SCARB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to follicle-stimulating hormone (GO:0032354)6.89015984
2C21-steroid hormone biosynthetic process (GO:0006700)6.15312017
3alpha-linolenic acid metabolic process (GO:0036109)5.96134121
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.69178002
5L-phenylalanine catabolic process (GO:0006559)5.69178002
6cellular response to gonadotropin stimulus (GO:0071371)5.50110597
7L-phenylalanine metabolic process (GO:0006558)5.49624822
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.49624822
9regulation of cholesterol biosynthetic process (GO:0045540)5.44079460
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.40442841
11bile acid biosynthetic process (GO:0006699)5.34676067
12estrogen biosynthetic process (GO:0006703)5.31932089
13glucocorticoid biosynthetic process (GO:0006704)5.23456600
14aromatic amino acid family catabolic process (GO:0009074)5.15254036
15complement activation, alternative pathway (GO:0006957)5.00924441
16glyoxylate metabolic process (GO:0046487)4.99938007
17protein carboxylation (GO:0018214)4.93770075
18peptidyl-glutamic acid carboxylation (GO:0017187)4.93770075
19negative regulation of fibrinolysis (GO:0051918)4.88650682
20cellular response to antibiotic (GO:0071236)4.86605305
21positive regulation of hormone biosynthetic process (GO:0046886)4.81679489
22kynurenine metabolic process (GO:0070189)4.80598394
23regulation of protein activation cascade (GO:2000257)4.80174524
24C21-steroid hormone metabolic process (GO:0008207)4.75551191
25indolalkylamine catabolic process (GO:0046218)4.70162769
26tryptophan catabolic process (GO:0006569)4.70162769
27indole-containing compound catabolic process (GO:0042436)4.70162769
28* high-density lipoprotein particle remodeling (GO:0034375)4.67945177
29urea metabolic process (GO:0019627)4.60244966
30urea cycle (GO:0000050)4.60244966
31glucocorticoid metabolic process (GO:0008211)4.57248421
32sulfur amino acid catabolic process (GO:0000098)4.57215089
33regulation of complement activation (GO:0030449)4.53868825
34regulation of fibrinolysis (GO:0051917)4.53122822
35* androgen biosynthetic process (GO:0006702)4.49146183
36benzene-containing compound metabolic process (GO:0042537)4.44804528
37regulation of triglyceride catabolic process (GO:0010896)4.41630904
38tryptophan metabolic process (GO:0006568)4.41281240
39bile acid metabolic process (GO:0008206)4.36059649
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34787274
41intestinal cholesterol absorption (GO:0030299)4.32428006
42amyloid precursor protein catabolic process (GO:0042987)4.29911150
43* reverse cholesterol transport (GO:0043691)4.28501701
44positive regulation of hormone metabolic process (GO:0032352)4.28486660
45* acylglycerol homeostasis (GO:0055090)4.22707094
46* triglyceride homeostasis (GO:0070328)4.22707094
47nitrogen cycle metabolic process (GO:0071941)4.20641186
48* plasma lipoprotein particle clearance (GO:0034381)4.16755283
49cysteine metabolic process (GO:0006534)4.15893023
50lysine metabolic process (GO:0006553)4.14389600
51lysine catabolic process (GO:0006554)4.14389600
52response to gonadotropin (GO:0034698)4.08903467
53cellular response to cadmium ion (GO:0071276)4.04642417
54* plasma lipoprotein particle remodeling (GO:0034369)4.03266071
55* protein-lipid complex remodeling (GO:0034368)4.03266071
56* macromolecular complex remodeling (GO:0034367)4.03266071
57progesterone metabolic process (GO:0042448)4.02656768
58amino-acid betaine metabolic process (GO:0006577)4.02085377
59positive regulation of lipoprotein lipase activity (GO:0051006)3.99586212
60positive regulation of triglyceride lipase activity (GO:0061365)3.99586212
61homocysteine metabolic process (GO:0050667)3.92329953
62phospholipid efflux (GO:0033700)3.84981395
63regulation of cholesterol esterification (GO:0010872)3.81072219
64serine family amino acid catabolic process (GO:0009071)3.80366910
65tyrosine metabolic process (GO:0006570)3.76167449
66cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.73137417
67proline biosynthetic process (GO:0006561)3.71723617
68linoleic acid metabolic process (GO:0043651)3.69251004
69proline metabolic process (GO:0006560)3.67201204
70aromatic amino acid family metabolic process (GO:0009072)3.66786967
71plasma lipoprotein particle assembly (GO:0034377)3.66483834
72* cholesterol efflux (GO:0033344)3.64509267
73ethanol oxidation (GO:0006069)3.61112561
74alpha-amino acid catabolic process (GO:1901606)3.59987918
75phospholipid homeostasis (GO:0055091)3.58483547
76negative regulation of cholesterol transport (GO:0032375)3.57155910
77negative regulation of sterol transport (GO:0032372)3.57155910
78regulation of apoptotic cell clearance (GO:2000425)3.55884064
79Golgi transport vesicle coating (GO:0048200)3.53756191
80COPI coating of Golgi vesicle (GO:0048205)3.53756191
81positive regulation of lipid catabolic process (GO:0050996)3.48266314
82glycine metabolic process (GO:0006544)3.46515630
83valine metabolic process (GO:0006573)3.45673073
84fibrinolysis (GO:0042730)3.44920758
85very-low-density lipoprotein particle assembly (GO:0034379)3.44679387
86* cholesterol homeostasis (GO:0042632)3.44292789
87* sterol metabolic process (GO:0016125)3.42205772
88positive regulation of male gonad development (GO:2000020)3.39812216
89regulation of steroid biosynthetic process (GO:0050810)3.39739988
