SCAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.63535854
2L-phenylalanine catabolic process (GO:0006559)6.63535854
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.42815703
4L-phenylalanine metabolic process (GO:0006558)6.42815703
5aromatic amino acid family catabolic process (GO:0009074)5.83103926
6alpha-linolenic acid metabolic process (GO:0036109)5.71655436
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50789339
8kynurenine metabolic process (GO:0070189)5.38750968
9sulfur amino acid catabolic process (GO:0000098)5.31437974
10negative regulation of fibrinolysis (GO:0051918)5.20324218
11glyoxylate metabolic process (GO:0046487)5.20107045
12indole-containing compound catabolic process (GO:0042436)5.16712648
13indolalkylamine catabolic process (GO:0046218)5.16712648
14tryptophan catabolic process (GO:0006569)5.16712648
15bile acid biosynthetic process (GO:0006699)5.12195630
16urea cycle (GO:0000050)5.10375258
17urea metabolic process (GO:0019627)5.10375258
18cysteine metabolic process (GO:0006534)5.10211139
19high-density lipoprotein particle remodeling (GO:0034375)4.98600938
20tryptophan metabolic process (GO:0006568)4.94145443
21protein carboxylation (GO:0018214)4.89961701
22peptidyl-glutamic acid carboxylation (GO:0017187)4.89961701
23regulation of fibrinolysis (GO:0051917)4.78370651
24serine family amino acid catabolic process (GO:0009071)4.65500185
25regulation of protein activation cascade (GO:2000257)4.62709382
26regulation of cholesterol homeostasis (GO:2000188)4.61698918
27nitrogen cycle metabolic process (GO:0071941)4.57019404
28negative regulation of sterol transport (GO:0032372)4.55119388
29negative regulation of cholesterol transport (GO:0032375)4.55119388
30cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.49433069
31lysine catabolic process (GO:0006554)4.49209583
32lysine metabolic process (GO:0006553)4.49209583
33reverse cholesterol transport (GO:0043691)4.48667864
34complement activation, alternative pathway (GO:0006957)4.45563867
35cellular modified amino acid catabolic process (GO:0042219)4.40709744
36bile acid metabolic process (GO:0008206)4.36337441
37regulation of complement activation (GO:0030449)4.31930375
38negative regulation of erythrocyte differentiation (GO:0045647)4.30614878
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25450293
40dicarboxylic acid biosynthetic process (GO:0043650)4.23856004
41aromatic amino acid family metabolic process (GO:0009072)4.21928109
42proline biosynthetic process (GO:0006561)4.20723048
43homocysteine metabolic process (GO:0050667)4.19406501
44tyrosine metabolic process (GO:0006570)4.15907408
45protein-lipid complex remodeling (GO:0034368)4.11754877
46macromolecular complex remodeling (GO:0034367)4.11754877
47plasma lipoprotein particle remodeling (GO:0034369)4.11754877
48amino-acid betaine metabolic process (GO:0006577)4.11082519
49glutamate metabolic process (GO:0006536)4.10473976
50glycine metabolic process (GO:0006544)4.10470948
51regulation of triglyceride catabolic process (GO:0010896)4.05582672
52coenzyme catabolic process (GO:0009109)4.04406039
53phospholipid efflux (GO:0033700)4.02713988
54alpha-amino acid catabolic process (GO:1901606)4.02578032
55triglyceride homeostasis (GO:0070328)3.98935741
56acylglycerol homeostasis (GO:0055090)3.98935741
57ethanol oxidation (GO:0006069)3.96291913
58regulation of cholesterol esterification (GO:0010872)3.92932580
59plasma lipoprotein particle clearance (GO:0034381)3.90595994
60regulation of fatty acid beta-oxidation (GO:0031998)3.89799176
61cellular ketone body metabolic process (GO:0046950)3.87518263
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.86303222
63glucocorticoid biosynthetic process (GO:0006704)3.83695992
64planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83246606
65serine family amino acid metabolic process (GO:0009069)3.82813294
66cellular amino acid catabolic process (GO:0009063)3.79713841
67COPI coating of Golgi vesicle (GO:0048205)3.74768479
68Golgi transport vesicle coating (GO:0048200)3.74768479
69cholesterol efflux (GO:0033344)3.71250955
70benzene-containing compound metabolic process (GO:0042537)3.70913761
71serine family amino acid biosynthetic process (GO:0009070)3.67019481
72acetyl-CoA metabolic process (GO:0006084)3.65353468
73phospholipid homeostasis (GO:0055091)3.62955090
74fibrinolysis (GO:0042730)3.61068040
75bile acid and bile salt transport (GO:0015721)3.60077009
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.58816041
77positive regulation of lipid catabolic process (GO:0050996)3.58309902
78indolalkylamine metabolic process (GO:0006586)3.56178357
79low-density lipoprotein particle clearance (GO:0034383)3.55118865
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.54294248
81drug catabolic process (GO:0042737)3.52845154
82cellular glucuronidation (GO:0052695)3.52661697
83plasma lipoprotein particle assembly (GO:0034377)3.52648959
842-oxoglutarate metabolic process (GO:0006103)3.51662808
85negative regulation of cell size (GO:0045792)3.49780178
86short-chain fatty acid metabolic process (GO:0046459)3.44431237
873-UTR-mediated mRNA stabilization (GO:0070935)3.42851379
88response to follicle-stimulating hormone (GO:0032354)3.42737681
89adherens junction assembly (GO:0034333)3.42685576
90drug transmembrane transport (GO:0006855)3.41985123
91positive regulation of triglyceride metabolic process (GO:0090208)3.40564514
92protein-lipid complex assembly (GO:0065005)3.40056054
93ketone body metabolic process (GO:1902224)3.36938031
94cholesterol homeostasis (GO:0042632)3.36741221
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.35852526
96sterol homeostasis (GO:0055092)3.35031145
97imidazole-containing compound metabolic process (GO:0052803)3.34789979
98negative regulation of lipase activity (GO:0060192)3.34449021
99protein retention in ER lumen (GO:0006621)3.34386888
100proline metabolic process (GO:0006560)3.32252722
