SCGB2B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell apoptotic process (GO:0070233)9.19112046
2hydrogen peroxide catabolic process (GO:0042744)8.59649371
3mitochondrial calcium ion transport (GO:0006851)7.39237971
4retina homeostasis (GO:0001895)7.20841250
5mitochondrion distribution (GO:0048311)7.16630436
6detection of chemical stimulus (GO:0009593)6.19412352
7negative regulation of lymphocyte apoptotic process (GO:0070229)6.04802881
8regulation of T cell apoptotic process (GO:0070232)5.10360090
9COPI coating of Golgi vesicle (GO:0048205)5.01142138
10Golgi transport vesicle coating (GO:0048200)5.01142138
11tachykinin receptor signaling pathway (GO:0007217)4.73642356
12hydrogen peroxide metabolic process (GO:0042743)4.71930812
13signal peptide processing (GO:0006465)4.45352775
14negative regulation of leukocyte apoptotic process (GO:2000107)4.38091972
15piRNA metabolic process (GO:0034587)4.27162795
16regulation of cilium movement (GO:0003352)4.23940175
17cellular ketone body metabolic process (GO:0046950)4.08333812
18detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)36.5932656
19DNA methylation involved in gamete generation (GO:0043046)3.95683360
20neuronal action potential propagation (GO:0019227)3.93363343
21valine metabolic process (GO:0006573)3.81498223
22positive regulation of mitochondrial fission (GO:0090141)3.75965826
23galactose metabolic process (GO:0006012)3.75929865
24cellular copper ion homeostasis (GO:0006878)3.72437759
25gamma-aminobutyric acid transport (GO:0015812)3.68046596
26ethanol oxidation (GO:0006069)3.64112004
27protein polyglutamylation (GO:0018095)3.61783342
28ketone body metabolic process (GO:1902224)3.58474546
29axoneme assembly (GO:0035082)3.57205344
30indole-containing compound catabolic process (GO:0042436)3.54443227
31indolalkylamine catabolic process (GO:0046218)3.54443227
32tryptophan catabolic process (GO:0006569)3.54443227
33indolalkylamine metabolic process (GO:0006586)3.52559854
34short-chain fatty acid metabolic process (GO:0046459)3.50282345
35kynurenine metabolic process (GO:0070189)3.48937259
36nonmotile primary cilium assembly (GO:0035058)3.43810548
37cilium or flagellum-dependent cell motility (GO:0001539)3.43025672
38branched-chain amino acid catabolic process (GO:0009083)3.42621807
39glycoprotein catabolic process (GO:0006516)3.39826887
40photoreceptor cell maintenance (GO:0045494)3.39709715
41sperm motility (GO:0030317)3.35849612
42protein K11-linked deubiquitination (GO:0035871)3.35441678
43mitochondrion localization (GO:0051646)3.33848314
44detection of light stimulus involved in visual perception (GO:0050908)3.26462409
45detection of light stimulus involved in sensory perception (GO:0050962)3.26462409
46epithelial cilium movement (GO:0003351)3.26104065
47neural tube formation (GO:0001841)3.25815828
48protein retention in ER lumen (GO:0006621)3.24870725
49activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.24840369
50positive regulation of digestive system process (GO:0060456)3.22654326
51negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18041571
52tryptophan metabolic process (GO:0006568)3.17512065
53centriole replication (GO:0007099)3.15820424
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15012066
55ethanol metabolic process (GO:0006067)3.14721044
56transcytosis (GO:0045056)3.13929449
57regulation of lymphocyte apoptotic process (GO:0070228)3.11520046
58reflex (GO:0060004)3.10671504
59positive regulation of nuclease activity (GO:0032075)3.09711579
60positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.08375743
61mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.08375743
62pyrimidine nucleobase catabolic process (GO:0006208)3.07866745
63C4-dicarboxylate transport (GO:0015740)3.06234134
64branched-chain amino acid metabolic process (GO:0009081)3.05972741
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05382392
66behavioral response to nicotine (GO:0035095)3.05345565
67mannosylation (GO:0097502)3.03268748
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.02376927
69fucose catabolic process (GO:0019317)3.01549847
70L-fucose metabolic process (GO:0042354)3.01549847
71L-fucose catabolic process (GO:0042355)3.01549847
72regulation of action potential (GO:0098900)3.00898775
73detection of chemical stimulus involved in sensory perception of taste (GO:0050912)21.4996973
74positive regulation of action potential (GO:0045760)2.99752784
75Golgi organization (GO:0007030)2.98697040
76regulation of clathrin-mediated endocytosis (GO:2000369)2.97675625
77glycosphingolipid biosynthetic process (GO:0006688)2.97581439
78COPII vesicle coating (GO:0048208)2.97115239
79response to pheromone (GO:0019236)2.96521274
80cilium organization (GO:0044782)2.95699550
81cilium assembly (GO:0042384)2.93504254
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93441311
83regulation of microtubule-based movement (GO:0060632)2.93301094
84microtubule nucleation (GO:0007020)2.92326341
85acrosome reaction (GO:0007340)2.91420149
86cilium movement (GO:0003341)2.88746302
87lysine catabolic process (GO:0006554)2.86270529
88lysine metabolic process (GO:0006553)2.86270529
89indole-containing compound metabolic process (GO:0042430)2.84913037
90endoplasmic reticulum unfolded protein response (GO:0030968)2.84132002
91platelet dense granule organization (GO:0060155)2.83674741
92behavioral response to ethanol (GO:0048149)2.83112745
93nucleobase catabolic process (GO:0046113)2.81844774
94alpha-linolenic acid metabolic process (GO:0036109)2.80561402
95cilium morphogenesis (GO:0060271)2.80327002
96limb development (GO:0060173)2.80184185
97appendage development (GO:0048736)2.80184185
98oxidative demethylation (GO:0070989)2.78717079
99ER-nucleus signaling pathway (GO:0006984)2.78470159
100regulation of nuclease activity (GO:0032069)2.77330363
101proline biosynthetic process (GO:0006561)2.75948311
102retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75487577
103primary amino compound metabolic process (GO:1901160)2.75174833
104ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.75048021
105cell wall macromolecule catabolic process (GO:0016998)2.73898316
106cellular response to unfolded protein (GO:0034620)2.73827093
107copper ion homeostasis (GO:0055070)2.71278939
108negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70724508
109intraciliary transport (GO:0042073)2.69658284
110regulation of mitochondrial fission (GO:0090140)2.68228886
111postsynaptic membrane organization (GO:0001941)2.67723187
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66844464
113serotonin metabolic process (GO:0042428)2.65293065