90* sterol homeostasis (GO:0055092)3.39191710
91regulation of plasminogen activation (GO:0010755)3.37939230
92regulation of cholesterol homeostasis (GO:2000188)3.37808705
93positive regulation of fatty acid beta-oxidation (GO:0032000)3.37766927
94* cholesterol metabolic process (GO:0008203)3.37253346
95positive regulation of steroid metabolic process (GO:0045940)3.36422089
96negative regulation of lipase activity (GO:0060192)3.34968488
97bile acid and bile salt transport (GO:0015721)3.34225589
98blood coagulation, intrinsic pathway (GO:0007597)3.34159270
99imidazole-containing compound metabolic process (GO:0052803)3.32955360
100cellular amino acid catabolic process (GO:0009063)3.32145783
101protein-lipid complex assembly (GO:0065005)3.31882220
102cellular glucuronidation (GO:0052695)3.31444331
103cellular response to toxic substance (GO:0097237)3.31064390
104* plasma lipoprotein particle organization (GO:0071827)3.28849104
105low-density lipoprotein particle remodeling (GO:0034374)3.28181227
106negative regulation of fatty acid transport (GO:2000192)3.27243785
1072-oxoglutarate metabolic process (GO:0006103)3.27177190
108protein activation cascade (GO:0072376)3.25933587
109complement activation (GO:0006956)3.24854102
110* androgen metabolic process (GO:0008209)3.24735626
111regulation of cholesterol metabolic process (GO:0090181)3.24156807
112carnitine metabolic process (GO:0009437)3.22798152
113arginine metabolic process (GO:0006525)3.21516104
114cellular modified amino acid catabolic process (GO:0042219)3.20816237
115* lipoprotein metabolic process (GO:0042157)3.20312432
116cellular biogenic amine catabolic process (GO:0042402)3.20081287
117amine catabolic process (GO:0009310)3.20081287
118cellular ketone body metabolic process (GO:0046950)3.17829658
119fatty acid oxidation (GO:0019395)3.17693960
120fatty acid beta-oxidation (GO:0006635)3.17458939
121epoxygenase P450 pathway (GO:0019373)3.16878673
122* positive regulation of triglyceride metabolic process (GO:0090208)3.16724365
123* low-density lipoprotein particle clearance (GO:0034383)3.16579354
124indolalkylamine metabolic process (GO:0006586)3.16187937
125response to phenylpropanoid (GO:0080184)3.15276791
126regulation of steroid hormone biosynthetic process (GO:0090030)3.15197812
127response to insecticide (GO:0017085)3.14708519
128* hormone biosynthetic process (GO:0042446)3.13520284
129* protein-lipid complex subunit organization (GO:0071825)3.08843483
130regulation of gonadotropin secretion (GO:0032276)3.08260155
131negative regulation of fatty acid biosynthetic process (GO:0045717)3.06319463
132Leydig cell differentiation (GO:0033327)3.06145722
133cholesterol biosynthetic process (GO:0006695)3.02779971
134basement membrane organization (GO:0071711)2.99292868
135hemoglobin metabolic process (GO:0020027)2.99155244
136dicarboxylic acid biosynthetic process (GO:0043650)2.97762690
137positive regulation of steroid biosynthetic process (GO:0010893)2.97689073
138negative regulation of lipid transport (GO:0032369)2.96544492
139regulation of steroid metabolic process (GO:0019218)2.96347549
140* cholesterol transport (GO:0030301)2.93739808
141* sterol transport (GO:0015918)2.93739808
142glucose 6-phosphate metabolic process (GO:0051156)2.92386567
143positive regulation of extracellular matrix organization (GO:1903055)2.89576726
144regulation of fatty acid biosynthetic process (GO:0042304)2.88972180
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86820560
146positive regulation of fatty acid biosynthetic process (GO:0045723)2.85807058
147mating behavior (GO:0007617)2.85764532
148biotin metabolic process (GO:0006768)2.82514791
149glutamine family amino acid biosynthetic process (GO:0009084)2.81475997
150protein retention in ER lumen (GO:0006621)2.79229184
151* steroid biosynthetic process (GO:0006694)2.77824427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.98722746
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.99252091
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.15441267
4* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.14576801
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.54144857
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.12614129
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.34975039
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.02964360
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.37772334
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.05463211
11* CLOCK_20551151_ChIP-Seq_293T_Human2.86340309
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.82225798
13E2F7_22180533_ChIP-Seq_HELA_Human2.19807888
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.07627968
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.95775914
16* VDR_21846776_ChIP-Seq_THP-1_Human1.85752639
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79265580
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76472400
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73760797
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72113879
21GATA1_22025678_ChIP-Seq_K562_Human1.71644992
22* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69270864
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65754032
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62414337
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61428693
26* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59361644
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57347293
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.51720793
29* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49920556
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46529869
31KDM2B_26808549_Chip-Seq_K562_Human1.42639374
32* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41774288
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35115496
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.34734825
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33187154
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27585003
37* LXR_22292898_ChIP-Seq_THP-1_Human1.27239259
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.26952962
39* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26647755
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.24978099
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24847331
42AR_21909140_ChIP-Seq_LNCAP_Human1.24378397
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24154032
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23378549
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23280978
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.21439865
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.19626896
48P68_20966046_ChIP-Seq_HELA_Human1.19606555
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19553593
50* KDM2B_26808549_Chip-Seq_DND41_Human1.17171326
51SMC4_20622854_ChIP-Seq_HELA_Human1.16847053
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16495427
53* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15497804
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15083956
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.14689596
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.14234203
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13398671
58* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12924995
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12550753
60GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.12377691
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11969681
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11838960
63ZNF263_19887448_ChIP-Seq_K562_Human1.11670251
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10388524
65* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09614020
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08823067
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08785475
68GATA1_19941826_ChIP-Seq_K562_Human1.08606274
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.07998047
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07991924
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07817312
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07109776
73CREB1_26743006_Chip-Seq_LNCaP_Human1.06733028
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06724293
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06556196
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06236184
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05756782
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05718407
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.04577365
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03232013
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.03077664
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03071928
83* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02393444
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00759582
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99050779
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98463710
87MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98224156
88SCL_19346495_ChIP-Seq_HPC-7_Human0.94266412
89* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94252727
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94251021
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.94183827
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93057142
93* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90469689
94* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89797070
95* RACK7_27058665_Chip-Seq_MCF-7_Human0.89644483
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88436026
97SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88305485
98GATA4_25053715_ChIP-Seq_YYC3_Human0.87057339
99* GATA1_19941827_ChIP-Seq_MEL_Mouse0.85405615
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84631141
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77036661
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75725774
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75324211
104* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.74327745
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74252845
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74167301
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74135302
108TBX20_22328084_ChIP-Seq_HEART_Mouse0.73199395
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.73199395
110* GATA2_19941826_ChIP-Seq_K562_Human0.72318826
111ATF3_27146783_Chip-Seq_COLON_Human0.72144304
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.69720908
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69188858
114HTT_18923047_ChIP-ChIP_STHdh_Human0.68853304
