ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	growth hormone secretion (GO:0030252)	7.59653990
2	ganglion development (GO:0061548)	7.36305520
3	negative regulation of oligodendrocyte differentiation (GO:0048715)	7.15748808
4	spinal cord association neuron differentiation (GO:0021527)	6.87433199
5	cerebral cortex neuron differentiation (GO:0021895)	6.21396690
6	regulation of timing of cell differentiation (GO:0048505)	6.01264197
7	positive regulation of growth hormone secretion (GO:0060124)	6.00422807
8	forebrain neuron differentiation (GO:0021879)	5.85082953
9	auditory behavior (GO:0031223)	5.36427751
10	regulation of development, heterochronic (GO:0040034)	5.31805011
11	multicellular organismal movement (GO:0050879)	5.26189651
12	musculoskeletal movement (GO:0050881)	5.26189651
13	dendritic spine morphogenesis (GO:0060997)	5.18119170
14	response to folic acid (GO:0051593)	5.16256530
15	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.02156445
16	lung secretory cell differentiation (GO:0061140)	4.99933500
17	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	4.93884485
18	postsynaptic membrane organization (GO:0001941)	4.91750738
19	regulation of transcription involved in cell fate commitment (GO:0060850)	4.85930759
20	neuroblast proliferation (GO:0007405)	4.49346108
21	neuron fate commitment (GO:0048663)	4.43337380
22	sympathetic nervous system development (GO:0048485)	4.39645920
23	pyrimidine nucleobase catabolic process (GO:0006208)	4.39225393
24	regulation of growth hormone secretion (GO:0060123)	4.20935953
25	vocalization behavior (GO:0071625)	4.18927475
26	negative regulation of glial cell differentiation (GO:0045686)	4.12181778
27	olfactory bulb development (GO:0021772)	4.00167432
28	regulation of oligodendrocyte differentiation (GO:0048713)	3.89525629
29	mechanosensory behavior (GO:0007638)	3.89281253
30	response to auditory stimulus (GO:0010996)	3.84209518
31	reflex (GO:0060004)	3.83092574
32	neuron fate specification (GO:0048665)	3.71702496
33	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.62429632
34	glandular epithelial cell differentiation (GO:0002067)	3.58313444
35	central nervous system neuron development (GO:0021954)	3.55669597
36	hippocampus development (GO:0021766)	3.52121632
37	gamma-aminobutyric acid transport (GO:0015812)	3.50657265
38	layer formation in cerebral cortex (GO:0021819)	3.44641147
39	nucleobase catabolic process (GO:0046113)	3.43299094
40	regulation of synapse structural plasticity (GO:0051823)	3.39281599
41	response to food (GO:0032094)	3.38834303
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.38511012
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.38511012
44	regulation of circadian sleep/wake cycle, sleep (GO:0045187)	3.35226689
45	regulation of circadian sleep/wake cycle (GO:0042749)	3.35226689
46	G-protein coupled receptor internalization (GO:0002031)	3.33403555
47	microtubule nucleation (GO:0007020)	3.31436959
48	proximal/distal pattern formation (GO:0009954)	3.28399680
49	negative regulation of muscle hypertrophy (GO:0014741)	3.28241427
50	protein localization to synapse (GO:0035418)	3.21981694
51	dendritic spine organization (GO:0097061)	3.19037274
52	negative regulation of catenin import into nucleus (GO:0035414)	3.18932041
53	regulation of plasminogen activation (GO:0010755)	3.17804252
54	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.16944643
55	muscle atrophy (GO:0014889)	3.16554330
56	homocysteine metabolic process (GO:0050667)	3.14900483
57	negative regulation of DNA biosynthetic process (GO:2000279)	3.09632057
58	alternative mRNA splicing, via spliceosome (GO:0000380)	3.07777283
59	positive regulation of circadian rhythm (GO:0042753)	3.07373383
60	establishment of mitochondrion localization (GO:0051654)	3.06738668
61	negative regulation of gliogenesis (GO:0014014)	3.06612308
62	synaptic vesicle maturation (GO:0016188)	3.05428341
63	behavioral response to nicotine (GO:0035095)	3.01907026
64	cysteine metabolic process (GO:0006534)	2.98961613
65	response to gravity (GO:0009629)	2.97962153
66	negative regulation of Notch signaling pathway (GO:0045746)	2.97879899
67	response to lithium ion (GO:0010226)	2.95670941
68	astrocyte differentiation (GO:0048708)	2.94877386
69	central nervous system projection neuron axonogenesis (GO:0021952)	2.93938072
70	neuron cell-cell adhesion (GO:0007158)	2.93148107
