SCFD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.26892789
2thrombin receptor signaling pathway (GO:0070493)6.50224356
3platelet aggregation (GO:0070527)5.50072539
4regulation of integrin-mediated signaling pathway (GO:2001044)5.44690790
5regulation of platelet activation (GO:0010543)5.15767023
6negative regulation of thymocyte apoptotic process (GO:0070244)5.00464938
7negative regulation of homotypic cell-cell adhesion (GO:0034111)4.80265688
8superoxide anion generation (GO:0042554)4.74121118
9keratinocyte development (GO:0003334)4.62712868
10regulation of integrin activation (GO:0033623)4.52211419
11regulation of Golgi to plasma membrane protein transport (GO:0042996)4.48102423
12mitochondrial calcium ion transport (GO:0006851)4.45038491
13blood coagulation, intrinsic pathway (GO:0007597)4.30602949
14platelet degranulation (GO:0002576)4.25496246
15negative regulation of platelet activation (GO:0010544)4.21145396
16positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.17234674
17extracellular fibril organization (GO:0043206)4.01173731
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.97341223
19adenosine receptor signaling pathway (GO:0001973)3.91812395
20positive regulation of macrophage differentiation (GO:0045651)3.90659550
21presynaptic membrane assembly (GO:0097105)3.85067013
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.84573425
23negative regulation of heart rate (GO:0010459)3.78636840
24megakaryocyte development (GO:0035855)3.78540674
25lipoxygenase pathway (GO:0019372)3.77718851
26righting reflex (GO:0060013)3.77708732
27negative regulation of keratinocyte proliferation (GO:0010839)3.75444714
28G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.74106103
29leukocyte migration involved in inflammatory response (GO:0002523)3.72058720
30regulation of homotypic cell-cell adhesion (GO:0034110)3.68448442
31negative regulation of protein localization to plasma membrane (GO:1903077)3.68187322
32homotypic cell-cell adhesion (GO:0034109)3.67077126
33platelet formation (GO:0030220)3.65298716
34negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.57319022
35eosinophil chemotaxis (GO:0048245)3.53669379
36presynaptic membrane organization (GO:0097090)3.53369993
37positive regulation of calcium ion import (GO:0090280)3.51375445
38positive regulation of endothelial cell differentiation (GO:0045603)3.50053725
39negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.45817163
40beta-amyloid metabolic process (GO:0050435)3.45570164
41purinergic nucleotide receptor signaling pathway (GO:0035590)3.45122131
42platelet activation (GO:0030168)3.43879362
43negative regulation of norepinephrine secretion (GO:0010700)3.42506251
44polyketide metabolic process (GO:0030638)3.39798383
45doxorubicin metabolic process (GO:0044598)3.39798383
46daunorubicin metabolic process (GO:0044597)3.39798383
47polyamine biosynthetic process (GO:0006596)3.37754869
48deoxyribose phosphate biosynthetic process (GO:0046385)3.37328195
492-deoxyribonucleotide biosynthetic process (GO:0009265)3.37328195
50angiogenesis involved in wound healing (GO:0060055)3.34238890
51negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.33925041
52sphingoid metabolic process (GO:0046519)3.33862932
53Arp2/3 complex-mediated actin nucleation (GO:0034314)3.32191520
54negative regulation of protein localization to cell surface (GO:2000009)3.30577307
55fibril organization (GO:0097435)3.26267312
56negative regulation of T cell apoptotic process (GO:0070233)3.26193472
57fusion of sperm to egg plasma membrane (GO:0007342)3.25409258
58negative regulation of execution phase of apoptosis (GO:1900118)3.25128887
59positive regulation of Rho protein signal transduction (GO:0035025)3.18097862
60positive regulation of granulocyte differentiation (GO:0030854)3.16014267
61positive regulation of cAMP-mediated signaling (GO:0043950)3.15891773
62positive regulation of systemic arterial blood pressure (GO:0003084)3.14383816
63positive regulation of receptor recycling (GO:0001921)3.13304398
64pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12453651
65eosinophil migration (GO:0072677)3.12208727
66positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.11702439
67cerebral cortex radially oriented cell migration (GO:0021799)3.09378320
68neutrophil activation (GO:0042119)3.09205479
69detection of other organism (GO:0098543)3.08766813
70negative regulation of neural precursor cell proliferation (GO:2000178)3.07160782
71diol metabolic process (GO:0034311)3.04840783
72regulation of receptor recycling (GO:0001919)3.04615210
73startle response (GO:0001964)3.03366471
74GPI anchor biosynthetic process (GO:0006506)3.01997507
75positive regulation of interleukin-1 beta secretion (GO:0050718)3.00651459
76L-amino acid import (GO:0043092)2.99577515
77detection of bacterium (GO:0016045)2.97954824
78phagocytosis, engulfment (GO:0006911)2.97429766
79low-density lipoprotein particle remodeling (GO:0034374)2.97302650
80negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.96115094
81nucleotide transmembrane transport (GO:1901679)2.95865903
82positive regulation of protein homodimerization activity (GO:0090073)2.95759115
83protein maturation by protein folding (GO:0022417)2.95010270
84RNA destabilization (GO:0050779)2.94570687
85developmental pigmentation (GO:0048066)2.93583485
86negative regulation of appetite (GO:0032099)2.92636839
87negative regulation of response to food (GO:0032096)2.92636839
88positive regulation of T cell cytokine production (GO:0002726)2.92541740
89fatty acid elongation (GO:0030497)2.91273400
90negative regulation of transcription by competitive promoter binding (GO:0010944)2.90688213
91negative regulation of T-helper cell differentiation (GO:0045623)2.89154154
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89154154
93regulation of lipoprotein metabolic process (GO:0050746)2.88987566
94positive regulation of blood coagulation (GO:0030194)2.88746158
95positive regulation of hemostasis (GO:1900048)2.88746158
96mitochondrial calcium ion homeostasis (GO:0051560)2.88115575
97regulation of megakaryocyte differentiation (GO:0045652)2.87744210
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.87481721
99negative regulation of exocytosis (GO:0045920)2.84692942
100endosome to melanosome transport (GO:0035646)2.83084894
101endosome to pigment granule transport (GO:0043485)2.83084894
102deoxyribonucleotide biosynthetic process (GO:0009263)2.82663231
103pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.82249690
104regulation of metalloenzyme activity (GO:0048552)2.81661016
105negative regulation of calcium ion transport into cytosol (GO:0010523)2.81016424
106negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.80394965
