SCGB1C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.75238690
2thrombin receptor signaling pathway (GO:0070493)7.64993520
3neutrophil activation involved in immune response (GO:0002283)7.29887814
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.63615172
5blood coagulation, intrinsic pathway (GO:0007597)6.13200965
6regulation of platelet aggregation (GO:0090330)6.13131666
7regulation of platelet activation (GO:0010543)5.92536590
8adenosine receptor signaling pathway (GO:0001973)5.82615303
9negative regulation of thymocyte apoptotic process (GO:0070244)5.64433345
10regulation of integrin-mediated signaling pathway (GO:2001044)5.46189896
11platelet aggregation (GO:0070527)5.42896293
12leukocyte migration involved in inflammatory response (GO:0002523)5.40061119
13negative regulation of homotypic cell-cell adhesion (GO:0034111)5.37043282
14negative regulation of norepinephrine secretion (GO:0010700)5.35389130
15negative regulation of platelet activation (GO:0010544)5.30312132
16low-density lipoprotein particle remodeling (GO:0034374)5.27153885
17negative regulation of heart rate (GO:0010459)5.26183608
18negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.06240752
19positive regulation of endothelial cell differentiation (GO:0045603)5.03982543
20lipoxygenase pathway (GO:0019372)5.02513632
21fusion of sperm to egg plasma membrane (GO:0007342)4.34885314
22negative regulation of protein localization to cell surface (GO:2000009)4.31653174
23platelet degranulation (GO:0002576)4.31631220
24neutrophil activation (GO:0042119)4.29764578
25beta-amyloid metabolic process (GO:0050435)4.24821617
26positive regulation of mast cell activation (GO:0033005)4.23454328
27G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.22668865
28negative regulation of response to food (GO:0032096)4.20502027
29negative regulation of appetite (GO:0032099)4.20502027
30regulation of Golgi to plasma membrane protein transport (GO:0042996)4.17521166
31purinergic nucleotide receptor signaling pathway (GO:0035590)4.13751991
32positive regulation of cAMP-mediated signaling (GO:0043950)4.12891637
33angiogenesis involved in wound healing (GO:0060055)4.11895812
34positive regulation of Rho protein signal transduction (GO:0035025)4.03659831
35regulation of integrin activation (GO:0033623)3.98111655
36polyamine biosynthetic process (GO:0006596)3.97892957
37positive regulation of macrophage differentiation (GO:0045651)3.91838788
38positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.91678917
39negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.90563302
40high-density lipoprotein particle remodeling (GO:0034375)3.87850230
41regulation of lipoprotein metabolic process (GO:0050746)3.85063253
42platelet activation (GO:0030168)3.84198059
43positive regulation of receptor recycling (GO:0001921)3.84041701
44positive regulation of systemic arterial blood pressure (GO:0003084)3.82472615
45phospholipid homeostasis (GO:0055091)3.81912071
46platelet formation (GO:0030220)3.79736790
47extracellular fibril organization (GO:0043206)3.79577627
48regulation of macrophage derived foam cell differentiation (GO:0010743)3.79443778
49granulocyte activation (GO:0036230)3.75476081
50regulation of homotypic cell-cell adhesion (GO:0034110)3.73767066
51homotypic cell-cell adhesion (GO:0034109)3.73504861
52negative regulation of heart contraction (GO:0045822)3.69439640
53regulation of norepinephrine secretion (GO:0014061)3.68756066
54reverse cholesterol transport (GO:0043691)3.68249248
55long-chain fatty acid biosynthetic process (GO:0042759)3.64877940
56purinergic receptor signaling pathway (GO:0035587)3.64672655
57regulation of cholesterol efflux (GO:0010874)3.62408362
58megakaryocyte development (GO:0035855)3.59998786
59negative regulation of neural precursor cell proliferation (GO:2000178)3.52665140
60negative regulation of T cell apoptotic process (GO:0070233)3.49300469
61regulation of MHC class II biosynthetic process (GO:0045346)3.45797055
62G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.45706033
63mitochondrial calcium ion transport (GO:0006851)3.41939990
64positive regulation of hemostasis (GO:1900048)3.39469971
