SCG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.92503619
2COPI coating of Golgi vesicle (GO:0048205)7.92503619
3protein maturation by protein folding (GO:0022417)5.61656234
4peptide hormone processing (GO:0016486)5.50516623
5endocrine pancreas development (GO:0031018)5.22939690
6insulin secretion (GO:0030073)4.97354330
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.92818629
8detection of calcium ion (GO:0005513)4.68460583
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.64691172
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.61411034
11COPII vesicle coating (GO:0048208)4.48063360
12glycerophospholipid catabolic process (GO:0046475)4.43763682
13ER overload response (GO:0006983)4.34306777
14regulation of type B pancreatic cell apoptotic process (GO:2000674)4.32797719
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.26259028
16regulation of insulin secretion (GO:0050796)4.16944336
17positive regulation of insulin secretion (GO:0032024)4.15191168
18succinate metabolic process (GO:0006105)4.14239419
19cellular ketone body metabolic process (GO:0046950)4.10831579
20glandular epithelial cell differentiation (GO:0002067)4.08958075
21vesicle coating (GO:0006901)4.03942196
22signal peptide processing (GO:0006465)4.03506399
23epithelial cell fate commitment (GO:0072148)4.03498196
24type B pancreatic cell development (GO:0003323)3.97411888
25protein retention in ER lumen (GO:0006621)3.90418127
26negative regulation of catecholamine secretion (GO:0033604)3.86291604
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.82159048
28regulation of peptide hormone secretion (GO:0090276)3.80545204
29regulation of synaptic vesicle exocytosis (GO:2000300)3.75826229
30regulation of peptide secretion (GO:0002791)3.75077691
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73707346
32peptide hormone secretion (GO:0030072)3.71938972
33cerebellar Purkinje cell layer development (GO:0021680)3.61325717
34ketone body metabolic process (GO:1902224)3.61145097
35peptide secretion (GO:0002790)3.61035595
36positive regulation of nuclease activity (GO:0032075)3.60178097
37regulation of glucocorticoid secretion (GO:2000849)3.59709440
38negative regulation of norepinephrine secretion (GO:0010700)3.57689078
39neuron cell-cell adhesion (GO:0007158)3.56267118
40intra-Golgi vesicle-mediated transport (GO:0006891)3.55324031
41glandular epithelial cell development (GO:0002068)3.53651380
42sequestering of metal ion (GO:0051238)3.49166788
43exocrine pancreas development (GO:0031017)3.47685298
44inositol phosphate catabolic process (GO:0071545)3.47121765
45toxin metabolic process (GO:0009404)3.47086696
46positive regulation of peptide hormone secretion (GO:0090277)3.43844458
47protein-cofactor linkage (GO:0018065)3.42558337
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41589521
49cellular response to glucagon stimulus (GO:0071377)3.40272281
50nitric oxide mediated signal transduction (GO:0007263)3.38069081
51positive regulation of peptide secretion (GO:0002793)3.37084949
52neurotransmitter biosynthetic process (GO:0042136)3.35829745
53synaptic vesicle exocytosis (GO:0016079)3.34362688
54regulation of hormone secretion (GO:0046883)3.33896564
55water-soluble vitamin biosynthetic process (GO:0042364)3.26534020
56regulation of nuclease activity (GO:0032069)3.23871970
57synaptic vesicle maturation (GO:0016188)3.21264869
58regulation of calcium ion-dependent exocytosis (GO:0017158)3.20320914
59proline transport (GO:0015824)3.18559232
60regulation of synaptic vesicle transport (GO:1902803)3.18336063
61activation of protein kinase A activity (GO:0034199)3.17847862
62phosphorylated carbohydrate dephosphorylation (GO:0046838)3.16704269
63inositol phosphate dephosphorylation (GO:0046855)3.16704269
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15266892
65protein targeting to Golgi (GO:0000042)3.15166492
66nonmotile primary cilium assembly (GO:0035058)3.15124264
67positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.11855588
68endoplasmic reticulum unfolded protein response (GO:0030968)3.10352634
69protein localization to Golgi apparatus (GO:0034067)3.09004759
70cAMP catabolic process (GO:0006198)3.07316155
71inner ear receptor cell development (GO:0060119)3.07066608
72response to pheromone (GO:0019236)3.06209058
73cellular response to unfolded protein (GO:0034620)3.05820804
74ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.05716596
75hormone secretion (GO:0046879)3.05610112
76dendritic spine morphogenesis (GO:0060997)3.03756684
77positive regulation of exocytosis (GO:0045921)3.02912739
78regulation of peptide transport (GO:0090087)3.02488651
79positive regulation of amino acid transport (GO:0051957)2.99807555
80cellular response to topologically incorrect protein (GO:0035967)2.99262848
81nucleobase catabolic process (GO:0046113)2.99168424
82dicarboxylic acid catabolic process (GO:0043649)2.99094157
83ER-nucleus signaling pathway (GO:0006984)2.98144155
84glutamate secretion (GO:0014047)2.97159874
85chemosensory behavior (GO:0007635)2.94286219
86dopamine biosynthetic process (GO:0042416)2.93294608
