SCEL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.69871745
2keratinization (GO:0031424)9.10045145
3hemidesmosome assembly (GO:0031581)7.27863426
4multicellular organismal water homeostasis (GO:0050891)7.05795069
5keratinocyte proliferation (GO:0043616)6.81037518
6* keratinocyte differentiation (GO:0030216)6.28194973
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.23536662
8molting cycle (GO:0042303)6.16761415
9hair cycle (GO:0042633)6.16761415
10water homeostasis (GO:0030104)5.98133666
11peptide cross-linking (GO:0018149)5.41140630
12sphingoid metabolic process (GO:0046519)5.36541983
13regulation of phospholipase A2 activity (GO:0032429)5.31683421
14sphingosine metabolic process (GO:0006670)5.30492373
15intermediate filament organization (GO:0045109)5.24382568
16* epidermal cell differentiation (GO:0009913)5.19186823
17keratinocyte development (GO:0003334)5.10176837
18gap junction assembly (GO:0016264)4.88516534
19diol metabolic process (GO:0034311)4.73561105
20* epidermis development (GO:0008544)4.72703346
21establishment of planar polarity (GO:0001736)4.70707713
22establishment of tissue polarity (GO:0007164)4.70707713
23negative regulation of keratinocyte proliferation (GO:0010839)4.66387873
24negative regulation of cell fate specification (GO:0009996)4.39019258
25regulation of ruffle assembly (GO:1900027)4.37166847
26lipoxygenase pathway (GO:0019372)4.31018640
27skin morphogenesis (GO:0043589)4.17754270
28interferon-gamma secretion (GO:0072643)4.03504310
29ectoderm development (GO:0007398)3.99917266
30linoleic acid metabolic process (GO:0043651)3.99277850
31regulation of cell proliferation involved in kidney development (GO:1901722)3.86550642
32membrane raft organization (GO:0031579)3.85039881
33negative regulation of cell fate commitment (GO:0010454)3.80981104
34atrioventricular valve morphogenesis (GO:0003181)3.78551399
35gland morphogenesis (GO:0022612)3.77862499
36chemical homeostasis within a tissue (GO:0048875)3.68676111
37viral transcription (GO:0019083)3.66651974
38plasma membrane repair (GO:0001778)3.61486206
39surfactant homeostasis (GO:0043129)3.58972136
40regulation of chemokine secretion (GO:0090196)3.54784616
41G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.54749807
42cardiac right ventricle morphogenesis (GO:0003215)3.52724009
43lateral sprouting from an epithelium (GO:0060601)3.52535701
44long-chain fatty acid biosynthetic process (GO:0042759)3.42451227
45positive regulation of hair cycle (GO:0042635)3.41404130
46positive regulation of hair follicle development (GO:0051798)3.41404130
47translational termination (GO:0006415)3.39838991
48regulation of hypersensitivity (GO:0002883)3.37232349
49hair cell differentiation (GO:0035315)3.34617769
50positive regulation of interleukin-8 secretion (GO:2000484)3.32328890
51phospholipid scrambling (GO:0017121)3.32135813
52lymph vessel development (GO:0001945)3.31651546
53phosphatidylserine acyl-chain remodeling (GO:0036150)3.29696424
54ventricular cardiac muscle cell action potential (GO:0086005)3.26968190
55detection of bacterium (GO:0016045)3.26815119
56regulation of glomerular filtration (GO:0003093)3.26782397
57positive regulation of p38MAPK cascade (GO:1900745)3.26681446
58regulation of cardioblast differentiation (GO:0051890)3.25907272
59glucosamine-containing compound catabolic process (GO:1901072)3.25616797
60polarized epithelial cell differentiation (GO:0030859)3.24667777
61ribosomal small subunit biogenesis (GO:0042274)3.22868911
62apical protein localization (GO:0045176)3.22845942
63epithelial cell differentiation involved in prostate gland development (GO:0060742)3.22197028
64positive regulation of epidermis development (GO:0045684)3.17952111
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.16956827
66regulation of keratinocyte differentiation (GO:0045616)3.14062875
67eyelid development in camera-type eye (GO:0061029)3.13578925
68positive regulation of epidermal cell differentiation (GO:0045606)3.09848567
69regulation of keratinocyte proliferation (GO:0010837)3.07603049
70planar cell polarity pathway involved in neural tube closure (GO:0090179)3.06499405
71intermediate filament cytoskeleton organization (GO:0045104)3.05076340
72regulation of transforming growth factor beta1 production (GO:0032908)3.04334155
73O-glycan processing (GO:0016266)3.03635628
74negative regulation of stress fiber assembly (GO:0051497)3.02707045
75regulation of cholesterol homeostasis (GO:2000188)3.02356975
76cell-substrate junction assembly (GO:0007044)3.01631439
77regulation of interleukin-8 secretion (GO:2000482)3.00567102
78hypotonic response (GO:0006971)2.97232225
79positive regulation of vesicle fusion (GO:0031340)2.96718258
80intermediate filament-based process (GO:0045103)2.95380919
81negative regulation of interleukin-2 production (GO:0032703)2.94478280
82lung lobe morphogenesis (GO:0060463)2.93629767
83heart valve morphogenesis (GO:0003179)2.89968153
84fatty acid elongation (GO:0030497)2.88749572
85dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.86241060
86phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81995368
87mesenchymal to epithelial transition (GO:0060231)2.81781274
88limb bud formation (GO:0060174)2.80907000
89regulation of hair follicle development (GO:0051797)2.80680293
90phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.80370402
91negative regulation of interferon-gamma production (GO:0032689)2.79837139
92cell-cell junction assembly (GO:0007043)2.78826521
93negative regulation of kidney development (GO:0090185)2.77746915
94detection of other organism (GO:0098543)2.76614347
95retinol metabolic process (GO:0042572)2.75966693
96regulation of epidermis development (GO:0045682)2.75886753
97positive regulation of chemokine secretion (GO:0090197)2.75155432
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74196709
99viral life cycle (GO:0019058)2.72274425
100hair follicle morphogenesis (GO:0031069)2.70763159
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67491560
102epithelial cell-cell adhesion (GO:0090136)2.66975690
103regulation of transforming growth factor beta2 production (GO:0032909)2.66944193
104renal system process involved in regulation of blood volume (GO:0001977)2.66823983
105cyclooxygenase pathway (GO:0019371)2.66565681
106negative regulation of T cell mediated immunity (GO:0002710)2.66485227
107glomerular visceral epithelial cell development (GO:0072015)2.66186721
108regulation of p38MAPK cascade (GO:1900744)2.66064441
109one-carbon compound transport (GO:0019755)2.65708015
110phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64712385
111protein targeting to ER (GO:0045047)2.64520532
112regulation of cell fate specification (GO:0042659)2.64129178
113neural crest cell development (GO:0014032)2.64081848
114endosome organization (GO:0007032)2.61763349
115cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.61225294
116cotranslational protein targeting to membrane (GO:0006613)2.60612748
117establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60230346
118asymmetric protein localization (GO:0008105)2.58324985
119protein localization to endosome (GO:0036010)2.57407276
120negative regulation of acute inflammatory response (GO:0002674)2.57254936
121wound healing (GO:0042060)2.57108706
122* epithelium development (GO:0060429)2.56799880
123regulation of hair cycle (GO:0042634)2.55572946
124translational elongation (GO:0006414)2.54537095
125* epithelial cell differentiation (GO:0030855)2.52876143
126positive regulation of keratinocyte differentiation (GO:0045618)2.52861951
127positive regulation of odontogenesis (GO:0042482)2.51684589
128positive regulation of glomerulus development (GO:0090193)2.51648301
129regulation of apoptotic process involved in morphogenesis (GO:1902337)2.51154579
130intestinal epithelial cell development (GO:0060576)2.50877764
131hair cycle process (GO:0022405)2.50397252
132molting cycle process (GO:0022404)2.50397252
133cellular protein complex disassembly (GO:0043624)2.49830350
134G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.49099852
135smooth muscle tissue development (GO:0048745)2.49043955
136non-canonical Wnt signaling pathway (GO:0035567)2.47777277
137face development (GO:0060324)2.47560427
138negative regulation of stem cell proliferation (GO:2000647)2.45461468
139regulation of epidermal cell differentiation (GO:0045604)2.44608978
140positive regulation of transforming growth factor beta production (GO:0071636)2.44094915
141regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44064121
142prostaglandin biosynthetic process (GO:0001516)2.43320066
143prostanoid biosynthetic process (GO:0046457)2.43320066
144negative regulation of complement activation (GO:0045916)2.40531768
145regulation of transforming growth factor beta production (GO:0071634)2.40188770
146phosphatidylcholine acyl-chain remodeling (GO:0036151)2.39225704
147regulation of heart rate by cardiac conduction (GO:0086091)2.36200561
148polyol transport (GO:0015791)2.34090788
149icosanoid secretion (GO:0032309)2.34026748
150arachidonic acid secretion (GO:0050482)2.34026748
151fibrinolysis (GO:0042730)2.33620263
152epithelial cell proliferation (GO:0050673)2.29434631
153desmosome organization (GO:0002934)15.1367007
154establishment of skin barrier (GO:0061436)10.2733268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.74500480
2* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.96975072
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.77782635
4P63_26484246_Chip-Seq_KERATINOCYTES_Human2.58224482
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.57603835
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33044906
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26647563
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.05765415
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01587820
10TP63_17297297_ChIP-ChIP_HaCaT_Human14.1315568
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94155292
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94155292
