SCARA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.13836028
2collagen fibril organization (GO:0030199)5.56358315
3keratan sulfate catabolic process (GO:0042340)4.88825869
4regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.69931963
5regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.39368800
6glomerular basement membrane development (GO:0032836)4.37276778
7NADH metabolic process (GO:0006734)4.25033154
8collagen metabolic process (GO:0032963)4.20800577
9muscle filament sliding (GO:0030049)4.14491833
10actin-myosin filament sliding (GO:0033275)4.14491833
11gonadal mesoderm development (GO:0007506)4.13978781
12collagen catabolic process (GO:0030574)4.13677176
13apoptotic cell clearance (GO:0043277)4.04421945
14multicellular organismal macromolecule metabolic process (GO:0044259)4.03344164
15triglyceride catabolic process (GO:0019433)4.02628825
16retina vasculature morphogenesis in camera-type eye (GO:0061299)4.00820356
17basement membrane organization (GO:0071711)3.98531210
18muscle hypertrophy (GO:0014896)3.98523908
19extracellular matrix assembly (GO:0085029)3.86787626
20complement activation, alternative pathway (GO:0006957)3.86747027
21multicellular organismal metabolic process (GO:0044236)3.85841276
22multicellular organismal catabolic process (GO:0044243)3.83687582
23positive regulation of fatty acid beta-oxidation (GO:0032000)3.83285538
24chondrocyte proliferation (GO:0035988)3.81617542
25barbed-end actin filament capping (GO:0051016)3.81360706
26negative regulation of gluconeogenesis (GO:0045721)3.75902987
27skin morphogenesis (GO:0043589)3.75785397
28cGMP-mediated signaling (GO:0019934)3.74190821
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.73174176
30negative regulation of protein activation cascade (GO:2000258)3.69004824
31regulation of complement activation (GO:0030449)3.66395214
32negative regulation of complement activation (GO:0045916)3.65617464
33positive regulation of fatty acid oxidation (GO:0046321)3.64361591
34peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.61323897
35opsonization (GO:0008228)3.60458567
36negative regulation of cardiac muscle hypertrophy (GO:0010614)3.60080101
37extracellular matrix disassembly (GO:0022617)3.59903102
38anatomical structure regression (GO:0060033)3.59494653
39regulation of protein activation cascade (GO:2000257)3.57003703
40endodermal cell differentiation (GO:0035987)3.56526615
41bone trabecula formation (GO:0060346)3.54349508
42myofibril assembly (GO:0030239)3.54224590
43low-density lipoprotein particle clearance (GO:0034383)3.53080951
44sarcomere organization (GO:0045214)3.52171086
45actin-mediated cell contraction (GO:0070252)3.49803004
46acylglycerol catabolic process (GO:0046464)3.49734912
47neutral lipid catabolic process (GO:0046461)3.49734912
48metanephric mesenchyme development (GO:0072075)3.45459424
49sequestering of extracellular ligand from receptor (GO:0035581)3.44190994
50kidney mesenchyme development (GO:0072074)3.43574382
51epoxygenase P450 pathway (GO:0019373)3.38482338
52positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.37838364
53positive regulation of extracellular matrix organization (GO:1903055)3.36021607
54cellular response to epinephrine stimulus (GO:0071872)3.35082536
55negative regulation of muscle hypertrophy (GO:0014741)3.30624589
56extracellular fibril organization (GO:0043206)3.28120432
57cell migration involved in heart development (GO:0060973)3.26460810
58negative regulation of chondrocyte differentiation (GO:0032331)3.25037063
59regulation of sequestering of triglyceride (GO:0010889)3.24748962
60ethanol oxidation (GO:0006069)3.23543234
61regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.20855215
62regulation of fatty acid beta-oxidation (GO:0031998)3.17891010
63endothelial cell morphogenesis (GO:0001886)3.11684444
64transcytosis (GO:0045056)3.10925531
65outer ear morphogenesis (GO:0042473)3.08480020
66positive regulation of glycolytic process (GO:0045821)3.08219785
67regulation of cardiac muscle hypertrophy (GO:0010611)3.07882087
68striated muscle hypertrophy (GO:0014897)3.06716850
69blood vessel maturation (GO:0001955)3.06706226
70negative regulation of heart growth (GO:0061117)3.06168357
71negative regulation of cardiac muscle tissue growth (GO:0055022)3.06168357
72dermatan sulfate biosynthetic process (GO:0030208)3.04351098
73lung lobe morphogenesis (GO:0060463)3.01047747
74sarcoplasmic reticulum calcium ion transport (GO:0070296)2.99258090
75regulation of muscle hypertrophy (GO:0014743)2.98905898
76alpha-linolenic acid metabolic process (GO:0036109)2.98369421
77epithelial cell-cell adhesion (GO:0090136)2.97493659
78glomerular filtration (GO:0003094)2.96648556
79endothelium development (GO:0003158)2.96570572
80regulation of relaxation of muscle (GO:1901077)2.95835876
81negative regulation of cartilage development (GO:0061037)2.94830057
82cardiac muscle hypertrophy (GO:0003300)2.94251258
83valine metabolic process (GO:0006573)2.94110194
84positive regulation of endothelial cell apoptotic process (GO:2000353)2.93507322
85response to epinephrine (GO:0071871)2.93200469
86fibril organization (GO:0097435)2.93070174
87negative regulation of granulocyte differentiation (GO:0030853)2.92582510
88creatine metabolic process (GO:0006600)2.88680826
89cardiac muscle contraction (GO:0060048)2.88456219
