SCGB1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.51271379
2regulation of cilium movement (GO:0003352)8.55024895
3positive regulation of endothelial cell differentiation (GO:0045603)8.03247563
4left/right axis specification (GO:0070986)7.60549300
5regulation of endothelial cell differentiation (GO:0045601)7.26072751
6ventricular system development (GO:0021591)7.24913429
7primary alcohol catabolic process (GO:0034310)7.10937684
8vitamin transmembrane transport (GO:0035461)6.99971403
9blood vessel maturation (GO:0001955)6.94931131
10morphogenesis of an endothelium (GO:0003159)6.78321060
11endothelial tube morphogenesis (GO:0061154)6.78321060
12microtubule bundle formation (GO:0001578)6.66045139
13intraciliary transport (GO:0042073)6.38052187
14regulation of vasculogenesis (GO:2001212)6.21815269
15cilium organization (GO:0044782)6.03930860
16cellular response to nitric oxide (GO:0071732)5.97263063
17lymphangiogenesis (GO:0001946)5.88249766
18cilium assembly (GO:0042384)5.86314761
19tolerance induction (GO:0002507)5.65567997
20positive regulation of vasculogenesis (GO:2001214)5.45522063
21lung lobe morphogenesis (GO:0060463)5.32965319
22lung vasculature development (GO:0060426)5.28900625
23pyrimidine-containing compound transmembrane transport (GO:0072531)5.23845585
24lung epithelium development (GO:0060428)5.21133514
25establishment of apical/basal cell polarity (GO:0035089)5.12652644
26centriole assembly (GO:0098534)5.03372112
27diterpenoid biosynthetic process (GO:0016102)5.03098906
28negative regulation of T cell differentiation in thymus (GO:0033085)4.96427991
29regulation of microtubule-based movement (GO:0060632)4.96037536
30protein localization to cilium (GO:0061512)4.94427529
31negative regulation of immunoglobulin mediated immune response (GO:0002890)4.93953550
32negative regulation of B cell mediated immunity (GO:0002713)4.93953550
33sodium ion homeostasis (GO:0055078)4.91075798
34microtubule-based movement (GO:0007018)4.88338959
35glomerular epithelial cell development (GO:0072310)4.87528733
36respiratory tube development (GO:0030323)4.85501910
37negative regulation of humoral immune response (GO:0002921)4.82317061
38cellular component assembly involved in morphogenesis (GO:0010927)4.64500734
39artery development (GO:0060840)4.64236483
40regulation of germinal center formation (GO:0002634)4.59735046
41positive regulation of tolerance induction (GO:0002645)4.52399107
42cellular response to reactive nitrogen species (GO:1902170)4.51997867
43endothelial cell differentiation (GO:0045446)4.45682226
44negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.44541440
45establishment or maintenance of monopolar cell polarity (GO:0061339)4.42874720
46establishment of monopolar cell polarity (GO:0061162)4.42874720
47response to nitric oxide (GO:0071731)4.42634603
48sperm capacitation (GO:0048240)4.40095647
49toxin metabolic process (GO:0009404)4.37971663
50blood vessel remodeling (GO:0001974)4.28853013
51cell projection assembly (GO:0030031)4.28815865
52cilium morphogenesis (GO:0060271)4.20140347
53lymph vessel development (GO:0001945)4.15498798
54polarized epithelial cell differentiation (GO:0030859)4.10806178
55hormone catabolic process (GO:0042447)4.06604749
56negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.05341500
57nucleoside diphosphate phosphorylation (GO:0006165)3.96731676
58vascular endothelial growth factor signaling pathway (GO:0038084)3.89347303
59cytoplasmic microtubule organization (GO:0031122)3.87099409
60negative regulation of inclusion body assembly (GO:0090084)3.86467216
61endocardial cushion development (GO:0003197)3.85310356
62mesodermal cell differentiation (GO:0048333)3.84117351
63peptide catabolic process (GO:0043171)3.78945601
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.78825909
65microtubule depolymerization (GO:0007019)3.76472184
66renal filtration (GO:0097205)3.76103388
67dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.74474126
68wound healing, spreading of epidermal cells (GO:0035313)3.68706576
69epithelial tube branching involved in lung morphogenesis (GO:0060441)3.62101580
70embryonic foregut morphogenesis (GO:0048617)3.61468823
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.56401093
72microtubule polymerization or depolymerization (GO:0031109)3.51760078
73establishment of planar polarity (GO:0001736)3.51017124
74establishment of tissue polarity (GO:0007164)3.51017124
75respiratory gaseous exchange (GO:0007585)3.45386129
76endothelial cell chemotaxis (GO:0035767)3.44742485
77terpenoid biosynthetic process (GO:0016114)3.44569993
78regulation of tolerance induction (GO:0002643)3.41479351
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.39101079
80retinoic acid metabolic process (GO:0042573)3.38799904
81regulation of glomerular filtration (GO:0003093)3.34063294
82midgut development (GO:0007494)3.33385732
83lung alveolus development (GO:0048286)3.32397391
84positive regulation of smoothened signaling pathway (GO:0045880)3.28223685
85regulation of integrin-mediated signaling pathway (GO:2001044)3.28091843
86adhesion of symbiont to host cell (GO:0044650)3.27994863
87virion attachment to host cell (GO:0019062)3.27994863
88one-carbon compound transport (GO:0019755)3.26986675
89cell adhesion mediated by integrin (GO:0033627)3.25448123
90induction of positive chemotaxis (GO:0050930)3.25393568
91aldehyde catabolic process (GO:0046185)3.25304818
92glomerular filtration (GO:0003094)3.21468438
93venous blood vessel morphogenesis (GO:0048845)3.19580139
94multicellular organismal water homeostasis (GO:0050891)3.18634940
95epoxygenase P450 pathway (GO:0019373)3.16154550
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15074792
97sodium-independent organic anion transport (GO:0043252)3.12495232
98establishment of epithelial cell polarity (GO:0090162)3.12336152
99negative regulation of focal adhesion assembly (GO:0051895)3.12186438
100negative regulation of cell junction assembly (GO:1901889)3.12186438
101negative regulation of adherens junction organization (GO:1903392)3.12186438
102retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09826461
103peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.07466816