87neuromuscular process controlling posture (GO:0050884)2.93161886
88negative regulation of execution phase of apoptosis (GO:1900118)2.92918458
89axonal fasciculation (GO:0007413)2.92502517
90alanine transport (GO:0032328)2.90681321
91positive regulation of neurotransmitter transport (GO:0051590)2.90491931
92cyclic nucleotide catabolic process (GO:0009214)2.89786302
93macroautophagy (GO:0016236)2.88998305
94negative regulation of insulin secretion (GO:0046676)2.88703757
95membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.88609565
96regulation of hexokinase activity (GO:1903299)2.88502917
97regulation of glucokinase activity (GO:0033131)2.88502917
98hormone transport (GO:0009914)2.87585080
99regulation of corticosteroid hormone secretion (GO:2000846)2.87546268
100signal release (GO:0023061)2.86964268
101ER to Golgi vesicle-mediated transport (GO:0006888)2.86296544
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.85255181
103protein localization to cilium (GO:0061512)2.84744335
104brain morphogenesis (GO:0048854)2.83441176
105gamma-aminobutyric acid transport (GO:0015812)2.83283389
106regulation of neurotransmitter uptake (GO:0051580)2.83031814
107regulation of exocytosis (GO:0017157)2.81721064
108negative regulation of amine transport (GO:0051953)2.81562829
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80165920
110protein N-linked glycosylation via asparagine (GO:0018279)2.79844677
111regulation of norepinephrine secretion (GO:0014061)2.79111144
112ionotropic glutamate receptor signaling pathway (GO:0035235)2.78751852
113response to corticosterone (GO:0051412)2.78400048
114peptidyl-asparagine modification (GO:0018196)2.78323417
115establishment of protein localization to Golgi (GO:0072600)2.76937267
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76746680
117catechol-containing compound biosynthetic process (GO:0009713)2.76432437
118catecholamine biosynthetic process (GO:0042423)2.76432437
119peptide transport (GO:0015833)2.76235584
120presynaptic membrane assembly (GO:0097105)2.75404861
121mating behavior (GO:0007617)2.75274385
122sulfation (GO:0051923)2.74828435
123positive regulation of hormone secretion (GO:0046887)2.74515054
124positive regulation of mitochondrial fission (GO:0090141)2.74031627
125neurotransmitter secretion (GO:0007269)2.72094072
126response to dietary excess (GO:0002021)2.71598215
127eating behavior (GO:0042755)2.71217781
128positive regulation of histone H3-K4 methylation (GO:0051571)2.70878850
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70002006
130regulation of vesicle fusion (GO:0031338)2.68495717
131negative regulation of peptide hormone secretion (GO:0090278)2.67076892
132regulation of Golgi to plasma membrane protein transport (GO:0042996)2.66854918
133glycosphingolipid biosynthetic process (GO:0006688)2.66437013
134regulation of beta-amyloid formation (GO:1902003)2.65916613
135glutamate receptor signaling pathway (GO:0007215)2.65209010
136negative regulation of glycoprotein biosynthetic process (GO:0010561)2.64652172
137columnar/cuboidal epithelial cell development (GO:0002066)2.64011181
138retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63332438
139astrocyte differentiation (GO:0048708)2.63306602
140regulation of dopamine metabolic process (GO:0042053)2.63210864
141regulation of catecholamine metabolic process (GO:0042069)2.63210864
142negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.63007364
143innervation (GO:0060384)2.62930620
144regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62017647
145pyrimidine nucleobase catabolic process (GO:0006208)2.61671506
146presynaptic membrane organization (GO:0097090)2.61155459
147positive regulation of gluconeogenesis (GO:0045722)2.59277165
148regulation of Rac protein signal transduction (GO:0035020)2.58719322
149calcium ion import (GO:0070509)2.56179035
150locomotory exploration behavior (GO:0035641)2.54875066
151neurotransmitter metabolic process (GO:0042133)2.54268549
152auditory receptor cell differentiation (GO:0042491)2.53520138
153polyol catabolic process (GO:0046174)2.53038315
154neurotransmitter transport (GO:0006836)2.52441587
155synaptic vesicle docking involved in exocytosis (GO:0016081)2.51347504
156regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.51149104
157regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.51149104
158artery smooth muscle contraction (GO:0014824)2.50255191
159catecholamine transport (GO:0051937)2.48926238
160synapse assembly (GO:0007416)2.48260834
161dopamine transport (GO:0015872)2.47094932
162positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.46708116
163regulation of neurotransmitter levels (GO:0001505)2.46600348
164regulation of action potential (GO:0098900)2.45827703
165membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45169284
166melanosome transport (GO:0032402)2.43058065
167C-terminal protein lipidation (GO:0006501)2.41813545
168positive regulation of calcium ion import (GO:0090280)2.41303117
169calcium ion-dependent exocytosis (GO:0017156)2.38732020
170establishment of melanosome localization (GO:0032401)2.38373400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.38004760