65positive regulation of blood coagulation (GO:0030194)3.39469971
66regulation of endothelial cell differentiation (GO:0045601)3.39053836
67negative regulation of catecholamine secretion (GO:0033604)3.34747223
68termination of G-protein coupled receptor signaling pathway (GO:0038032)3.28211848
69negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25593523
70termination of signal transduction (GO:0023021)3.24349550
71vesicle targeting (GO:0006903)3.21403412
72autophagic vacuole fusion (GO:0000046)3.20066280
73plasma membrane fusion (GO:0045026)3.16128125
74regulation of receptor recycling (GO:0001919)3.15397124
75fibril organization (GO:0097435)3.13535586
76regulation of female receptivity (GO:0045924)3.04616467
77sequestering of actin monomers (GO:0042989)3.01553493
78positive regulation of coagulation (GO:0050820)3.00648894
79L-phenylalanine catabolic process (GO:0006559)2.99638884
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.99638884
81cyclooxygenase pathway (GO:0019371)2.99414212
82regulation of blood coagulation (GO:0030193)2.95467781
83regulation of hemostasis (GO:1900046)2.95467781
84relaxation of smooth muscle (GO:0044557)2.94226673
85pyrimidine nucleoside catabolic process (GO:0046135)2.94147529
86negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.93512270
87leukocyte degranulation (GO:0043299)2.93003706
88negative regulation of calcium ion transport into cytosol (GO:0010523)2.91967763
89dopamine transport (GO:0015872)2.90134988
90negative regulation of protein localization to plasma membrane (GO:1903077)2.90084255
91Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90022781
92cellular biogenic amine biosynthetic process (GO:0042401)2.89612562
93negative regulation of calcium ion transmembrane transport (GO:1903170)2.87845563
94negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87845563
95endothelium development (GO:0003158)2.85292084
96monoamine transport (GO:0015844)2.84542585
97negative regulation of T-helper cell differentiation (GO:0045623)2.83292698
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83292698
99tyrosine metabolic process (GO:0006570)2.83213962
100phagocytosis, engulfment (GO:0006911)2.82997570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human5.19400935
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.56532513
3SCL_19346495_ChIP-Seq_HPC-7_Human3.89950123
4RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.29772687
5GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.22369174
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08390770
7GATA1_19941826_ChIP-Seq_K562_Human3.04666719
8EZH2_22144423_ChIP-Seq_EOC_Human3.03719955
9LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.88485990
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.79417899
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72181479
12GATA2_19941826_ChIP-Seq_K562_Human2.66129785
13GATA1_19941827_ChIP-Seq_MEL_Mouse2.56383202
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40408958
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.30982334
16GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.25566214
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20984975
18TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.18671672
19GBX2_23144817_ChIP-Seq_PC3_Human2.17195973
20SPI1_23127762_ChIP-Seq_K562_Human2.16406674
21HTT_18923047_ChIP-ChIP_STHdh_Human2.15306288
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14646883
23ELK4_26923725_Chip-Seq_MESODERM_Mouse2.13506521
24GATA1_22383799_ChIP-Seq_G1ME_Mouse2.13386285
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.11516739
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06278053
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05079260
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03758370
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95360850
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85710282
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.77833068
32GATA1_22025678_ChIP-Seq_K562_Human1.69887196
33GATA1_19941827_ChIP-Seq_MEL86_Mouse1.58640980
34TAF15_26573619_Chip-Seq_HEK293_Human1.58100120
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55817101
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48990992