90ovulation from ovarian follicle (GO:0001542)2.87121286
91negative regulation of smooth muscle cell proliferation (GO:0048662)2.87109992
92regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85614702
93positive regulation of glucose import (GO:0046326)2.84536481
94hemidesmosome assembly (GO:0031581)2.83817821
95diacylglycerol metabolic process (GO:0046339)2.83738059
96regulation of fatty acid oxidation (GO:0046320)2.83329146
97positive regulation of glycogen biosynthetic process (GO:0045725)2.81863924
98actomyosin structure organization (GO:0031032)2.81191542
99positive regulation of male gonad development (GO:2000020)2.80827802
100middle ear morphogenesis (GO:0042474)2.80232261
101regulation of plasminogen activation (GO:0010755)2.79863357
102endocrine hormone secretion (GO:0060986)2.79464437
103lung vasculature development (GO:0060426)2.79445123
104extracellular matrix organization (GO:0030198)2.78617316
105regulation of muscle adaptation (GO:0043502)2.78569044
106positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.78533667
107extracellular structure organization (GO:0043062)2.78424989
108dermatan sulfate metabolic process (GO:0030205)2.78225102
109cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.77303207
110detection of molecule of bacterial origin (GO:0032490)2.77109049
111receptor guanylyl cyclase signaling pathway (GO:0007168)2.76527352
112surfactant homeostasis (GO:0043129)2.74778019
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.74747285
114growth hormone receptor signaling pathway (GO:0060396)2.74088859
115vitamin A metabolic process (GO:0006776)2.73879611
116white fat cell differentiation (GO:0050872)2.69776902
117skeletal muscle contraction (GO:0003009)2.69352134
118plasma membrane repair (GO:0001778)2.68873218
119peripheral nervous system axon ensheathment (GO:0032292)2.67845009
120myelination in peripheral nervous system (GO:0022011)2.67845009
121heart trabecula formation (GO:0060347)2.67433529
122actin filament-based movement (GO:0030048)2.66636691
123sulfur compound catabolic process (GO:0044273)2.66382604
124striated muscle contraction (GO:0006941)2.66081561
125fatty acid transmembrane transport (GO:1902001)2.65341982
126prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.65059862
127renal filtration (GO:0097205)2.64904084
128iron ion import (GO:0097286)2.63697441
129vascular endothelial growth factor signaling pathway (GO:0038084)2.62654751
130negative regulation of cardiac muscle tissue development (GO:0055026)2.62172885
131regulation of cholesterol storage (GO:0010885)2.62155571
132regulation of gonadotropin secretion (GO:0032276)2.60973710
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60242944
134axon extension involved in axon guidance (GO:0048846)2.60229456
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.60229456
136carnitine shuttle (GO:0006853)2.59373750
137protein localization to cell surface (GO:0034394)2.58822695
138positive regulation of mesenchymal cell proliferation (GO:0002053)2.58679942
139positive regulation of glycogen metabolic process (GO:0070875)2.58228199
140cGMP biosynthetic process (GO:0006182)2.56905238
141regulation of cell communication by electrical coupling (GO:0010649)2.56772154
142positive regulation of lipid storage (GO:0010884)2.55620689
143cardiac muscle hypertrophy in response to stress (GO:0014898)2.55280495
144muscle hypertrophy in response to stress (GO:0003299)2.55280495
145cardiac muscle adaptation (GO:0014887)2.55280495
146negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.55156665
147positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.55005030
148primary alcohol metabolic process (GO:0034308)2.54907632
149angiogenesis involved in wound healing (GO:0060055)2.53896899
150positive regulation of macrophage cytokine production (GO:0060907)2.53841170
151sex determination (GO:0007530)2.53765536
152striated muscle adaptation (GO:0014888)2.53133490
153brown fat cell differentiation (GO:0050873)2.52871233
154cardiac muscle tissue morphogenesis (GO:0055008)2.52687068
155ethanol metabolic process (GO:0006067)2.52660537
156embryonic cranial skeleton morphogenesis (GO:0048701)2.52417925
157protein carboxylation (GO:0018214)2.52138734
158peptidyl-glutamic acid carboxylation (GO:0017187)2.52138734
159regulation of skeletal muscle contraction (GO:0014819)2.51810126
160glial cell migration (GO:0008347)2.51316508
161positive regulation of fatty acid metabolic process (GO:0045923)2.51225345
162regulation of phospholipase A2 activity (GO:0032429)2.50755807
163protein-chromophore linkage (GO:0018298)2.50552773
164skeletal muscle adaptation (GO:0043501)2.50137208
165positive regulation of glucose transport (GO:0010828)2.47891117
166regulation of actin filament-based movement (GO:1903115)2.47558668
167biotin metabolic process (GO:0006768)2.46262762
168regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.45925889
169muscle tissue morphogenesis (GO:0060415)2.45713923
170cardiac myofibril assembly (GO:0055003)2.44450218
171mesenchymal-epithelial cell signaling (GO:0060638)2.44399003
172regulation of cardiac muscle cell differentiation (GO:2000725)2.43816902
173myotube cell development (GO:0014904)2.43646326
174regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.42348700
