ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	5.57269395
2	indolalkylamine metabolic process (GO:0006586)	4.70729231
3	tryptophan catabolic process (GO:0006569)	4.68605550
4	indole-containing compound catabolic process (GO:0042436)	4.68605550
5	indolalkylamine catabolic process (GO:0046218)	4.68605550
6	neural tube formation (GO:0001841)	4.58970495
7	tachykinin receptor signaling pathway (GO:0007217)	4.53258657
8	cilium or flagellum-dependent cell motility (GO:0001539)	4.28350345
9	kynurenine metabolic process (GO:0070189)	4.19842091
10	tryptophan metabolic process (GO:0006568)	4.15582855
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.11228158
12	establishment of protein localization to Golgi (GO:0072600)	3.98521897
13	fucose catabolic process (GO:0019317)	3.92380906
14	L-fucose metabolic process (GO:0042354)	3.92380906
15	L-fucose catabolic process (GO:0042355)	3.92380906
16	detection of light stimulus involved in visual perception (GO:0050908)	3.76967358
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.76967358
18	signal peptide processing (GO:0006465)	3.69065661
19	protein K48-linked deubiquitination (GO:0071108)	3.68546268
20	behavioral response to nicotine (GO:0035095)	3.68025411
21	regulation of memory T cell differentiation (GO:0043380)	3.50726981
22	response to pheromone (GO:0019236)	3.49514082
23	negative regulation of mast cell activation (GO:0033004)	3.48758394
24	regulation of B cell receptor signaling pathway (GO:0050855)	3.43074333
25	photoreceptor cell maintenance (GO:0045494)	3.37147738
26	protein K63-linked deubiquitination (GO:0070536)	3.36550425
27	regulation of hippo signaling (GO:0035330)	3.27133941
28	monoubiquitinated protein deubiquitination (GO:0035520)	3.23752420
29	regulation of establishment of cell polarity (GO:2000114)	3.22209424
30	indole-containing compound metabolic process (GO:0042430)	3.19197645
31	DNA methylation involved in gamete generation (GO:0043046)	3.17837887
32	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.14557552
33	behavioral response to ethanol (GO:0048149)	3.11020216
34	piRNA metabolic process (GO:0034587)	3.09637869
35	protein targeting to Golgi (GO:0000042)	3.04475545
36	reflex (GO:0060004)	3.03223549
37	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.99844458
38	NAD biosynthetic process (GO:0009435)	2.97597053
39	cellular ketone body metabolic process (GO:0046950)	2.96700430
40	thyroid hormone metabolic process (GO:0042403)	2.92662438
41	benzene-containing compound metabolic process (GO:0042537)	2.91317758
42	retinal cone cell development (GO:0046549)	2.89502529
43	amine catabolic process (GO:0009310)	2.89381861
44	cellular biogenic amine catabolic process (GO:0042402)	2.89381861
45	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.89334262
46	histone H3-K9 methylation (GO:0051567)	2.86572027
47	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.86557878
48	auditory receptor cell stereocilium organization (GO:0060088)	2.86263376
49	DNA deamination (GO:0045006)	2.85628383
50	DNA double-strand break processing (GO:0000729)	2.84690102
51	activated T cell proliferation (GO:0050798)	2.81467049
52	lipid translocation (GO:0034204)	2.80068381
53	phospholipid translocation (GO:0045332)	2.80068381
54	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.79882377
55	axoneme assembly (GO:0035082)	2.79658135
56	cellular response to sterol (GO:0036315)	2.78510362
57	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.77900955
58	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.75104758
59	positive regulation of developmental pigmentation (GO:0048087)	2.72439117
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72422900
61	adaptation of signaling pathway (GO:0023058)	2.71872452
62	centriole replication (GO:0007099)	2.70278085
63	ketone body metabolic process (GO:1902224)	2.67025764
64	sex differentiation (GO:0007548)	2.66729330
65	regulation of action potential (GO:0098900)	2.64969646
66	gamma-aminobutyric acid transport (GO:0015812)	2.62829505
67	neuronal action potential (GO:0019228)	2.60245536
68	serotonin receptor signaling pathway (GO:0007210)	2.59110575
69	positive regulation of granulocyte differentiation (GO:0030854)	2.59086830
70	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.57587106
71	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.57587106