114single strand break repair (GO:0000012)2.62536886
115vesicle coating (GO:0006901)2.62218145
116benzene-containing compound metabolic process (GO:0042537)2.61864459
117synaptic transmission, glutamatergic (GO:0035249)2.61858360
118UDP-N-acetylglucosamine metabolic process (GO:0006047)2.60883543
119male meiosis (GO:0007140)2.60768494
120amine catabolic process (GO:0009310)2.60000601
121cellular biogenic amine catabolic process (GO:0042402)2.60000601
122regulation of meiosis I (GO:0060631)2.59683373
123reciprocal meiotic recombination (GO:0007131)2.59207474
124reciprocal DNA recombination (GO:0035825)2.59207474
125startle response (GO:0001964)2.57510980
126lung secretory cell differentiation (GO:0061140)2.57305851
127righting reflex (GO:0060013)2.56500385
128interkinetic nuclear migration (GO:0022027)2.55606737
129auditory receptor cell stereocilium organization (GO:0060088)2.55478595
130multicellular organism reproduction (GO:0032504)2.54661691
131glandular epithelial cell differentiation (GO:0002067)2.54363716
132protein localization to synapse (GO:0035418)2.53651521
133synapsis (GO:0007129)2.52589206
134cell wall macromolecule metabolic process (GO:0044036)2.52577737
135acetyl-CoA metabolic process (GO:0006084)2.51936771
136ubiquinone metabolic process (GO:0006743)2.51177565
137regulation of glucokinase activity (GO:0033131)2.51138105
138regulation of hexokinase activity (GO:1903299)2.51138105
139acrosome assembly (GO:0001675)2.51056725
140negative regulation of response to reactive oxygen species (GO:1901032)2.49796333
141neuronal action potential (GO:0019228)2.49620069
142neuron cell-cell adhesion (GO:0007158)2.49271246
143ubiquinone biosynthetic process (GO:0006744)2.49160166
144spermatid development (GO:0007286)2.48927518
145cellular response to topologically incorrect protein (GO:0035967)2.47717495
146coenzyme catabolic process (GO:0009109)2.46228163
147DNA double-strand break processing (GO:0000729)2.45987053
148male meiosis I (GO:0007141)2.45932324
149inner ear receptor stereocilium organization (GO:0060122)2.45881159
150presynaptic membrane assembly (GO:0097105)2.44753109
151exocrine pancreas development (GO:0031017)2.42230865
152protein N-linked glycosylation via asparagine (GO:0018279)2.40856765
153peptidyl-asparagine modification (GO:0018196)2.39786956
154response to endoplasmic reticulum stress (GO:0034976)2.39146270
155response to unfolded protein (GO:0006986)2.34949527
156protein targeting to Golgi (GO:0000042)2.34031809
157aspartate family amino acid catabolic process (GO:0009068)2.32161008
158peroxisome fission (GO:0016559)2.27475278
159protein N-linked glycosylation (GO:0006487)2.22057979
160negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.19834826
161epithelial cell differentiation involved in prostate gland development (GO:0060742)2.18957184
162amino-acid betaine metabolic process (GO:0006577)2.18490330
163response to topologically incorrect protein (GO:0035966)2.17606000
164regulation of leukocyte apoptotic process (GO:2000106)2.15740641
165fatty acid oxidation (GO:0019395)2.15509679
166L-phenylalanine catabolic process (GO:0006559)2.14946400
167erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.14946400
168negative regulation of receptor-mediated endocytosis (GO:0048261)2.12865647
169positive regulation of glycoprotein metabolic process (GO:1903020)2.12731542
170cellular response to hydrogen peroxide (GO:0070301)2.12413048
171lipid oxidation (GO:0034440)2.11334180
172synaptic vesicle docking involved in exocytosis (GO:0016081)2.10391941
173regulation of short-term neuronal synaptic plasticity (GO:0048172)2.09975344
174fatty acid catabolic process (GO:0009062)2.07569844
175localization within membrane (GO:0051668)2.06890905
176bile acid biosynthetic process (GO:0006699)2.05179127
177endoplasmic reticulum organization (GO:0007029)2.04131597
178establishment of protein localization to Golgi (GO:0072600)2.03184701
179retrograde transport, vesicle recycling within Golgi (GO:0000301)2.02327161
180cardiac muscle cell proliferation (GO:0060038)2.01815008
181protein localization to Golgi apparatus (GO:0034067)2.00401595
182detection of chemical stimulus involved in sensory perception (GO:0050907)18.8454387
183erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.97143245
184L-phenylalanine metabolic process (GO:0006558)1.97143245
185positive regulation of regulated secretory pathway (GO:1903307)1.97022816
186bundle of His cell to Purkinje myocyte communication (GO:0086069)1.94954743
187lung cell differentiation (GO:0060479)1.92961528
188sulfur amino acid catabolic process (GO:0000098)1.92510288
189thioester biosynthetic process (GO:0035384)1.92225515
190acyl-CoA biosynthetic process (GO:0071616)1.92225515
191germ cell migration (GO:0008354)1.90700206
192xenobiotic metabolic process (GO:0006805)1.90383293
193regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.89610212
194nerve growth factor signaling pathway (GO:0038180)1.89156772
195ER overload response (GO:0006983)1.88673872
196proline metabolic process (GO:0006560)1.87286252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human7.92773429
2AR_21909140_ChIP-Seq_LNCAP_Human4.65555772
3IGF1R_20145208_ChIP-Seq_DFB_Human3.65430323
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.62429167
5EZH2_22144423_ChIP-Seq_EOC_Human3.34235639
6GBX2_23144817_ChIP-Seq_PC3_Human3.25588289
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77690657
8VDR_22108803_ChIP-Seq_LS180_Human2.76429953
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.72696480
10STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.72576912
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62498279
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.60203612
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56324044
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55640263
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.51973785
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48262667
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40524803
18TAF15_26573619_Chip-Seq_HEK293_Human2.30052390
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27409278
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21915843
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.20522540
22P300_19829295_ChIP-Seq_ESCs_Human2.10199269
23DNAJC2_21179169_ChIP-ChIP_NT2_Human2.06043310
24SOX2_27498859_Chip-Seq_STOMACH_Mouse2.05993662
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05586438
26ER_23166858_ChIP-Seq_MCF-7_Human2.05203551
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03479593