107sphingosine metabolic process (GO:0006670)2.80134339
108negative regulation of stress fiber assembly (GO:0051497)2.79783372
109negative regulation of mast cell activation (GO:0033004)2.79347074
110response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.77904441
111COPI coating of Golgi vesicle (GO:0048205)2.77521412
112Golgi transport vesicle coating (GO:0048200)2.77521412
113actin nucleation (GO:0045010)2.77292678
114positive regulation of mast cell activation (GO:0033005)2.76744995
115neutrophil activation involved in immune response (GO:0002283)2.76672062
116detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76556826
117limb bud formation (GO:0060174)2.75946687
118response to muramyl dipeptide (GO:0032495)2.75706062
119membrane invagination (GO:0010324)2.75428800
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75100141
121cellular response to ATP (GO:0071318)2.75096974
122retina layer formation (GO:0010842)2.74404420
123GPI anchor metabolic process (GO:0006505)2.73797321
124oligosaccharide catabolic process (GO:0009313)2.73269048
125regulation of inositol phosphate biosynthetic process (GO:0010919)2.73032121
126purinergic receptor signaling pathway (GO:0035587)2.71674238
127positive regulation of interleukin-1 secretion (GO:0050716)2.71352262
128response to redox state (GO:0051775)2.70246162
129central nervous system myelination (GO:0022010)2.69934752
130axon ensheathment in central nervous system (GO:0032291)2.69934752
131regulation of activation of Janus kinase activity (GO:0010533)2.69135896
132negative regulation of myoblast differentiation (GO:0045662)2.68310307
133positive regulation of cellular amide metabolic process (GO:0034250)2.68073482
134negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.68050420
135leukocyte tethering or rolling (GO:0050901)2.67979323
136preassembly of GPI anchor in ER membrane (GO:0016254)2.67549888
137regulation of macrophage derived foam cell differentiation (GO:0010743)2.67097207
138purine-containing compound salvage (GO:0043101)2.66799486
139negative regulation of heart contraction (GO:0045822)2.66200944
140autophagic vacuole fusion (GO:0000046)2.65589544
141interferon-gamma production (GO:0032609)2.64894890
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63492543
143negative regulation of focal adhesion assembly (GO:0051895)2.62382177
144negative regulation of cell junction assembly (GO:1901889)2.62382177
145negative regulation of adherens junction organization (GO:1903392)2.62382177
146mesenchymal cell differentiation involved in kidney development (GO:0072161)2.61567212
147mesenchymal cell differentiation involved in renal system development (GO:2001012)2.61567212
148reflex (GO:0060004)2.58944900
149ceramide catabolic process (GO:0046514)2.58282606
150positive regulation of coagulation (GO:0050820)2.55511979
151organelle membrane fusion (GO:0090174)2.55036373
152cyclic nucleotide catabolic process (GO:0009214)2.53875757
153cellular response to gamma radiation (GO:0071480)2.50868038
154positive regulation of T-helper 1 type immune response (GO:0002827)2.48547019
155regulation of interleukin-1 beta secretion (GO:0050706)2.48458055
156G-protein coupled receptor internalization (GO:0002031)2.47998075
157superoxide metabolic process (GO:0006801)2.47930301
158amino acid import (GO:0043090)2.47559392
159neuron cell-cell adhesion (GO:0007158)2.47316647
160response to peptidoglycan (GO:0032494)2.45976876
161nonmotile primary cilium assembly (GO:0035058)2.45814316
162DNA integration (GO:0015074)2.44803335
163regulation of platelet aggregation (GO:0090330)2.43462235
164activated T cell proliferation (GO:0050798)2.43217323
165T cell migration (GO:0072678)2.40010794
166monocyte chemotaxis (GO:0002548)2.38431367
167cornea development in camera-type eye (GO:0061303)2.38386551
168negative regulation of neurotransmitter secretion (GO:0046929)2.36853999
169positive regulation of heat generation (GO:0031652)2.35646888
170DNA deamination (GO:0045006)2.35436378
171amyloid precursor protein catabolic process (GO:0042987)2.34914064
172adenosine metabolic process (GO:0046085)2.33674227
173glycolipid biosynthetic process (GO:0009247)2.32766547
174glycolipid catabolic process (GO:0019377)2.31670177
175facial nerve structural organization (GO:0021612)2.31657715
176regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.30737266
177positive regulation of interleukin-1 beta production (GO:0032731)2.30589827
178lymphoid progenitor cell differentiation (GO:0002320)2.30424484
179spinal cord motor neuron differentiation (GO:0021522)2.29975599
180long-chain fatty acid biosynthetic process (GO:0042759)2.29867670
181import into cell (GO:0098657)2.29718593
182glucosamine-containing compound catabolic process (GO:1901072)2.29603917
183cAMP catabolic process (GO:0006198)2.28220585
184telomere maintenance via telomerase (GO:0007004)2.26978658
185dendritic cell migration (GO:0036336)2.26708558
186granulocyte activation (GO:0036230)2.25766006
187mannosylation (GO:0097502)2.24978090
188C-terminal protein lipidation (GO:0006501)2.24277684
189poly(A)+ mRNA export from nucleus (GO:0016973)2.23940462
190phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.23810183
191polyol transport (GO:0015791)2.22771616
192regulation of B cell receptor signaling pathway (GO:0050855)2.22485730
193regulation of fever generation (GO:0031620)2.22356687
194energy homeostasis (GO:0097009)2.22179805
195positive regulation of antigen processing and presentation (GO:0002579)2.22120664
196C-terminal protein amino acid modification (GO:0018410)2.19725392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* GBX2_23144817_ChIP-Seq_PC3_Human3.62437969
2SCL_19346495_ChIP-Seq_HPC-7_Human3.48628149
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.41658530
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25982697
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18209417
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.07787622
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95253713
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61040349
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60428886
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60320033
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53926700
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52372001
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.50860483
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50064339
15IGF1R_20145208_ChIP-Seq_DFB_Human2.46123494
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39163254
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37202673
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.34180106
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32263281