72	regulation of translation, ncRNA-mediated (GO:0045974)	2.57587106
73	dopamine transport (GO:0015872)	2.54648118
74	interferon-gamma production (GO:0032609)	2.54382597
75	reciprocal DNA recombination (GO:0035825)	2.53053707
76	reciprocal meiotic recombination (GO:0007131)	2.53053707
77	gene silencing by RNA (GO:0031047)	2.52454138
78	double-strand break repair via homologous recombination (GO:0000724)	2.52450750
79	rhodopsin mediated signaling pathway (GO:0016056)	2.52098985
80	photoreceptor cell development (GO:0042461)	2.51982915
81	cellular response to interleukin-15 (GO:0071350)	2.50835649
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.49121153
83	recombinational repair (GO:0000725)	2.48878132
84	serotonin metabolic process (GO:0042428)	2.48802714
85	startle response (GO:0001964)	2.48602518
86	histone H3-K9 modification (GO:0061647)	2.47993883
87	regulation of MHC class I biosynthetic process (GO:0045343)	2.47553654
88	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.46339194
89	amino acid salvage (GO:0043102)	2.45991130
90	L-methionine salvage (GO:0071267)	2.45991130
91	L-methionine biosynthetic process (GO:0071265)	2.45991130
92	sphingoid metabolic process (GO:0046519)	2.45969164
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.45676258
94	embryonic epithelial tube formation (GO:0001838)	2.45037013
95	protein localization to Golgi apparatus (GO:0034067)	2.45029503
96	regulation of sarcomere organization (GO:0060297)	2.44695335
97	primary amino compound metabolic process (GO:1901160)	2.43401811
98	multicellular organism reproduction (GO:0032504)	2.42283872
99	aromatic amino acid family catabolic process (GO:0009074)	2.41446265
100	killing of cells of other organism (GO:0031640)	2.40969862

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.63305953
2	VDR_22108803_ChIP-Seq_LS180_Human	3.41834539
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39620990
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.18408066
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72881692
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.66069140
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56349151
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54333121
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.45656439
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.35378061
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34545520
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.30247920
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.25348918
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.21656779
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.14120458
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.13105732
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.07536295
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.01728130
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.97384324
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.93714175
21	P300_19829295_ChIP-Seq_ESCs_Human	1.91965747
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.91665722
23	FUS_26573619_Chip-Seq_HEK293_Human	1.90266395
24	STAT3_23295773_ChIP-Seq_U87_Human	1.86732771
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.80731048
26	EWS_26573619_Chip-Seq_HEK293_Human	1.80446614
27	TCF4_23295773_ChIP-Seq_U87_Human	1.69896426
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.67310495
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67310495
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65763882
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64695091
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60716866
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.57210997
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54876759
35	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.53975609
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.53499631
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52526619
38	AR_25329375_ChIP-Seq_VCAP_Human	1.50173037
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48801178
40	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.48032620
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47947915
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47444020
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46788358