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46128539
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43459070
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42042238
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.41918372
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40512609
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39627199
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37148751
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37148751
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33038289
46KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25346151
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20205352
48SALL4_22934838_ChIP-ChIP_CD34+_Human1.20190265
49SPI1_20517297_ChIP-Seq_HL60_Human1.19138044
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18791644
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16586013
52RUNX_20019798_ChIP-Seq_JUKART_Human1.13354880
53ETS1_22383799_ChIP-Seq_G1ME_Mouse1.10665158
54NCOR1_26117541_ChIP-Seq_K562_Human1.03348008
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01340286
56LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01018819
57STAT1_20625510_ChIP-Seq_HELA_Human1.00653382
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99293734
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99283033
60EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97772583
61VDR_22108803_ChIP-Seq_LS180_Human0.95247277
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92437460
63GATA3_21878914_ChIP-Seq_MCF-7_Human0.91730881
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90194703
65OCT1_27270436_Chip-Seq_PROSTATE_Human0.88949332
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88801711
67GATA4_25053715_ChIP-Seq_YYC3_Human0.86891567
68SOX2_20726797_ChIP-Seq_SW620_Human0.86512618
69TCF4_18268006_ChIP-ChIP_LS174T_Human0.86017308
70RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85617150
71STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85421525
72BCAT_22108803_ChIP-Seq_LS180_Human0.85272500
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84346125
74BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84212016
75AR_25329375_ChIP-Seq_VCAP_Human0.81604442
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81465526
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81183161
78FLI1_27457419_Chip-Seq_LIVER_Mouse0.81037618
79UTX_26944678_Chip-Seq_JUKART_Human0.79871161
80SMAD4_21799915_ChIP-Seq_A2780_Human0.79621049
81ESR1_20079471_ChIP-ChIP_T-47D_Human0.79482818
82ERG_20517297_ChIP-Seq_VCAP_Human0.78977938
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78844839
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.78656444
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78402240
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.77392331
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77052214
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76382245
89EWS_26573619_Chip-Seq_HEK293_Human0.76116376
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75976521
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75533844
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73805056
93P53_22387025_ChIP-Seq_ESCs_Mouse0.73647425
94GF1_26923725_Chip-Seq_HPCs_Mouse0.73373674
95NANOG_19829295_ChIP-Seq_ESCs_Human0.73103101
96SOX2_19829295_ChIP-Seq_ESCs_Human0.73103101
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73053444
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72717948
99RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72430370
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71575346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.31343159
2MP0003724_increased_susceptibility_to3.64044939
3MP0000465_gastrointestinal_hemorrhage3.36149162
4MP0000343_altered_response_to2.47946547
5MP0003566_abnormal_cell_adhesion2.42037597
6MP0002736_abnormal_nociception_after2.37380914
7MP0005083_abnormal_biliary_tract2.34969849
8MP0004510_myositis2.34789771
9MP0000230_abnormal_systemic_arterial2.31062666
10MP0003303_peritoneal_inflammation2.24697783
11MP0001879_abnormal_lymphatic_vessel2.10902715