101urate metabolic process (GO:0046415)3.31115354
102epithelial cell differentiation involved in prostate gland development (GO:0060742)3.29716463
103aspartate family amino acid catabolic process (GO:0009068)3.29327497
104positive regulation of triglyceride biosynthetic process (GO:0010867)3.25505663
105valine metabolic process (GO:0006573)3.22257249
106drug metabolic process (GO:0017144)3.20827200
107organic acid catabolic process (GO:0016054)3.20106943
108carboxylic acid catabolic process (GO:0046395)3.20106943
109regulation of plasminogen activation (GO:0010755)3.19513393
110lipoprotein metabolic process (GO:0042157)3.18926109
111complement activation, classical pathway (GO:0006958)3.18455344
112positive regulation of triglyceride lipase activity (GO:0061365)3.17750610
113positive regulation of lipoprotein lipase activity (GO:0051006)3.17750610
114cell-substrate adherens junction assembly (GO:0007045)3.17716297
115focal adhesion assembly (GO:0048041)3.17716297
116arginine metabolic process (GO:0006525)3.16967968
117apoptotic process involved in morphogenesis (GO:0060561)3.16681828
118amine catabolic process (GO:0009310)3.16442320
119cellular biogenic amine catabolic process (GO:0042402)3.16442320
120progesterone metabolic process (GO:0042448)3.16031485
121C21-steroid hormone biosynthetic process (GO:0006700)3.14873605
122linoleic acid metabolic process (GO:0043651)3.14803332
123blood coagulation, intrinsic pathway (GO:0007597)3.13845470
124glucocorticoid metabolic process (GO:0008211)3.13841004
125basement membrane organization (GO:0071711)3.08734817
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06150570
127mannose metabolic process (GO:0006013)3.02264331
128intracellular estrogen receptor signaling pathway (GO:0030520)2.97322675
129regulation of NFAT protein import into nucleus (GO:0051532)2.90996968
130* regulation of cholesterol biosynthetic process (GO:0045540)2.89166877
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88942507
132glutamine family amino acid biosynthetic process (GO:0009084)2.88375632
133diaphragm development (GO:0060539)2.87329207
134pentose-phosphate shunt (GO:0006098)2.87110496
135protein localization to endosome (GO:0036010)2.83308666
136cell-cell junction maintenance (GO:0045217)2.81135541
137C21-steroid hormone metabolic process (GO:0008207)2.81015591
138positive regulation of hormone biosynthetic process (GO:0046886)2.75214309
139cellular protein complex localization (GO:0034629)2.74483806
140embryonic process involved in female pregnancy (GO:0060136)2.72195845
141androgen biosynthetic process (GO:0006702)2.70915465
142glucose catabolic process (GO:0006007)2.70766502
143cell-substrate junction assembly (GO:0007044)2.69935086
144response to laminar fluid shear stress (GO:0034616)2.69882022
145negative regulation of fatty acid transport (GO:2000192)2.68229990
146insulin-like growth factor receptor signaling pathway (GO:0048009)2.68183610
147mRNA stabilization (GO:0048255)2.67783853
148RNA stabilization (GO:0043489)2.67783853
149skeletal muscle organ development (GO:0060538)2.67072326
150activation of Rac GTPase activity (GO:0032863)2.62478660
151* regulation of cholesterol metabolic process (GO:0090181)2.61807678
152regulation of extracellular matrix disassembly (GO:0010715)2.60419452
153cellular response to gonadotropin stimulus (GO:0071371)2.60189209
154maternal placenta development (GO:0001893)2.59701567
155activation of MAPKKK activity (GO:0000185)2.59212266
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.56297484
157NADPH regeneration (GO:0006740)2.54620557
158semaphorin-plexin signaling pathway (GO:0071526)2.54597535
159protein-DNA complex disassembly (GO:0032986)2.52533992
160nucleosome disassembly (GO:0006337)2.52533992
161tricarboxylic acid metabolic process (GO:0072350)2.52164417
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.49491074
163epithelial cell-cell adhesion (GO:0090136)2.47395632
164diacylglycerol metabolic process (GO:0046339)2.47251511
165convergent extension (GO:0060026)2.46297942
166positive regulation of hormone metabolic process (GO:0032352)2.45813225
167regulation of ARF GTPase activity (GO:0032312)2.45745771
168positive regulation of nuclease activity (GO:0032075)2.43718261
169cellular response to epidermal growth factor stimulus (GO:0071364)2.41914937
170retrograde transport, endosome to Golgi (GO:0042147)2.41402770
171very-low-density lipoprotein particle assembly (GO:0034379)2.38508773
172modulation by virus of host morphology or physiology (GO:0019048)2.38137161
173histone H4 deacetylation (GO:0070933)2.37979459
174negative regulation of fatty acid biosynthetic process (GO:0045717)2.36209885
175amyloid precursor protein catabolic process (GO:0042987)2.36025024
176regulation of ARF protein signal transduction (GO:0032012)2.35881736
177regulation of glucose import in response to insulin stimulus (GO:2001273)2.34624542
178peptidyl-tyrosine autophosphorylation (GO:0038083)2.33678692
179regulation of early endosome to late endosome transport (GO:2000641)2.32495990
180atrioventricular valve morphogenesis (GO:0003181)2.31682009
181glucose 6-phosphate metabolic process (GO:0051156)2.30609887
182regulation of cholesterol storage (GO:0010885)2.30216590
183negative regulation of myotube differentiation (GO:0010832)2.30062887
184regulation of chromatin binding (GO:0035561)2.29923314
185negative regulation of granulocyte differentiation (GO:0030853)2.27085244
186modulation by virus of host process (GO:0019054)2.26211877
187protein complex localization (GO:0031503)2.25503019
188pinocytosis (GO:0006907)2.23761062
189protein targeting to plasma membrane (GO:0072661)2.23488849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.21745111
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.63294671
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.79971925