71	cell differentiation in spinal cord (GO:0021515)	2.91407037
72	lens fiber cell development (GO:0070307)	2.90349795
73	cochlea development (GO:0090102)	2.88885864
74	positive regulation of endothelial cell differentiation (GO:0045603)	2.88551416
75	white fat cell differentiation (GO:0050872)	2.87824912
76	cellular potassium ion homeostasis (GO:0030007)	2.86739000
77	skeletal muscle adaptation (GO:0043501)	2.82559898
78	cAMP-mediated signaling (GO:0019933)	2.81357164
79	protein localization to microtubule (GO:0035372)	2.80690317
80	positive regulation of RNA splicing (GO:0033120)	2.75255166
81	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.74499281
82	positive regulation of neural precursor cell proliferation (GO:2000179)	2.74399838
83	otic vesicle formation (GO:0030916)	2.70698024
84	striated muscle atrophy (GO:0014891)	2.70502127
85	inner ear receptor cell development (GO:0060119)	2.70234962
86	circadian sleep/wake cycle process (GO:0022410)	2.66322470
87	positive regulation of Notch signaling pathway (GO:0045747)	2.65525171
88	lung cell differentiation (GO:0060479)	2.64833338
89	negative regulation of Ras GTPase activity (GO:0034261)	2.64287882
90	purine nucleotide salvage (GO:0032261)	2.63818823
91	regulation of synaptic vesicle exocytosis (GO:2000300)	2.62458220
92	sulfur amino acid catabolic process (GO:0000098)	2.59333090
93	lung epithelial cell differentiation (GO:0060487)	2.55486471
94	striatum development (GO:0021756)	2.54748631
95	presynaptic membrane assembly (GO:0097105)	2.54322910
96	cell proliferation in forebrain (GO:0021846)	2.53238444
97	regulation of skeletal muscle contraction (GO:0014819)	2.52873856
98	cranial nerve morphogenesis (GO:0021602)	2.52778978
99	cartilage morphogenesis (GO:0060536)	2.50185626
100	peristalsis (GO:0030432)	2.49820154

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.45006854
2	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	4.06161038
3	EED_16625203_ChIP-ChIP_MESCs_Mouse	3.86156309
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.52270297
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	3.14684626
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.00820678
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.99056414
8	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.97878760
9	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.86545726
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.83647795
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.81858783
12	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.81352985
13	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.81352985
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.72582774
15	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.72366649
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.66782865
17	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.64192731
18	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.52102646
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.44114292
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.42074578
21	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.28711434
22	TP53_20018659_ChIP-ChIP_R1E_Mouse	2.25875942
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.24197824
24	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.20203432
25	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.20203432
26	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.20203432
27	REST_21632747_ChIP-Seq_MESCs_Mouse	2.19071685
28	SOX2_16153702_ChIP-ChIP_HESCs_Human	2.15221303
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.09229922
30	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.06075600
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06000415
32	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.94165822
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85485171
34	VDR_22108803_ChIP-Seq_LS180_Human	1.85483676
35	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.82689467
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.81475601
37	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.66394863
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63976446
39	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.55975327
40	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.52432460
41	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.51757475
42	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.50405304