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89073083
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.73654197
15* SOX2_20726797_ChIP-Seq_SW620_Human1.54208883
16TCF4_18268006_ChIP-ChIP_LS174T_Human1.50586064
17AR_21572438_ChIP-Seq_LNCaP_Human1.47541493
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47192707
19* CJUN_26792858_Chip-Seq_BT549_Human1.46120835
20ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46033408
21* TP63_23658742_ChIP-Seq_EP156T_Human1.44871812
22ZNF263_19887448_ChIP-Seq_K562_Human1.38302098
23TP53_18474530_ChIP-ChIP_U2OS_Human1.38292826
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33363648
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31853189
26AHR_22903824_ChIP-Seq_MCF-7_Human1.30924836
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28983444
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25531736
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22733207
30* KLF5_25053715_ChIP-Seq_YYC3_Human1.22202447
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21488656
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21043172
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.18509979
34GATA1_22025678_ChIP-Seq_K562_Human1.16381570
35CLOCK_20551151_ChIP-Seq_293T_Human1.15549392
36BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12787276
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09662081
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09507084
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08890870
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08829641
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06777648
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.06697524
43TP63_22573176_ChIP-Seq_HFKS_Human1.05594448
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05241415
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.05208503
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04914222
47GATA4_25053715_ChIP-Seq_YYC3_Human1.04790360
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04617936
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04576569
50BCAT_22108803_ChIP-Seq_LS180_Human1.03254635
51* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01452608
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.00934311
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.00118794
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.00064754
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99872042
56ARNT_22903824_ChIP-Seq_MCF-7_Human0.99589799
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97772259
58* RXR_22108803_ChIP-Seq_LS180_Human0.97724958
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97300601
60EP300_21415370_ChIP-Seq_HL-1_Mouse0.97024883
61HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96878268
62BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96060481
63RACK7_27058665_Chip-Seq_MCF-7_Human0.95129090
64UBF1/2_26484160_Chip-Seq_HMECs_Human0.94640553
65TP53_16413492_ChIP-PET_HCT116_Human0.94117097
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94040270
67* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92953518
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91798869
69JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90625090
70* TBX20_22328084_ChIP-Seq_HEART_Mouse0.89868394
71* TBX20_22080862_ChIP-Seq_HEART_Mouse0.89868394
72AR_21909140_ChIP-Seq_LNCAP_Human0.89816426
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89241794
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88891701
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88068017
76EZH2_27294783_Chip-Seq_ESCs_Mouse0.87573157
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87499301
78BRD4_25478319_ChIP-Seq_HGPS_Human0.87199473
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87143908
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86922419
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85893320
82NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85241431
83RNF2_27304074_Chip-Seq_ESCs_Mouse0.84683441
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84339565
85FOXA1_25552417_ChIP-Seq_VCAP_Human0.82947219
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.82720953
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82466846
88* GATA6_25053715_ChIP-Seq_YYC3_Human0.81492358
89* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81183200
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.81156880
91RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81046419
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81046419
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80859369
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80670367
95SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80183035
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80079893
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79974386
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.79916505
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.79805428