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.16353185
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.01591110
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.89826146
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.80575189
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45134901
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.96558744
10ZNF263_19887448_ChIP-Seq_K562_Human2.30176419
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27114780
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96347848
13CLOCK_20551151_ChIP-Seq_293T_Human1.95347937
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91632131
15LXR_22292898_ChIP-Seq_THP-1_Human1.87906691
16MYC_22102868_ChIP-Seq_BL_Human1.85415352
17* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81262545
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81094751
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.78752553
20* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67953455
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.62855671
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.60835499
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57494663
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54710975
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52227312
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50828028
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48764551
28TCF7_22412390_ChIP-Seq_EML_Mouse1.47830354
29KDM2B_26808549_Chip-Seq_DND41_Human1.44419257
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43604750
31RACK7_27058665_Chip-Seq_MCF-7_Human1.43240475
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42852963
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.41327097
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39100090
35VDR_24763502_ChIP-Seq_THP-1_Human1.38795512
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38586283
37* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36734581
38KDM2B_26808549_Chip-Seq_K562_Human1.36199637
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35554459
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.34992616
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30625503
42MAF_26560356_Chip-Seq_TH1_Human1.29090540
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28765685
44* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27338774
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26965177
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.26349568
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26037135
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.26016667
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23117547
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22468487
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22403305
52CREB1_26743006_Chip-Seq_LNCaP_Human1.21572449
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20739330
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18746265
55* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18529215
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18501847
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17779875
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16016854
59MAF_26560356_Chip-Seq_TH2_Human1.14773290
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14457992
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14159708
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13801389
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13612134
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.12771452
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.12557347
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12295782
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12177809
68E2F7_22180533_ChIP-Seq_HELA_Human1.11809345
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.11043352
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10400064
71TP53_22127205_ChIP-Seq_IMR90_Human1.10040596
72BCL6_27268052_Chip-Seq_Bcells_Human1.09638766
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09550057
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.09282712
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07826702
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07579335
77GATA1_19941826_ChIP-Seq_K562_Human1.07457149
78ETS1_21867929_ChIP-Seq_TH2_Mouse1.06993917
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06791055
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06506542
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03981535
82VDR_21846776_ChIP-Seq_THP-1_Human1.03867608
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01947345
84RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01725182
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01724656
86GATA1_22025678_ChIP-Seq_K562_Human1.01378450
87ATF3_27146783_Chip-Seq_COLON_Human1.01081516
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01027424
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00732598
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00122803
91GATA1_19941827_ChIP-Seq_MEL_Mouse0.99530563
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99374391
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98851576
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.96775671
95* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94963999
96P68_20966046_ChIP-Seq_HELA_Human0.94698265
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93749115
98RUNX1_27514584_Chip-Seq_MCF-7_Human0.93078482
99* GATA6_25053715_ChIP-Seq_YYC3_Human0.91986211
100* ESR1_20079471_ChIP-ChIP_T-47D_Human0.91555533
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.89014544
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88676732
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88502900
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88338922