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.43759216
45	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.43517873
46	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.38801341
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37011859
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.34989005
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34812532
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.34182742
51	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.33543772
52	DROSHA_22980978_ChIP-Seq_HELA_Human	1.32189106
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31727243
54	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31665981
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30848225
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28878335
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28878335
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28416473
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.28343110
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23029649
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22988913
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21869490
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21869490
64	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.20921287
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20870180
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19537016
67	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.18798964
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16777220
69	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15967840
70	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.15731279
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.15529931
72	TP53_16413492_ChIP-PET_HCT116_Human	1.15353352
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13313603
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12876296
75	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.11817683
76	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11626212
77	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10773847
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10154939
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10069029
80	GATA3_26560356_Chip-Seq_TH2_Human	1.09873277
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09742955
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09742955
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09436824
84	KDM2B_26808549_Chip-Seq_REH_Human	1.08858432
85	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07835408
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07619371
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07122489
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06292076
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03913377
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01889696
91	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.01707261
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01381383
93	NCOR_22424771_ChIP-Seq_293T_Human	1.01213780
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00891834
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99480308
96	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.99085071
97	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.98829513
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98657479
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98013656
100	RUNX_20019798_ChIP-Seq_JUKART_Human	0.95730049

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	2.83535298
2	MP0003195_calcinosis	2.83220342
3	MP0000569_abnormal_digit_pigmentation	2.73526978
4	MP0000372_irregular_coat_pigmentation	2.60010634
5	MP0005551_abnormal_eye_electrophysiolog	2.53246427
6	MP0008877_abnormal_DNA_methylation	2.44316368
7	MP0001501_abnormal_sleep_pattern	2.32980888
8	MP0004043_abnormal_pH_regulation	2.29981086
9	MP0001968_abnormal_touch/_nociception	2.28103221
10	MP0003646_muscle_fatigue	2.14458477
11	MP0005310_abnormal_salivary_gland	2.12404483
12	MP0002138_abnormal_hepatobiliary_system	2.12271472
13	MP0001986_abnormal_taste_sensitivity	1.97304546
14	MP0003136_yellow_coat_color	1.97280012
15	MP0003252_abnormal_bile_duct	1.95854401
16	MP0002102_abnormal_ear_morphology	1.92861637
17	MP0005253_abnormal_eye_physiology	1.90563598