104O-glycan processing (GO:0016266)3.06671830
105primary alcohol metabolic process (GO:0034308)3.05593383
106glutathione derivative biosynthetic process (GO:1901687)3.05527962
107glutathione derivative metabolic process (GO:1901685)3.05527962
108basement membrane organization (GO:0071711)3.02465453
109gas transport (GO:0015669)3.00703695
110regulation of microtubule depolymerization (GO:0031114)3.00470977
111axonemal dynein complex assembly (GO:0070286)22.7864864
112determination of left/right symmetry (GO:0007368)2.97829054
113carnitine metabolic process (GO:0009437)2.97614959
114positive regulation of p38MAPK cascade (GO:1900745)2.96128677
115stress fiber assembly (GO:0043149)2.95991375
116endothelial cell morphogenesis (GO:0001886)2.95930525
117apical protein localization (GO:0045176)2.94465416
118lateral sprouting from an epithelium (GO:0060601)2.93964485
119negative regulation of endothelial cell proliferation (GO:0001937)2.93039933
120regulation of axon extension involved in axon guidance (GO:0048841)2.92638578
121positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.92623793
122response to vitamin A (GO:0033189)2.92091551
123hydrogen peroxide biosynthetic process (GO:0050665)2.91858523
124phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.91626503
125adhesion of symbiont to host (GO:0044406)2.89339126
126lung morphogenesis (GO:0060425)2.88515769
127vasculature development (GO:0001944)2.87362779
128vasculogenesis (GO:0001570)2.86723875
129determination of bilateral symmetry (GO:0009855)2.86469000
130axon extension involved in axon guidance (GO:0048846)2.85964708
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.85964708
132microtubule-based process (GO:0007017)2.85750516
133establishment of endothelial barrier (GO:0061028)2.83904223
134endothelial cell proliferation (GO:0001935)2.81790471
135phenylpropanoid metabolic process (GO:0009698)2.81579483
136drug catabolic process (GO:0042737)2.81510582
137exogenous drug catabolic process (GO:0042738)2.81371658
138iron ion import (GO:0097286)2.80753225
139specification of symmetry (GO:0009799)2.80217863
140renal system development (GO:0072001)2.80192626
141regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79468501
142regulation of endothelial cell chemotaxis (GO:2001026)2.79067296
143phosphate ion transmembrane transport (GO:0035435)2.78609632
144endocardial cushion morphogenesis (GO:0003203)2.77138656
145cell migration involved in sprouting angiogenesis (GO:0002042)2.76092630
146regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.73681613
147drug metabolic process (GO:0017144)2.73543833
148ganglion development (GO:0061548)2.73403480
149regulation of apoptotic cell clearance (GO:2000425)2.73138426
150response to increased oxygen levels (GO:0036296)2.72433466
151response to hyperoxia (GO:0055093)2.72433466
152negative regulation of mast cell activation (GO:0033004)2.72369842
153coronary vasculature morphogenesis (GO:0060977)2.72121917
154water homeostasis (GO:0030104)2.71740366
155lateral ventricle development (GO:0021670)2.70288298
156hydrogen peroxide catabolic process (GO:0042744)2.69165968
157sperm motility (GO:0030317)2.68335074
158renal system process involved in regulation of blood volume (GO:0001977)2.67945889
159calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.67558573
160regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.67286415
161ethanol metabolic process (GO:0006067)2.66763409
162phosphatidylcholine biosynthetic process (GO:0006656)2.66198776
163ethanol oxidation (GO:0006069)2.64007164
164retinal rod cell development (GO:0046548)2.63689846
165hypotonic response (GO:0006971)2.63376171
166smoothened signaling pathway (GO:0007224)2.62864568
167regulation of response to osmotic stress (GO:0047484)2.62180050
168retinol metabolic process (GO:0042572)2.61180278
169organelle assembly (GO:0070925)2.60166791
170reactive oxygen species biosynthetic process (GO:1903409)2.59458327
171centriole replication (GO:0007099)2.54230488
172regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.53727853
173carnitine transmembrane transport (GO:1902603)2.49414678
174CDP-diacylglycerol biosynthetic process (GO:0016024)2.48961661
175regulation of autophagic vacuole assembly (GO:2000785)2.48070813
176heart looping (GO:0001947)2.47880677
177establishment or maintenance of apical/basal cell polarity (GO:0035088)2.47846205
178establishment or maintenance of bipolar cell polarity (GO:0061245)2.47846205
179excretion (GO:0007588)2.44442033
180negative regulation of microtubule depolymerization (GO:0007026)2.44028590
181polyol transport (GO:0015791)2.42329216
182cilium or flagellum-dependent cell motility (GO:0001539)19.4948178
183cilium movement (GO:0003341)16.4544336
184motile cilium assembly (GO:0044458)15.3777290
185epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.2167195
186surfactant homeostasis (GO:0043129)14.1117283
187epithelial cilium movement (GO:0003351)13.6876440
188chemical homeostasis within a tissue (GO:0048875)11.2113981
189axoneme assembly (GO:0035082)10.3692779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.03482770
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.17704660
3DROSHA_22980978_ChIP-Seq_HELA_Human3.61830764
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.56278601
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.44141693
6CLOCK_20551151_ChIP-Seq_293T_Human3.33450972
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.18444292
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15451463
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.88087761
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83968678
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.83050430
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66589983
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.46340574
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.36010176
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.21072142
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.08800242
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00720784
18STAT1_20625510_ChIP-Seq_HELA_Human1.91847649
19FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.90064020
20* SMC4_20622854_ChIP-Seq_HELA_Human1.83814067