100* SMAD3_21741376_ChIP-Seq_HESCs_Human0.78913708
101JARID2_20064375_ChIP-Seq_MESCs_Mouse0.78313780
102TCF4_22108803_ChIP-Seq_LS180_Human0.78027778
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.76468612
104ATF3_27146783_Chip-Seq_COLON_Human0.76426846
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76314072
106CBX2_27304074_Chip-Seq_ESCs_Mouse0.75859446
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75227293
108FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75026209
109* CDX2_22108803_ChIP-Seq_LS180_Human0.74662974
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.74481758
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74062052
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73528460
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73161774
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72640163
115P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.70466957
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.70332489
117LXR_22158963_ChIP-Seq_LIVER_Mouse0.70235607
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69675309
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.69505107
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68986829
121GATA6_21074721_ChIP-Seq_CACO-2_Human0.68022474
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.66089172
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65694304
124EGR1_19032775_ChIP-ChIP_M12_Human0.64848987
125* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64694957
126* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64694957
127* CEBPB_22108803_ChIP-Seq_LS180_Human0.63796338
128ELF5_23300383_ChIP-Seq_T47D_Human0.63241048
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.62941260
130VDR_22108803_ChIP-Seq_LS180_Human0.62930349
131EGR1_23403033_ChIP-Seq_LIVER_Mouse0.62759131
132PPARA_22158963_ChIP-Seq_LIVER_Mouse0.62564540
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.62547151
134FOXA2_19822575_ChIP-Seq_HepG2_Human0.62462967
135SALL4_18804426_ChIP-ChIP_XEN_Mouse0.61952790
136CTCF_27219007_Chip-Seq_Bcells_Human0.61465651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.20477356
2MP0010234_abnormal_vibrissa_follicle5.64978013
3MP0003941_abnormal_skin_development5.01639041
4MP0005275_abnormal_skin_tensile4.86247917
5MP0005501_abnormal_skin_physiology4.38918527
6MP0004381_abnormal_hair_follicle4.06951075
7MP0000579_abnormal_nail_morphology3.62895087
8MP0002098_abnormal_vibrissa_morphology3.44408790
9MP0002060_abnormal_skin_morphology3.39785552
10MP0000383_abnormal_hair_follicle3.39190966
11MP0001216_abnormal_epidermal_layer3.35194862
12MP0010678_abnormal_skin_adnexa3.27910441
13MP0002254_reproductive_system_inflammat3.07418088
14MP0003453_abnormal_keratinocyte_physiol2.96461622
15MP0000647_abnormal_sebaceous_gland2.94747263
16MP0010771_integument_phenotype2.84803065
17MP0000377_abnormal_hair_follicle2.67200202
18MP0000566_synostosis2.59061906
19MP0003705_abnormal_hypodermis_morpholog2.36536803
20MP0000467_abnormal_esophagus_morphology2.23903492
21MP0000427_abnormal_hair_cycle2.17247171
22MP0004947_skin_inflammation2.16463923
23MP0003566_abnormal_cell_adhesion2.09196703
24MP0000762_abnormal_tongue_morphology1.96330515
25MP0001346_abnormal_lacrimal_gland1.91881779
26MP0005451_abnormal_body_composition1.90571466
27MP0002009_preneoplasia1.90367455
28MP0001191_abnormal_skin_condition1.64423809
29MP0009931_abnormal_skin_appearance1.57402726
30MP0003136_yellow_coat_color1.54764115
31MP0009780_abnormal_chondrocyte_physiolo1.53159925
32MP0008438_abnormal_cutaneous_collagen1.52807688
33MP0001958_emphysema1.47523897
34MP0001188_hyperpigmentation1.47349142
35MP0001851_eye_inflammation1.44840218
36MP0009379_abnormal_foot_pigmentation1.41201997
37MP0000367_abnormal_coat/_hair1.40489320
38MP0004185_abnormal_adipocyte_glucose1.39942359
39MP0001243_abnormal_dermal_layer1.30111265
40MP0001340_abnormal_eyelid_morphology1.15145497
41MP0002234_abnormal_pharynx_morphology1.13542503
42MP0004782_abnormal_surfactant_physiolog1.09886328
43MP0000537_abnormal_urethra_morphology1.08904905
44MP0002877_abnormal_melanocyte_morpholog1.08452976
45MP0000465_gastrointestinal_hemorrhage1.07236253
46MP0010352_gastrointestinal_tract_polyps1.04776729
47MP0009384_cardiac_valve_regurgitation0.97608421
48MP0010030_abnormal_orbit_morphology0.95346434
49MP0004043_abnormal_pH_regulation0.94474148
50MP0005409_darkened_coat_color0.94072266
51MP0004019_abnormal_vitamin_homeostasis0.93885553
52MP0002249_abnormal_larynx_morphology0.92847911
53MP0003011_delayed_dark_adaptation0.90904355
54MP0004885_abnormal_endolymph0.85491820
55MP0009053_abnormal_anal_canal0.84489037
56MP0005377_hearing/vestibular/ear_phenot0.83758681
57MP0003878_abnormal_ear_physiology0.83758681
58MP0000015_abnormal_ear_pigmentation0.82627042
59MP0005023_abnormal_wound_healing0.81879949
60MP0005367_renal/urinary_system_phenotyp0.80551493
61MP0000516_abnormal_urinary_system0.80551493
62MP0005503_abnormal_tendon_morphology0.78685730
63MP0005174_abnormal_tail_pigmentation0.78068391