2EZH2_22144423_ChIP-Seq_EOC_Human4.84136732
3GBX2_23144817_ChIP-Seq_PC3_Human3.29020828
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.90391433
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42186927
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41464868
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.40077131
8ZNF274_21170338_ChIP-Seq_K562_Hela2.34615184
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34014230
10IGF1R_20145208_ChIP-Seq_DFB_Human2.24567224
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20897302
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17838933
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15578724
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14116400
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03948275
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02353175
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96080201
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.89642648
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88305393
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.86436310
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85528423
22* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.85073870
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.83726803
24TAF15_26573619_Chip-Seq_HEK293_Human1.82338719
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80489980
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80152262
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73948544
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.70379259
29GATA1_22025678_ChIP-Seq_K562_Human1.69359665
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.69241105
31* FLI1_27457419_Chip-Seq_LIVER_Mouse1.69051914
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68553087
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66031763
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65428445
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.65411594
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61711115
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57564933
38STAT3_23295773_ChIP-Seq_U87_Human1.56516075
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.53046624
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52322499
41DROSHA_22980978_ChIP-Seq_HELA_Human1.50327520
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.48474961
43* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47937554
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46260324
45REST_19997604_ChIP-ChIP_NEURONS_Mouse1.45354773
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45144037
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45144037
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43686302
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42531565
50* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42103317
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.41011663
52* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40604971
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40388089
54* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39904836
55P300_19829295_ChIP-Seq_ESCs_Human1.39831469
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.36898628
57* HTT_18923047_ChIP-ChIP_STHdh_Human1.36291727
58EWS_26573619_Chip-Seq_HEK293_Human1.35696946
59VDR_22108803_ChIP-Seq_LS180_Human1.33348468
60ER_23166858_ChIP-Seq_MCF-7_Human1.30066686
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29597341
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29272040
63* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23995513
64CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23512063
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23267539
66TCF4_23295773_ChIP-Seq_U87_Human1.22084388
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21821504
68AR_25329375_ChIP-Seq_VCAP_Human1.20591815
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19277921
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17621126
71* EZH2_27294783_Chip-Seq_NPCs_Mouse1.17390632
72RUNX2_22187159_ChIP-Seq_PCA_Human1.16950114
73BCAT_22108803_ChIP-Seq_LS180_Human1.15763557
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.15221733
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15042584
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14837137
77* CMYC_18555785_Chip-Seq_ESCs_Mouse1.14505128
78* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14084954
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13969369
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.13444567
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13035921
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.10569547
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.10361130
84* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09780874
85* NFE2_27457419_Chip-Seq_LIVER_Mouse1.09039478
86* SMAD3_21741376_ChIP-Seq_ESCs_Human1.08426291
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06334605
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05647350
