.47402846
33Abnormality of the pulmonary veins (HP:0011718)2.47348045
34Narrow forehead (HP:0000341)2.46934794
35Oligodactyly (HP:0012165)2.43507350
36Abnormality of methionine metabolism (HP:0010901)2.38385732
37Pancreatic fibrosis (HP:0100732)2.37700592
38Long foot (HP:0001833)2.36806377
39Papillary thyroid carcinoma (HP:0002895)2.35753779
40Epidermoid cyst (HP:0200040)2.35438820
41Drooling (HP:0002307)2.33792789
42Atrioventricular canal defect (HP:0006695)2.33494094
43Growth hormone deficiency (HP:0000824)2.28760434
44Abnormality of the vitamin B12 metabolism (HP:0004341)2.28497017
45Poor coordination (HP:0002370)2.27637834
46Gastrointestinal atresia (HP:0002589)2.25617459
47Abnormality of midbrain morphology (HP:0002418)2.25095816
48Molar tooth sign on MRI (HP:0002419)2.25095816
49Nephrogenic diabetes insipidus (HP:0009806)2.24760666
50Hepatoblastoma (HP:0002884)2.24187282
51Abnormality of the axillary hair (HP:0100134)2.23734583
52Abnormality of secondary sexual hair (HP:0009888)2.23734583
53Congenital malformation of the right heart (HP:0011723)2.22500071
54Double outlet right ventricle (HP:0001719)2.22500071
55Hyperkalemia (HP:0002153)2.19918341
56Gaze-evoked nystagmus (HP:0000640)2.18332822
57Generalized tonic-clonic seizures (HP:0002069)2.16871550
58Horizontal nystagmus (HP:0000666)2.16665479
59Facial hemangioma (HP:0000329)2.16073523
60High anterior hairline (HP:0009890)2.14622356
61Excessive salivation (HP:0003781)2.13613155
62Postaxial hand polydactyly (HP:0001162)2.12508729
63Abnormality of the parathyroid morphology (HP:0011766)2.11691567
64Tubulointerstitial nephritis (HP:0001970)2.09357254
65Postaxial foot polydactyly (HP:0001830)2.09284075
66Restlessness (HP:0000711)2.08442688
67Triphalangeal thumb (HP:0001199)2.04504007
68Genital tract atresia (HP:0001827)2.04126575
69Thyroid carcinoma (HP:0002890)2.03538908
70True hermaphroditism (HP:0010459)2.02688661
71Vaginal atresia (HP:0000148)2.01511727
72Autoamputation (HP:0001218)1.99935234
73Hypoplastic pelvis (HP:0008839)1.98395548
74Abnormality of homocysteine metabolism (HP:0010919)1.96367475
75Homocystinuria (HP:0002156)1.96367475
76Abnormal auditory evoked potentials (HP:0006958)1.96170347
77Oligodactyly (hands) (HP:0001180)1.90210028
78Arthropathy (HP:0003040)1.89735727
79Colon cancer (HP:0003003)1.88452022
80Absent speech (HP:0001344)1.88287919
81Amblyopia (HP:0000646)1.86932107
82Polyphagia (HP:0002591)1.85012371
83Status epilepticus (HP:0002133)1.84406820
84Abnormality of serum amino acid levels (HP:0003112)1.84079129
85Progressive cerebellar ataxia (HP:0002073)1.83315307
86Epileptic encephalopathy (HP:0200134)1.82308058
87Pancreatic cysts (HP:0001737)1.81710565
88Abnormal respiratory motile cilium morphology (HP:0005938)1.79246541
89Abnormal respiratory epithelium morphology (HP:0012253)1.79246541
90Spastic gait (HP:0002064)1.75191384
91Hyperaldosteronism (HP:0000859)1.73153185
92Downturned corners of mouth (HP:0002714)1.71613901
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70674422
94Abnormal protein N-linked glycosylation (HP:0012347)1.70674422
95Abnormal protein glycosylation (HP:0012346)1.70674422
96Abnormal glycosylation (HP:0012345)1.70674422
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69926882
98Exotropia (HP:0000577)1.69901070
99Shoulder girdle muscle weakness (HP:0003547)1.69000283
100Choroideremia (HP:0001139)1.68991223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF15.52115797
2FGFR34.93593188
3MAP3K44.50812113
4WNK34.32818541
5MAP2K74.13156906
6MAP3K63.56278054
7DYRK1A2.98867400
8CAMKK22.78020549
9MARK12.69950255
10MAP2K42.62466160
11MAPK132.55581161
12CASK2.50637181
13FRK2.32105328
14TNIK2.25124300
15EPHA42.03685247