175muscle contraction (GO:0006936)2.42172468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.02807093
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.82458267
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.82186328
4CLOCK_20551151_ChIP-Seq_293T_Human3.71557020
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.52025498
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.31052567
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.76384183
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.69458732
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.64458790
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.63004491
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.60424461
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.55324259
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.49794709
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.39930886
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.39690645
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22327537
17* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.10551616
18* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.09390870
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.08278260
20* CJUN_26792858_Chip-Seq_BT549_Human2.03293314
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.92320745
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91476086
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.87028188
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86893744
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78018328
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73660180
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66701011
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65247930
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65247930
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60690030
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.58686842
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.58686842
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56646969
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55298156
35* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50215763
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46975120
37* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45883980
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44249179
39EZH2_22144423_ChIP-Seq_EOC_Human1.43526468
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.43136542
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37209116
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36831896
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34755244
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34665924
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33543195
46PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.32071074
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31743235
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31681176
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.30392410
50BRD4_25478319_ChIP-Seq_HGPS_Human1.27021420
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24351336
52DROSHA_22980978_ChIP-Seq_HELA_Human1.23935098
53ZNF263_19887448_ChIP-Seq_K562_Human1.22228636
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.20850933
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19239948
56* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18436493
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.17858583
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.16858359
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12825405
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11765944
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09391747
62GATA1_22025678_ChIP-Seq_K562_Human1.09096935
63RACK7_27058665_Chip-Seq_MCF-7_Human1.08819283
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08075195
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.07952943
66* FOXA2_19822575_ChIP-Seq_HepG2_Human1.07926811
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.07521779
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07223669
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06986220
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05671184
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05391737
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.05272490
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05222195
74* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.04942106
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04578336
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.03459043
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03037152
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02967615
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.02102741
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01767866
81RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01767866
82AHR_22903824_ChIP-Seq_MCF-7_Human1.01505763
83SA1_22415368_ChIP-Seq_MEFs_Mouse1.01463710
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00752346
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00752346
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00583260
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.00387586
