SCGB3A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)9.88393733
2regulation of posttranscriptional gene silencing (GO:0060147)9.88393733
3regulation of gene silencing by miRNA (GO:0060964)9.88393733
4chemical homeostasis within a tissue (GO:0048875)9.24175921
5pre-miRNA processing (GO:0031054)6.84234162
6positive regulation of SMAD protein import into nucleus (GO:0060391)6.40125092
7regulation of interleukin-13 production (GO:0032656)6.11188199
8paraxial mesoderm development (GO:0048339)5.39532359
9dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.35256842
10positive regulation of endothelial cell differentiation (GO:0045603)5.32133411
11motile cilium assembly (GO:0044458)5.10548806
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.06946980
13negative regulation of translation, ncRNA-mediated (GO:0040033)5.06946980
14regulation of translation, ncRNA-mediated (GO:0045974)5.06946980
15regulation of gene silencing (GO:0060968)5.03655922
16regulation of cell fate specification (GO:0042659)4.98776451
17regulation of interleukin-5 production (GO:0032674)4.88087667
18regulation of vasculogenesis (GO:2001212)4.82655674
19regulation of tight junction assembly (GO:2000810)4.78749278
20regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.77537327
21positive regulation of vasculogenesis (GO:2001214)4.69792299
22lung-associated mesenchyme development (GO:0060484)4.68517695
23negative regulation of gene silencing (GO:0060969)4.66656091
24establishment of integrated proviral latency (GO:0075713)4.60663673
25regulation of SMAD protein import into nucleus (GO:0060390)4.56829262
26regulation of endothelial cell differentiation (GO:0045601)4.54848875
27regulation of histone H3-K9 methylation (GO:0051570)4.54785638
28regulation of chromatin silencing (GO:0031935)4.46995858
29sodium ion homeostasis (GO:0055078)4.46398468
30heterochromatin organization (GO:0070828)4.46306002
31protein complex localization (GO:0031503)4.45539459
32negative regulation of androgen receptor signaling pathway (GO:0060766)4.41045376
33negative regulation of systemic arterial blood pressure (GO:0003085)4.29385499
34induction of positive chemotaxis (GO:0050930)4.28461647
35positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.22667203
36negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.17788456
37cell fate commitment involved in formation of primary germ layer (GO:0060795)4.16907479
38morphogenesis of an endothelium (GO:0003159)4.16673943
39endothelial tube morphogenesis (GO:0061154)4.16673943
40positive regulation of positive chemotaxis (GO:0050927)4.11309956
41lung vasculature development (GO:0060426)4.07641406
42protein localization to kinetochore (GO:0034501)3.98749068
43nodal signaling pathway (GO:0038092)3.97724623
44L-alpha-amino acid transmembrane transport (GO:1902475)3.97586425
45fibroblast migration (GO:0010761)3.96772809
46nuclear pore complex assembly (GO:0051292)3.89903731
47regulation of positive chemotaxis (GO:0050926)3.88929234
48regulation of hippo signaling (GO:0035330)3.88270503
49lymph vessel development (GO:0001945)3.88264892
50negative regulation of histone methylation (GO:0031061)3.85953242
51establishment of apical/basal cell polarity (GO:0035089)3.83244730
52L-serine metabolic process (GO:0006563)3.81791434
53positive regulation of catenin import into nucleus (GO:0035413)3.80890977
54lung lobe morphogenesis (GO:0060463)3.75097567
55phenylpropanoid metabolic process (GO:0009698)3.72250219
56blood vessel maturation (GO:0001955)3.70323246
57cellular response to nitric oxide (GO:0071732)3.69999701
58regulation of stem cell maintenance (GO:2000036)3.65736546
59negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.63534976
60one-carbon compound transport (GO:0019755)3.63040237
61regulation of cell fate commitment (GO:0010453)3.62370592
62regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.60718400
63histone arginine methylation (GO:0034969)3.59915030
64notochord development (GO:0030903)3.58800054
65anterior/posterior axis specification, embryo (GO:0008595)3.54038548
66polyketide metabolic process (GO:0030638)3.51652772
67doxorubicin metabolic process (GO:0044598)3.51652772
68daunorubicin metabolic process (GO:0044597)3.51652772
69nuclear pore organization (GO:0006999)3.49387436
70glomerular visceral epithelial cell development (GO:0072015)3.47741138
71negative regulation of response to reactive oxygen species (GO:1901032)3.47734986
72regulation of helicase activity (GO:0051095)3.47541047
73wound healing, spreading of epidermal cells (GO:0035313)3.47488841
74xenobiotic catabolic process (GO:0042178)3.43887775
75negative regulation of glycoprotein biosynthetic process (GO:0010561)3.42085634
76regulation of DNA methylation (GO:0044030)3.39132988
77peptide catabolic process (GO:0043171)3.35377471
78lateral ventricle development (GO:0021670)3.34820926
79hyperosmotic salinity response (GO:0042538)3.34022831
80protein autoprocessing (GO:0016540)3.33154564
81epithelial cell differentiation involved in prostate gland development (GO:0060742)3.32882425
82establishment or maintenance of monopolar cell polarity (GO:0061339)3.29337205
83establishment of monopolar cell polarity (GO:0061162)3.29337205
84centriole assembly (GO:0098534)3.25705256
85single strand break repair (GO:0000012)3.24463173
86positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.24305730
87positive regulation of cell cycle G2/M phase transition (GO:1902751)3.24305730
88virion attachment to host cell (GO:0019062)3.23766824
89adhesion of symbiont to host cell (GO:0044650)3.23766824
90ethanol oxidation (GO:0006069)3.23401260
91regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.23396037
92water homeostasis (GO:0030104)3.21197107
93protein localization to chromosome, centromeric region (GO:0071459)3.20902349
94lysine metabolic process (GO:0006553)3.18648098
95lysine catabolic process (GO:0006554)3.18648098
96epithelial tube branching involved in lung morphogenesis (GO:0060441)3.18645375
97wound healing, spreading of cells (GO:0044319)3.17826039
98smooth muscle tissue development (GO:0048745)3.16025108
99aminoglycoside antibiotic metabolic process (GO:0030647)3.14435695
100negative regulation of sodium ion transport (GO:0010766)3.13796417
101DNA unwinding involved in DNA replication (GO:0006268)3.12705764
102negative regulation of cell fate specification (GO:0009996)3.10846547
103cellular protein complex localization (GO:0034629)3.09841258
104establishment of viral latency (GO:0019043)3.07402910
105negative regulation of cell fate commitment (GO:0010454)3.06296422
106regulation of interleukin-4 production (GO:0032673)3.06110863
107negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.05338886
108endocardial cushion development (GO:0003197)3.02471327
109glomerular epithelial cell development (GO:0072310)3.01752533
110ethanol metabolic process (GO:0006067)3.01202773
111multicellular organismal water homeostasis (GO:0050891)2.98479789
112respiratory tube development (GO:0030323)2.95024056
113hippo signaling (GO:0035329)2.94943778
114lymphangiogenesis (GO:0001946)2.94079711
115intestinal cholesterol absorption (GO:0030299)2.93876236
116positive regulation of p38MAPK cascade (GO:1900745)2.92721824
117blood vessel remodeling (GO:0001974)2.90584957
118negative regulation of transcription by competitive promoter binding (GO:0010944)2.89315476
119mitotic sister chromatid cohesion (GO:0007064)2.88142405
120regulation of mesoderm development (GO:2000380)2.87796286
121calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.86379389
122gas transport (GO:0015669)2.85525877
123regulation of integrin-mediated signaling pathway (GO:2001044)2.84820614
124negative regulation of epithelial to mesenchymal transition (GO:0010719)2.83005475
125monoubiquitinated protein deubiquitination (GO:0035520)2.82931396
126lateral sprouting from an epithelium (GO:0060601)2.81963599
127convergent extension (GO:0060026)2.81932031
128nucleotide-sugar biosynthetic process (GO:0009226)2.79801801
129negative regulation of interferon-gamma production (GO:0032689)2.79074285
130respiratory gaseous exchange (GO:0007585)2.77780534
131cilium or flagellum-dependent cell motility (GO:0001539)2.75832505
132cell migration involved in gastrulation (GO:0042074)2.74278599
133IMP biosynthetic process (GO:0006188)2.74043612
134negative regulation of chromosome segregation (GO:0051985)2.73171283
135negative regulation of T cell proliferation (GO:0042130)2.72985308
136response to nitric oxide (GO:0071731)2.72630480
137planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72569688
138atrioventricular valve morphogenesis (GO:0003181)2.72081894
139cyclooxygenase pathway (GO:0019371)2.72036945
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71276994
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71276994
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71276994
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.71276994
144negative regulation of sister chromatid segregation (GO:0033046)2.71276994
145negative regulation of potassium ion transmembrane transport (GO:1901380)2.71118652
146IMP metabolic process (GO:0046040)2.70487164
147adhesion of symbiont to host (GO:0044406)2.70092328
148cell adhesion mediated by integrin (GO:0033627)2.69985930
149hepatocyte apoptotic process (GO:0097284)2.68814744
150adaptation of signaling pathway (GO:0023058)2.68513347
151negative regulation of keratinocyte proliferation (GO:0010839)2.67970962
152positive regulation of chromosome segregation (GO:0051984)2.66801016
153establishment of endothelial barrier (GO:0061028)2.66144043
154positive regulation of blood coagulation (GO:0030194)2.65718964
155positive regulation of hemostasis (GO:1900048)2.65718964
156mesodermal cell differentiation (GO:0048333)2.65607786
157response to nitrosative stress (GO:0051409)2.65411352
158positive regulation of wound healing (GO:0090303)2.64863223
159prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.64817665
160glutathione derivative metabolic process (GO:1901685)2.64250530
161glutathione derivative biosynthetic process (GO:1901687)2.64250530
162negative regulation of glycoprotein metabolic process (GO:1903019)2.63112243
163cellular sodium ion homeostasis (GO:0006883)2.59708942
164postsynaptic membrane organization (GO:0001941)2.58953471
165Leydig cell differentiation (GO:0033327)2.58465490
166blastocyst development (GO:0001824)2.58214872
167tight junction assembly (GO:0070830)2.58062957
168bundle of His cell to Purkinje myocyte communication (GO:0086069)2.57825507
169cellular response to reactive nitrogen species (GO:1902170)2.57034287
170generation of neurons (GO:0048699)2.56925705
171histone H3-K36 demethylation (GO:0070544)2.56627041
172regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56447539
173regulation of catenin import into nucleus (GO:0035412)2.56348382
174negative regulation of protein localization to cell surface (GO:2000009)2.56113165
175cell migration involved in sprouting angiogenesis (GO:0002042)2.55936129
176regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.55587036
177nucleosome disassembly (GO:0006337)2.54960793
178protein-DNA complex disassembly (GO:0032986)2.54960793
179axonemal dynein complex assembly (GO:0070286)2.54254372
180mitotic metaphase plate congression (GO:0007080)2.53643367
181lung alveolus development (GO:0048286)2.53122122
182positive regulation of Rho protein signal transduction (GO:0035025)2.51374910
183kidney morphogenesis (GO:0060993)2.51062411
184ncRNA catabolic process (GO:0034661)2.50167729
185pore complex assembly (GO:0046931)2.49942105
186regulation of chromosome segregation (GO:0051983)2.49776953
187retinal cone cell development (GO:0046549)2.49604857
188renal filtration (GO:0097205)2.48697596
189embryo implantation (GO:0007566)2.48634127
190peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.48180939
191cellular response to thyroid hormone stimulus (GO:0097067)2.47264118
192regulation of relaxation of muscle (GO:1901077)2.43201652
193response to xenobiotic stimulus (GO:0009410)11.7047039
194surfactant homeostasis (GO:0043129)11.4914123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03175957
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.03733290
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.03733290
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.03733290
5GATA1_22025678_ChIP-Seq_K562_Human4.37255140
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.11712043
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.90771997
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.62775179
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.54623531
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.15109517
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.12420711
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.98920768
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.92914487
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.91715443
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.85962143
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.72741157
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.65863534
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64839407
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.50012803
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.46684451