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.83263853
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83262438
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.80472147
24SOX2_20726797_ChIP-Seq_SW620_Human1.76032808
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.73972452
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72635314
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.71491597
28TP63_23658742_ChIP-Seq_EP156T_Human1.69796869
29AHR_22903824_ChIP-Seq_MCF-7_Human1.65263363
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62198231
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61196480
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60781895
33PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.58320727
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58313173
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58253289
36RACK7_27058665_Chip-Seq_MCF-7_Human1.57007687
37TP63_22573176_ChIP-Seq_HFKS_Human1.55238261
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55151647
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55055962
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53972116
41VDR_22108803_ChIP-Seq_LS180_Human1.52922733
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.52485445
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.52485445
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52479759
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51255788
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50570766
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49634053
48* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49536129
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47447433
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45970688
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.44322331
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43445921
53ETV1_20927104_ChIP-Seq_GIST48_Human1.42509689
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42076093
55* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41404416
56FOXA1_25552417_ChIP-Seq_VCAP_Human1.41311651
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40246327
58CJUN_26792858_Chip-Seq_BT549_Human1.39699164
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.39335286
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.38355666
61* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.37761352
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37230421
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36741212
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36350131
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35887702
66SMRT_27268052_Chip-Seq_Bcells_Human1.34605976
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34221394
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33654539
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33358487
70LXR_22292898_ChIP-Seq_THP-1_Human1.31659335
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30540294
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30315893
73* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30165478
74ZNF263_19887448_ChIP-Seq_K562_Human1.29732359
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29555862
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29549093
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.28931664
78PHF8_20622853_ChIP-Seq_HELA_Human1.28566086
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28341635
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.27180288
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.26353316
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26089716
83* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25650287
84GATA4_25053715_ChIP-Seq_YYC3_Human1.25179799
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21168235
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20581989
87RBPJ_21746931_ChIP-Seq_IB4_Human1.18738433
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17958812
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17225323
90CTCF_27219007_Chip-Seq_Bcells_Human1.16814172
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16783104
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.16193827
93CTCF_20526341_ChIP-Seq_ESCs_Human1.15580534
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13468213
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13468213
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12550190
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12460064
98* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12234390
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11643117
100* GATA1_19941826_ChIP-Seq_K562_Human1.11515293
101GATA3_24758297_ChIP-Seq_MCF-7_Human1.11164511
102CREB1_26743006_Chip-Seq_LNCaP_Human1.10833927
103KDM2B_26808549_Chip-Seq_K562_Human1.09652858
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.09002396
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08599991
106CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08163615
107TP63_17297297_ChIP-ChIP_HaCaT_Human1.07733566
108GATA6_21074721_ChIP-Seq_CACO-2_Human1.07503037
109* P68_20966046_ChIP-Seq_HELA_Human1.06666975
110GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06458314
111* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05777696
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.05009391
113RXR_22158963_ChIP-Seq_LIVER_Mouse1.04622102
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04180917
115SPI1_23127762_ChIP-Seq_K562_Human1.03347595
116NFYA_21822215_ChIP-Seq_K562_Human1.03223954
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03153902
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02433728
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01931825
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01347201
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01050352
122* TP53_18474530_ChIP-ChIP_U2OS_Human1.00985336
123P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00849309
124RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00351074
125EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00351074
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00140194
