SCARF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.84026080
2collagen fibril organization (GO:0030199)6.09774815
3bone trabecula formation (GO:0060346)5.48677523
4chondrocyte proliferation (GO:0035988)5.36440400
5axon extension involved in axon guidance (GO:0048846)5.32648791
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.32648791
7endodermal cell differentiation (GO:0035987)5.00909506
8skin morphogenesis (GO:0043589)4.83101908
9sequestering of extracellular ligand from receptor (GO:0035581)4.62045548
10collagen metabolic process (GO:0032963)4.61186986
11collagen catabolic process (GO:0030574)4.54589293
12multicellular organismal macromolecule metabolic process (GO:0044259)4.35636623
13negative regulation of fatty acid transport (GO:2000192)4.23504866
14multicellular organismal catabolic process (GO:0044243)4.21171706
15outer ear morphogenesis (GO:0042473)4.16007794
16multicellular organismal metabolic process (GO:0044236)4.09776581
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.06472311
18metanephric mesenchyme development (GO:0072075)4.02614876
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.01523156
20basement membrane organization (GO:0071711)3.94922958
21virion attachment to host cell (GO:0019062)3.93599711
22adhesion of symbiont to host cell (GO:0044650)3.93599711
23extracellular matrix disassembly (GO:0022617)3.89057920
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.84030518
25kidney mesenchyme development (GO:0072074)3.82228587
26type B pancreatic cell proliferation (GO:0044342)3.81304438
27dermatan sulfate metabolic process (GO:0030205)3.74811089
28polarized epithelial cell differentiation (GO:0030859)3.69187202
29cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.64080381
30cell adhesion mediated by integrin (GO:0033627)3.62239075
31Golgi transport vesicle coating (GO:0048200)3.62213716
32COPI coating of Golgi vesicle (GO:0048205)3.62213716
33apoptotic cell clearance (GO:0043277)3.62120846
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.59618828
35craniofacial suture morphogenesis (GO:0097094)3.57415099
36mesenchymal-epithelial cell signaling (GO:0060638)3.55894516
37positive regulation of endothelial cell apoptotic process (GO:2000353)3.55520456
38adhesion of symbiont to host (GO:0044406)3.54970410
39protein retention in ER lumen (GO:0006621)3.54891296
40positive regulation of blood vessel endothelial cell migration (GO:0043536)3.54469565
41negative regulation of chondrocyte differentiation (GO:0032331)3.53615304
42vascular endothelial growth factor signaling pathway (GO:0038084)3.52413029
43dermatan sulfate biosynthetic process (GO:0030208)3.52089120
44plasma membrane repair (GO:0001778)3.50952038
45cell migration involved in heart development (GO:0060973)3.50171506
46wound healing, spreading of epidermal cells (GO:0035313)3.49814778
47adherens junction assembly (GO:0034333)3.47134316
48middle ear morphogenesis (GO:0042474)3.45676859
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.43208729
50negative regulation of smooth muscle cell migration (GO:0014912)3.42772008
51embryonic cranial skeleton morphogenesis (GO:0048701)3.41942528
52positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.37768100
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.36532898
54cochlea morphogenesis (GO:0090103)3.34943295
55hippo signaling (GO:0035329)3.32185513
56extracellular fibril organization (GO:0043206)3.31477255
57endocardial cushion development (GO:0003197)3.30488181
58cell proliferation involved in metanephros development (GO:0072203)3.29863986
59insulin-like growth factor receptor signaling pathway (GO:0048009)3.28510670
60chondroitin sulfate biosynthetic process (GO:0030206)3.26014142
61epithelial cell-cell adhesion (GO:0090136)3.24911681
62heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.20234206
63blood vessel maturation (GO:0001955)3.19651333
64peptidyl-proline hydroxylation (GO:0019511)3.15499836
65positive regulation of epithelial to mesenchymal transition (GO:0010718)3.15050824
66glomerular basement membrane development (GO:0032836)3.14520320
67cellular response to vitamin (GO:0071295)3.12659272
68positive regulation of mesenchymal cell proliferation (GO:0002053)3.12401958
69cell migration involved in sprouting angiogenesis (GO:0002042)3.09945147
70cell-substrate adherens junction assembly (GO:0007045)3.08624204
71focal adhesion assembly (GO:0048041)3.08624204
72extracellular matrix assembly (GO:0085029)3.08540304
73vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.07622212
74regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.05173012
