SCGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)7.09749428
2peptide hormone processing (GO:0016486)6.33932932
3retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.23882567
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.14655651
5signal peptide processing (GO:0006465)6.09251464
6response to pheromone (GO:0019236)6.08167638
7cellular ketone body metabolic process (GO:0046950)5.86298472
8COPII vesicle coating (GO:0048208)5.83304224
9regulation of type B pancreatic cell apoptotic process (GO:2000674)5.82505564
10glandular epithelial cell differentiation (GO:0002067)5.56201789
11positive regulation of insulin secretion (GO:0032024)5.54348418
12protein maturation by protein folding (GO:0022417)5.42839894
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.37334970
14protein retention in ER lumen (GO:0006621)5.31345484
15insulin secretion (GO:0030073)5.30892926
16sequestering of metal ion (GO:0051238)5.20781901
17ketone body metabolic process (GO:1902224)5.17919908
18inositol phosphate catabolic process (GO:0071545)4.91977662
19regulation of insulin secretion (GO:0050796)4.71487557
20positive regulation of peptide hormone secretion (GO:0090277)4.49529640
21inositol phosphate dephosphorylation (GO:0046855)4.48565701
22phosphorylated carbohydrate dephosphorylation (GO:0046838)4.48565701
23vesicle coating (GO:0006901)4.42510844
24detection of calcium ion (GO:0005513)4.38656969
25positive regulation of peptide secretion (GO:0002793)4.32537283
26regulation of peptide hormone secretion (GO:0090276)4.30124750
27negative regulation of protein oligomerization (GO:0032460)4.27979890
28regulation of peptide secretion (GO:0002791)4.21452516
29activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.21212064
30regulation of glucocorticoid secretion (GO:2000849)4.17864867
31ER overload response (GO:0006983)4.14151775
32glandular epithelial cell development (GO:0002068)4.11067045
33exocrine pancreas development (GO:0031017)4.08268795
34glycerophospholipid catabolic process (GO:0046475)4.04155848
35nitric oxide mediated signal transduction (GO:0007263)4.03708753
36negative regulation of glycoprotein biosynthetic process (GO:0010561)4.02522471
37positive regulation of nuclease activity (GO:0032075)3.97295297
38epithelial cell fate commitment (GO:0072148)3.96406565
39type B pancreatic cell development (GO:0003323)3.96225265
40water-soluble vitamin biosynthetic process (GO:0042364)3.92863742
41fatty acid homeostasis (GO:0055089)3.92647673
42peptide hormone secretion (GO:0030072)3.89000464
43L-alpha-amino acid transmembrane transport (GO:1902475)3.84124394
44negative regulation of hormone biosynthetic process (GO:0032353)3.83544383
45polyol catabolic process (GO:0046174)3.83133881
46toxin metabolic process (GO:0009404)3.80771079
47intra-Golgi vesicle-mediated transport (GO:0006891)3.80044082
48peptide secretion (GO:0002790)3.79001268
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78593929
50regulation of hormone secretion (GO:0046883)3.78224873
51positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.76396331
52GDP-mannose metabolic process (GO:0019673)3.75584907
53respiratory chain complex IV assembly (GO:0008535)3.72347246
54negative regulation of gluconeogenesis (GO:0045721)3.71692726
55positive regulation of respiratory burst (GO:0060267)3.62958875
56regulation of nuclease activity (GO:0032069)3.62869326
57negative regulation of insulin secretion (GO:0046676)3.60471883
58ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.58657981
59positive regulation of hormone secretion (GO:0046887)3.55534969
60cellular response to unfolded protein (GO:0034620)3.52868637
61cellular response to topologically incorrect protein (GO:0035967)3.52712284
62regulation of corticosteroid hormone secretion (GO:2000846)3.52588732
63negative regulation of acute inflammatory response (GO:0002674)3.52554787
64cellular zinc ion homeostasis (GO:0006882)3.50806126
65endoplasmic reticulum unfolded protein response (GO:0030968)3.50219350
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.48441155
67L-phenylalanine catabolic process (GO:0006559)3.48441155
68regulation of glucokinase activity (GO:0033131)3.45488399
69regulation of hexokinase activity (GO:1903299)3.45488399
70negative regulation of neurological system process (GO:0031645)3.43925012
71regulation of peptide transport (GO:0090087)3.41678404
72zinc ion homeostasis (GO:0055069)3.41393132
73cytochrome complex assembly (GO:0017004)3.39496137
74ER to Golgi vesicle-mediated transport (GO:0006888)3.36044460
75negative regulation of hormone metabolic process (GO:0032351)3.35023411
76astrocyte differentiation (GO:0048708)3.33778909
77columnar/cuboidal epithelial cell development (GO:0002066)3.29803360
78regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.29549896
79cellular response to vitamin D (GO:0071305)3.27433345
80response to dietary excess (GO:0002021)3.27332331
81positive regulation of macroautophagy (GO:0016239)3.26824594
82cellular response to glucagon stimulus (GO:0071377)3.26350885
83positive regulation of protein autophosphorylation (GO:0031954)3.25838889
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.24770362
85L-phenylalanine metabolic process (GO:0006558)3.24770362
86lactate metabolic process (GO:0006089)3.24565232
87negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24217465
88ER-nucleus signaling pathway (GO:0006984)3.22913565
89positive regulation of glycolytic process (GO:0045821)3.22847166
90negative regulation of catecholamine secretion (GO:0033604)3.22275551
91dendritic spine morphogenesis (GO:0060997)3.21955395