20E2F7_22180533_ChIP-Seq_HELA_Human2.32143662
21EZH2_22144423_ChIP-Seq_EOC_Human2.28939503
22HOXB4_20404135_ChIP-ChIP_EML_Mouse2.22937526
23GATA1_19941826_ChIP-Seq_K562_Human2.14958954
24SUZ12_27294783_Chip-Seq_NPCs_Mouse2.14503031
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12693923
26* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.12285150
27PCGF2_27294783_Chip-Seq_NPCs_Mouse2.11550608
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11099602
29GATA1_22383799_ChIP-Seq_G1ME_Mouse2.08420537
30GATA2_21666600_ChIP-Seq_HMVEC_Human2.07130717
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.07109381
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05415777
33TAF15_26573619_Chip-Seq_HEK293_Human2.04351611
34NFE2_27457419_Chip-Seq_LIVER_Mouse2.00382416
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.00360732
36P300_19829295_ChIP-Seq_ESCs_Human1.99118781
37* NANOG_18555785_Chip-Seq_ESCs_Mouse1.97207070
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96709187
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96514072
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.95593677
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94226372
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.92034746
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91456075
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91378851
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.91319237
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.90186273
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.89394224
48SUZ12_18555785_Chip-Seq_ESCs_Mouse1.89209545
49P53_22387025_ChIP-Seq_ESCs_Mouse1.86696204
50RNF2_27304074_Chip-Seq_NSC_Mouse1.80907098
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.79764390
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.77973592
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77288104
54EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77223741
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77181504
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76933472
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.76507570
58GATA2_19941826_ChIP-Seq_K562_Human1.75887461
59NMYC_18555785_Chip-Seq_ESCs_Mouse1.75061228
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.72303078
61* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70670410
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70312185
63* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69967640
64SPI1_23127762_ChIP-Seq_K562_Human1.69593541
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69115855
66ER_23166858_ChIP-Seq_MCF-7_Human1.68875463
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66888719
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.66529443
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65917804
70RUNX1_27457419_Chip-Seq_LIVER_Mouse1.65075775
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65009603
72VDR_22108803_ChIP-Seq_LS180_Human1.64854980
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.64843971
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62798061
75P300_18555785_Chip-Seq_ESCs_Mouse1.62247214
76* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62143854
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.61617487
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61452152
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.61285623
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60788718
81* SRF_21415370_ChIP-Seq_HL-1_Mouse1.60605671
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60394434
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.59404092
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59317173
85* ELK1_19687146_ChIP-ChIP_HELA_Human1.57848248
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.57140542
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56726936
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56387545
89* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55700555
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55648815
91* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54528380
92PU1_27457419_Chip-Seq_LIVER_Mouse1.53939434
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.53511451
94ZFX_18555785_Chip-Seq_ESCs_Mouse1.52589713
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52540583
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.52525086
97* SPI1_23547873_ChIP-Seq_NB4_Human1.51328387
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.50952383
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50091366
100SMAD4_21799915_ChIP-Seq_A2780_Human1.47875610
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.46468577
102SALL4_22934838_ChIP-ChIP_CD34+_Human1.45977203
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.45674570
104CTCF_18555785_Chip-Seq_ESCs_Mouse1.45612378
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.45358910
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45103376
107HTT_18923047_ChIP-ChIP_STHdh_Human1.43574113
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43534742
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41028765
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40497140
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39964443
112VDR_23849224_ChIP-Seq_CD4+_Human1.39786859
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38487377
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37645335
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.37636299
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36316825
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35078092
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34401195
119FUS_26573619_Chip-Seq_HEK293_Human1.34295523
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34171118
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33303766
122ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33026235
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.32804743
124ELK4_26923725_Chip-Seq_MESODERM_Mouse1.32802365
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.32556563
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30789520
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.30312059
128MYB_26560356_Chip-Seq_TH2_Human1.29630727
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28501599
130TFEB_21752829_ChIP-Seq_HELA_Human1.27969004
131EWS_26573619_Chip-Seq_HEK293_Human1.27893045
132FOXP3_21729870_ChIP-Seq_TREG_Human1.27626698
133DCP1A_22483619_ChIP-Seq_HELA_Human1.27293377
134IRF8_21731497_ChIP-ChIP_J774_Mouse1.25352816
135* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25195440
136E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25138257
