SCD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)5.86907710
2synaptic vesicle maturation (GO:0016188)5.60100946
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.42298986
4neuron cell-cell adhesion (GO:0007158)5.15051606
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15044772
6presynaptic membrane assembly (GO:0097105)5.13707282
7central nervous system myelination (GO:0022010)4.90972566
8axon ensheathment in central nervous system (GO:0032291)4.90972566
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.87634988
10presynaptic membrane organization (GO:0097090)4.84695858
11locomotory exploration behavior (GO:0035641)4.81451001
12glutamate secretion (GO:0014047)4.80692740
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.79681860
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72580551
15cellular potassium ion homeostasis (GO:0030007)4.70532358
16synaptic vesicle exocytosis (GO:0016079)4.60496684
17vocalization behavior (GO:0071625)4.56383754
18regulation of synaptic vesicle exocytosis (GO:2000300)4.44870762
19neuronal action potential propagation (GO:0019227)4.32460574
20L-amino acid import (GO:0043092)4.32022974
21synaptic transmission, glutamatergic (GO:0035249)4.22372490
22exploration behavior (GO:0035640)4.19312561
23sodium ion export (GO:0071436)4.18567568
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.18412935
25neurotransmitter-gated ion channel clustering (GO:0072578)4.17700224
26gamma-aminobutyric acid transport (GO:0015812)4.05928632
27neurotransmitter secretion (GO:0007269)4.05581623
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05077092
29glutamate receptor signaling pathway (GO:0007215)4.03462251
30auditory behavior (GO:0031223)4.00452786
31cerebellar granule cell differentiation (GO:0021707)3.97412965
32protein localization to synapse (GO:0035418)3.96237654
33regulation of synaptic vesicle transport (GO:1902803)3.94622893
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.91785110
35amino acid import (GO:0043090)3.87655841
36potassium ion import (GO:0010107)3.84387863
37regulation of neuronal synaptic plasticity (GO:0048168)3.81498402
38neuron-neuron synaptic transmission (GO:0007270)3.77409701
39dendritic spine morphogenesis (GO:0060997)3.76210678
40potassium ion homeostasis (GO:0055075)3.72083870
41regulation of glutamate receptor signaling pathway (GO:1900449)3.61709248
42regulation of synapse structural plasticity (GO:0051823)3.60898256
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59003088
44neurotransmitter uptake (GO:0001504)3.57932508
45neuronal ion channel clustering (GO:0045161)3.57246441
46transmission of nerve impulse (GO:0019226)3.56948708
47mechanosensory behavior (GO:0007638)3.53702839
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.48598672
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.42474327
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40896763
51neurotransmitter transport (GO:0006836)3.40426769
52neuron recognition (GO:0008038)3.39405571
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.37687982
54axonal fasciculation (GO:0007413)3.37000226
55response to auditory stimulus (GO:0010996)3.30557296
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29183906
57cellular sodium ion homeostasis (GO:0006883)3.27132616
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.25648585
59regulation of neurotransmitter levels (GO:0001505)3.24286438
60positive regulation of synapse maturation (GO:0090129)3.24165293
61positive regulation of dendritic spine development (GO:0060999)3.21129740
62positive regulation of membrane potential (GO:0045838)3.20425801
63regulation of neurotransmitter secretion (GO:0046928)3.19425805
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18731392
65membrane depolarization during action potential (GO:0086010)3.17276921
66regulation of postsynaptic membrane potential (GO:0060078)3.16918475
67regulation of neurotransmitter transport (GO:0051588)3.15611841
68acidic amino acid transport (GO:0015800)3.14505972
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12702419