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36888514
22CLOCK_20551151_ChIP-Seq_293T_Human2.35964615
23CDX2_20551321_ChIP-Seq_CACO-2_Human2.32729222
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.31705342
25TCF3_18692474_ChIP-Seq_MESCs_Mouse2.30864993
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.29104272
27ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25844850
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24176740
29* NANOG_16153702_ChIP-ChIP_HESCs_Human2.16019465
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15459895
31ESR2_21235772_ChIP-Seq_MCF-7_Human2.14419735
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13502691
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12968029
34SOX2_16153702_ChIP-ChIP_HESCs_Human2.10196465
35TP53_18474530_ChIP-ChIP_U2OS_Human2.08464754
36E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04164485
37SOX2_27498859_Chip-Seq_STOMACH_Mouse2.02704892
38POU5F1_16153702_ChIP-ChIP_HESCs_Human2.01563039
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94035662
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.92065862
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.86966776
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.83283254
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81919819
44SOX2_20726797_ChIP-Seq_SW620_Human1.79687848
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79542123
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79228803
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77570476
48AHR_22903824_ChIP-Seq_MCF-7_Human1.76727527
49NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.74739310
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.73889601
51AR_21909140_ChIP-Seq_LNCAP_Human1.71752199
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68686261
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65921000
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.65448251
55PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.63432622
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63188619
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63188619
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62415810
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.61653168
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60562166
61NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.55665045
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55572618
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55097340
64SMAD3_21741376_ChIP-Seq_HESCs_Human1.55036522
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54541599
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54541599
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54343845
68TBX3_20139965_ChIP-Seq_ESCs_Mouse1.54122651
69POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.53375671
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53049903
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52991903
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.52126649
73TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.49425919
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49151223
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47447413
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40080907
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39844727
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.39746612
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37241313
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35675764
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.34458945
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34013519
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34013519
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.33933565
85NANOG_18692474_ChIP-Seq_MESCs_Mouse1.33246210
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.33103623
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.31202343
88NANOG_16518401_ChIP-PET_MESCs_Mouse1.30999000
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.29940117
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29787216
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.29657410
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29232000
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.27893872
94RACK7_27058665_Chip-Seq_MCF-7_Human1.26791136
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25842660
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25624469
97CJUN_26792858_Chip-Seq_BT549_Human1.25544206
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.23402573
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.23402573
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23093847
101NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22129656
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21428878
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21094463
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19540273
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19207343
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18444053
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18196907
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18146712
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17624120
110P300_19829295_ChIP-Seq_ESCs_Human1.17387538
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17307857
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.17153570
113VDR_24787735_ChIP-Seq_THP-1_Human1.17045756
114TP63_17297297_ChIP-ChIP_HaCaT_Human1.16518083
115GATA1_19941826_ChIP-Seq_K562_Human1.16253011
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15902586
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15766694
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15294752
119RXR_22108803_ChIP-Seq_LS180_Human1.15289863
120BCAT_22108803_ChIP-Seq_LS180_Human1.14549471
121SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14129943
122SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13918392
123SMAD4_21741376_ChIP-Seq_HESCs_Human1.13811259
124ZNF274_21170338_ChIP-Seq_K562_Hela1.13042276
125FUS_26573619_Chip-Seq_HEK293_Human1.12704941
126MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12523563
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12429566
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11855594
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11237811
130TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10868294
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09732631
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09573493