92chemosensory behavior (GO:0007635)3.17450931
93hormone secretion (GO:0046879)3.16674979
94pharyngeal system development (GO:0060037)3.14644411
95negative regulation of peptide hormone secretion (GO:0090278)3.14331175
96protein localization to Golgi apparatus (GO:0034067)3.11480406
97regulation of uterine smooth muscle contraction (GO:0070472)3.10937681
98negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.10129260
99protein N-linked glycosylation via asparagine (GO:0018279)3.10049254
100intraciliary transport (GO:0042073)3.09672477
101peptidyl-asparagine modification (GO:0018196)3.08633994
102peptide transport (GO:0015833)3.07842165
103phenylpropanoid metabolic process (GO:0009698)3.07752082
104negative regulation of glycogen metabolic process (GO:0070874)3.05104290
105negative regulation of glycoprotein metabolic process (GO:1903019)3.04386882
106response to hexose (GO:0009746)3.04111731
107neuron fate specification (GO:0048665)3.03746859
108positive regulation of response to extracellular stimulus (GO:0032106)3.03684118
109positive regulation of response to nutrient levels (GO:0032109)3.03684118
110regulation of autophagic vacuole assembly (GO:2000785)3.02067465
111negative regulation of peptide secretion (GO:0002792)3.02001218
112nucleoside diphosphate catabolic process (GO:0009134)3.01482325
113detection of light stimulus involved in visual perception (GO:0050908)2.98337050
114detection of light stimulus involved in sensory perception (GO:0050962)2.98337050
115hormone transport (GO:0009914)2.98272768
116signal transduction involved in regulation of gene expression (GO:0023019)2.97942611
117response to glucose (GO:0009749)2.97645513
118regulation of energy homeostasis (GO:2000505)2.96560422
119regulation of oxidative phosphorylation (GO:0002082)2.96423440
120negative regulation of norepinephrine secretion (GO:0010700)2.95059917
121positive regulation of vesicle fusion (GO:0031340)2.94569030
122regulation of Golgi to plasma membrane protein transport (GO:0042996)2.92357276
1233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.92233765
124purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.92233765
125regulation of calcium ion-dependent exocytosis (GO:0017158)2.92059847
126eating behavior (GO:0042755)2.90683844
127response to endoplasmic reticulum stress (GO:0034976)2.89959004
128negative regulation of execution phase of apoptosis (GO:1900118)2.88489820
129dentate gyrus development (GO:0021542)2.88489006
130response to monosaccharide (GO:0034284)2.88100521
131zinc ion transmembrane transport (GO:0071577)2.88021303
132macroautophagy (GO:0016236)2.86881042
133glucose homeostasis (GO:0042593)2.86777961
134carbohydrate homeostasis (GO:0033500)2.86777961
135auditory receptor cell differentiation (GO:0042491)2.83836103
136positive regulation of gluconeogenesis (GO:0045722)2.83106538
137positive regulation of glycogen biosynthetic process (GO:0045725)2.80356083
138regulation of glycolytic process (GO:0006110)2.77718847
139xenobiotic catabolic process (GO:0042178)2.77579583
140zinc ion transport (GO:0006829)2.76368287
141nitric oxide biosynthetic process (GO:0006809)2.72737993
142regulation of protein glycosylation (GO:0060049)2.72677010
143kidney morphogenesis (GO:0060993)2.72638693
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.66534423
145positive regulation of calcium ion import (GO:0090280)2.65309888
146calcium ion import (GO:0070509)2.63568871
147sphingomyelin metabolic process (GO:0006684)2.58874603
148neuromuscular process controlling posture (GO:0050884)2.57654053
149positive regulation of nitric-oxide synthase activity (GO:0051000)2.56494573
150positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.56251939
151branched-chain amino acid catabolic process (GO:0009083)2.55353913
152toxin transport (GO:1901998)2.55123237
153positive regulation of meiosis (GO:0045836)2.51810739
154pteridine-containing compound biosynthetic process (GO:0042559)2.44867147
155Golgi transport vesicle coating (GO:0048200)10.3746304
156COPI coating of Golgi vesicle (GO:0048205)10.3746304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.29444879
2PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.17276951
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.12597996
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94963688
5GATA1_22025678_ChIP-Seq_K562_Human3.03677249
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.49994579
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26744661
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25602199
9GBX2_23144817_ChIP-Seq_PC3_Human2.07472555
10IGF1R_20145208_ChIP-Seq_DFB_Human2.04366159
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01626500
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01184511
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97975754
14REST_21632747_ChIP-Seq_MESCs_Mouse1.94565290
15VDR_22108803_ChIP-Seq_LS180_Human1.93932369
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88488511
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.86802441
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.80573896
19OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.73917303
20FUS_26573619_Chip-Seq_HEK293_Human1.73534864
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68957238
22HTT_18923047_ChIP-ChIP_STHdh_Human1.68381628
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68381595
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64113309
25SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.63703872
26* P300_19829295_ChIP-Seq_ESCs_Human1.63200381