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99865696
128SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99759179
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99443769
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98603613
131SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97958754
132CEBPB_22108803_ChIP-Seq_LS180_Human0.97506026
133FLI1_21867929_ChIP-Seq_CD8_Mouse0.97300442
134NFYB_21822215_ChIP-Seq_K562_Human0.97088059
135KLF5_25053715_ChIP-Seq_YYC3_Human0.97066142
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96580489
137* YY1_22570637_ChIP-Seq_MALME-3M_Human0.96113599
138AR_21572438_ChIP-Seq_LNCaP_Human0.95618398
139* PHF8_20622854_ChIP-Seq_HELA_Human0.95174105
140TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94686394
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94124494
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.93960165
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93682919
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92795713
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92547586
146WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92036739
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91922831
148TBL1_22424771_ChIP-Seq_293T_Human0.90992519
149* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90403772
150SOX2_21211035_ChIP-Seq_LN229_Human0.90068805
151EGR1_19374776_ChIP-ChIP_THP-1_Human0.89326479
152* GATA2_19941826_ChIP-Seq_K562_Human0.88749935
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88023861
154* P300_27268052_Chip-Seq_Bcells_Human0.87435633
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86848608
156FOXA2_19822575_ChIP-Seq_HepG2_Human0.86681881
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86583194
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86342313
159* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86063948
160CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85006558
161* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84880709
162UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83673641
163TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81362607
164SMAD4_21799915_ChIP-Seq_A2780_Human0.81072797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology7.79411636
2MP0004782_abnormal_surfactant_physiolog7.07087026
3MP0001958_emphysema5.79908268
4MP0010368_abnormal_lymphatic_system5.38143665
5MP0001984_abnormal_olfaction5.09420346
6MP0002138_abnormal_hepatobiliary_system4.79877233
7MP0001879_abnormal_lymphatic_vessel4.57060455
8MP0005167_abnormal_blood-brain_barrier4.39482703
9MP0004043_abnormal_pH_regulation4.22824881
10MP0004133_heterotaxia4.02461038
11MP0008789_abnormal_olfactory_epithelium3.58850316
12MP0008995_early_reproductive_senescence3.27269513
13MP0003191_abnormal_cellular_cholesterol2.97554253
14MP0003724_increased_susceptibility_to2.87228491
15MP0005083_abnormal_biliary_tract2.76308733
16MP0000383_abnormal_hair_follicle2.69366078
17MP0000566_synostosis2.60801266
18MP0005377_hearing/vestibular/ear_phenot2.47742596
19MP0003878_abnormal_ear_physiology2.47742596
20MP0004272_abnormal_basement_membrane2.46928377
21MP0002133_abnormal_respiratory_system2.46425492
22MP0005388_respiratory_system_phenotype2.46425492
23MP0003656_abnormal_erythrocyte_physiolo2.45085014
24MP0010678_abnormal_skin_adnexa2.40794484
25MP0005394_taste/olfaction_phenotype2.33819635
26MP0005499_abnormal_olfactory_system2.33819635
27MP0004019_abnormal_vitamin_homeostasis2.01632007
28MP0002295_abnormal_pulmonary_circulatio2.01020985
29MP0003566_abnormal_cell_adhesion1.99547542
30MP0000678_abnormal_parathyroid_gland1.95560155
31MP0001177_atelectasis1.95359081
32MP0002160_abnormal_reproductive_system1.93208577
33MP0008004_abnormal_stomach_pH1.84495658
34MP0000767_abnormal_smooth_muscle1.82128710
35MP0000343_altered_response_to1.81305424
36MP0001346_abnormal_lacrimal_gland1.78379984
37MP0005164_abnormal_response_to1.72661826
38MP0000249_abnormal_blood_vessel1.67409217
39MP0004883_abnormal_blood_vessel1.61435103
40MP0000537_abnormal_urethra_morphology1.59408733
41MP0005395_other_phenotype1.58768524
42MP0000465_gastrointestinal_hemorrhage1.53086312
43MP0006138_congestive_heart_failure1.52288726
44MP0010234_abnormal_vibrissa_follicle1.50927815
45MP0003303_peritoneal_inflammation1.48425980
46MP0003705_abnormal_hypodermis_morpholog1.48239677
47MP0005595_abnormal_vascular_smooth1.48186516
48MP0002249_abnormal_larynx_morphology1.44559400
49MP0010155_abnormal_intestine_physiology1.42035956
50MP0005275_abnormal_skin_tensile1.37144392
51MP0001175_abnormal_lung_morphology1.36612886
52MP0003091_abnormal_cell_migration1.35827609
53MP0009379_abnormal_foot_pigmentation1.35758111
54MP0003950_abnormal_plasma_membrane1.34355101
55MP0003279_aneurysm1.31094420
56MP0002139_abnormal_hepatobiliary_system1.27425548
57* MP0001765_abnormal_ion_homeostasis1.27269957
58MP0003828_pulmonary_edema1.23588078
59MP0009764_decreased_sensitivity_to1.23464039
60MP0000534_abnormal_ureter_morphology1.22138347
61MP0002876_abnormal_thyroid_physiology1.15801442
62MP0008438_abnormal_cutaneous_collagen1.15621743
63MP0000681_abnormal_thyroid_gland1.12035416
64MP0003075_altered_response_to1.09421884
65MP0002233_abnormal_nose_morphology1.07968139
66MP0002734_abnormal_mechanical_nocicepti1.07126067
67MP0004264_abnormal_extraembryonic_tissu1.06802832
68MP0010030_abnormal_orbit_morphology1.06358381
69MP0004084_abnormal_cardiac_muscle1.05899395
70MP0001544_abnormal_cardiovascular_syste1.05445342
71MP0005385_cardiovascular_system_phenoty1.05445342
72MP0002128_abnormal_blood_circulation1.05034852
73MP0005166_decreased_susceptibility_to1.04773790
74* MP0002132_abnormal_respiratory_system1.04592125
75MP0002925_abnormal_cardiovascular_devel1.03930795
76MP0004510_myositis1.01296588
77MP0005058_abnormal_lysosome_morphology1.00578140
78MP0005365_abnormal_bile_salt0.99443062
79MP0003453_abnormal_keratinocyte_physiol0.96732716
80MP0005165_increased_susceptibility_to0.94493711
81MP0002638_abnormal_pupillary_reflex0.93760765
82MP0003115_abnormal_respiratory_system0.93726648
83MP0005408_hypopigmentation0.91965529
84MP0002168_other_aberrant_phenotype0.91842443
85MP0005023_abnormal_wound_healing0.89694307