75substrate-dependent cell migration (GO:0006929)3.04266231
76keratan sulfate catabolic process (GO:0042340)3.03679754
77retina vasculature morphogenesis in camera-type eye (GO:0061299)3.03653587
78negative regulation of cartilage development (GO:0061037)3.03638880
79stress fiber assembly (GO:0043149)3.03268701
80endothelial cell morphogenesis (GO:0001886)2.99044688
81regulation of heart morphogenesis (GO:2000826)2.97626017
82positive regulation of osteoblast proliferation (GO:0033690)2.96426479
83negative regulation of catenin import into nucleus (GO:0035414)2.95213928
84barbed-end actin filament capping (GO:0051016)2.94620633
85cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.93225882
86fibril organization (GO:0097435)2.92221748
87lymph vessel development (GO:0001945)2.90180641
88chondroitin sulfate catabolic process (GO:0030207)2.89188873
89extracellular matrix organization (GO:0030198)2.88542466
90cellular response to vitamin D (GO:0071305)2.88386321
91convergent extension (GO:0060026)2.87635237
92protein localization to endosome (GO:0036010)2.87321986
93extracellular structure organization (GO:0043062)2.87275970
94regulation of plasminogen activation (GO:0010755)2.86644328
95negative regulation of embryonic development (GO:0045992)2.85030933
96paraxial mesoderm development (GO:0048339)2.83999725
97chondrocyte development (GO:0002063)2.83642394
98muscle cell migration (GO:0014812)2.83434368
99wound healing, spreading of cells (GO:0044319)2.83085618
100pattern specification involved in kidney development (GO:0061004)2.82078686
101regulation of early endosome to late endosome transport (GO:2000641)2.81674297
102cellular response to amino acid stimulus (GO:0071230)2.81321434
103positive regulation of cartilage development (GO:0061036)2.81181898
104protein localization to cell surface (GO:0034394)2.81131097
105protein hydroxylation (GO:0018126)2.81039621
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80966855
107regulation of cartilage development (GO:0061035)2.80226749
108embryonic skeletal joint morphogenesis (GO:0060272)2.80153346
109regulation of mesenchymal cell proliferation (GO:0010464)2.80053382
110glial cell migration (GO:0008347)2.76460002
111trabecula formation (GO:0060343)2.76063073
112regulation of tight junction assembly (GO:2000810)2.75126353
113venous blood vessel morphogenesis (GO:0048845)2.74722245
114outflow tract septum morphogenesis (GO:0003148)2.74430999
115cell proliferation involved in kidney development (GO:0072111)2.73234902
116regulation of establishment of planar polarity (GO:0090175)2.72763392
117renal filtration (GO:0097205)2.72475184
118blood vessel endothelial cell migration (GO:0043534)2.72097190
119substrate adhesion-dependent cell spreading (GO:0034446)2.71753118
120cranial suture morphogenesis (GO:0060363)2.71509190
121establishment of apical/basal cell polarity (GO:0035089)2.71472077
122cell-substrate junction assembly (GO:0007044)2.70411761
123anatomical structure regression (GO:0060033)2.69648757
124mesenchyme morphogenesis (GO:0072132)2.67582721
125semaphorin-plexin signaling pathway (GO:0071526)2.67264046
126endochondral ossification (GO:0001958)2.66551723
127replacement ossification (GO:0036075)2.66551723
128mesenchyme development (GO:0060485)2.66337474
129heparan sulfate proteoglycan metabolic process (GO:0030201)2.66004230
130artery morphogenesis (GO:0048844)2.65666709
131mesenchymal cell proliferation (GO:0010463)2.65311528
132dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65024427
133tooth mineralization (GO:0034505)2.64847915
134regulation of extracellular matrix disassembly (GO:0010715)2.64434624
135organ induction (GO:0001759)2.63961627
136non-canonical Wnt signaling pathway (GO:0035567)2.63430914
137atrioventricular valve morphogenesis (GO:0003181)2.62659448
138actin filament depolymerization (GO:0030042)2.62641568
139regulation of mammary gland epithelial cell proliferation (GO:0033599)2.56954288
140endocardial cushion morphogenesis (GO:0003203)2.56723405
141positive regulation of smoothened signaling pathway (GO:0045880)2.55120332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.45647982
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.09595597
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.69401611
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.43531716
5CLOCK_20551151_ChIP-Seq_293T_Human3.21304299
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.97314528
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91168118
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.87341214