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87701590
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86041773
107* SMC4_20622854_ChIP-Seq_HELA_Human0.85923413
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84778781
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83924337
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83745882
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82012395
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81965267
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81393763
114UTX_26944678_Chip-Seq_JUKART_Human0.79854384
115CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79556932
116CTCF_21964334_Chip-Seq_Bcells_Human0.79240928
117GATA4_25053715_ChIP-Seq_YYC3_Human0.79195503
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79124885
119* TBX20_22328084_ChIP-Seq_HEART_Mouse0.78850177
120* TBX20_22080862_ChIP-Seq_HEART_Mouse0.78850177
121CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77873832
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77399387
123SCL_19346495_ChIP-Seq_HPC-7_Human0.77093525
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77040305
125SA1_27219007_Chip-Seq_ERYTHROID_Human0.76974299
126BCOR_27268052_Chip-Seq_Bcells_Human0.76785820
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76579104
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76246016
129NCOR1_26117541_ChIP-Seq_K562_Human0.76171651
130* TP63_22573176_ChIP-Seq_HFKS_Human0.75257417
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74966037
132GATA2_19941826_ChIP-Seq_K562_Human0.74518066
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74511825
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.74276962
135CTCF_27219007_Chip-Seq_Bcells_Human0.74066230
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.72936354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.63981607
2MP0005360_urolithiasis6.95741741
3MP0005365_abnormal_bile_salt5.65889849
4MP0005085_abnormal_gallbladder_physiolo5.58417214
5MP0000566_synostosis4.30320347
6MP0008875_abnormal_xenobiotic_pharmacok4.26840400
7MP0003252_abnormal_bile_duct3.80976807
8MP0009840_abnormal_foam_cell3.64114699
9MP0010329_abnormal_lipoprotein_level3.42296663
10MP0005076_abnormal_cell_differentiation3.11794764
11MP0003705_abnormal_hypodermis_morpholog3.09583979
12MP0008260_abnormal_autophagy2.88356554
13MP0005083_abnormal_biliary_tract2.76631228
14MP0003806_abnormal_nucleotide_metabolis2.75385367
15MP0005058_abnormal_lysosome_morphology2.61082565
16MP0003191_abnormal_cellular_cholesterol2.53026716
17MP0003195_calcinosis2.48759617
18MP0001666_abnormal_nutrient_absorption2.43136295
19MP0005332_abnormal_amino_acid2.43076004
20MP0004233_abnormal_muscle_weight2.31789751
21MP0000537_abnormal_urethra_morphology2.24636859
22MP0005409_darkened_coat_color2.21299982
23* MP0000609_abnormal_liver_physiology2.18484617
24MP0003566_abnormal_cell_adhesion2.17579799
25MP0009278_abnormal_bone_marrow2.13337930
26* MP0002118_abnormal_lipid_homeostasis2.02755158
27MP0002249_abnormal_larynx_morphology1.93641744
28MP0008438_abnormal_cutaneous_collagen1.90008503
29MP0000678_abnormal_parathyroid_gland1.86674221
30MP0010234_abnormal_vibrissa_follicle1.82971025
31MP0004019_abnormal_vitamin_homeostasis1.79133953
32MP0003868_abnormal_feces_composition1.76017981
33MP0005451_abnormal_body_composition1.72741826
34MP0003172_abnormal_lysosome_physiology1.64962244
35MP0002396_abnormal_hematopoietic_system1.63995257
36MP0005319_abnormal_enzyme/_coenzyme1.62832375
37MP0003300_gastrointestinal_ulcer1.54514107
38MP0002089_abnormal_postnatal_growth/wei1.52363468
39MP0004272_abnormal_basement_membrane1.46704122
40MP0005584_abnormal_enzyme/coenzyme_acti1.43445642
41MP0002138_abnormal_hepatobiliary_system1.41310364
42MP0002254_reproductive_system_inflammat1.38117839
43MP0000467_abnormal_esophagus_morphology1.34270854
44MP0009780_abnormal_chondrocyte_physiolo1.34130003
45MP0010030_abnormal_orbit_morphology1.32549188
46MP0008961_abnormal_basal_metabolism1.30956431
47MP0009643_abnormal_urine_homeostasis1.27890286
48MP0003011_delayed_dark_adaptation1.27679778
49MP0000604_amyloidosis1.23439950
50MP0000598_abnormal_liver_morphology1.22982344
51MP0003091_abnormal_cell_migration1.21933372
52MP0003115_abnormal_respiratory_system1.20936406
53MP0003329_amyloid_beta_deposits1.18784942
54MP0005647_abnormal_sex_gland1.17630157
55MP0005220_abnormal_exocrine_pancreas1.09749298
56MP0010368_abnormal_lymphatic_system1.07572595
57MP0006138_congestive_heart_failure1.06710663
58MP0000733_abnormal_muscle_development1.06208504
59MP0010630_abnormal_cardiac_muscle1.04490595
60MP0000751_myopathy1.02232585
61MP0003436_decreased_susceptibility_to1.01144274
62MP0003942_abnormal_urinary_system0.97613072
63MP0000858_altered_metastatic_potential0.97272597
64MP0004381_abnormal_hair_follicle0.96829608
65MP0001730_embryonic_growth_arrest0.95414785
66MP0004130_abnormal_muscle_cell0.95032347
67MP0001764_abnormal_homeostasis0.93088855
68MP0001348_abnormal_lacrimal_gland0.91636491
69MP0002078_abnormal_glucose_homeostasis0.89648888
70MP0002796_impaired_skin_barrier0.88029494
71MP0005257_abnormal_intraocular_pressure0.86366727
72MP0000639_abnormal_adrenal_gland0.86127491
73MP0010352_gastrointestinal_tract_polyps0.85912098
74MP0003279_aneurysm0.85863791
75MP0005397_hematopoietic_system_phenotyp0.85564029
76MP0001545_abnormal_hematopoietic_system0.85564029
77MP0000767_abnormal_smooth_muscle0.85038263
78MP0004185_abnormal_adipocyte_glucose0.82900429
79MP0003984_embryonic_growth_retardation0.82366950
80MP0005621_abnormal_cell_physiology0.81029908
81MP0003123_paternal_imprinting0.80880380
82MP0000477_abnormal_intestine_morphology0.80031408
83MP0003656_abnormal_erythrocyte_physiolo0.79892100
84* MP0009642_abnormal_blood_homeostasis0.77863165
85MP0002909_abnormal_adrenal_gland0.76776319
86MP0009763_increased_sensitivity_to0.75812687