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11684669
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10277707
72synaptic vesicle endocytosis (GO:0048488)3.08726002
73synapse assembly (GO:0007416)3.08067184
74startle response (GO:0001964)3.07551273
75pyrimidine nucleobase catabolic process (GO:0006208)3.07549271
76dendrite morphogenesis (GO:0048813)3.07192561
77adult walking behavior (GO:0007628)3.06949236
78cell communication by electrical coupling (GO:0010644)3.05946070
79C4-dicarboxylate transport (GO:0015740)3.05211468
80regulation of dendritic spine morphogenesis (GO:0061001)3.03610982
81regulation of respiratory system process (GO:0044065)3.01718501
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01428923
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98364119
84regulation of dendritic spine development (GO:0060998)2.97093650
85regulation of voltage-gated calcium channel activity (GO:1901385)2.96043300
86membrane depolarization (GO:0051899)2.95612899
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93266346
88long-term memory (GO:0007616)2.92070164
89regulation of vesicle fusion (GO:0031338)2.89987570
90cerebellar Purkinje cell differentiation (GO:0021702)2.89831959
91regulation of synaptic plasticity (GO:0048167)2.88622998
92positive regulation of synapse assembly (GO:0051965)2.88576076
93neuromuscular process controlling balance (GO:0050885)2.87988849
94establishment of mitochondrion localization (GO:0051654)2.86122703
95long-term synaptic potentiation (GO:0060291)2.85631556
96regulation of neurotransmitter uptake (GO:0051580)2.84265309
97membrane hyperpolarization (GO:0060081)2.81168715
98synapse organization (GO:0050808)2.77842400
99neuromuscular synaptic transmission (GO:0007274)2.76907809
100positive regulation of dendritic spine morphogenesis (GO:0061003)2.76832922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38896889
2GBX2_23144817_ChIP-Seq_PC3_Human3.47570598
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.03089945
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74363993
5REST_21632747_ChIP-Seq_MESCs_Mouse2.68155302
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58965959
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54822240
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49858258
9DROSHA_22980978_ChIP-Seq_HELA_Human2.37508630
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.29583451
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29176597
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18361924
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18275109
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18275109
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17311572
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.15763159
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15630081
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14044963
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11532592
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11347340
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10839931
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10654503
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.04108863
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.01257632
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.00227782
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98423022
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96659224
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88124170
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85064377
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.84648037
31TAF15_26573619_Chip-Seq_HEK293_Human1.81069113
32AR_21572438_ChIP-Seq_LNCaP_Human1.78037073
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69784251
34SMAD4_21799915_ChIP-Seq_A2780_Human1.67474426
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65533984
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65076854
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.64498742
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57151827