133GATA4_25053715_ChIP-Seq_YYC3_Human1.09100600
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08742333
135STAT3_18555785_ChIP-Seq_MESCs_Mouse1.08672128
136POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07625824
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06816592
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06340563
139PIAS1_25552417_ChIP-Seq_VCAP_Human1.05979868
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05701226
141KAP1_27257070_Chip-Seq_ESCs_Mouse1.05281849
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04593118
143SMAD3_21741376_ChIP-Seq_ESCs_Human1.03478331
144ISL1_27105846_Chip-Seq_CPCs_Mouse1.03087304
145MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02843394
146ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02781277
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02382390
148VDR_22108803_ChIP-Seq_LS180_Human1.02247830
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00307830
150WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00173569
151EWS_26573619_Chip-Seq_HEK293_Human0.99657547
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98470067
153STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96392028
154NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95814418
155GATA3_24758297_ChIP-Seq_MCF-7_Human0.95425994
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94486752
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93422902
158SMAD_19615063_ChIP-ChIP_OVARY_Human0.92862346
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92816190
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92739945
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92352504
162NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91694918
163KLF5_25053715_ChIP-Seq_YYC3_Human0.91642169
164SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90831531
165CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90173571
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89961554
167AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89763373
168ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89666234
169FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88888427
170PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87701677
171MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87601341
172FOXA2_19822575_ChIP-Seq_HepG2_Human0.87339606
173YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87044452
174FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86946991
175TP63_23658742_ChIP-Seq_EP156T_Human0.86668793
176FOXA1_25552417_ChIP-Seq_VCAP_Human0.86421316
177WT1_19549856_ChIP-ChIP_CCG9911_Human0.85715910
178DROSHA_22980978_ChIP-Seq_HELA_Human0.85627285
179GATA2_19941826_ChIP-Seq_K562_Human0.85182594
180EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83976485
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83826009
182POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83534945
183POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83410568
184IRF1_19129219_ChIP-ChIP_H3396_Human0.82246132
185FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82112035
186E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81763389
187SMAD3_21741376_ChIP-Seq_EPCs_Human0.79613507
188AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78099350
189* AR_21572438_ChIP-Seq_LNCaP_Human0.77940484
190HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77692787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.59945888
2MP0004782_abnormal_surfactant_physiolog5.54940487
3MP0002132_abnormal_respiratory_system5.33268694
4MP0008875_abnormal_xenobiotic_pharmacok4.57034783
5MP0003941_abnormal_skin_development4.28763042
6MP0003890_abnormal_embryonic-extraembry4.16765887
7MP0005083_abnormal_biliary_tract3.92350926
8MP0001958_emphysema3.91499152
9MP0002277_abnormal_respiratory_mucosa3.71151271
10MP0003191_abnormal_cellular_cholesterol3.69039192
11MP0008057_abnormal_DNA_replication3.66214449
12MP0008995_early_reproductive_senescence3.47476997
13MP0010368_abnormal_lymphatic_system3.27043870
14MP0004957_abnormal_blastocyst_morpholog3.14699336
15MP0001879_abnormal_lymphatic_vessel2.90864270
16MP0003693_abnormal_embryo_hatching2.89225348
17MP0003718_maternal_effect2.81077835
18MP0002138_abnormal_hepatobiliary_system2.65880688
19MP0010352_gastrointestinal_tract_polyps2.53394000
20MP0008961_abnormal_basal_metabolism2.52342044
21MP0005167_abnormal_blood-brain_barrier2.35442826
22MP0009672_abnormal_birth_weight2.31178543
23MP0002139_abnormal_hepatobiliary_system2.28962284
24MP0004272_abnormal_basement_membrane2.24931283
25MP0004133_heterotaxia2.20504493
26MP0001730_embryonic_growth_arrest2.16415372
27MP0008932_abnormal_embryonic_tissue2.12292988
28MP0002133_abnormal_respiratory_system2.09398498
29MP0005388_respiratory_system_phenotype2.09398498
30MP0005408_hypopigmentation2.08924814
31MP0003111_abnormal_nucleus_morphology2.08369912
32MP0003136_yellow_coat_color2.06185961
33MP0008877_abnormal_DNA_methylation2.02382949
34MP0009764_decreased_sensitivity_to2.01671533
35MP0010030_abnormal_orbit_morphology1.97927461
36MP0003724_increased_susceptibility_to1.92647744
37MP0001177_atelectasis1.91957451
38MP0003937_abnormal_limbs/digits/tail_de1.91857038
39MP0005377_hearing/vestibular/ear_phenot1.89030093
40MP0003878_abnormal_ear_physiology1.89030093
41MP0009379_abnormal_foot_pigmentation1.87135793
42MP0002084_abnormal_developmental_patter1.84745355
43MP0003567_abnormal_fetal_cardiomyocyte1.82911978
44MP0002085_abnormal_embryonic_tissue1.78967448
45MP0004883_abnormal_blood_vessel1.78578850
46MP0010094_abnormal_chromosome_stability1.76824885
47MP0005085_abnormal_gallbladder_physiolo1.75005154
48MP0001672_abnormal_embryogenesis/_devel1.74801688
49MP0005380_embryogenesis_phenotype1.74801688
50MP0005367_renal/urinary_system_phenotyp1.71791024
51MP0000516_abnormal_urinary_system1.71791024
52MP0003566_abnormal_cell_adhesion1.70431263
53MP0000537_abnormal_urethra_morphology1.69414125
54MP0002295_abnormal_pulmonary_circulatio1.68253453
55MP0003077_abnormal_cell_cycle1.63061894
56MP0002697_abnormal_eye_size1.60901611
57MP0008004_abnormal_stomach_pH1.51689133
58MP0003984_embryonic_growth_retardation1.51574398
59MP0003828_pulmonary_edema1.47322467
60MP0003091_abnormal_cell_migration1.46211483
61MP0002088_abnormal_embryonic_growth/wei1.46150665
62MP0009780_abnormal_chondrocyte_physiolo1.42780426
63MP0000566_synostosis1.42358874
64MP0005164_abnormal_response_to1.42162316
65MP0010234_abnormal_vibrissa_follicle1.41190147
66MP0004043_abnormal_pH_regulation1.39455049
67MP0001293_anophthalmia1.39247613
68MP0008058_abnormal_DNA_repair1.38931945
69MP0006292_abnormal_olfactory_placode1.34300719