87MP0000490_abnormal_crypts_of0.75560496
88MP0003315_abnormal_perineum_morphology0.74754623
89MP0002060_abnormal_skin_morphology0.74654793
90MP0002088_abnormal_embryonic_growth/wei0.74042888
91MP0000579_abnormal_nail_morphology0.73868821
92MP0002086_abnormal_extraembryonic_tissu0.73410585
93MP0005670_abnormal_white_adipose0.73379130
94MP0002132_abnormal_respiratory_system0.72946383
95MP0009384_cardiac_valve_regurgitation0.72826318
96MP0005380_embryogenesis_phenotype0.72577064
97MP0001672_abnormal_embryogenesis/_devel0.72577064
98MP0000534_abnormal_ureter_morphology0.72293311
99MP0003634_abnormal_glial_cell0.71970450
100MP0003763_abnormal_thymus_physiology0.71802486
101MP0005636_abnormal_mineral_homeostasis0.71621030
102MP0003283_abnormal_digestive_organ0.70707284
103MP0001756_abnormal_urination0.70120067
104MP0005334_abnormal_fat_pad0.69951385
105MP0003122_maternal_imprinting0.69919748
106MP0003453_abnormal_keratinocyte_physiol0.69402424
107MP0002822_catalepsy0.68931761
108MP0003183_abnormal_peptide_metabolism0.68476073
109MP0002080_prenatal_lethality0.68471584
110MP0000681_abnormal_thyroid_gland0.68406170
111MP0004264_abnormal_extraembryonic_tissu0.68266273
112MP0005666_abnormal_adipose_tissue0.67928391
113MP0002932_abnormal_joint_morphology0.67568284
114MP0003075_altered_response_to0.66924180
115MP0009672_abnormal_birth_weight0.65897772
116MP0004858_abnormal_nervous_system0.64655996
117MP0002971_abnormal_brown_adipose0.64550993
118MP0002928_abnormal_bile_duct0.63900641
119MP0002092_abnormal_eye_morphology0.63516753
120MP0009931_abnormal_skin_appearance0.63176400
121MP0001849_ear_inflammation0.63043462
122MP0005464_abnormal_platelet_physiology0.62989869
123MP0004808_abnormal_hematopoietic_stem0.62788236
124MP0001958_emphysema0.62551663
125MP0001873_stomach_inflammation0.62162594
126MP0001661_extended_life_span0.59939942
127MP0005408_hypopigmentation0.59491688
128MP0004947_skin_inflammation0.58128642
129MP0005023_abnormal_wound_healing0.56672434
130MP0001915_intracranial_hemorrhage0.56516821
131MP0008874_decreased_physiological_sensi0.55820282
132MP0008469_abnormal_protein_level0.55004819
133MP0002970_abnormal_white_adipose0.53324518
134MP0009765_abnormal_xenobiotic_induced0.52924827
135MP0005375_adipose_tissue_phenotype0.52506529
136MP0002168_other_aberrant_phenotype0.52304011
137MP0003953_abnormal_hormone_level0.52214895
138MP0009053_abnormal_anal_canal0.51512752
139MP0005448_abnormal_energy_balance0.51100878
140MP0000377_abnormal_hair_follicle0.50917127
141MP0001944_abnormal_pancreas_morphology0.49972956
142MP0003303_peritoneal_inflammation0.49762914
143MP0002136_abnormal_kidney_physiology0.49469738
144MP0001243_abnormal_dermal_layer0.49098107
145MP0005248_abnormal_Harderian_gland0.48307793
146MP0001881_abnormal_mammary_gland0.47062183
147MP0001765_abnormal_ion_homeostasis0.46986117
148MP0005535_abnormal_body_temperature0.46867354
149MP0005166_decreased_susceptibility_to0.46725564
150MP0009764_decreased_sensitivity_to0.46518088
151MP0000003_abnormal_adipose_tissue0.46325645
152MP0003690_abnormal_glial_cell0.45768414
153MP0005187_abnormal_penis_morphology0.44067670
154MP0002877_abnormal_melanocyte_morpholog0.43927404
155MP0003699_abnormal_female_reproductive0.43226662
156MP0005395_other_phenotype0.42806208
157MP0005501_abnormal_skin_physiology0.42735184
158MP0000427_abnormal_hair_cycle0.42097446
159MP0005376_homeostasis/metabolism_phenot0.41032744
160MP0003186_abnormal_redox_activity0.40727165

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.32060104
2Intrahepatic cholestasis (HP:0001406)6.28971360
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.19527018
4Xanthomatosis (HP:0000991)5.92834160
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.42908974
6Hypobetalipoproteinemia (HP:0003563)4.92597549
7Prolonged partial thromboplastin time (HP:0003645)4.73963159
8Hyperlipoproteinemia (HP:0010980)4.67166905
9Complement deficiency (HP:0004431)4.40318093
10Abnormality of the common coagulation pathway (HP:0010990)4.01490558
11Ketosis (HP:0001946)4.00661318
12Hypolipoproteinemia (HP:0010981)3.99120170
13Epidermoid cyst (HP:0200040)3.95043174
14Hyperammonemia (HP:0001987)3.90264543
15Hypoalphalipoproteinemia (HP:0003233)3.83090398
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.73082227
17Hyperglycinemia (HP:0002154)3.70811853
18Joint hemorrhage (HP:0005261)3.69612943
19Abnormality of the intrinsic pathway (HP:0010989)3.66860377
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.55484747
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.49004597
22Abnormality of glycine metabolism (HP:0010895)3.38303249
23Abnormality of serine family amino acid metabolism (HP:0010894)3.38303249
24Hyperglycinuria (HP:0003108)3.33798703
25Abnormality of the fingertips (HP:0001211)3.29435275
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.23485494
27Fat malabsorption (HP:0002630)3.22633588
28Abnormality of complement system (HP:0005339)3.13716521
29Hypoglycemic coma (HP:0001325)3.10282872
30Abnormality of methionine metabolism (HP:0010901)3.05514376
31Myocardial infarction (HP:0001658)3.00200270
32Hepatocellular carcinoma (HP:0001402)3.00054965
33Protrusio acetabuli (HP:0003179)2.98880245
34Gout (HP:0001997)2.96955975
35Hypercholesterolemia (HP:0003124)2.90259040
36Flat acetabular roof (HP:0003180)2.89725737
37Skin nodule (HP:0200036)2.88812465
38Ketoacidosis (HP:0001993)2.86919272
39Abnormality of the Achilles tendon (HP:0005109)2.85537343
40Hyperacusis (HP:0010780)2.82139342
41Disproportionate tall stature (HP:0001519)2.80829017
42Ulnar bowing (HP:0003031)2.78583517
43Broad face (HP:0000283)2.75928478
44Spastic diplegia (HP:0001264)2.74036674
45Obstructive sleep apnea (HP:0002870)2.69182614
46Hyperbilirubinemia (HP:0002904)2.67801382
47Shallow orbits (HP:0000586)2.57787592
48Neonatal onset (HP:0003623)2.57148742
49Hypochromic microcytic anemia (HP:0004840)2.53464565