115NCOR1_26117541_ChIP-Seq_K562_Human0.68605394
116* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67740095
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67046166
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.66772250
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.66713118
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.66359902
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66004506
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65849546
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65292717
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.64619591
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.64571691
126TCF7_22412390_ChIP-Seq_EML_Mouse0.63806713
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63511176
128* MYC_22102868_ChIP-Seq_BL_Human0.63448191
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63440683
130* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.62488706
131* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62065065
132* CDX2_20551321_ChIP-Seq_CACO-2_Human0.61619764
133GATA6_25053715_ChIP-Seq_YYC3_Human0.61436991
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.60086909
135* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.58990048
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.58845719
137* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.58633515
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58517796
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.57351895
140BCL6_27268052_Chip-Seq_Bcells_Human0.56790489
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.56732339
142CEBPB_22108803_ChIP-Seq_LS180_Human0.56156492
143RARB_24833708_ChIP-Seq_LIVER_Mouse0.56117471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.53195965
2MP0005360_urolithiasis5.95256293
3MP0005365_abnormal_bile_salt5.10237174
4MP0005085_abnormal_gallbladder_physiolo4.98603564
5MP0008875_abnormal_xenobiotic_pharmacok4.03886708
6* MP0010329_abnormal_lipoprotein_level3.43678675
7MP0009840_abnormal_foam_cell3.16557412
8MP0003252_abnormal_bile_duct3.04545112
9MP0003806_abnormal_nucleotide_metabolis2.96042270
10MP0003191_abnormal_cellular_cholesterol2.86091612
11MP0010368_abnormal_lymphatic_system2.52486041
12MP0005083_abnormal_biliary_tract2.45348270
13MP0002877_abnormal_melanocyte_morpholog2.40537419
14MP0005076_abnormal_cell_differentiation2.32142889
15MP0005670_abnormal_white_adipose2.29950405
16MP0004233_abnormal_muscle_weight2.23340133
17* MP0000609_abnormal_liver_physiology2.17429037
18MP0005319_abnormal_enzyme/_coenzyme2.16530715
19MP0003705_abnormal_hypodermis_morpholog2.11158944
20MP0008004_abnormal_stomach_pH2.02669979
21MP0003195_calcinosis2.01496349
22MP0005332_abnormal_amino_acid1.99986959
23MP0001666_abnormal_nutrient_absorption1.97905262
24* MP0002118_abnormal_lipid_homeostasis1.95931685
25MP0000639_abnormal_adrenal_gland1.91938671
26MP0003724_increased_susceptibility_to1.80928744
27MP0005409_darkened_coat_color1.80001345
28MP0003122_maternal_imprinting1.75260479
29MP0004019_abnormal_vitamin_homeostasis1.71074406
30MP0005647_abnormal_sex_gland1.67309234
31MP0002089_abnormal_postnatal_growth/wei1.66190961
32MP0003172_abnormal_lysosome_physiology1.64575276
33MP0003186_abnormal_redox_activity1.62625985
34MP0000003_abnormal_adipose_tissue1.56165965
35MP0003011_delayed_dark_adaptation1.53231811
36MP0003315_abnormal_perineum_morphology1.48857157
37MP0005584_abnormal_enzyme/coenzyme_acti1.48168934
38MP0002138_abnormal_hepatobiliary_system1.45847853
39MP0005257_abnormal_intraocular_pressure1.44086406
40MP0003656_abnormal_erythrocyte_physiolo1.43837866
41MP0001764_abnormal_homeostasis1.43827553
42MP0003329_amyloid_beta_deposits1.43705219
43MP0000598_abnormal_liver_morphology1.38241205
44MP0000678_abnormal_parathyroid_gland1.37298112
45MP0010234_abnormal_vibrissa_follicle1.28662200
46MP0009643_abnormal_urine_homeostasis1.27806048
47MP0001879_abnormal_lymphatic_vessel1.24049207
48MP0000566_synostosis1.21218274
49MP0009697_abnormal_copulation1.21091840
50MP0005167_abnormal_blood-brain_barrier1.19469839
51MP0003868_abnormal_feces_composition1.18060472
52MP0004130_abnormal_muscle_cell1.13891072
53MP0008995_early_reproductive_senescence1.13673157
54MP0008260_abnormal_autophagy1.13433452
55MP0003300_gastrointestinal_ulcer1.11244734
56MP0003123_paternal_imprinting1.10180456
57MP0009763_increased_sensitivity_to1.08768923
58MP0005666_abnormal_adipose_tissue1.05994318
59MP0001661_extended_life_span1.05713309
60* MP0008469_abnormal_protein_level1.05305445
61MP0005636_abnormal_mineral_homeostasis1.04562253
62MP0008438_abnormal_cutaneous_collagen1.03838600
63MP0004858_abnormal_nervous_system1.03377448
64MP0009764_decreased_sensitivity_to1.03136079
65MP0002909_abnormal_adrenal_gland1.02737719
66MP0000013_abnormal_adipose_tissue0.99460787
67MP0009672_abnormal_birth_weight0.98261087
68MP0002269_muscular_atrophy0.96587636
69MP0002254_reproductive_system_inflammat0.96058698
70MP0004272_abnormal_basement_membrane0.95610980
71MP0005464_abnormal_platelet_physiology0.91326274
72MP0005334_abnormal_fat_pad0.90914416
73MP0001849_ear_inflammation0.89579736
74MP0003436_decreased_susceptibility_to0.87725862
75MP0002971_abnormal_brown_adipose0.87187831
76* MP0009642_abnormal_blood_homeostasis0.87125373
77MP0004147_increased_porphyrin_level0.85888189
78MP0001756_abnormal_urination0.85249616