16BRSK21.94869963
17EIF2AK31.88308020
18CAMKK11.81859748
19MKNK21.59218443
20NUAK11.12576578
21BCR1.09519863
22TRPM71.09217008
23PRKCG1.02983849
24LATS11.02542486
25PASK1.02122816
26GRK10.99054864
27MAP3K50.92808820
28TRIM280.91106352
29EPHA30.90930169
30DYRK20.90161817
31NTRK10.87776056
32CAMK2B0.81946429
33SGK10.79553932
34CDK30.78606691
35ERBB30.77606442
36UHMK10.77063999
37NTRK30.76952525
38PAK30.72261266
39PLK20.69426317
40DYRK1B0.68775387
41PHKG10.66877256
42PHKG20.66877256
43PKN20.64636919
44CAMK2A0.64305419
45PNCK0.63887034
46BRSK10.63186343
47CSNK1G10.62966882
48PRKACB0.62960092
49CSNK1E0.61459662
50VRK10.59913901
51CSNK1G20.59539912
52PRKCE0.59392513
53DAPK20.58551057
54STK110.58341684
55MAP2K60.57813025
56ADRBK20.57279816
57MAP4K20.56905809
58INSRR0.54087634
59MATK0.54076536
60NTRK20.53641436
61ABL20.48900111
62ADRBK10.48505515
63MAPK120.47266636
64MKNK10.47030136
65CSNK1G30.45192089
66CLK10.42761538
67STK380.42048595
68CSNK1A1L0.40527807
69CAMK40.40238408
70PRKACA0.39978079
71OBSCN0.39695036
72INSR0.39617808
73LIMK10.38508411
74PRKAA20.37439646
75DAPK10.36116273
76EIF2AK20.35286473
77PRKCZ0.34348558
78STK160.33723739
79TYRO30.32426761
80RPS6KA30.31854668
81ABL10.31736537
82MARK20.30406415
83ERBB20.30202916
84PRKCB0.29255055
85SRPK10.28899874
86PRKG10.28354682
87TNK20.27607743
88CAMK2D0.27180105
89ATR0.27009152
90RET0.26891626
91MINK10.26449486
92PRKCA0.25818109
93PRKACG0.24628431
94FGFR10.24483914
95MAP3K70.24421695
96STK38L0.22545886
97CSNK1A10.22134840
98CSNK1D0.20186229
99NME10.20136835
100ERBB40.19727428

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.23292722
2Propanoate metabolism_Homo sapiens_hsa006404.13332008
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.12269533
4Taste transduction_Homo sapiens_hsa047423.90567966
5Cysteine and methionine metabolism_Homo sapiens_hsa002702.99292468
6Nicotine addiction_Homo sapiens_hsa050332.98409619
7Pyruvate metabolism_Homo sapiens_hsa006202.51304696
8Linoleic acid metabolism_Homo sapiens_hsa005912.19085306
9Butanoate metabolism_Homo sapiens_hsa006501.98723789
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.88319537
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88140349
12Glutamatergic synapse_Homo sapiens_hsa047241.76146872
13Steroid biosynthesis_Homo sapiens_hsa001001.64656147
14Non-homologous end-joining_Homo sapiens_hsa034501.59062545
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56759087
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45739362
17Glucagon signaling pathway_Homo sapiens_hsa049221.37655929
18One carbon pool by folate_Homo sapiens_hsa006701.37296135
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36403093
20Morphine addiction_Homo sapiens_hsa050321.36108999
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31344599
22Dopaminergic synapse_Homo sapiens_hsa047281.30113390
23Circadian rhythm_Homo sapiens_hsa047101.28354781
24Long-term depression_Homo sapiens_hsa047301.22388460
25GABAergic synapse_Homo sapiens_hsa047271.21615715
26Circadian entrainment_Homo sapiens_hsa047131.20604920
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17145332
28Basal transcription factors_Homo sapiens_hsa030221.16384616
29Oxidative phosphorylation_Homo sapiens_hsa001901.15489178
30Cardiac muscle contraction_Homo sapiens_hsa042601.12255921
31Type II diabetes mellitus_Homo sapiens_hsa049301.09621250
32Axon guidance_Homo sapiens_hsa043601.06223032
33Retinol metabolism_Homo sapiens_hsa008300.97884688
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96970702
35Insulin secretion_Homo sapiens_hsa049110.94823198
36Tryptophan metabolism_Homo sapiens_hsa003800.93023295
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92664890