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94182163
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.92782908
30CLOCK_20551151_ChIP-Seq_293T_Human1.90358301
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.88259761
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86954900
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85531239
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.83439112
35SMAD4_21799915_ChIP-Seq_A2780_Human1.80489351
36STAT3_23295773_ChIP-Seq_U87_Human1.77918339
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75445810
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75002321
39ZNF263_19887448_ChIP-Seq_K562_Human1.72226415
40BCAT_22108803_ChIP-Seq_LS180_Human1.66744382
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.65846043
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65532111
43TCF4_23295773_ChIP-Seq_U87_Human1.65194618
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64928494
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.64471790
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.62822697
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62281810
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62009579
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.61857207
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59485818
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59485818
52RACK7_27058665_Chip-Seq_MCF-7_Human1.53511353
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52990467
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52845064
55EWS_26573619_Chip-Seq_HEK293_Human1.52428130
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51068048
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50469779
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.50386676
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49839113
60IRF1_19129219_ChIP-ChIP_H3396_Human1.48972503
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.48410617
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47834869
63AR_25329375_ChIP-Seq_VCAP_Human1.46900815
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.45598138
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45565233
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45382566
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37769329
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37527965
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36072382
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35605417
71REST_21632747_ChIP-Seq_MESCs_Mouse1.35416096
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34969173
73RUNX2_22187159_ChIP-Seq_PCA_Human1.34933755
74AR_21572438_ChIP-Seq_LNCaP_Human1.33169807
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.32596639
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32439964
77TP53_22573176_ChIP-Seq_HFKS_Human1.31770329
78NANOG_19829295_ChIP-Seq_ESCs_Human1.31483305
79SOX2_19829295_ChIP-Seq_ESCs_Human1.31483305
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30266665
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30222746
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30031076
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30002568
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.29436017
85LXR_22292898_ChIP-Seq_THP-1_Human1.29231797
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.28315953
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28315953
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.28275870
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27880058
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27171193
91TCF4_22108803_ChIP-Seq_LS180_Human1.26996914
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26985584
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26562883
94SOX2_20726797_ChIP-Seq_SW620_Human1.26444286
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.26442635
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25909724
97DROSHA_22980978_ChIP-Seq_HELA_Human1.24931320
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24408763
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.23277134
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22986025
101CBP_20019798_ChIP-Seq_JUKART_Human1.22986025
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22745930
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22658540
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.22320206
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21443637
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20280552
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.20174275
108STAT1_17558387_ChIP-Seq_HELA_Human1.19772512
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19701696
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19582851
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19352077
112GATA1_22025678_ChIP-Seq_K562_Human1.18419439
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18235512
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17440433
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17078531
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.16800487
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16245392
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16016481
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15406207
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.15210730
121GATA6_25053715_ChIP-Seq_YYC3_Human1.15188962
122RNF2_27304074_Chip-Seq_NSC_Mouse1.14409406
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.13110806
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12706215
125CEBPB_22108803_ChIP-Seq_LS180_Human1.12565082
126LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11381046
127AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11319271
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11269161
129BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10332640
130KDM2B_26808549_Chip-Seq_REH_Human1.10149775
131NCOR_22424771_ChIP-Seq_293T_Human1.09868580
132REST_18959480_ChIP-ChIP_MESCs_Mouse1.09780320
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09579672
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.07674696
135FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07568062
136ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06839049
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06835328
138ELF5_23300383_ChIP-Seq_T47D_Human1.06574822
139EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05724268
140P53_22387025_ChIP-Seq_ESCs_Mouse1.05207894
141ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04664415
142ZNF274_21170338_ChIP-Seq_K562_Hela1.04569364
143CRX_20693478_ChIP-Seq_RETINA_Mouse1.04272806
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04267211
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04059968
146E2F1_18555785_Chip-Seq_ESCs_Mouse1.03779213
147P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03731051
148CDX2_22108803_ChIP-Seq_LS180_Human1.03453517
149CBX2_27304074_Chip-Seq_ESCs_Mouse1.03417596
150CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03387226
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03029425
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01194801
153FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00835857
154SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00521152
155OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00387048
156ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00169306
157HOXB7_26014856_ChIP-Seq_BT474_Human0.99551369
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98865677
159SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98335247
160EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98305073
161RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98305073
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96901697
163GATA3_21867929_ChIP-Seq_TH1_Mouse0.96625886
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96127077
165AHR_22903824_ChIP-Seq_MCF-7_Human0.95675078
166FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95666640
167CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95527162
168SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95118765
169FUS_26573619_Chip-Seq_HEK293_Human0.94491970
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93703686
171ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92440701
172TRIM28_21343339_ChIP-Seq_HEK293_Human0.90950285
173EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89945360
174ARNT_22903824_ChIP-Seq_MCF-7_Human0.89310114
175WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89183788
176KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89054741
177AR_19668381_ChIP-Seq_PC3_Human0.88767247
178ERG_21242973_ChIP-ChIP_JURKAT_Human0.88123705
179PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88028860
180FOXH1_21741376_ChIP-Seq_ESCs_Human0.87867265
181RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87014994
182CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86509032
183ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86095279
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85491902
185EZH2_27294783_Chip-Seq_ESCs_Mouse0.84676664
186KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84546211
187E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84390965
188JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83722081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland7.78213465
2MP0010030_abnormal_orbit_morphology6.05830845
3MP0009780_abnormal_chondrocyte_physiolo3.89068206
4MP0005248_abnormal_Harderian_gland3.76447245
5MP0000613_abnormal_salivary_gland3.51684434
6MP0005220_abnormal_exocrine_pancreas3.45712117
7MP0003195_calcinosis3.32668169
8MP0002009_preneoplasia3.26315368
9MP0005623_abnormal_meninges_morphology3.06589965
10MP0008877_abnormal_DNA_methylation2.99914704
11MP0001968_abnormal_touch/_nociception2.64377416
12MP0002837_dystrophic_cardiac_calcinosis2.63777744
13MP0005646_abnormal_pituitary_gland2.63597469
14MP0005365_abnormal_bile_salt2.55243351
15MP0004147_increased_porphyrin_level2.50806829
16MP0006292_abnormal_olfactory_placode2.35376370
17MP0005332_abnormal_amino_acid2.33549795
18MP0009764_decreased_sensitivity_to2.29267643
19MP0005551_abnormal_eye_electrophysiolog2.25088131
20MP0001666_abnormal_nutrient_absorption2.24099140
21MP0002102_abnormal_ear_morphology2.23925996
22MP0006276_abnormal_autonomic_nervous2.20510086
23MP0002896_abnormal_bone_mineralization2.15909841
24MP0003690_abnormal_glial_cell2.09672613
25MP0002736_abnormal_nociception_after2.09336752
26MP0000537_abnormal_urethra_morphology2.08185972
27MP0001501_abnormal_sleep_pattern2.06901248
28MP0009046_muscle_twitch2.04133538
29MP0004264_abnormal_extraembryonic_tissu2.02572440
30MP0005085_abnormal_gallbladder_physiolo2.01544846
31MP0010234_abnormal_vibrissa_follicle1.98846957
32MP0003806_abnormal_nucleotide_metabolis1.96718279
33MP0001984_abnormal_olfaction1.92957988
34MP0003787_abnormal_imprinting1.90280494
35MP0005645_abnormal_hypothalamus_physiol1.86949086
36MP0000747_muscle_weakness1.86458227
37MP0003880_abnormal_central_pattern1.85403794
38MP0003646_muscle_fatigue1.82807907
39MP0005253_abnormal_eye_physiology1.80618945
40MP0001529_abnormal_vocalization1.79930848
41MP0002138_abnormal_hepatobiliary_system1.79727641
42MP0000372_irregular_coat_pigmentation1.79587542
43MP0002653_abnormal_ependyma_morphology1.78428843
44MP0001486_abnormal_startle_reflex1.76086038
45MP0009745_abnormal_behavioral_response1.72615808
46MP0006072_abnormal_retinal_apoptosis1.70103159
47MP0000579_abnormal_nail_morphology1.69888522
48MP0004233_abnormal_muscle_weight1.68639796
49MP0004142_abnormal_muscle_tone1.67716876
50MP0002876_abnormal_thyroid_physiology1.65741435
51MP0005410_abnormal_fertilization1.65653746
52MP0002638_abnormal_pupillary_reflex1.65364769
53MP0001986_abnormal_taste_sensitivity1.64795709
54MP0002735_abnormal_chemical_nociception1.62523667
55MP0002822_catalepsy1.58292690
56MP0008872_abnormal_physiological_respon1.55069183
57MP0002572_abnormal_emotion/affect_behav1.53946723
58MP0005360_urolithiasis1.50110630
59MP0000013_abnormal_adipose_tissue1.43565667
60MP0004019_abnormal_vitamin_homeostasis1.42575613
61MP0002139_abnormal_hepatobiliary_system1.42346987
62MP0003698_abnormal_male_reproductive1.40432706
63MP0004885_abnormal_endolymph1.38407661
64MP0004859_abnormal_synaptic_plasticity1.37454612
65MP0003633_abnormal_nervous_system1.36411856
66MP0003136_yellow_coat_color1.36387916
67MP0000631_abnormal_neuroendocrine_gland1.33819291
68MP0008875_abnormal_xenobiotic_pharmacok1.33704803
69MP0002733_abnormal_thermal_nociception1.32685998
70MP0003632_abnormal_nervous_system1.32626597
71MP0000858_altered_metastatic_potential1.32461814
72MP0002557_abnormal_social/conspecific_i1.31222859
73MP0004145_abnormal_muscle_electrophysio1.31104681
74MP0001764_abnormal_homeostasis1.30830150
75MP0001533_abnormal_skeleton_physiology1.29711371
76MP0002067_abnormal_sensory_capabilities1.28185484
77MP0003329_amyloid_beta_deposits1.27037029
78MP0008058_abnormal_DNA_repair1.26591314
79MP0001970_abnormal_pain_threshold1.26224608