86MP0005389_reproductive_system_phenotype0.89119638
87MP0006054_spinal_hemorrhage0.89100949
88MP0003300_gastrointestinal_ulcer0.88643489
89MP0001614_abnormal_blood_vessel0.87790337
90MP0002735_abnormal_chemical_nociception0.85888387
91MP0003448_altered_tumor_morphology0.85617934
92* MP0008875_abnormal_xenobiotic_pharmacok0.84893674
93MP0001756_abnormal_urination0.83757412
94MP0005623_abnormal_meninges_morphology0.83604534
95MP0001542_abnormal_bone_strength0.83156565
96MP0005220_abnormal_exocrine_pancreas0.81729946
97MP0002877_abnormal_melanocyte_morpholog0.80861281
98MP0000516_abnormal_urinary_system0.80781181
99MP0005367_renal/urinary_system_phenotyp0.80781181
100MP0009046_muscle_twitch0.79793256
101MP0004085_abnormal_heartbeat0.79740032
102MP0001851_eye_inflammation0.79039841
103MP0006082_CNS_inflammation0.78879217
104* MP0005636_abnormal_mineral_homeostasis0.78072276
105MP0001545_abnormal_hematopoietic_system0.77756247
106MP0005397_hematopoietic_system_phenotyp0.77756247
107MP0001929_abnormal_gametogenesis0.75833748
108MP0005409_darkened_coat_color0.75531575
109MP0009703_decreased_birth_body0.73864682
110MP0002796_impaired_skin_barrier0.73817076
111MP0001485_abnormal_pinna_reflex0.72830758
112MP0001293_anophthalmia0.72225202
113MP0003638_abnormal_response/metabolism_0.72031991
114MP0009763_increased_sensitivity_to0.71598714
115MP0008961_abnormal_basal_metabolism0.71283007
116MP0003698_abnormal_male_reproductive0.70999400
117MP0002332_abnormal_exercise_endurance0.70454752
118MP0002909_abnormal_adrenal_gland0.69453191
119MP0001790_abnormal_immune_system0.69423532
120MP0005387_immune_system_phenotype0.69423532
121MP0004885_abnormal_endolymph0.69033509
122MP0001270_distended_abdomen0.68226908
123MP0005503_abnormal_tendon_morphology0.68004340
124MP0009780_abnormal_chondrocyte_physiolo0.67775895
125MP0009765_abnormal_xenobiotic_induced0.67110609
126MP0009384_cardiac_valve_regurgitation0.66167229
127MP0001943_abnormal_respiration0.65277250
128MP0005310_abnormal_salivary_gland0.64535645
129MP0002282_abnormal_trachea_morphology0.64501944
130MP0010329_abnormal_lipoprotein_level0.64392861
131MP0003866_abnormal_defecation0.64141880
132MP0000467_abnormal_esophagus_morphology0.62683515
133* MP0009643_abnormal_urine_homeostasis0.60621900
134MP0002405_respiratory_system_inflammati0.60526099
135MP0005464_abnormal_platelet_physiology0.59011249
136MP0000858_altered_metastatic_potential0.58244360
137MP0002116_abnormal_craniofacial_bone0.57744160
138MP0002896_abnormal_bone_mineralization0.57730868
139* MP0002136_abnormal_kidney_physiology0.57689481
140MP0000230_abnormal_systemic_arterial0.57436225
141MP0001324_abnormal_eye_pigmentation0.57116261
142MP0004036_abnormal_muscle_relaxation0.56779593
143MP0003045_fibrosis0.56541313
144MP0010352_gastrointestinal_tract_polyps0.53117851
145MP0001299_abnormal_eye_distance/0.52589085
146MP0002118_abnormal_lipid_homeostasis0.52286029
147MP0000026_abnormal_inner_ear0.51999675
148MP0002084_abnormal_developmental_patter0.51683827
149* MP0002135_abnormal_kidney_morphology0.51612950
150MP0004484_altered_response_of0.51603503
151MP0001664_abnormal_digestion0.51402206
152MP0002098_abnormal_vibrissa_morphology0.51251433
153MP0001784_abnormal_fluid_regulation0.50836603
154MP0001849_ear_inflammation0.50550469
155MP0005085_abnormal_gallbladder_physiolo0.50287969
156MP0001502_abnormal_circadian_rhythm0.50228239
157MP0000462_abnormal_digestive_system0.49748532
158MP0002166_altered_tumor_susceptibility0.49361676
159MP0000685_abnormal_immune_system0.49289300
160MP0005248_abnormal_Harderian_gland0.48492180
161MP0002229_neurodegeneration0.46151795
162MP0001663_abnormal_digestive_system0.45626722
163MP0008873_increased_physiological_sensi0.43943124
164MP0001666_abnormal_nutrient_absorption0.43655134
165* MP0002277_abnormal_respiratory_mucosa0.43124295
166MP0005253_abnormal_eye_physiology0.41937551

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)9.27831847
2Hyperactive renin-angiotensin system (HP:0000841)8.56857069
3Chronic bronchitis (HP:0004469)7.91808060
4Polycythemia (HP:0001901)7.61059085
5Hematochezia (HP:0002573)6.31825201
6Abnormality of the nasal mucosa (HP:0000433)6.17120470
7Spontaneous hematomas (HP:0007420)5.91042282
8Renal salt wasting (HP:0000127)5.67858606
9Hyperkalemia (HP:0002153)5.19460277
10Recurrent sinusitis (HP:0011108)4.58084577
11Infertility (HP:0000789)4.21170206
12Hyperaldosteronism (HP:0000859)4.15505118
13Esophageal varix (HP:0002040)4.10186452
14Tubulointerstitial fibrosis (HP:0005576)4.08348280
15Bronchitis (HP:0012387)4.07453918
16Recurrent otitis media (HP:0000403)4.02327770
17Conjunctival telangiectasia (HP:0000524)4.01351486
18Male infertility (HP:0003251)4.00184913
19Tachypnea (HP:0002789)3.88490991
20Visceral angiomatosis (HP:0100761)3.82182217
21Cerebral hemorrhage (HP:0001342)3.81534277
22Single umbilical artery (HP:0001195)3.73497211
23Abnormality of the fetal cardiovascular system (HP:0010948)3.73497211
24Abnormal umbilical cord blood vessels (HP:0011403)3.73497211
25Abnormality of renin-angiotensin system (HP:0000847)3.65902483
26Decreased circulating renin level (HP:0003351)3.62626297
27Potter facies (HP:0002009)3.60272569
28Facial shape deformation (HP:0011334)3.60272569
29Occipital encephalocele (HP:0002085)3.57073383
30Hemangiomatosis (HP:0007461)3.51817395
31Abnormality of the vasculature of the conjunctiva (HP:0008054)3.48333291
32Hypotension (HP:0002615)3.47926479
33Respiratory distress (HP:0002098)3.40661452
34Pancreatic fibrosis (HP:0100732)3.35287271
35Deep venous thrombosis (HP:0002625)3.34130646
36Long toe (HP:0010511)3.33108578
37Abnormality of chloride homeostasis (HP:0011422)3.30137205
38True hermaphroditism (HP:0010459)3.26247915
39Pulmonary artery stenosis (HP:0004415)3.23178938
40Growth hormone excess (HP:0000845)3.19589145
41Intestinal atresia (HP:0011100)3.05343025
42Atelectasis (HP:0100750)3.03891285
43Hyponatremia (HP:0002902)3.00123322
44Annular pancreas (HP:0001734)2.98412158
45Pulmonary hypertension (HP:0002092)2.96839155
46Shawl scrotum (HP:0000049)2.84556871
47Cystic liver disease (HP:0006706)2.76359573
48Gout (HP:0001997)2.75146055
49Hypokalemic alkalosis (HP:0001949)2.72191293
50Molar tooth sign on MRI (HP:0002419)2.69740717
