SCGB2A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of vascular permeability (GO:0043117)9.63745735
2negative regulation of T cell apoptotic process (GO:0070233)9.25654442
3regulation of gonadotropin secretion (GO:0032276)8.90274842
4hydrogen peroxide catabolic process (GO:0042744)8.64324043
5positive regulation of uterine smooth muscle contraction (GO:0070474)8.40673733
6positive regulation of neurotransmitter secretion (GO:0001956)8.27101665
7mitochondrial calcium ion transport (GO:0006851)7.43780550
8retina homeostasis (GO:0001895)7.25141700
9mitochondrion distribution (GO:0048311)7.21967144
10regulation of uterine smooth muscle contraction (GO:0070472)6.66878572
11mannosylation (GO:0097502)6.60735318
12xenobiotic catabolic process (GO:0042178)6.26278144
13detection of chemical stimulus (GO:0009593)6.20020269
14negative regulation of lymphocyte apoptotic process (GO:0070229)6.09813835
15platelet dense granule organization (GO:0060155)6.02387627
16positive regulation of neurotransmitter transport (GO:0051590)5.85511566
17protein maturation by protein folding (GO:0022417)5.70839846
18response to nitrosative stress (GO:0051409)5.52349335
19endothelial cell chemotaxis (GO:0035767)5.29210535
20regulation of T cell apoptotic process (GO:0070232)5.13810171
21C21-steroid hormone biosynthetic process (GO:0006700)5.02824643
22COPI coating of Golgi vesicle (GO:0048205)5.00798579
23Golgi transport vesicle coating (GO:0048200)5.00798579
24prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.94708902
25hydrogen peroxide metabolic process (GO:0042743)4.72814251
26L-ascorbic acid metabolic process (GO:0019852)4.67960262
27regulation of triglyceride biosynthetic process (GO:0010866)4.64528624
28synapsis (GO:0007129)4.60270698
29cell aggregation (GO:0098743)4.48442539
30cartilage condensation (GO:0001502)4.48442539
31GPI anchor biosynthetic process (GO:0006506)4.45112013
32signal peptide processing (GO:0006465)4.44871096
33negative regulation of leukocyte apoptotic process (GO:2000107)4.40717858
34regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.34400803
35phasic smooth muscle contraction (GO:0014821)4.33275577
36preassembly of GPI anchor in ER membrane (GO:0016254)4.21937085
37negative regulation of protein autophosphorylation (GO:0031953)4.21857095
38regulation of protein glycosylation (GO:0060049)4.11723181
39detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)36.7990216
40GPI anchor metabolic process (GO:0006505)3.95808514
41hair cycle (GO:0042633)3.95697984
42molting cycle (GO:0042303)3.95697984
43diol metabolic process (GO:0034311)3.94810162
44prostate gland growth (GO:0060736)3.93909337
45viral mRNA export from host cell nucleus (GO:0046784)3.86813694
46valine metabolic process (GO:0006573)3.80572932
47galactose metabolic process (GO:0006012)3.79978761
48positive regulation of glomerulus development (GO:0090193)3.79262007
49cellular copper ion homeostasis (GO:0006878)3.73928626
50positive regulation of fibroblast migration (GO:0010763)3.71798756
51regulation of phospholipase A2 activity (GO:0032429)3.71097577
52positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.70660890
53glutathione derivative biosynthetic process (GO:1901687)3.70579013
54glutathione derivative metabolic process (GO:1901685)3.70579013
55cellular response to oxygen radical (GO:0071450)3.69524570
56removal of superoxide radicals (GO:0019430)3.69524570
57cellular response to superoxide (GO:0071451)3.69524570
58cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.68320498
59cellular response to gonadotropin stimulus (GO:0071371)3.65229636
60regulation of cell proliferation involved in kidney development (GO:1901722)3.64119416
61ethanol oxidation (GO:0006069)3.61862689
62blastocyst development (GO:0001824)3.61774382
63negative regulation of gluconeogenesis (GO:0045721)3.60164948
64cellular zinc ion homeostasis (GO:0006882)3.58945730
65sphingoid metabolic process (GO:0046519)3.55928205
66cellular response to antibiotic (GO:0071236)3.55666313
67toxin transport (GO:1901998)3.52334090
68short-chain fatty acid metabolic process (GO:0046459)3.49792985
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.43602621
70glycoprotein catabolic process (GO:0006516)3.41549714
71branched-chain amino acid catabolic process (GO:0009083)3.40324931
72methionine biosynthetic process (GO:0009086)3.38911370
73embryonic body morphogenesis (GO:0010172)3.37873360
74mitochondrion localization (GO:0051646)3.37321389
75water-soluble vitamin biosynthetic process (GO:0042364)3.31595609
76activation of NF-kappaB-inducing kinase activity (GO:0007250)3.29927011
77protein retention in ER lumen (GO:0006621)3.28956575
78activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.26024122
79import into cell (GO:0098657)3.25941503
80negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.24160438
81maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18845717
82sphingomyelin metabolic process (GO:0006684)3.18260359
83benzene-containing compound metabolic process (GO:0042537)3.17652725
84response to xenobiotic stimulus (GO:0009410)3.17586853
85regulation of lymphocyte apoptotic process (GO:0070228)3.13997155
86transcytosis (GO:0045056)3.13547322
87ethanol metabolic process (GO:0006067)3.13013738
88zinc ion transport (GO:0006829)3.12287468
89positive regulation of nuclease activity (GO:0032075)3.11627949
90inositol metabolic process (GO:0006020)3.09731738
91S-adenosylmethionine metabolic process (GO:0046500)3.08318471
92response to interferon-beta (GO:0035456)3.07446833
93response to oxygen radical (GO:0000305)3.06229668
94GTP biosynthetic process (GO:0006183)3.05650027
95sphingolipid catabolic process (GO:0030149)3.03742856
96branched-chain amino acid metabolic process (GO:0009081)3.03508140
97negative regulation of mRNA metabolic process (GO:1903312)3.02608618
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01858807
99heart contraction (GO:0060047)3.01122287
100heart process (GO:0003015)3.01122287
101protein complex biogenesis (GO:0070271)3.00894134
102Golgi organization (GO:0007030)3.00355706
103detection of chemical stimulus involved in sensory perception of taste (GO:0050912)21.6164723
104COPII vesicle coating (GO:0048208)2.99256052
105regulation of clathrin-mediated endocytosis (GO:2000369)2.98870929
106regulation of mitochondrial depolarization (GO:0051900)2.98583821
107regulation of triglyceride metabolic process (GO:0090207)2.97035118
108negative regulation of transcription by competitive promoter binding (GO:0010944)2.96850508