50Mitral stenosis (HP:0001718)2.50788758
51Abnormality of purine metabolism (HP:0004352)2.48475082
52Abnormality of nucleobase metabolism (HP:0010932)2.47137244
53Conjugated hyperbilirubinemia (HP:0002908)2.46822978
54Cerebral aneurysm (HP:0004944)2.44997095
55Abnormality of pyrimidine metabolism (HP:0004353)2.44461567
56Sparse lateral eyebrow (HP:0005338)2.43568970
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43255120
58Delayed CNS myelination (HP:0002188)2.41801560
59Long palpebral fissure (HP:0000637)2.41173975
60Abnormality of the lower motor neuron (HP:0002366)2.41016676
61Bronchomalacia (HP:0002780)2.40722599
62Esophageal varix (HP:0002040)2.32926483
63Lymphangioma (HP:0100764)2.31577097
64Late onset (HP:0003584)2.29721647
65Spontaneous abortion (HP:0005268)2.28755762
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.27112356
67Malnutrition (HP:0004395)2.26874330
68Abnormality of fatty-acid metabolism (HP:0004359)2.25307452
69Cervical subluxation (HP:0003308)2.24417389
70Premature skin wrinkling (HP:0100678)2.24246571
71Achilles tendon contracture (HP:0001771)2.23375370
72Anal stenosis (HP:0002025)2.23227275
73Abnormality of serum amino acid levels (HP:0003112)2.21449705
74Abnormality of the thoracic spine (HP:0100711)2.21058082
75Vertebral compression fractures (HP:0002953)2.20971957
76Steatorrhea (HP:0002570)2.19522726
77Back pain (HP:0003418)2.18004538
78Irritability (HP:0000737)2.16505595
79Advanced eruption of teeth (HP:0006288)2.14895256
80Amyloidosis (HP:0011034)2.13162768
81Biconcave vertebral bodies (HP:0004586)2.12915373
82Increased connective tissue (HP:0009025)2.11972904
83Premature rupture of membranes (HP:0001788)2.11839554
84Hypoglycemic seizures (HP:0002173)2.11751165
85Turricephaly (HP:0000262)2.11179407
86Vascular calcification (HP:0004934)2.11098443
87Acanthocytosis (HP:0001927)2.10762275
88Asymmetry of the thorax (HP:0001555)2.08791169
89Dysmetric saccades (HP:0000641)2.08788692
90Hyperinsulinemic hypoglycemia (HP:0000825)2.07611436
91Thoracic kyphosis (HP:0002942)2.06689691
92Urinary glycosaminoglycan excretion (HP:0003541)2.06489972
93Mucopolysacchariduria (HP:0008155)2.06489972
94Eczematoid dermatitis (HP:0000976)2.06293342
95Abnormal cartilage morphology (HP:0002763)2.06142551
96Blue sclerae (HP:0000592)2.05630184
97Metabolic acidosis (HP:0001942)2.04938446
98Metaphyseal cupping (HP:0003021)2.03590100
99Centrally nucleated skeletal muscle fibers (HP:0003687)2.03251694
100Abnormal gallbladder morphology (HP:0012437)2.02051799
101Self-mutilation (HP:0000742)2.01529741
102Pseudobulbar signs (HP:0002200)2.01386123
103Menorrhagia (HP:0000132)2.00304644
104Abnormal ossification of hand bones (HP:0005921)2.00287864
105Abnormality of carpal bone ossification (HP:0006257)2.00133216
106Cardiovascular calcification (HP:0011915)1.99044267
107Cholelithiasis (HP:0001081)1.98870467
108Gingival bleeding (HP:0000225)1.92566026
109Precocious puberty (HP:0000826)1.91196688
110Abnormality of polysaccharide metabolism (HP:0011012)1.89284867
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89284867
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89284867
113Protuberant abdomen (HP:0001538)1.87851211
114Thin ribs (HP:0000883)1.87430259
115Growth hormone excess (HP:0000845)1.86144731
116Neonatal short-limb short stature (HP:0008921)1.86070861
117Sensorimotor neuropathy (HP:0007141)1.84798445
118Reticulocytosis (HP:0001923)1.84466903
119Neonatal death (HP:0003811)1.83439128
120Germ cell neoplasia (HP:0100728)1.82883305
121Death in childhood (HP:0003819)1.82774290
122Abnormal gallbladder physiology (HP:0012438)1.82266456
123Cholecystitis (HP:0001082)1.82266456
124Global brain atrophy (HP:0002283)1.82265531
125Abnormal enzyme/coenzyme activity (HP:0012379)1.81808906
126Thin bony cortex (HP:0002753)1.81453489
127Lip pit (HP:0100267)1.81117325
128Increased variability in muscle fiber diameter (HP:0003557)1.79925142
129Peritonitis (HP:0002586)1.79578515
130Cellulitis (HP:0100658)1.79308800
131Cerebral inclusion bodies (HP:0100314)1.78436090
132Dysostosis multiplex (HP:0000943)1.78132406
133Natal tooth (HP:0000695)1.77772453
134Stridor (HP:0010307)1.77282683
135Aplasia involving bones of the extremities (HP:0009825)1.77230393
136Aplasia involving bones of the upper limbs (HP:0009823)1.77230393
137Aplasia of the phalanges of the hand (HP:0009802)1.77230393
138Cortical dysplasia (HP:0002539)1.76784744
139Annular pancreas (HP:0001734)1.75711555
140Hemorrhage of the eye (HP:0011885)1.75310259
141Visceral angiomatosis (HP:0100761)1.75277160
142Neurofibrillary tangles (HP:0002185)1.74508597
143Distal lower limb amyotrophy (HP:0008944)1.74467020
144Stroke (HP:0001297)1.74348305
145Hemangiomatosis (HP:0007461)1.74049031
146Status epilepticus (HP:0002133)1.74029307
147Bowel incontinence (HP:0002607)1.73716939
148Limb hypertonia (HP:0002509)1.72496887
149Abnormality of the aortic arch (HP:0012303)1.71581926
150Pointed chin (HP:0000307)1.71539921
151Abnormality of the distal phalanges of the toes (HP:0010182)1.70653829
152Abnormality of endocrine pancreas physiology (HP:0012093)1.69766366
153Abnormality of the pancreatic islet cells (HP:0006476)1.69766366
154Arnold-Chiari malformation (HP:0002308)1.68319629
155Aneurysm (HP:0002617)1.68174316
156Short 5th finger (HP:0009237)1.68038623
157Ureteral stenosis (HP:0000071)1.68027407
158Hyperglycemia (HP:0003074)1.67793629
159Enlarged kidneys (HP:0000105)1.67490247
160Increased mean platelet volume (HP:0011877)1.67172418
161Broad thumb (HP:0011304)1.65855376
162Distal upper limb amyotrophy (HP:0007149)1.65487202
163Upper limb amyotrophy (HP:0009129)1.65487202
164Nephrolithiasis (HP:0000787)1.64369500
165Seborrheic dermatitis (HP:0001051)1.63862491
166Elevated alkaline phosphatase (HP:0003155)1.63773128
167Broad distal phalanx of finger (HP:0009836)1.63693179
168Mitral valve prolapse (HP:0001634)1.62631155