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99825347
89SOX2_20726797_ChIP-Seq_SW620_Human0.99746178
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98674429
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97854307
92SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97719406
93ISL1_27105846_Chip-Seq_CPCs_Mouse0.97235305
94BCAT_22108803_ChIP-Seq_LS180_Human0.97048130
95KDM2B_26808549_Chip-Seq_K562_Human0.95736470
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95086643
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92613324
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92589170
99MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92001857
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91784713
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90753413
102CTCF_27219007_Chip-Seq_Bcells_Human0.90192101
103TP53_20018659_ChIP-ChIP_R1E_Mouse0.89890904
104LXR_22292898_ChIP-Seq_THP-1_Human0.89165284
105* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89072644
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.88622407
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88615450
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.88545014
109SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88389545
110TP53_16413492_ChIP-PET_HCT116_Human0.87892143
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86921140
112* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85918410
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85518992
114* SMC4_20622854_ChIP-Seq_HELA_Human0.85005023
115AR_21572438_ChIP-Seq_LNCaP_Human0.83343987
116ATF3_27146783_Chip-Seq_COLON_Human0.83341724
117EED_16625203_ChIP-ChIP_MESCs_Mouse0.83092055
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82952408
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82167960
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.81981514
121* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81305003
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80284949
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79804763
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.79782104
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79323615
126TP53_22127205_ChIP-Seq_IMR90_Human0.77830781
127KLF5_25053715_ChIP-Seq_YYC3_Human0.77811925
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77518224
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76936349
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76824291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.41618397
2MP0005275_abnormal_skin_tensile6.14942137
3MP0005503_abnormal_tendon_morphology5.42926890
4MP0003705_abnormal_hypodermis_morpholog4.12461613
5MP0003011_delayed_dark_adaptation3.52833389
6MP0001958_emphysema3.49511826
7MP0004272_abnormal_basement_membrane2.75722254
8MP0003279_aneurysm2.69849225
9MP0000751_myopathy2.51450200
10MP0009384_cardiac_valve_regurgitation2.38693275
11MP0003646_muscle_fatigue2.38448193
12MP0002060_abnormal_skin_morphology2.23045228
13MP0002108_abnormal_muscle_morphology2.17211685
14MP0005670_abnormal_white_adipose2.16098866
15MP0002837_dystrophic_cardiac_calcinosis2.14778890
16MP0006054_spinal_hemorrhage1.84500946
17MP0005508_abnormal_skeleton_morphology1.70793125
18MP0004215_abnormal_myocardial_fiber1.69806010
19MP0003828_pulmonary_edema1.68903705
20MP0002295_abnormal_pulmonary_circulatio1.64076635
21MP0003045_fibrosis1.55802714
22MP0000747_muscle_weakness1.54056762
23MP0005666_abnormal_adipose_tissue1.52372547
24MP0004130_abnormal_muscle_cell1.51303929
25MP0005257_abnormal_intraocular_pressure1.49249968
26MP0002972_abnormal_cardiac_muscle1.47078490
27MP0001661_extended_life_span1.44410420
28MP0004185_abnormal_adipocyte_glucose1.41375394
29MP0002168_other_aberrant_phenotype1.40333603
30MP0004145_abnormal_muscle_electrophysio1.37695747
31MP0003950_abnormal_plasma_membrane1.37480199
32MP0004484_altered_response_of1.32613637
33MP0004084_abnormal_cardiac_muscle1.32238078
34MP0005623_abnormal_meninges_morphology1.23565548
35MP0005375_adipose_tissue_phenotype1.23320512
36MP0003566_abnormal_cell_adhesion1.23072396
37MP0002896_abnormal_bone_mineralization1.19910333
38MP0005023_abnormal_wound_healing1.18023262
39MP0000013_abnormal_adipose_tissue1.14791080
40MP0003252_abnormal_bile_duct1.14602279
41MP0002254_reproductive_system_inflammat1.12615865
42MP0000750_abnormal_muscle_regeneration1.11900053
43MP0002282_abnormal_trachea_morphology1.10153767
44MP0002249_abnormal_larynx_morphology1.07489608
45MP0002269_muscular_atrophy1.06949962
46MP0001243_abnormal_dermal_layer1.06129344
47MP0004036_abnormal_muscle_relaxation1.04990561
48MP0000003_abnormal_adipose_tissue1.01895178
49MP0005171_absent_coat_pigmentation1.01762731
50MP0004134_abnormal_chest_morphology1.01010215
51MP0008995_early_reproductive_senescence1.00611602
52MP0000733_abnormal_muscle_development1.00586386
53MP0010386_abnormal_urinary_bladder0.99589101
54MP0002876_abnormal_thyroid_physiology0.99551511
55MP0005390_skeleton_phenotype0.99043245
56MP0003091_abnormal_cell_migration0.99038406
57MP0004087_abnormal_muscle_fiber0.98820446
58MP0000163_abnormal_cartilage_morphology0.98485132
59MP0005330_cardiomyopathy0.97407481
60MP0010368_abnormal_lymphatic_system0.96835136
61MP0005167_abnormal_blood-brain_barrier0.96629856
62MP0002933_joint_inflammation0.95431649