109membrane lipid catabolic process (GO:0046466)2.96232663
110branching involved in labyrinthine layer morphogenesis (GO:0060670)2.96151249
111iron ion import (GO:0097286)2.93112856
112chemosensory behavior (GO:0007635)2.92908533
113positive regulation of smooth muscle contraction (GO:0045987)2.91480487
114positive regulation of T cell differentiation in thymus (GO:0033089)2.88803852
115positive regulation of amine transport (GO:0051954)2.86514338
116mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86318403
117filopodium assembly (GO:0046847)2.86256591
118exogenous drug catabolic process (GO:0042738)2.85682600
119zinc ion homeostasis (GO:0055069)2.85593650
120respiratory chain complex IV assembly (GO:0008535)2.85456058
121endoplasmic reticulum unfolded protein response (GO:0030968)2.85163356
122lysine metabolic process (GO:0006553)2.84669183
123lysine catabolic process (GO:0006554)2.84669183
124proline biosynthetic process (GO:0006561)2.81908942
125SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.81741151
126regulation of vascular permeability (GO:0043114)2.81638341
127anterograde synaptic vesicle transport (GO:0048490)2.81022578
128regulation of nuclease activity (GO:0032069)2.79512509
129ER-nucleus signaling pathway (GO:0006984)2.79154466
130alpha-linolenic acid metabolic process (GO:0036109)2.77854756
131ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.76254635
132cytochrome complex assembly (GO:0017004)2.76177464
133positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.75805231
134cellular response to unfolded protein (GO:0034620)2.74721688
135regulation of lipoprotein metabolic process (GO:0050746)2.74491043
136retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73817543
137metaphase plate congression (GO:0051310)2.73052140
138auditory receptor cell stereocilium organization (GO:0060088)2.72502075
139protein heterotrimerization (GO:0070208)2.71008253
140labyrinthine layer blood vessel development (GO:0060716)2.70534230
141copper ion homeostasis (GO:0055070)2.70425418
142vesicle coating (GO:0006901)2.63819186
143lung secretory cell differentiation (GO:0061140)2.62258402
144UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62145656
145glandular epithelial cell differentiation (GO:0002067)2.56231525
146acetyl-CoA metabolic process (GO:0006084)2.52444454
147negative regulation of response to reactive oxygen species (GO:1901032)2.50832344
148cellular response to topologically incorrect protein (GO:0035967)2.48435227
149coenzyme catabolic process (GO:0009109)2.46822998
150exocrine pancreas development (GO:0031017)2.43069821
151protein N-linked glycosylation via asparagine (GO:0018279)2.41657302
152peptidyl-asparagine modification (GO:0018196)2.40455840
153response to endoplasmic reticulum stress (GO:0034976)2.39317810
154protein targeting to Golgi (GO:0000042)2.36811880
155response to unfolded protein (GO:0006986)2.35912564
156aspartate family amino acid catabolic process (GO:0009068)2.31335875
157peroxisome fission (GO:0016559)2.27754812
158protein N-linked glycosylation (GO:0006487)2.22828512
159negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.22048037
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.18979739
161response to topologically incorrect protein (GO:0035966)2.18377860
162regulation of leukocyte apoptotic process (GO:2000106)2.16947760
163amino-acid betaine metabolic process (GO:0006577)2.16275757
164cellular response to hydrogen peroxide (GO:0070301)2.14639775
165negative regulation of receptor-mediated endocytosis (GO:0048261)2.14238039
166erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.13605142
167L-phenylalanine catabolic process (GO:0006559)2.13605142
168fatty acid oxidation (GO:0019395)2.13322852
169positive regulation of glycoprotein metabolic process (GO:1903020)2.11293389
170localization within membrane (GO:0051668)2.11195020
171regulation of short-term neuronal synaptic plasticity (GO:0048172)2.10097436
172lipid oxidation (GO:0034440)2.09103789
173synaptic vesicle docking involved in exocytosis (GO:0016081)2.08556221
174endoplasmic reticulum organization (GO:0007029)2.06245654
175fatty acid catabolic process (GO:0009062)2.05288821
176establishment of protein localization to Golgi (GO:0072600)2.04574083
177retrograde transport, vesicle recycling within Golgi (GO:0000301)2.04249510
178bile acid biosynthetic process (GO:0006699)2.03762255
179cardiac muscle cell proliferation (GO:0060038)2.03354930
180protein localization to Golgi apparatus (GO:0034067)2.03220114
181detection of chemical stimulus involved in sensory perception (GO:0050907)18.9474207
182tachykinin receptor signaling pathway (GO:0007217)10.0137480
183positive regulation of regulated secretory pathway (GO:1903307)1.96459858
184lung cell differentiation (GO:0060479)1.95934404
185erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.95137388
186L-phenylalanine metabolic process (GO:0006558)1.95137388
187bundle of His cell to Purkinje myocyte communication (GO:0086069)1.93212960
188nerve growth factor signaling pathway (GO:0038180)1.92076576
189thioester biosynthetic process (GO:0035384)1.91837591
190acyl-CoA biosynthetic process (GO:0071616)1.91837591
191sulfur amino acid catabolic process (GO:0000098)1.91244898
192regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.90859841
193germ cell migration (GO:0008354)1.90492573
194xenobiotic metabolic process (GO:0006805)1.90358892
195ER overload response (GO:0006983)1.90178989
196proline metabolic process (GO:0006560)1.89815191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human8.06966835
2AR_21909140_ChIP-Seq_LNCAP_Human4.85779903
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.62517305
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.51294900
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23011844
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.18339368
7STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.77174534
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.72824129
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68519829
10TFEB_21752829_ChIP-Seq_HELA_Human2.67493060
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.63787613
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.52474548
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48631954
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33734835
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30856604
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.24178825