89* NANOG_18555785_Chip-Seq_ESCs_Mouse1.05567463
90* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04704711
91* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04163693
92* SOX2_18555785_Chip-Seq_ESCs_Mouse1.04032992
93* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03376774
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.03218810
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02972492
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02542321
97* AR_19668381_ChIP-Seq_PC3_Human1.02449981
98NANOG_19829295_ChIP-Seq_ESCs_Human1.01135084
99SOX2_19829295_ChIP-Seq_ESCs_Human1.01135084
100* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00804654
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00750882
102TP53_22573176_ChIP-Seq_HFKS_Human1.00206540
103* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99941723
104RNF2_27304074_Chip-Seq_NSC_Mouse0.99379060
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98791021
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98499094
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97965453
108KDM2B_26808549_Chip-Seq_REH_Human0.97074253
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96849101
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96444579
111FUS_26573619_Chip-Seq_HEK293_Human0.94547061
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93753638
113* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92965265
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91845028
115* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91721888
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91364802
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90623023
118TCF4_22108803_ChIP-Seq_LS180_Human0.88568405
119STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88339455
120* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86998508
121* STAT3_18555785_Chip-Seq_ESCs_Mouse0.86401173
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84782826
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82471146
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.82306795
125* P53_22387025_ChIP-Seq_ESCs_Mouse0.81949330
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81894083
127CBP_20019798_ChIP-Seq_JUKART_Human0.81894083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland4.02220921
2MP0009780_abnormal_chondrocyte_physiolo3.82972510
3MP0002877_abnormal_melanocyte_morpholog3.75216999
4MP0003283_abnormal_digestive_organ3.68590621
5MP0000013_abnormal_adipose_tissue3.48575215
6MP0003122_maternal_imprinting3.46566151
7MP0004043_abnormal_pH_regulation3.36997763
8MP0002693_abnormal_pancreas_physiology3.35963519
9MP0010386_abnormal_urinary_bladder3.15263120
10MP0001944_abnormal_pancreas_morphology2.85111092
11MP0003183_abnormal_peptide_metabolism2.82857551
12MP0005645_abnormal_hypothalamus_physiol2.77157787
13MP0005379_endocrine/exocrine_gland_phen2.75745120
14MP0002837_dystrophic_cardiac_calcinosis2.64159586
15MP0005646_abnormal_pituitary_gland2.63799803
16MP0003195_calcinosis2.39507879
17MP0006072_abnormal_retinal_apoptosis2.35344774
18MP0000678_abnormal_parathyroid_gland2.33567088
19MP0008877_abnormal_DNA_methylation2.22251016
20MP0002876_abnormal_thyroid_physiology2.19085159
21MP0004270_analgesia2.17127319
22MP0002638_abnormal_pupillary_reflex2.00048087
23MP0003635_abnormal_synaptic_transmissio1.99532918
24MP0002078_abnormal_glucose_homeostasis1.95004162
25MP0004859_abnormal_synaptic_plasticity1.91659216
26MP0006276_abnormal_autonomic_nervous1.83041175
27MP0003787_abnormal_imprinting1.79259937
28MP0001986_abnormal_taste_sensitivity1.78679363
29MP0000631_abnormal_neuroendocrine_gland1.77692202
30MP0005220_abnormal_exocrine_pancreas1.68266440
31MP0001502_abnormal_circadian_rhythm1.64546181
32MP0000003_abnormal_adipose_tissue1.61686657
33MP0002572_abnormal_emotion/affect_behav1.60833983
34MP0002734_abnormal_mechanical_nocicepti1.60217415
35MP0002733_abnormal_thermal_nociception1.58534319
36MP0000569_abnormal_digit_pigmentation1.57412089
37MP0002063_abnormal_learning/memory/cond1.52851575
38MP0002272_abnormal_nervous_system1.50413533
39MP0001501_abnormal_sleep_pattern1.49881471
40MP0002139_abnormal_hepatobiliary_system1.47601438
41MP0009745_abnormal_behavioral_response1.45412905
42MP0002064_seizures1.45404450
43MP0002822_catalepsy1.39635779
44MP0004885_abnormal_endolymph1.39419108
45MP0003953_abnormal_hormone_level1.36232204
46MP0008961_abnormal_basal_metabolism1.36058926
47MP0005535_abnormal_body_temperature1.35310631
48MP0003880_abnormal_central_pattern1.33313067
49MP0001970_abnormal_pain_threshold1.33163063
50MP0003172_abnormal_lysosome_physiology1.31278327
51MP0010329_abnormal_lipoprotein_level1.28942838
52MP0001765_abnormal_ion_homeostasis1.22854119
53MP0002557_abnormal_social/conspecific_i1.22478826
54MP0002234_abnormal_pharynx_morphology1.21165306
55MP0003121_genomic_imprinting1.17430633
56MP0009046_muscle_twitch1.14928428
57MP0003879_abnormal_hair_cell1.13007795
58MP0005332_abnormal_amino_acid1.12895824
59MP0003959_abnormal_lean_body1.11303942
60MP0002163_abnormal_gland_morphology1.10283260