80MP0009384_cardiac_valve_regurgitation1.26044812
81MP0003011_delayed_dark_adaptation1.25947532
82MP0001299_abnormal_eye_distance/1.25760826
83MP0009765_abnormal_xenobiotic_induced1.25014298
84MP0000427_abnormal_hair_cycle1.24937392
85MP0003631_nervous_system_phenotype1.23878586
86MP0005197_abnormal_uvea_morphology1.22888658
87MP0002254_reproductive_system_inflammat1.19167691
88MP0002928_abnormal_bile_duct1.18871697
89MP0008057_abnormal_DNA_replication1.18559555
90MP0004270_analgesia1.18036596
91MP0002938_white_spotting1.16503370
92MP0005386_behavior/neurological_phenoty1.15023077
93MP0004924_abnormal_behavior1.15023077
94MP0004133_heterotaxia1.14215164
95MP0002160_abnormal_reproductive_system1.14008074
96MP0002063_abnormal_learning/memory/cond1.13279535
97MP0005167_abnormal_blood-brain_barrier1.12634909
98MP0005058_abnormal_lysosome_morphology1.12121007
99MP0004215_abnormal_myocardial_fiber1.12108490
100MP0001929_abnormal_gametogenesis1.11231665
101MP0001944_abnormal_pancreas_morphology1.10916650
102MP0010329_abnormal_lipoprotein_level1.10498275
103MP0005647_abnormal_sex_gland1.08177406
104MP0003191_abnormal_cellular_cholesterol1.07967054
105MP0003121_genomic_imprinting1.07609239
106MP0004272_abnormal_basement_membrane1.07384971
107MP0000569_abnormal_digit_pigmentation1.07236379
108MP0004130_abnormal_muscle_cell1.05474776
109MP0003252_abnormal_bile_duct1.05309029
110MP0005171_absent_coat_pigmentation1.02848897
111MP0002229_neurodegeneration1.00713095
112MP0003122_maternal_imprinting1.00411752
113MP0002166_altered_tumor_susceptibility1.00027527
114MP0003705_abnormal_hypodermis_morpholog0.99050131
115MP0003890_abnormal_embryonic-extraembry0.98294113
116MP0005499_abnormal_olfactory_system0.97719423
117MP0005394_taste/olfaction_phenotype0.97719423
118MP0002118_abnormal_lipid_homeostasis0.96107734
119MP0004858_abnormal_nervous_system0.94345896
120MP0002734_abnormal_mechanical_nocicepti0.94325765
121MP0002184_abnormal_innervation0.93858670
122MP0001270_distended_abdomen0.92407366
123MP0001485_abnormal_pinna_reflex0.92243859
124MP0003123_paternal_imprinting0.91434909
125MP0003718_maternal_effect0.91118779
126MP0000920_abnormal_myelination0.90470369
127MP0002090_abnormal_vision0.89667863
128MP0000383_abnormal_hair_follicle0.89413259
129MP0002210_abnormal_sex_determination0.89273880
130MP0001348_abnormal_lacrimal_gland0.88495430
131MP0002064_seizures0.88425872
132MP0005187_abnormal_penis_morphology0.86581899
133MP0005319_abnormal_enzyme/_coenzyme0.86439513
134MP0003635_abnormal_synaptic_transmissio0.86128568
135MP0005266_abnormal_metabolism0.85740671
136MP0001963_abnormal_hearing_physiology0.85400804
137MP0002752_abnormal_somatic_nervous0.84750468
138MP0009643_abnormal_urine_homeostasis0.82906573
139MP0003566_abnormal_cell_adhesion0.82390368
140MP0004043_abnormal_pH_regulation0.81477103
141MP0002115_abnormal_skeleton_extremities0.81427831
142MP0002751_abnormal_autonomic_nervous0.78692328
143MP0005084_abnormal_gallbladder_morpholo0.78186240
144MP0000470_abnormal_stomach_morphology0.77955245
145MP0002882_abnormal_neuron_morphology0.77038069
146MP0008789_abnormal_olfactory_epithelium0.75201618
147MP0008438_abnormal_cutaneous_collagen0.74312627
148MP0000653_abnormal_sex_gland0.73286814
149MP0000604_amyloidosis0.73169914
150MP0005195_abnormal_posterior_eye0.72673905
151MP0000163_abnormal_cartilage_morphology0.71140547
152MP0000778_abnormal_nervous_system0.70637658
153MP0005584_abnormal_enzyme/coenzyme_acti0.70059370
154MP0000609_abnormal_liver_physiology0.68829620
155MP0002332_abnormal_exercise_endurance0.67980946
156MP0002277_abnormal_respiratory_mucosa0.67527644
157MP0002909_abnormal_adrenal_gland0.66959572
158MP0005636_abnormal_mineral_homeostasis0.66294366
159MP0003075_altered_response_to0.65223785
160MP0000762_abnormal_tongue_morphology0.64264404
161MP0009672_abnormal_birth_weight0.63337694
162MP0004185_abnormal_adipocyte_glucose0.61939408
163MP0004036_abnormal_muscle_relaxation0.61345214
164MP0008961_abnormal_basal_metabolism0.59217829
165MP0000598_abnormal_liver_morphology0.57543213
166MP0005381_digestive/alimentary_phenotyp0.55883521
167MP0010386_abnormal_urinary_bladder0.55613998
168MP0003868_abnormal_feces_composition0.55235898
169MP0010368_abnormal_lymphatic_system0.54946602
170MP0005408_hypopigmentation0.54865624
171MP0005390_skeleton_phenotype0.54638071
172MP0010630_abnormal_cardiac_muscle0.54057811
173MP0001663_abnormal_digestive_system0.53048149
174MP0003656_abnormal_erythrocyte_physiolo0.52429546
175MP0001765_abnormal_ion_homeostasis0.52311504
176MP0002796_impaired_skin_barrier0.52113341
177MP0002092_abnormal_eye_morphology0.52059749
178MP0002078_abnormal_glucose_homeostasis0.51856892
179MP0002136_abnormal_kidney_physiology0.51207743
180MP0002006_tumorigenesis0.49419596
181MP0004087_abnormal_muscle_fiber0.49415308
182MP0002272_abnormal_nervous_system0.48300963
183MP0000462_abnormal_digestive_system0.47675821
184MP0003795_abnormal_bone_structure0.46954557

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)6.78873627
2Mesomelia (HP:0003027)5.64139667
3Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.29620847
4Short 1st metacarpal (HP:0010034)5.29620847
5Sensorimotor neuropathy (HP:0007141)5.07662149
6Abnormality of the phalanges of the 2nd finger (HP:0009541)4.89853296
7Cortical dysplasia (HP:0002539)4.68586502
8Abnormality of the 1st metacarpal (HP:0010009)4.62731721
9Humeroradial synostosis (HP:0003041)4.61155054
10Synostosis involving the elbow (HP:0003938)4.61155054
11Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.59194930
12Spastic diplegia (HP:0001264)4.40919849
13Abnormal pupillary function (HP:0007686)4.11639324
14Enlarged epiphyses (HP:0010580)4.06797278
15Genetic anticipation (HP:0003743)3.93458380
16Abnormality of the proximal phalanges of the hand (HP:0009834)3.90421188
17Radial bowing (HP:0002986)3.80485212
18Medial flaring of the eyebrow (HP:0010747)3.77655524
19Pancreatic cysts (HP:0001737)3.67943680
20Deformed tarsal bones (HP:0008119)3.66385841
21Nephronophthisis (HP:0000090)3.65973457
22Abnormality of the 2nd finger (HP:0004100)3.59724035
23Abnormality of midbrain morphology (HP:0002418)3.58962725
24Molar tooth sign on MRI (HP:0002419)3.58962725
25Gonadotropin excess (HP:0000837)3.42623207
26Attenuation of retinal blood vessels (HP:0007843)3.41051209
27Progressive cerebellar ataxia (HP:0002073)3.36915636
28Pancreatic fibrosis (HP:0100732)3.33229699
29Abnormality of the renal medulla (HP:0100957)3.31284443
30Type II lissencephaly (HP:0007260)3.31011739
31Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.28773717
32True hermaphroditism (HP:0010459)3.24380061