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54557867
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53436150
41IGF1R_20145208_ChIP-Seq_DFB_Human1.47889535
42P300_19829295_ChIP-Seq_ESCs_Human1.46477855
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44397533
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41404624
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40967531
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.40175280
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38722099
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38082598
49RNF2_27304074_Chip-Seq_NSC_Mouse1.36822540
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.35942606
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.33955003
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33948380
53STAT3_23295773_ChIP-Seq_U87_Human1.33315004
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32078073
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.31095077
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30193355
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29691900
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26934093
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25138910
60TCF4_23295773_ChIP-Seq_U87_Human1.25097041
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22702364
62AR_25329375_ChIP-Seq_VCAP_Human1.22242036
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22165311
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21836385
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21078452
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21058023
67AR_19668381_ChIP-Seq_PC3_Human1.21025569
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17435071
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16340050
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14638395
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14638395
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12371921
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12061619
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10976372
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10286249
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08862887
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08637096
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08461157
79VDR_22108803_ChIP-Seq_LS180_Human1.07911432
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07229541
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.06263730
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.04010723
83RUNX2_22187159_ChIP-Seq_PCA_Human1.03581078
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01770285
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01695855
86KDM2B_26808549_Chip-Seq_REH_Human1.00879445
87FUS_26573619_Chip-Seq_HEK293_Human1.00728815
88RING1B_27294783_Chip-Seq_NPCs_Mouse0.99515017
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99099428
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98698181
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97288043
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96974163
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96596726
94BCAT_22108803_ChIP-Seq_LS180_Human0.96408634
95ZNF274_21170338_ChIP-Seq_K562_Hela0.95876109
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95423659
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.94758773
98SOX9_26525672_Chip-Seq_HEART_Mouse0.93696785
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.92765802
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92083492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08175050
2MP0003880_abnormal_central_pattern4.34926103
3MP0004270_analgesia3.69418021
4MP0003635_abnormal_synaptic_transmissio3.60812987
5MP0005423_abnormal_somatic_nervous3.57458213
6MP0002064_seizures3.20540966
7MP0009745_abnormal_behavioral_response3.05019509
8MP0001486_abnormal_startle_reflex2.96605779
9MP0002063_abnormal_learning/memory/cond2.90209965
10MP0002272_abnormal_nervous_system2.89172036
11MP0001968_abnormal_touch/_nociception2.87184028