61MP0002735_abnormal_chemical_nociception1.10146683
62MP0003123_paternal_imprinting1.09833376
63MP0000681_abnormal_thyroid_gland1.08834743
64MP0004264_abnormal_extraembryonic_tissu1.08522353
65MP0005386_behavior/neurological_phenoty1.06530415
66MP0004924_abnormal_behavior1.06530415
67MP0001756_abnormal_urination1.05991251
68MP0004133_heterotaxia1.05813086
69MP0001188_hyperpigmentation1.05804967
70MP0010234_abnormal_vibrissa_follicle1.05636598
71MP0005253_abnormal_eye_physiology1.05338840
72MP0002896_abnormal_bone_mineralization1.04617758
73MP0003631_nervous_system_phenotype1.04587628
74MP0001440_abnormal_grooming_behavior1.04494553
75MP0005187_abnormal_penis_morphology1.03093753
76MP0002067_abnormal_sensory_capabilities1.03075197
77MP0004019_abnormal_vitamin_homeostasis1.02972242
78MP0001529_abnormal_vocalization1.01257728
79MP0001984_abnormal_olfaction1.00918052
80MP0001968_abnormal_touch/_nociception1.00658754
81MP0002928_abnormal_bile_duct0.99971434
82MP0002102_abnormal_ear_morphology0.99951841
83MP0000462_abnormal_digestive_system0.99830832
84MP0000639_abnormal_adrenal_gland0.99525139
85MP0005448_abnormal_energy_balance0.98568536
86MP0002184_abnormal_innervation0.97276006
87MP0001299_abnormal_eye_distance/0.95327615
88MP0003632_abnormal_nervous_system0.93610427
89MP0003868_abnormal_feces_composition0.93312465
90MP0002090_abnormal_vision0.92805675
91MP0000516_abnormal_urinary_system0.92248935
92MP0005367_renal/urinary_system_phenotyp0.92248935
93MP0001486_abnormal_startle_reflex0.90041243
94MP0004215_abnormal_myocardial_fiber0.89777109
95MP0005423_abnormal_somatic_nervous0.89741251
96MP0002736_abnormal_nociception_after0.89066489
97MP0000955_abnormal_spinal_cord0.88906113
98MP0002069_abnormal_eating/drinking_beha0.88417398
99MP0005551_abnormal_eye_electrophysiolog0.88190161
100MP0004145_abnormal_muscle_electrophysio0.85123966
101MP0001270_distended_abdomen0.85038228
102MP0000427_abnormal_hair_cycle0.84319316
103MP0005058_abnormal_lysosome_morphology0.83934072
104MP0002229_neurodegeneration0.83886330
105MP0003329_amyloid_beta_deposits0.83644674
106MP0004811_abnormal_neuron_physiology0.82423412
107MP0003011_delayed_dark_adaptation0.82132903
108MP0000613_abnormal_salivary_gland0.79309635
109MP0005310_abnormal_salivary_gland0.78712656
110MP0008569_lethality_at_weaning0.77494623
111MP0000230_abnormal_systemic_arterial0.76520319
112MP0004085_abnormal_heartbeat0.76432153
113MP0002066_abnormal_motor_capabilities/c0.76274199
114MP0005636_abnormal_mineral_homeostasis0.75086507
115MP0001664_abnormal_digestion0.74739044
116MP0008872_abnormal_physiological_respon0.74056361
117MP0002882_abnormal_neuron_morphology0.72785426
118MP0002254_reproductive_system_inflammat0.71673209
119MP0001905_abnormal_dopamine_level0.68967844
120MP0000538_abnormal_urinary_bladder0.68773648
121MP0004142_abnormal_muscle_tone0.68299215
122MP0003634_abnormal_glial_cell0.66978150
123MP0003633_abnormal_nervous_system0.66159557

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.01158298
2Hyperinsulinemic hypoglycemia (HP:0000825)6.46999391
3Hypoglycemic seizures (HP:0002173)5.84323821
4Symptomatic seizures (HP:0011145)5.46473086
5Abnormality of calcium-phosphate metabolism (HP:0100530)4.61455563
6Hypoglycemic coma (HP:0001325)4.45501257
7Insulin-resistant diabetes mellitus (HP:0000831)4.18617686
8Agitation (HP:0000713)4.00496497
9Hyperglycemia (HP:0003074)3.90936453
10Intestinal atresia (HP:0011100)3.88099859
11Decreased circulating renin level (HP:0003351)3.79452785
12Visual hallucinations (HP:0002367)3.76904219
13Abnormality of the pancreatic islet cells (HP:0006476)3.73286177
14Abnormality of endocrine pancreas physiology (HP:0012093)3.73286177
15Large for gestational age (HP:0001520)3.56489233
16Pancreatic islet-cell hyperplasia (HP:0004510)3.50892015
17Ketoacidosis (HP:0001993)3.50093587
18Pheochromocytoma (HP:0002666)3.48641885
19Menstrual irregularities (HP:0000858)3.42941241
20Hemiparesis (HP:0001269)3.26321454
21Failure to thrive in infancy (HP:0001531)3.24076049
22Hypothermia (HP:0002045)3.22296383
23Abnormal pancreas size (HP:0012094)3.20119972
24Late onset (HP:0003584)3.15494639
25Congenital malformation of the right heart (HP:0011723)3.11822686
26Double outlet right ventricle (HP:0001719)3.11822686
27Neuroendocrine neoplasm (HP:0100634)3.07842211
28Hyperparathyroidism (HP:0000843)2.96516035
29EEG with generalized epileptiform discharges (HP:0011198)2.95862721
30Papilledema (HP:0001085)2.92632480
31Hypercortisolism (HP:0001578)2.90851274
32Polyphagia (HP:0002591)2.90390199
33Hypokalemia (HP:0002900)2.88615151
34Epileptiform EEG discharges (HP:0011182)2.88551829
35Mucopolysacchariduria (HP:0008155)2.87213732
36Urinary glycosaminoglycan excretion (HP:0003541)2.87213732
37Hypsarrhythmia (HP:0002521)2.86182388
38Dysostosis multiplex (HP:0000943)2.81453009
39Atonic seizures (HP:0010819)2.77833337
40Osteomalacia (HP:0002749)2.75198141
41Abnormality of vitamin B metabolism (HP:0004340)2.68693655
42Hyperventilation (HP:0002883)2.66119254
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65436964
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65436964