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.40787603
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39606565
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37697936
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32439149
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.31847867
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.25980298
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.24570841
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.22909160
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.04689161
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.99527418
19CJUN_26792858_Chip-Seq_BT549_Human1.96593256
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87393888
21BRD4_25478319_ChIP-Seq_HGPS_Human1.84711587
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78702827
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.78059805
24* TP53_20018659_ChIP-ChIP_R1E_Mouse1.77856059
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75720191
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.74444135
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69685190
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.68292270
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.65600453
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.62733381
31LXR_22292898_ChIP-Seq_THP-1_Human1.62073403
32SMC1_22415368_ChIP-Seq_MEFs_Mouse1.60097107
33* EED_16625203_ChIP-ChIP_MESCs_Mouse1.59697853
34RACK7_27058665_Chip-Seq_MCF-7_Human1.59165258
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59061881
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53447195
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53134241
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50536215
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47064889
40UBF1/2_26484160_Chip-Seq_HMECs_Human1.46966964
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46093648
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44684039
43ATF3_27146783_Chip-Seq_COLON_Human1.44266011
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43957000
45* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43336016
46* KDM2B_26808549_Chip-Seq_K562_Human1.42565079
47TP53_22127205_ChIP-Seq_IMR90_Human1.42115337
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41545137
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41444710
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41352141
51* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40919070
52* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40919070
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.39617223
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.38875244
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.38875244
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37736393
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37736393
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36073541
59KDM2B_26808549_Chip-Seq_DND41_Human1.35501374
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.32038983
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31504972
62VDR_21846776_ChIP-Seq_THP-1_Human1.30711882
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29181396
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27811685
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27486502
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27097051
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26973460
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26768421
69TCF7_22412390_ChIP-Seq_EML_Mouse1.26199745
70TP53_23651856_ChIP-Seq_MEFs_Mouse1.25530196
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24997704
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24017870
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.23915309
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23175036
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22409953
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.21601772
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21464718
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21179341
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21179341
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20788039
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20006368
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19804577
83* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19466356
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19260524
85* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18026315
86SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17306137
87ZNF263_19887448_ChIP-Seq_K562_Human1.17217513
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17128880
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15616291
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15277734
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13438315
92TP53_18474530_ChIP-ChIP_U2OS_Human1.12893056
93CTCF_27219007_Chip-Seq_Bcells_Human1.12397053
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12377485
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11791629
96* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10605429
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10418385
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10053682
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09810827
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.09810257
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08741535
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08229904
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08000112
104* RNF2_27304074_Chip-Seq_ESCs_Mouse1.07189219
105SOX2_20726797_ChIP-Seq_SW620_Human1.06034026
106* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05630918
107* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04693210
108P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03786432
109* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02511994
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02383550
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02218324
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01860867
113* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01612594
114* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01167160
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00812112
116* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00376864
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00029282
118SA1_22415368_ChIP-Seq_MEFs_Mouse0.99540619
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99480908
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99364286
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99336266
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98762651
123* EZH2_27304074_Chip-Seq_ESCs_Mouse0.98574922
124CREB1_26743006_Chip-Seq_LNCaP_Human0.98537473
125KLF5_25053715_ChIP-Seq_YYC3_Human0.97649426
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.96664677
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94860128
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94700526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.63358125
2MP0005275_abnormal_skin_tensile4.77233824
3MP0005503_abnormal_tendon_morphology4.64185038
4MP0003705_abnormal_hypodermis_morpholog4.15094197
5MP0003279_aneurysm3.36041058
6MP0001958_emphysema3.33287353
7MP0004272_abnormal_basement_membrane3.02147001
8MP0005623_abnormal_meninges_morphology2.86076889
9MP0010030_abnormal_orbit_morphology2.51325988
10MP0006054_spinal_hemorrhage2.50245419
11MP0005257_abnormal_intraocular_pressure2.40362461
12MP0005508_abnormal_skeleton_morphology2.13398731
13MP0009384_cardiac_valve_regurgitation2.10393926
14MP0004858_abnormal_nervous_system2.01877276
15MP0003566_abnormal_cell_adhesion2.01515635
16MP0003385_abnormal_body_wall1.97199268
17MP0009250_abnormal_appendicular_skeleto1.94369519
18MP0002060_abnormal_skin_morphology1.93318355
19MP0005171_absent_coat_pigmentation1.82493516
20MP0005023_abnormal_wound_healing1.77353271
21MP0003283_abnormal_digestive_organ1.74907151
22MP0000733_abnormal_muscle_development1.73536680
23MP0001542_abnormal_bone_strength1.71567751
24MP0010368_abnormal_lymphatic_system1.69501891
25MP0002896_abnormal_bone_mineralization1.68001577
26MP0002295_abnormal_pulmonary_circulatio1.62667724
27MP0003091_abnormal_cell_migration1.60180062
28MP0000534_abnormal_ureter_morphology1.58352798
29MP0002108_abnormal_muscle_morphology1.55452674
30MP0003942_abnormal_urinary_system1.54930447
31MP0009053_abnormal_anal_canal1.52572980
32MP0001243_abnormal_dermal_layer1.43269395
33MP0003115_abnormal_respiratory_system1.41847308
34MP0000428_abnormal_craniofacial_morphol1.41040213
35MP0000767_abnormal_smooth_muscle1.40891238
36MP0000537_abnormal_urethra_morphology1.39062586
37MP0002932_abnormal_joint_morphology1.35046514
38MP0002282_abnormal_trachea_morphology1.34794224
39MP0010352_gastrointestinal_tract_polyps1.34352427
40MP0001299_abnormal_eye_distance/1.32220774
41MP0002115_abnormal_skeleton_extremities1.28618127
42MP0000163_abnormal_cartilage_morphology1.24199201