18	MP0002736_abnormal_nociception_after	1.89114986
19	MP0002876_abnormal_thyroid_physiology	1.83005672
20	MP0009046_muscle_twitch	1.81530317
21	MP0006276_abnormal_autonomic_nervous	1.78195548
22	MP0009745_abnormal_behavioral_response	1.67079928
23	MP0005646_abnormal_pituitary_gland	1.62723426
24	MP0006072_abnormal_retinal_apoptosis	1.61313428
25	MP0010386_abnormal_urinary_bladder	1.60835687
26	MP0000427_abnormal_hair_cycle	1.59555764
27	MP0003045_fibrosis	1.55898788
28	MP0002928_abnormal_bile_duct	1.53853006
29	MP0003787_abnormal_imprinting	1.52277610
30	MP0005670_abnormal_white_adipose	1.49942044
31	MP0005645_abnormal_hypothalamus_physiol	1.49599608
32	MP0001984_abnormal_olfaction	1.49537305
33	MP0005075_abnormal_melanosome_morpholog	1.45539033
34	MP0004147_increased_porphyrin_level	1.45044675
35	MP0008995_early_reproductive_senescence	1.43879781
36	MP0004381_abnormal_hair_follicle	1.39436072
37	MP0008872_abnormal_physiological_respon	1.37721131
38	MP0002837_dystrophic_cardiac_calcinosis	1.36827516
39	MP0001486_abnormal_startle_reflex	1.36682553
40	MP0002638_abnormal_pupillary_reflex	1.35849750
41	MP0008875_abnormal_xenobiotic_pharmacok	1.32259178
42	MP0005171_absent_coat_pigmentation	1.31278311
43	MP0005647_abnormal_sex_gland	1.26119761
44	MP0000383_abnormal_hair_follicle	1.25449709
45	MP0005174_abnormal_tail_pigmentation	1.24932924
46	MP0001764_abnormal_homeostasis	1.24710022
47	MP0008961_abnormal_basal_metabolism	1.19127334
48	MP0004142_abnormal_muscle_tone	1.18978629
49	MP0003763_abnormal_thymus_physiology	1.18484664
50	MP0002272_abnormal_nervous_system	1.12689816
51	MP0003183_abnormal_peptide_metabolism	1.11893745
52	MP0003724_increased_susceptibility_to	1.11267553
53	MP0005085_abnormal_gallbladder_physiolo	1.11056936
54	MP0005410_abnormal_fertilization	1.10153930
55	MP0004145_abnormal_muscle_electrophysio	1.07140908
56	MP0001970_abnormal_pain_threshold	1.06996995
57	MP0002009_preneoplasia	1.06656990
58	MP0003880_abnormal_central_pattern	1.06524993
59	MP0008058_abnormal_DNA_repair	1.06378836
60	MP0000631_abnormal_neuroendocrine_gland	1.05011672
61	MP0001800_abnormal_humoral_immune	1.03964712
62	MP0001485_abnormal_pinna_reflex	1.03882681
63	MP0002735_abnormal_chemical_nociception	1.01302386
64	MP0000685_abnormal_immune_system	1.01036642
65	MP0005386_behavior/neurological_phenoty	0.98592690
66	MP0004924_abnormal_behavior	0.98592690
67	MP0000230_abnormal_systemic_arterial	0.97604858
68	MP0002064_seizures	0.96380103
69	MP0005389_reproductive_system_phenotype	0.95494304
70	MP0003698_abnormal_male_reproductive	0.93759150
71	MP0002067_abnormal_sensory_capabilities	0.92987433
72	MP0002168_other_aberrant_phenotype	0.92860215
73	MP0002229_neurodegeneration	0.92704769
74	MP0002572_abnormal_emotion/affect_behav	0.89890109
75	MP0002733_abnormal_thermal_nociception	0.89763947
76	MP0001919_abnormal_reproductive_system	0.88503643
77	MP0003950_abnormal_plasma_membrane	0.87529217
78	MP0001929_abnormal_gametogenesis	0.86570911
79	MP0000371_diluted_coat_color	0.86229665
80	MP0002234_abnormal_pharynx_morphology	0.85186911
81	MP0005266_abnormal_metabolism	0.83982374
82	MP0000015_abnormal_ear_pigmentation	0.83608675
83	MP0005167_abnormal_blood-brain_barrier	0.82906428
84	MP0002396_abnormal_hematopoietic_system	0.81797231
85	MP0003011_delayed_dark_adaptation	0.81776734
86	MP0005671_abnormal_response_to	0.80852028
87	MP0006292_abnormal_olfactory_placode	0.79909592
88	MP0003878_abnormal_ear_physiology	0.78572097
89	MP0005377_hearing/vestibular/ear_phenot	0.78572097
90	MP0004130_abnormal_muscle_cell	0.76740657
91	MP0003943_abnormal_hepatobiliary_system	0.76668802
92	MP0002723_abnormal_immune_serum	0.73690451
93	MP0002095_abnormal_skin_pigmentation	0.73680045
94	MP0004742_abnormal_vestibular_system	0.73541332
95	MP0005083_abnormal_biliary_tract	0.73532215
96	MP0003718_maternal_effect	0.73009448
97	MP0010329_abnormal_lipoprotein_level	0.72319307
98	MP0001873_stomach_inflammation	0.72128131
99	MP0000653_abnormal_sex_gland	0.71095370
100	MP0003635_abnormal_synaptic_transmissio	0.70388422

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.52281549
2	Gaze-evoked nystagmus (HP:0000640)	4.06426298
3	Congenital stationary night blindness (HP:0007642)	3.95523207
4	Genetic anticipation (HP:0003743)	3.89118039
5	Pancreatic fibrosis (HP:0100732)	3.88435238