45Abnormality of polysaccharide metabolism (HP:0011012)2.65436964
46Proximal tubulopathy (HP:0000114)2.54339750
47Abnormality of renin-angiotensin system (HP:0000847)2.52148472
48Hypokinesia (HP:0002375)2.51594082
49Oligomenorrhea (HP:0000876)2.50878907
50Growth hormone excess (HP:0000845)2.49683789
51Focal motor seizures (HP:0011153)2.47116234
52Generalized aminoaciduria (HP:0002909)2.45503826
53Absence seizures (HP:0002121)2.45492618
54Retinal atrophy (HP:0001105)2.39703630
55Dysautonomia (HP:0002459)2.33493388
56Abnormality of vitamin metabolism (HP:0100508)2.31562605
57Restlessness (HP:0000711)2.29938986
58Abnormality of potassium homeostasis (HP:0011042)2.29034364
59Diminished movement (HP:0002374)2.28707913
60Anxiety (HP:0000739)2.28570255
61Nephronophthisis (HP:0000090)2.27135354
623-Methylglutaconic aciduria (HP:0003535)2.27048786
63Macroorchidism (HP:0000053)2.26242609
64Gaze-evoked nystagmus (HP:0000640)2.26077599
65Conjugated hyperbilirubinemia (HP:0002908)2.25233741
66Progressive cerebellar ataxia (HP:0002073)2.24929876
67Abnormality of the intrinsic pathway (HP:0010989)2.22629710
68Enlarged penis (HP:0000040)2.20547436
69Spastic tetraplegia (HP:0002510)2.19992896
70Increased CSF protein (HP:0002922)2.18407309
71Pancreatic fibrosis (HP:0100732)2.17722917
72Limb dystonia (HP:0002451)2.17661510
73Testicular neoplasm (HP:0010788)2.16992756
74Genital tract atresia (HP:0001827)2.16942863
75Limb hypertonia (HP:0002509)2.15060794
76Dialeptic seizures (HP:0011146)2.13760798
77Depression (HP:0000716)2.13386701
78Progressive macrocephaly (HP:0004481)2.12773570
79Adrenal overactivity (HP:0002717)2.12455934
80Cortical visual impairment (HP:0100704)2.12281807
81Insulin resistance (HP:0000855)2.12224758
82Methylmalonic acidemia (HP:0002912)2.10926267
83Poor suck (HP:0002033)2.10663442
84Glycosuria (HP:0003076)2.09273269
85Abnormality of urine glucose concentration (HP:0011016)2.09273269
86Abnormal eating behavior (HP:0100738)2.08081227
87Generalized tonic-clonic seizures (HP:0002069)2.07534821
88Hyperphosphatemia (HP:0002905)2.05172873
89Prominent metopic ridge (HP:0005487)2.03403396
90Vaginal atresia (HP:0000148)2.03313256
91Unilateral renal agenesis (HP:0000122)2.03297248
92Epileptic encephalopathy (HP:0200134)2.02269661
93Pancreatic cysts (HP:0001737)2.01727174
94Molar tooth sign on MRI (HP:0002419)2.01528886
95Abnormality of midbrain morphology (HP:0002418)2.01528886
96Syncope (HP:0001279)2.01435867
97Increased circulating renin level (HP:0000848)2.00527330
98Hyperkalemia (HP:0002153)2.00523450
99Resting tremor (HP:0002322)1.99684629
100Truncal ataxia (HP:0002078)1.99027305
101Type II lissencephaly (HP:0007260)1.98871622
102Hypoalbuminemia (HP:0003073)1.98587944
103Abnormal albumin level (HP:0012116)1.98587944
104Postural tremor (HP:0002174)1.97655711
105Focal seizures (HP:0007359)1.97528954
106Poor coordination (HP:0002370)1.96360697
107Generalized myoclonic seizures (HP:0002123)1.95788961
108Prominent supraorbital ridges (HP:0000336)1.95066756
109Vascular calcification (HP:0004934)1.92377081
110Acute necrotizing encephalopathy (HP:0006965)1.92021148
111Gait imbalance (HP:0002141)1.90949218
112Abnormality of the fovea (HP:0000493)1.88888068
113Hypoplasia of the fovea (HP:0007750)1.88020536
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.88020536
115Hyperactive renin-angiotensin system (HP:0000841)1.87942801
116Renal Fanconi syndrome (HP:0001994)1.86148852
117Medial flaring of the eyebrow (HP:0010747)1.84738209
118Muscular hypotonia of the trunk (HP:0008936)1.84726482
119Focal dystonia (HP:0004373)1.84079152
120Progressive neurologic deterioration (HP:0002344)1.83713575
121Lissencephaly (HP:0001339)1.83183154
122Hypotension (HP:0002615)1.83167363
123True hermaphroditism (HP:0010459)1.82684390
124Hypogonadotrophic hypogonadism (HP:0000044)1.80951493
125Congenital primary aphakia (HP:0007707)1.80516796
126Aplasia/Hypoplasia of the lens (HP:0008063)1.80258098
127Abnormal drinking behavior (HP:0030082)1.79810191
128Polydipsia (HP:0001959)1.79810191
129Abnormality of renal resorption (HP:0011038)1.78834209
130Exocrine pancreatic insufficiency (HP:0001738)1.78713313
131Tongue fasciculations (HP:0001308)1.78671765
132Hypophosphatemia (HP:0002148)1.78473021
133Specific learning disability (HP:0001328)1.78329492
134Amblyopia (HP:0000646)1.78247052
135Psychosis (HP:0000709)1.77775858
136Abnormality of the renal medulla (HP:0100957)1.77500876
137Left ventricular hypertrophy (HP:0001712)1.76212895
138Absent speech (HP:0001344)1.75936507
139Intention tremor (HP:0002080)1.75500084
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74901766
141Hyperthyroidism (HP:0000836)1.73887187
142Neoplasm of the heart (HP:0100544)1.72211615
143Gout (HP:0001997)1.70108822
144Congenital glaucoma (HP:0001087)1.68762825
145Ketosis (HP:0001946)1.68705909
146Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68390241
147Abnormality of the metopic suture (HP:0005556)1.68265992
148Chronic bronchitis (HP:0004469)1.67271858
149Abnormal hair whorl (HP:0010721)1.67066794
150Type II diabetes mellitus (HP:0005978)1.66875019