70MP0002909_abnormal_adrenal_gland1.33670402
71MP0005166_decreased_susceptibility_to1.29432715
72MP0001697_abnormal_embryo_size1.26962182
73MP0009703_decreased_birth_body1.26699526
74MP0004197_abnormal_fetal_growth/weight/1.25133365
75MP0000350_abnormal_cell_proliferation1.24108312
76MP0001346_abnormal_lacrimal_gland1.22501076
77MP0002080_prenatal_lethality1.20015625
78MP0003705_abnormal_hypodermis_morpholog1.19115692
79MP0000462_abnormal_digestive_system1.18726821
80MP0002796_impaired_skin_barrier1.18285462
81MP0002086_abnormal_extraembryonic_tissu1.18168541
82MP0003329_amyloid_beta_deposits1.18138406
83MP0001286_abnormal_eye_development1.15689182
84MP0010329_abnormal_lipoprotein_level1.15386357
85MP0002111_abnormal_tail_morphology1.13290944
86MP0003075_altered_response_to1.12667309
87MP0003300_gastrointestinal_ulcer1.12554798
88MP0004484_altered_response_of1.12194922
89MP0001849_ear_inflammation1.10938397
90MP0005595_abnormal_vascular_smooth1.10846944
91MP0001661_extended_life_span1.10688002
92MP0000428_abnormal_craniofacial_morphol1.09084276
93MP0000343_altered_response_to1.08733737
94MP0003279_aneurysm1.08121422
95MP0000249_abnormal_blood_vessel1.07870831
96MP0000432_abnormal_head_morphology1.07191776
97MP0003950_abnormal_plasma_membrane1.06985745
98MP0005395_other_phenotype1.04359737
99MP0000767_abnormal_smooth_muscle1.03869981
100MP0001765_abnormal_ion_homeostasis1.03741222
101MP0003861_abnormal_nervous_system1.02704462
102MP0000579_abnormal_nail_morphology1.00425311
103MP0006138_congestive_heart_failure0.99509501
104MP0000383_abnormal_hair_follicle0.98276526
105MP0001299_abnormal_eye_distance/0.96397069
106MP0005647_abnormal_sex_gland0.91877550
107MP0009643_abnormal_urine_homeostasis0.91393327
108MP0002136_abnormal_kidney_physiology0.89481901
109MP0009384_cardiac_valve_regurgitation0.87714536
110MP0001188_hyperpigmentation0.87679932
111MP0010678_abnormal_skin_adnexa0.87126601
112MP0002332_abnormal_exercise_endurance0.86470214
113MP0005365_abnormal_bile_salt0.86423605
114MP0005187_abnormal_penis_morphology0.85081116
115MP0001666_abnormal_nutrient_absorption0.83789774
116MP0005275_abnormal_skin_tensile0.83435710
117MP0001175_abnormal_lung_morphology0.82656233
118MP0005360_urolithiasis0.82647938
119MP0003935_abnormal_craniofacial_develop0.81866808
120MP0002128_abnormal_blood_circulation0.80954250
121MP0002090_abnormal_vision0.80905103
122MP0000049_abnormal_middle_ear0.80818212
123MP0004085_abnormal_heartbeat0.79995165
124MP0010307_abnormal_tumor_latency0.79435755
125MP0005397_hematopoietic_system_phenotyp0.79412252
126MP0001545_abnormal_hematopoietic_system0.79412252
127MP0001485_abnormal_pinna_reflex0.79039854
128MP0002098_abnormal_vibrissa_morphology0.78561665
129MP0002163_abnormal_gland_morphology0.77754987
130MP0003690_abnormal_glial_cell0.76848626
131MP0002118_abnormal_lipid_homeostasis0.73780630
132MP0003119_abnormal_digestive_system0.73488282
133MP0001944_abnormal_pancreas_morphology0.73121771
134MP0002233_abnormal_nose_morphology0.73061067
135MP0000604_amyloidosis0.72929508
136MP0000613_abnormal_salivary_gland0.71863048
137MP0003942_abnormal_urinary_system0.70967794
138MP0009697_abnormal_copulation0.70048070
139MP0000470_abnormal_stomach_morphology0.69194170
140MP0001915_intracranial_hemorrhage0.68744092
141MP0004233_abnormal_muscle_weight0.68346530
142MP0003115_abnormal_respiratory_system0.68203531
143MP0005636_abnormal_mineral_homeostasis0.68008194
144MP0004264_abnormal_extraembryonic_tissu0.67603198
145MP0002925_abnormal_cardiovascular_devel0.66254957
146MP0000534_abnormal_ureter_morphology0.65772007
147MP0003303_peritoneal_inflammation0.64980729
148MP0004185_abnormal_adipocyte_glucose0.63622531
149MP0000230_abnormal_systemic_arterial0.62961476
150MP0005501_abnormal_skin_physiology0.62607401
151MP0001544_abnormal_cardiovascular_syste0.62278452
152MP0005385_cardiovascular_system_phenoty0.62278452
153MP0005076_abnormal_cell_differentiation0.62004205
154MP0008770_decreased_survivor_rate0.61815112
155MP0002972_abnormal_cardiac_muscle0.60692396
156MP0000266_abnormal_heart_morphology0.60227142
157MP0010630_abnormal_cardiac_muscle0.58972901
158MP0002089_abnormal_postnatal_growth/wei0.58909726
159MP0001756_abnormal_urination0.58401393
160MP0003943_abnormal_hepatobiliary_system0.58133692
161MP0002282_abnormal_trachea_morphology0.57819834
162MP0009053_abnormal_anal_canal0.57543516
163MP0000313_abnormal_cell_death0.57419594
164MP0000762_abnormal_tongue_morphology0.57366137
165MP0002653_abnormal_ependyma_morphology0.55929292
166MP0002249_abnormal_larynx_morphology0.55887652
167MP0005623_abnormal_meninges_morphology0.55458492
168MP0008438_abnormal_cutaneous_collagen0.55370014
169MP0005394_taste/olfaction_phenotype0.54654644
170MP0005499_abnormal_olfactory_system0.54654644
171MP0003938_abnormal_ear_development0.54653459
172MP0000631_abnormal_neuroendocrine_gland0.54085737
173MP0004510_myositis0.53893682
174MP0001851_eye_inflammation0.53025529
175MP0003186_abnormal_redox_activity0.52462561
176MP0002081_perinatal_lethality0.52378336
177MP0003638_abnormal_response/metabolism_0.52293552
178MP0001614_abnormal_blood_vessel0.52149974

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.26493844
2Interstitial pulmonary disease (HP:0006530)6.85759875
3Hyperactive renin-angiotensin system (HP:0000841)6.63193901
4Renal salt wasting (HP:0000127)5.30966983
5Hyperkalemia (HP:0002153)5.27113523
6Abnormality of the nasal mucosa (HP:0000433)5.10583084
7Polycythemia (HP:0001901)4.70002564
8Tubulointerstitial fibrosis (HP:0005576)4.59808169
9Hepatoblastoma (HP:0002884)4.52229812
10Esophageal varix (HP:0002040)4.36047143
11Gout (HP:0001997)4.23734536
12Abnormality of the labia minora (HP:0012880)3.96508893
13Hematochezia (HP:0002573)3.79876689
14Bronchitis (HP:0012387)3.75599466
15Delayed CNS myelination (HP:0002188)3.74243635
16Bronchiectasis (HP:0002110)3.66745089
17Abnormality of chloride homeostasis (HP:0011422)3.64203698
18Choanal stenosis (HP:0000452)3.49673199
19Dysmetric saccades (HP:0000641)3.34762031
20Genetic anticipation (HP:0003743)3.32868477
21Spastic diplegia (HP:0001264)3.31447588
22Septo-optic dysplasia (HP:0100842)3.28667406
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22931423
24Hypotension (HP:0002615)3.22553987
25Abnormal respiratory motile cilium physiology (HP:0012261)3.21342786
26Tubulointerstitial nephritis (HP:0001970)3.19458170
27Abnormal ciliary motility (HP:0012262)3.18558610
28Selective tooth agenesis (HP:0001592)3.16550813
29Spontaneous hematomas (HP:0007420)3.16256404
30Colon cancer (HP:0003003)3.15229338
31Stridor (HP:0010307)3.14747811
32Nephroblastoma (Wilms tumor) (HP:0002667)3.12596974
33Nasal polyposis (HP:0100582)3.12284271