33Gaze-evoked nystagmus (HP:0000640)3.23504714
34Symphalangism affecting the phalanges of the hand (HP:0009773)3.22437067
35Gait imbalance (HP:0002141)3.21339348
36Short phalanx of the thumb (HP:0009660)3.18846184
372-3 toe syndactyly (HP:0004691)3.18322906
38Abnormality of the middle phalanges of the toes (HP:0010183)3.18269465
39Absent rod-and cone-mediated responses on ERG (HP:0007688)3.15481993
40Fibular hypoplasia (HP:0003038)3.14479480
41Congenital primary aphakia (HP:0007707)3.14038169
42Adactyly (HP:0009776)3.08409798
43Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.05072296
44Abnormal rod and cone electroretinograms (HP:0008323)3.02536622
45Abnormality of the renal cortex (HP:0011035)3.01292134
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.99777727
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.99444962
48Nephrogenic diabetes insipidus (HP:0009806)2.97933351
49Abnormality of fatty-acid metabolism (HP:0004359)2.94709523
50Bowed forearm bones (HP:0003956)2.93762445
51Bowing of the arm (HP:0006488)2.93762445
52Increased CSF protein (HP:0002922)2.92062134
53Hypoplastic ischia (HP:0003175)2.90061446
54Narrow nasal bridge (HP:0000446)2.85846449
55Tubulointerstitial nephritis (HP:0001970)2.85554522
56Short tibia (HP:0005736)2.83764147
57Ankyloglossia (HP:0010296)2.83736449
58Constricted visual fields (HP:0001133)2.76067100
59Cerebellar dysplasia (HP:0007033)2.74982696
60Aplasia/Hypoplasia of the fibula (HP:0006492)2.72226395
61Abnormality of the intrinsic pathway (HP:0010989)2.71190709
62Testicular atrophy (HP:0000029)2.71039302
63Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.70204505
64Focal motor seizures (HP:0011153)2.68978291
65Congenital stationary night blindness (HP:0007642)2.68072845
66Deep venous thrombosis (HP:0002625)2.64354396
67Right ventricular cardiomyopathy (HP:0011663)2.64266055
68Short hallux (HP:0010109)2.63711673
69Short metatarsal (HP:0010743)2.62739882
70Conjugated hyperbilirubinemia (HP:0002908)2.61927129
71Anosmia (HP:0000458)2.60441514
72Abolished electroretinogram (ERG) (HP:0000550)2.60211717
73Renal cortical cysts (HP:0000803)2.60093977
74Abnormality of macular pigmentation (HP:0008002)2.59964387
75Hypoplasia of the pons (HP:0012110)2.58517874
76Abnormality of the ischium (HP:0003174)2.56853996
77Aplasia/Hypoplasia of the hallux (HP:0008362)2.53246485
78Abnormality of the common coagulation pathway (HP:0010990)2.52936341
79Ketosis (HP:0001946)2.51621686
80Genital tract atresia (HP:0001827)2.48877323
81Hyperventilation (HP:0002883)2.47641308
82Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.45727904
83Cystic liver disease (HP:0006706)2.43021155
84Inability to walk (HP:0002540)2.42533107
85Congenital hepatic fibrosis (HP:0002612)2.41082076
86Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.40868391
87Chronic hepatic failure (HP:0100626)2.40773899
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39977738
89Vaginal atresia (HP:0000148)2.38290262
90Back pain (HP:0003418)2.34676941
91Abnormal drinking behavior (HP:0030082)2.32769250
92Polydipsia (HP:0001959)2.32769250
93Decreased central vision (HP:0007663)2.32241407
94Malnutrition (HP:0004395)2.32186478
95Abnormal protein N-linked glycosylation (HP:0012347)2.32162331
96Abnormal protein glycosylation (HP:0012346)2.32162331
97Abnormal glycosylation (HP:0012345)2.32162331
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32162331
99Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.31953153
100Generalized hypopigmentation of hair (HP:0011358)2.30325429
101Limb-girdle muscle atrophy (HP:0003797)2.29820576
102Hypsarrhythmia (HP:0002521)2.29211841
103Aplasia/Hypoplasia of the tibia (HP:0005772)2.28555879
104Retinal dysplasia (HP:0007973)2.27860868
105Intestinal atresia (HP:0011100)2.24536601
106Vascular calcification (HP:0004934)2.24108731
107Abnormality of the pons (HP:0007361)2.23688782
108Bile duct proliferation (HP:0001408)2.21494854
109Abnormal biliary tract physiology (HP:0012439)2.21494854
110Congenital sensorineural hearing impairment (HP:0008527)2.20637490
111Poor coordination (HP:0002370)2.18492582
112EEG with generalized epileptiform discharges (HP:0011198)2.17326774
113Cardiovascular calcification (HP:0011915)2.16298638
114Absent speech (HP:0001344)2.14732055
115Premature skin wrinkling (HP:0100678)2.14055037
116Focal seizures (HP:0007359)2.13104313
117Abnormal ciliary motility (HP:0012262)2.12429076
118Congenital glaucoma (HP:0001087)2.12224244
119Keratoconus (HP:0000563)2.11002987
120Increased corneal curvature (HP:0100692)2.11002987
121Abnormality of oral frenula (HP:0000190)2.10826096
122Drooling (HP:0002307)2.09451840
123Fragile skin (HP:0001030)2.09044310
124Epileptiform EEG discharges (HP:0011182)2.08846775
125Rimmed vacuoles (HP:0003805)2.07822830
126Dynein arm defect of respiratory motile cilia (HP:0012255)2.04524080
127Absent/shortened dynein arms (HP:0200106)2.04524080
128Short humerus (HP:0005792)2.02549993
129Postaxial hand polydactyly (HP:0001162)2.02031740
130Dyskinesia (HP:0100660)2.00985082
131Camptodactyly of toe (HP:0001836)2.00248163
132Dialeptic seizures (HP:0011146)2.00087554
133Hyperglycinuria (HP:0003108)1.98754961
134Short foot (HP:0001773)1.98465262
135Progressive inability to walk (HP:0002505)1.98462654
136Pachygyria (HP:0001302)1.97634446
137Lissencephaly (HP:0001339)1.97163181
138Postaxial foot polydactyly (HP:0001830)1.96738088
139Thyroid-stimulating hormone excess (HP:0002925)1.96409041
140Cerebral inclusion bodies (HP:0100314)1.96320467
141Bony spicule pigmentary retinopathy (HP:0007737)1.96064990
142Febrile seizures (HP:0002373)1.95870101
143Neonatal respiratory distress (HP:0002643)1.95815516
144Ketoacidosis (HP:0001993)1.95782842
145Lip pit (HP:0100267)1.95701739
146Specific learning disability (HP:0001328)1.95226931
147Cardiomegaly (HP:0001640)1.94840638
148Visual hallucinations (HP:0002367)1.92368693
149Retinitis pigmentosa (HP:0000510)1.91873420
150Abnormal respiratory motile cilium morphology (HP:0005938)1.88600423
151Abnormal respiratory epithelium morphology (HP:0012253)1.88600423
152Hemiparesis (HP:0001269)1.88547763
153Abnormality of glycine metabolism (HP:0010895)1.88503823
154Abnormality of serine family amino acid metabolism (HP:0010894)1.88503823
155Tubulointerstitial abnormality (HP:0001969)1.87890535
156Hyperglycinemia (HP:0002154)1.87737006
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.86480326
158Excessive salivation (HP:0003781)1.85327537
159Calf muscle hypertrophy (HP:0008981)1.83667518
160Broad-based gait (HP:0002136)1.83155808
161Polyuria (HP:0000103)1.81945479