6	Attenuation of retinal blood vessels (HP:0007843)	3.87727868
7	True hermaphroditism (HP:0010459)	3.80314252
8	Abnormality of the renal cortex (HP:0011035)	3.59473813
9	Hyperventilation (HP:0002883)	3.48177954
10	Progressive cerebellar ataxia (HP:0002073)	3.36368259
11	Nephronophthisis (HP:0000090)	3.35264579
12	Chronic hepatic failure (HP:0100626)	3.33142796
13	Abnormality of midbrain morphology (HP:0002418)	3.28435201
14	Molar tooth sign on MRI (HP:0002419)	3.28435201
15	Abnormality of the renal medulla (HP:0100957)	3.14471798
16	Abolished electroretinogram (ERG) (HP:0000550)	3.06424802
17	Cystic liver disease (HP:0006706)	2.97722097
18	Clumsiness (HP:0002312)	2.95682769
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.86641004
20	Absent speech (HP:0001344)	2.78695812
21	Bony spicule pigmentary retinopathy (HP:0007737)	2.75232590
22	Medial flaring of the eyebrow (HP:0010747)	2.75163639
23	Abnormal biliary tract physiology (HP:0012439)	2.66010180
24	Bile duct proliferation (HP:0001408)	2.66010180
25	Renal cortical cysts (HP:0000803)	2.57008446
26	Stomach cancer (HP:0012126)	2.57003627
27	Type II lissencephaly (HP:0007260)	2.55159511
28	Protruding tongue (HP:0010808)	2.53489132
29	Congenital sensorineural hearing impairment (HP:0008527)	2.53369748
30	Tubular atrophy (HP:0000092)	2.51387390
31	Febrile seizures (HP:0002373)	2.50746624
32	Prostate neoplasm (HP:0100787)	2.50099854
33	Progressive inability to walk (HP:0002505)	2.49998843
34	Fair hair (HP:0002286)	2.48682181
35	Polydipsia (HP:0001959)	2.40556096
36	Abnormal drinking behavior (HP:0030082)	2.40556096
37	Focal seizures (HP:0007359)	2.36989015
38	Dialeptic seizures (HP:0011146)	2.28659470
39	Broad-based gait (HP:0002136)	2.25896884
40	Inability to walk (HP:0002540)	2.25464125
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.24987278
42	Increased corneal curvature (HP:0100692)	2.19194433
43	Keratoconus (HP:0000563)	2.19194433
44	Congenital primary aphakia (HP:0007707)	2.18634821
45	Gait imbalance (HP:0002141)	2.18051204
46	Large for gestational age (HP:0001520)	2.16743791
47	Congenital hepatic fibrosis (HP:0002612)	2.15036561
48	Decreased circulating renin level (HP:0003351)	2.14587781
49	Abnormality of macular pigmentation (HP:0008002)	2.14093742
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.11469278
51	Pendular nystagmus (HP:0012043)	2.10997775
52	Intestinal atresia (HP:0011100)	2.06552277
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05364200
54	Generalized hypopigmentation of hair (HP:0011358)	2.02792616
55	Decreased central vision (HP:0007663)	2.02683128
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01261057
57	Tubulointerstitial nephritis (HP:0001970)	2.01017038
58	Hypothermia (HP:0002045)	2.00347777
59	Postaxial foot polydactyly (HP:0001830)	1.99840948
60	Nephrogenic diabetes insipidus (HP:0009806)	1.99745671
61	Facial diplegia (HP:0001349)	1.98687480
62	Retinitis pigmentosa (HP:0000510)	1.97259124
63	Constricted visual fields (HP:0001133)	1.96476468
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.94016733
65	Small hand (HP:0200055)	1.92777926
66	Focal motor seizures (HP:0011153)	1.92772846
67	Cerebellar dysplasia (HP:0007033)	1.92116008
68	Chromsome breakage (HP:0040012)	1.91215930
69	Clubbing of toes (HP:0100760)	1.90897684
70	Thyroiditis (HP:0100646)	1.90542193
71	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.87960189
72	Stomatitis (HP:0010280)	1.87548280
73	Poor coordination (HP:0002370)	1.86972020
74	Abnormality of the renal collecting system (HP:0004742)	1.86818243
75	IgG deficiency (HP:0004315)	1.86089645
76	Polyuria (HP:0000103)	1.84979576
77	Abnormality of the prostate (HP:0008775)	1.84874758
78	Genital tract atresia (HP:0001827)	1.83749266
79	Sloping forehead (HP:0000340)	1.83508390
80	Severe combined immunodeficiency (HP:0004430)	1.83458241
81	Absence seizures (HP:0002121)	1.82444427
82	Widely spaced teeth (HP:0000687)	1.81307151
83	Poikiloderma (HP:0001029)	1.81100648
84	Hyperglycinuria (HP:0003108)	1.79607592
85	Furrowed tongue (HP:0000221)	1.79077320
86	Hypoplastic iliac wings (HP:0002866)	1.77877762
87	Amelogenesis imperfecta (HP:0000705)	1.77318913
88	Male pseudohermaphroditism (HP:0000037)	1.77164498
89	Severe visual impairment (HP:0001141)	1.76701682
90	Ketosis (HP:0001946)	1.76564346
91	Astigmatism (HP:0000483)	1.74425052