137* KDM2B_26808549_Chip-Seq_REH_Human1.25125134
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24651082
139IRF8_27001747_Chip-Seq_BMDM_Mouse1.23980388
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23900338
141BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23206977
142* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22020690
143CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.21429686
144AR_21572438_ChIP-Seq_LNCaP_Human1.20838463
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20182415
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20071684
147* STAT3_23295773_ChIP-Seq_U87_Human1.20069331
148IRF1_19129219_ChIP-ChIP_H3396_Human1.19818580
149ETS1_22383799_ChIP-Seq_G1ME_Mouse1.19095076
150TP53_18474530_ChIP-ChIP_U2OS_Human1.18691484
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18501120
152* TCF4_23295773_ChIP-Seq_U87_Human1.18073083
153* AR_25329375_ChIP-Seq_VCAP_Human1.17961463
154JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17832340
155LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15948859
156RNF2_27304074_Chip-Seq_ESCs_Mouse1.15937022
157CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15772943
158LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13508795
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12912697
160PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12536184
161CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11555813
162EZH2_27294783_Chip-Seq_ESCs_Mouse1.10318657
163RUNX2_22187159_ChIP-Seq_PCA_Human1.09371452
164* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09138630
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08676555
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08676555
167MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07137569
168EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06989369
169RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06989369
170GATA1_22025678_ChIP-Seq_K562_Human1.06687213
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04921371
172FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04363751
173SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04266756
174NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02532086
175PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02159591
176JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01727964
177HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00250480
178GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99728111
179MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99525141
180RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99082184
181RUNX_20019798_ChIP-Seq_JUKART_Human0.98307632
182PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98205810
183UTX_26944678_Chip-Seq_JUKART_Human0.97938966
184WT1_19549856_ChIP-ChIP_CCG9911_Human0.95858834
185TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94924082
186* ETS1_20019798_ChIP-Seq_JURKAT_Human0.94311671
187* BRD4_25478319_ChIP-Seq_HGPS_Human0.94091533
188JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92909296
189NCOR1_26117541_ChIP-Seq_K562_Human0.91602463
190GATA3_27048872_Chip-Seq_THYMUS_Human0.90189883
191GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88881505
192MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88863380
193MYB_26560356_Chip-Seq_TH1_Human0.88671857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.60980254
2MP0001188_hyperpigmentation4.02038050
3MP0008004_abnormal_stomach_pH3.66430888
4MP0000566_synostosis3.07990784
5MP0000465_gastrointestinal_hemorrhage3.06273590
6MP0003566_abnormal_cell_adhesion2.83062592
7MP0002102_abnormal_ear_morphology2.77903376
8MP0006292_abnormal_olfactory_placode2.76472747
9MP0008260_abnormal_autophagy2.62665466
10MP0001986_abnormal_taste_sensitivity2.48278688
11MP0003136_yellow_coat_color2.47840045
12MP0000015_abnormal_ear_pigmentation2.47295480
13MP0005171_absent_coat_pigmentation2.46485301
14MP0008438_abnormal_cutaneous_collagen2.44333324
15MP0002638_abnormal_pupillary_reflex2.41343333
16MP0004147_increased_porphyrin_level2.35402319
17MP0005646_abnormal_pituitary_gland2.31962274
18MP0002277_abnormal_respiratory_mucosa2.31714957
19MP0010386_abnormal_urinary_bladder2.29836845
20MP0005645_abnormal_hypothalamus_physiol2.29632010
21MP0004381_abnormal_hair_follicle2.26825748
22MP0004742_abnormal_vestibular_system2.20793352
23MP0003880_abnormal_central_pattern2.17302555
24MP0005409_darkened_coat_color2.13173403
25MP0003183_abnormal_peptide_metabolism2.02844190
26MP0004084_abnormal_cardiac_muscle2.01562319
27MP0009697_abnormal_copulation1.94737825
28MP0000343_altered_response_to1.93474606
29MP0002877_abnormal_melanocyte_morpholog1.90509793
30MP0002876_abnormal_thyroid_physiology1.84212222
31MP0001661_extended_life_span1.80298067
32MP0005075_abnormal_melanosome_morpholog1.76945211
33MP0003828_pulmonary_edema1.73103647
34MP0001486_abnormal_startle_reflex1.72043992
35MP0005174_abnormal_tail_pigmentation1.70151739
36MP0004036_abnormal_muscle_relaxation1.60877897
37MP0005671_abnormal_response_to1.60837187
38MP0009780_abnormal_chondrocyte_physiolo1.60489692
39MP0005410_abnormal_fertilization1.60108261
40MP0001879_abnormal_lymphatic_vessel1.59232052
41MP0004510_myositis1.59135599
42MP0002735_abnormal_chemical_nociception1.58651941
43MP0005058_abnormal_lysosome_morphology1.58124208
44MP0003724_increased_susceptibility_to1.56479842
45MP0000230_abnormal_systemic_arterial1.54698237
46MP0005379_endocrine/exocrine_gland_phen1.53179658
47MP0002398_abnormal_bone_marrow1.52186946
48MP0006082_CNS_inflammation1.51577601
49MP0005451_abnormal_body_composition1.51150561
50MP0006054_spinal_hemorrhage1.46265686
51MP0002148_abnormal_hypersensitivity_rea1.42944267
52MP0004134_abnormal_chest_morphology1.42878108
53MP0001851_eye_inflammation1.42445497
54MP0001502_abnormal_circadian_rhythm1.41804376
55MP0003172_abnormal_lysosome_physiology1.41670067
56MP0001873_stomach_inflammation1.40995763
57MP0002009_preneoplasia1.40108516
58MP0003806_abnormal_nucleotide_metabolis1.35770808
59MP0008775_abnormal_heart_ventricle1.35507631
60MP0003718_maternal_effect1.35489054
61MP0004142_abnormal_muscle_tone1.34377777
62MP0008007_abnormal_cellular_replicative1.33249373
63MP0005310_abnormal_salivary_gland1.33215776
64MP0005083_abnormal_biliary_tract1.32258057
65MP0005023_abnormal_wound_healing1.31206307
66MP0002419_abnormal_innate_immunity1.30140287
67MP0000358_abnormal_cell_content/1.28403133
68MP0000026_abnormal_inner_ear1.28356396
69MP0001835_abnormal_antigen_presentation1.28132562
70MP0005397_hematopoietic_system_phenotyp1.26188345
71MP0001545_abnormal_hematopoietic_system1.26188345
72MP0003950_abnormal_plasma_membrane1.24263308
73MP0009763_increased_sensitivity_to1.24260336
74MP0005408_hypopigmentation1.24130688