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.22647503
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18742762
19GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse2.17701447
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.12018973
21DNAJC2_21179169_ChIP-ChIP_NT2_Human2.08849211
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07934852
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05581933
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98380591
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95767915
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.95605977
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94853910
28CLOCK_20551151_ChIP-Seq_293T_Human1.91753169
29EGR1_19032775_ChIP-ChIP_M12_Human1.90485920
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87127795
31CBP_21632823_ChIP-Seq_H3396_Human1.82692862
32ZNF263_19887448_ChIP-Seq_K562_Human1.81636311
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80955841
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78011788
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.73286150
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73078422
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68341443
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.67426269
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.64049781
40TAF15_26573619_Chip-Seq_HEK293_Human1.62066771
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61036331
42RACK7_27058665_Chip-Seq_MCF-7_Human1.57142754
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.54627744
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.53054919
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.52022558
46* CBP_20019798_ChIP-Seq_JUKART_Human1.49784458
47* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49784458
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48580000
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.46808925
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46751131
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.44444950
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.43323010
53* FOXH1_21741376_ChIP-Seq_EPCs_Human1.43322864
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41713534
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41500377
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39742660
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38638822
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.38602949
59* FOXA2_19822575_ChIP-Seq_HepG2_Human1.35847066
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35781265
61HOXB7_26014856_ChIP-Seq_BT474_Human1.35089193
62GATA3_24758297_ChIP-Seq_MCF-7_Human1.32156261
63* NCOR_22424771_ChIP-Seq_293T_Human1.31498273
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31469418
65LXR_22292898_ChIP-Seq_THP-1_Human1.31227382
66SOX2_20726797_ChIP-Seq_SW620_Human1.31210132
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30400129
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.29401043
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28280778
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25658419
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25294309
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25100061
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24722704
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24443180
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24290852
76STAT1_17558387_ChIP-Seq_HELA_Human1.22270089
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.21837546
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21557648
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21474501
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21187236
81GATA6_25053715_ChIP-Seq_YYC3_Human1.20567938
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19944012
83GATA3_26560356_Chip-Seq_TH2_Human1.19491072
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19168062
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17662387
86GATA4_25053715_ChIP-Seq_YYC3_Human1.16091577
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15946165
88LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15714823
89CEBPB_22108803_ChIP-Seq_LS180_Human1.15294415
90CDX2_22108803_ChIP-Seq_LS180_Human1.14666485
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14138239
92* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.13271024
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11866986
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11238707
95KDM2B_26808549_Chip-Seq_REH_Human1.11140342
96ELF5_23300383_ChIP-Seq_T47D_Human1.10106913
97GATA1_22025678_ChIP-Seq_K562_Human1.08987164
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08167697
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07889127
100TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07252021
101ZNF274_21170338_ChIP-Seq_K562_Hela1.07151725
102GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05864164
103* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05639987
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05451044
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04120422
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02981130
107GBX2_23144817_ChIP-Seq_PC3_Human1.02032423
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01939981
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01689709
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01245840
111FUS_26573619_Chip-Seq_HEK293_Human1.00896449
112AHR_22903824_ChIP-Seq_MCF-7_Human1.00229242
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99783320
114FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99596378
115GATA3_21867929_ChIP-Seq_TH1_Mouse0.98581070
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98017905
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97818544
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97801608
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97515491
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97275484
121EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96848411
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96848411
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96106897
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94796880
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93712487
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92704849
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.92416144