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45590535
44	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.42468975
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36205275
46	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.36025168
47	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.29732474
48	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.29576965
49	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.28924014
50	SOX9_26525672_Chip-Seq_HEART_Mouse	1.28539649
51	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.27036267
52	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.25851026
53	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.25028060
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22869529
55	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.22337199
56	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.22193033
57	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.22059474
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19440556
59	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.16590784
60	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.15676192
61	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13620162
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.10500731
63	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.10179124
64	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.06431065
65	DROSHA_22980978_ChIP-Seq_HELA_Human	1.06383983
66	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.05820420
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02877210
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02877210
69	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.02311846
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02270427
71	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.99299806
72	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.98613282
73	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.98518375
74	TAF15_26573619_Chip-Seq_HEK293_Human	0.97601290
75	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.96933353
76	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96087698
77	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.95913988
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95174475
79	ZNF274_21170338_ChIP-Seq_K562_Hela	0.93949910
80	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.93761812
81	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93619363
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.93566024
83	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.92932268
84	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.90537900
85	RXR_22108803_ChIP-Seq_LS180_Human	0.86279579
86	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.86195247
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.86057256
88	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.83443048
89	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.83073308
90	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.82772807
91	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.80212284
92	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.79638498
93	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.79284255
94	FUS_26573619_Chip-Seq_HEK293_Human	0.78967089
95	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.78797967
96	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.78666659
97	CTCF_27219007_Chip-Seq_Bcells_Human	0.77910920
98	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.77359123
99	P300_19829295_ChIP-Seq_ESCs_Human	0.77013760
100	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.76583035

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	6.40011206
2	MP0008789_abnormal_olfactory_epithelium	3.96425644
3	MP0005499_abnormal_olfactory_system	3.28208920
4	MP0005394_taste/olfaction_phenotype	3.28208920
5	MP0000566_synostosis	3.19225890
6	MP0005646_abnormal_pituitary_gland	2.52901401
7	MP0006072_abnormal_retinal_apoptosis	2.44570760
8	MP0001529_abnormal_vocalization	2.44026156
9	MP0004270_analgesia	2.32642161
10	MP0004885_abnormal_endolymph	2.29341002
11	MP0002095_abnormal_skin_pigmentation	2.28450771
12	MP0002735_abnormal_chemical_nociception	2.13068243
13	MP0000778_abnormal_nervous_system	2.05088817
14	MP0005670_abnormal_white_adipose	1.99495991
15	MP0002734_abnormal_mechanical_nocicepti	1.95974116