43MP0005076_abnormal_cell_differentiation1.24079202
44MP0000049_abnormal_middle_ear1.24065250
45MP0002877_abnormal_melanocyte_morpholog1.23069157
46MP0002249_abnormal_larynx_morphology1.20398057
47MP0003755_abnormal_palate_morphology1.13777016
48MP0001879_abnormal_lymphatic_vessel1.12201779
49MP0005058_abnormal_lysosome_morphology1.12022748
50MP0005595_abnormal_vascular_smooth1.11398287
51MP0002254_reproductive_system_inflammat1.11283401
52MP0005390_skeleton_phenotype1.11017513
53MP0003122_maternal_imprinting1.10402762
54MP0003935_abnormal_craniofacial_develop1.08551942
55MP0004134_abnormal_chest_morphology1.08536637
56MP0000751_myopathy1.06979162
57MP0000013_abnormal_adipose_tissue1.05816600
58MP0002113_abnormal_skeleton_development1.05222647
59MP0001348_abnormal_lacrimal_gland1.05109856
60MP0003045_fibrosis1.03453359
61MP0001849_ear_inflammation1.01562805
62MP0002998_abnormal_bone_remodeling0.99755590
63MP0005409_darkened_coat_color0.99394805
64MP0002116_abnormal_craniofacial_bone0.97232244
65MP0000762_abnormal_tongue_morphology0.96829316
66MP0002168_other_aberrant_phenotype0.95017370
67MP0002109_abnormal_limb_morphology0.94452200
68MP0005367_renal/urinary_system_phenotyp0.94155475
69MP0000516_abnormal_urinary_system0.94155475
70MP0002233_abnormal_nose_morphology0.93590654
71MP0002089_abnormal_postnatal_growth/wei0.93403089
72MP0000432_abnormal_head_morphology0.91849743
73MP0002128_abnormal_blood_circulation0.91643309
74MP0003937_abnormal_limbs/digits/tail_de0.90560878
75MP0003950_abnormal_plasma_membrane0.90554309
76MP0004185_abnormal_adipocyte_glucose0.88899220
77MP0001614_abnormal_blood_vessel0.85483929
78MP0000750_abnormal_muscle_regeneration0.85088079
79MP0002933_joint_inflammation0.84270131
80MP0000003_abnormal_adipose_tissue0.83357204
81MP0002111_abnormal_tail_morphology0.83149700
82MP0002925_abnormal_cardiovascular_devel0.82535907
83MP0001175_abnormal_lung_morphology0.81263290
84MP0002234_abnormal_pharynx_morphology0.80277647
85MP0003941_abnormal_skin_development0.79598449
86MP0002697_abnormal_eye_size0.79511913
87MP0000462_abnormal_digestive_system0.78079776
88MP0009278_abnormal_bone_marrow0.77939522
89MP0003795_abnormal_bone_structure0.77685312
90MP0001270_distended_abdomen0.77534640
91MP0003123_paternal_imprinting0.76705299
92MP0000858_altered_metastatic_potential0.73856571
93MP0006138_congestive_heart_failure0.73854984
94MP0009840_abnormal_foam_cell0.73134101
95MP0003448_altered_tumor_morphology0.71927267
96MP0005197_abnormal_uvea_morphology0.70496829
97MP0004197_abnormal_fetal_growth/weight/0.69930107
98MP0002114_abnormal_axial_skeleton0.69864141
99MP0009780_abnormal_chondrocyte_physiolo0.67998017
100MP0002133_abnormal_respiratory_system0.67942007
101MP0005388_respiratory_system_phenotype0.67942007
102MP0000759_abnormal_skeletal_muscle0.66783732
103MP0001915_intracranial_hemorrhage0.66500175
104MP0002092_abnormal_eye_morphology0.65346593
105MP0005193_abnormal_anterior_eye0.62222490
106MP0002177_abnormal_outer_ear0.61791049
107MP0003172_abnormal_lysosome_physiology0.61407375
108MP0001177_atelectasis0.61178940
109MP0004087_abnormal_muscle_fiber0.60968722
110MP0003567_abnormal_fetal_cardiomyocyte0.60621901
111MP0003300_gastrointestinal_ulcer0.60344232
112MP0001533_abnormal_skeleton_physiology0.60231017
113MP0004510_myositis0.59089422
114MP0000681_abnormal_thyroid_gland0.57682772
115MP0000749_muscle_degeneration0.56860342
116MP0005375_adipose_tissue_phenotype0.55936165
117MP0005621_abnormal_cell_physiology0.54311471
118MP0000678_abnormal_parathyroid_gland0.54296386

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.23634307
2Premature rupture of membranes (HP:0001788)7.55043183
3Ankle contracture (HP:0006466)5.46856994
4Shallow orbits (HP:0000586)5.33959292
5Broad metatarsal (HP:0001783)4.83830946
6Atrophic scars (HP:0001075)4.68744540
7Aortic dissection (HP:0002647)4.56471341
8Peritonitis (HP:0002586)4.30242545
9Cerebral aneurysm (HP:0004944)4.22142023
10Bladder diverticulum (HP:0000015)4.20024873
11Soft skin (HP:0000977)4.12605990
12Fragile skin (HP:0001030)3.95640567
13Abnormality of dentin (HP:0010299)3.95505800
14Neonatal short-limb short stature (HP:0008921)3.74528567
15Cervical subluxation (HP:0003308)3.67178586
16Follicular hyperkeratosis (HP:0007502)3.64350500
17Type 1 muscle fiber predominance (HP:0003803)3.61668397
18Dilatation of the ascending aorta (HP:0005111)3.50601688
19Mitral valve prolapse (HP:0001634)3.48425049
20Blue sclerae (HP:0000592)3.35210302
21Genu recurvatum (HP:0002816)3.33947713
22Aortic aneurysm (HP:0004942)3.31852079
23Wormian bones (HP:0002645)3.30793524