64MP0000627_abnormal_mammary_gland0.76529279
65MP0005076_abnormal_cell_differentiation0.75754753
66MP0003315_abnormal_perineum_morphology0.73272854
67MP0004272_abnormal_basement_membrane0.70167807
68MP0003191_abnormal_cellular_cholesterol0.67444060
69MP0005187_abnormal_penis_morphology0.66857927
70MP0002006_tumorigenesis0.66684887
71MP0008789_abnormal_olfactory_epithelium0.66391654
72MP0002282_abnormal_trachea_morphology0.65474386
73MP0003755_abnormal_palate_morphology0.65452937
74MP0001542_abnormal_bone_strength0.63683370
75MP0002233_abnormal_nose_morphology0.62255132
76MP0001849_ear_inflammation0.61972918
77MP0005164_abnormal_response_to0.61734281
78MP0002277_abnormal_respiratory_mucosa0.60390829
79MP0002177_abnormal_outer_ear0.60012338
80MP0005508_abnormal_skeleton_morphology0.59211758
81MP0002132_abnormal_respiratory_system0.58699829
82MP0008004_abnormal_stomach_pH0.57987948
83MP0001784_abnormal_fluid_regulation0.57912945
84MP0002166_altered_tumor_susceptibility0.55788754
85MP0009250_abnormal_appendicular_skeleto0.55241554
86MP0002095_abnormal_skin_pigmentation0.52008662
87MP0004264_abnormal_extraembryonic_tissu0.51736083
88MP0003950_abnormal_plasma_membrane0.51450546
89MP0005171_absent_coat_pigmentation0.50798119
90MP0000003_abnormal_adipose_tissue0.50668899
91MP0000372_irregular_coat_pigmentation0.50101898
92MP0003828_pulmonary_edema0.49352420
93MP0005248_abnormal_Harderian_gland0.49001914
94MP0000371_diluted_coat_color0.48852299
95MP0008961_abnormal_basal_metabolism0.48236835
96MP0005375_adipose_tissue_phenotype0.46111426
97MP0003300_gastrointestinal_ulcer0.45649608
98MP0005083_abnormal_biliary_tract0.44562767
99MP0000538_abnormal_urinary_bladder0.44477936
100MP0000613_abnormal_salivary_gland0.44335226
101MP0000470_abnormal_stomach_morphology0.42632865
102MP0003763_abnormal_thymus_physiology0.42589281
103MP0005197_abnormal_uvea_morphology0.41844584
104MP0005666_abnormal_adipose_tissue0.41114015
105MP0010368_abnormal_lymphatic_system0.40980943
106MP0003091_abnormal_cell_migration0.40526160
107MP0002090_abnormal_vision0.40156619
108MP0005499_abnormal_olfactory_system0.39424294
109MP0005394_taste/olfaction_phenotype0.39424294
110MP0000432_abnormal_head_morphology0.38471679
111MP0006138_congestive_heart_failure0.38303032
112MP0006054_spinal_hemorrhage0.36992876
113MP0000678_abnormal_parathyroid_gland0.36693903
114MP0002332_abnormal_exercise_endurance0.36350613
115MP0002111_abnormal_tail_morphology0.35423113
116MP0001984_abnormal_olfaction0.35293867
117MP0005193_abnormal_anterior_eye0.35145109
118MP0008995_early_reproductive_senescence0.34456263
119MP0001765_abnormal_ion_homeostasis0.34076975
120MP0001177_atelectasis0.33287524
121MP0001853_heart_inflammation0.33003127
122MP0001879_abnormal_lymphatic_vessel0.30765772
123MP0003638_abnormal_response/metabolism_0.30720747
124MP0003436_decreased_susceptibility_to0.30584808
125MP0005388_respiratory_system_phenotype0.30423312
126MP0002133_abnormal_respiratory_system0.30423312
127MP0003938_abnormal_ear_development0.30402741
128MP0004883_abnormal_blood_vessel0.28807943
129MP0005075_abnormal_melanosome_morpholog0.28452419
130MP0004484_altered_response_of0.28348688
131MP0001186_pigmentation_phenotype0.27526202
132MP0003786_premature_aging0.26163417
133MP0005165_increased_susceptibility_to0.25439489
134MP0002136_abnormal_kidney_physiology0.25269899
135MP0003045_fibrosis0.24209880
136MP0000858_altered_metastatic_potential0.23741792

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.77061734
2Lip pit (HP:0100267)6.18754397
3Right ventricular cardiomyopathy (HP:0011663)6.13293475
4Plantar hyperkeratosis (HP:0007556)6.10869123
5Woolly hair (HP:0002224)6.08627747
6Parakeratosis (HP:0001036)5.97888530
7Increased IgE level (HP:0003212)5.85667789
8Fragile nails (HP:0001808)5.63736198
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.53447765
10Onycholysis (HP:0001806)5.52113898
11Palmoplantar hyperkeratosis (HP:0000972)5.44180422
12Congenital ichthyosiform erythroderma (HP:0007431)5.42505647
13Palmar hyperkeratosis (HP:0010765)5.13693132
14Oral leukoplakia (HP:0002745)5.02842474
15Abnormality of nail color (HP:0100643)4.82133950
16Erythema (HP:0010783)4.48705430
17Milia (HP:0001056)4.19221665
18Erythroderma (HP:0001019)4.11523920
19Abnormal blistering of the skin (HP:0008066)3.84571515
20Pili torti (HP:0003777)3.71056494
21Natal tooth (HP:0000695)3.66991449
22Abnormality of secondary sexual hair (HP:0009888)3.63237301
23Abnormality of the axillary hair (HP:0100134)3.63237301
24Popliteal pterygium (HP:0009756)3.56928636
25Sparse scalp hair (HP:0002209)3.56473250
26Nail dystrophy (HP:0008404)3.43739897
27Sparse eyelashes (HP:0000653)3.37842218
28Thick nail (HP:0001805)3.33944503
29Acanthosis nigricans (HP:0000956)3.33339921
30Advanced eruption of teeth (HP:0006288)3.28384687
31Corneal erosion (HP:0200020)3.20101333
32Absent eyelashes (HP:0000561)3.19548283
33Dry hair (HP:0011359)3.14648840
34Concave nail (HP:0001598)3.08532137
35Ventricular tachycardia (HP:0004756)3.03610110