16	MP0000537_abnormal_urethra_morphology	1.94082163
17	MP0001968_abnormal_touch/_nociception	1.92043236
18	MP0005423_abnormal_somatic_nervous	1.91065055
19	MP0000049_abnormal_middle_ear	1.87405480
20	MP0000013_abnormal_adipose_tissue	1.84671674
21	MP0000631_abnormal_neuroendocrine_gland	1.79622737
22	MP0009745_abnormal_behavioral_response	1.68032585
23	MP0002736_abnormal_nociception_after	1.64150343
24	MP0003635_abnormal_synaptic_transmissio	1.62266767
25	MP0005409_darkened_coat_color	1.58733084
26	MP0003705_abnormal_hypodermis_morpholog	1.55564834
27	MP0000955_abnormal_spinal_cord	1.51431179
28	MP0002064_seizures	1.50753941
29	MP0002751_abnormal_autonomic_nervous	1.49016362
30	MP0001486_abnormal_startle_reflex	1.46467512
31	MP0010030_abnormal_orbit_morphology	1.45135587
32	MP0004133_heterotaxia	1.42148532
33	MP0006292_abnormal_olfactory_placode	1.38847198
34	MP0005253_abnormal_eye_physiology	1.37993566
35	MP0002184_abnormal_innervation	1.33456608
36	MP0002063_abnormal_learning/memory/cond	1.33089090
37	MP0004811_abnormal_neuron_physiology	1.30786148
38	MP0004142_abnormal_muscle_tone	1.30322574
39	MP0002572_abnormal_emotion/affect_behav	1.25864658
40	MP0000579_abnormal_nail_morphology	1.22768442
41	MP0000747_muscle_weakness	1.22654533
42	MP0002938_white_spotting	1.19978742
43	MP0001984_abnormal_olfaction	1.19317904
44	MP0002233_abnormal_nose_morphology	1.17826582
45	MP0002557_abnormal_social/conspecific_i	1.17460878
46	MP0000026_abnormal_inner_ear	1.17148869
47	MP0002638_abnormal_pupillary_reflex	1.14244576
48	MP0002069_abnormal_eating/drinking_beha	1.13550292
49	MP0002733_abnormal_thermal_nociception	1.12732972
50	MP0001440_abnormal_grooming_behavior	1.08855957
51	MP0003755_abnormal_palate_morphology	1.07827272
52	MP0002882_abnormal_neuron_morphology	1.07361470
53	MP0001661_extended_life_span	1.06399739
54	MP0004859_abnormal_synaptic_plasticity	1.05113093
55	MP0000003_abnormal_adipose_tissue	1.05080337
56	MP0001502_abnormal_circadian_rhythm	1.04833865
57	MP0002089_abnormal_postnatal_growth/wei	1.03994431
58	MP0001270_distended_abdomen	1.03509819
59	MP0001348_abnormal_lacrimal_gland	1.01220158
60	MP0004924_abnormal_behavior	1.01075664
61	MP0005386_behavior/neurological_phenoty	1.01075664
62	MP0003861_abnormal_nervous_system	1.00521036
63	MP0003938_abnormal_ear_development	0.99932660
64	MP0005167_abnormal_blood-brain_barrier	0.97824020
65	MP0006276_abnormal_autonomic_nervous	0.97705001
66	MP0002272_abnormal_nervous_system	0.97600831
67	MP0004215_abnormal_myocardial_fiber	0.95355159
68	MP0001905_abnormal_dopamine_level	0.93617107
69	MP0003942_abnormal_urinary_system	0.93376545
70	MP0002653_abnormal_ependyma_morphology	0.92681746
71	MP0002152_abnormal_brain_morphology	0.92638587
72	MP0000751_myopathy	0.92570997
73	MP0003937_abnormal_limbs/digits/tail_de	0.90225399
74	MP0002752_abnormal_somatic_nervous	0.89784533
75	MP0001970_abnormal_pain_threshold	0.88391772
76	MP0000534_abnormal_ureter_morphology	0.88069084
77	MP0003880_abnormal_central_pattern	0.87517937
78	MP0001188_hyperpigmentation	0.86858223
79	MP0000647_abnormal_sebaceous_gland	0.81535572
80	MP0008995_early_reproductive_senescence	0.81435356
81	MP0000759_abnormal_skeletal_muscle	0.81076742
82	MP0005551_abnormal_eye_electrophysiolog	0.80890245
83	MP0003935_abnormal_craniofacial_develop	0.79937195
84	MP0009046_muscle_twitch	0.79267563
85	MP0001943_abnormal_respiration	0.78934165
86	MP0004145_abnormal_muscle_electrophysio	0.78717615
87	MP0002066_abnormal_motor_capabilities/c	0.77808653
88	MP0005645_abnormal_hypothalamus_physiol	0.76599888
89	MP0001340_abnormal_eyelid_morphology	0.76102353
90	MP0004742_abnormal_vestibular_system	0.74419648
91	MP0009250_abnormal_appendicular_skeleto	0.72636662
92	MP0002081_perinatal_lethality	0.71706198
93	MP0003890_abnormal_embryonic-extraembry	0.70973655
94	MP0003948_abnormal_gas_homeostasis	0.68318764
95	MP0000428_abnormal_craniofacial_morphol	0.68006180
96	MP0001986_abnormal_taste_sensitivity	0.67776820
97	MP0002067_abnormal_sensory_capabilities	0.67628416
98	MP0005391_vision/eye_phenotype	0.66198927
99	MP0005360_urolithiasis	0.65660075
100	MP0003634_abnormal_glial_cell	0.65599467

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Action tremor (HP:0002345)	5.16012210
2	Hypoventilation (HP:0002791)	4.54527969
3	Abnormality of alanine metabolism (HP:0010916)	4.29707483
4	Hyperalaninemia (HP:0003348)	4.29707483