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.57440995
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56993183
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53753767
30* AR_25329375_ChIP-Seq_VCAP_Human1.53600594
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47588344
32* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.47487706
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45424960
34ER_23166858_ChIP-Seq_MCF-7_Human1.44876355
35TAF15_26573619_Chip-Seq_HEK293_Human1.44246205
36CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.43340958
37* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42893515
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42684779
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42048441
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41518764
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.39858073
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37560327
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36463285
44CBP_20019798_ChIP-Seq_JUKART_Human1.35576376
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35576376
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35244020
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35171571
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34825369
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33711758
50P53_22387025_ChIP-Seq_ESCs_Mouse1.33608021
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.32571157
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31317166
53CDX2_22108803_ChIP-Seq_LS180_Human1.30087433
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.29736440
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.29101810
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29018352
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27940877
58FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27832399
59* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26892678
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.25419259
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23479852
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21794194
63NANOG_19829295_ChIP-Seq_ESCs_Human1.21748379
64SOX2_19829295_ChIP-Seq_ESCs_Human1.21748379
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21562272
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21231520
67EWS_26573619_Chip-Seq_HEK293_Human1.20969208
68TP53_22573176_ChIP-Seq_HFKS_Human1.20945412
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.20554679
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20275437
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.19125744
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18172802
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18133030
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.17482086
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17347410
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17179159
77ZNF274_21170338_ChIP-Seq_K562_Hela1.16993879
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16818785
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.16474342
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.16418934
81STAT3_23295773_ChIP-Seq_U87_Human1.16086855
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14522786
83CTCF_18555785_Chip-Seq_ESCs_Mouse1.13525926
84FOXA1_25552417_ChIP-Seq_VCAP_Human1.12316800
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.12189296
86P300_18555785_Chip-Seq_ESCs_Mouse1.09812381
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09689291
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08184857
89* TCF4_22108803_ChIP-Seq_LS180_Human1.08035054
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.07812643
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.07807430
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07154663
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06259946
94DROSHA_22980978_ChIP-Seq_HELA_Human1.06012002
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04938649
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.04409014
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.04301329
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04177356
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03720045
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02132472
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00715797
102RUNX2_22187159_ChIP-Seq_PCA_Human1.00273196
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99766077
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99000246
105OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98424084
106OCT4_18555785_Chip-Seq_ESCs_Mouse0.98103602
107TFEB_21752829_ChIP-Seq_HELA_Human0.97998126
108TBL1_22424771_ChIP-Seq_293T_Human0.97968536
109EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97647026
110NCOR_22424771_ChIP-Seq_293T_Human0.97600922
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97208756
112RARB_27405468_Chip-Seq_BRAIN_Mouse0.96842050
113ERG_20517297_ChIP-Seq_VCAP_Human0.95138799
114* FLI1_21867929_ChIP-Seq_TH2_Mouse0.94379125
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94216127
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.92001107
117* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91498598
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90796625
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90184678
120BCAT_22108803_ChIP-Seq_LS180_Human0.89648095
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89322626
122JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88216226
123SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88011086
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87771186
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87621883
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86547190
127FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86215818
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85607903
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84340282
130PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84226191
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84221255
132SMAD4_21799915_ChIP-Seq_A2780_Human0.84112936
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83338821
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83180462
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.83101843
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82869186
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82851385
138PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82823469
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82769953
140MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82270245
141AR_20517297_ChIP-Seq_VCAP_Human0.81829229
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80994739
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80745225
144SOX2_21211035_ChIP-Seq_LN229_Gbm0.79718711
145TCF4_23295773_ChIP-Seq_U87_Human0.79577234
146ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78137123
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.76130327
148* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75925320
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.75710487
150FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74592824
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.74514233
152NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.74384703
153EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73380749
154* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72558303
155MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72529743
156SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.72421171
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72353193
158* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72328890
159* FOXA1_25329375_ChIP-Seq_VCAP_Human0.72328890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.04912463
2MP0002877_abnormal_melanocyte_morpholog4.49789549
3MP0010386_abnormal_urinary_bladder4.32051926
4MP0004043_abnormal_pH_regulation4.27835478
5MP0003195_calcinosis3.88346012
6MP0002693_abnormal_pancreas_physiology3.81374637
7MP0003183_abnormal_peptide_metabolism3.79309802
8MP0003283_abnormal_digestive_organ3.75912161
9MP0001944_abnormal_pancreas_morphology3.72190228
10MP0002909_abnormal_adrenal_gland3.65951330
11MP0006072_abnormal_retinal_apoptosis3.43677255
12MP0005379_endocrine/exocrine_gland_phen3.38136007
13MP0010234_abnormal_vibrissa_follicle3.26113455
14MP0009780_abnormal_chondrocyte_physiolo3.16059363
15MP0000678_abnormal_parathyroid_gland3.08805986
16MP0002837_dystrophic_cardiac_calcinosis2.87873355
17MP0005220_abnormal_exocrine_pancreas2.86000661
18MP0000003_abnormal_adipose_tissue2.65642083
19MP0005645_abnormal_hypothalamus_physiol2.51645120
20MP0008877_abnormal_DNA_methylation2.51075993
21MP0002638_abnormal_pupillary_reflex2.42814519
22MP0002078_abnormal_glucose_homeostasis2.24102367
23MP0003123_paternal_imprinting1.88903751
24MP0001986_abnormal_taste_sensitivity1.87173426
25MP0005646_abnormal_pituitary_gland1.84556137
26MP0005253_abnormal_eye_physiology1.81393093
27MP0009046_muscle_twitch1.78009345
28MP0003122_maternal_imprinting1.77046622
29MP0010329_abnormal_lipoprotein_level1.72241917
30MP0001502_abnormal_circadian_rhythm1.69762542
31MP0003172_abnormal_lysosome_physiology1.64428139
32MP0005551_abnormal_eye_electrophysiolog1.61381566
33MP0005332_abnormal_amino_acid1.60197416
34MP0003121_genomic_imprinting1.56749153
35MP0004264_abnormal_extraembryonic_tissu1.55876294
36MP0002928_abnormal_bile_duct1.55733874
37MP0002163_abnormal_gland_morphology1.54124104
38MP0001765_abnormal_ion_homeostasis1.50854186
39MP0003953_abnormal_hormone_level1.41341577
40MP0004270_analgesia1.39365318
41MP0000462_abnormal_digestive_system1.37083644
42MP0005257_abnormal_intraocular_pressure1.34935235
43MP0008961_abnormal_basal_metabolism1.34872760
44MP0002138_abnormal_hepatobiliary_system1.33924264
45MP0006292_abnormal_olfactory_placode1.33366795
46MP0000631_abnormal_neuroendocrine_gland1.33320690
47MP0000516_abnormal_urinary_system1.32580888
48MP0005367_renal/urinary_system_phenotyp1.32580888
49MP0003011_delayed_dark_adaptation1.30082191
50MP0002234_abnormal_pharynx_morphology1.29323777
51MP0002822_catalepsy1.28466950
52MP0004885_abnormal_endolymph1.22664653
53MP0000613_abnormal_salivary_gland1.21678394
54MP0003868_abnormal_feces_composition1.19851465
55MP0001756_abnormal_urination1.19738075
56MP0005365_abnormal_bile_salt1.18460462
57MP0003959_abnormal_lean_body1.18065024
58MP0009745_abnormal_behavioral_response1.13671067
59MP0009643_abnormal_urine_homeostasis1.11371906
60MP0000427_abnormal_hair_cycle1.09430388
61MP0001984_abnormal_olfaction1.09313583
62MP0002896_abnormal_bone_mineralization1.08585142
63MP0002254_reproductive_system_inflammat1.07440593
64MP0005636_abnormal_mineral_homeostasis1.05757358
65MP0005375_adipose_tissue_phenotype1.05325315
66MP0002064_seizures1.03045598
67MP0002090_abnormal_vision1.02645627
68MP0002876_abnormal_thyroid_physiology1.02448047
69MP0006036_abnormal_mitochondrial_physio1.01588586
70MP0001501_abnormal_sleep_pattern1.00262854
71MP0003879_abnormal_hair_cell0.99375075