75MP0006036_abnormal_mitochondrial_physio1.23462439
76MP0002693_abnormal_pancreas_physiology1.22748474
77MP0001958_emphysema1.21797141
78MP0002938_white_spotting1.21713445
79MP0003763_abnormal_thymus_physiology1.21516737
80MP0010155_abnormal_intestine_physiology1.20006560
81MP0004947_skin_inflammation1.19636910
82MP0003656_abnormal_erythrocyte_physiolo1.16941660
83MP0000689_abnormal_spleen_morphology1.16179312
84MP0005275_abnormal_skin_tensile1.14548269
85MP0005165_increased_susceptibility_to1.12480125
86MP0004272_abnormal_basement_membrane1.12462943
87MP0010352_gastrointestinal_tract_polyps1.12253501
88MP0005670_abnormal_white_adipose1.11820271
89MP0000920_abnormal_myelination1.11124168
90MP0005000_abnormal_immune_tolerance1.10746707
91MP0002429_abnormal_blood_cell1.10057946
92MP0001790_abnormal_immune_system1.09375466
93MP0005387_immune_system_phenotype1.09375466
94MP0002095_abnormal_skin_pigmentation1.09078450
95MP0001533_abnormal_skeleton_physiology1.08268768
96MP0008932_abnormal_embryonic_tissue1.07811834
97MP0005623_abnormal_meninges_morphology1.07218478
98MP0005501_abnormal_skin_physiology1.06668518
99MP0004808_abnormal_hematopoietic_stem1.06193209
100MP0006276_abnormal_autonomic_nervous1.05972341
101MP0002723_abnormal_immune_serum1.05937252
102MP0002722_abnormal_immune_system1.05750119
103MP0000372_irregular_coat_pigmentation1.05642627
104MP0000249_abnormal_blood_vessel1.03392036
105MP0003638_abnormal_response/metabolism_1.03202502
106MP0002132_abnormal_respiratory_system1.02770460
107MP0003300_gastrointestinal_ulcer1.02502582
108MP0002736_abnormal_nociception_after1.01762376
109MP0003186_abnormal_redox_activity1.01417886
110MP0001963_abnormal_hearing_physiology1.01341344
111MP0001186_pigmentation_phenotype1.00535680
112MP0009384_cardiac_valve_regurgitation0.99634643
113MP0003111_abnormal_nucleus_morphology0.99521420
114MP0008058_abnormal_DNA_repair0.99410936
115MP0003787_abnormal_imprinting0.98639688
116MP0005423_abnormal_somatic_nervous0.98173957
117MP0002138_abnormal_hepatobiliary_system0.97821407
118MP0002272_abnormal_nervous_system0.96414709
119MP0000858_altered_metastatic_potential0.96317535
120MP0002067_abnormal_sensory_capabilities0.96174179
121MP0009765_abnormal_xenobiotic_induced0.94838235
122MP0002163_abnormal_gland_morphology0.94431347
123MP0009785_altered_susceptibility_to0.94060554
124MP0000685_abnormal_immune_system0.93752558
125MP0004782_abnormal_surfactant_physiolog0.93338943
126MP0003866_abnormal_defecation0.92776145
127MP0002452_abnormal_antigen_presenting0.92551368
128MP0010094_abnormal_chromosome_stability0.91332830
129MP0003938_abnormal_ear_development0.90521067
130MP0001485_abnormal_pinna_reflex0.90081578
131MP0006035_abnormal_mitochondrial_morpho0.88463849
132MP0005025_abnormal_response_to0.87729455
133MP0001905_abnormal_dopamine_level0.87507952
134MP0001968_abnormal_touch/_nociception0.87253522
135MP0002998_abnormal_bone_remodeling0.87215484
136MP0004957_abnormal_blastocyst_morpholog0.87095168
137MP0000703_abnormal_thymus_morphology0.87019183
138MP0000383_abnormal_hair_follicle0.86431874
139MP0003091_abnormal_cell_migration0.85858491
140MP0002019_abnormal_tumor_incidence0.85586858
141MP0001529_abnormal_vocalization0.85504156
142MP0005621_abnormal_cell_physiology0.84858496
143MP0005257_abnormal_intraocular_pressure0.84632322
144MP0003436_decreased_susceptibility_to0.84361624
145MP0002420_abnormal_adaptive_immunity0.84339112
146MP0001984_abnormal_olfaction0.83866962
147MP0009046_muscle_twitch0.83406883
148MP0002734_abnormal_mechanical_nocicepti0.83272547
149MP0000778_abnormal_nervous_system0.82921504
150MP0000716_abnormal_immune_system0.82591920
151MP0001542_abnormal_bone_strength0.82288719
152MP0001819_abnormal_immune_cell0.82282187
153MP0000681_abnormal_thyroid_gland0.82214530
154MP0009745_abnormal_behavioral_response0.82038133
155MP0002177_abnormal_outer_ear0.81858664
156MP0005084_abnormal_gallbladder_morpholo0.81820299
157MP0008872_abnormal_physiological_respon0.80581337
158MP0001764_abnormal_homeostasis0.79905127
159MP0002128_abnormal_blood_circulation0.79558359
160MP0001845_abnormal_inflammatory_respons0.79443927
161MP0001663_abnormal_digestive_system0.79365626
162MP0004270_analgesia0.78996190
163MP0002572_abnormal_emotion/affect_behav0.78688644
164MP0002184_abnormal_innervation0.77998014
165MP0003045_fibrosis0.77708746
166MP0005384_cellular_phenotype0.77020679
167MP0003279_aneurysm0.76361139
168MP0000631_abnormal_neuroendocrine_gland0.75861263
169MP0002557_abnormal_social/conspecific_i0.75681605
170MP0000490_abnormal_crypts_of0.75559585
171MP0009333_abnormal_splenocyte_physiolog0.75335724
172MP0002332_abnormal_exercise_endurance0.75316172
173MP0009764_decreased_sensitivity_to0.73858724
174MP0001800_abnormal_humoral_immune0.72082021
175MP0003195_calcinosis0.72034300
176MP0002396_abnormal_hematopoietic_system0.72008280
177MP0008995_early_reproductive_senescence0.71255136
178MP0010368_abnormal_lymphatic_system0.70803250
179MP0001970_abnormal_pain_threshold0.69588540

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.58293659
2Increased mean platelet volume (HP:0011877)9.12615105
3Menorrhagia (HP:0000132)8.66607169
4Abnormal platelet volume (HP:0011876)8.55941390
5Petechiae (HP:0000967)8.52443808
6Purpura (HP:0000979)6.87744458
7Epistaxis (HP:0000421)6.37484713
8Abnormal platelet function (HP:0011869)5.33840301
9Impaired platelet aggregation (HP:0003540)5.33840301
10Gingival bleeding (HP:0000225)5.27578514
11Hyperlipoproteinemia (HP:0010980)4.74965831
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42973966
13Chromsome breakage (HP:0040012)4.12741741
14Abnormal pupillary function (HP:0007686)3.63101778
15Upper limb muscle weakness (HP:0003484)3.61706323
16White forelock (HP:0002211)3.59695504
17Patchy hypopigmentation of hair (HP:0011365)3.45998638
18Spontaneous hematomas (HP:0007420)3.43801094
19Septo-optic dysplasia (HP:0100842)3.40553355
20Dyschromatopsia (HP:0007641)3.34179263
21Prostate neoplasm (HP:0100787)3.27649973
22Paralysis (HP:0003470)3.26754899
23Abnormality of the columella (HP:0009929)3.18744918
24Poikilocytosis (HP:0004447)3.06057802
25Bruising susceptibility (HP:0000978)3.05183742
26Congenital sensorineural hearing impairment (HP:0008527)3.00583654
27Duplicated collecting system (HP:0000081)2.99557598
28Conjunctival telangiectasia (HP:0000524)2.99346526
29Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.97394911
30Recurrent abscess formation (HP:0002722)2.96438323
31Tubulointerstitial nephritis (HP:0001970)2.88569056
32Hypothermia (HP:0002045)2.87939121
33Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.80966358
34Abnormality of the common coagulation pathway (HP:0010990)2.76527908
35Abnormality of the renal collecting system (HP:0004742)2.76032681