34Abnormality of the fetal cardiovascular system (HP:0010948)3.06973301
35Abnormal umbilical cord blood vessels (HP:0011403)3.06973301
36Single umbilical artery (HP:0001195)3.06973301
37Hyperaldosteronism (HP:0000859)3.04969704
38Dynein arm defect of respiratory motile cilia (HP:0012255)3.01075954
39Absent/shortened dynein arms (HP:0200106)3.01075954
40Embryonal renal neoplasm (HP:0011794)3.00109626
41Bilateral microphthalmos (HP:0007633)2.98898414
42Deep venous thrombosis (HP:0002625)2.95440313
43Abnormality of the fingertips (HP:0001211)2.94650280
44Rhinitis (HP:0012384)2.93364199
45Pulmonary artery stenosis (HP:0004415)2.88510299
46Chronic sinusitis (HP:0011109)2.86364945
47Tachypnea (HP:0002789)2.80111507
48Respiratory distress (HP:0002098)2.76805636
49Tubulointerstitial abnormality (HP:0001969)2.67386718
50Visceral angiomatosis (HP:0100761)2.65500386
51Onycholysis (HP:0001806)2.64963893
52Cerebral hemorrhage (HP:0001342)2.64858646
53Abnormality of renin-angiotensin system (HP:0000847)2.64805371
54Birth length less than 3rd percentile (HP:0003561)2.61840384
55Ulnar bowing (HP:0003031)2.61472290
56Abnormal respiratory epithelium morphology (HP:0012253)2.59129242
57Abnormal respiratory motile cilium morphology (HP:0005938)2.59129242
58Absent radius (HP:0003974)2.58668940
59Neurofibrillary tangles (HP:0002185)2.53818761
60Abdominal situs inversus (HP:0003363)2.53400374
61Abnormality of abdominal situs (HP:0011620)2.53400374
62Decreased circulating renin level (HP:0003351)2.43940269
63Absent forearm bone (HP:0003953)2.41609070
64Aplasia involving forearm bones (HP:0009822)2.41609070
65Midline defect of the nose (HP:0004122)2.40865644
66Malignant gastrointestinal tract tumors (HP:0006749)2.39067515
67Gastrointestinal carcinoma (HP:0002672)2.39067515
68Chronic otitis media (HP:0000389)2.37400442
69Hemangiomatosis (HP:0007461)2.31838852
70Multiple enchondromatosis (HP:0005701)2.30554409
71Hyponatremia (HP:0002902)2.29984379
72Facial cleft (HP:0002006)2.28534538
73Abnormality of the lacrimal duct (HP:0011481)2.27995905
74Cortical dysplasia (HP:0002539)2.27840462
75Skull defect (HP:0001362)2.26619165
76Maternal diabetes (HP:0009800)2.25917416
77Cerebral aneurysm (HP:0004944)2.25323043
78Preaxial foot polydactyly (HP:0001841)2.25292363
79Tubular atrophy (HP:0000092)2.24025273
80Aqueductal stenosis (HP:0002410)2.23745168
81Vascular calcification (HP:0004934)2.23603521
82Absent eyebrow (HP:0002223)2.23129317
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.21370201
84Conjunctival telangiectasia (HP:0000524)2.21230457
85Cutaneous syndactyly (HP:0012725)2.20118643
86Abnormality of the septum pellucidum (HP:0007375)2.20036243
87Right ventricular cardiomyopathy (HP:0011663)2.19648817
88Short hallux (HP:0010109)2.18885542
89Abnormal hair whorl (HP:0010721)2.18879468
90Ependymoma (HP:0002888)2.17888543
91Nephritis (HP:0000123)2.16699042
92Annular pancreas (HP:0001734)2.16232189
93Growth hormone excess (HP:0000845)2.15744121
94Abnormality of homocysteine metabolism (HP:0010919)2.15128107
95Homocystinuria (HP:0002156)2.15128107
96Tarsal synostosis (HP:0008368)2.13841952
97Aplasia/Hypoplasia of the sternum (HP:0006714)2.13142217
98Bronchomalacia (HP:0002780)2.13007700
99Supernumerary spleens (HP:0009799)2.11518247
100Abnormal lung lobation (HP:0002101)2.10568482
101Cardiovascular calcification (HP:0011915)2.09937282
102Partial duplication of thumb phalanx (HP:0009944)2.09602556
103Anal stenosis (HP:0002025)2.08920632
104Absent septum pellucidum (HP:0001331)2.08386942
105Biliary tract neoplasm (HP:0100574)2.07434065
106Urethral obstruction (HP:0000796)2.07107534
107Cutaneous finger syndactyly (HP:0010554)2.07042066
108Clumsiness (HP:0002312)2.05419434
109Congenital malformation of the right heart (HP:0011723)2.04643010
110Double outlet right ventricle (HP:0001719)2.04643010
111Hyperglycinuria (HP:0003108)2.03002602
112Abnormality of the salivary glands (HP:0010286)2.01672849
113Recurrent gram-negative bacterial infections (HP:0005420)2.00121308
114Complement deficiency (HP:0004431)1.99516239
115Cerebral inclusion bodies (HP:0100314)1.98079874
116Broad metatarsal (HP:0001783)1.97511455
117Stenosis of the external auditory canal (HP:0000402)1.96567396
118Carpal bone hypoplasia (HP:0001498)1.96511373
119Camptodactyly of toe (HP:0001836)1.96207540
120Cavernous hemangioma (HP:0001048)1.96016032
121Absent eyelashes (HP:0000561)1.94607943
122Late onset (HP:0003584)1.93016759
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92321555
124Milia (HP:0001056)1.92306853
125Mitral stenosis (HP:0001718)1.91470683
126Myelomeningocele (HP:0002475)1.91455691
127Aplasia/Hypoplasia of the hallux (HP:0008362)1.91336355
128Stage 5 chronic kidney disease (HP:0003774)1.90596304
129Hyperuricemia (HP:0002149)1.90352490
130Increased purine levels (HP:0004368)1.90352490
131Mucosal telangiectasiae (HP:0100579)1.90090302
132Breast aplasia (HP:0100783)1.89482817
133Intestinal atresia (HP:0011100)1.88691474
134Uterine neoplasm (HP:0010784)1.88387869
135Synostosis involving bones of the lower limbs (HP:0009138)1.87764466
136Synostosis involving bones of the feet (HP:0009140)1.87764466
137Broad thumb (HP:0011304)1.87399687
138Abnormality of the nasolacrimal system (HP:0000614)1.87108464
139Abnormality of sodium homeostasis (HP:0010931)1.87105877
140Hypoplasia of the pons (HP:0012110)1.86690369
141Shallow orbits (HP:0000586)1.86529226
142Hypokalemic alkalosis (HP:0001949)1.85906979
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85701977
144Aplasia involving bones of the upper limbs (HP:0009823)1.85227253
145Aplasia of the phalanges of the hand (HP:0009802)1.85227253
146Aplasia involving bones of the extremities (HP:0009825)1.85227253
147Esophageal atresia (HP:0002032)1.85063028
148Neoplasm of the adrenal cortex (HP:0100641)1.84967119
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.84451078
150Osteolytic defects of the hand bones (HP:0009699)1.84451078
151Eczematoid dermatitis (HP:0000976)1.83674965
152Clitoromegaly (HP:0000057)1.81568574
153Micronodular cirrhosis (HP:0001413)1.80062272
154Cupped ear (HP:0000378)1.78904434
155Fused cervical vertebrae (HP:0002949)1.78829053
156Intestinal fistula (HP:0100819)1.78543181
157Turricephaly (HP:0000262)1.78541737
158Impulsivity (HP:0100710)1.78414417
159Facial shape deformation (HP:0011334)1.77689650
160Potter facies (HP:0002009)1.77689650
161Omphalocele (HP:0001539)1.77562163
162Abnormality of the pons (HP:0007361)1.76310589
163Hypoplastic female external genitalia (HP:0012815)1.75140257
164Labial hypoplasia (HP:0000066)1.74510500
165Bicornuate uterus (HP:0000813)1.74470740
166Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74314522