151Hypocalcemia (HP:0002901)1.65977235
152Febrile seizures (HP:0002373)1.63516350
153Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62756233
154Nephrogenic diabetes insipidus (HP:0009806)1.62537416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.03478755
2PASK4.46701463
3NTRK33.88315665
4PRKD33.22702904
5TAOK33.07419264
6MAPK152.99456175
7MAP3K22.96867355
8PHKG12.95737390
9PHKG22.95737390
10HIPK22.66746991
11STK38L2.38317359
12FRK2.28849625
13UHMK12.28558470
14NTRK12.22639855
15MAP4K22.22465328
16FGFR22.02400524
17CSNK1G31.99752061
18CSNK1G11.99624840
19CAMKK21.96126879
20PINK11.91915433
21AKT31.81553355
22GRK11.80725732
23MAP3K41.79514107
24MAP3K11.79314677
25WNK41.76154196
26WNK31.73105740
27SCYL21.71573024
28CDC42BPA1.56776414
29MAP2K61.51343833
30MAP2K71.42462228
31CSNK1A1L1.38563521
32PAK31.37058028
33MARK11.32384144
34GRK51.29642373
35PRKCH1.29055756
36MAP3K91.28339006
37MST41.25321143
38IRAK31.20139278
39FLT31.19673496
40STK381.16730471
41PNCK1.15900378
42GRK71.15061994
43LMTK21.11256504
44IRAK11.10538741
45MAP3K121.10028776
46CASK1.07741831
47MINK11.03763066
48MAP2K41.01929176
49KSR21.01865753
50IRAK21.01752447
51FGFR30.99431657
52ACVR1B0.96721941
53BRAF0.96186409
54RET0.94679583
55CDK50.94139800
56CAMK2D0.91741692
57PTK20.90467096
58PDGFRA0.90173575
59TRPM70.89323352
60PRKCZ0.89240409
61PRKCE0.89101308
62TNIK0.87212890
63EPHA30.81163012
64OXSR10.81073662
65BRSK20.80498095
66CAMKK10.80472171
67CAMK2A0.77208136
68BCR0.76731785
69NTRK20.76337652
70FER0.76163822
71BMPR20.75971981
72PRKCG0.75224353
73CAMK2B0.73382979
74ERN10.73370609
75PAK60.72489411
76ADRBK10.72141194
77TRIM280.71285602
78MAPK130.70766700
79DYRK20.69776333
80PRKD20.69456978
81LIMK10.68982623
82SGK2230.68677353
83SGK4940.68677353
84WNK10.67186816
85BRSK10.62770750
86DYRK1A0.59249866
87ARAF0.58878370
88PTK2B0.58876259
89STK30.58818926
90CAMK1G0.58168701
91DYRK1B0.57006548
92MKNK20.56920835
93SGK20.56532113
94CSNK1G20.56434050
95TAOK10.56185833
96RPS6KA20.56180353
97NME10.56160037
98EPHA40.55619093
99NLK0.55594071
100CSNK1D0.52593883
101BMPR1B0.50092243
102EIF2AK30.49946731
103PRKAA10.48517945
104PRKG10.48499585
105STK390.47453693
106CAMK2G0.47435096
107PRKACA0.47248831
108SGK10.44967789
109ADRBK20.44744456
110SIK20.44681583
111PRKACB0.43939036
112CSNK1E0.43295384
113RPS6KB10.43202568
114PLK20.42372901
115PRKACG0.42345671
116ERBB30.41652463
117CSNK1A10.41555762
118STK110.40488096
119MARK20.40183114
120BRD40.39667329
121GSK3A0.39589098
122STK240.38560354
123PTK60.38366964
124RPS6KA30.37918197
125JAK20.36404842
126MAPK100.35768445
127PRKCA0.35274252
128KSR10.33752930
129PRKCI0.33388639
130MET0.32660310
131PRKCB0.31169116
132CDK140.30528401
133SGK30.29552911
134MAP2K10.29086944
135RPS6KA50.28400493
136DAPK10.28019881
137DAPK20.27609657
138IGF1R0.26386701
139PRKDC0.25582851

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.64185892
2Protein export_Homo sapiens_hsa030604.22449308
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.17641985
4Insulin secretion_Homo sapiens_hsa049113.36337299
5Vibrio cholerae infection_Homo sapiens_hsa051102.53781695
6Sulfur metabolism_Homo sapiens_hsa009202.45767316
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.40958358
8Synaptic vesicle cycle_Homo sapiens_hsa047212.40814839
9Type II diabetes mellitus_Homo sapiens_hsa049302.29448289
10Type I diabetes mellitus_Homo sapiens_hsa049402.28791879
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26610222
12Cocaine addiction_Homo sapiens_hsa050302.20039406
13Collecting duct acid secretion_Homo sapiens_hsa049662.07021559
14Amphetamine addiction_Homo sapiens_hsa050312.05574390
15GABAergic synapse_Homo sapiens_hsa047271.90072902
16Taste transduction_Homo sapiens_hsa047421.75415390
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73548542
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71098309
19Nicotine addiction_Homo sapiens_hsa050331.68682022
20Dopaminergic synapse_Homo sapiens_hsa047281.67715448
21Circadian entrainment_Homo sapiens_hsa047131.66240686
22Serotonergic synapse_Homo sapiens_hsa047261.58328520
23beta-Alanine metabolism_Homo sapiens_hsa004101.56252016
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55866962
25Long-term potentiation_Homo sapiens_hsa047201.55552545
26Morphine addiction_Homo sapiens_hsa050321.52071284
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.51893146
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51729848
29Cholinergic synapse_Homo sapiens_hsa047251.35010474
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34622276
31N-Glycan biosynthesis_Homo sapiens_hsa005101.33023781
32Folate biosynthesis_Homo sapiens_hsa007901.20964743
33Thyroid hormone synthesis_Homo sapiens_hsa049181.17814109
34Glutamatergic synapse_Homo sapiens_hsa047241.14983178
35Vitamin B6 metabolism_Homo sapiens_hsa007501.13924098
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12810258
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12127308
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10398197
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09258788
40Circadian rhythm_Homo sapiens_hsa047101.09161795