79MP0001730_embryonic_growth_arrest0.83833381
80MP0002896_abnormal_bone_mineralization0.82081963
81MP0000343_altered_response_to0.81655829
82MP0001881_abnormal_mammary_gland0.80217066
83MP0003283_abnormal_digestive_organ0.78986627
84MP0002876_abnormal_thyroid_physiology0.78291294
85MP0009278_abnormal_bone_marrow0.77334020
86MP0009115_abnormal_fat_cell0.75246495
87MP0005451_abnormal_body_composition0.75215621
88* MP0000249_abnormal_blood_vessel0.75185844
89MP0002078_abnormal_glucose_homeostasis0.74882718
90MP0006054_spinal_hemorrhage0.74315793
91MP0003638_abnormal_response/metabolism_0.74164016
92MP0000230_abnormal_systemic_arterial0.74061732
93MP0004185_abnormal_adipocyte_glucose0.73629206
94MP0004264_abnormal_extraembryonic_tissu0.73621766
95MP0003111_abnormal_nucleus_morphology0.72704497
96MP0005397_hematopoietic_system_phenotyp0.71617887
97MP0001545_abnormal_hematopoietic_system0.71617887
98MP0003941_abnormal_skin_development0.71060563
99MP0008007_abnormal_cellular_replicative0.70841430
100* MP0005376_homeostasis/metabolism_phenot0.70038808
101MP0000604_amyloidosis0.69057994
102MP0005330_cardiomyopathy0.68348584
103* MP0003699_abnormal_female_reproductive0.67739861
104MP0003959_abnormal_lean_body0.67635355
105MP0003566_abnormal_cell_adhesion0.67417776
106MP0003453_abnormal_keratinocyte_physiol0.67281747
107MP0005187_abnormal_penis_morphology0.66429122
108MP0010630_abnormal_cardiac_muscle0.65160451
109MP0005023_abnormal_wound_healing0.65013548
110MP0003091_abnormal_cell_migration0.64920003
111MP0001915_intracranial_hemorrhage0.63984007
112MP0005220_abnormal_exocrine_pancreas0.63823798
113MP0005408_hypopigmentation0.63778266
114MP0004782_abnormal_surfactant_physiolog0.63390375
115MP0001533_abnormal_skeleton_physiology0.63318857
116MP0003303_peritoneal_inflammation0.62251089
117MP0002970_abnormal_white_adipose0.61356357
118MP0005375_adipose_tissue_phenotype0.61201257
119MP0002249_abnormal_larynx_morphology0.60941135
120MP0002075_abnormal_coat/hair_pigmentati0.60508331
121MP0002086_abnormal_extraembryonic_tissu0.59478151
122MP0003953_abnormal_hormone_level0.59055755
123MP0009780_abnormal_chondrocyte_physiolo0.58922968
124MP0003984_embryonic_growth_retardation0.58547412
125MP0002088_abnormal_embryonic_growth/wei0.57791005
126MP0000462_abnormal_digestive_system0.56849267
127MP0005084_abnormal_gallbladder_morpholo0.56641254
128* MP0005164_abnormal_response_to0.55699880
129MP0002136_abnormal_kidney_physiology0.55305003
130MP0006036_abnormal_mitochondrial_physio0.54333364
131MP0002295_abnormal_pulmonary_circulatio0.53788030
132MP0009053_abnormal_anal_canal0.52647709
133MP0000767_abnormal_smooth_muscle0.52223305
134MP0001853_heart_inflammation0.51985232
135MP0005058_abnormal_lysosome_morphology0.51832740
136MP0005448_abnormal_energy_balance0.50688881
137MP0005595_abnormal_vascular_smooth0.50115904
138MP0002128_abnormal_blood_circulation0.49846571
139MP0009765_abnormal_xenobiotic_induced0.49811726
140MP0002419_abnormal_innate_immunity0.48511812
141MP0003075_altered_response_to0.47985575
142MP0003279_aneurysm0.46582818
143MP0006138_congestive_heart_failure0.46479211
144MP0001765_abnormal_ion_homeostasis0.46337751
145MP0002135_abnormal_kidney_morphology0.45383380

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.81261931
2Intrahepatic cholestasis (HP:0001406)5.84313821
3Xanthomatosis (HP:0000991)5.67796747
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.53913018
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.40436562
6Complement deficiency (HP:0004431)5.25285737
7Prolonged partial thromboplastin time (HP:0003645)5.24213690
8Hypobetalipoproteinemia (HP:0003563)4.91801550
9Hyperlipoproteinemia (HP:0010980)4.89018073
10Joint hemorrhage (HP:0005261)4.51027679
11Hypolipoproteinemia (HP:0010981)4.19392129
12Hypoalphalipoproteinemia (HP:0003233)4.12976381
13Abnormality of the common coagulation pathway (HP:0010990)4.11379271
14Hyperammonemia (HP:0001987)4.10204091
15Abnormality of complement system (HP:0005339)4.03589435
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.00966084
17Epidermoid cyst (HP:0200040)3.98568711
18Hypoglycemic coma (HP:0001325)3.91641749
19Ketosis (HP:0001946)3.75892937
20Abnormality of the intrinsic pathway (HP:0010989)3.62813417
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.57092490
22Hypercholesterolemia (HP:0003124)3.48237658
23Abnormality of carpal bone ossification (HP:0006257)3.47968874
24Hyperglycinemia (HP:0002154)3.40025004
25Hyperglycinuria (HP:0003108)3.37939094
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.34510091
27Relative macrocephaly (HP:0004482)3.33918697
28Myocardial infarction (HP:0001658)3.33326845
29Neonatal onset (HP:0003623)3.29001073
30Fat malabsorption (HP:0002630)3.28845557
31Abnormality of glycine metabolism (HP:0010895)3.28663181
32Abnormality of serine family amino acid metabolism (HP:0010894)3.28663181
33Esophageal varix (HP:0002040)3.21123979
34Abnormality of pyrimidine metabolism (HP:0004353)3.15601469
35Abnormality of methionine metabolism (HP:0010901)3.14909313
36Abnormality of fatty-acid metabolism (HP:0004359)3.12948965
37Enlarged penis (HP:0000040)3.11785633
38Abnormal sex determination (HP:0012244)3.11688979
39Sex reversal (HP:0012245)3.11688979
40Flat acetabular roof (HP:0003180)3.09868700
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.06752498
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.06007323