128TRIM28_21343339_ChIP-Seq_HEK293_Human0.91849793
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91843675
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91767560
131FOXH1_21741376_ChIP-Seq_ESCs_Human0.91282710
132AR_19668381_ChIP-Seq_PC3_Human0.91068885
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90773976
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89622350
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89450878
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89069980
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89050721
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88787176
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88492707
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88318225
141PHF8_20622853_ChIP-Seq_HELA_Human0.86771829
142HNFA_21074721_ChIP-Seq_CACO-2_Human0.86212285
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.86036452
144RARB_27405468_Chip-Seq_BRAIN_Mouse0.85554628
145CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85390653
146EZH2_27294783_Chip-Seq_ESCs_Mouse0.84573359
147CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84459896
148CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84149367
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83756371
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82428562
151GATA6_21074721_ChIP-Seq_CACO-2_Human0.81759549
152IRF1_19129219_ChIP-ChIP_H3396_Human0.81633590
153CHD1_26751641_Chip-Seq_LNCaP_Human0.81392900
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.81346235
155E2F1_21310950_ChIP-Seq_MCF-7_Human0.79636996
156CTCF_27219007_Chip-Seq_Bcells_Human0.79030697
157HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78714032
158WDR5_24793694_ChIP-Seq_LNCAP_Human0.76720824
159EOMES_21245162_ChIP-Seq_HESCs_Human0.76542221
160DCP1A_22483619_ChIP-Seq_HELA_Human0.76137195
161* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75112621
162* FOXA1_25329375_ChIP-Seq_VCAP_Human0.75112621
163TBL1_22424771_ChIP-Seq_293T_Human0.73458381
164RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73326086
165LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.73218507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland7.83318725
2MP0010030_abnormal_orbit_morphology6.13947206
3MP0002822_catalepsy5.54435312
4MP0000372_irregular_coat_pigmentation5.18602640
5MP0004381_abnormal_hair_follicle4.84270321
6MP0005423_abnormal_somatic_nervous3.94160033
7MP0003279_aneurysm3.93722520
8MP0009780_abnormal_chondrocyte_physiolo3.88017680
9MP0005248_abnormal_Harderian_gland3.82487028
10MP0000613_abnormal_salivary_gland3.56231625
11MP0002282_abnormal_trachea_morphology3.55847003
12MP0005220_abnormal_exocrine_pancreas3.49272066
13MP0002009_preneoplasia3.19936133
14MP0005623_abnormal_meninges_morphology3.05119125
15MP0008995_early_reproductive_senescence2.87709704
16MP0005646_abnormal_pituitary_gland2.65527802
17MP0000015_abnormal_ear_pigmentation2.65100851
18MP0005365_abnormal_bile_salt2.48681339
19MP0006292_abnormal_olfactory_placode2.46095510
20MP0001919_abnormal_reproductive_system2.44037751
21MP0005332_abnormal_amino_acid2.34043077
22MP0005647_abnormal_sex_gland2.32039765
23MP0010307_abnormal_tumor_latency2.29880556
24MP0009764_decreased_sensitivity_to2.29391903
25MP0001666_abnormal_nutrient_absorption2.23362328
26MP0000537_abnormal_urethra_morphology2.17784282
27MP0008872_abnormal_physiological_respon2.17005875
28MP0002896_abnormal_bone_mineralization2.15801582
29MP0003690_abnormal_glial_cell2.11279247
30MP0010234_abnormal_vibrissa_follicle2.05903417
31MP0004264_abnormal_extraembryonic_tissu2.04814978
32MP0003638_abnormal_response/metabolism_2.04639572
33MP0005085_abnormal_gallbladder_physiolo1.95786010
34MP0000427_abnormal_hair_cycle1.94730258
35MP0005670_abnormal_white_adipose1.91501309
36MP0003806_abnormal_nucleotide_metabolis1.90534858
37MP0000747_muscle_weakness1.87148099
38MP0003786_premature_aging1.77624714
39MP0002160_abnormal_reproductive_system1.76731417
40MP0005389_reproductive_system_phenotype1.72820672
41MP0004233_abnormal_muscle_weight1.71021728
42MP0000579_abnormal_nail_morphology1.69255758
43MP0001177_atelectasis1.68383191
44MP0001881_abnormal_mammary_gland1.66803298
45MP0005075_abnormal_melanosome_morpholog1.66705727
46MP0005083_abnormal_biliary_tract1.59625690
47MP0002938_white_spotting1.51012306
48MP0005360_urolithiasis1.42931851
49MP0004883_abnormal_blood_vessel1.42564232
50MP0005645_abnormal_hypothalamus_physiol1.42127028
51MP0003252_abnormal_bile_duct1.40545160
52MP0004019_abnormal_vitamin_homeostasis1.40426511
53MP0002736_abnormal_nociception_after1.38336568
54MP0003633_abnormal_nervous_system1.37299388
55MP0002139_abnormal_hepatobiliary_system1.33915904
56MP0004859_abnormal_synaptic_plasticity1.33105176
57MP0003632_abnormal_nervous_system1.32931617
58MP0000858_altered_metastatic_potential1.32793953
59MP0000767_abnormal_smooth_muscle1.30370293
60MP0002090_abnormal_vision1.29938802
61MP0008875_abnormal_xenobiotic_pharmacok1.29130327
62MP0000371_diluted_coat_color1.28644609
63MP0001299_abnormal_eye_distance/1.27546798
64MP0001533_abnormal_skeleton_physiology1.27505952
65MP0009384_cardiac_valve_regurgitation1.27143839
66MP0009765_abnormal_xenobiotic_induced1.26636307
67MP0004145_abnormal_muscle_electrophysio1.25551055
68MP0003631_nervous_system_phenotype1.24459992
69MP0002006_tumorigenesis1.24439905
70MP0003329_amyloid_beta_deposits1.23867098
71MP0005197_abnormal_uvea_morphology1.23481201
72MP0001243_abnormal_dermal_layer1.19320873
73MP0000377_abnormal_hair_follicle1.17823661
74MP0004270_analgesia1.14640944
75MP0005167_abnormal_blood-brain_barrier1.14389058
76MP0002254_reproductive_system_inflammat1.13291368
77MP0001944_abnormal_pancreas_morphology1.10255264
78MP0004272_abnormal_basement_membrane1.09512635
79MP0005058_abnormal_lysosome_morphology1.07982009
80MP0003191_abnormal_cellular_cholesterol1.07925008
81MP0005410_abnormal_fertilization1.07638238
82MP0003705_abnormal_hypodermis_morpholog1.07534387
83MP0002098_abnormal_vibrissa_morphology1.06858852
84MP0010329_abnormal_lipoprotein_level1.05407167
85MP0003828_pulmonary_edema1.04946695
86MP0001542_abnormal_bone_strength1.04655216
87MP0000367_abnormal_coat/_hair1.04145661
88MP0004130_abnormal_muscle_cell1.03329765
89MP0002735_abnormal_chemical_nociception1.01912171
90MP0000013_abnormal_adipose_tissue0.97771806
91MP0000358_abnormal_cell_content/0.97133635
92MP0003123_paternal_imprinting0.96667879
93MP0003959_abnormal_lean_body0.96432093
94MP0002166_altered_tumor_susceptibility0.95903314