36Acanthocytosis (HP:0001927)2.74597934
37Prolonged neonatal jaundice (HP:0006579)2.73691616
38Optic nerve hypoplasia (HP:0000609)2.72892963
39Parakeratosis (HP:0001036)2.69002091
40Febrile seizures (HP:0002373)2.67840838
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.61918092
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.55267538
43Absent/shortened dynein arms (HP:0200106)2.55267538
44Recurrent bacterial skin infections (HP:0005406)2.54182033
45Vacuolated lymphocytes (HP:0001922)2.52561735
46Type I transferrin isoform profile (HP:0003642)2.48925774
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.48382878
48Increased IgM level (HP:0003496)2.46619308
49Abnormal auditory evoked potentials (HP:0006958)2.45963390
50Abnormality of lateral ventricle (HP:0030047)2.44356176
51Increased density of long bones (HP:0006392)2.41102992
52Generalized aminoaciduria (HP:0002909)2.38711629
53Retinal dysplasia (HP:0007973)2.37572365
54Reduced antithrombin III activity (HP:0001976)2.33502357
55Renal cortical cysts (HP:0000803)2.30817230
56Abnormality of the frontal sinuses (HP:0002687)2.30162692
57Aplasia cutis congenita (HP:0001057)2.29425297
58Tinnitus (HP:0000360)2.28576530
59Median cleft lip (HP:0000161)2.27924936
60Abnormality of DNA repair (HP:0003254)2.27806522
61Aplastic anemia (HP:0001915)2.25997736
62Retrobulbar optic neuritis (HP:0100654)2.25770404
63Optic neuritis (HP:0100653)2.25770404
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22706003
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22706003
66Anomalous pulmonary venous return (HP:0010772)2.22582293
67Distal lower limb amyotrophy (HP:0008944)2.22041269
68Recurrent cutaneous fungal infections (HP:0011370)2.21982144
69Chronic mucocutaneous candidiasis (HP:0002728)2.21982144
70Abnormality of the septum pellucidum (HP:0007375)2.21212175
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20462880
72Protruding tongue (HP:0010808)2.20456801
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20368711
74Hypoplasia of the fovea (HP:0007750)2.17515109
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.17515109
76Follicular hyperkeratosis (HP:0007502)2.16447646
77Decreased central vision (HP:0007663)2.16280404
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14622684
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12460823
80Abnormal protein N-linked glycosylation (HP:0012347)2.12460823
81Abnormal protein glycosylation (HP:0012346)2.12460823
82Abnormal glycosylation (HP:0012345)2.12460823
83Absent septum pellucidum (HP:0001331)2.11988926
84Abnormal ciliary motility (HP:0012262)2.10722255
85Symptomatic seizures (HP:0011145)2.10024465
86Stomatitis (HP:0010280)2.09003832
87Aortic aneurysm (HP:0004942)2.04928412
88Recurrent skin infections (HP:0001581)2.02320982
89Joint swelling (HP:0001386)2.01744618
90IgA deficiency (HP:0002720)1.97464534
91Neoplasm of the rectum (HP:0100743)1.96887129
92Orthostatic hypotension (HP:0001278)1.96098296
93Obstructive lung disease (HP:0006536)1.93319444
94Chronic obstructive pulmonary disease (HP:0006510)1.93319444
95Abnormality of alanine metabolism (HP:0010916)1.92643656
96Hyperalaninemia (HP:0003348)1.92643656
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92643656
98Hyperventilation (HP:0002883)1.92281409
99Male infertility (HP:0003251)1.91961757
100Hepatosplenomegaly (HP:0001433)1.91330294
101Conjugated hyperbilirubinemia (HP:0002908)1.91292471
102Xanthomatosis (HP:0000991)1.90004516
103Mitral stenosis (HP:0001718)1.88903570
104Focal motor seizures (HP:0011153)1.88335310
105Abnormality of the prostate (HP:0008775)1.86743658
106Autoimmune hemolytic anemia (HP:0001890)1.86440311
107Abnormal hair whorl (HP:0010721)1.84869828
108Abnormality of the pulmonary veins (HP:0011718)1.84715377
109Abnormality of skeletal muscle fiber size (HP:0012084)1.84118990
110Joint hemorrhage (HP:0005261)1.83630575
111Submucous cleft hard palate (HP:0000176)1.83175893
112Nausea (HP:0002018)1.83082961
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82973949
114Abnormality of the axillary hair (HP:0100134)1.79484382
115Abnormality of secondary sexual hair (HP:0009888)1.79484382
116Hypomagnesemia (HP:0002917)1.79301607
117Abnormality of iron homeostasis (HP:0011031)1.79296234
118Abnormality of calcium-phosphate metabolism (HP:0100530)1.78921954
119Abnormality of the Achilles tendon (HP:0005109)1.77084249
120Fatigue (HP:0012378)1.77039417
121Papillary thyroid carcinoma (HP:0002895)1.75045281
122Methylmalonic acidemia (HP:0002912)1.74728401
123Nemaline bodies (HP:0003798)1.74345118
124Failure to thrive in infancy (HP:0001531)1.73356583
125Anhidrosis (HP:0000970)1.73308606
126Tongue fasciculations (HP:0001308)1.72921292
127Abnormal spermatogenesis (HP:0008669)1.72360003
128Hypoglycemic seizures (HP:0002173)1.71909850
129Chronic diarrhea (HP:0002028)1.71520077
130Recurrent pneumonia (HP:0006532)1.71358379
131Spinal rigidity (HP:0003306)1.71120586
132Abnormality of the preputium (HP:0100587)1.71076636
133Broad nasal tip (HP:0000455)1.69842239
134Lower limb amyotrophy (HP:0007210)1.69743557
135Cheilitis (HP:0100825)1.69465617
136Muscle fiber atrophy (HP:0100295)1.68575664
137Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.68482062
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.68118336
139IgG deficiency (HP:0004315)1.67440919
140Abnormal gallbladder physiology (HP:0012438)1.67070205
141Cholecystitis (HP:0001082)1.67070205
142Myocardial infarction (HP:0001658)1.67005783
143Ileus (HP:0002595)1.66990234
144Premature rupture of membranes (HP:0001788)1.66708913
145J-shaped sella turcica (HP:0002680)1.65843452
146Acute hepatic failure (HP:0006554)1.65636784
147Adrenal hypoplasia (HP:0000835)1.65503825
148Insidious onset (HP:0003587)1.65240462
149Termporal pattern (HP:0011008)1.65240462
150Premature loss of primary teeth (HP:0006323)1.65042422
151Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64414764
152Encephalitis (HP:0002383)1.64263459
153Mucosal telangiectasiae (HP:0100579)1.63628083
154Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.63623457
155Absent speech (HP:0001344)1.63579096
156Eczematoid dermatitis (HP:0000976)1.61596819
157Abnormal respiratory motile cilium morphology (HP:0005938)1.60925956
158Abnormal respiratory epithelium morphology (HP:0012253)1.60925956
159Abnormality of incisor morphology (HP:0011063)1.60334260
160Hypoproteinemia (HP:0003075)1.60292393
161Enlarged kidneys (HP:0000105)1.59672084
162Polycythemia (HP:0001901)1.59518490
163Cupped ear (HP:0000378)1.59413477
164Hyperphosphatemia (HP:0002905)1.59292433
165Eosinophilia (HP:0001880)1.59142510
166Osteomalacia (HP:0002749)1.58974401
167Prolonged partial thromboplastin time (HP:0003645)1.58424962