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91986886
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87885092
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84309882
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81020239
42Phototransduction_Homo sapiens_hsa047440.80237196
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79835101
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78405565
45Selenocompound metabolism_Homo sapiens_hsa004500.76894501
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76213840
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75745440
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75658511
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.75273825
50Ether lipid metabolism_Homo sapiens_hsa005650.74565860
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74240269
52Nucleotide excision repair_Homo sapiens_hsa034200.74194301
53Fanconi anemia pathway_Homo sapiens_hsa034600.73008452
54Huntingtons disease_Homo sapiens_hsa050160.71099455
55Parkinsons disease_Homo sapiens_hsa050120.64466175
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64437840
57Serotonergic synapse_Homo sapiens_hsa047260.63657606
58Cholinergic synapse_Homo sapiens_hsa047250.63391572
59Cocaine addiction_Homo sapiens_hsa050300.62296588
60Chemical carcinogenesis_Homo sapiens_hsa052040.60680559
61Homologous recombination_Homo sapiens_hsa034400.60556851
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60008853
63Vitamin B6 metabolism_Homo sapiens_hsa007500.59554361
64Amphetamine addiction_Homo sapiens_hsa050310.58966859
65Basal cell carcinoma_Homo sapiens_hsa052170.58648459
66Nitrogen metabolism_Homo sapiens_hsa009100.58229690
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58150710
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57079191
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.55950574
70Folate biosynthesis_Homo sapiens_hsa007900.54827069
71Salivary secretion_Homo sapiens_hsa049700.53963886
72RNA degradation_Homo sapiens_hsa030180.52993548
73Arginine and proline metabolism_Homo sapiens_hsa003300.52511196
74Arginine biosynthesis_Homo sapiens_hsa002200.52006287
75Dorso-ventral axis formation_Homo sapiens_hsa043200.51372107
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50313751
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47520637
78Sulfur metabolism_Homo sapiens_hsa009200.46450098
79AMPK signaling pathway_Homo sapiens_hsa041520.45851848
80cAMP signaling pathway_Homo sapiens_hsa040240.45822839
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45186948
82Alzheimers disease_Homo sapiens_hsa050100.44864615
83Metabolic pathways_Homo sapiens_hsa011000.44753079
84ABC transporters_Homo sapiens_hsa020100.43311416
85Calcium signaling pathway_Homo sapiens_hsa040200.40558630
86Oxytocin signaling pathway_Homo sapiens_hsa049210.40195703
87Olfactory transduction_Homo sapiens_hsa047400.39446520
88Hedgehog signaling pathway_Homo sapiens_hsa043400.39311537
89TGF-beta signaling pathway_Homo sapiens_hsa043500.39121836
90Collecting duct acid secretion_Homo sapiens_hsa049660.38360523
91ErbB signaling pathway_Homo sapiens_hsa040120.38006926
92Fat digestion and absorption_Homo sapiens_hsa049750.34639866
93Protein export_Homo sapiens_hsa030600.33953822
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33783549
95Renin secretion_Homo sapiens_hsa049240.32934661
96Gastric acid secretion_Homo sapiens_hsa049710.32655020
97DNA replication_Homo sapiens_hsa030300.30874095
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30409020
99RNA polymerase_Homo sapiens_hsa030200.30065476
100Peroxisome_Homo sapiens_hsa041460.29151926

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