43Systemic lupus erythematosus (HP:0002725)2.99871627
44Abnormal ossification of hand bones (HP:0005921)2.83972609
45Ulnar bowing (HP:0003031)2.80698940
46Hepatocellular carcinoma (HP:0001402)2.79093724
47Ketoacidosis (HP:0001993)2.71729357
48Hyperbilirubinemia (HP:0002904)2.67977435
49Skin nodule (HP:0200036)2.66079778
50Small epiphyses (HP:0010585)2.65182799
51Hemorrhage of the eye (HP:0011885)2.64370110
52Delayed CNS myelination (HP:0002188)2.62326264
53Recurrent gram-negative bacterial infections (HP:0005420)2.60231507
54Abnormality of nucleobase metabolism (HP:0010932)2.56871159
55Steatorrhea (HP:0002570)2.54569291
56Polycythemia (HP:0001901)2.53162389
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49144741
58Abnormal hand bone ossification (HP:0010660)2.46334366
59Abnormality of glycolysis (HP:0004366)2.43337867
60Pigmentary retinal degeneration (HP:0001146)2.41943147
61Diastasis recti (HP:0001540)2.40988636
62Abnormality of the Achilles tendon (HP:0005109)2.40331763
63Asymmetry of the thorax (HP:0001555)2.39661348
64Renal salt wasting (HP:0000127)2.38969405
65Nausea (HP:0002018)2.37262275
66Spontaneous abortion (HP:0005268)2.36643119
67Testicular neoplasm (HP:0010788)2.36435316
68Hypoglycemic seizures (HP:0002173)2.36030272
69Amyloidosis (HP:0011034)2.36000330
70Thrombophlebitis (HP:0004418)2.35117961
71Abnormal tarsal ossification (HP:0008369)2.33554945
72Dicarboxylic aciduria (HP:0003215)2.32585465
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32585465
74Large earlobe (HP:0009748)2.32548071
75Protrusio acetabuli (HP:0003179)2.31247059
76Urinary glycosaminoglycan excretion (HP:0003541)2.30867097
77Mucopolysacchariduria (HP:0008155)2.30867097
78Abnormality of serum amino acid levels (HP:0003112)2.29380485
79Abnormality of purine metabolism (HP:0004352)2.27506004
80Hypochromic microcytic anemia (HP:0004840)2.26602633
81Spastic diplegia (HP:0001264)2.26550000
82Abnormality of the alveolar ridges (HP:0006477)2.26383939
83Glomerulonephritis (HP:0000099)2.26206866
84Lymphangioma (HP:0100764)2.26116110
85Conjugated hyperbilirubinemia (HP:0002908)2.25434728
86Menorrhagia (HP:0000132)2.25130424
87Hypertriglyceridemia (HP:0002155)2.24665106
88Gonadal dysgenesis (HP:0000133)2.22630160
89Metabolic acidosis (HP:0001942)2.22403070
90Cholecystitis (HP:0001082)2.20727449
91Abnormal gallbladder physiology (HP:0012438)2.20727449
92Abnormality of proline metabolism (HP:0010907)2.19474827
93Hydroxyprolinuria (HP:0003080)2.19474827
94Vascular calcification (HP:0004934)2.18818178
95Gingival bleeding (HP:0000225)2.18771516
96Vertebral compression fractures (HP:0002953)2.17808152
97Cholelithiasis (HP:0001081)2.17342068
98Abnormality of transition element cation homeostasis (HP:0011030)2.13737281
99Seborrheic dermatitis (HP:0001051)2.13204166
100Rhizomelia (HP:0008905)2.12805917
101Abnormal gallbladder morphology (HP:0012437)2.12018674
102Mitral stenosis (HP:0001718)2.10416388
103Abnormality of iron homeostasis (HP:0011031)2.10095172
104Hyperacusis (HP:0010780)2.09534430
105Nephritis (HP:0000123)2.08873958
106Abnormality of polysaccharide metabolism (HP:0011012)2.08552945
107Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08552945
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08552945
109Anomalous pulmonary venous return (HP:0010772)2.05254239
110Premature ovarian failure (HP:0008209)2.03489542
111Cardiovascular calcification (HP:0011915)2.02804503
112Ureteral duplication (HP:0000073)2.02373734
113Pancreatitis (HP:0001733)2.01631483
114Increased serum pyruvate (HP:0003542)2.01460038
115Abnormal cartilage morphology (HP:0002763)2.01341413
116Achilles tendon contracture (HP:0001771)1.99190537
117Acanthosis nigricans (HP:0000956)1.98617229
118Abnormality of the thoracic spine (HP:0100711)1.98390595
119Cupped ribs (HP:0000887)1.97789599
120Acanthocytosis (HP:0001927)1.94722071
121Back pain (HP:0003418)1.93599072
122Growth hormone excess (HP:0000845)1.92804321
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92591094
124Absent epiphyses (HP:0010577)1.92591094
125Azoospermia (HP:0000027)1.91256762
126Overlapping toe (HP:0001845)1.90474765
127Nonimmune hydrops fetalis (HP:0001790)1.89999397
128Neonatal death (HP:0003811)1.88292523
129Reticulocytosis (HP:0001923)1.87293744
130Pulmonary embolism (HP:0002204)1.86063360
131Advanced eruption of teeth (HP:0006288)1.85660352
132Bronchomalacia (HP:0002780)1.85329409
133Dysostosis multiplex (HP:0000943)1.84454310
134Thoracic kyphosis (HP:0002942)1.83849524
135Cerebral aneurysm (HP:0004944)1.83091963
136Poikilocytosis (HP:0004447)1.82434732
137Abnormality of the gallbladder (HP:0005264)1.82213083
138Lethargy (HP:0001254)1.81527895
139Peritonitis (HP:0002586)1.81188835
140Cerebral palsy (HP:0100021)1.80820649
141Vomiting (HP:0002013)1.80790644
142Coxa vara (HP:0002812)1.79755748
143Cerebral inclusion bodies (HP:0100314)1.79195336
144Neonatal hypoglycemia (HP:0001998)1.78954186
145Hyperinsulinemic hypoglycemia (HP:0000825)1.76774666
146Gonadotropin excess (HP:0000837)1.76642501
147Spontaneous hematomas (HP:0007420)1.76476535
148Increased serum ferritin (HP:0003281)1.76377642
149Secondary amenorrhea (HP:0000869)1.76299559
150Increased mean platelet volume (HP:0011877)1.75410670
151Conjunctival telangiectasia (HP:0000524)1.75031221
152Vertebral arch anomaly (HP:0008438)1.73840691