36Distal lower limb muscle weakness (HP:0009053)3.00652367
37Curly hair (HP:0002212)3.00150407
38Hypohidrosis (HP:0000966)2.99261906
39Interstitial pulmonary disease (HP:0006530)2.96753494
40Ectropion (HP:0000656)2.95932055
41Conjunctival hamartoma (HP:0100780)2.94107321
42Duplicated collecting system (HP:0000081)2.83824769
43Oligodontia (HP:0000677)2.83565260
44Hyporeflexia of lower limbs (HP:0002600)2.75536210
45Hypoplastic labia majora (HP:0000059)2.74656712
46Aplasia cutis congenita (HP:0001057)2.71463866
47Pruritus (HP:0000989)2.70110769
48Palmoplantar keratoderma (HP:0000982)2.64480910
49Gangrene (HP:0100758)2.63515689
50Eczematoid dermatitis (HP:0000976)2.62394375
51Atrophic scars (HP:0001075)2.60828849
52Absent eyebrow (HP:0002223)2.54518990
53Abnormality of the labia majora (HP:0012881)2.49586017
54Hamartoma of the eye (HP:0010568)2.47778023
55Abnormality of the renal collecting system (HP:0004742)2.46117747
56Alopecia of scalp (HP:0002293)2.42308910
57Abnormal hemoglobin (HP:0011902)2.41859872
58Ridged nail (HP:0001807)2.41543009
59Absent hair (HP:0002298)2.40104209
60Abnormality of the gastric mucosa (HP:0004295)2.36813718
61Abnormality of permanent molar morphology (HP:0011071)2.36203960
62Abnormality of the dental root (HP:0006486)2.36203960
63Taurodontia (HP:0000679)2.36203960
64Slow-growing hair (HP:0002217)2.33044751
65Abnormality of hair growth rate (HP:0011363)2.33044751
66Selective tooth agenesis (HP:0001592)2.32434014
67Brittle hair (HP:0002299)2.31404897
68Anhidrosis (HP:0000970)2.29829482
69Aplasia involving bones of the upper limbs (HP:0009823)2.26427488
70Aplasia of the phalanges of the hand (HP:0009802)2.26427488
71Aplasia involving bones of the extremities (HP:0009825)2.26427488
72Abnormal hair laboratory examination (HP:0003328)2.25216218
73Hypoplasia of dental enamel (HP:0006297)2.24796347
74Abnormality of molar (HP:0011077)2.22517150
75Abnormality of molar morphology (HP:0011070)2.22517150
76Abnormality of the salivary glands (HP:0010286)2.22025049
77Melanocytic nevus (HP:0000995)2.18576551
78Abnormality of the dental pulp (HP:0006479)2.14748541
79Hypodontia (HP:0000668)2.12858439
80Abnormality of cells of the erythroid lineage (HP:0012130)2.10706207
81Pterygium (HP:0001059)2.09080145
82Hyperkalemia (HP:0002153)2.08038077
83Villous atrophy (HP:0011473)2.04599451
84Abnormality of small intestinal villus morphology (HP:0011472)2.04599451
85Dehydration (HP:0001944)2.03293832
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.01302515
87Osteolytic defects of the hand bones (HP:0009699)2.01302515
88Skin pits (HP:0100276)2.01004297
89Ventricular fibrillation (HP:0001663)2.00113859
90Blepharitis (HP:0000498)1.97523355
91Synostosis involving the elbow (HP:0003938)1.94010183
92Humeroradial synostosis (HP:0003041)1.94010183
93Conical tooth (HP:0000698)1.93367878
94Lack of skin elasticity (HP:0100679)1.90803782
95Nasolacrimal duct obstruction (HP:0000579)1.89862230
96Down-sloping shoulders (HP:0200021)1.89656343
97Xerostomia (HP:0000217)1.88451833
98Furrowed tongue (HP:0000221)1.88437362
99Congenital, generalized hypertrichosis (HP:0004540)1.88388779
100Ureteral duplication (HP:0000073)1.87611887
101Abnormal sex determination (HP:0012244)1.87510979
102Sex reversal (HP:0012245)1.87510979
103Dry skin (HP:0000958)1.86820709
104Abnormality of the neuromuscular junction (HP:0003398)1.85755540
105Fatigable weakness (HP:0003473)1.85755540
106Neonatal death (HP:0003811)1.84960542
107Bifid scrotum (HP:0000048)1.83983903
108Hyperhidrosis (HP:0000975)1.79752075
109Labial hypoplasia (HP:0000066)1.79360763
110Split foot (HP:0001839)1.78105448
111Laryngomalacia (HP:0001601)1.76641135
112Abnormality of the lacrimal duct (HP:0011481)1.75941715
113Fine hair (HP:0002213)1.74451471
114Pustule (HP:0200039)1.73105776
115Severe Myopia (HP:0011003)1.72724281
116Abnormal number of erythroid precursors (HP:0012131)1.71709240
117Amniotic constriction ring (HP:0009775)1.71699126
118Abnormality of placental membranes (HP:0011409)1.71699126
119Corneal dystrophy (HP:0001131)1.70623034
120Areflexia of lower limbs (HP:0002522)1.70066380
121Coarse hair (HP:0002208)1.69978099
122Enlarged epiphyses (HP:0010580)1.67879620
123Increased connective tissue (HP:0009025)1.67878640
124Reticulocytopenia (HP:0001896)1.67604724
125Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.66863380
126Ulnar claw (HP:0001178)1.66052908
127Reduced subcutaneous adipose tissue (HP:0003758)1.64790952
128Hypergammaglobulinemia (HP:0010702)1.64506733
129Abnormality of the distal phalanges of the toes (HP:0010182)1.64056527
130Hyperactive renin-angiotensin system (HP:0000841)1.63863155
131Congenital malformation of the right heart (HP:0011723)1.63257948
132Double outlet right ventricle (HP:0001719)1.63257948
133Fragile skin (HP:0001030)1.62118953
134Malignant hyperthermia (HP:0002047)1.61985537
135Decreased lacrimation (HP:0000633)1.61720537
136Hypoplastic female external genitalia (HP:0012815)1.61375361
137Abnormal auditory evoked potentials (HP:0006958)1.61069890