92	Anencephaly (HP:0002323)	1.74058654
93	Hypoproteinemia (HP:0003075)	1.72914524
94	Hyperglycinemia (HP:0002154)	1.72714981
95	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.72348848
96	Central scotoma (HP:0000603)	1.72160607
97	Abnormality of chromosome stability (HP:0003220)	1.72126460
98	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72078020
99	Absent/shortened dynein arms (HP:0200106)	1.72078020
100	Sclerocornea (HP:0000647)	1.71376846

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.65612183
2	TAOK3	3.37776845
3	BMPR1B	2.80440038
4	ADRBK2	2.66377768
5	TXK	2.62013880
6	ACVR1B	2.52155874
7	WNK3	2.37955839
8	ZAK	2.13897441
9	NUAK1	2.06217777
10	MAPK13	2.04992546
11	GRK1	1.94423358
12	MAP4K2	1.87113788
13	INSRR	1.85719777
14	PINK1	1.74634130
15	OXSR1	1.44797109
16	MAP3K7	1.44102942
17	TNK2	1.40894844
18	MAP3K4	1.38605119
19	MAPKAPK3	1.32850119
20	NTRK3	1.28006753
21	MKNK2	1.27678943
22	WNK4	1.27605175
23	PIK3CG	1.25477741
24	TEC	1.22136585
25	LATS1	1.07392541
26	STK39	1.06236666
27	MAP4K1	1.05517920
28	ADRBK1	0.95895516
29	GRK6	0.88066219
30	ITK	0.87309959
31	IKBKB	0.84211947
32	FER	0.84153806
33	AKT3	0.83946838
34	TGFBR1	0.83924444
35	IRAK1	0.83820272
36	TRPM7	0.83298293
37	CCNB1	0.82775058
38	PTK2B	0.82145641
39	STK38L	0.80834719
40	SYK	0.79635857
41	BCKDK	0.78288862
42	EIF2AK3	0.76410754
43	KIT	0.75565914
44	DAPK2	0.72791931
45	PLK4	0.72537417
46	BCR	0.72445017
47	BLK	0.71053008
48	EPHA3	0.66274460
49	PAK3	0.66051811
50	CDK19	0.64544395
51	STK38	0.64412163
52	BTK	0.64289594
53	PRKAA2	0.63638152
54	MAP2K2	0.63348263
55	MKNK1	0.62847845
56	NLK	0.58791591
57	PRKCE	0.58565208
58	ERBB3	0.57866015
59	CAMKK2	0.57853948
60	STK3	0.56342987
61	JAK1	0.56229613
62	TNIK	0.52460755
63	PRKCQ	0.52104510
64	IKBKE	0.52086624
65	PLK2	0.51641773
66	FES	0.51192660
67	MARK3	0.50913181
68	SIK2	0.48657525
69	TRIM28	0.48570607
70	LYN	0.48228084
71	PKN1	0.47353026
72	FGFR2	0.45553579
73	MAPKAPK5	0.45522586
74	MAP2K1	0.45285515
75	NME1	0.44747357
76	LCK	0.44012096
77	HCK	0.43073950
78	CHUK	0.42690198
79	EIF2AK2	0.41912999
80	PRKAA1	0.41168254
81	ATR	0.40567129
82	GRK5	0.40418074
83	MAP2K7	0.39121479
84	TLK1	0.39025733
85	MAPK11	0.38969944
86	CAMK4	0.38774538
87	PIK3CA	0.37022691
88	BMPR2	0.36609546
89	PRKCG	0.36190183
90	ABL1	0.35974950
91	CASK	0.34519173
92	MAP2K6	0.34382477
93	CAMK2A	0.33754037
94	CAMK1	0.33569096
95	MARK1	0.33330368
96	CHEK2	0.32642075
97	PIM1	0.32057113
98	SGK2	0.30746859
99	OBSCN	0.30426929
100	MUSK	0.29027727

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.86507246
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.72735295
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.58866578
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.57915779
5	Butanoate metabolism_Homo sapiens_hsa00650	2.54094558
6	ABC transporters_Homo sapiens_hsa02010	2.32026582
7	Nicotine addiction_Homo sapiens_hsa05033	2.30584026
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.26317688
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.22378154
10	Homologous recombination_Homo sapiens_hsa03440	2.21286943
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.13972967
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.02741985
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.01214227
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.93882752
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.90015080
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.89088147
17	Olfactory transduction_Homo sapiens_hsa04740	1.81666845
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.75332187
19	Taste transduction_Homo sapiens_hsa04742	1.68958596
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65287470
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.61500178
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.55219857
23	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.54158997
24	Morphine addiction_Homo sapiens_hsa05032	1.53528489
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52625903
26	Propanoate metabolism_Homo sapiens_hsa00640	1.51886920
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.45873993
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28043422
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.25130673
30	Retinol metabolism_Homo sapiens_hsa00830	1.24618811