24Spinal rigidity (HP:0003306)3.22010809
25Vertebral compression fractures (HP:0002953)3.19292870
26Biconcave vertebral bodies (HP:0004586)3.18341715
27Wrist flexion contracture (HP:0001239)3.08225354
28Bowel diverticulosis (HP:0005222)3.05484924
29Increased connective tissue (HP:0009025)3.02612820
30Slender build (HP:0001533)2.91353672
31Hyperextensible skin (HP:0000974)2.72359759
32Increased variability in muscle fiber diameter (HP:0003557)2.67897813
33Mildly elevated creatine phosphokinase (HP:0008180)2.66578380
34Short 4th metacarpal (HP:0010044)2.62983473
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62983473
36Wide anterior fontanel (HP:0000260)2.57706198
37* Deviation of the hallux (HP:0010051)2.47931722
38Abnormal delivery (HP:0001787)2.46690318
39Coronal craniosynostosis (HP:0004440)2.44600269
40Joint laxity (HP:0001388)2.43317677
41Abnormality of the acetabulum (HP:0003170)2.40561283
42Aneurysm (HP:0002617)2.40357380
43Buphthalmos (HP:0000557)2.40157066
44Joint stiffness (HP:0001387)2.39530369
45Achilles tendon contracture (HP:0001771)2.39206484
46Vascular tortuosity (HP:0004948)2.38141844
47* Hallux valgus (HP:0001822)2.36085621
48Thin bony cortex (HP:0002753)2.32648994
49Osteolytic defects of the hand bones (HP:0009699)2.31918051
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.31918051
51Obstructive sleep apnea (HP:0002870)2.31667338
52Abnormality of skeletal muscle fiber size (HP:0012084)2.29926560
53Mesomelia (HP:0003027)2.28469891
54Nonimmune hydrops fetalis (HP:0001790)2.26689928
55Asymmetry of the thorax (HP:0001555)2.24244895
56Ectopia lentis (HP:0001083)2.22568687
57Abnormality of the peritoneum (HP:0002585)2.20928192
58Overgrowth (HP:0001548)2.20240223
59Abnormality of the 4th metacarpal (HP:0010012)2.19905164
60Mitral regurgitation (HP:0001653)2.19403457
61Infantile muscular hypotonia (HP:0008947)2.19206367
62Renal duplication (HP:0000075)2.15018819
63Tibial bowing (HP:0002982)2.12649117
64Broad ribs (HP:0000885)2.12516707
65* Elbow flexion contracture (HP:0002987)2.12195521
66Turricephaly (HP:0000262)2.10819355
67Abnormality of the Achilles tendon (HP:0005109)2.10183318
68* Disproportionate tall stature (HP:0001519)2.06877029
69Premature skin wrinkling (HP:0100678)2.06272403
70Osteoarthritis (HP:0002758)2.05577316
71Aortic valve stenosis (HP:0001650)2.03770180
72Lymphangioma (HP:0100764)2.03607253
73Breech presentation (HP:0001623)2.03440191
74Hand muscle atrophy (HP:0009130)2.03098868
75* Camptodactyly of toe (HP:0001836)2.02385476
76Arterial tortuosity (HP:0005116)2.02253626
77Distal lower limb amyotrophy (HP:0008944)1.99145916
78Abnormality of the distal phalanges of the toes (HP:0010182)1.98889168
79Broad long bones (HP:0005622)1.98531159
80Broad face (HP:0000283)1.98233752
81Radial bowing (HP:0002986)1.97652980
82Bell-shaped thorax (HP:0001591)1.95682808
83Venous abnormality (HP:0002624)1.95247730
84Striae distensae (HP:0001065)1.94650183
85Morphological abnormality of the middle ear (HP:0008609)1.94351131
86Abnormality of the phalanges of the hallux (HP:0010057)1.93083880
87Flat cornea (HP:0007720)1.92757185
88Hypoplasia of the iris (HP:0007676)1.91626103
89Syringomyelia (HP:0003396)1.91274844
90Spinal cord lesions (HP:0100561)1.91274844
91Osteopenia (HP:0000938)1.88478303
92Venous insufficiency (HP:0005293)1.88093822
93Spondylolisthesis (HP:0003302)1.87564637
94Short nail (HP:0001799)1.86977753
95Hypoventilation (HP:0002791)1.86697448
96Congenital glaucoma (HP:0001087)1.86443926
97Natal tooth (HP:0000695)1.84635427
98Renovascular hypertension (HP:0100817)1.84288652
99Increased density of long bones (HP:0006392)1.81642486
100Scapular winging (HP:0003691)1.81179288
101Upper limb amyotrophy (HP:0009129)1.78821563
102Distal upper limb amyotrophy (HP:0007149)1.78821563
103Delayed cranial suture closure (HP:0000270)1.78617309
104Mitral stenosis (HP:0001718)1.77221308
105Atelectasis (HP:0100750)1.76600829
106Coxa vara (HP:0002812)1.76233920
107Inguinal hernia (HP:0000023)1.75396261
108Abnormality of skull ossification (HP:0002703)1.75331394
109Mild short stature (HP:0003502)1.72792959
110Hip contracture (HP:0003273)1.72533998
111Aortic regurgitation (HP:0001659)1.72282841
112Enlarged penis (HP:0000040)1.71908392
113Platyspondyly (HP:0000926)1.71617377
114* Ulnar bowing (HP:0003031)1.71386175
115Limb-girdle muscle weakness (HP:0003325)1.70909835
116Broad toe (HP:0001837)1.70572117
117Generalized amyotrophy (HP:0003700)1.69974280
118Ulnar deviation of the wrist (HP:0003049)1.69787230
119Round ear (HP:0100830)1.69138719
120Hyperacusis (HP:0010780)1.68545232