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.29707483
6	Decreased circulating renin level (HP:0003351)	4.16721197
7	Maternal diabetes (HP:0009800)	3.99588353
8	Absent septum pellucidum (HP:0001331)	3.59578767
9	Palpebral edema (HP:0100540)	3.37373395
10	Aqueductal stenosis (HP:0002410)	3.28156394
11	Congenital sensorineural hearing impairment (HP:0008527)	3.19269748
12	Abnormality of the septum pellucidum (HP:0007375)	3.05135339
13	Septo-optic dysplasia (HP:0100842)	3.02925676
14	Shallow orbits (HP:0000586)	2.98971563
15	Broad metatarsal (HP:0001783)	2.96383582
16	Myokymia (HP:0002411)	2.93086311
17	Progressive cerebellar ataxia (HP:0002073)	2.91014998
18	Midline defect of the nose (HP:0004122)	2.87150727
19	Constricted visual fields (HP:0001133)	2.80215433
20	Sleep apnea (HP:0010535)	2.70633308
21	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.65461736
22	Obstructive sleep apnea (HP:0002870)	2.63509602
23	Myelomeningocele (HP:0002475)	2.59635049
24	Stenosis of the external auditory canal (HP:0000402)	2.58000259
25	Abnormality of the fetal cardiovascular system (HP:0010948)	2.54898492
26	Abnormal umbilical cord blood vessels (HP:0011403)	2.54898492
27	Single umbilical artery (HP:0001195)	2.54898492
28	Abnormality of the parietal bone (HP:0002696)	2.52934157
29	Urinary bladder sphincter dysfunction (HP:0002839)	2.49197375
30	Birth length less than 3rd percentile (HP:0003561)	2.47219420
31	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.41724070
32	White forelock (HP:0002211)	2.36066082
33	2-3 toe syndactyly (HP:0004691)	2.35737890
34	Aplasia involving bones of the extremities (HP:0009825)	2.34113212
35	Aplasia involving bones of the upper limbs (HP:0009823)	2.34113212
36	Aplasia of the phalanges of the hand (HP:0009802)	2.34113212
37	Myopathic facies (HP:0002058)	2.25736221
38	Calcaneovalgus deformity (HP:0001848)	2.23513335
39	Anxiety (HP:0000739)	2.19938350
40	Mask-like facies (HP:0000298)	2.19468086
41	Heterochromia iridis (HP:0001100)	2.18090375
42	Back pain (HP:0003418)	2.16093224
43	Esophageal atresia (HP:0002032)	2.15338489
44	Torticollis (HP:0000473)	2.14618833
45	Choanal stenosis (HP:0000452)	2.14193609
46	Neuroblastic tumors (HP:0004376)	2.13875865
47	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	2.13875865
48	Neuroblastoma (HP:0003006)	2.13875865
49	Primitive neuroectodermal tumor (HP:0030065)	2.13875865
50	Poor speech (HP:0002465)	2.12278783
51	Abnormality of renin-angiotensin system (HP:0000847)	2.08994928
52	Akinesia (HP:0002304)	2.08842749
53	Polydipsia (HP:0001959)	2.07367541
54	Abnormal drinking behavior (HP:0030082)	2.07367541
55	Hypsarrhythmia (HP:0002521)	2.07030594
56	Abnormality of the middle phalanges of the toes (HP:0010183)	2.06574075
57	Abnormality of the labia minora (HP:0012880)	2.06010674
58	EEG with generalized epileptiform discharges (HP:0011198)	2.02244478
59	Cutaneous finger syndactyly (HP:0010554)	2.02124107
60	Depression (HP:0000716)	2.00717734
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.00376401
62	Abnormality of the 2nd finger (HP:0004100)	1.98964179
63	Patchy hypopigmentation of hair (HP:0011365)	1.98739313
64	Limb dystonia (HP:0002451)	1.96276602
65	Oligomenorrhea (HP:0000876)	1.95514946
66	Meningocele (HP:0002435)	1.94962823
67	Epileptiform EEG discharges (HP:0011182)	1.91564413
68	Deformed tarsal bones (HP:0008119)	1.90105942
69	Chorioretinal atrophy (HP:0000533)	1.89163360
70	Mutism (HP:0002300)	1.88142203
71	Esophageal varix (HP:0002040)	1.87591594
72	Abnormality of the corticospinal tract (HP:0002492)	1.86880045
73	Morphological abnormality of the pyramidal tract (HP:0002062)	1.84359670
74	Postural tremor (HP:0002174)	1.83683859
75	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.83484344
76	Humeroradial synostosis (HP:0003041)	1.81651656
77	Synostosis involving the elbow (HP:0003938)	1.81651656
78	Visceral angiomatosis (HP:0100761)	1.81515870
79	Ankle clonus (HP:0011448)	1.78461003
80	Partial duplication of the phalanx of hand (HP:0009999)	1.77852025
81	Homocystinuria (HP:0002156)	1.76305827
82	Abnormality of homocysteine metabolism (HP:0010919)	1.76305827
83	Split foot (HP:0001839)	1.75533160
84	Coronal craniosynostosis (HP:0004440)	1.74650378
85	Epileptic encephalopathy (HP:0200134)	1.73948163
86	Broad hallux (HP:0010055)	1.73013326
87	Abnormality of the lower motor neuron (HP:0002366)	1.72259967