138Thin bony cortex (HP:0002753)1.61017148
139Hamartoma (HP:0010566)1.59573133
140Premature loss of primary teeth (HP:0006323)1.59145255
141Widely patent fontanelles and sutures (HP:0004492)1.57528094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.21001485
2MST44.43346813
3MAPKAPK34.32353929
4EPHB23.99763037
5MAP3K33.55758773
6FER3.21611622
7MAP3K22.74996727
8TRPM72.56222681
9LATS12.35134829
10RPS6KB22.02916751
11STK102.01193457
12ERN11.96766238
13EPHA31.92606832
14LRRK21.85892177
15BCR1.77692371
16ERBB31.72410242
17STK241.72241036
18PIK3CG1.71095871
19MET1.71003897
20FGFR21.67041153
21TGFBR21.61094099
22FGFR11.60047138
23MAP3K121.44064685
24BMPR1B1.36964859
25MAPKAPK51.36128392
26MAPK151.24971284
27GRK11.21102959
28FGFR41.20109857
29EPHA21.19555343
30WNK11.19291370
31BMX1.14814501
32IRAK31.13887004
33MAPK71.13074883
34GRK71.13061349
35PBK1.12449652
36CDK31.11774004
37MAP3K11.08082009
38PDGFRB1.07911301
39EEF2K1.05321591
40PTK61.04577218
41TAOK10.97683789
42PIM20.97592016
43FGFR30.96951404
44EPHB10.95935349
45LMTK20.94578311
46CDK60.91220825
47DAPK20.87968078
48HIPK20.87924603
49NEK90.85200331
50MOS0.84731879
51BRSK20.81589199
52PRKD10.80569889
53MAP3K90.79350447
54CASK0.78164169
55SGK30.77261455
56FRK0.76744930
57ERBB40.75559872
58NME10.74723516
59BLK0.73626947
60DYRK1B0.73304701
61LATS20.72115150
62NTRK20.71766264
63RPS6KA40.70002133
64MAPKAPK20.68498054
65DMPK0.67844716
66EPHA40.67757049
67TYK20.65260044
68SGK4940.65021981
69SGK2230.65021981
70SGK20.63993601
71RIPK10.63276027
72MAP3K130.62630255
73STK38L0.62553906
74ERBB20.59644276
75MAP3K140.59229637
76PDGFRA0.58884901
77MAP2K20.57049876
78TTN0.55807282
79PAK40.54777650
80STK380.51117774
81RPS6KB10.50170745
82PRKCE0.50074456
83IGF1R0.49583274
84IKBKB0.48330354
85GRK50.47887363
86JAK20.47482948
87MAP2K60.47344681
88STK30.46186311
89MAP3K60.45495106
90MAPK120.45493715
91TGFBR10.45478377
92OBSCN0.45216474
93ROCK10.44846845
94NLK0.44644841
95GSK3A0.44212831
96MYLK0.43855734
97BMPR20.43206113
98EIF2AK30.42920313
99PTK20.42737728
100TIE10.42733689
101MTOR0.42548083
102TESK10.41994957
103MAP2K10.41760085
104ADRBK10.41607178
105MAP3K70.41176046
106EIF2AK20.39362167
107RET0.38576141
108CSNK1D0.37394415
109OXSR10.37385037
110STK390.36491197
111ILK0.36342007
112IKBKE0.35098465
113ITK0.34484478
114CHUK0.34356289
115CDK190.34137261
116PRKAA20.33700941
117MAP3K110.33380886
118RPS6KA10.33090306
119MARK20.32995464
120PRKCI0.30307939
121MUSK0.30179258
122ABL10.29939639
123RIPK40.29613461
124STK110.28885593
125CSK0.28670966
126HCK0.27658303
127TRIB30.27183170
128IRAK10.26783712
129EGFR0.24674434
130PKN10.24104633
131RPS6KA20.23969384
132FLT30.22688334
133NEK60.22306414
134YES10.21940299
135CDC42BPA0.21292194
136SIK10.18734695
137ABL20.17366839
138SGK10.16698261
139MELK0.16142285
140AKT20.15379814
141FGR0.13682582
142JAK10.13418896

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.60783586
2Sphingolipid metabolism_Homo sapiens_hsa006002.81519472
3Ribosome_Homo sapiens_hsa030102.63746269
4Linoleic acid metabolism_Homo sapiens_hsa005912.40710218
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36988468
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30607614
7Basal cell carcinoma_Homo sapiens_hsa052172.14899406
8Arachidonic acid metabolism_Homo sapiens_hsa005902.10579519
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91194170
10Phenylalanine metabolism_Homo sapiens_hsa003601.83111608
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81774429
12Retinol metabolism_Homo sapiens_hsa008301.80733680
13Adherens junction_Homo sapiens_hsa045201.71211227
14Histidine metabolism_Homo sapiens_hsa003401.59964939
15ECM-receptor interaction_Homo sapiens_hsa045121.56914296
16Tight junction_Homo sapiens_hsa045301.56668086
17Hippo signaling pathway_Homo sapiens_hsa043901.53840438
18Chemical carcinogenesis_Homo sapiens_hsa052041.51235191
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50716213
20Axon guidance_Homo sapiens_hsa043601.48904268
21Fatty acid elongation_Homo sapiens_hsa000621.48316253
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47308994
23Melanogenesis_Homo sapiens_hsa049161.46108811
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40136704
25Ether lipid metabolism_Homo sapiens_hsa005651.39381596
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37469153
27Renal cell carcinoma_Homo sapiens_hsa052111.32331657
28TGF-beta signaling pathway_Homo sapiens_hsa043501.28714899
29Proteoglycans in cancer_Homo sapiens_hsa052051.28432032
30Phototransduction_Homo sapiens_hsa047441.17572572
31Bladder cancer_Homo sapiens_hsa052191.16940480
32Choline metabolism in cancer_Homo sapiens_hsa052311.16667232
33Renin secretion_Homo sapiens_hsa049241.16659782
34Hedgehog signaling pathway_Homo sapiens_hsa043401.15753103
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.14407108
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13142808
37p53 signaling pathway_Homo sapiens_hsa041151.09491675
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06855542