63MP0000230_abnormal_systemic_arterial0.93518548
64MP0006138_congestive_heart_failure0.93480536
65MP0002970_abnormal_white_adipose0.92808018
66MP0005165_increased_susceptibility_to0.90454362
67MP0005377_hearing/vestibular/ear_phenot0.90253285
68MP0003878_abnormal_ear_physiology0.90253285
69MP0005369_muscle_phenotype0.90081825
70MP0000767_abnormal_smooth_muscle0.89685465
71MP0003959_abnormal_lean_body0.89539077
72MP0005076_abnormal_cell_differentiation0.89351938
73MP0003115_abnormal_respiratory_system0.88117619
74MP0002115_abnormal_skeleton_extremities0.87271957
75MP0002127_abnormal_cardiovascular_syste0.87211135
76MP0001542_abnormal_bone_strength0.85347299
77MP0002139_abnormal_hepatobiliary_system0.84452033
78MP0005334_abnormal_fat_pad0.84315365
79MP0003191_abnormal_cellular_cholesterol0.83933601
80MP0010329_abnormal_lipoprotein_level0.83823233
81MP0000759_abnormal_skeletal_muscle0.83034116
82MP0009379_abnormal_foot_pigmentation0.82778814
83MP0000749_muscle_degeneration0.81591520
84MP0001533_abnormal_skeleton_physiology0.81369571
85MP0000534_abnormal_ureter_morphology0.81137579
86MP0002998_abnormal_bone_remodeling0.80558537
87MP0005409_darkened_coat_color0.80115218
88MP0000249_abnormal_blood_vessel0.79593397
89MP0003195_calcinosis0.78903002
90MP0003385_abnormal_body_wall0.78808927
91MP0003137_abnormal_impulse_conducting0.78445761
92MP0003300_gastrointestinal_ulcer0.77868162
93MP0004233_abnormal_muscle_weight0.77179463
94MP0004858_abnormal_nervous_system0.76856997
95MP0000428_abnormal_craniofacial_morphol0.76102037
96MP0009250_abnormal_appendicular_skeleto0.74947612
97MP0005535_abnormal_body_temperature0.74375642
98MP0002971_abnormal_brown_adipose0.73539981
99MP0003724_increased_susceptibility_to0.72678659
100MP0000579_abnormal_nail_morphology0.72523607
101MP0000343_altered_response_to0.69866337
102MP0002128_abnormal_blood_circulation0.69594911
103MP0004019_abnormal_vitamin_homeostasis0.69340488
104MP0001544_abnormal_cardiovascular_syste0.69305050
105MP0005385_cardiovascular_system_phenoty0.69305050
106MP0002133_abnormal_respiratory_system0.69273995
107MP0005388_respiratory_system_phenotype0.69273995
108MP0005620_abnormal_muscle_contractility0.69213581
109MP0004085_abnormal_heartbeat0.69169684
110MP0005164_abnormal_response_to0.69059507
111MP0008004_abnormal_stomach_pH0.68190458
112MP0005595_abnormal_vascular_smooth0.68177661
113MP0002332_abnormal_exercise_endurance0.68074494
114MP0003942_abnormal_urinary_system0.67823526
115MP0003283_abnormal_digestive_organ0.67198152
116MP0003868_abnormal_feces_composition0.66667469
117MP0005647_abnormal_sex_gland0.66356307
118MP0001879_abnormal_lymphatic_vessel0.66194278
119MP0002106_abnormal_muscle_physiology0.65701516
120MP0009780_abnormal_chondrocyte_physiolo0.63876421
121MP0008775_abnormal_heart_ventricle0.63739526
122MP0009115_abnormal_fat_cell0.63334889
123MP0010630_abnormal_cardiac_muscle0.63224106
124MP0004883_abnormal_blood_vessel0.62634343
125MP0002796_impaired_skin_barrier0.60826770
126MP0003879_abnormal_hair_cell0.60463153
127MP0009278_abnormal_bone_marrow0.60102942
128MP0005248_abnormal_Harderian_gland0.60052290
129MP0001849_ear_inflammation0.59907443
130MP0002166_altered_tumor_susceptibility0.57258780
131MP0001299_abnormal_eye_distance/0.56728853
132MP0002009_preneoplasia0.56130052
133MP0002118_abnormal_lipid_homeostasis0.55522048
134MP0004782_abnormal_surfactant_physiolog0.54807789

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.45926994
2Ankle contracture (HP:0006466)6.96222047
3Premature rupture of membranes (HP:0001788)5.67899995
4Broad metatarsal (HP:0001783)5.52386091
5Type 1 muscle fiber predominance (HP:0003803)5.52318549
6Follicular hyperkeratosis (HP:0007502)5.15393854
7Aortic aneurysm (HP:0004942)4.92728278
8Aortic dissection (HP:0002647)4.88051985
9Increased connective tissue (HP:0009025)4.75035257
10Wrist flexion contracture (HP:0001239)4.30959503
11Muscle fiber inclusion bodies (HP:0100299)4.18108406
12Nemaline bodies (HP:0003798)4.16299374
13Cervical subluxation (HP:0003308)4.16173218
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.14922766
15Soft skin (HP:0000977)4.11197497
16Slender build (HP:0001533)4.06243177
17Cerebral aneurysm (HP:0004944)3.94575337
18Increased variability in muscle fiber diameter (HP:0003557)3.89955519
19Spinal rigidity (HP:0003306)3.86315749
20Shallow orbits (HP:0000586)3.86063447
21Bladder diverticulum (HP:0000015)3.68231881
22Systemic lupus erythematosus (HP:0002725)3.68013792
23Atrophic scars (HP:0001075)3.50699506
24Ulnar deviation of the wrist (HP:0003049)3.47722376
25Abnormality of skeletal muscle fiber size (HP:0012084)3.45160419
26Neck muscle weakness (HP:0000467)3.43948051
27Sudden death (HP:0001699)3.35132732
28Asymmetric septal hypertrophy (HP:0001670)3.33056916
29Oligomenorrhea (HP:0000876)3.30971800
30Distal arthrogryposis (HP:0005684)3.30614772
31Mildly elevated creatine phosphokinase (HP:0008180)3.29677643
32Dilatation of the ascending aorta (HP:0005111)3.28127970
33Bundle branch block (HP:0011710)3.18818174
34Mitral valve prolapse (HP:0001634)3.16152404
35Muscle fiber splitting (HP:0003555)3.10837168
36Ventricular tachycardia (HP:0004756)3.09866661
37Vascular tortuosity (HP:0004948)3.07663475
38EMG: myopathic abnormalities (HP:0003458)3.01684323
39Abnormality of the calf musculature (HP:0001430)2.99579036