51Abnormality of midbrain morphology (HP:0002418)2.69740717
52Pancreatic cysts (HP:0001737)2.65178735
53Neurofibrillary tangles (HP:0002185)2.64623554
54Bronchiectasis (HP:0002110)2.63186411
55Onycholysis (HP:0001806)2.60825764
56Nephronophthisis (HP:0000090)2.57896296
57Camptodactyly of toe (HP:0001836)2.57553073
58Abnormality of the pulmonary veins (HP:0011718)2.56866903
59Hydroureter (HP:0000072)2.56179341
60Cavernous hemangioma (HP:0001048)2.50487190
61Nasal polyposis (HP:0100582)2.48252081
62Abnormality of sodium homeostasis (HP:0010931)2.46513547
63Mucosal telangiectasiae (HP:0100579)2.46373581
64Adrenal overactivity (HP:0002717)2.45306521
65Cerebral aneurysm (HP:0004944)2.40788226
66Recurrent gram-negative bacterial infections (HP:0005420)2.39661056
67Microcytic anemia (HP:0001935)2.39608955
68Postaxial foot polydactyly (HP:0001830)2.38497799
69Ulnar bowing (HP:0003031)2.37840472
70Chronic hepatic failure (HP:0100626)2.37301762
71Eczematoid dermatitis (HP:0000976)2.31704687
72Broad metatarsal (HP:0001783)2.30039985
73Complement deficiency (HP:0004431)2.23523022
74Hypoplastic left heart (HP:0004383)2.22983103
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.21681810
76Osteolytic defects of the hand bones (HP:0009699)2.21681810
77Tubulointerstitial abnormality (HP:0001969)2.21156163
78Abnormality of the umbilical cord (HP:0010881)2.18209180
79Recurrent bronchitis (HP:0002837)2.16279944
80Chronic sinusitis (HP:0011109)2.13625354
81Portal hypertension (HP:0001409)2.10610879
82Bronchomalacia (HP:0002780)2.09817446
83Cerebral inclusion bodies (HP:0100314)2.09705548
84Midline defect of the nose (HP:0004122)2.08445097
85Bell-shaped thorax (HP:0001591)2.05318700
86Seborrheic dermatitis (HP:0001051)2.01709997
87Cerebral palsy (HP:0100021)2.01614419
88Chronic otitis media (HP:0000389)2.01276890
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6941404
90Abnormal respiratory epithelium morphology (HP:0012253)11.4387256
91Abnormal respiratory motile cilium morphology (HP:0005938)11.4387256
92Abnormal respiratory motile cilium physiology (HP:0012261)11.1882655
93Absent/shortened dynein arms (HP:0200106)11.0302923
94Dynein arm defect of respiratory motile cilia (HP:0012255)11.0302923
95Abnormal ciliary motility (HP:0012262)11.0175324
96Rhinitis (HP:0012384)10.2620271
97Absent frontal sinuses (HP:0002688)1.99918637
98Congenital hepatic fibrosis (HP:0002612)1.97260293
99Abnormality of the renal medulla (HP:0100957)1.95928019
100Abnormality of the gastric mucosa (HP:0004295)1.93194752
101Anencephaly (HP:0002323)1.91278164
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.87494701
103Flexion contracture of toe (HP:0005830)1.87004812
104Joint contractures involving the joints of the feet (HP:0100492)1.87004812
105Rapidly progressive (HP:0003678)1.86898860
106Abnormality of the hepatic vasculature (HP:0006707)1.84769195
107Disproportionate tall stature (HP:0001519)1.83119044
108Aortic valve stenosis (HP:0001650)1.81374690
109Rectal prolapse (HP:0002035)1.81310196
110Tubulointerstitial nephritis (HP:0001970)1.78274583
111Male pseudohermaphroditism (HP:0000037)1.77761344
112Redundant skin (HP:0001582)1.72660517
113Asplenia (HP:0001746)1.72373646
114Neonatal death (HP:0003811)1.71627589
115Aortic aneurysm (HP:0004942)1.71276338
116Pulmonary embolism (HP:0002204)1.70507810
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.68851036
118Abnormality of potassium homeostasis (HP:0011042)1.68760545
119Medial flaring of the eyebrow (HP:0010747)1.68164278
120Vascular calcification (HP:0004934)1.65456481
121Supranuclear gaze palsy (HP:0000605)1.65351243
122Bowing of the arm (HP:0006488)1.64703892
123Bowed forearm bones (HP:0003956)1.64703892
124Fragile nails (HP:0001808)1.63704866
125Cerebral ischemia (HP:0002637)1.62354990
126Nephropathy (HP:0000112)1.62155902
127Oculomotor apraxia (HP:0000657)1.61871218
128Right ventricular cardiomyopathy (HP:0011663)1.61318230
129Vascular tortuosity (HP:0004948)1.61062094
130Abnormal hemoglobin (HP:0011902)1.61041971
131Stroke (HP:0001297)1.60070883
132Furrowed tongue (HP:0000221)1.59907825
133Cardiovascular calcification (HP:0011915)1.59381339
134Nephritis (HP:0000123)1.59291324
135Congenital primary aphakia (HP:0007707)1.58884669
136Loss of speech (HP:0002371)1.58830614
137Tubular atrophy (HP:0000092)1.57254059
138Gait imbalance (HP:0002141)1.55732116
139Shallow orbits (HP:0000586)1.55489685
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.54786443
141Sclerocornea (HP:0000647)1.54756084
142Postaxial hand polydactyly (HP:0001162)1.47153170
143Nephrogenic diabetes insipidus (HP:0009806)1.37016957
144Glucose intolerance (HP:0000833)1.29973863
145Short thorax (HP:0010306)1.26836070
146Absent rod-and cone-mediated responses on ERG (HP:0007688)1.25834830
147Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.23777899
148Median cleft lip (HP:0000161)1.23604927
149Abnormality of the frontal sinuses (HP:0002687)1.23173085
150Hand muscle atrophy (HP:0009130)1.23084605
151Preaxial hand polydactyly (HP:0001177)1.20638387
152Abnormality of the distal phalanges of the toes (HP:0010182)1.20240099
153Abnormality of the dental root (HP:0006486)1.14868602
154Taurodontia (HP:0000679)1.14868602
155Abnormality of permanent molar morphology (HP:0011071)1.14868602
156Cone-rod dystrophy (HP:0000548)1.13601815
157Bifid scrotum (HP:0000048)1.11744330
158Obstructive sleep apnea (HP:0002870)1.10640526
159Short nail (HP:0001799)1.10392852
160Poor coordination (HP:0002370)1.08290917
161Decreased central vision (HP:0007663)1.08276409
162Stage 5 chronic kidney disease (HP:0003774)1.07237425
163Fetal akinesia sequence (HP:0001989)1.06889961
164Abnormality of monocarboxylic acid metabolism (HP:0010996)1.06814103
165Abnormality of molar morphology (HP:0011070)1.05565858
166Abnormality of molar (HP:0011077)1.05565858
167Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.04460113
168Vaginal atresia (HP:0000148)1.04023884
169Genital tract atresia (HP:0001827)1.03444265
170Abnormality of the dental pulp (HP:0006479)1.01587847
171Muscle fiber splitting (HP:0003555)1.00368715
172Short femoral neck (HP:0100864)0.99689134
173Self-mutilation (HP:0000742)0.99521377
174Lip pit (HP:0100267)0.98946052