41Lysosome_Homo sapiens_hsa041421.07821684
42Renin secretion_Homo sapiens_hsa049241.04639422
43Pancreatic secretion_Homo sapiens_hsa049721.03552245
44Glucagon signaling pathway_Homo sapiens_hsa049220.99411369
45Long-term depression_Homo sapiens_hsa047300.98745830
46Olfactory transduction_Homo sapiens_hsa047400.96513881
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95282792
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93823909
49Ether lipid metabolism_Homo sapiens_hsa005650.92674368
50Estrogen signaling pathway_Homo sapiens_hsa049150.89150566
51Regulation of autophagy_Homo sapiens_hsa041400.86061156
52GnRH signaling pathway_Homo sapiens_hsa049120.83472693
53Prion diseases_Homo sapiens_hsa050200.82912962
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.82835940
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82288494
56Oxidative phosphorylation_Homo sapiens_hsa001900.81199233
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78974918
58Gastric acid secretion_Homo sapiens_hsa049710.78683162
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77684840
60Peroxisome_Homo sapiens_hsa041460.77670270
61Fatty acid elongation_Homo sapiens_hsa000620.77570650
62Salivary secretion_Homo sapiens_hsa049700.76534862
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.76024523
64Butanoate metabolism_Homo sapiens_hsa006500.74551069
65Prolactin signaling pathway_Homo sapiens_hsa049170.72086398
66Ovarian steroidogenesis_Homo sapiens_hsa049130.70821582
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70703496
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65220063
69Alcoholism_Homo sapiens_hsa050340.65210117
70cAMP signaling pathway_Homo sapiens_hsa040240.65177032
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64704586
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63505274
73Propanoate metabolism_Homo sapiens_hsa006400.62242061
74Alzheimers disease_Homo sapiens_hsa050100.61849026
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61319230
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60926999
77Dorso-ventral axis formation_Homo sapiens_hsa043200.58574490
78Gap junction_Homo sapiens_hsa045400.58537073
79Galactose metabolism_Homo sapiens_hsa000520.55993378
80Nitrogen metabolism_Homo sapiens_hsa009100.55765597
81Insulin resistance_Homo sapiens_hsa049310.55085215
82Oxytocin signaling pathway_Homo sapiens_hsa049210.54386827
83Insulin signaling pathway_Homo sapiens_hsa049100.54363816
84Calcium signaling pathway_Homo sapiens_hsa040200.53976207
85Fatty acid metabolism_Homo sapiens_hsa012120.52996067
86Other glycan degradation_Homo sapiens_hsa005110.51959028
87Selenocompound metabolism_Homo sapiens_hsa004500.51684821
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50222572
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50040640
90Arginine biosynthesis_Homo sapiens_hsa002200.49124219
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48191626
92Melanogenesis_Homo sapiens_hsa049160.47343823
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45888289
94Phenylalanine metabolism_Homo sapiens_hsa003600.45666020
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45317573
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44899188
97Parkinsons disease_Homo sapiens_hsa050120.44613414
98Oocyte meiosis_Homo sapiens_hsa041140.43730484
99Mineral absorption_Homo sapiens_hsa049780.42325483
100Phototransduction_Homo sapiens_hsa047440.41599263
101Inositol phosphate metabolism_Homo sapiens_hsa005620.41453347
102Metabolic pathways_Homo sapiens_hsa011000.40407741
103Sphingolipid metabolism_Homo sapiens_hsa006000.40348309
104Rheumatoid arthritis_Homo sapiens_hsa053230.39139215
105mTOR signaling pathway_Homo sapiens_hsa041500.39121088
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38121403
107Phagosome_Homo sapiens_hsa041450.37405391
108ABC transporters_Homo sapiens_hsa020100.37403888
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36946364
110Cardiac muscle contraction_Homo sapiens_hsa042600.36525132
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35257509
112Huntingtons disease_Homo sapiens_hsa050160.34226556
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32516036
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31871242
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31218549
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27739013
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27021513
118Linoleic acid metabolism_Homo sapiens_hsa005910.26558227
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.26307755
120Basal transcription factors_Homo sapiens_hsa030220.26114016
121Tyrosine metabolism_Homo sapiens_hsa003500.25708682
122Glioma_Homo sapiens_hsa052140.25414943
123MAPK signaling pathway_Homo sapiens_hsa040100.24566697
124AMPK signaling pathway_Homo sapiens_hsa041520.24495330
125Tryptophan metabolism_Homo sapiens_hsa003800.24217316
126Dilated cardiomyopathy_Homo sapiens_hsa054140.23843337
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22981926
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22894636

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