167Glomerulosclerosis (HP:0000096)1.73314632
168Aplasia/Hypoplasia of the breasts (HP:0010311)1.73149241
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.73056709
170Coronal craniosynostosis (HP:0004440)1.72786026
171Duplication of thumb phalanx (HP:0009942)1.72610994
172Subacute progressive viral hepatitis (HP:0006572)1.72081669
173Abnormality of the middle phalanges of the toes (HP:0010183)1.71796220
174Vascular tortuosity (HP:0004948)1.67723299
175Adrenal overactivity (HP:0002717)1.67559790
176Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67550961
177Shawl scrotum (HP:0000049)1.63783735
178Neonatal death (HP:0003811)1.63762738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DAPK27.79341894
2TGFBR25.28661796
3TEC3.74770766
4GRK73.48841474
5LATS13.30276811
6CDK123.12818121
7TTK3.06660814
8TIE13.03978922
9CDC73.01488924
10ITK2.94848033
11STK102.88586918
12WNK42.66987360
13MKNK12.61944033
14CDK192.51752741
15MOS2.47800564
16GRK52.38029431
17ERBB42.35330563
18STK38L2.32565827
19MKNK22.22669071
20PTK22.20615787
21EPHB22.09041662
22TAF12.08076484
23MAP3K32.07355999
24TESK12.04460436
25EPHB11.95299763
26CAMK1D1.94552766
27MAP3K91.91738621
28MAP3K101.89910804
29MAP3K111.83427310
30MAP3K121.82068467
31TSSK61.81185407
32TNIK1.81113075
33STK31.79228033
34TAOK11.78836428
35BRD41.74560321
36LATS21.74075376
37PBK1.72703180
38VRK21.72385286
39SRPK11.71743308
40PASK1.70372551
41BTK1.69910258
42CAMK1G1.68965680
43LIMK11.67914162
44SMG11.66012780
45MAP2K31.65747960
46BUB11.60489264
47PLK31.58352824
48NME11.52024266
49BMX1.43547483
50ERBB31.42155588
51EEF2K1.41087831
52FGFR11.37611453
53NLK1.35431910
54PLK41.35113481
55NEK21.32232828
56TAOK31.32010279
57LRRK21.31243972
58BRSK21.29473719
59FGFR21.27544660
60WNK11.27360733
61MST41.23359318
62DYRK31.21697092
63ACVR1B1.19070052
64RPS6KB21.17094611
65EIF2AK21.16765080
66ZAK1.15396892
67DYRK21.09171297
68GRK11.08870918
69PLK11.08367708
70NUAK11.08147833
71PAK41.08068483
72STK241.06937107
73SGK21.01673664
74CHEK21.00179511
75ALK0.99793936
76MAPK150.97884576
77OXSR10.97418406
78AKT30.96079814
79IKBKE0.93381300
80DMPK0.90910973
81PTK60.90030083
82ZAP700.88680278
83FER0.85976621
84SGK2230.83334886
85SGK4940.83334886
86INSRR0.83184377
87MYLK0.79718882
88DAPK10.79665784
89STK390.79050416
90TAOK20.78495269
91ATM0.77647865
92PRKCE0.77248291
93SGK30.75364698
94MAP3K20.74790457
95EPHA20.74496611
96CHEK10.73800686
97DAPK30.72531241
98FGFR40.71727591
99STK160.70452559
100KDR0.69594754
101CDK70.62668824
102ATR0.60060985
103PDGFRB0.59842073
104IGF1R0.59641966
105MAP3K10.57438108
106YES10.56669173
107CSNK1G10.56440830
108PRKCH0.56429024
109EPHA30.55452791
110MTOR0.55093754
111CDK10.54567889
112BMPR1B0.54007392
113CDK20.52780969
114GSK3A0.51967523
115TBK10.51211096
116WNK30.50353221
117TRPM70.49460661
118RIPK10.49373434
119ERBB20.49146989
120CDK40.45920306
121PDK30.45510031
122PDK40.45510031
123PRKDC0.44467452
124PIM10.44409406
125MAPKAPK20.43738109
126AURKB0.43272817
127MAP3K80.42582267
128WEE10.42229803
129DYRK1A0.42219383
130MELK0.41739947
131GSK3B0.41406319
132ILK0.41351578
133TYRO30.41129310
134INSR0.40762451
135CSNK1E0.40707768
136ADRBK10.40477219
137STK40.40403569
138CDK30.39985075
139LMTK20.38979854
140EGFR0.38172792
141PTK2B0.37256676
142CSK0.36397207
143CDK90.36379533
144CDK60.35315658
145CDC42BPA0.32493322
146PDK20.32489565
147MAP3K140.32003918
148TRIB30.31038596
149BCR0.30504085
150CHUK0.29962616
151MET0.29864167
152JAK20.29292507
153SRC0.26264418
154KSR20.25926560
155MAP2K40.25280914
156PRKCD0.24828952
157PDGFRA0.23371356
158FGFR30.22513373
159TTN0.21831157
160ERN10.20997151
161EPHA40.19684019
162MST1R0.18802076
163FRK0.18147984
164TGFBR10.17036064
165NTRK30.16932985
166PAK30.16677310
167PRKG20.13736892
168HIPK20.13609443
169PRKACB0.13193518
170NTRK10.12740204
171ABL10.11820048
172IRAK40.11017196
173PRKD10.11016159
174CAMK2B0.10935269
175DDR20.10234970

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.75254139
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.29808102
3Bladder cancer_Homo sapiens_hsa052193.14610258
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.94227643
5Cysteine and methionine metabolism_Homo sapiens_hsa002702.78944496
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65458809
7Chemical carcinogenesis_Homo sapiens_hsa052042.60408626
8Mismatch repair_Homo sapiens_hsa034302.59399998
9DNA replication_Homo sapiens_hsa030302.54976955
10mRNA surveillance pathway_Homo sapiens_hsa030152.47609213
11Cell cycle_Homo sapiens_hsa041102.39330443
12RNA transport_Homo sapiens_hsa030132.35413264
13Non-homologous end-joining_Homo sapiens_hsa034502.26909854
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16824471
15ECM-receptor interaction_Homo sapiens_hsa045122.02814703
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02104211
17Leukocyte transendothelial migration_Homo sapiens_hsa046702.01630466
18Spliceosome_Homo sapiens_hsa030401.97072235
19Lysine degradation_Homo sapiens_hsa003101.96389416
20Histidine metabolism_Homo sapiens_hsa003401.92552161
21Tight junction_Homo sapiens_hsa045301.86066640
22Basal transcription factors_Homo sapiens_hsa030221.82637807
23Adherens junction_Homo sapiens_hsa045201.80355016
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71800402
25Glutathione metabolism_Homo sapiens_hsa004801.71654314
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70277870
27Base excision repair_Homo sapiens_hsa034101.69604066
28Basal cell carcinoma_Homo sapiens_hsa052171.68500277
29Complement and coagulation cascades_Homo sapiens_hsa046101.67106191
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64059308
31One carbon pool by folate_Homo sapiens_hsa006701.60957150
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58377061
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51357454
34Tryptophan metabolism_Homo sapiens_hsa003801.51130681
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46219551
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45662698
37Phagosome_Homo sapiens_hsa041451.44310115
38Amoebiasis_Homo sapiens_hsa051461.43433448
39Circadian rhythm_Homo sapiens_hsa047101.40938162
40Wnt signaling pathway_Homo sapiens_hsa043101.40848960
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37603431
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36269562
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34057585
44Renin secretion_Homo sapiens_hsa049241.33626123
45Focal adhesion_Homo sapiens_hsa045101.30131170
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29661040
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28823881
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28442530