12MP0001835_abnormal_antigen_presentation2.07801668
13MP0005410_abnormal_fertilization2.01626159
14MP0005464_abnormal_platelet_physiology10.5441441
15MP0004084_abnormal_cardiac_muscle1.92476730
16MP0003638_abnormal_response/metabolism_1.91083043
17MP0008872_abnormal_physiological_respon1.89072962
18MP0005167_abnormal_blood-brain_barrier1.85495819
19MP0005058_abnormal_lysosome_morphology1.83986237
20MP0005084_abnormal_gallbladder_morpholo1.79705452
21MP0003879_abnormal_hair_cell1.79471299
22MP0003828_pulmonary_edema1.72243652
23MP0005671_abnormal_response_to1.69094183
24MP0008775_abnormal_heart_ventricle1.69047031
25MP0005646_abnormal_pituitary_gland1.63815638
26MP0010155_abnormal_intestine_physiology1.63112656
27MP0004130_abnormal_muscle_cell1.55152501
28MP0002148_abnormal_hypersensitivity_rea1.52982230
29MP0001851_eye_inflammation1.52215997
30MP0001968_abnormal_touch/_nociception1.47758137
31MP0004036_abnormal_muscle_relaxation1.41581688
32MP0002733_abnormal_thermal_nociception1.38714343
33MP0001663_abnormal_digestive_system1.37809918
34MP0000249_abnormal_blood_vessel1.31079033
35MP0002132_abnormal_respiratory_system1.30607519
36MP0005397_hematopoietic_system_phenotyp1.28630317
37MP0001545_abnormal_hematopoietic_system1.28630317
38MP0002398_abnormal_bone_marrow1.28462328
39MP0005000_abnormal_immune_tolerance1.28312605
40MP0004947_skin_inflammation1.26769837
41MP0010329_abnormal_lipoprotein_level1.25862197
42MP0004215_abnormal_myocardial_fiber1.23447579
43MP0009763_increased_sensitivity_to1.19374112
44MP0009697_abnormal_copulation1.19342605
45MP0003136_yellow_coat_color1.14302898
46MP0008874_decreased_physiological_sensi1.09907304
47MP0009780_abnormal_chondrocyte_physiolo1.07016165
48MP0001533_abnormal_skeleton_physiology1.04871484
49MP0000858_altered_metastatic_potential1.03693576
50MP0003866_abnormal_defecation1.01648231
51MP0009642_abnormal_blood_homeostasis0.99227614
52MP0002723_abnormal_immune_serum0.97445557
53MP0001970_abnormal_pain_threshold0.96323662
54MP0006276_abnormal_autonomic_nervous0.96299016
55MP0009764_decreased_sensitivity_to0.95040241
56MP0005501_abnormal_skin_physiology0.92934457
57MP0009765_abnormal_xenobiotic_induced0.91658858
58MP0002429_abnormal_blood_cell0.91505543
59MP0000015_abnormal_ear_pigmentation0.90935652
60MP0001765_abnormal_ion_homeostasis0.90862517
61MP0003436_decreased_susceptibility_to0.89022450
62MP0000689_abnormal_spleen_morphology0.88902775
63MP0005381_digestive/alimentary_phenotyp0.88521261
64MP0003656_abnormal_erythrocyte_physiolo0.86352119
65MP0001800_abnormal_humoral_immune0.85769539
66MP0005165_increased_susceptibility_to0.85594863
67MP0002452_abnormal_antigen_presenting0.84888880
68MP0002972_abnormal_cardiac_muscle0.83453031
69MP0005666_abnormal_adipose_tissue0.82504757
70MP0006138_congestive_heart_failure0.80566625
71MP0006054_spinal_hemorrhage0.80065851
72MP0005409_darkened_coat_color0.79840704
73MP0003011_delayed_dark_adaptation0.79068396
74MP0002722_abnormal_immune_system0.78996565
75MP0002877_abnormal_melanocyte_morpholog0.78791873
76MP0001544_abnormal_cardiovascular_syste0.78171587
77MP0005385_cardiovascular_system_phenoty0.78171587
78MP0005023_abnormal_wound_healing0.77941847
79MP0002735_abnormal_chemical_nociception0.77423359
80MP0006036_abnormal_mitochondrial_physio0.77299685
81MP0001845_abnormal_inflammatory_respons0.76949713
82MP0004134_abnormal_chest_morphology0.76600283
83MP0001664_abnormal_digestion0.75823023
84MP0001756_abnormal_urination0.73361258
85MP0002420_abnormal_adaptive_immunity0.72940569
86MP0000358_abnormal_cell_content/0.72514268
87MP0002998_abnormal_bone_remodeling0.71733730
88MP0001819_abnormal_immune_cell0.71694627
89MP0000716_abnormal_immune_system0.70665798
90MP0002128_abnormal_blood_circulation0.69168765
91MP0000685_abnormal_immune_system0.67881413
92MP0005174_abnormal_tail_pigmentation0.67548890
93MP0002653_abnormal_ependyma_morphology0.67317575
94MP0009333_abnormal_splenocyte_physiolog0.67121367
95MP0002118_abnormal_lipid_homeostasis0.66900131
96MP0005535_abnormal_body_temperature0.66273223
97MP0005620_abnormal_muscle_contractility0.64918365
98MP0000383_abnormal_hair_follicle0.64262882
99MP0003075_altered_response_to0.64031159
100MP0003186_abnormal_redox_activity0.62188557