169Mitral regurgitation (HP:0001653)1.62473029
170Broad palm (HP:0001169)1.62454086
171Poikilocytosis (HP:0004447)1.61870408
172Thrombophlebitis (HP:0004418)1.61566059
173Dislocated radial head (HP:0003083)1.61433060
174Ankyloglossia (HP:0010296)1.61347570
175Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61166124
176Polycythemia (HP:0001901)1.61070414
177Abnormal vertebral ossification (HP:0100569)1.60695422
178Polygenic inheritance (HP:0010982)1.59524303
179Hypertriglyceridemia (HP:0002155)1.58339471
180Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57738094
181Arachnodactyly (HP:0001166)1.56779745
182Gastrointestinal dysmotility (HP:0002579)1.56441769
183Hand muscle atrophy (HP:0009130)1.54811637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.01174706
2ERN14.29870467
3EEF2K3.44064497
4MAP3K103.43139134
5SIK13.37740369
6PKN23.33995158
7PRPF4B3.25957603
8SMG13.21118334
9FGFR42.67049782
10BCKDK2.65949449
11TAOK32.08596778
12LATS11.98594887
13RIPK11.91229805
14CDK121.85002588
15PTK61.78991703
16MAP3K71.61930462
17TAOK11.61721989
18MAP2K31.58057353
19TYRO31.49246415
20TESK21.46730419
21FGFR21.42461141
22KSR21.38678215
23GRK61.37096221
24LATS21.31974004
25IRAK31.31285742
26CAMK1D1.30968812
27ICK1.27757481
28ERBB41.23524841
29CAMK1G1.23366830
30PDGFRA1.17163254
31EPHA21.16452144
32EPHB11.13051812
33SCYL21.11362058
34MAPK111.09812398
35PRKD31.09549239
36MTOR1.07113034
37RET1.06822412
38MAP2K41.06734933
39MAP3K21.04219332
40TAOK21.04155492
41RPS6KC11.03194230
42RPS6KL11.03194230
43TNK21.03085026
44PAK61.01148978
45MAP4K10.97112977
46SIK20.96697162
47STK240.95069312
48MAP3K90.94589735
49DAPK20.93013279
50JAK20.88220107
51PRKCH0.87215353
52CDC42BPA0.86199078
53LRRK20.85821268
54LMTK20.85277479
55MAP3K130.84872172
56PAK40.83849071
57PTK20.83307962
58BMX0.80629382
59FRK0.79148623
60RPS6KA60.77897666
61MAP3K60.77187916
62CDK70.76465112
63FGFR30.76287320
64MAP3K30.75985351
65MAP3K10.75346486
66TYK20.73996217
67NTRK10.70269402
68RIPK40.70077163
69CAMKK10.68277338
70ALK0.67909525
71CDK60.67751596
72MOS0.66976665
73MST1R0.66121336
74JAK10.65434898
75PAK30.64609072
76HIPK20.64491136
77MARK20.64354633
78PAK20.62368462
79SGK30.61363249
80CDK40.60725782
81WNK10.60466640
82MAPK120.59867444
83DYRK1B0.57557976
84PDK10.56032137
85ARAF0.55677323
86GSK3A0.54952543
87PDPK10.53681606
88TESK10.53521443
89PRKD10.53116202
90ILK0.52824514
91ERBB20.51899819
92PRKAA20.51630780
93PRKAA10.51261473
94STK30.49751367
95MAP2K20.49061633
96INSRR0.48628352
97CDK90.47867454
98MAP3K80.47652453
99MAPK40.47532803
100ZAP700.47471496
101STK380.46846730
102FLT30.46246980
103HCK0.45705857
104EPHA40.45279636
105CCNB10.45203236
106KDR0.44279295
107IRAK40.43595318
108PRKG20.43216365
109IRAK20.43091557
110PRKCZ0.42529805
111RPS6KA20.42516970
112CSF1R0.42441647
113TTN0.42246436
114PRKD20.42110280
115EPHA30.41975102
116STK100.41507056
117STK110.40387554
118CAMK40.40261868
119AKT20.39198121
120NME20.37044924
121MAP2K10.36426459
122RPS6KB20.35078195
123RAF10.33997567
124MAPK100.33717676
125NEK60.33481717
126RPS6KA10.33325178
127BRD40.32825201
128CHUK0.32818093
129FES0.32632638
130FER0.32469080
131MAP3K40.32273082
132CAMK10.32237434
133TGFBR20.31786588
134PIM20.31736570
135JAK30.31533213
136FGFR10.31531748
137PDGFRB0.31477086
138PRKACG0.31021469
139MAPKAPK30.30451370
140MAPK70.30447517
141MAP3K110.29911244

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.25037848
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.17936288
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45268367
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43394936
5Arginine biosynthesis_Homo sapiens_hsa002203.06039375
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67242334
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53344020
8Tryptophan metabolism_Homo sapiens_hsa003802.51023311
9Complement and coagulation cascades_Homo sapiens_hsa046102.49996192
10Fatty acid degradation_Homo sapiens_hsa000712.43835487
11Other glycan degradation_Homo sapiens_hsa005112.32777826
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27016758
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18642682
14Butanoate metabolism_Homo sapiens_hsa006502.03022367
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93900014
16Notch signaling pathway_Homo sapiens_hsa043301.93391669
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89168470
18PPAR signaling pathway_Homo sapiens_hsa033201.87945800
19Fatty acid metabolism_Homo sapiens_hsa012121.84936122
20Bile secretion_Homo sapiens_hsa049761.84077622
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78059497
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71743015
23Caffeine metabolism_Homo sapiens_hsa002321.71084749
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.65650193
25Peroxisome_Homo sapiens_hsa041461.64463429
26Propanoate metabolism_Homo sapiens_hsa006401.63334869
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60158194
28Selenocompound metabolism_Homo sapiens_hsa004501.60129689
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55651804
30Chemical carcinogenesis_Homo sapiens_hsa052041.54790129
31Histidine metabolism_Homo sapiens_hsa003401.54007999
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.52841533
33beta-Alanine metabolism_Homo sapiens_hsa004101.50344803
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48842599
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.40198405
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35356623
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.33423274
38Staphylococcus aureus infection_Homo sapiens_hsa051501.31370338
39Lysine degradation_Homo sapiens_hsa003101.28815129
40VEGF signaling pathway_Homo sapiens_hsa043701.27427114
41Retinol metabolism_Homo sapiens_hsa008301.24910735
42Pyruvate metabolism_Homo sapiens_hsa006201.23871260
43Thyroid cancer_Homo sapiens_hsa052161.22469642
44ABC transporters_Homo sapiens_hsa020101.20012171