49RNA degradation_Homo sapiens_hsa030181.28387365
50MicroRNAs in cancer_Homo sapiens_hsa052061.26189637
51Arginine and proline metabolism_Homo sapiens_hsa003301.24767788
52RNA polymerase_Homo sapiens_hsa030201.20349944
53Homologous recombination_Homo sapiens_hsa034401.12008645
54Biosynthesis of amino acids_Homo sapiens_hsa012301.10469139
55Phenylalanine metabolism_Homo sapiens_hsa003601.07707853
56Selenocompound metabolism_Homo sapiens_hsa004501.06613766
57Salivary secretion_Homo sapiens_hsa049701.05318600
58Renin-angiotensin system_Homo sapiens_hsa046141.04751228
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04526940
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02983149
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01091666
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.99065727
63Oocyte meiosis_Homo sapiens_hsa041140.94000221
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92650847
65Caffeine metabolism_Homo sapiens_hsa002320.92607041
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92543667
67Pyruvate metabolism_Homo sapiens_hsa006200.90625812
68p53 signaling pathway_Homo sapiens_hsa041150.89629339
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87263177
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86687216
71Hippo signaling pathway_Homo sapiens_hsa043900.85943199
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85872694
73Retinol metabolism_Homo sapiens_hsa008300.85766858
74Vibrio cholerae infection_Homo sapiens_hsa051100.84954351
75Sulfur metabolism_Homo sapiens_hsa009200.84301794
76Small cell lung cancer_Homo sapiens_hsa052220.84016798
77Nitrogen metabolism_Homo sapiens_hsa009100.83813601
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83508367
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.82979001
80Rap1 signaling pathway_Homo sapiens_hsa040150.82325169
81Proteoglycans in cancer_Homo sapiens_hsa052050.79450584
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78071666
83Fatty acid elongation_Homo sapiens_hsa000620.76150146
84Fatty acid degradation_Homo sapiens_hsa000710.76133614
85Notch signaling pathway_Homo sapiens_hsa043300.75409405
86Arachidonic acid metabolism_Homo sapiens_hsa005900.75219062
87Vitamin digestion and absorption_Homo sapiens_hsa049770.75091930
88Proteasome_Homo sapiens_hsa030500.74574114
89TGF-beta signaling pathway_Homo sapiens_hsa043500.74518046
90Renal cell carcinoma_Homo sapiens_hsa052110.74337714
91Bile secretion_Homo sapiens_hsa049760.73646653
92Nucleotide excision repair_Homo sapiens_hsa034200.72901378
93Pertussis_Homo sapiens_hsa051330.72768896
94Axon guidance_Homo sapiens_hsa043600.72603221
95Apoptosis_Homo sapiens_hsa042100.70434392
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.69627104
97Platelet activation_Homo sapiens_hsa046110.69539536
98Lysosome_Homo sapiens_hsa041420.67574751
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67104064
100Collecting duct acid secretion_Homo sapiens_hsa049660.65134831
101Staphylococcus aureus infection_Homo sapiens_hsa051500.64042438
102Thyroid cancer_Homo sapiens_hsa052160.63692780
103Colorectal cancer_Homo sapiens_hsa052100.63633370
104Mineral absorption_Homo sapiens_hsa049780.63377169
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.62868301
106Starch and sucrose metabolism_Homo sapiens_hsa005000.62021839
107Pathways in cancer_Homo sapiens_hsa052000.61564211
108Tyrosine metabolism_Homo sapiens_hsa003500.61381369
109Ether lipid metabolism_Homo sapiens_hsa005650.60967495
110Prostate cancer_Homo sapiens_hsa052150.60454945
111Propanoate metabolism_Homo sapiens_hsa006400.60235246
112Synaptic vesicle cycle_Homo sapiens_hsa047210.59150317
113Endocytosis_Homo sapiens_hsa041440.58681953
114Hepatitis C_Homo sapiens_hsa051600.58064372
115Dilated cardiomyopathy_Homo sapiens_hsa054140.57491018
116Viral myocarditis_Homo sapiens_hsa054160.56892371
117Purine metabolism_Homo sapiens_hsa002300.56203392
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55527203
119Hedgehog signaling pathway_Homo sapiens_hsa043400.55039631
120Taste transduction_Homo sapiens_hsa047420.54819427
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54806563
122VEGF signaling pathway_Homo sapiens_hsa043700.54681413
123beta-Alanine metabolism_Homo sapiens_hsa004100.54571192
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54388612
125Nicotine addiction_Homo sapiens_hsa050330.54212749
126Rheumatoid arthritis_Homo sapiens_hsa053230.54184040
127Thyroid hormone synthesis_Homo sapiens_hsa049180.53657414
128Toxoplasmosis_Homo sapiens_hsa051450.53308945
129Prion diseases_Homo sapiens_hsa050200.53277076
130Fanconi anemia pathway_Homo sapiens_hsa034600.53064343
131PPAR signaling pathway_Homo sapiens_hsa033200.52558638
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51656599
133Arginine biosynthesis_Homo sapiens_hsa002200.50176723
134Chronic myeloid leukemia_Homo sapiens_hsa052200.49881655
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49249937
136Pancreatic cancer_Homo sapiens_hsa052120.48709271
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48010642
138Estrogen signaling pathway_Homo sapiens_hsa049150.47234216
139Cocaine addiction_Homo sapiens_hsa050300.46801294
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46534360
141Serotonergic synapse_Homo sapiens_hsa047260.46035423
142cAMP signaling pathway_Homo sapiens_hsa040240.45877273
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.45781113
144Sphingolipid metabolism_Homo sapiens_hsa006000.45645278
145Shigellosis_Homo sapiens_hsa051310.45358198
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44652501
147GnRH signaling pathway_Homo sapiens_hsa049120.42722629
148Peroxisome_Homo sapiens_hsa041460.42560125
149Gastric acid secretion_Homo sapiens_hsa049710.42499533
150Malaria_Homo sapiens_hsa051440.40748076
151Circadian entrainment_Homo sapiens_hsa047130.40496908
152Carbon metabolism_Homo sapiens_hsa012000.39524960
153Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39055566
154GABAergic synapse_Homo sapiens_hsa047270.38089222
155Protein digestion and absorption_Homo sapiens_hsa049740.37372321
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37322480
157Fatty acid metabolism_Homo sapiens_hsa012120.36678506
158Acute myeloid leukemia_Homo sapiens_hsa052210.36521353
159Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35049075
160Folate biosynthesis_Homo sapiens_hsa007900.32273773
161Steroid biosynthesis_Homo sapiens_hsa001000.31628043
162Melanogenesis_Homo sapiens_hsa049160.30884905
163Ras signaling pathway_Homo sapiens_hsa040140.29878185
164Pyrimidine metabolism_Homo sapiens_hsa002400.27090591

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