162Sclerocornea (HP:0000647)1.81926157
163Abnormality of the labia minora (HP:0012880)1.81837089
164Abnormal respiratory motile cilium physiology (HP:0012261)1.80851582
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79479214
166Metaphyseal dysplasia (HP:0100255)1.78494313
167Femoral bowing (HP:0002980)1.77581123
168Polymicrogyria (HP:0002126)1.76622018
169Polyphagia (HP:0002591)1.75241566
170Rhizomelia (HP:0008905)1.75043136
171Abdominal distention (HP:0003270)1.74540925
172Astigmatism (HP:0000483)1.74172068
173Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.73768740
174Tubular atrophy (HP:0000092)1.73678215
175Intrahepatic cholestasis (HP:0001406)1.72706148
176Protuberant abdomen (HP:0001538)1.72646664
177Aplasia/hypoplasia of the humerus (HP:0006507)1.72106645
178Wrist flexion contracture (HP:0001239)1.71648698
179Aplasia/Hypoplasia of the uvula (HP:0010293)1.70138872
180Widely spaced teeth (HP:0000687)1.69963720
181Hypoplastic iliac wings (HP:0002866)1.69939373
182Rectal prolapse (HP:0002035)1.69932124
183Hypoplasia of the iris (HP:0007676)1.66703948
184Broad hallux (HP:0010055)1.63591529
185Muscle hypertrophy of the lower extremities (HP:0008968)1.61691533
186Stillbirth (HP:0003826)1.60072512
187Abnormality of monocarboxylic acid metabolism (HP:0010996)1.59889045
188Insidious onset (HP:0003587)1.59108925
189Termporal pattern (HP:0011008)1.59108925
190J-shaped sella turcica (HP:0002680)1.58614660
191Xanthomatosis (HP:0000991)1.58151465
192Wide nose (HP:0000445)1.54634270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.68023787
2MAP4K23.55272258
3ERN13.53824688
4LATS13.37890615
5IRAK33.20592853
6PINK12.98466200
7FER2.90766881
8PDK42.82584702
9PDK32.82584702
10TNK22.80818691
11STK392.61661704
12STK38L2.58198432
13MAPK132.41891805
14TAOK32.40381061
15MAP2K42.31921779
16MAP3K92.21366799
17MAP3K42.13026573
18ADRBK22.12475534
19WNK42.10702367
20BMPR1B2.08223166
21TRIM281.96585760
22WNK31.94633808
23TRIB31.91513725
24EEF2K1.77487298
25NUAK11.76008609
26ZAK1.70924417
27NME21.68263948
28PIK3CA1.60759462
29PLK41.50699429
30PDK21.49682410
31OXSR11.49547532
32EPHB11.45068438
33PKN21.40236541
34CASK1.39770583
35MAP2K71.36196593
36GRK11.30951888
37CSNK1G11.26877354
38PRKD31.25639564
39FRK1.25419511
40HIPK21.24900327
41CSNK1A1L1.24893166
42PTK61.24799557
43NTRK11.23850506
44RET1.23411051
45MAP3K21.21907596
46CAMKK21.19494826
47PRKCE1.15537582
48NTRK31.14066932
49UHMK11.13899883
50MST1R1.10109263
51MAP3K61.07242799
52CSNK1G31.05938163
53LATS21.01944068
54CSNK1G21.01840398
55DYRK21.01256411
56MAP3K70.99769245
57MET0.96754954
58KIT0.95510281
59BMX0.94518739
60CCNB10.94348137
61SCYL20.94150492
62PRKCG0.93395578
63EIF2AK30.93303557
64WNK10.90134830
65SIK20.88615480
66KSR20.83202154
67ACVR1B0.82745045
68PLK20.82181171
69ADRBK10.79962978
70ERBB30.77934010
71IRAK20.77692454
72PAK30.76782077
73RPS6KB20.74910343
74PTK2B0.73610040
75EPHA30.73355601
76INSRR0.72973681
77LRRK20.70883112
78IRAK40.67069312
79CAMK2A0.65927523
80TTN0.65710771
81PDGFRA0.65199843
82RIPK10.64046870
83DDR20.63640877
84CDK50.61418913
85EPHA40.60413495
86CSNK1D0.58985867
87DYRK30.58422002
88PAK60.58155523
89NTRK20.57967259
90STK380.57171760
91MAP2K30.57088482
92GRK60.56710737
93IRAK10.54447167
94PRKAA10.54364635
95PTK20.54236343
96PRKCZ0.53616036
97SGK20.52820906
98BRSK20.52635044
99MINK10.52341639
100CAMK40.52330527
101SRPK10.51995702
102RPS6KA50.51323696
103MAP2K60.50861516
104PDPK10.50811632
105BLK0.50623413
106TAOK10.50218382
107DAPK20.49756993
108PRKACA0.48891516
109PRKD10.48677874
110MAP3K50.48080200
111PRKG10.47879421
112DYRK1A0.47810034
113ERBB20.47682865
114TIE10.47120376
115PDK10.46601701
116FGFR40.46167175
117OBSCN0.45894838
118MAP3K100.44979803
119PRKAA20.44615793
120SIK10.44396111
121SGK4940.43956241
122SGK2230.43956241
123PAK20.43952770
124MAPK120.43464303
125TGFBR10.41928725
126CSNK1A10.41820994
127NLK0.41054705
128ALK0.40136713
129FLT30.40096393
130MTOR0.39501685
131PIK3CG0.39490136
132CAMK10.39221121
133AKT30.38102311
134FYN0.37424843
135CDK30.37334499
136TEC0.35791393
137ATM0.35750226
138CSNK1E0.35557992
139PRKACB0.35043331
140FES0.34945677
141JAK20.34707645
142RPS6KB10.34366995
143STK110.34170378
144MATK0.34072157
145FGR0.33676797
146MKNK20.33036869
147TRPM70.32303451
148CDK190.29869255
149PRKCH0.29437863
150PKN10.28827537
151STK30.28760530
152MARK10.28478835
153LMTK20.26566464
154SRC0.25183693
155JAK10.23762123
156MAP2K10.23054775
157CAMKK10.22777482
158CDK60.21988765
159RPS6KA30.20864192
160BCR0.20762612
161ROCK20.20572276
162PDGFRB0.19327445
163CDC42BPA0.18045804
164PHKG20.17513839
165PHKG10.17513839
166CAMK2D0.17033263

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.66590284
2Salivary secretion_Homo sapiens_hsa049704.35185520
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.19178934
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.94464817
5Nicotine addiction_Homo sapiens_hsa050332.96298758
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.91083806
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.79176690
8Propanoate metabolism_Homo sapiens_hsa006402.72470001
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.70416415
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.34844976
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16784015
12Phototransduction_Homo sapiens_hsa047442.16380447
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13969886
14Sulfur metabolism_Homo sapiens_hsa009201.95956612
15Fatty acid degradation_Homo sapiens_hsa000711.95263283
16Nitrogen metabolism_Homo sapiens_hsa009101.89922114
17Linoleic acid metabolism_Homo sapiens_hsa005911.86833697
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74922911
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73652857
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71468077
21Pyruvate metabolism_Homo sapiens_hsa006201.68582723
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61480651
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60120998
24beta-Alanine metabolism_Homo sapiens_hsa004101.58560256
25Regulation of autophagy_Homo sapiens_hsa041401.58011867
26Arginine biosynthesis_Homo sapiens_hsa002201.54594855
27Olfactory transduction_Homo sapiens_hsa047401.52852605
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.49709958
29Retinol metabolism_Homo sapiens_hsa008301.47710351
30Peroxisome_Homo sapiens_hsa041461.44622217
31Steroid biosynthesis_Homo sapiens_hsa001001.41964865
32Selenocompound metabolism_Homo sapiens_hsa004501.37465802
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36609673
34Histidine metabolism_Homo sapiens_hsa003401.35588883