168Recurrent fungal infections (HP:0002841)1.58241023
169Basal ganglia calcification (HP:0002135)1.58151488
170Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.55900503
171Granulocytopenia (HP:0001913)1.55587298
1723-Methylglutaconic aciduria (HP:0003535)1.54848951
173Slender build (HP:0001533)1.54008517
174Insulin-resistant diabetes mellitus (HP:0000831)1.53146015
175Renal Fanconi syndrome (HP:0001994)1.52270787
176Tetraparesis (HP:0002273)1.51955162
177Type 2 muscle fiber atrophy (HP:0003554)1.51147114
178Increased variability in muscle fiber diameter (HP:0003557)1.48876956
179Ankle contracture (HP:0006466)1.48628642
180Abnormality of oral frenula (HP:0000190)1.47926207
181Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.47531343
182IgM deficiency (HP:0002850)1.47515103
183Erythema (HP:0010783)1.47344844
184Inflammation of the large intestine (HP:0002037)1.47095401
185Testicular neoplasm (HP:0010788)1.46466843
186Abnormality of transition element cation homeostasis (HP:0011030)1.45544013
187Muscle fibrillation (HP:0010546)1.42611992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.03619111
2MYLK3.81337146
3TNIK3.42224399
4EIF2AK13.37791016
5SCYL23.36871709
6INSRR3.26144870
7BMX2.93516065
8IRAK42.90937007
9STK162.59643062
10IRAK32.55886234
11TAOK32.52031993
12MAP3K142.16613877
13ILK2.15317844
14MKNK22.11480581
15TXK2.02990445
16BLK1.97812592
17PBK1.87476401
18PTK2B1.85014525
19TESK21.84532324
20BMPR21.84173482
21BCKDK1.79376793
22CSF1R1.79342791
23ZAP701.77371575
24MAP4K21.74164842
25TIE11.71930326
26EIF2AK21.71357942
27NEK91.68605739
28ZAK1.66093710
29MAP3K121.62374134
30AKT31.59910981
31NTRK31.59517408
32MUSK1.52127964
33RIPK41.50399083
34GRK61.49956360
35PIM21.47899959
36YES11.46440581
37JAK31.45584522
38BMPR1B1.42510304
39MAPKAPK31.41678551
40SIK31.40388990
41TLK11.37850394
42NEK61.36839674
43ADRBK21.36225317
44MAP2K71.35307706
45ACVR1B1.32360402
46PKN11.31691700
47MAP2K31.30941665
48TEC1.29906361
49GRK11.26642638
50MAPKAPK51.24838729
51DAPK31.23839906
52CCNB11.21981224
53IRAK11.21400992
54FLT31.19371861
55MAPK151.18814242
56GRK71.17340798
57MAP3K61.17178797
58PAK11.16404147
59TNK21.12281591
60OXSR11.10127945
61CDK31.09896619
62MKNK11.07521081
63HCK1.06760226
64TAOK21.02586678
65PLK21.02559065
66NME20.97762842
67VRK10.97245794
68PIK3CG0.95161051
69MAPK130.91624961
70PRPF4B0.89742846
71KIT0.89594219
72SRPK10.86959483
73MAP3K30.86165674
74FES0.84625115
75PAK20.80515338
76MAP3K130.79868185
77MAP4K10.79394907
78PIK3CA0.78327542
79TRIM280.78118151
80IRAK20.76884282
81MAP3K50.76794010
82STK30.72585696
83RAF10.72034628
84TESK10.68685678
85LMTK20.66836028
86CLK10.65318343
87SGK20.65225413
88NLK0.65168986
89MAPK110.64304135
90FGR0.62824992
91IKBKB0.62802882
92AURKA0.62504970
93CAMK2B0.61330542
94DAPK10.61130541
95NUAK10.60708652
96STK40.60412826
97TRPM70.60241893
98PLK30.59052378
99IKBKE0.58902862
100EIF2AK30.58683539
101MST40.57855570
102STK240.57689883
103MARK30.57518648
104EPHA40.56834842
105SGK2230.56225841
106SGK4940.56225841
107STK390.56173355
108LYN0.55896104
109STK38L0.54515094
110LCK0.54108812
111CDK80.53218985
112CAMK2A0.52459646
113PRKCE0.51510397
114CAMK2D0.51013026
115DYRK20.49601684
116ARAF0.49177187
117FRK0.48962744
118STK100.45271718
119PRKD10.45235117
120ITK0.44912696
121PRKCQ0.43956761
122JAK10.43446692
123MAP2K10.43376711
124BRAF0.42436801
125SYK0.41203715
126SGK10.40755813
127EPHA30.40246556
128WNK30.39891255
129NEK10.38951447
130PDGFRB0.38413016
131PIM10.38219386
132CDK90.37810235
133DYRK1A0.37375802
134LIMK10.36584650
135CDK190.36349535
136PRKG10.36317931
137BTK0.35352576
138MAPK120.34518307
139GRK50.33909600
140BCR0.33873580
141PDK20.33180558
142ADRBK10.32419079
143EPHB10.32375452
144BRD40.32305269
145CSK0.31075034
146PINK10.30275746
147MINK10.30096631
148CDK140.29840293
149HIPK20.29185576
150CHUK0.29107133
151IGF1R0.27908933
152PRKCD0.27856579
153KDR0.27673074
154PAK30.27671097
155RPS6KA50.27359035
156CAMK10.26964038
157ABL20.26651468
158TBK10.26294139
159TAF10.24819558

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.94020067
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.76752736
3Mismatch repair_Homo sapiens_hsa034303.14498561
4Protein export_Homo sapiens_hsa030602.74232567
5Systemic lupus erythematosus_Homo sapiens_hsa053222.39654595
6ECM-receptor interaction_Homo sapiens_hsa045122.37059952
7Sphingolipid metabolism_Homo sapiens_hsa006002.25730422
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23041677
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.22665484
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.15291119
11Other glycan degradation_Homo sapiens_hsa005112.13778677
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00398152
13Shigellosis_Homo sapiens_hsa051312.00352840
14Rheumatoid arthritis_Homo sapiens_hsa053231.93780852
15Graft-versus-host disease_Homo sapiens_hsa053321.92645771
16Alcoholism_Homo sapiens_hsa050341.91239769
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80909206
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76108632
19Proteasome_Homo sapiens_hsa030501.75736852
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73890712
21Allograft rejection_Homo sapiens_hsa053301.73060344
22DNA replication_Homo sapiens_hsa030301.72537011
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67280507
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67100087
25Nucleotide excision repair_Homo sapiens_hsa034201.67023737
26Nicotine addiction_Homo sapiens_hsa050331.66501060
27Autoimmune thyroid disease_Homo sapiens_hsa053201.64975752
28Fanconi anemia pathway_Homo sapiens_hsa034601.64393785
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.61003451
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60953153
31One carbon pool by folate_Homo sapiens_hsa006701.60243698
32Type I diabetes mellitus_Homo sapiens_hsa049401.56958214
33Ether lipid metabolism_Homo sapiens_hsa005651.47866234
34Non-homologous end-joining_Homo sapiens_hsa034501.47822635
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46972200
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.44672930
37Steroid biosynthesis_Homo sapiens_hsa001001.43395041
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39510510
39Phagosome_Homo sapiens_hsa041451.35204888
40Pyrimidine metabolism_Homo sapiens_hsa002401.32847560
41N-Glycan biosynthesis_Homo sapiens_hsa005101.32706454
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32635290
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31910229
44Morphine addiction_Homo sapiens_hsa050321.31385420
45Collecting duct acid secretion_Homo sapiens_hsa049661.31382925
46Viral carcinogenesis_Homo sapiens_hsa052031.29263903
47Gap junction_Homo sapiens_hsa045401.26090235
48Regulation of autophagy_Homo sapiens_hsa041401.25870614