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.53669113
2Purpura (HP:0000979)9.12147168
3Epistaxis (HP:0000421)7.75069655
4Hyperlipoproteinemia (HP:0010980)7.30377547
5Gingival bleeding (HP:0000225)6.27560620
6Abnormal platelet function (HP:0011869)5.46818486
7Impaired platelet aggregation (HP:0003540)5.46818486
8Dyschromatopsia (HP:0007641)4.76891041
9Acanthocytosis (HP:0001927)4.32840773
10Poikilocytosis (HP:0004447)4.17806865
11Spontaneous hematomas (HP:0007420)3.93133188
12Conjunctival telangiectasia (HP:0000524)3.90915603
13Abnormal pupillary function (HP:0007686)3.67330463
14Paralysis (HP:0003470)3.43756283
15Abnormality of the common coagulation pathway (HP:0010990)3.41886313
16Abnormality of the vasculature of the conjunctiva (HP:0008054)3.37113063
17Bruising susceptibility (HP:0000978)3.31619095
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.22895160
19Abnormality of lateral ventricle (HP:0030047)3.13524094
20Xanthomatosis (HP:0000991)2.85449298
21Abnormal auditory evoked potentials (HP:0006958)2.77870605
22Decreased central vision (HP:0007663)2.76381809
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.70781028
24Increased density of long bones (HP:0006392)2.69901193
25Upper limb muscle weakness (HP:0003484)2.68786399
26Hepatosplenomegaly (HP:0001433)2.65418865
27Joint swelling (HP:0001386)2.58512893
28Male infertility (HP:0003251)2.50499155
29Generalized aminoaciduria (HP:0002909)2.49632185
30Increased IgM level (HP:0003496)2.45880586
31Joint hemorrhage (HP:0005261)2.36693197
32Stomatitis (HP:0010280)2.31436637
33Nausea (HP:0002018)2.30134030
34Papillary thyroid carcinoma (HP:0002895)2.25345708
35Tinnitus (HP:0000360)2.23474668
36Ventricular fibrillation (HP:0001663)2.22752921
37Abnormality of macrophages (HP:0004311)2.21564840
38Abnormality of iron homeostasis (HP:0011031)2.12925461
39Thyroid-stimulating hormone excess (HP:0002925)2.12080245
40Dysautonomia (HP:0002459)2.09423476
41Abnormal ciliary motility (HP:0012262)2.08955256
42Spontaneous abortion (HP:0005268)2.06563502
43Prolonged bleeding time (HP:0003010)11.8702643
44Menorrhagia (HP:0000132)11.1134229
45Increased mean platelet volume (HP:0011877)10.7978035
46Abnormal platelet volume (HP:0011876)10.1100187
47Hyperthyroidism (HP:0000836)1.98101417
48Hypophosphatemic rickets (HP:0004912)1.96446339
49Tongue fasciculations (HP:0001308)1.91553403
503-Methylglutaconic aciduria (HP:0003535)1.88607598
51Abnormality of transition element cation homeostasis (HP:0011030)1.88382773
52Biliary tract neoplasm (HP:0100574)1.86908844
53Distal lower limb amyotrophy (HP:0008944)1.86222417
54Myocardial infarction (HP:0001658)1.76295728
55Episodic fever (HP:0001954)1.74207835
56Muscle fibrillation (HP:0010546)1.73213611
57Abnormal respiratory epithelium morphology (HP:0012253)1.71958313
58Abnormal respiratory motile cilium morphology (HP:0005938)1.71958313
59Increased serum ferritin (HP:0003281)1.71141158
60Encephalitis (HP:0002383)1.69094483
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67467654
62Arterial thrombosis (HP:0004420)1.64359126
63Infertility (HP:0000789)1.64277093
64Polycythemia (HP:0001901)1.63173500
65Arthropathy (HP:0003040)1.62897501
66Chronic obstructive pulmonary disease (HP:0006510)1.60587980
67Obstructive lung disease (HP:0006536)1.60587980
68Renal Fanconi syndrome (HP:0001994)1.56580765
69Polyphagia (HP:0002591)1.56076444
70Abnormality of the prostate (HP:0008775)1.55682418
71Thyroid carcinoma (HP:0002890)1.55434233
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55341345
73Basal ganglia calcification (HP:0002135)1.55293003
74Leiomyosarcoma (HP:0100243)1.51904426
75Uterine leiomyosarcoma (HP:0002891)1.51904426
76Vertigo (HP:0002321)1.50530426
77Lower limb amyotrophy (HP:0007210)1.47870286
78Testicular neoplasm (HP:0010788)1.47598498
79Transitional cell carcinoma of the bladder (HP:0006740)1.46792913
80Abnormality of alanine metabolism (HP:0010916)1.46459233
81Hyperalaninemia (HP:0003348)1.46459233
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.46459233
83Mitral stenosis (HP:0001718)1.45399635
84Termporal pattern (HP:0011008)1.43837060
85Insidious onset (HP:0003587)1.43837060