12MP0009046_muscle_twitch2.86305716
13MP0002734_abnormal_mechanical_nocicepti2.65579492
14MP0002572_abnormal_emotion/affect_behav2.55567590
15MP0002736_abnormal_nociception_after2.55167804
16MP0002735_abnormal_chemical_nociception2.35667055
17MP0004885_abnormal_endolymph2.32599417
18MP0001984_abnormal_olfaction2.28278593
19MP0000778_abnormal_nervous_system2.21129161
20MP0001501_abnormal_sleep_pattern2.04357626
21MP0001970_abnormal_pain_threshold2.00518687
22MP0008569_lethality_at_weaning2.00432407
23MP0003690_abnormal_glial_cell1.96190838
24MP0003787_abnormal_imprinting1.94106835
25MP0002733_abnormal_thermal_nociception1.88697090
26MP0002067_abnormal_sensory_capabilities1.86668828
27MP0002557_abnormal_social/conspecific_i1.79600965
28MP0005646_abnormal_pituitary_gland1.78858405
29MP0009780_abnormal_chondrocyte_physiolo1.78524354
30MP0001502_abnormal_circadian_rhythm1.70690918
31MP0003329_amyloid_beta_deposits1.70243714
32MP0006276_abnormal_autonomic_nervous1.69793054
33MP0003633_abnormal_nervous_system1.64414338
34MP0000955_abnormal_spinal_cord1.62075399
35MP0000920_abnormal_myelination1.60259190
36MP0003122_maternal_imprinting1.59021792
37MP0003879_abnormal_hair_cell1.58567830
38MP0001440_abnormal_grooming_behavior1.55235866
39MP0002882_abnormal_neuron_morphology1.53072481
40MP0000569_abnormal_digit_pigmentation1.52817405
41MP0004742_abnormal_vestibular_system1.50836087
42MP0004924_abnormal_behavior1.47694286
43MP0005386_behavior/neurological_phenoty1.47694286
44MP0004811_abnormal_neuron_physiology1.45192884
45MP0005551_abnormal_eye_electrophysiolog1.43351704
46MP0003631_nervous_system_phenotype1.38464678
47MP0002066_abnormal_motor_capabilities/c1.37299479
48MP0002184_abnormal_innervation1.37060566
49MP0001905_abnormal_dopamine_level1.34034294
50MP0002909_abnormal_adrenal_gland1.33162952
51MP0001485_abnormal_pinna_reflex1.29944736
52MP0004142_abnormal_muscle_tone1.28074772
53MP0002822_catalepsy1.26572246
54MP0003634_abnormal_glial_cell1.25435755
55MP0001529_abnormal_vocalization1.23568290
56MP0003632_abnormal_nervous_system1.22296463
57MP0005167_abnormal_blood-brain_barrier1.21073630
58MP0002152_abnormal_brain_morphology1.20966547
59MP0002638_abnormal_pupillary_reflex1.20641149
60MP0001177_atelectasis1.14076076
61MP0001963_abnormal_hearing_physiology1.13908969
62MP0002229_neurodegeneration1.13193178
63MP0001986_abnormal_taste_sensitivity1.05518718
64MP0002653_abnormal_ependyma_morphology0.98909018
65MP0003283_abnormal_digestive_organ0.97193266
66MP0003136_yellow_coat_color0.96813746
67MP0000631_abnormal_neuroendocrine_gland0.94711901
68MP0004043_abnormal_pH_regulation0.94431980
69MP0005253_abnormal_eye_physiology0.93462595
70MP0005645_abnormal_hypothalamus_physiol0.92681503
71MP0010386_abnormal_urinary_bladder0.92166530
72MP0002752_abnormal_somatic_nervous0.92071454
73MP0000026_abnormal_inner_ear0.91318462
74MP0008877_abnormal_DNA_methylation0.88489361
75MP0003121_genomic_imprinting0.88113346
76MP0002069_abnormal_eating/drinking_beha0.79602326
77MP0001299_abnormal_eye_distance/0.75856321
78MP0003123_paternal_imprinting0.73894320
79MP0000566_synostosis0.73205446
80MP0005171_absent_coat_pigmentation0.73055438
81MP0003137_abnormal_impulse_conducting0.70992345
82MP0003861_abnormal_nervous_system0.70977937
83MP0001188_hyperpigmentation0.70701138
84MP0000579_abnormal_nail_morphology0.69115195
85MP0004147_increased_porphyrin_level0.65815631
86MP0008872_abnormal_physiological_respon0.62888381
87MP0004133_heterotaxia0.62603444
88MP0000639_abnormal_adrenal_gland0.59411460
89MP0005187_abnormal_penis_morphology0.59294848
90MP0002102_abnormal_ear_morphology0.59152782
91MP0006072_abnormal_retinal_apoptosis0.58920925
92MP0000604_amyloidosis0.58226578
93MP0010769_abnormal_survival0.57867616
94MP0004215_abnormal_myocardial_fiber0.56804165
95MP0010770_preweaning_lethality0.56636379
96MP0002082_postnatal_lethality0.56636379
97MP0001943_abnormal_respiration0.54717358
98MP0010768_mortality/aging0.54557129
99MP0004085_abnormal_heartbeat0.54046239
100MP0002876_abnormal_thyroid_physiology0.52824171

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.60893348