121Short clavicles (HP:0000894)1.68543496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.15040318
2DDR24.61428336
3TTN3.85565505
4PKN23.68409674
5PDGFRA3.62592161
6ERN12.95738074
7LATS12.88349666
8EPHB22.67394527
9LATS22.63611931
10SIK12.52668748
11RIPK12.49830640
12SMG12.10925228
13PTK62.02430295
14MAP3K102.01017196
15EEF2K1.93810207
16BMX1.92270727
17PAK21.89391032
18TGFBR21.77994188
19PAK41.76868885
20PTK21.69250646
21LRRK21.67972517
22EPHA31.46913461
23PRPF4B1.41760040
24PDGFRB1.37693863
25STK381.36781783
26FER1.36134060
27DMPK1.35919040
28MET1.31613119
29ILK1.29335352
30FGFR21.27937160
31MAP3K61.18741497
32TAOK21.16403044
33MTOR1.15077007
34FGFR11.12488958
35ERBB41.12480175
36STK31.12231904
37RPS6KA41.11954689
38PTK2B1.07708461
39ICK1.06787739
40PRKD21.05648989
41AKT31.03750687
42IRAK31.03211834
43EPHB11.01551083
44TRPM70.95926462
45PAK30.94908446
46TIE10.94047486
47ROCK10.93061570
48PIK3CG0.89670939
49FGFR40.83465139
50MOS0.82933246
51PRKD30.82722405
52TGFBR10.82276000
53MYLK0.80902208
54PRKCH0.77720948
55PRKD10.74273860
56CAMK1D0.73304850
57STK38L0.73155578
58MST1R0.72361268
59ROCK20.70033707
60RET0.69741172
61EPHA20.64495450
62MAPK70.63735036
63NEK90.63263166
64MAP2K10.62189190
65DYRK1B0.61188319
66NTRK10.61167634
67MAP3K30.60964502
68TESK10.60961160
69CDK80.59897388
70FLT30.57629070
71MAP2K30.56008218
72CDK60.55334359
73KSR20.54506978
74PDPK10.54454422
75MAP3K110.54130205
76INSRR0.53983091
77ARAF0.53703124
78CAMK1G0.53361869
79MAP3K70.53044709
80LIMK10.51394144
81RPS6KA20.51173979
82CDK70.50024857
83ABL20.49034175
84MAP3K80.48074645
85INSR0.47880998
86GRK70.47612272
87CDC42BPA0.47010115
88SCYL20.46710356
89CDK120.46535768
90DAPK30.46523081
91MAPKAPK30.46339192
92RPS6KL10.45801021
93RPS6KC10.45801021
94HIPK20.45642092
95PAK10.44992010
96CAMKK10.44786878
97ZAP700.44262414
98TYRO30.42178635
99WNK10.42111244
100SRC0.42095178
101RPS6KA60.41739868
102MARK20.40973147
103GSK3A0.40094756
104MAP2K20.39629892
105MAPK150.38433279
106PAK60.38376124
107ERBB20.37944005
108CLK10.37909450
109KDR0.37177880
110STK100.35924797
111CDK90.35517512
112BRAF0.35148621
113MELK0.34778418
114KIT0.34734971
115JAK10.34235159
116MAPKAPK20.33723089
117LMTK20.32703631
118PIM20.32587654
119MAP3K130.32179460
120CDK11A0.30721239
121MAPK110.30200740
122NME20.29143962
123CDK150.28748939
124MAPK10.28139637
125TAOK10.27668275
126PRKG20.27270937
127NEK20.25541780
128ADRBK10.25265012
129PIK3CA0.22275005

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.66486495
2Focal adhesion_Homo sapiens_hsa045103.25524976
3Protein digestion and absorption_Homo sapiens_hsa049742.91601388
4Proteoglycans in cancer_Homo sapiens_hsa052052.48251992
5Basal cell carcinoma_Homo sapiens_hsa052172.45630315
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.39350777
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.36603034
8Amoebiasis_Homo sapiens_hsa051462.36402194
9Bladder cancer_Homo sapiens_hsa052192.32696214
10Adherens junction_Homo sapiens_hsa045202.05652612
11Hippo signaling pathway_Homo sapiens_hsa043902.04966483
12Small cell lung cancer_Homo sapiens_hsa052222.03404289
13Hedgehog signaling pathway_Homo sapiens_hsa043401.98195279
14Other glycan degradation_Homo sapiens_hsa005111.94634011
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88753037
16TGF-beta signaling pathway_Homo sapiens_hsa043501.83899021
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.82943363
18Dilated cardiomyopathy_Homo sapiens_hsa054141.75188015
19Chronic myeloid leukemia_Homo sapiens_hsa052201.72861862
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72332764
21MicroRNAs in cancer_Homo sapiens_hsa052061.69055212
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.66287293
23Malaria_Homo sapiens_hsa051441.57329742
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50264620
25Melanoma_Homo sapiens_hsa052181.47318684
26Prostate cancer_Homo sapiens_hsa052151.29974629
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29635887
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28408871
29Pathways in cancer_Homo sapiens_hsa052001.24077936
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23243128
31Axon guidance_Homo sapiens_hsa043601.21658659
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.20200709
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.19933824
34Glioma_Homo sapiens_hsa052141.18785792
35Notch signaling pathway_Homo sapiens_hsa043301.17478338
36Melanogenesis_Homo sapiens_hsa049161.10539517
37Pancreatic cancer_Homo sapiens_hsa052121.10014268
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09923581