95MP0000920_abnormal_myelination0.95505232
96MP0005174_abnormal_tail_pigmentation0.94389118
97MP0002118_abnormal_lipid_homeostasis0.93503779
98MP0004858_abnormal_nervous_system0.92282507
99MP0009785_altered_susceptibility_to0.91784148
100MP0002557_abnormal_social/conspecific_i0.91601291
101MP0003755_abnormal_palate_morphology0.88192544
102MP0002064_seizures0.87257216
103MP0000538_abnormal_urinary_bladder0.86575333
104MP0005187_abnormal_penis_morphology0.86564306
105MP0003566_abnormal_cell_adhesion0.85313093
106MP0001348_abnormal_lacrimal_gland0.84683242
107MP0005319_abnormal_enzyme/_coenzyme0.84205609
108MP0001501_abnormal_sleep_pattern0.83994355
109MP0005379_endocrine/exocrine_gland_phen0.83279563
110MP0003635_abnormal_synaptic_transmissio0.83251731
111MP0003938_abnormal_ear_development0.81741411
112MP0002115_abnormal_skeleton_extremities0.81667618
113MP0009643_abnormal_urine_homeostasis0.81245652
114MP0000470_abnormal_stomach_morphology0.80638045
115MP0008789_abnormal_olfactory_epithelium0.77380558
116MP0003011_delayed_dark_adaptation0.76955440
117MP0000534_abnormal_ureter_morphology0.74515891
118MP0004085_abnormal_heartbeat0.74503120
119MP0008438_abnormal_cutaneous_collagen0.74440836
120MP0002970_abnormal_white_adipose0.71983545
121MP0000163_abnormal_cartilage_morphology0.71453148
122MP0005023_abnormal_wound_healing0.71340242
123MP0000778_abnormal_nervous_system0.71164475
124MP0000604_amyloidosis0.69092548
125MP0000762_abnormal_tongue_morphology0.68363394
126MP0005584_abnormal_enzyme/coenzyme_acti0.68156984
127MP0009672_abnormal_birth_weight0.67636303
128MP0002277_abnormal_respiratory_mucosa0.67329903
129MP0000609_abnormal_liver_physiology0.66256762
130MP0003718_maternal_effect0.66172085
131MP0004185_abnormal_adipocyte_glucose0.65880072
132MP0002332_abnormal_exercise_endurance0.65647361
133MP0003890_abnormal_embryonic-extraembry0.64191783
134MP0005636_abnormal_mineral_homeostasis0.63711968
135MP0004036_abnormal_muscle_relaxation0.62584676
136MP0003075_altered_response_to0.61855740
137MP0003172_abnormal_lysosome_physiology0.61707891
138MP0002909_abnormal_adrenal_gland0.60874003
139MP0002108_abnormal_muscle_morphology0.60429478
140MP0001324_abnormal_eye_pigmentation0.59882586
141MP0000598_abnormal_liver_morphology0.58313772
142MP0006276_abnormal_autonomic_nervous0.58154924
143MP0010630_abnormal_cardiac_muscle0.57295051
144MP0005388_respiratory_system_phenotype0.56998983
145MP0002133_abnormal_respiratory_system0.56998983
146MP0000631_abnormal_neuroendocrine_gland0.56374113
147MP0008873_increased_physiological_sensi0.56356771
148MP0008961_abnormal_basal_metabolism0.56036404
149MP0003868_abnormal_feces_composition0.55632562
150MP0005381_digestive/alimentary_phenotyp0.55519773
151MP0001968_abnormal_touch/_nociception0.55255000
152MP0010368_abnormal_lymphatic_system0.54924455
153MP0003936_abnormal_reproductive_system0.54728405
154MP0005390_skeleton_phenotype0.54282803
155MP0002697_abnormal_eye_size0.54228527
156MP0005408_hypopigmentation0.53922378
157MP0002092_abnormal_eye_morphology0.53694399
158MP0000462_abnormal_digestive_system0.52417066
159MP0002796_impaired_skin_barrier0.52400797
160MP0004087_abnormal_muscle_fiber0.51680411
161MP0001663_abnormal_digestive_system0.50976702
162MP0003656_abnormal_erythrocyte_physiolo0.50969146
163MP0005334_abnormal_fat_pad0.49882617
164MP0002136_abnormal_kidney_physiology0.49834587
165MP0002078_abnormal_glucose_homeostasis0.49783530
166MP0001765_abnormal_ion_homeostasis0.49625385
167MP0010386_abnormal_urinary_bladder0.49377242
168MP0006082_CNS_inflammation0.48434354
169MP0002272_abnormal_nervous_system0.48400256
170MP0003195_calcinosis0.47556923
171MP0005164_abnormal_response_to0.46861317
172MP0003795_abnormal_bone_structure0.46735933
173MP0001191_abnormal_skin_condition0.46509958
174MP0001756_abnormal_urination0.46173821
175MP0002083_premature_death0.45463093
176MP0009840_abnormal_foam_cell0.44341942

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)7.61071161
2Fibular aplasia (HP:0002990)6.79378646
3Spontaneous abortion (HP:0005268)6.43704735
4Chronic sinusitis (HP:0011109)6.24047673
5Tented upper lip vermilion (HP:0010804)5.94922166
6Mesomelia (HP:0003027)5.67216331
7Abnormal cartilage morphology (HP:0002763)5.57698443
8Short 1st metacarpal (HP:0010034)5.33591232
9Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.33591232
10Pulmonary artery stenosis (HP:0004415)5.32817696
11Nasal speech (HP:0001611)5.13775608
12Sensorimotor neuropathy (HP:0007141)5.05674637
13Aplasia of the musculature (HP:0100854)5.00999469
14Abnormality of the phalanges of the 2nd finger (HP:0009541)4.92432615
15Concave nail (HP:0001598)4.73130622
16Cortical dysplasia (HP:0002539)4.69812235
17Aplasia/Hypoplasia involving the musculature (HP:0001460)4.68790049
18Abnormality of the 1st metacarpal (HP:0010009)4.66122363
19Recurrent bronchitis (HP:0002837)4.65971350
20Amniotic constriction ring (HP:0009775)4.63100630
21Abnormality of placental membranes (HP:0011409)4.63100630
22Synostosis involving the elbow (HP:0003938)4.62196477
23Humeroradial synostosis (HP:0003041)4.62196477
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.56945106
25Spastic diplegia (HP:0001264)4.42224287
26Large eyes (HP:0001090)4.29887352
27Deep philtrum (HP:0002002)4.22728848
28Slender build (HP:0001533)4.17253797
29Ependymoma (HP:0002888)4.15926816
30Abnormal pupillary function (HP:0007686)4.11605053
31Enlarged epiphyses (HP:0010580)4.10566855
32Sparse lateral eyebrow (HP:0005338)4.01108688
33Albinism (HP:0001022)3.99657292
34Parakeratosis (HP:0001036)3.95422840
35Abnormality of the proximal phalanges of the hand (HP:0009834)3.93914598
36Radial bowing (HP:0002986)3.78107950
37Glossoptosis (HP:0000162)3.76916584
38Deformed tarsal bones (HP:0008119)3.70525798
39Hypoplastic pelvis (HP:0008839)3.67945290
40Abnormality of the 2nd finger (HP:0004100)3.60991167
41Abnormality involving the epiphyses of the upper limbs (HP:0003839)3.57667430
42Abnormality of the epiphyses of the hand (HP:0005924)3.54187883
43Gonadotropin excess (HP:0000837)3.41130642
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.33487658
45Abnormality of the middle phalanges of the toes (HP:0010183)3.23305620
46Short phalanx of the thumb (HP:0009660)3.22852453
47Symphalangism affecting the phalanges of the hand (HP:0009773)3.22046786
482-3 toe syndactyly (HP:0004691)3.20385416
49Fibular hypoplasia (HP:0003038)3.16093964
50Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.08977659
51Adactyly (HP:0009776)3.07217667