86Autoimmune hemolytic anemia (HP:0001890)1.41251618
87Back pain (HP:0003418)1.40886045
88Absent/shortened dynein arms (HP:0200106)1.38148529
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.38148529
90Mucosal telangiectasiae (HP:0100579)1.36725715
91Ileus (HP:0002595)1.36029054
92Abnormal spermatogenesis (HP:0008669)1.34327756
93Abnormality of the Achilles tendon (HP:0005109)1.33271590
94Abnormal respiratory motile cilium physiology (HP:0012261)1.32952942
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.30793910
96Bladder neoplasm (HP:0009725)1.30377153
97Bladder carcinoma (HP:0002862)1.30377153
98Neoplasm of the rectum (HP:0100743)1.29549157
99Central scotoma (HP:0000603)1.29527344
100Hypertriglyceridemia (HP:0002155)1.28531035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.68111040
2RIPK44.91340253
3BMX4.41290567
4MYLK4.06162870
5EIF2AK13.24593908
6BTK2.92675735
7TEC2.89288862
8PTK2B2.84970189
9ILK2.40645768
10GRK52.30058646
11TAOK32.23920717
12CSF1R2.17226390
13SYK2.03225895
14ZAP701.97129913
15PIK3CG1.95706203
16MAPKAPK31.90133029
17GRK61.88495402
18BMPR21.87835340
19FGR1.63022283
20STK31.55489697
21PLK21.49404707
22DAPK31.36194804
23PAK11.34365832
24ADRBK21.33444980
25HCK1.26857970
26LMTK21.24861977
27ACVR1B1.17237808
28PIM21.15794331
29PNCK1.15646492
30TLK11.12523678
31BLK1.10892686
32IKBKB1.09520968
33LYN1.06409553
34TNIK1.06248007
35EPHB21.05172100
36STK241.04130760
37FES1.03874424
38TNK21.03507753
39MATK0.97315267
40EPHA30.91750829
41MAP2K30.87902338
42ADRBK10.86791931
43MAP3K50.86059743
44TRIM280.85553167
45RET0.84184294
46DAPK20.83641050
47PKN10.81959375
48ERBB20.80606636
49TAOK20.79275412
50IRAK10.76904217
51PRKD10.76648118
52MARK30.76339506
53ITK0.75966782
54NUAK10.72620218
55FER0.72410803
56SIK30.71493519
57ARAF0.71249306
58TESK20.69858098
59BMPR1B0.65884231
60TXK0.65683094
61MINK10.65109415
62DAPK10.62334619
63MAP4K20.58043460
64MAPK120.53832216
65CSK0.53744389
66PDGFRB0.53015350
67PRKACG0.52141416
68TAOK10.51306636
69MAP3K120.49840356
70MAPK130.44584057
71MAP2K10.43801133
72PDK10.43628977
73GRK10.43319261
74PAK30.42372341
75PRKG10.40520686
76ZAK0.40488336
77FYN0.39617287
78STK40.39240947
79ROCK10.36287748
80LCK0.35226573
81MAP3K30.35196008
82CDK140.33730990
83PDPK10.33356152
84PRKCD0.32481671
85PRKCB0.29725334
86IRAK30.28496268
87PRKCA0.27274334
88CDK80.26164435
89JAK20.25849745
90CAMK2G0.25244931
91SRC0.25118589
92EPHB10.24359378
93IGF1R0.23801597
94DYRK1A0.22522171
95PRKCQ0.22514443
96CAMK2A0.21528532
97YES10.21489992
98PRKCE0.20970480
99IRAK20.20579441
100PIM10.19981870

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.73822139
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.86221297
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.28413582
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.69339513
5ECM-receptor interaction_Homo sapiens_hsa045122.57229974
6Arachidonic acid metabolism_Homo sapiens_hsa005902.32845640
7Hematopoietic cell lineage_Homo sapiens_hsa046402.30285076
8Nitrogen metabolism_Homo sapiens_hsa009102.17334607
9Gap junction_Homo sapiens_hsa045402.03383343
10Serotonergic synapse_Homo sapiens_hsa047261.86281922
11Vascular smooth muscle contraction_Homo sapiens_hsa042701.85735732
12Chemokine signaling pathway_Homo sapiens_hsa040621.83701402
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77057572
14Collecting duct acid secretion_Homo sapiens_hsa049661.70827479
15Alcoholism_Homo sapiens_hsa050341.66414295
16Systemic lupus erythematosus_Homo sapiens_hsa053221.53990185
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51310857
18Sulfur metabolism_Homo sapiens_hsa009201.48658118
19Endocytosis_Homo sapiens_hsa041441.38391027
20Shigellosis_Homo sapiens_hsa051311.33396228
21Glycerolipid metabolism_Homo sapiens_hsa005611.26109253
22Pancreatic secretion_Homo sapiens_hsa049721.25132013
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21294390
24Glutathione metabolism_Homo sapiens_hsa004801.18947607
25Fatty acid elongation_Homo sapiens_hsa000621.14920335
26Linoleic acid metabolism_Homo sapiens_hsa005911.12468653
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.08036575
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07297688