2Myokymia (HP:0002411)5.76334879
3Focal seizures (HP:0007359)5.52213053
4Febrile seizures (HP:0002373)5.29343722
5Action tremor (HP:0002345)4.69940061
6Epileptic encephalopathy (HP:0200134)4.60721576
7Atonic seizures (HP:0010819)4.52933223
8Abnormality of binocular vision (HP:0011514)4.14930328
9Diplopia (HP:0000651)4.14930328
10Progressive cerebellar ataxia (HP:0002073)4.04773257
11Generalized tonic-clonic seizures (HP:0002069)3.72186693
12Hemiparesis (HP:0001269)3.69850775
13Hyperventilation (HP:0002883)3.64850031
14Limb dystonia (HP:0002451)3.60667111
15Dialeptic seizures (HP:0011146)3.59670032
16Absence seizures (HP:0002121)3.49728993
17Neurofibrillary tangles (HP:0002185)3.48742445
18Abnormal eating behavior (HP:0100738)3.34587615
19Hemiplegia (HP:0002301)3.26741043
20Ankle clonus (HP:0011448)3.20274436
21Truncal ataxia (HP:0002078)3.10923984
22Supranuclear gaze palsy (HP:0000605)3.04000088
23Spastic gait (HP:0002064)2.92397271
24Dysdiadochokinesis (HP:0002075)2.90662762
25Megalencephaly (HP:0001355)2.90391521
26Gaze-evoked nystagmus (HP:0000640)2.90055041
27Increased circulating renin level (HP:0000848)2.89873114
28Intention tremor (HP:0002080)2.89391873
29Epileptiform EEG discharges (HP:0011182)2.88919698
30Broad-based gait (HP:0002136)2.84891676
31Urinary bladder sphincter dysfunction (HP:0002839)2.84660060
32Genetic anticipation (HP:0003743)2.78891631
33Abnormality of the corticospinal tract (HP:0002492)2.75095055
34Absent speech (HP:0001344)2.69907019
35Drooling (HP:0002307)2.69071682
36Peripheral hypomyelination (HP:0007182)2.67471950
37EEG with generalized epileptiform discharges (HP:0011198)2.67171490
38Postural instability (HP:0002172)2.59166701
39Polyphagia (HP:0002591)2.55175232
40Hypsarrhythmia (HP:0002521)2.54789584
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49002626
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.49002626
43Status epilepticus (HP:0002133)2.48299938
44Dysmetria (HP:0001310)2.47402139
45Split foot (HP:0001839)2.43961623
46Excessive salivation (HP:0003781)2.43189572
47Cerebral inclusion bodies (HP:0100314)2.38999376
48Mutism (HP:0002300)2.38813264
49Torticollis (HP:0000473)2.37101527
50Urinary urgency (HP:0000012)2.34186014
51Akinesia (HP:0002304)2.33810897
52Gait imbalance (HP:0002141)2.33149081
53Anxiety (HP:0000739)2.32200168
54Impaired vibration sensation in the lower limbs (HP:0002166)2.29752717
55Sleep apnea (HP:0010535)2.26509779
56Papilledema (HP:0001085)2.25921110
57Visual hallucinations (HP:0002367)2.23704225
58Lower limb muscle weakness (HP:0007340)2.21728802
59Impaired smooth pursuit (HP:0007772)2.17720436
60Poor eye contact (HP:0000817)2.14956035
61Morphological abnormality of the pyramidal tract (HP:0002062)2.14495500
62Obstructive sleep apnea (HP:0002870)2.13881227
63Scanning speech (HP:0002168)2.12585556
64Cerebral hypomyelination (HP:0006808)2.00189340
65Spastic tetraparesis (HP:0001285)1.99418039
66Amblyopia (HP:0000646)1.98385001
67Oligodactyly (hands) (HP:0001180)1.95038413
68Amyotrophic lateral sclerosis (HP:0007354)1.94782302
69Abnormality of ocular smooth pursuit (HP:0000617)1.94593505
70Clonus (HP:0002169)1.92464272
71Depression (HP:0000716)1.89604809
72Aplasia involving bones of the upper limbs (HP:0009823)1.89344017
73Aplasia of the phalanges of the hand (HP:0009802)1.89344017
74Aplasia involving bones of the extremities (HP:0009825)1.89344017
75Bradykinesia (HP:0002067)1.85923065
76Impaired social interactions (HP:0000735)1.82344212
77Abnormal social behavior (HP:0012433)1.82344212
78Protruding tongue (HP:0010808)1.80774842
79Metabolic alkalosis (HP:0200114)1.80144516
80Impaired vibratory sensation (HP:0002495)1.79468180
81Focal dystonia (HP:0004373)1.79176973
82Hypokalemic alkalosis (HP:0001949)1.77810290
83Hypoplasia of the corpus callosum (HP:0002079)1.77578832
84Thickened helices (HP:0000391)1.76298490
85Abnormal drinking behavior (HP:0030082)1.72606113
86Polydipsia (HP:0001959)1.72606113
87Specific learning disability (HP:0001328)1.69522510
88Stereotypic behavior (HP:0000733)1.68813471
89Prolonged QT interval (HP:0001657)1.68737898