88	Gastrointestinal atresia (HP:0002589)	1.68623833
89	Cutaneous syndactyly (HP:0012725)	1.68389878
90	Supranuclear gaze palsy (HP:0000605)	1.65973322
91	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.64561062
92	Short 4th metacarpal (HP:0010044)	1.64561062
93	Cavernous hemangioma (HP:0001048)	1.64209851
94	Absent speech (HP:0001344)	1.60624704
95	Inappropriate behavior (HP:0000719)	1.59995251
96	Spontaneous hematomas (HP:0007420)	1.59239096
97	Impaired social interactions (HP:0000735)	1.58400499
98	Abnormal social behavior (HP:0012433)	1.58400499
99	Turricephaly (HP:0000262)	1.57116590
100	Tented upper lip vermilion (HP:0010804)	1.56433067

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHB2	3.79101191
2	MARK1	3.51577105
3	PRKD3	3.01651238
4	CASK	2.96126183
5	FGFR2	2.70169838
6	PNCK	2.67379090
7	INSRR	2.61884711
8	PHKG2	2.53032126
9	PHKG1	2.53032126
10	ZAK	2.50938520
11	TLK1	2.39798646
12	NTRK3	2.34970145
13	NTRK2	2.31529688
14	TNIK	2.19633093
15	MOS	2.19284570
16	DYRK2	2.17197071
17	TAF1	2.14372470
18	PAK6	1.96540775
19	VRK1	1.84717486
20	CDK9	1.83149191
21	SGK223	1.69913856
22	SGK494	1.69913856
23	CAMK1D	1.64764542
24	CAMK1G	1.62988352
25	AURKA	1.61684906
26	CSNK1G2	1.60325966
27	EPHA3	1.40731805
28	SGK2	1.37985497
29	CCNB1	1.21051169
30	WNK3	1.20122781
31	CSNK1G3	1.15754409
32	MAPK13	1.11802727
33	CSNK1A1L	1.11403504
34	NTRK1	1.06028480
35	PKN1	1.05972312
36	EPHA4	0.99166070
37	SGK3	0.96479321
38	MAP3K4	0.96132607
39	NEK9	0.95374620
40	MINK1	0.95055420
41	CSNK1G1	0.93419991
42	CDK5	0.92321226
43	UHMK1	0.88916360
44	STK11	0.88755889
45	TYRO3	0.87279756
46	MARK2	0.86629197
47	FGR	0.84139611
48	LMTK2	0.82499995
49	MAP2K7	0.81901909
50	LIMK1	0.79851276
51	ERBB2	0.78852069
52	GRK7	0.78473748
53	DYRK1B	0.75190114
54	DYRK1A	0.72126867
55	CAMK1	0.71498453
56	BCR	0.71295643
57	DAPK3	0.70032270
58	TESK1	0.69071684
59	RPS6KA2	0.65932750
60	MAP3K3	0.65539717
61	TSSK6	0.62708140
62	LATS2	0.62456350
63	RPS6KA5	0.58668502
64	AKT2	0.57645966
65	CAMK2D	0.56061511
66	BLK	0.53965551
67	PRKCE	0.52491846
68	KSR1	0.51745279
69	ROCK1	0.51601150
70	GRK5	0.51070127
71	MAP2K3	0.48239165
72	PRKCG	0.48194478
73	PRKAA1	0.48132464
74	CHEK2	0.47059632
75	CSNK1A1	0.44570100
76	BMPR1B	0.42844972
77	RPS6KA3	0.42741224
78	RIPK1	0.42416039
79	RPS6KB1	0.42090379
80	SGK1	0.41594147
81	NUAK1	0.39955221
82	AKT1	0.39526519
83	EIF2AK2	0.39497379
84	JAK3	0.38443452
85	DDR2	0.37857029
86	CAMK4	0.37823903
87	PAK2	0.37131970
88	CAMK2A	0.36953798
89	MAPK8	0.36762603
90	CAMK2G	0.34765231
91	NME1	0.34447013
92	CDK14	0.34196602
93	RPS6KA1	0.33686139
94	TESK2	0.33577126
95	CDK11A	0.32537682
96	PLK2	0.32355072
97	BRSK1	0.31831369
98	CDK15	0.31091649
99	OBSCN	0.30388828
100	CDK18	0.30305685

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	4.62435989
2	Alcoholism_Homo sapiens_hsa05034	4.37931707
3	Morphine addiction_Homo sapiens_hsa05032	2.89001985
4	Nicotine addiction_Homo sapiens_hsa05033	2.83045893
5	GABAergic synapse_Homo sapiens_hsa04727	2.79581192
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.63228050
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.58783040
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.54002668
9	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.42848033
10	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.28966763
11	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.14422721
12	Dopaminergic synapse_Homo sapiens_hsa04728	2.07113130
13	Glutamatergic synapse_Homo sapiens_hsa04724	1.92669687
14	Circadian entrainment_Homo sapiens_hsa04713	1.71860966
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.71844649
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.69422596
17	Cocaine addiction_Homo sapiens_hsa05030	1.64499331
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.61384362
19	Viral carcinogenesis_Homo sapiens_hsa05203	1.57072493
20	Cholinergic synapse_Homo sapiens_hsa04725	1.52893984
21	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.44700962
22	Tight junction_Homo sapiens_hsa04530	1.44142217
23	Serotonergic synapse_Homo sapiens_hsa04726	1.37302794
24	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.32571026
25	mRNA surveillance pathway_Homo sapiens_hsa03015	1.29149477
26	Taste transduction_Homo sapiens_hsa04742	1.28255261
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.28135182
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.25655660
29	Spliceosome_Homo sapiens_hsa03040	1.23059168