72MP0005535_abnormal_body_temperature0.98463258
73MP0005174_abnormal_tail_pigmentation0.97728748
74MP0001905_abnormal_dopamine_level0.97418442
75MP0003252_abnormal_bile_duct0.96168992
76MP0005058_abnormal_lysosome_morphology0.94715032
77MP0005386_behavior/neurological_phenoty0.94016504
78MP0004924_abnormal_behavior0.94016504
79MP0005075_abnormal_melanosome_morpholog0.93635419
80MP0002102_abnormal_ear_morphology0.93054903
81MP0010352_gastrointestinal_tract_polyps0.91669537
82MP0005310_abnormal_salivary_gland0.89433591
83MP0001270_distended_abdomen0.88929704
84MP0002277_abnormal_respiratory_mucosa0.88876943
85MP0001661_extended_life_span0.88086761
86MP0003890_abnormal_embryonic-extraembry0.87788858
87MP0002751_abnormal_autonomic_nervous0.85804868
88MP0010678_abnormal_skin_adnexa0.85681722
89MP0005670_abnormal_white_adipose0.85356941
90MP0000639_abnormal_adrenal_gland0.83502457
91MP0005448_abnormal_energy_balance0.83207480
92MP0005085_abnormal_gallbladder_physiolo0.82621622
93MP0000230_abnormal_systemic_arterial0.82090502
94MP0004145_abnormal_muscle_electrophysio0.81207630
95MP0002938_white_spotting0.79878026
96MP0000569_abnormal_digit_pigmentation0.79642371
97MP0002734_abnormal_mechanical_nocicepti0.78797162
98MP0003300_gastrointestinal_ulcer0.76873177
99MP0004215_abnormal_myocardial_fiber0.75545610
100MP0000538_abnormal_urinary_bladder0.75321711
101MP0003787_abnormal_imprinting0.74813548
102MP0002572_abnormal_emotion/affect_behav0.74219432
103MP0008872_abnormal_physiological_respon0.73940927
104MP0001764_abnormal_homeostasis0.73596175
105MP0002733_abnormal_thermal_nociception0.73437750
106MP0005084_abnormal_gallbladder_morpholo0.73003916
107MP0004142_abnormal_muscle_tone0.72004960
108MP0004134_abnormal_chest_morphology0.70691442
109MP0003119_abnormal_digestive_system0.69566804
110MP0003045_fibrosis0.69437232
111MP0002229_neurodegeneration0.65384136
112MP0004085_abnormal_heartbeat0.65043650
113MP0005389_reproductive_system_phenotype0.65017238
114MP0002160_abnormal_reproductive_system0.64826593
115MP0009672_abnormal_birth_weight0.64810156
116MP0002295_abnormal_pulmonary_circulatio0.62658295
117MP0002139_abnormal_hepatobiliary_system0.62307215
118MP0002069_abnormal_eating/drinking_beha0.61887151
119MP0002272_abnormal_nervous_system0.61649302
120MP0001299_abnormal_eye_distance/0.60792400
121MP0005391_vision/eye_phenotype0.60345414
122MP0006054_spinal_hemorrhage0.58201688
123MP0005452_abnormal_adipose_tissue0.57925017
124MP0004782_abnormal_surfactant_physiolog0.57064596
125MP0001970_abnormal_pain_threshold0.56219464
126MP0004233_abnormal_muscle_weight0.56052019
127MP0005334_abnormal_fat_pad0.56006915
128MP0000955_abnormal_spinal_cord0.55974048
129MP0001666_abnormal_nutrient_absorption0.55786699
130MP0001324_abnormal_eye_pigmentation0.54950291
131MP0002557_abnormal_social/conspecific_i0.54540947
132MP0002118_abnormal_lipid_homeostasis0.52507418
133MP0001186_pigmentation_phenotype0.52256670
134MP0002184_abnormal_innervation0.50916043
135MP0000681_abnormal_thyroid_gland0.48555008
136MP0003633_abnormal_nervous_system0.48271149
137MP0009642_abnormal_blood_homeostasis0.47722303
138MP0001664_abnormal_digestion0.47278769
139MP0005408_hypopigmentation0.46678138
140MP0004019_abnormal_vitamin_homeostasis0.46078266

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.69329994
2Hypoglycemic seizures (HP:0002173)7.33469598
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.18501758
4Symptomatic seizures (HP:0011145)6.97275089
5Hypoglycemic coma (HP:0001325)6.19185958
6Abnormality of calcium-phosphate metabolism (HP:0100530)4.94104623
7Hyperglycemia (HP:0003074)4.80754740
8Ketoacidosis (HP:0001993)4.54945163
9Abnormality of endocrine pancreas physiology (HP:0012093)4.49915485
10Abnormality of the pancreatic islet cells (HP:0006476)4.49915485
11Insulin-resistant diabetes mellitus (HP:0000831)4.49111861
12Late onset (HP:0003584)4.17886346
13Pancreatic islet-cell hyperplasia (HP:0004510)4.14694040
14Decreased circulating renin level (HP:0003351)4.11410321
15Large for gestational age (HP:0001520)3.95081428
16Hypomagnesemia (HP:0002917)3.68315312
17Generalized aminoaciduria (HP:0002909)3.65436857
18Enlarged penis (HP:0000040)3.32208370
19Abnormal pancreas size (HP:0012094)3.28610485
20Osteomalacia (HP:0002749)3.16567879
21Hypokalemia (HP:0002900)3.15774978
22Agitation (HP:0000713)3.14854408
23Urinary glycosaminoglycan excretion (HP:0003541)3.14423671
24Mucopolysacchariduria (HP:0008155)3.14423671
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08822546
26Dysostosis multiplex (HP:0000943)2.99723727
27Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95291729
28Abnormality of polysaccharide metabolism (HP:0011012)2.95291729
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95291729
30Aplasia/Hypoplasia of the fovea (HP:0008060)2.92459017
31Hypoplasia of the fovea (HP:0007750)2.92459017
32Abnormality of magnesium homeostasis (HP:0004921)2.82407939
33Neoplasm of the adrenal cortex (HP:0100641)2.81947060
34Dysautonomia (HP:0002459)2.81021008
35Hyperparathyroidism (HP:0000843)2.78291083
36Insulin resistance (HP:0000855)2.78007883
37Abnormality of vitamin B metabolism (HP:0004340)2.75702101
38Methylmalonic acidemia (HP:0002912)2.75534787
39Abnormality of the fovea (HP:0000493)2.74751635
40Hyperkalemia (HP:0002153)2.74710296
41Retinal atrophy (HP:0001105)2.68782227
42Menstrual irregularities (HP:0000858)2.65312776
43Abnormality of potassium homeostasis (HP:0011042)2.65167931
44Abnormality of renin-angiotensin system (HP:0000847)2.64089329
45Ketosis (HP:0001946)2.61743352