90Hyperaldosteronism (HP:0000859)1.67085528
91Medial flaring of the eyebrow (HP:0010747)1.65092900
92Cutaneous finger syndactyly (HP:0010554)1.63900247
93Spastic tetraplegia (HP:0002510)1.63812257
94Alacrima (HP:0000522)1.63479009
95Fetal akinesia sequence (HP:0001989)1.62442723
96Morphological abnormality of the inner ear (HP:0011390)1.61534875
97Agitation (HP:0000713)1.60914463
98Hypomagnesemia (HP:0002917)1.59360603
99Congenital primary aphakia (HP:0007707)1.59078847
100Postural tremor (HP:0002174)1.59000381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.11887489
2NTRK34.37543820
3CASK4.20203317
4EPHA43.56929967
5NTRK23.20003457
6FRK3.00037183
7PAK62.49221278
8DAPK22.31183207
9UHMK12.27382139
10MAPK132.18384099
11PRKD31.94428130
12NTRK11.84311670
13MINK11.84174955
14PINK11.79566113
15MAP3K41.76250758
16PHKG21.72185151
17PHKG11.72185151
18SIK21.54234045
19PLK21.53685770
20TNIK1.52385750
21CAMKK11.51993487
22PRKCG1.50058787
23WNK31.47007003
24SGK4941.38549788
25SGK2231.38549788
26CAMK2B1.38277914
27CDK51.35428710
28PKN11.34526937
29TYRO31.33925081
30MAP3K91.30242901
31SGK21.28784577
32FGFR21.26409442
33MAP2K71.24192845
34PAK31.23429915
35CAMK2A1.16903255
36CSNK1G21.16296000
37PNCK1.05729116
38DYRK1A0.97181440
39CAMK10.95080331
40CAMKK20.94802639
41CAMK2G0.93893662
42GRK50.93695282
43PRKCH0.91372325
44NEK60.89131149
45SGK10.85642970
46CAMK2D0.83493460
47DYRK20.82542929
48STK380.82173018
49SGK30.80447131
50OXSR10.77489821
51PRKCE0.76968836
52TNK20.72179225
53LATS20.71861898
54CSNK1G30.71757490
55STK110.71092517
56ROCK20.70126124
57BMPR1B0.70025973
58CSNK1A1L0.69969421
59CDK150.69492145
60CDK180.69489445
61STK38L0.66922027
62MAP2K40.66328662
63MAPK100.65739948
64CDK140.64528394
65PRKCZ0.62817211
66STK390.62648693
67KSR10.62093725
68MARK20.61560112
69BCR0.59755857
70CDK11A0.59615051
71CSNK1G10.59134830
72CAMK40.57056863
73RPS6KA30.55516458
74ROCK10.55366365
75LMTK20.54687514
76CSNK1D0.53717622
77FES0.52775002
78MAPKAPK50.52634571
79KSR20.51567488
80MAPK120.51557378
81ERBB20.50779107
82DAPK10.50090217
83LIMK10.47482629
84MAP4K20.46869651
85RIPK10.46715899
86PRKG10.46673476
87ERBB30.41897346
88PRKACA0.40414345
89ALK0.39457001
90CSNK1A10.39307343
91INSRR0.39223314
92AKT30.39068286
93ADRBK20.37845729
94WNK10.37411232
95PRKCA0.37354781
96CAMK1G0.37022981
97CDK190.35217433
98MKNK20.35130214
99PIK3CA0.34922019
100FYN0.33857603

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.32149579
2GABAergic synapse_Homo sapiens_hsa047272.98159916
3Synaptic vesicle cycle_Homo sapiens_hsa047212.89927306
4Circadian entrainment_Homo sapiens_hsa047132.87693679
5Glutamatergic synapse_Homo sapiens_hsa047242.86554327
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76402527
7Morphine addiction_Homo sapiens_hsa050322.74514074
8Insulin secretion_Homo sapiens_hsa049112.53669721
9Amphetamine addiction_Homo sapiens_hsa050312.41047810
10Dopaminergic synapse_Homo sapiens_hsa047282.21664063
11Long-term potentiation_Homo sapiens_hsa047202.21290279
12Gastric acid secretion_Homo sapiens_hsa049712.05063196
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99919662
14Cocaine addiction_Homo sapiens_hsa050301.96104939
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90946809
16Salivary secretion_Homo sapiens_hsa049701.81427748
17Taste transduction_Homo sapiens_hsa047421.78009743
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74058833
19Cholinergic synapse_Homo sapiens_hsa047251.72554095
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70355161
21Long-term depression_Homo sapiens_hsa047301.61283686
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60475285
23Renin secretion_Homo sapiens_hsa049241.56264848
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50520237
25cAMP signaling pathway_Homo sapiens_hsa040241.47111890
26Oxytocin signaling pathway_Homo sapiens_hsa049211.41773406
27Serotonergic synapse_Homo sapiens_hsa047261.40505795
28Calcium signaling pathway_Homo sapiens_hsa040201.40366741
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37924953
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35714206