29B cell receptor signaling pathway_Homo sapiens_hsa046621.05418899
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00608516
31Leukocyte transendothelial migration_Homo sapiens_hsa046700.99966005
32Circadian entrainment_Homo sapiens_hsa047130.98916971
33Olfactory transduction_Homo sapiens_hsa047400.97858327
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96533063
35Morphine addiction_Homo sapiens_hsa050320.95672249
36Long-term depression_Homo sapiens_hsa047300.93477309
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92417610
38Focal adhesion_Homo sapiens_hsa045100.88767962
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86793851
40Mismatch repair_Homo sapiens_hsa034300.86757910
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85115849
42T cell receptor signaling pathway_Homo sapiens_hsa046600.83241496
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81901605
44Rap1 signaling pathway_Homo sapiens_hsa040150.81017577
45Phagosome_Homo sapiens_hsa041450.80449885
46Fat digestion and absorption_Homo sapiens_hsa049750.77628886
47Starch and sucrose metabolism_Homo sapiens_hsa005000.75478988
48Renin-angiotensin system_Homo sapiens_hsa046140.72989615
49GABAergic synapse_Homo sapiens_hsa047270.70869530
50Primary immunodeficiency_Homo sapiens_hsa053400.70425234
51Choline metabolism in cancer_Homo sapiens_hsa052310.70030958
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68637874
53Calcium signaling pathway_Homo sapiens_hsa040200.66825199
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66675414
55Ras signaling pathway_Homo sapiens_hsa040140.66172925
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.65735290
57Malaria_Homo sapiens_hsa051440.65450565
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61073521
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60344559
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60046932
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59166818
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.58669263
63Endometrial cancer_Homo sapiens_hsa052130.58296746
64Pancreatic cancer_Homo sapiens_hsa052120.57439085
65Melanoma_Homo sapiens_hsa052180.55218359
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54514089
67Viral carcinogenesis_Homo sapiens_hsa052030.54458405
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53231350
69Cholinergic synapse_Homo sapiens_hsa047250.52674109
70Chemical carcinogenesis_Homo sapiens_hsa052040.52573925
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52314487
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51899822
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50939479
74Dilated cardiomyopathy_Homo sapiens_hsa054140.50754851
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50311426
76Phototransduction_Homo sapiens_hsa047440.50124733
77Synaptic vesicle cycle_Homo sapiens_hsa047210.48972514
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48032053
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47417963
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45414646
81Renin secretion_Homo sapiens_hsa049240.45304045
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45077960
83Sphingolipid metabolism_Homo sapiens_hsa006000.44361007
84Gastric acid secretion_Homo sapiens_hsa049710.43181259
85Glioma_Homo sapiens_hsa052140.42476301
86Small cell lung cancer_Homo sapiens_hsa052220.42232822
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41759517
88Non-small cell lung cancer_Homo sapiens_hsa052230.41130703
89Pentose phosphate pathway_Homo sapiens_hsa000300.40169067
90Glutamatergic synapse_Homo sapiens_hsa047240.40076041
91Salmonella infection_Homo sapiens_hsa051320.37706332
92Asthma_Homo sapiens_hsa053100.37389907
93PPAR signaling pathway_Homo sapiens_hsa033200.37293080
94beta-Alanine metabolism_Homo sapiens_hsa004100.36941392
95Staphylococcus aureus infection_Homo sapiens_hsa051500.36351034
96Apoptosis_Homo sapiens_hsa042100.36242820
97Osteoclast differentiation_Homo sapiens_hsa043800.35366955
98Amoebiasis_Homo sapiens_hsa051460.34402545
99Thyroid cancer_Homo sapiens_hsa052160.33089867
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32713861

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