40Distal lower limb muscle weakness (HP:0009053)2.93784791
41Round ear (HP:0100830)2.91294848
42Fragile skin (HP:0001030)2.91003323
43Peritonitis (HP:0002586)2.87781209
44Complement deficiency (HP:0004431)2.86199006
45Aneurysm (HP:0002617)2.84434894
46Wormian bones (HP:0002645)2.84426755
47Neonatal short-limb short stature (HP:0008921)2.83255344
48Muscle hypertrophy of the lower extremities (HP:0008968)2.70739477
49Vertebral compression fractures (HP:0002953)2.68850917
50Calf muscle hypertrophy (HP:0008981)2.67089476
51Atrial fibrillation (HP:0005110)2.66297185
52Blue sclerae (HP:0000592)2.64405154
53Elbow flexion contracture (HP:0002987)2.62519230
54Striae distensae (HP:0001065)2.62309223
55Abnormality of dentin (HP:0010299)2.56843900
56Arterial tortuosity (HP:0005116)2.53794006
57Hyporeflexia of lower limbs (HP:0002600)2.50110910
58Bell-shaped thorax (HP:0001591)2.49537087
59Joint stiffness (HP:0001387)2.48038312
60Hypercortisolism (HP:0001578)2.47694295
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.44803500
62Osteolytic defects of the hand bones (HP:0009699)2.44803500
63Abnormal delivery (HP:0001787)2.43913890
64Hyperextensible skin (HP:0000974)2.41904785
65Dilated cardiomyopathy (HP:0001644)2.41139555
66Bulbar palsy (HP:0001283)2.39965502
67Rhabdomyolysis (HP:0003201)2.39446151
68Primary atrial arrhythmia (HP:0001692)2.39237477
69Spondylolisthesis (HP:0003302)2.38920334
70Facial diplegia (HP:0001349)2.37809578
71Joint laxity (HP:0001388)2.36259932
72Biconcave vertebral bodies (HP:0004586)2.34095635
73Hypoventilation (HP:0002791)2.31529049
74Hypoplasia of the iris (HP:0007676)2.30572722
75Mitral stenosis (HP:0001718)2.30514740
76Supraventricular tachycardia (HP:0004755)2.30158560
77Generalized amyotrophy (HP:0003700)2.27946147
78Abnormal atrioventricular conduction (HP:0005150)2.27811118
79Myoglobinuria (HP:0002913)2.27572103
80Supraventricular arrhythmia (HP:0005115)2.26989364
81Hip contracture (HP:0003273)2.26416676
82Limb-girdle muscle weakness (HP:0003325)2.26143695
83Hemorrhage of the eye (HP:0011885)2.24901860
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.24723501
85Stridor (HP:0010307)2.23862405
86Foot dorsiflexor weakness (HP:0009027)2.22931107
87Overgrowth (HP:0001548)2.22801887
88Myotonia (HP:0002486)2.22364855
89Myopathic facies (HP:0002058)2.20994924
90Aortic regurgitation (HP:0001659)2.20202697
91Frequent falls (HP:0002359)2.20146016
92Heart block (HP:0012722)2.19789139
93Thin bony cortex (HP:0002753)2.19274002
94Calcaneovalgus deformity (HP:0001848)2.18468215
95Abnormality of the foot musculature (HP:0001436)2.17630356
96Absent phalangeal crease (HP:0006109)2.16938028
97Genu recurvatum (HP:0002816)2.16576100
98Abnormality of the acetabulum (HP:0003170)2.15764191
99Distal lower limb amyotrophy (HP:0008944)2.15623547
100Mesangial abnormality (HP:0001966)2.15392485
101Limited hip movement (HP:0008800)2.14352513
102Polycythemia (HP:0001901)2.12268813
103Exercise-induced muscle cramps (HP:0003710)2.12072260
104Abnormality of complement system (HP:0005339)2.10785914
105Glomerulonephritis (HP:0000099)2.10749253
106Syncope (HP:0001279)2.09317639
107Pigmentary retinal degeneration (HP:0001146)2.08788582
108Hand muscle atrophy (HP:0009130)2.07510020
109Rectal prolapse (HP:0002035)2.07101239
110Ectopia lentis (HP:0001083)2.06160980
111Bowel diverticulosis (HP:0005222)2.04913459
112Flat cornea (HP:0007720)2.04290982
113Right ventricular cardiomyopathy (HP:0011663)2.03799759
114Male infertility (HP:0003251)2.02227312
115Atrioventricular block (HP:0001678)2.02048655
116Abnormality of the left ventricular outflow tract (HP:0011103)2.01142619
117Subaortic stenosis (HP:0001682)2.01142619
118Muscle stiffness (HP:0003552)2.00688119
119Hypertriglyceridemia (HP:0002155)2.00553195
120Upper limb amyotrophy (HP:0009129)2.00202448
121Distal upper limb amyotrophy (HP:0007149)2.00202448
122Rimmed vacuoles (HP:0003805)1.99587113
123Wide anterior fontanel (HP:0000260)1.98524249
124Alopecia of scalp (HP:0002293)1.96462057
125Proximal amyotrophy (HP:0007126)1.95094007
126Ventricular arrhythmia (HP:0004308)1.92712178
127Deformed tarsal bones (HP:0008119)1.92643321
128Skin nodule (HP:0200036)1.91467899
129Venous abnormality (HP:0002624)1.91443567
130Mitral regurgitation (HP:0001653)1.90012797
131Scapular winging (HP:0003691)1.87539625
132Emphysema (HP:0002097)1.86637490
133Abnormal finger flexion creases (HP:0006143)1.86625381
134Myocardial infarction (HP:0001658)1.85348304
135Venous insufficiency (HP:0005293)1.83718879
136Knee flexion contracture (HP:0006380)1.82849520
137Abnormal cartilage morphology (HP:0002763)1.82599434
138Difficulty running (HP:0009046)1.81591806
139Tarsal synostosis (HP:0008368)1.81160313
140Pulmonary artery stenosis (HP:0004415)1.79764007
141Spinal cord lesions (HP:0100561)1.79547419
142Syringomyelia (HP:0003396)1.79547419
143Deep venous thrombosis (HP:0002625)1.78012396
144Inguinal hernia (HP:0000023)1.77060912
145Disproportionate tall stature (HP:0001519)1.76439576
146Osteoarthritis (HP:0002758)1.75958451
147Tibial bowing (HP:0002982)1.74925982
148Broad ribs (HP:0000885)1.74170738
149Buphthalmos (HP:0000557)1.74059988
150Camptodactyly of toe (HP:0001836)1.73264665
151Delayed closure of the anterior fontanelle (HP:0001476)1.72091136
152Exercise-induced myalgia (HP:0003738)1.71142892