35Tryptophan metabolism_Homo sapiens_hsa003801.30929564
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24818773
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23891972
38Butanoate metabolism_Homo sapiens_hsa006501.23275640
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14457578
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13735478
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13042313
42Fanconi anemia pathway_Homo sapiens_hsa034601.12956803
43Ether lipid metabolism_Homo sapiens_hsa005651.12733212
44Serotonergic synapse_Homo sapiens_hsa047261.08902739
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05247465
46Caffeine metabolism_Homo sapiens_hsa002321.02276702
47N-Glycan biosynthesis_Homo sapiens_hsa005101.01751096
48Circadian rhythm_Homo sapiens_hsa047101.01392905
49Bile secretion_Homo sapiens_hsa049761.01268126
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96908860
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96618913
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96138298
53Basal transcription factors_Homo sapiens_hsa030220.95582328
54Biosynthesis of amino acids_Homo sapiens_hsa012300.94017171
55Fatty acid metabolism_Homo sapiens_hsa012120.92999156
56Carbon metabolism_Homo sapiens_hsa012000.88820479
57Type I diabetes mellitus_Homo sapiens_hsa049400.88470957
58Arginine and proline metabolism_Homo sapiens_hsa003300.86941459
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80809766
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80040444
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79202247
62RNA polymerase_Homo sapiens_hsa030200.78297019
63Non-homologous end-joining_Homo sapiens_hsa034500.78153102
64Insulin secretion_Homo sapiens_hsa049110.77470622
65Long-term potentiation_Homo sapiens_hsa047200.72529193
66Lysine degradation_Homo sapiens_hsa003100.69709378
67Arachidonic acid metabolism_Homo sapiens_hsa005900.69275280
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.67294412
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64823498
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64746283
71PPAR signaling pathway_Homo sapiens_hsa033200.64628772
72Thyroid hormone synthesis_Homo sapiens_hsa049180.63732265
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63229149
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61559616
75Dopaminergic synapse_Homo sapiens_hsa047280.61144306
76Insulin resistance_Homo sapiens_hsa049310.59904617
77Estrogen signaling pathway_Homo sapiens_hsa049150.59760557
78Gastric acid secretion_Homo sapiens_hsa049710.59181492
79GABAergic synapse_Homo sapiens_hsa047270.58730682
80Pancreatic secretion_Homo sapiens_hsa049720.58436124
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58346381
82Vibrio cholerae infection_Homo sapiens_hsa051100.58256232
83Folate biosynthesis_Homo sapiens_hsa007900.58039889
84Glycerolipid metabolism_Homo sapiens_hsa005610.57990660
85Cholinergic synapse_Homo sapiens_hsa047250.57517089
86Fatty acid biosynthesis_Homo sapiens_hsa000610.56890184
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56770300
88Homologous recombination_Homo sapiens_hsa034400.56210716
89Calcium signaling pathway_Homo sapiens_hsa040200.53305432
90Type II diabetes mellitus_Homo sapiens_hsa049300.53151228
91Synaptic vesicle cycle_Homo sapiens_hsa047210.53048907
92Metabolic pathways_Homo sapiens_hsa011000.51771523
93Amphetamine addiction_Homo sapiens_hsa050310.51516995
94Complement and coagulation cascades_Homo sapiens_hsa046100.50789750
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50759638
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50532894
97Long-term depression_Homo sapiens_hsa047300.50323704
98Chemical carcinogenesis_Homo sapiens_hsa052040.49104118
99Renin secretion_Homo sapiens_hsa049240.48913394
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.48628993
101Asthma_Homo sapiens_hsa053100.47718810
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46461504
103Glucagon signaling pathway_Homo sapiens_hsa049220.45269529
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45118249
105Cocaine addiction_Homo sapiens_hsa050300.44320044
106Ovarian steroidogenesis_Homo sapiens_hsa049130.43361151
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.42442512
108Circadian entrainment_Homo sapiens_hsa047130.41912972
109Glutamatergic synapse_Homo sapiens_hsa047240.41772914
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41064575
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.39347063
112Fatty acid elongation_Homo sapiens_hsa000620.39213295
113Collecting duct acid secretion_Homo sapiens_hsa049660.39108651
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38558235
115Sphingolipid metabolism_Homo sapiens_hsa006000.37578102
116GnRH signaling pathway_Homo sapiens_hsa049120.35846135
117Lysosome_Homo sapiens_hsa041420.35248263
118RNA degradation_Homo sapiens_hsa030180.34939018
119mTOR signaling pathway_Homo sapiens_hsa041500.34875353
120ErbB signaling pathway_Homo sapiens_hsa040120.34477943
121Tyrosine metabolism_Homo sapiens_hsa003500.34147360
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33058013
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32991453
124Starch and sucrose metabolism_Homo sapiens_hsa005000.32056576
125Base excision repair_Homo sapiens_hsa034100.31407623
126ABC transporters_Homo sapiens_hsa020100.31142561
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30835513
128Melanogenesis_Homo sapiens_hsa049160.30769719
129Phenylalanine metabolism_Homo sapiens_hsa003600.29707997
130Vitamin digestion and absorption_Homo sapiens_hsa049770.29304612
131Mineral absorption_Homo sapiens_hsa049780.28066217
132Purine metabolism_Homo sapiens_hsa002300.27712500
133Morphine addiction_Homo sapiens_hsa050320.27537432
134Tight junction_Homo sapiens_hsa045300.27412527
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27102015
136One carbon pool by folate_Homo sapiens_hsa006700.26487555
137cAMP signaling pathway_Homo sapiens_hsa040240.25753455
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.25209585
139Pertussis_Homo sapiens_hsa051330.25176702
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.25123950
141Glioma_Homo sapiens_hsa052140.25009310
142Hepatitis C_Homo sapiens_hsa051600.24740460
143Fat digestion and absorption_Homo sapiens_hsa049750.22074191
144Fructose and mannose metabolism_Homo sapiens_hsa000510.20765825
145Taste transduction_Homo sapiens_hsa047420.19911608
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19591020
147Gap junction_Homo sapiens_hsa045400.18799039

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