175Aplasia of the musculature (HP:0100854)0.98102435
176Flat acetabular roof (HP:0003180)0.97834576
177Spinal muscular atrophy (HP:0007269)0.94666315
178Popliteal pterygium (HP:0009756)0.94624388
179Abnormality of dentin (HP:0010299)0.91999921
180Supernumerary spleens (HP:0009799)0.89833384
181Abnormal drinking behavior (HP:0030082)0.89069472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.33110276
2TGFBR25.36558164
3EPHB23.36453719
4DAPK22.99759177
5LRRK22.66628753
6GRK12.52076867
7NME12.35214605
8EPHB12.32451236
9SMG12.27502769
10TRIB32.27252358
11PAK42.26829854
12MAPKAPK32.25898724
13ERN12.12110028
14EEF2K2.08220060
15FGFR22.04503624
16TTK2.03912852
17STK102.01852084
18FGFR41.95626000
19TGFBR11.94561571
20MYLK1.90044051
21FER1.72010192
22KDR1.68912932
23RIPK11.66629827
24ZAP701.66626331
25PDGFRA1.43326987
26PTK61.41338048
27MAP3K21.40134437
28MST41.39898032
29ILK1.34845664
30MAP2K31.33505149
31RIPK41.27850675
32CSK1.24713913
33STK241.24208776
34PDGFRB1.22449124
35MAP3K121.20465095
36NEK61.19227792
37KSR21.16801818
38MAP3K31.07720430
39TRPM71.05259655
40GRK51.04309431
41PTK21.02052812
42TESK11.01355339
43TEC1.00970955
44PRKD10.98431853
45PNCK0.98349427
46FGFR30.93708206
47PTK2B0.91976648
48EPHA30.87135235
49ICK0.84934423
50PRKCI0.84383181
51PRKCH0.83031049
52TLK10.82509706
53MAPK150.81174468
54EGFR0.79072547
55CAMKK10.78396453
56PDPK10.77382368
57DAPK30.71965600
58MAP3K10.69453144
59GRK70.68013139
60DDR20.66826867
61GSK3A0.65363237
62ERBB20.64320810
63MATK0.62895843
64LIMK10.62360356
65DAPK10.62281259
66MAP3K110.61850917
67BRSK20.61397300
68STK380.60669999
69ITK0.59641441
70MET0.59154690
71ERBB30.58155442
72TTN0.56843925
73LMTK20.56160858
74AKT30.55823418
75MAP2K20.55539118
76PKN20.54815613
77MOS0.51833544
78MAP4K10.51727030
79NTRK10.49989319
80TBK10.48713681
81CAMK2G0.47574760
82PRKG20.47386896
83ROCK20.46836067
84RET0.46741092
85DMPK0.45982018
86MST1R0.44598527
87PRKCD0.44295406
88DYRK1B0.44098670
89CDK60.43900496
90NLK0.43759076
91KIT0.43284466
92SRC0.43040265
93MARK20.42501851
94AURKA0.42128276
95CDC42BPA0.41823257
96RPS6KB20.41737441
97EPHA20.41545700
98MAP2K10.39855398
99SGK10.39850645
100NEK90.39707386
101JAK10.39539560
102IRAK10.39259456
103JAK20.37937992
104PRKD20.37789940
105CAMK1D0.37514706
106TYK20.36939709
107GRK60.36525281
108PRKAA20.36308866
109PRKD30.35584565
110TYRO30.35492728
111TAOK10.35191764
112ROCK10.35119205
113FES0.34764141
114PRKCE0.34201599
115LATS10.30903192
116STK160.30154817
117IGF1R0.30151051
118TAOK30.28381076
119FYN0.27876822
120MAP3K70.27852131
121IKBKE0.27388163
122MAP3K40.26784426
123HIPK20.25987962
124ADRBK10.25751055
125ABL10.25518984
126MAPKAPK50.25068784
127BCR0.24661507
128AKT20.24056706
129FGR0.23899387
130CAMK1G0.23022385
131MAP2K40.22681633
132CAMK40.22536456
133PRKCZ0.22178751
134PRKCQ0.22086888
135STK38L0.20568263
136PLK10.20199559
137PASK0.19521160
138PRKCA0.16998072
139PRKACA0.16717137
140TSSK60.16581937
141CHEK20.16178943
142PAK10.15054352
143CAMKK20.14450034
144RPS6KA20.13917407
145MAP3K80.13830580
146DYRK1A0.13819340
147PRKDC0.12613353
148PDK10.11211953
149YES10.08655625
150MAP2K70.08124271

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.03957517
2Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.79395721
3Tyrosine metabolism_Homo sapiens_hsa003503.65632182
4beta-Alanine metabolism_Homo sapiens_hsa004102.98336610
5Huntingtons disease_Homo sapiens_hsa050162.94062409
6Leukocyte transendothelial migration_Homo sapiens_hsa046702.40061894
7ECM-receptor interaction_Homo sapiens_hsa045122.39857529
8Caffeine metabolism_Homo sapiens_hsa002322.24215571
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17146928
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.16715172
11Linoleic acid metabolism_Homo sapiens_hsa005911.97431229
12Adherens junction_Homo sapiens_hsa045201.91356156
13Sphingolipid metabolism_Homo sapiens_hsa006001.90055029
14Bladder cancer_Homo sapiens_hsa052191.89873065
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85712189
16Tight junction_Homo sapiens_hsa045301.82442638
17Focal adhesion_Homo sapiens_hsa045101.82279571
18Complement and coagulation cascades_Homo sapiens_hsa046101.80674713
19Tryptophan metabolism_Homo sapiens_hsa003801.77708140
20Renin-angiotensin system_Homo sapiens_hsa046141.63090769
21Renin secretion_Homo sapiens_hsa049241.62944035
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.60374779
23Pertussis_Homo sapiens_hsa051331.58244737
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54779861
25Phagosome_Homo sapiens_hsa041451.52727829
26ABC transporters_Homo sapiens_hsa020101.46944856
27Lysosome_Homo sapiens_hsa041421.44963803
28Selenocompound metabolism_Homo sapiens_hsa004501.43473666
29Renal cell carcinoma_Homo sapiens_hsa052111.41001715
30Taste transduction_Homo sapiens_hsa047421.39802956
31Histidine metabolism_Homo sapiens_hsa003401.39682915
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38751053
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36123622
34Platelet activation_Homo sapiens_hsa046111.36031539
35Rap1 signaling pathway_Homo sapiens_hsa040151.29653884
36Mineral absorption_Homo sapiens_hsa049781.26306990
37VEGF signaling pathway_Homo sapiens_hsa043701.24528611
38Amoebiasis_Homo sapiens_hsa051461.23710251
39Axon guidance_Homo sapiens_hsa043601.23489299
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21015917
41Chemical carcinogenesis_Homo sapiens_hsa052041.20932577
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19304566
43Starch and sucrose metabolism_Homo sapiens_hsa005001.16810020
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.14438995
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11409621
46TGF-beta signaling pathway_Homo sapiens_hsa043501.08537069
47Peroxisome_Homo sapiens_hsa041461.08145952
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07894499
49Small cell lung cancer_Homo sapiens_hsa052221.06638428
50Dorso-ventral axis formation_Homo sapiens_hsa043201.06436663
51Endocytosis_Homo sapiens_hsa041441.04857316
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.04172599
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01995500
54Proteoglycans in cancer_Homo sapiens_hsa052051.01046188
55Retinol metabolism_Homo sapiens_hsa008301.00416525