45Fructose and mannose metabolism_Homo sapiens_hsa000511.18881986
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17977228
47Phenylalanine metabolism_Homo sapiens_hsa003601.15239952
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.14167295
49Biosynthesis of amino acids_Homo sapiens_hsa012301.13973133
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13358615
51Fat digestion and absorption_Homo sapiens_hsa049751.11850863
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.11444217
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11013474
54Starch and sucrose metabolism_Homo sapiens_hsa005001.10836090
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09983710
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09391754
57Inositol phosphate metabolism_Homo sapiens_hsa005621.09368033
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.07260844
59Tyrosine metabolism_Homo sapiens_hsa003501.02761955
60ErbB signaling pathway_Homo sapiens_hsa040121.01204510
61Sulfur metabolism_Homo sapiens_hsa009201.00520161
62Sulfur relay system_Homo sapiens_hsa041220.99112807
63Choline metabolism in cancer_Homo sapiens_hsa052310.96011931
64Carbon metabolism_Homo sapiens_hsa012000.93781465
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93729810
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.92516454
67B cell receptor signaling pathway_Homo sapiens_hsa046620.89884917
68Folate biosynthesis_Homo sapiens_hsa007900.89513207
69Fatty acid biosynthesis_Homo sapiens_hsa000610.88546106
70Focal adhesion_Homo sapiens_hsa045100.86752869
71Renal cell carcinoma_Homo sapiens_hsa052110.84576014
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84383011
73GnRH signaling pathway_Homo sapiens_hsa049120.80295296
74Steroid biosynthesis_Homo sapiens_hsa001000.80123157
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78931615
76Adherens junction_Homo sapiens_hsa045200.78746683
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78158214
78Colorectal cancer_Homo sapiens_hsa052100.76532550
79Fatty acid elongation_Homo sapiens_hsa000620.76138721
80Glycerolipid metabolism_Homo sapiens_hsa005610.76047926
81N-Glycan biosynthesis_Homo sapiens_hsa005100.74871668
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.74466071
83ECM-receptor interaction_Homo sapiens_hsa045120.74249902
84Arginine and proline metabolism_Homo sapiens_hsa003300.72600265
85Small cell lung cancer_Homo sapiens_hsa052220.71855205
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69578280
87Hepatitis C_Homo sapiens_hsa051600.69377432
88Vitamin B6 metabolism_Homo sapiens_hsa007500.68729560
89Endocytosis_Homo sapiens_hsa041440.68577228
90Amoebiasis_Homo sapiens_hsa051460.68453668
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.68343604
92Insulin resistance_Homo sapiens_hsa049310.68088771
93Prostate cancer_Homo sapiens_hsa052150.67651998
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67587197
95Vitamin digestion and absorption_Homo sapiens_hsa049770.67334726
96Proteoglycans in cancer_Homo sapiens_hsa052050.62486765
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59227746
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.59072964
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57351237
100HIF-1 signaling pathway_Homo sapiens_hsa040660.55144083
101One carbon pool by folate_Homo sapiens_hsa006700.54781968
102MicroRNAs in cancer_Homo sapiens_hsa052060.51519665
103Hepatitis B_Homo sapiens_hsa051610.50525175
104Melanogenesis_Homo sapiens_hsa049160.48082775
105Osteoclast differentiation_Homo sapiens_hsa043800.47417623
106Renin-angiotensin system_Homo sapiens_hsa046140.45038173
107Prion diseases_Homo sapiens_hsa050200.44797806
108Glucagon signaling pathway_Homo sapiens_hsa049220.44352114
109Ovarian steroidogenesis_Homo sapiens_hsa049130.43209106
110AMPK signaling pathway_Homo sapiens_hsa041520.36639541
111Pentose phosphate pathway_Homo sapiens_hsa000300.36088731
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35764528
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35550709
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29053498
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.28440770
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28326304
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27841519
118mTOR signaling pathway_Homo sapiens_hsa041500.26683230
119Glutathione metabolism_Homo sapiens_hsa004800.26523371
120Non-small cell lung cancer_Homo sapiens_hsa052230.25690160
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.24379602
122Insulin signaling pathway_Homo sapiens_hsa049100.24062786
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22925991
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21111188
125Bladder cancer_Homo sapiens_hsa052190.18443542
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18398878
127Glioma_Homo sapiens_hsa052140.17710009
128Chronic myeloid leukemia_Homo sapiens_hsa052200.17263106
129Galactose metabolism_Homo sapiens_hsa000520.16480002
130Prolactin signaling pathway_Homo sapiens_hsa049170.15078072
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14655958
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13987237
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13665454
134Metabolic pathways_Homo sapiens_hsa011000.13201104
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12013307
136Thyroid hormone synthesis_Homo sapiens_hsa049180.10505784
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09552903
138Pancreatic cancer_Homo sapiens_hsa052120.08776737
139Type II diabetes mellitus_Homo sapiens_hsa049300.08439866
140Acute myeloid leukemia_Homo sapiens_hsa052210.07034512
141Endometrial cancer_Homo sapiens_hsa052130.05502424
142Estrogen signaling pathway_Homo sapiens_hsa049150.04731241
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.04424741

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