153Partial agenesis of the corpus callosum (HP:0001338)1.73098829
154Hyperaldosteronism (HP:0000859)1.73024583
155Flattened epiphyses (HP:0003071)1.70358981
156Sensorimotor neuropathy (HP:0007141)1.70300854
157Disproportionate tall stature (HP:0001519)1.67896305
158Abnormality of the acetabulum (HP:0003170)1.66237644
15911 pairs of ribs (HP:0000878)1.65515393
160Broad face (HP:0000283)1.64750526
161Purpura (HP:0000979)1.63114138
162Abnormality of the pulmonary veins (HP:0011718)1.62990269
163Precocious puberty (HP:0000826)1.62255258
164Supernumerary nipples (HP:0002558)1.60395153
165Abnormal foot bone ossification (HP:0010675)1.60091386
166Neurofibrillary tangles (HP:0002185)1.59952381
167Anteriorly placed anus (HP:0001545)1.59418475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.21292733
2BCKDK4.68831129
3PRPF4B4.33912229
4TRIB34.04257341
5TIE13.66587081
6SIK13.47651799
7PKN23.43918728
8KDR3.19449555
9SMG12.76095832
10FGFR42.67941888
11RIPK12.29042969
12TGFBR22.22149113
13INSRR2.11184206
14PTK61.89173243
15FLT31.88700516
16TAOK31.78667339
17MAP2K31.75169154
18NME21.50271667
19CAMK1D1.47916251
20MAP3K31.47178856
21TYK21.44356266
22TBK11.42964890
23EEF2K1.42304764
24MAPK111.39443390
25TGFBR11.32124763
26DDR21.29847272
27PDK21.28303258
28SCYL21.26997519
29KSR21.26575836
30MAP3K101.25185492
31EIF2AK11.20663613
32LATS21.18358951
33AKT31.15280637
34MAP3K111.11941705
35LATS11.08033031
36PIM21.05465573
37MAPK121.05204038
38EPHB11.03596227
39MST1R0.99017058
40PIK3CG0.96897010
41CDK60.96735969
42JAK20.95270966
43CDK70.92659214
44ARAF0.92515089
45NEK90.91659289
46NTRK10.90617819
47AKT20.88963103
48IRAK30.88434196
49ERBB40.87010596
50RPS6KB20.86509644
51CDC42BPA0.85179565
52PDK10.85122554
53PRKAA20.82466622
54CAMK1G0.82144634
55PAK40.81368373
56MTOR0.79054498
57PRKD30.78984344
58MAP3K20.78195244
59CDK120.76595663
60MELK0.76207615
61CDK40.76167359
62JAK10.76124789
63MAP3K80.76105519
64ICK0.74004747
65TYRO30.72193363
66PTK2B0.71502219
67BMX0.71065617
68PDGFRA0.70610928
69TAOK20.70556774
70CSK0.70085477
71LMTK20.68423405
72SIK20.68321101
73ABL20.65748040
74MAP3K140.65633427
75PTK20.64194399
76MAPK70.64190560
77JAK30.64067977
78MAP4K10.63296859
79STK30.62915813
80KIT0.61970321
81LRRK20.61958199
82RAF10.61748435
83GSK3A0.61472982
84EPHB20.61044492
85MAP3K130.60481105
86MAPK40.58416232
87GRK10.57864629
88DYRK1B0.57824555
89MAP3K10.54875070
90IKBKE0.53540076
91PRKG20.53246495
92PAK20.51764546
93MAPKAPK50.51146977
94ERBB20.51111237
95CDK90.51064115
96MET0.50769472
97MYLK0.49365906
98CSF1R0.49135630
99STK100.48504745
100MAP3K60.46827535
101MAP3K70.45624302
102CHUK0.45346193
103TTN0.45337709
104TESK10.45007036
105MAP2K40.44816914
106PRKD20.44255287
107MAP2K10.43267757
108RPS6KA20.42522234
109RPS6KA40.42057963
110BRAF0.41635071
111MAPKAPK30.41551664
112MAP2K20.41253450
113DAPK20.41171030
114FER0.40528218
115PRKACG0.40399573
116IGF1R0.40285626
117MAPK30.39964372
118PIM10.39746032
119NEK20.39474190
120ZAP700.39338065
121FGFR30.39145842
122PDPK10.37957822
123EGFR0.37400888
124BRD40.36794462
125PRKCZ0.35621408
126EPHA20.35385362
127MARK20.34964032
128MAP3K90.34330839
129BTK0.33754105
130MAP3K50.33606928
131GRK60.33461938
132PRKAA10.33379998
133MAPK150.33080865
134MAPK100.32552023
135RET0.32189889
136CDK80.31784980
137CDK10.31151160
138MAPK10.30792490
139RIPK40.30301567
140CLK10.30058761
141TTK0.29762281
142TESK20.29750106
143WNK40.29202103
144RPS6KA10.28401475
145CDK20.28154325
146CAMK40.28137248
147RPS6KL10.27652643
148RPS6KC10.27652643
149NEK10.26597227

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.04655214
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09284649
3Nitrogen metabolism_Homo sapiens_hsa009103.00579333
4Steroid hormone biosynthesis_Homo sapiens_hsa001403.00008037
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95158250
6Complement and coagulation cascades_Homo sapiens_hsa046102.91151184
7Arginine biosynthesis_Homo sapiens_hsa002202.81649645
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79194759
9Fatty acid degradation_Homo sapiens_hsa000712.76936354
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48683406
11Tryptophan metabolism_Homo sapiens_hsa003802.45464188
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45133515
13PPAR signaling pathway_Homo sapiens_hsa033202.39419631
14Fatty acid metabolism_Homo sapiens_hsa012122.32163062
15Other glycan degradation_Homo sapiens_hsa005112.24358480
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23321784
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11974107
18Staphylococcus aureus infection_Homo sapiens_hsa051502.11551442
19Caffeine metabolism_Homo sapiens_hsa002322.06774000
20Propanoate metabolism_Homo sapiens_hsa006402.04093493
21Peroxisome_Homo sapiens_hsa041461.91418165
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89816776
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77460056
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.75928283
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.68650748
26Chemical carcinogenesis_Homo sapiens_hsa052041.66882386
27beta-Alanine metabolism_Homo sapiens_hsa004101.63348835
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61599769
29Butanoate metabolism_Homo sapiens_hsa006501.59461858
30Histidine metabolism_Homo sapiens_hsa003401.56604876
31Tyrosine metabolism_Homo sapiens_hsa003501.55352774