153Acanthosis nigricans (HP:0000956)1.71016910
154Lymphangioma (HP:0100764)1.70167825
155Cardiovascular calcification (HP:0011915)1.69102884
156Hypoalphalipoproteinemia (HP:0003233)1.67792355
157Lipoatrophy (HP:0100578)1.67437046
158Breech presentation (HP:0001623)1.65877741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.73399252
2TRIB34.53456603
3TTN4.26699501
4SIK13.78204675
5ERN13.14323274
6PDGFRA2.95007860
7RIPK12.83025710
8LATS12.61174546
9MYLK2.31107374
10PKN22.29080352
11TGFBR22.09817430
12CAMK1D2.02584927
13PTK61.84263006
14PDK41.81685840
15PDK31.81685840
16FER1.69163119
17EPHB11.65650180
18LMTK21.57554498
19ICK1.49067760
20GRK11.46068137
21EPHB21.39938421
22BCKDK1.38077204
23LATS21.37940498
24MAP3K61.35612192
25CAMK1G1.34393095
26PAK21.33559887
27DMPK1.33441759
28EPHA31.32215173
29FGFR41.24615799
30EEF2K1.24612667
31MST1R1.24416023
32PINK11.23700781
33ABL21.21560922
34STK31.20536929
35TRPM71.18657193
36PDK21.15605202
37CDK121.10171935
38MAPK41.10077141
39MUSK1.09697894
40MAPK71.08866400
41FGFR21.07539984
42MET1.06705324
43TYRO31.04904918
44CAMK11.02124195
45TESK11.01785826
46BMX0.98344411
47STK38L0.96140112
48NLK0.94595682
49PDGFRB0.94516690
50PAK40.92214486
51FLT30.92197562
52MTOR0.91829400
53JAK10.91426351
54PTK20.88887884
55PIK3CG0.88843588
56WNK10.88298690
57PHKG20.87171244
58PHKG10.87171244
59PKN10.86837298
60FRK0.85026538
61MAPKAPK30.83370185
62FGFR30.82937215
63PTK2B0.81211290
64ROCK10.79626546
65PIK3CA0.78099693
66NEK90.77345313
67TYK20.76758000
68MAP3K30.76402845
69FGFR10.74954085
70MAP2K10.74713096
71ARAF0.74534937
72OBSCN0.73302426
73INSRR0.71631801
74MOS0.70766475
75CAMK2D0.70341928
76KDR0.70196966
77GRK50.70033198
78CAMK2G0.69659191
79MAP2K30.67092425
80PAK30.64303489
81AKT30.63181822
82PDPK10.62453826
83MARK20.62363067
84ACVR1B0.62071567
85RET0.60285813
86PRKD20.59559975
87MAP3K100.59547997
88PRKAA20.58199017
89PRKACG0.58019925
90BLK0.57641636
91PRKCH0.57288013
92GSK3A0.57010115
93CSK0.56987891
94PRPF4B0.56712936
95PRKG10.55979968
96ILK0.55738487
97RPS6KL10.55467366
98RPS6KC10.55467366
99MAP3K70.55466168
100MAP3K10.54578947
101LIMK10.53474102
102STK240.53403114
103PRKD10.52277860
104TIE10.48999256
105MAPK150.48989270
106PRKD30.48806457
107ZAP700.48640031
108RPS6KA60.48243214
109PIM20.46678998
110PRKG20.45792220
111CDK60.45443939
112CDK90.44601527
113LRRK20.44440205
114MAP3K130.43746997
115AKT20.43454020
116CAMK2B0.43351996
117NUAK10.42967203
118CHUK0.41656967
119MAPKAPK50.41427089
120ADRBK10.41332531
121DAPK30.41210725
122TGFBR10.38505426
123CDC42BPA0.38126883
124NTRK10.37845985
125MAP2K20.36646003
126DAPK20.36509204
127ROCK20.35740817
128INSR0.33591918
129MAPK110.32887843
130JAK30.32462228
131KIT0.32228125
132PRKAA10.30448276
133CSF1R0.29645454
134STK380.29293077
135SRC0.29132774
136RPS6KA20.28813273
137IRAK10.27528380
138MAPK120.26650203
139MAPK10.26502872
140JAK20.26052627
141EPHA20.25876538
142ERBB20.25434440

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.81948294
2PPAR signaling pathway_Homo sapiens_hsa033202.56099095
3Complement and coagulation cascades_Homo sapiens_hsa046102.53368094
4Protein digestion and absorption_Homo sapiens_hsa049742.50904233
5Focal adhesion_Homo sapiens_hsa045102.38420280
6Fatty acid metabolism_Homo sapiens_hsa012122.34245150
7Fatty acid degradation_Homo sapiens_hsa000712.32840699
8Fatty acid biosynthesis_Homo sapiens_hsa000612.22544399
9Propanoate metabolism_Homo sapiens_hsa006402.16056335
10Amoebiasis_Homo sapiens_hsa051462.04468746
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97376447
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.85787695
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.68529294
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57742708
15Renin secretion_Homo sapiens_hsa049241.53872322
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.47224565
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47035304
18Caffeine metabolism_Homo sapiens_hsa002321.46081865
19Small cell lung cancer_Homo sapiens_hsa052221.42046469
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40708014
21Nitrogen metabolism_Homo sapiens_hsa009101.39255901
22Tryptophan metabolism_Homo sapiens_hsa003801.38449249
23Proteoglycans in cancer_Homo sapiens_hsa052051.37739472
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37536683
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37370508
26Staphylococcus aureus infection_Homo sapiens_hsa051501.34955268
27Adherens junction_Homo sapiens_hsa045201.33807921
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.29173220
29Circadian rhythm_Homo sapiens_hsa047101.27738107
30Dilated cardiomyopathy_Homo sapiens_hsa054141.27510190
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26932900
32Insulin resistance_Homo sapiens_hsa049311.26435819
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20531646
34TGF-beta signaling pathway_Homo sapiens_hsa043501.18755695
35Renin-angiotensin system_Homo sapiens_hsa046141.18118396
36Pyruvate metabolism_Homo sapiens_hsa006201.17738281
37Lysine degradation_Homo sapiens_hsa003101.14727533
38beta-Alanine metabolism_Homo sapiens_hsa004101.12259097
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10146583
40Basal cell carcinoma_Homo sapiens_hsa052171.09051939
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06529440