49Arachidonic acid metabolism_Homo sapiens_hsa005901.25486625
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25468012
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22003051
52Base excision repair_Homo sapiens_hsa034101.21406873
53Vitamin digestion and absorption_Homo sapiens_hsa049771.18603119
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.18541101
55Pancreatic secretion_Homo sapiens_hsa049721.17910518
56Endocytosis_Homo sapiens_hsa041441.17566693
57Hematopoietic cell lineage_Homo sapiens_hsa046401.17517237
58Histidine metabolism_Homo sapiens_hsa003401.13842317
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12472645
60Nitrogen metabolism_Homo sapiens_hsa009101.11677435
61Serotonergic synapse_Homo sapiens_hsa047261.11290734
62Basal transcription factors_Homo sapiens_hsa030221.11036924
63Linoleic acid metabolism_Homo sapiens_hsa005911.10857612
64Focal adhesion_Homo sapiens_hsa045101.10251754
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06121774
66Pentose phosphate pathway_Homo sapiens_hsa000301.04100604
67B cell receptor signaling pathway_Homo sapiens_hsa046621.04071816
68Insulin secretion_Homo sapiens_hsa049111.03140290
69Taste transduction_Homo sapiens_hsa047421.01829293
70Measles_Homo sapiens_hsa051621.00762947
71Glycerolipid metabolism_Homo sapiens_hsa005611.00429229
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99564339
73Glutathione metabolism_Homo sapiens_hsa004800.99552548
74Glutamatergic synapse_Homo sapiens_hsa047240.93824371
75Asthma_Homo sapiens_hsa053100.93065147
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92811441
77Circadian rhythm_Homo sapiens_hsa047100.90780504
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89888143
79Vibrio cholerae infection_Homo sapiens_hsa051100.88064830
80Sulfur relay system_Homo sapiens_hsa041220.85657049
81Leishmaniasis_Homo sapiens_hsa051400.85641477
82Small cell lung cancer_Homo sapiens_hsa052220.84880549
83Primary immunodeficiency_Homo sapiens_hsa053400.80977321
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80572571
85Lysosome_Homo sapiens_hsa041420.80086223
86Pancreatic cancer_Homo sapiens_hsa052120.79650198
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77864938
88Homologous recombination_Homo sapiens_hsa034400.77407409
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75863291
90Ovarian steroidogenesis_Homo sapiens_hsa049130.75328766
91Chemokine signaling pathway_Homo sapiens_hsa040620.75061753
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74917738
93African trypanosomiasis_Homo sapiens_hsa051430.74617918
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74613083
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.74235959
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72910169
97Oxidative phosphorylation_Homo sapiens_hsa001900.72437012
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72161492
99ABC transporters_Homo sapiens_hsa020100.71711206
100Fatty acid elongation_Homo sapiens_hsa000620.71094616
101RNA polymerase_Homo sapiens_hsa030200.69349012
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.69124886
103Osteoclast differentiation_Homo sapiens_hsa043800.68964806
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68116333
105Arginine and proline metabolism_Homo sapiens_hsa003300.66882160
106T cell receptor signaling pathway_Homo sapiens_hsa046600.66806943
107Tuberculosis_Homo sapiens_hsa051520.66191607
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65694948
109Malaria_Homo sapiens_hsa051440.65313150
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64927327
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.64821154
112Apoptosis_Homo sapiens_hsa042100.63630445
113Circadian entrainment_Homo sapiens_hsa047130.62031339
114Purine metabolism_Homo sapiens_hsa002300.61295836
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.61008175
116Calcium signaling pathway_Homo sapiens_hsa040200.60939981
117Renin-angiotensin system_Homo sapiens_hsa046140.60568689
118Inositol phosphate metabolism_Homo sapiens_hsa005620.60164853
119TNF signaling pathway_Homo sapiens_hsa046680.57918939
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57389906
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55669214
122Phototransduction_Homo sapiens_hsa047440.54288608
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53783258
124Viral myocarditis_Homo sapiens_hsa054160.53226713
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52155798
126Cell cycle_Homo sapiens_hsa041100.51689258
127Salmonella infection_Homo sapiens_hsa051320.50803344
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50084924
129RNA transport_Homo sapiens_hsa030130.49698628
130Sulfur metabolism_Homo sapiens_hsa009200.49477063
131Axon guidance_Homo sapiens_hsa043600.49010031
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.48335687
133Ras signaling pathway_Homo sapiens_hsa040140.47393150
134Cocaine addiction_Homo sapiens_hsa050300.47371440
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46972091
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45002249
137GABAergic synapse_Homo sapiens_hsa047270.44996997
138Alzheimers disease_Homo sapiens_hsa050100.44470027
139Olfactory transduction_Homo sapiens_hsa047400.44101427
140Salivary secretion_Homo sapiens_hsa049700.44063108
141Vitamin B6 metabolism_Homo sapiens_hsa007500.43393160
142Melanoma_Homo sapiens_hsa052180.43029754
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43024597
144Type II diabetes mellitus_Homo sapiens_hsa049300.42942669
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.41534740
146Dilated cardiomyopathy_Homo sapiens_hsa054140.41348489
147Synaptic vesicle cycle_Homo sapiens_hsa047210.40720595
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40683842
149cAMP signaling pathway_Homo sapiens_hsa040240.40093978
150RNA degradation_Homo sapiens_hsa030180.39346624
151Legionellosis_Homo sapiens_hsa051340.39074792
152beta-Alanine metabolism_Homo sapiens_hsa004100.38320409
153Oocyte meiosis_Homo sapiens_hsa041140.38264452
154Antigen processing and presentation_Homo sapiens_hsa046120.36162667
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35816300
156Long-term depression_Homo sapiens_hsa047300.33015661
157p53 signaling pathway_Homo sapiens_hsa041150.32537447
158Non-small cell lung cancer_Homo sapiens_hsa052230.30957525
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29052821
160Glioma_Homo sapiens_hsa052140.27384150
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24899266
162Biosynthesis of amino acids_Homo sapiens_hsa012300.24843174
163Hepatitis B_Homo sapiens_hsa051610.24712417
164PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24272455

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