39Rap1 signaling pathway_Homo sapiens_hsa040151.08920468
40Wnt signaling pathway_Homo sapiens_hsa043101.08761127
41Platelet activation_Homo sapiens_hsa046111.07389758
42Tight junction_Homo sapiens_hsa045301.05611721
43HTLV-I infection_Homo sapiens_hsa051661.01900813
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.01785334
45Vibrio cholerae infection_Homo sapiens_hsa051101.00974982
46Toxoplasmosis_Homo sapiens_hsa051450.97717049
47Viral myocarditis_Homo sapiens_hsa054160.94161536
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93547317
49p53 signaling pathway_Homo sapiens_hsa041150.90643238
50Estrogen signaling pathway_Homo sapiens_hsa049150.89852967
51TNF signaling pathway_Homo sapiens_hsa046680.89611967
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88016183
53Renal cell carcinoma_Homo sapiens_hsa052110.86933544
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86078997
55mTOR signaling pathway_Homo sapiens_hsa041500.84690864
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82589349
57Insulin resistance_Homo sapiens_hsa049310.82339965
58Endometrial cancer_Homo sapiens_hsa052130.79476300
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78238415
60Colorectal cancer_Homo sapiens_hsa052100.77607377
61Sulfur relay system_Homo sapiens_hsa041220.73105254
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72009616
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.71036881
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68580997
65Lysosome_Homo sapiens_hsa041420.68467031
66VEGF signaling pathway_Homo sapiens_hsa043700.67177530
67Lysine degradation_Homo sapiens_hsa003100.67137576
68Shigellosis_Homo sapiens_hsa051310.66873104
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.66738302
70Galactose metabolism_Homo sapiens_hsa000520.65846300
71Non-small cell lung cancer_Homo sapiens_hsa052230.65480167
72ErbB signaling pathway_Homo sapiens_hsa040120.65121334
73Gap junction_Homo sapiens_hsa045400.63583943
74Phagosome_Homo sapiens_hsa041450.62891298
75Cocaine addiction_Homo sapiens_hsa050300.61888541
76Renin-angiotensin system_Homo sapiens_hsa046140.61254101
77HIF-1 signaling pathway_Homo sapiens_hsa040660.61030095
78Viral carcinogenesis_Homo sapiens_hsa052030.60592430
79Choline metabolism in cancer_Homo sapiens_hsa052310.59553680
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.58539553
81GnRH signaling pathway_Homo sapiens_hsa049120.57586364
82Apoptosis_Homo sapiens_hsa042100.57575812
83AMPK signaling pathway_Homo sapiens_hsa041520.57031977
84Prion diseases_Homo sapiens_hsa050200.56690357
85Endocytosis_Homo sapiens_hsa041440.56004613
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55912659
87FoxO signaling pathway_Homo sapiens_hsa040680.54345225
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.53810819
89Thyroid hormone synthesis_Homo sapiens_hsa049180.53677720
90N-Glycan biosynthesis_Homo sapiens_hsa005100.52845371
91Hepatitis B_Homo sapiens_hsa051610.52512713
92Salmonella infection_Homo sapiens_hsa051320.52400871
93Caffeine metabolism_Homo sapiens_hsa002320.52301373
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.51975800
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.51872377
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50613568
97Insulin signaling pathway_Homo sapiens_hsa049100.50531979
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50236428
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49713162
100Ovarian steroidogenesis_Homo sapiens_hsa049130.49133480
101Ras signaling pathway_Homo sapiens_hsa040140.48621390
102Acute myeloid leukemia_Homo sapiens_hsa052210.48609408
103Pentose phosphate pathway_Homo sapiens_hsa000300.48472975
104Complement and coagulation cascades_Homo sapiens_hsa046100.48146175
105Thyroid cancer_Homo sapiens_hsa052160.47579311
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46470178
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45066878
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43011123
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42282175
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41019966
111Osteoclast differentiation_Homo sapiens_hsa043800.38660336
112Inositol phosphate metabolism_Homo sapiens_hsa005620.38571745
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38422067
114MAPK signaling pathway_Homo sapiens_hsa040100.38255659
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35950330
116Prolactin signaling pathway_Homo sapiens_hsa049170.32756185

Most similar genes based on co-expression Upload to Enrichr

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