56Hippo signaling pathway_Homo sapiens_hsa043900.97716730
57Malaria_Homo sapiens_hsa051440.97540999
58Circadian rhythm_Homo sapiens_hsa047100.96467201
59Arachidonic acid metabolism_Homo sapiens_hsa005900.96375819
60Pancreatic cancer_Homo sapiens_hsa052120.96330500
61Prion diseases_Homo sapiens_hsa050200.95676534
62Salivary secretion_Homo sapiens_hsa049700.91862322
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90933064
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90675334
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88115467
66Toxoplasmosis_Homo sapiens_hsa051450.87885632
67Salmonella infection_Homo sapiens_hsa051320.87555386
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85046133
69Choline metabolism in cancer_Homo sapiens_hsa052310.83256981
70Dilated cardiomyopathy_Homo sapiens_hsa054140.83170037
71Staphylococcus aureus infection_Homo sapiens_hsa051500.81147316
72Rheumatoid arthritis_Homo sapiens_hsa053230.80589426
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.80336924
74Vibrio cholerae infection_Homo sapiens_hsa051100.79645209
75Viral myocarditis_Homo sapiens_hsa054160.79502975
76Bile secretion_Homo sapiens_hsa049760.78809690
77Pathways in cancer_Homo sapiens_hsa052000.76512268
78Hepatitis C_Homo sapiens_hsa051600.74727692
79Shigellosis_Homo sapiens_hsa051310.74370993
80Ovarian steroidogenesis_Homo sapiens_hsa049130.72134153
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70603076
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.70402146
83Hematopoietic cell lineage_Homo sapiens_hsa046400.69943519
84Gap junction_Homo sapiens_hsa045400.66683287
85Gastric acid secretion_Homo sapiens_hsa049710.65820575
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65206461
87Notch signaling pathway_Homo sapiens_hsa043300.63941111
88Fatty acid degradation_Homo sapiens_hsa000710.63321236
89Fatty acid elongation_Homo sapiens_hsa000620.60619652
90Thyroid hormone synthesis_Homo sapiens_hsa049180.59347953
91Thyroid cancer_Homo sapiens_hsa052160.59007658
92Chronic myeloid leukemia_Homo sapiens_hsa052200.58544218
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58127254
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.57880124
95Olfactory transduction_Homo sapiens_hsa047400.57072589
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.56819926
97Hedgehog signaling pathway_Homo sapiens_hsa043400.54914655
98Fatty acid biosynthesis_Homo sapiens_hsa000610.54125193
99Protein digestion and absorption_Homo sapiens_hsa049740.54051045
100Glutathione metabolism_Homo sapiens_hsa004800.53940665
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.53267627
102Chemokine signaling pathway_Homo sapiens_hsa040620.52709414
103Ras signaling pathway_Homo sapiens_hsa040140.51754565
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50154786
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49774002
106Endometrial cancer_Homo sapiens_hsa052130.48090767
107Leishmaniasis_Homo sapiens_hsa051400.47696763
108Tuberculosis_Homo sapiens_hsa051520.47529320
109Acute myeloid leukemia_Homo sapiens_hsa052210.46949033
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45836671
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45060582
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44549541
113Melanoma_Homo sapiens_hsa052180.44016368
114Nitrogen metabolism_Homo sapiens_hsa009100.43639981
115Apoptosis_Homo sapiens_hsa042100.43316338
116Basal cell carcinoma_Homo sapiens_hsa052170.42934731
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41879734
118Estrogen signaling pathway_Homo sapiens_hsa049150.41676814
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40098605
120Type I diabetes mellitus_Homo sapiens_hsa049400.38553813
121PPAR signaling pathway_Homo sapiens_hsa033200.38512133
122Osteoclast differentiation_Homo sapiens_hsa043800.38495802
123MicroRNAs in cancer_Homo sapiens_hsa052060.38306390
124cAMP signaling pathway_Homo sapiens_hsa040240.38123587
125TNF signaling pathway_Homo sapiens_hsa046680.38003113
126Vitamin digestion and absorption_Homo sapiens_hsa049770.36270582
127Glioma_Homo sapiens_hsa052140.36067942
128Collecting duct acid secretion_Homo sapiens_hsa049660.35182396
129Allograft rejection_Homo sapiens_hsa053300.34803311
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34486561
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.33079043
132Autoimmune thyroid disease_Homo sapiens_hsa053200.31632107
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29391402
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28509406
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28400066
136Cocaine addiction_Homo sapiens_hsa050300.28156339
137Insulin resistance_Homo sapiens_hsa049310.26877643
138Graft-versus-host disease_Homo sapiens_hsa053320.26681920
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.26491366
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25772059
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.25613730
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.25183753
143Asthma_Homo sapiens_hsa053100.24542767
144Serotonergic synapse_Homo sapiens_hsa047260.21450172
145Pancreatic secretion_Homo sapiens_hsa049720.20876265
146Antigen processing and presentation_Homo sapiens_hsa046120.20470923
147Metabolic pathways_Homo sapiens_hsa011000.19821202
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.18723967
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18044520
150Arginine and proline metabolism_Homo sapiens_hsa003300.17199290
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15286820
152Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14411202
153Calcium signaling pathway_Homo sapiens_hsa040200.14303497
154Amphetamine addiction_Homo sapiens_hsa050310.13604689
155Nicotine addiction_Homo sapiens_hsa050330.11374128
156Prostate cancer_Homo sapiens_hsa052150.10566410
157Phototransduction_Homo sapiens_hsa047440.10496177
158Glycerolipid metabolism_Homo sapiens_hsa005610.09914121
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.09798391
160Melanogenesis_Homo sapiens_hsa049160.09063610
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.06328387

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