46Congenital malformation of the right heart (HP:0011723)2.61512304
47Double outlet right ventricle (HP:0001719)2.61512304
48EEG with generalized epileptiform discharges (HP:0011198)2.60686405
49Abnormal rod and cone electroretinograms (HP:0008323)2.60611520
50Conjunctival hamartoma (HP:0100780)2.58582786
51Hemiparesis (HP:0001269)2.55613069
52Prominent metopic ridge (HP:0005487)2.55088293
53Limb hypertonia (HP:0002509)2.54332380
54Pheochromocytoma (HP:0002666)2.52870186
55Progressive macrocephaly (HP:0004481)2.51147578
56Hepatic necrosis (HP:0002605)2.48783676
57Epileptiform EEG discharges (HP:0011182)2.48178575
58Intestinal atresia (HP:0011100)2.47657416
59Hyperthyroidism (HP:0000836)2.47052744
60Tongue fasciculations (HP:0001308)2.41494988
61Muscular hypotonia of the trunk (HP:0008936)2.41394343
62Hyperactive renin-angiotensin system (HP:0000841)2.39798022
63Conjugated hyperbilirubinemia (HP:0002908)2.37877747
64Abnormality of the intrinsic pathway (HP:0010989)2.36924884
65Hypsarrhythmia (HP:0002521)2.36787776
66Hypokinesia (HP:0002375)2.35617093
67Testicular neoplasm (HP:0010788)2.35285951
68Abnormal glycosylation (HP:0012345)2.29985321
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29985321
70Abnormal protein N-linked glycosylation (HP:0012347)2.29985321
71Abnormal protein glycosylation (HP:0012346)2.29985321
72Type I diabetes mellitus (HP:0100651)2.29158216
73Congenital sensorineural hearing impairment (HP:0008527)2.26991647
74Hamartoma of the eye (HP:0010568)2.26004616
75Abnormality of vitamin metabolism (HP:0100508)2.24065486
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23460615
77Congenital stationary night blindness (HP:0007642)2.21903915
78Chronic bronchitis (HP:0004469)2.19258460
79Sex reversal (HP:0012245)2.18021037
80Abnormal sex determination (HP:0012244)2.18021037
81Hematochezia (HP:0002573)2.17617804
82Hypothermia (HP:0002045)2.17556856
83Hyperphosphatemia (HP:0002905)2.15318460
84Neuroendocrine neoplasm (HP:0100634)2.14522212
85Cortical visual impairment (HP:0100704)2.12951926
86Central scotoma (HP:0000603)2.12882802
87Methylmalonic aciduria (HP:0012120)2.12811957
88Abnormality of the metopic suture (HP:0005556)2.12441540
89Abnormality of chloride homeostasis (HP:0011422)2.11515032
90Gout (HP:0001997)2.10818023
91Neoplasm of the adrenal gland (HP:0100631)2.10283943
92Progressive neurologic deterioration (HP:0002344)2.10235347
93Type I transferrin isoform profile (HP:0003642)2.10009727
94Bony spicule pigmentary retinopathy (HP:0007737)2.08817153
95Glycosuria (HP:0003076)2.08741647
96Abnormality of urine glucose concentration (HP:0011016)2.08741647
97Increased CSF protein (HP:0002922)2.08644727
98Abdominal distention (HP:0003270)2.08502543
99Neoplasm of the heart (HP:0100544)2.05075407
100Type II diabetes mellitus (HP:0005978)2.04237808
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03686050
102Bifid tongue (HP:0010297)2.03014858
103Hypophosphatemia (HP:0002148)2.01240231
104Muscle fibrillation (HP:0010546)2.00155102
105Growth hormone excess (HP:0000845)1.98472094
106Abnormal drinking behavior (HP:0030082)1.97593415
107Polydipsia (HP:0001959)1.97593415
108Abnormality of the renal cortex (HP:0011035)1.95743675
109Hypercortisolism (HP:0001578)1.95487169
110Downturned corners of mouth (HP:0002714)1.95061324
111Restlessness (HP:0000711)1.92862456
112Hypotension (HP:0002615)1.92428344
113Macroorchidism (HP:0000053)1.90748488
114Acute necrotizing encephalopathy (HP:0006965)1.90561813
115Medial flaring of the eyebrow (HP:0010747)1.90237954
116Visual hallucinations (HP:0002367)1.89318272
117Dicarboxylic aciduria (HP:0003215)1.89073908
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89073908
119Anteriorly placed anus (HP:0001545)1.88754060
120Exocrine pancreatic insufficiency (HP:0001738)1.87784209
121Abnormality of macular pigmentation (HP:0008002)1.86743545
122Proximal tubulopathy (HP:0000114)1.86471216
123Thoracolumbar scoliosis (HP:0002944)1.86261105
124Abnormal albumin level (HP:0012116)1.85894752
125Hypoalbuminemia (HP:0003073)1.85894752
126Renal cortical cysts (HP:0000803)1.85373199
127Anxiety (HP:0000739)1.83502592
128Aqueductal stenosis (HP:0002410)1.82660908
129Mitochondrial inheritance (HP:0001427)1.82042568
130Postural tremor (HP:0002174)1.80930371
131Furrowed tongue (HP:0000221)1.79851506
132Aplasia/Hypoplasia of the macula (HP:0008059)1.79020643
133Diminished movement (HP:0002374)1.78500837
134Orthostatic hypotension (HP:0001278)1.77086559
135Enlarged kidneys (HP:0000105)1.76924361
136Tetany (HP:0001281)1.76120031
137Absent eyebrow (HP:0002223)1.75886293
138Adrenal overactivity (HP:0002717)1.75093412
139Thyroiditis (HP:0100646)1.74817662
140Poor suck (HP:0002033)1.73987753
141Vascular calcification (HP:0004934)1.73652362
142Hyperphosphaturia (HP:0003109)1.73478566
143Unilateral renal agenesis (HP:0000122)1.73463171
144Increased circulating renin level (HP:0000848)1.73302284
145Hypobetalipoproteinemia (HP:0003563)1.72786079
146Vacuolated lymphocytes (HP:0001922)1.70290455
147Irregular vertebral endplates (HP:0003301)1.70000770
148Protuberant abdomen (HP:0001538)1.69577311
149Papillary thyroid carcinoma (HP:0002895)1.67982218
150Attenuation of retinal blood vessels (HP:0007843)1.67902933
151Nephronophthisis (HP:0000090)1.65931834
152Hepatoblastoma (HP:0002884)1.65311403
153Increased CSF lactate (HP:0002490)1.65172260
154Pancreatic fibrosis (HP:0100732)1.64620584
155Intention tremor (HP:0002080)1.64118523
156Tachypnea (HP:0002789)1.63090780
157Polyuria (HP:0000103)1.62200720
158Hyperventilation (HP:0002883)1.61403071
159Abnormality of the vitamin B12 metabolism (HP:0004341)1.60949944