52Abnormality of the phalanges of the 5th finger (HP:0004213)3.03643984
53Anteriorly placed anus (HP:0001545)3.01831413
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.00216498
55Astrocytoma (HP:0009592)2.98738666
56Abnormality of the astrocytes (HP:0100707)2.98738666
57Epiphyseal stippling (HP:0010655)2.94973771
58Generalized amyotrophy (HP:0003700)2.94026767
59Bowing of the arm (HP:0006488)2.92566322
60Bowed forearm bones (HP:0003956)2.92566322
61Abnormality of fatty-acid metabolism (HP:0004359)2.90402415
62Hypoplastic ischia (HP:0003175)2.89774787
63Increased CSF protein (HP:0002922)2.89146923
64Narrow nasal bridge (HP:0000446)2.84574477
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.84026345
66Bronchitis (HP:0012387)2.83741167
67Ankyloglossia (HP:0010296)2.83382560
68Short tibia (HP:0005736)2.82534797
69Flat capital femoral epiphysis (HP:0003370)2.75335012
70Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.74612563
71Aplasia/Hypoplasia of the fibula (HP:0006492)2.71993856
72Long palpebral fissure (HP:0000637)2.70306262
73Testicular atrophy (HP:0000029)2.68762933
74Hypochromic microcytic anemia (HP:0004840)2.67049211
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.66826860
76Abnormality of the intrinsic pathway (HP:0010989)2.66243798
77Right ventricular cardiomyopathy (HP:0011663)2.64763020
78Short metatarsal (HP:0010743)2.64418543
79Short hallux (HP:0010109)2.64241487
80Conjugated hyperbilirubinemia (HP:0002908)2.63653918
81Volvulus (HP:0002580)2.63077647
82Deep venous thrombosis (HP:0002625)2.62816270
83Anosmia (HP:0000458)2.61089704
84Hypoplasia of the pons (HP:0012110)2.58184814
85Short thumb (HP:0009778)2.56877371
86Abnormality of the ischium (HP:0003174)2.56067474
87Coronal craniosynostosis (HP:0004440)2.54558282
88Aplasia/Hypoplasia of the hallux (HP:0008362)2.54473364
89Infantile muscular hypotonia (HP:0008947)2.53811834
90Ketosis (HP:0001946)2.49825231
91Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.49440803
92Abnormality of the common coagulation pathway (HP:0010990)2.49084776
93Abnormality of carpal bone ossification (HP:0006257)2.48657080
94Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.44701201
95Hyperkalemia (HP:0002153)2.44294659
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38844311
97Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.33259999
98Generalized hypopigmentation (HP:0007513)2.32078888
99Generalized hypopigmentation of hair (HP:0011358)2.31960946
100Back pain (HP:0003418)2.31201854
101Limb-girdle muscle atrophy (HP:0003797)2.30004807
102Vertebral hypoplasia (HP:0008417)2.29428145
103Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.29428145
104Pseudobulbar signs (HP:0002200)2.29406067
105Tracheal stenosis (HP:0002777)2.28679860
106Malnutrition (HP:0004395)2.28274043
107Abnormality of the salivary glands (HP:0010286)2.27208087
108Aplasia/Hypoplasia of the tibia (HP:0005772)2.25962543
109Glioma (HP:0009733)2.24712291
110Abnormality of the pons (HP:0007361)2.24146905
111Nasolacrimal duct obstruction (HP:0000579)2.23063987
112Reticulocytopenia (HP:0001896)2.20695927
113Vascular calcification (HP:0004934)2.20597886
114Microcytic anemia (HP:0001935)2.17809294
115Premature skin wrinkling (HP:0100678)2.16678518
116Hypokinesia (HP:0002375)2.14981192
117Rimmed vacuoles (HP:0003805)2.14807001
118Loss of speech (HP:0002371)2.14529764
119Increased cerebral lipofuscin (HP:0011813)2.14412961
120Congenital glaucoma (HP:0001087)2.13817962
121Cardiovascular calcification (HP:0011915)2.13074432
122Duplicated collecting system (HP:0000081)2.12800972
123Fragile skin (HP:0001030)2.09604668
124Abnormality of oral frenula (HP:0000190)2.09527776
125Easy fatigability (HP:0003388)2.09088996
126Large earlobe (HP:0009748)2.08244436
127Congenital ichthyosiform erythroderma (HP:0007431)2.07699379
128Hypoparathyroidism (HP:0000829)2.06456029
129Short humerus (HP:0005792)2.05369973
130Broad nasal tip (HP:0000455)2.05113932
131Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04191764
132Abnormality of nail color (HP:0100643)2.03582704
133Axonal loss (HP:0003447)2.03118690
134Asplenia (HP:0001746)2.02727362
135Camptodactyly of toe (HP:0001836)2.02074846
136Lip pit (HP:0100267)2.00502028
137Abnormality of the renal collecting system (HP:0004742)1.99577342
138Cerebral inclusion bodies (HP:0100314)1.96997962
139Shawl scrotum (HP:0000049)1.96592010
140Cardiomegaly (HP:0001640)1.95967147
141Hypoplastic left heart (HP:0004383)1.95568327
142Ketoacidosis (HP:0001993)1.94966591
143Diaphragmatic weakness (HP:0009113)1.94932417
144Hyperglycinuria (HP:0003108)1.94404550
145Myelomeningocele (HP:0002475)1.93830232
146Midface retrusion (HP:0011800)1.91800933
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.90531754
148Visual hallucinations (HP:0002367)1.89090121
149Absent speech (HP:0001344)1.88869695
150Hypochromic anemia (HP:0001931)1.88811602
151Calf muscle hypertrophy (HP:0008981)1.86037895
152Hyperglycinemia (HP:0002154)1.85626475
153Abnormality of glycine metabolism (HP:0010895)1.85479175
154Abnormality of serine family amino acid metabolism (HP:0010894)1.85479175
155Short distal phalanx of finger (HP:0009882)1.84203104
156Abnormal epiphyseal ossification (HP:0010656)1.83179572
157Femoral bowing (HP:0002980)1.80838706
158Rhizomelia (HP:0008905)1.80593373
159Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.79287895
160High anterior hairline (HP:0009890)1.78037029
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.76784720
162Hypoplastic scapulae (HP:0000882)1.76621547
163Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76621547
164Wrist flexion contracture (HP:0001239)1.75584830
165Ocular albinism (HP:0001107)1.75287818
166Aplasia/hypoplasia of the humerus (HP:0006507)1.74369416
167Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.74005517
168Abdominal distention (HP:0003270)1.73094308
169Protuberant abdomen (HP:0001538)1.72250129
170Agnosia (HP:0010524)1.72096782
171Abnormal hand bone ossification (HP:0010660)1.71869427
172Rectal prolapse (HP:0002035)1.71781422
173Megalocornea (HP:0000485)1.71593155
174Intrahepatic cholestasis (HP:0001406)1.70214288
175Spinal rigidity (HP:0003306)1.67495179
176Tapered finger (HP:0001182)1.67101396
177Abnormal ossification of hand bones (HP:0005921)1.65914692
178Hypoplasia of the iris (HP:0007676)1.65674463
179Broad hallux (HP:0010055)1.64497273
180J-shaped sella turcica (HP:0002680)1.63961662
181Underdeveloped nasal alae (HP:0000430)1.63366538
182Muscle hypertrophy of the lower extremities (HP:0008968)1.63217005