42Phenylalanine metabolism_Homo sapiens_hsa003601.04383396
43Starch and sucrose metabolism_Homo sapiens_hsa005001.03931354
44Arachidonic acid metabolism_Homo sapiens_hsa005901.03263545
45Mineral absorption_Homo sapiens_hsa049781.03073195
46AMPK signaling pathway_Homo sapiens_hsa041521.01312288
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00779102
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00136197
49Arginine and proline metabolism_Homo sapiens_hsa003300.99379093
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99351780
51Malaria_Homo sapiens_hsa051440.99008384
52Chemical carcinogenesis_Homo sapiens_hsa052040.95802454
53Viral myocarditis_Homo sapiens_hsa054160.95221866
54Toxoplasmosis_Homo sapiens_hsa051450.93731202
55Pertussis_Homo sapiens_hsa051330.93446423
56Arginine biosynthesis_Homo sapiens_hsa002200.92639674
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90954640
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.90667175
59Linoleic acid metabolism_Homo sapiens_hsa005910.87515232
60Hedgehog signaling pathway_Homo sapiens_hsa043400.85412095
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84864586
62Cardiac muscle contraction_Homo sapiens_hsa042600.84750107
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83955099
64Glycerolipid metabolism_Homo sapiens_hsa005610.83450105
65Sulfur metabolism_Homo sapiens_hsa009200.82726988
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.82514714
67Carbon metabolism_Homo sapiens_hsa012000.82091452
68Fat digestion and absorption_Homo sapiens_hsa049750.81253526
69Prion diseases_Homo sapiens_hsa050200.78105335
70Insulin signaling pathway_Homo sapiens_hsa049100.75861731
71Tyrosine metabolism_Homo sapiens_hsa003500.75527825
72Phototransduction_Homo sapiens_hsa047440.74999514
73Bladder cancer_Homo sapiens_hsa052190.74781526
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74378071
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73494722
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72942849
77Peroxisome_Homo sapiens_hsa041460.72444629
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.70925478
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70584360
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.69581750
81Vitamin digestion and absorption_Homo sapiens_hsa049770.68865544
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67941809
83Ovarian steroidogenesis_Homo sapiens_hsa049130.65155621
84Bile secretion_Homo sapiens_hsa049760.64416272
85ABC transporters_Homo sapiens_hsa020100.64107897
86Fatty acid elongation_Homo sapiens_hsa000620.64049706
87Oxytocin signaling pathway_Homo sapiens_hsa049210.63312046
88Pancreatic secretion_Homo sapiens_hsa049720.62268733
89Pathways in cancer_Homo sapiens_hsa052000.61358556
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61249030
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60833991
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60508262
93Glucagon signaling pathway_Homo sapiens_hsa049220.60257758
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.60047618
95Hippo signaling pathway_Homo sapiens_hsa043900.59913007
96Butanoate metabolism_Homo sapiens_hsa006500.58311342
97Sulfur relay system_Homo sapiens_hsa041220.57958445
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57378147
99Lysosome_Homo sapiens_hsa041420.57163881
100Dorso-ventral axis formation_Homo sapiens_hsa043200.57033782
101Chronic myeloid leukemia_Homo sapiens_hsa052200.56791431
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56420243
103MicroRNAs in cancer_Homo sapiens_hsa052060.56187633
104Melanoma_Homo sapiens_hsa052180.55732927
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.54414008
106Tight junction_Homo sapiens_hsa045300.53729903
107Prostate cancer_Homo sapiens_hsa052150.53564968
108Calcium signaling pathway_Homo sapiens_hsa040200.51527381
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51017875
110Platelet activation_Homo sapiens_hsa046110.50301656
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.48763689
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48747512
113Retinol metabolism_Homo sapiens_hsa008300.48317876
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48203510
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47469460
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47215328
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46576413
118GnRH signaling pathway_Homo sapiens_hsa049120.45755931
119Histidine metabolism_Homo sapiens_hsa003400.44494899
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43567800
121FoxO signaling pathway_Homo sapiens_hsa040680.43018495
122Pancreatic cancer_Homo sapiens_hsa052120.41102976
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41062205
124cAMP signaling pathway_Homo sapiens_hsa040240.38628980
125Endometrial cancer_Homo sapiens_hsa052130.37667867
126mTOR signaling pathway_Homo sapiens_hsa041500.37621784
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35217185
128Melanogenesis_Homo sapiens_hsa049160.33869094
129Gap junction_Homo sapiens_hsa045400.33532438
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33270227
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30564301
132Gastric acid secretion_Homo sapiens_hsa049710.29930888

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