30	Axon guidance_Homo sapiens_hsa04360	1.20640724
31	Insulin secretion_Homo sapiens_hsa04911	1.18909288
32	Gastric acid secretion_Homo sapiens_hsa04971	1.18687542
33	Hippo signaling pathway_Homo sapiens_hsa04390	1.14035321
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13946883
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13402058
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11685923
37	Basal cell carcinoma_Homo sapiens_hsa05217	1.10602871
38	Adherens junction_Homo sapiens_hsa04520	1.10460699
39	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.09435623
40	Vibrio cholerae infection_Homo sapiens_hsa05110	1.04784532
41	Renin secretion_Homo sapiens_hsa04924	1.02683420
42	Sulfur metabolism_Homo sapiens_hsa00920	1.00878509
43	Estrogen signaling pathway_Homo sapiens_hsa04915	0.95377003
44	Amphetamine addiction_Homo sapiens_hsa05031	0.94071676
45	Wnt signaling pathway_Homo sapiens_hsa04310	0.92017327
46	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.89853493
47	Melanogenesis_Homo sapiens_hsa04916	0.89579207
48	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.89080180
49	One carbon pool by folate_Homo sapiens_hsa00670	0.88156738
50	Sulfur relay system_Homo sapiens_hsa04122	0.86793294
51	Gap junction_Homo sapiens_hsa04540	0.84661255
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84276496
53	Regulation of autophagy_Homo sapiens_hsa04140	0.80750072
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.79003169
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74902570
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.73662460
57	Oocyte meiosis_Homo sapiens_hsa04114	0.72278332
58	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.70913601
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70694386
60	Circadian rhythm_Homo sapiens_hsa04710	0.69215044
61	Olfactory transduction_Homo sapiens_hsa04740	0.68317779
62	MAPK signaling pathway_Homo sapiens_hsa04010	0.66666882
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.65255715
64	Long-term depression_Homo sapiens_hsa04730	0.65069963
65	Salivary secretion_Homo sapiens_hsa04970	0.63850886
66	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.63705698
67	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.60751361
68	Phototransduction_Homo sapiens_hsa04744	0.60311562
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58351271
70	Huntingtons disease_Homo sapiens_hsa05016	0.56861555
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55480795
72	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.55365440
73	Parkinsons disease_Homo sapiens_hsa05012	0.55349491
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.53806930
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50565726
76	Long-term potentiation_Homo sapiens_hsa04720	0.49605871
77	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49193608
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.47530315
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.46592592
80	GnRH signaling pathway_Homo sapiens_hsa04912	0.44493113
81	Ras signaling pathway_Homo sapiens_hsa04014	0.41410173
82	Bile secretion_Homo sapiens_hsa04976	0.41303247
83	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.40917332
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40589715
85	Alzheimers disease_Homo sapiens_hsa05010	0.40357462
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39115351
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.38862775
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.37272747
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35328481
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35125785
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.32286460
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32026426
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31021586
94	Butanoate metabolism_Homo sapiens_hsa00650	0.30454966
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.29999919
96	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.29798254
97	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.28731639
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28681245
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27460279
100	Thyroid cancer_Homo sapiens_hsa05216	0.26691525

SCDP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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