183Chromsome breakage (HP:0040012)1.63214231
184Recurrent otitis media (HP:0000403)1.62705791
185Stillbirth (HP:0003826)1.61839252
186Abnormality of abdominal situs (HP:0011620)1.61045166
187Abdominal situs inversus (HP:0003363)1.61045166
188Insidious onset (HP:0003587)1.60931613
189Termporal pattern (HP:0011008)1.60931613
190Short middle phalanx of finger (HP:0005819)1.59547829
191Wide nose (HP:0000445)1.54572274
192Xanthomatosis (HP:0000991)1.54166636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.76267574
2PRKCI4.37416073
3ERN13.49869895
4LATS13.49047587
5FGFR13.45717574
6IRAK33.18831102
7MST42.96960801
8FER2.93786787
9TNK22.80024038
10PDK42.76644589
11PDK32.76644589
12STK392.74588231
13TAOK32.37487161
14MAP2K42.29754166
15MAP3K92.18902504
16ERBB32.16110445
17WNK42.15987583
18MAP3K42.11014409
19NEK61.98197120
20TRIB31.96909371
21EIF2AK11.86196474
22GSK3A1.81394783
23WEE11.79023159
24EEF2K1.76956464
25PAK11.76636462
26NME21.65606582
27PIK3CA1.55651499
28CHUK1.54927646
29PKN21.54914287
30EPHB11.53079642
31PDK21.44378555
32TLK11.41204574
33MAP2K71.34036587
34DMPK1.32103023
35HIPK21.28491326
36IKBKE1.28045142
37MAP3K21.25715572
38PTK61.25387405
39RET1.24316285
40NTRK11.23322899
41FRK1.20563769
42RPS6KA21.18582955
43UHMK11.13039491
44NME11.11560764
45NTRK31.09656543
46MST1R1.07870530
47LATS21.02273932
48MET0.99179399
49MAP3K70.95525333
50EIF2AK30.94876368
51RPS6KL10.94122753
52RPS6KC10.94122753
53WNK10.93158111
54TRIM280.92361947
55BMX0.90341002
56SCYL20.90207693
57RPS6KA60.88371018
58MAP2K60.88370043
59MAPKAPK30.86978825
60GRK10.83708254
61AKT20.79568373
62KSR20.79259373
63IRAK20.77423637
64PAK30.77149265
65RPS6KB20.75622898
66LRRK20.73385197
67STK38L0.73027387
68CDK70.69995939
69IKBKB0.69910861
70EPHA30.69836817
71STK100.69338904
72INSRR0.68492460
73IRAK40.67391194
74PDGFRA0.66931607
75ABL10.64586323
76CASK0.64083683
77MAPK90.62963308
78TTN0.62705149
79EIF2AK20.62470793
80TEC0.62283360
81DDR20.60351723
82PAK60.60078266
83CDK50.59815773
84MAP2K30.59373615
85EPHA40.58549050
86RIPK10.57607655
87MELK0.56520267
88MINK10.54941136
89STK380.53837343
90MARK20.53473459
91MAP2K20.53393051
92IRAK10.53270348
93MAPK150.52440754
94PTK20.52417800
95TYRO30.52223844
96GRK60.52223696
97MAPK40.52125505
98AKT30.50707999
99PDPK10.49961157
100IGF1R0.49367373
101PRKD10.48611370
102BRSK20.48139509
103ERBB20.48005528
104FLT30.47679843
105TAOK10.47378306
106PDK10.46523918
107PAK20.45140932
108CSNK1G30.45019726
109DAPK20.43918236
110MAP3K100.43324867
111RPS6KA10.42196433
112SIK10.42167189
113CDK190.41242662
114TRPM70.41211715
115MAPK120.40477557
116FGFR40.40086404
117MAPKAPK20.39918587
118MTOR0.39602222
119CDK30.39490592
120MAP3K140.38419759
121ALK0.38213455
122EPHA20.37296605
123FYN0.36811010
124CSNK1G10.36562756
125MAPK30.36152371
126STK30.36148927
127INSR0.35475069
128RPS6KB10.34999530
129CSNK1E0.34472275
130FES0.33944169
131PRKCQ0.33911827
132CSNK1A1L0.33763378
133JAK20.33688736
134MATK0.32791848
135AURKA0.29940283
136TIE10.29455842
137GRK70.29121006
138BMPR20.28294280
139PKN10.28237621
140FGR0.28120597
141PRKCH0.27921473
142OXSR10.26538084
143BCR0.26397220
144GRK50.25911191
145MARK10.24621195
146SRC0.24565000
147CDK60.24305222
148FGFR20.24191875
149NUAK10.22992358
150CAMKK10.22923550
151GSK3B0.22435344
152ROCK20.22198831
153CHEK10.21238485
154LMTK20.21124324
155MAP2K10.20249240
156RPS6KA30.20053300
157PDGFRB0.19878531
158JAK10.18998741
159TSSK60.17952201
160CDK150.17727139
161CSNK1G20.17694746
162ROCK10.17347829
163CAMK2D0.17335585
164VRK20.16762628
165TESK10.16366365
166CSNK2A10.16310531
167CSNK2A20.15566321
168PRKCZ0.14931036
169MAP3K80.14853011
170DYRK20.14553371
171ABL20.14261713
172MAPK70.14173826
173PBK0.12731818
174DAPK10.12615152

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.73033525
2Salivary secretion_Homo sapiens_hsa049704.38458048
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.32903969
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.23828190
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.96026875
6Sulfur relay system_Homo sapiens_hsa041223.93692390
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90369123
8Proteasome_Homo sapiens_hsa030502.89933157
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.82781816
10Propanoate metabolism_Homo sapiens_hsa006402.72221621
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.71107778
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.57195052
13Shigellosis_Homo sapiens_hsa051312.38507480
14Glutathione metabolism_Homo sapiens_hsa004802.37666306
15Oxidative phosphorylation_Homo sapiens_hsa001902.28039003
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17832590
17Vitamin B6 metabolism_Homo sapiens_hsa007502.14551522
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13936069
19Sulfur metabolism_Homo sapiens_hsa009201.99626315
20Fatty acid degradation_Homo sapiens_hsa000711.93079726
21Nitrogen metabolism_Homo sapiens_hsa009101.86617635
22Sphingolipid metabolism_Homo sapiens_hsa006001.85249849
23Collecting duct acid secretion_Homo sapiens_hsa049661.82920298
24Steroid biosynthesis_Homo sapiens_hsa001001.72348647
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72099840
26Pyruvate metabolism_Homo sapiens_hsa006201.68993093
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66382207
28beta-Alanine metabolism_Homo sapiens_hsa004101.58784628
29Dorso-ventral axis formation_Homo sapiens_hsa043201.57957775
30Parkinsons disease_Homo sapiens_hsa050121.53464440
31Arginine biosynthesis_Homo sapiens_hsa002201.52394980
32Phototransduction_Homo sapiens_hsa047441.48115649
33Mismatch repair_Homo sapiens_hsa034301.47652066
34Peroxisome_Homo sapiens_hsa041461.45087792
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37033164
36Histidine metabolism_Homo sapiens_hsa003401.36757155
37Selenocompound metabolism_Homo sapiens_hsa004501.36574658
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35003711
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30072324
40Tryptophan metabolism_Homo sapiens_hsa003801.27282921
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23882341
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22746768
43Butanoate metabolism_Homo sapiens_hsa006501.22475628
44Fanconi anemia pathway_Homo sapiens_hsa034601.20840036
45Alzheimers disease_Homo sapiens_hsa050101.19594993
46B cell receptor signaling pathway_Homo sapiens_hsa046621.18923983
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13944784
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12564088