160Acute encephalopathy (HP:0006846)1.58645326
161Pancreatic cysts (HP:0001737)1.58595323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.89665473
2MAPK156.72208938
3PASK4.88005079
4FGFR24.27230425
5WNK33.75065511
6EPHA33.11502975
7FRK2.96513028
8PRKD32.75717439
9HIPK22.73707434
10WNK42.59110935
11PIK3CG2.55654906
12PHKG12.41448896
13PHKG22.41448896
14MAP3K22.39600985
15TAOK32.38568693
16FGFR32.29292138
17MST42.25894660
18MAP4K22.11572468
19FLT31.95370476
20GRK11.94607097
21ERN11.89297529
22DAPK21.86617719
23MAP2K61.59452410
24CASK1.55932677
25CAMKK21.53637508
26ACVR1B1.49369022
27IRAK31.48816113
28AKT31.47421499
29MAP3K41.47159489
30UHMK11.41124947
31IRAK11.38358443
32NTRK11.34651911
33TNIK1.32534702
34CDC42BPA1.28555052
35CSNK1G11.27070783
36STK31.23541510
37DYRK1B1.23045915
38PAK31.21897083
39TRPM71.16741310
40BRSK21.15187354
41BRD41.13361762
42BRAF1.13110941
43MAP3K11.09209255
44NTRK31.01231481
45PRKD21.01180571
46PTK20.99107010
47PNCK0.94027157
48PRKAA20.93620212
49EIF2AK30.92619311
50PLK20.91096182
51WNK10.90493337
52CSNK1G20.90005790
53CSNK1G30.88817866
54MAP3K90.86451057
55STK240.85639427
56STK160.84800705
57LIMK10.84667753
58PTK60.83721914
59STK390.80105710
60MAP2K20.79018827
61OXSR10.78117725
62PTK2B0.77803828
63BMPR1B0.77374662
64YES10.77305791
65MAP3K120.77287197
66DYRK1A0.75436090
67STK110.72481818
68STK38L0.70683971
69PDGFRA0.68622657
70SCYL20.68322259
71CAMK1G0.68129164
72IRAK20.67525158
73FER0.65933528
74CAMK2D0.65598336
75PRKCE0.64441446
76PINK10.63578425
77ERBB30.62927435
78BMPR20.62018722
79NUAK10.61362064
80MET0.60762830
81PLK30.59079245
82EIF2AK10.58321599
83PRKCH0.57454038
84NME10.57130563
85PRKAA10.56502086
86MKNK20.49973093
87STK40.49544440
88RIPK10.48597762
89TNK20.48537301
90MAP2K70.48311231
91SGK4940.47581231
92SGK2230.47581231
93BCKDK0.46761896
94SGK30.46360662
95BRSK10.45390831
96ARAF0.45356059
97PRKCZ0.44064409
98EPHA20.43972752
99PRKCI0.43037708
100PRKG10.42903882
101CAMKK10.40986622
102ITK0.40371141
103CSNK1A1L0.40147567
104PAK60.38396034
105ADRBK10.38027395
106DYRK30.37831161
107SIK10.36920716
108TAOK10.35208557
109KSR20.34781406
110NLK0.34629176
111CSK0.34181719
112MAPK130.33478702
113CDK30.33377865
114CAMK2A0.33233380
115TRIM280.32686362
116RPS6KA50.32429268
117MARK20.30942043
118EPHB10.30627765
119CSNK1A10.30439248
120PRKG20.30289679
121RPS6KB10.30244343
122ROCK10.29995879
123MAP3K70.29764299
124RPS6KA20.28597751
125CAMK10.28531310
126PRKACA0.28443756
127NEK60.28407192
128PRKACB0.28235197
129CSNK1D0.27971934
130ZAK0.27858215
131TESK10.27761676
132PRKDC0.27491355
133MAP3K30.26888145
134PRKACG0.25238053
135SGK20.24533467
136CAMK2G0.23197015
137PRKCA0.23034579
138TEC0.22949151
139ATM0.22842621
140CDK50.22548813
141JAK20.22400883
142CSNK1E0.21894596
143MTOR0.21694584
144PRKCG0.21323227
145ADRBK20.20997591
146MAPK100.20444730
147RPS6KA30.20287518
148PRKD10.19967569
149MAPK140.19653813
150MARK10.19332505
151SGK10.19158259
152CHUK0.18711218
153CAMK2B0.18492042
154RET0.18452595
155MAPK90.18323864
156MAPK30.18216235
157GSK3A0.18170943

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.02832491
2Protein export_Homo sapiens_hsa030605.80855362
3Insulin secretion_Homo sapiens_hsa049113.49536948
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28333074
5Sulfur metabolism_Homo sapiens_hsa009203.11017241
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.85202820
7Vitamin B6 metabolism_Homo sapiens_hsa007502.78026996
8Vibrio cholerae infection_Homo sapiens_hsa051102.43274387
9Fatty acid elongation_Homo sapiens_hsa000622.03978924
10Type II diabetes mellitus_Homo sapiens_hsa049302.02158315
11Circadian rhythm_Homo sapiens_hsa047101.95686647
12Type I diabetes mellitus_Homo sapiens_hsa049401.81260487
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.79460888
14Selenocompound metabolism_Homo sapiens_hsa004501.74917711
15N-Glycan biosynthesis_Homo sapiens_hsa005101.71765166
16Propanoate metabolism_Homo sapiens_hsa006401.46985370
17Regulation of autophagy_Homo sapiens_hsa041401.46120615
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45974679
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45127702
20Synaptic vesicle cycle_Homo sapiens_hsa047211.44352888
21Cocaine addiction_Homo sapiens_hsa050301.40786213
22Lysosome_Homo sapiens_hsa041421.39861864
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.37242916
24Fatty acid metabolism_Homo sapiens_hsa012121.36901686
25Peroxisome_Homo sapiens_hsa041461.35524371
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34054785
27Taste transduction_Homo sapiens_hsa047421.32238754
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28134813
29Other glycan degradation_Homo sapiens_hsa005111.27901773
30GABAergic synapse_Homo sapiens_hsa047271.27510967
31Fatty acid degradation_Homo sapiens_hsa000711.23071995
32Collecting duct acid secretion_Homo sapiens_hsa049661.22745089
33Folate biosynthesis_Homo sapiens_hsa007901.22595926
34Amphetamine addiction_Homo sapiens_hsa050311.14948275
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13489129
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.12301823
37Circadian entrainment_Homo sapiens_hsa047131.09580020
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09454147
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08175796
40Glucagon signaling pathway_Homo sapiens_hsa049221.07320646
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05682128
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98014382
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97725600
44ABC transporters_Homo sapiens_hsa020100.95666565