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.23370211
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22719804
33	Caffeine metabolism_Homo sapiens_hsa00232	1.20826138
34	Serotonergic synapse_Homo sapiens_hsa04726	1.18320160
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15672267
36	Salivary secretion_Homo sapiens_hsa04970	1.15219079
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.11869062
38	Basal transcription factors_Homo sapiens_hsa03022	1.11788166
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.11010179
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09432117
41	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.06961284
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.05427295
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.04738798
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03427250
45	Circadian entrainment_Homo sapiens_hsa04713	1.00783264
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99923397
47	Lysine degradation_Homo sapiens_hsa00310	0.97160156
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93499063
49	One carbon pool by folate_Homo sapiens_hsa00670	0.92867990
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.92820346
51	GABAergic synapse_Homo sapiens_hsa04727	0.92282005
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.92106585
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91417577
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.86012353
55	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85140316
56	RNA polymerase_Homo sapiens_hsa03020	0.81069456
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.79820045
58	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.79559124
59	Circadian rhythm_Homo sapiens_hsa04710	0.79438681
60	Peroxisome_Homo sapiens_hsa04146	0.78321627
61	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.78039171
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.76427189
63	Regulation of autophagy_Homo sapiens_hsa04140	0.75546486
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75197326
65	Histidine metabolism_Homo sapiens_hsa00340	0.71765370
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71344667
67	RNA degradation_Homo sapiens_hsa03018	0.67983391
68	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.67083434
69	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66256290
70	Insulin secretion_Homo sapiens_hsa04911	0.65594121
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64938167
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62785032
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60556100
74	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60170252
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57940492
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57389522
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56232040
78	Cholinergic synapse_Homo sapiens_hsa04725	0.56144551
79	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.55111235
80	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.53952347
81	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.52849889
82	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.52485056
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.51167325
84	Purine metabolism_Homo sapiens_hsa00230	0.48166261
85	Renin secretion_Homo sapiens_hsa04924	0.48050843
86	Platelet activation_Homo sapiens_hsa04611	0.46596916
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.45641764
88	Fatty acid degradation_Homo sapiens_hsa00071	0.43979633
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43226353
90	Long-term depression_Homo sapiens_hsa04730	0.40157977
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35831745
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35800469
93	Gastric acid secretion_Homo sapiens_hsa04971	0.35735591
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35316012
95	Metabolic pathways_Homo sapiens_hsa01100	0.35216758
96	Protein export_Homo sapiens_hsa03060	0.32456595
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31501458
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30051439
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28835687
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.27635554

SCART1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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