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07029067
50N-Glycan biosynthesis_Homo sapiens_hsa005101.01534580
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.01324018
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99105199
53Bile secretion_Homo sapiens_hsa049760.98843448
54Biosynthesis of amino acids_Homo sapiens_hsa012300.95483727
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93173510
56Arginine and proline metabolism_Homo sapiens_hsa003300.89944570
57Fatty acid metabolism_Homo sapiens_hsa012120.89885638
58Carbon metabolism_Homo sapiens_hsa012000.88859333
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82741708
60Huntingtons disease_Homo sapiens_hsa050160.81864987
61Linoleic acid metabolism_Homo sapiens_hsa005910.80616342
62Insulin secretion_Homo sapiens_hsa049110.76816292
63Long-term potentiation_Homo sapiens_hsa047200.74806043
64Lysine degradation_Homo sapiens_hsa003100.73330800
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73055011
66T cell receptor signaling pathway_Homo sapiens_hsa046600.71014533
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67577396
68Thyroid hormone synthesis_Homo sapiens_hsa049180.65893478
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64299609
70PPAR signaling pathway_Homo sapiens_hsa033200.62803240
71Dopaminergic synapse_Homo sapiens_hsa047280.62480766
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62466225
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61323364
74RNA degradation_Homo sapiens_hsa030180.60995880
75Insulin resistance_Homo sapiens_hsa049310.59835118
76Estrogen signaling pathway_Homo sapiens_hsa049150.59808672
77Mineral absorption_Homo sapiens_hsa049780.59224023
78Gastric acid secretion_Homo sapiens_hsa049710.58332586
79Pancreatic secretion_Homo sapiens_hsa049720.58076087
80Cholinergic synapse_Homo sapiens_hsa047250.57558959
81GABAergic synapse_Homo sapiens_hsa047270.57423897
82Vibrio cholerae infection_Homo sapiens_hsa051100.56989307
83Folate biosynthesis_Homo sapiens_hsa007900.56377886
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56174979
85Basal transcription factors_Homo sapiens_hsa030220.56106626
86DNA replication_Homo sapiens_hsa030300.55791269
87Glycerolipid metabolism_Homo sapiens_hsa005610.55684079
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55479514
89Primary immunodeficiency_Homo sapiens_hsa053400.55167626
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54983357
91Amphetamine addiction_Homo sapiens_hsa050310.52955316
92Circadian rhythm_Homo sapiens_hsa047100.52833934
93Retinol metabolism_Homo sapiens_hsa008300.52212472
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51463462
95Type II diabetes mellitus_Homo sapiens_hsa049300.51024356
96Proteoglycans in cancer_Homo sapiens_hsa052050.50122377
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49922289
98Synaptic vesicle cycle_Homo sapiens_hsa047210.49053174
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49021666
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48922863
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.48393590
102Complement and coagulation cascades_Homo sapiens_hsa046100.48318138
103Arachidonic acid metabolism_Homo sapiens_hsa005900.48091809
104Renin secretion_Homo sapiens_hsa049240.47624811
105Chemical carcinogenesis_Homo sapiens_hsa052040.47459147
106Cardiac muscle contraction_Homo sapiens_hsa042600.46833191
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46388918
108Metabolic pathways_Homo sapiens_hsa011000.45791555
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45665625
110Glucagon signaling pathway_Homo sapiens_hsa049220.45617699
111Cocaine addiction_Homo sapiens_hsa050300.44876925
112Tyrosine metabolism_Homo sapiens_hsa003500.40938931
113Circadian entrainment_Homo sapiens_hsa047130.40769353
114Glutamatergic synapse_Homo sapiens_hsa047240.40719163
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39387325
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38481407
117Fatty acid elongation_Homo sapiens_hsa000620.36934147
118Ovarian steroidogenesis_Homo sapiens_hsa049130.36655211
119ErbB signaling pathway_Homo sapiens_hsa040120.36499043
120RNA transport_Homo sapiens_hsa030130.35986360
121GnRH signaling pathway_Homo sapiens_hsa049120.35781903
122mTOR signaling pathway_Homo sapiens_hsa041500.35554858
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35249569
124Lysosome_Homo sapiens_hsa041420.34243749
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.33326461
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32625656
127Melanogenesis_Homo sapiens_hsa049160.31414490
128Prion diseases_Homo sapiens_hsa050200.30341172
129Tight junction_Homo sapiens_hsa045300.29975155
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.29870307
131Phenylalanine metabolism_Homo sapiens_hsa003600.29659864
132One carbon pool by folate_Homo sapiens_hsa006700.29658687
133Adherens junction_Homo sapiens_hsa045200.29580559
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.27519604
135Glioma_Homo sapiens_hsa052140.27209909
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.27080185
137ABC transporters_Homo sapiens_hsa020100.26812410
138Morphine addiction_Homo sapiens_hsa050320.26798494
139cAMP signaling pathway_Homo sapiens_hsa040240.26384698
140Hepatitis C_Homo sapiens_hsa051600.25973849
141Vitamin digestion and absorption_Homo sapiens_hsa049770.25958184
142Endocytosis_Homo sapiens_hsa041440.25402450
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24905044
144Pertussis_Homo sapiens_hsa051330.24638331
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23930573
146Rheumatoid arthritis_Homo sapiens_hsa053230.23224444
147Pyrimidine metabolism_Homo sapiens_hsa002400.20913179
148Fructose and mannose metabolism_Homo sapiens_hsa000510.20401422
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20312029
150Endometrial cancer_Homo sapiens_hsa052130.19917461
151Fat digestion and absorption_Homo sapiens_hsa049750.19608935
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.18942389
153Gap junction_Homo sapiens_hsa045400.18800989
154Herpes simplex infection_Homo sapiens_hsa051680.18512005
155MAPK signaling pathway_Homo sapiens_hsa040100.15681895
156Phagosome_Homo sapiens_hsa041450.15567095
157Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14055890
158Calcium signaling pathway_Homo sapiens_hsa040200.13509619
159Prolactin signaling pathway_Homo sapiens_hsa049170.10144030
160Caffeine metabolism_Homo sapiens_hsa002320.09846186

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