32Selenocompound metabolism_Homo sapiens_hsa004501.50287614
33Pyruvate metabolism_Homo sapiens_hsa006201.43453566
34Retinol metabolism_Homo sapiens_hsa008301.42960471
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41964731
36* Bile secretion_Homo sapiens_hsa049761.38100755
37Phenylalanine metabolism_Homo sapiens_hsa003601.33590103
38Carbon metabolism_Homo sapiens_hsa012001.32258044
39Biosynthesis of amino acids_Homo sapiens_hsa012301.28378462
40Fatty acid biosynthesis_Homo sapiens_hsa000611.23863989
41Starch and sucrose metabolism_Homo sapiens_hsa005001.23592403
42* Fat digestion and absorption_Homo sapiens_hsa049751.23298989
43Fatty acid elongation_Homo sapiens_hsa000621.22818626
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21618467
45ABC transporters_Homo sapiens_hsa020101.17704507
46Folate biosynthesis_Homo sapiens_hsa007901.16231349
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12438901
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.11228898
49Steroid biosynthesis_Homo sapiens_hsa001001.08760262
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07566811
51Lysine degradation_Homo sapiens_hsa003101.07412275
52N-Glycan biosynthesis_Homo sapiens_hsa005100.98909593
53* Vitamin digestion and absorption_Homo sapiens_hsa049770.95071313
54Sulfur relay system_Homo sapiens_hsa041220.90896245
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89577515
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88873897
57One carbon pool by folate_Homo sapiens_hsa006700.87108944
58* Ovarian steroidogenesis_Homo sapiens_hsa049130.85040933
59Arginine and proline metabolism_Homo sapiens_hsa003300.84255882
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84191627
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81887478
62Glycerolipid metabolism_Homo sapiens_hsa005610.81506575
63Sulfur metabolism_Homo sapiens_hsa009200.81227071
64Vitamin B6 metabolism_Homo sapiens_hsa007500.77943284
65Pentose phosphate pathway_Homo sapiens_hsa000300.76717259
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76216574
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.60068570
68Glutathione metabolism_Homo sapiens_hsa004800.58731705
69Chronic myeloid leukemia_Homo sapiens_hsa052200.57556964
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.57074217
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.56129312
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55999116
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55809649
74Insulin resistance_Homo sapiens_hsa049310.54609542
75Non-small cell lung cancer_Homo sapiens_hsa052230.51949997
76Thyroid hormone synthesis_Homo sapiens_hsa049180.51035658
77Renin-angiotensin system_Homo sapiens_hsa046140.50846544
78Galactose metabolism_Homo sapiens_hsa000520.50062848
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47356978
80mTOR signaling pathway_Homo sapiens_hsa041500.47225637
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47148634
82Thyroid cancer_Homo sapiens_hsa052160.46576732
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44789214
84Sphingolipid metabolism_Homo sapiens_hsa006000.43607874
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41864488
86Acute myeloid leukemia_Homo sapiens_hsa052210.41144033
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40122464
88Metabolic pathways_Homo sapiens_hsa011000.37222411
89HIF-1 signaling pathway_Homo sapiens_hsa040660.36386523
90Prolactin signaling pathway_Homo sapiens_hsa049170.35927207
91Pancreatic cancer_Homo sapiens_hsa052120.33848412
92VEGF signaling pathway_Homo sapiens_hsa043700.33778394
93ErbB signaling pathway_Homo sapiens_hsa040120.32043478
94Prion diseases_Homo sapiens_hsa050200.31807598
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.30585377
96* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29944058
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29756057
98Endometrial cancer_Homo sapiens_hsa052130.29079071
99AMPK signaling pathway_Homo sapiens_hsa041520.22788340
100Fructose and mannose metabolism_Homo sapiens_hsa000510.21566946
101Malaria_Homo sapiens_hsa051440.18716916
102Linoleic acid metabolism_Homo sapiens_hsa005910.14246474
103Glucagon signaling pathway_Homo sapiens_hsa049220.12959953
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12952930
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.08022073
106ECM-receptor interaction_Homo sapiens_hsa045120.07424791
107Legionellosis_Homo sapiens_hsa051340.07218843
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05798208
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.05678745
110Lysosome_Homo sapiens_hsa041420.04915864
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03584433
112Amoebiasis_Homo sapiens_hsa051460.02451609
113Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0864612
114Small cell lung cancer_Homo sapiens_hsa05222-0.0669669
115Pertussis_Homo sapiens_hsa05133-0.0520436
116Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0517315
117Bladder cancer_Homo sapiens_hsa05219-0.0382287
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0347338
119African trypanosomiasis_Homo sapiens_hsa05143-0.0305563
120Protein digestion and absorption_Homo sapiens_hsa04974-0.0298483
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0275600
122Insulin signaling pathway_Homo sapiens_hsa04910-0.0128638

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