31Olfactory transduction_Homo sapiens_hsa047401.24348146
32Phototransduction_Homo sapiens_hsa047441.21046247
33Estrogen signaling pathway_Homo sapiens_hsa049151.13171662
34Gap junction_Homo sapiens_hsa045401.11125307
35Axon guidance_Homo sapiens_hsa043601.10168689
36Dorso-ventral axis formation_Homo sapiens_hsa043201.06463990
37Bile secretion_Homo sapiens_hsa049761.05353370
38Pancreatic secretion_Homo sapiens_hsa049721.03433611
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02188349
40Butanoate metabolism_Homo sapiens_hsa006500.99762969
41Collecting duct acid secretion_Homo sapiens_hsa049660.99758461
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99127970
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95856865
44Thyroid hormone synthesis_Homo sapiens_hsa049180.94748207
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94048542
46Melanogenesis_Homo sapiens_hsa049160.91638152
47Vitamin B6 metabolism_Homo sapiens_hsa007500.90674384
48Nitrogen metabolism_Homo sapiens_hsa009100.89654299
49Cardiac muscle contraction_Homo sapiens_hsa042600.87774553
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.87473605
51GnRH signaling pathway_Homo sapiens_hsa049120.87385478
52Circadian rhythm_Homo sapiens_hsa047100.85548812
53Glioma_Homo sapiens_hsa052140.85108534
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.85028833
55Type II diabetes mellitus_Homo sapiens_hsa049300.83961916
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82933041
57beta-Alanine metabolism_Homo sapiens_hsa004100.80855188
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77977076
59Histidine metabolism_Homo sapiens_hsa003400.77414197
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75326197
61Ras signaling pathway_Homo sapiens_hsa040140.71938876
62ErbB signaling pathway_Homo sapiens_hsa040120.69247431
63Oocyte meiosis_Homo sapiens_hsa041140.68175079
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67769815
65Ovarian steroidogenesis_Homo sapiens_hsa049130.64685690
66Rap1 signaling pathway_Homo sapiens_hsa040150.60868713
67Vibrio cholerae infection_Homo sapiens_hsa051100.58291581
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58033645
69Dilated cardiomyopathy_Homo sapiens_hsa054140.55947895
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55780112
71MAPK signaling pathway_Homo sapiens_hsa040100.55566705
72ABC transporters_Homo sapiens_hsa020100.53117826
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52642546
74Hippo signaling pathway_Homo sapiens_hsa043900.52340607
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52109478
76Fatty acid biosynthesis_Homo sapiens_hsa000610.51361373
77Choline metabolism in cancer_Homo sapiens_hsa052310.51289500
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48683425
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47722539
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45418571
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.45104648
82Prion diseases_Homo sapiens_hsa050200.45064527
83Inositol phosphate metabolism_Homo sapiens_hsa005620.44713202
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.44003107
85Wnt signaling pathway_Homo sapiens_hsa043100.42288235
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39495157
87Alcoholism_Homo sapiens_hsa050340.39379555
88Mineral absorption_Homo sapiens_hsa049780.38704571
89Ether lipid metabolism_Homo sapiens_hsa005650.37307996
90Hedgehog signaling pathway_Homo sapiens_hsa043400.36578308
91Arginine and proline metabolism_Homo sapiens_hsa003300.35111903
92Regulation of autophagy_Homo sapiens_hsa041400.34276368
93Glucagon signaling pathway_Homo sapiens_hsa049220.34209791
94Tight junction_Homo sapiens_hsa045300.31881098
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29071639
96mTOR signaling pathway_Homo sapiens_hsa041500.24618897
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23167982
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.22919562
99Endocytosis_Homo sapiens_hsa041440.22407574
100Glycerolipid metabolism_Homo sapiens_hsa005610.22286539

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