45Morphine addiction_Homo sapiens_hsa050320.94508554
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94063343
47beta-Alanine metabolism_Homo sapiens_hsa004100.92693377
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90870496
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90003706
50Galactose metabolism_Homo sapiens_hsa000520.88386933
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88338237
52Serotonergic synapse_Homo sapiens_hsa047260.88250097
53Mineral absorption_Homo sapiens_hsa049780.88167903
54Dopaminergic synapse_Homo sapiens_hsa047280.88142322
55Pancreatic secretion_Homo sapiens_hsa049720.88090006
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87525591
57Thyroid hormone synthesis_Homo sapiens_hsa049180.85849346
58Cholinergic synapse_Homo sapiens_hsa047250.85253482
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80655303
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78986214
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76259488
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74135378
63Prion diseases_Homo sapiens_hsa050200.73626063
64Butanoate metabolism_Homo sapiens_hsa006500.72366538
65Parkinsons disease_Homo sapiens_hsa050120.70892267
66Retinol metabolism_Homo sapiens_hsa008300.70621781
67Sphingolipid metabolism_Homo sapiens_hsa006000.68629738
68Tryptophan metabolism_Homo sapiens_hsa003800.67191068
69Dorso-ventral axis formation_Homo sapiens_hsa043200.64798313
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63130294
71Insulin resistance_Homo sapiens_hsa049310.62333170
72Long-term potentiation_Homo sapiens_hsa047200.61353990
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60710149
74Prolactin signaling pathway_Homo sapiens_hsa049170.59916504
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58589710
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.57753871
77Chemical carcinogenesis_Homo sapiens_hsa052040.56751978
78Nicotine addiction_Homo sapiens_hsa050330.56066674
79Alcoholism_Homo sapiens_hsa050340.55749315
80Cardiac muscle contraction_Homo sapiens_hsa042600.54241074
81Linoleic acid metabolism_Homo sapiens_hsa005910.54158707
82Fructose and mannose metabolism_Homo sapiens_hsa000510.53605687
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53595690
84Glutathione metabolism_Homo sapiens_hsa004800.53312264
85Caffeine metabolism_Homo sapiens_hsa002320.52375354
86Renin secretion_Homo sapiens_hsa049240.52289788
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51117964
88Starch and sucrose metabolism_Homo sapiens_hsa005000.50985823
89Estrogen signaling pathway_Homo sapiens_hsa049150.50713292
90Arginine biosynthesis_Homo sapiens_hsa002200.49435519
91Salivary secretion_Homo sapiens_hsa049700.48968986
92Arachidonic acid metabolism_Homo sapiens_hsa005900.48383510
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48279068
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47572252
95Bile secretion_Homo sapiens_hsa049760.47374086
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46099885
97Phenylalanine metabolism_Homo sapiens_hsa003600.45530438
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.45443825
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43851761
100Nitrogen metabolism_Homo sapiens_hsa009100.43202582
101Glutamatergic synapse_Homo sapiens_hsa047240.41777346
102Insulin signaling pathway_Homo sapiens_hsa049100.41160986
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37780087
104cAMP signaling pathway_Homo sapiens_hsa040240.36429818
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34749601
106Inositol phosphate metabolism_Homo sapiens_hsa005620.34676932
107Oxidative phosphorylation_Homo sapiens_hsa001900.34162476
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33570460
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33325156
110Complement and coagulation cascades_Homo sapiens_hsa046100.32941167
111Lysine degradation_Homo sapiens_hsa003100.31519358
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30477002
113Phototransduction_Homo sapiens_hsa047440.29610387
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28058437
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27194937
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27144763
117Tyrosine metabolism_Homo sapiens_hsa003500.26830530
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26654535
119Alzheimers disease_Homo sapiens_hsa050100.25306250
120Histidine metabolism_Homo sapiens_hsa003400.24343723
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23370557
122Phagosome_Homo sapiens_hsa041450.23353946
123Olfactory transduction_Homo sapiens_hsa047400.21036885
124Protein digestion and absorption_Homo sapiens_hsa049740.18967035
125AMPK signaling pathway_Homo sapiens_hsa041520.18589791
126Oxytocin signaling pathway_Homo sapiens_hsa049210.18492465
127Ovarian steroidogenesis_Homo sapiens_hsa049130.17144216
128Rheumatoid arthritis_Homo sapiens_hsa053230.15876536
129mTOR signaling pathway_Homo sapiens_hsa041500.15474911
130Fat digestion and absorption_Homo sapiens_hsa049750.14528738
131Metabolic pathways_Homo sapiens_hsa011000.14052611
132Legionellosis_Homo sapiens_hsa051340.13687829
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.13058381
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12092529
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11672908
136Ether lipid metabolism_Homo sapiens_hsa005650.10332768
137Antigen processing and presentation_Homo sapiens_hsa046120.08653647
138Long-term depression_Homo sapiens_hsa047300.07932053

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