39Tyrosine metabolism_Homo sapiens_hsa003501.06801418
40Amoebiasis_Homo sapiens_hsa051461.05909180
41MicroRNAs in cancer_Homo sapiens_hsa052061.05491651
42VEGF signaling pathway_Homo sapiens_hsa043701.05076745
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.03259490
44Mineral absorption_Homo sapiens_hsa049781.01897085
45GnRH signaling pathway_Homo sapiens_hsa049120.98078782
46Wnt signaling pathway_Homo sapiens_hsa043100.97865167
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.94273589
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91298123
49Ras signaling pathway_Homo sapiens_hsa040140.90305052
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89140528
51Pancreatic cancer_Homo sapiens_hsa052120.88339476
52Complement and coagulation cascades_Homo sapiens_hsa046100.87141021
53Pancreatic secretion_Homo sapiens_hsa049720.84771473
54Thyroid cancer_Homo sapiens_hsa052160.83685356
55Dorso-ventral axis formation_Homo sapiens_hsa043200.81398494
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80627097
57Rap1 signaling pathway_Homo sapiens_hsa040150.79614187
58Pertussis_Homo sapiens_hsa051330.78428124
59Fatty acid biosynthesis_Homo sapiens_hsa000610.77269400
60Gastric acid secretion_Homo sapiens_hsa049710.76623153
61Melanoma_Homo sapiens_hsa052180.76201485
62Hepatitis C_Homo sapiens_hsa051600.74712366
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.72756398
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71345480
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71338711
66Glutathione metabolism_Homo sapiens_hsa004800.70377093
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.70315090
68Protein digestion and absorption_Homo sapiens_hsa049740.69666148
69Salmonella infection_Homo sapiens_hsa051320.69647430
70Salivary secretion_Homo sapiens_hsa049700.68534674
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68085306
72PPAR signaling pathway_Homo sapiens_hsa033200.67933373
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67927130
74Circadian rhythm_Homo sapiens_hsa047100.66592069
75Toxoplasmosis_Homo sapiens_hsa051450.66532765
76ABC transporters_Homo sapiens_hsa020100.66026727
77Graft-versus-host disease_Homo sapiens_hsa053320.65660688
78Ovarian steroidogenesis_Homo sapiens_hsa049130.65420585
79Endometrial cancer_Homo sapiens_hsa052130.65221416
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.62790375
81Small cell lung cancer_Homo sapiens_hsa052220.62649356
82Serotonergic synapse_Homo sapiens_hsa047260.61318022
83Platelet activation_Homo sapiens_hsa046110.61297582
84Focal adhesion_Homo sapiens_hsa045100.59942553
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59768356
86Influenza A_Homo sapiens_hsa051640.59271789
87Lysosome_Homo sapiens_hsa041420.58992901
88Staphylococcus aureus infection_Homo sapiens_hsa051500.58822158
89Malaria_Homo sapiens_hsa051440.57741786
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56907027
91Estrogen signaling pathway_Homo sapiens_hsa049150.56418363
92Pathways in cancer_Homo sapiens_hsa052000.56035277
93ErbB signaling pathway_Homo sapiens_hsa040120.55619943
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54867491
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54122989
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52862471
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.51784650
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51482285
99Prostate cancer_Homo sapiens_hsa052150.48971522
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48869747
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48866078
102Notch signaling pathway_Homo sapiens_hsa043300.47945891
103Phagosome_Homo sapiens_hsa041450.47878715
104Endocytosis_Homo sapiens_hsa041440.47592648
105Insulin signaling pathway_Homo sapiens_hsa049100.46224535
106Long-term depression_Homo sapiens_hsa047300.45845975
107Hematopoietic cell lineage_Homo sapiens_hsa046400.44955882
108TNF signaling pathway_Homo sapiens_hsa046680.44190749
109Fat digestion and absorption_Homo sapiens_hsa049750.44190403
110Osteoclast differentiation_Homo sapiens_hsa043800.42820062
111Acute myeloid leukemia_Homo sapiens_hsa052210.41818516
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40426995
113Caffeine metabolism_Homo sapiens_hsa002320.40259970
114Viral myocarditis_Homo sapiens_hsa054160.40232992
115cAMP signaling pathway_Homo sapiens_hsa040240.39951007
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39818787
117Collecting duct acid secretion_Homo sapiens_hsa049660.39760826
118beta-Alanine metabolism_Homo sapiens_hsa004100.39439738
119Glioma_Homo sapiens_hsa052140.39361268
120T cell receptor signaling pathway_Homo sapiens_hsa046600.38670788
121Inositol phosphate metabolism_Homo sapiens_hsa005620.38660263
122Asthma_Homo sapiens_hsa053100.36673796
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36619479
124Autoimmune thyroid disease_Homo sapiens_hsa053200.35795327
125Tuberculosis_Homo sapiens_hsa051520.35010847

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