SCHIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.15742951
2presynaptic membrane assembly (GO:0097105)5.14287607
3presynaptic membrane organization (GO:0097090)4.93221926
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.74916721
5protein localization to synapse (GO:0035418)4.67218539
6pyrimidine nucleobase catabolic process (GO:0006208)4.66825219
7auditory behavior (GO:0031223)4.61949203
8vocalization behavior (GO:0071625)4.57654937
9synaptic vesicle exocytosis (GO:0016079)4.54245747
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.36543493
11glutamate receptor signaling pathway (GO:0007215)4.34602149
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23890685
13glutamate secretion (GO:0014047)4.18197545
14gamma-aminobutyric acid signaling pathway (GO:0007214)4.11376535
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06480520
16synaptic transmission, glutamatergic (GO:0035249)4.03358378
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.02474071
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00868416
19neuron-neuron synaptic transmission (GO:0007270)4.00825549
20neuron recognition (GO:0008038)3.97294295
21regulation of glutamate receptor signaling pathway (GO:1900449)3.95937613
22regulation of synaptic vesicle exocytosis (GO:2000300)3.93824731
23postsynaptic membrane organization (GO:0001941)3.92148886
24negative regulation of synaptic transmission, GABAergic (GO:0032229)3.91724642
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.91072802
26neurotransmitter-gated ion channel clustering (GO:0072578)3.83759656
27neuronal action potential propagation (GO:0019227)3.79290965
28negative regulation of neurotransmitter transport (GO:0051589)3.77206674
29response to auditory stimulus (GO:0010996)3.71163241
30cerebellar granule cell differentiation (GO:0021707)3.70905575
31nucleobase catabolic process (GO:0046113)3.70650144
32regulation of glutamate secretion (GO:0014048)3.69834839
33behavioral response to nicotine (GO:0035095)3.67729893
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65318762
35neuromuscular synaptic transmission (GO:0007274)3.62450932
36long-term synaptic potentiation (GO:0060291)3.57745214
37axon ensheathment in central nervous system (GO:0032291)3.55167479
38central nervous system myelination (GO:0022010)3.55167479
39neuronal ion channel clustering (GO:0045161)3.50479503
40axonal fasciculation (GO:0007413)3.50079164
41regulation of postsynaptic membrane potential (GO:0060078)3.48331617
42regulation of synaptic vesicle transport (GO:1902803)3.48174136
43establishment of mitochondrion localization (GO:0051654)3.43057109
44synaptic vesicle endocytosis (GO:0048488)3.41930531
45positive regulation of synapse maturation (GO:0090129)3.36359626
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35128492
47transmission of nerve impulse (GO:0019226)3.34508025
48positive regulation of synapse assembly (GO:0051965)3.32453689
49gamma-aminobutyric acid transport (GO:0015812)3.32150366
50startle response (GO:0001964)3.28082741
51positive regulation of neurotransmitter secretion (GO:0001956)3.26176769
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23710065
53regulation of dendritic spine morphogenesis (GO:0061001)3.21580442
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20758956
55behavioral response to cocaine (GO:0048148)3.18818653
56regulation of synaptic plasticity (GO:0048167)3.17623422
57regulation of neuronal synaptic plasticity (GO:0048168)3.16825157
58nonmotile primary cilium assembly (GO:0035058)3.15991357
59long-chain fatty acid biosynthetic process (GO:0042759)3.13921773
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.11717888
61locomotory exploration behavior (GO:0035641)3.11618333
62behavioral defense response (GO:0002209)3.08126302
63behavioral fear response (GO:0001662)3.08126302
64response to histamine (GO:0034776)3.07362725
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06951028
66exploration behavior (GO:0035640)3.06134181
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06072844
68regulation of neurotransmitter secretion (GO:0046928)3.05763202
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02627955
70regulation of voltage-gated calcium channel activity (GO:1901385)3.01947686
71regulation of synapse maturation (GO:0090128)3.01113153
72regulation of dendritic spine development (GO:0060998)3.00799633
73positive regulation of membrane potential (GO:0045838)2.99806590
74central nervous system projection neuron axonogenesis (GO:0021952)2.99738500
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.98994293
76dendrite development (GO:0016358)2.98614695
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95709246
78negative regulation of amino acid transport (GO:0051956)2.95300873
79regulation of cell communication by electrical coupling (GO:0010649)2.95279737
80membrane depolarization during action potential (GO:0086010)2.94957967
81synaptic vesicle maturation (GO:0016188)2.94875462
82neuronal action potential (GO:0019228)2.94543296
83fear response (GO:0042596)2.94541512
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92246173
85membrane depolarization (GO:0051899)2.90292578
86detection of calcium ion (GO:0005513)2.88771501
87mechanosensory behavior (GO:0007638)2.88589559
88cerebral cortex radially oriented cell migration (GO:0021799)2.88445214
89dendritic spine morphogenesis (GO:0060997)2.87844270
90C4-dicarboxylate transport (GO:0015740)2.87238843
91regulation of synapse assembly (GO:0051963)2.85391806
92neurotransmitter secretion (GO:0007269)2.85256529
93negative regulation of neurotransmitter secretion (GO:0046929)2.84868546
94ATP hydrolysis coupled proton transport (GO:0015991)2.84526374
95energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.84526374
96learning (GO:0007612)2.84510781
97long-term memory (GO:0007616)2.83792578
98cell migration in hindbrain (GO:0021535)2.82980217
99negative regulation of protein localization to cell surface (GO:2000009)2.82855263
100transferrin transport (GO:0033572)2.82081063
101regulation of vesicle fusion (GO:0031338)2.81137508
102dendritic spine organization (GO:0097061)2.81038815
103regulation of respiratory system process (GO:0044065)2.79219137
104neurotransmitter uptake (GO:0001504)2.78813641
105retinal ganglion cell axon guidance (GO:0031290)2.78078169
106synapse organization (GO:0050808)2.76662277
107regulation of neurotransmitter transport (GO:0051588)2.74245477
108positive regulation of neurotransmitter transport (GO:0051590)2.72069076
109adult walking behavior (GO:0007628)2.71884151
110innervation (GO:0060384)2.71435750
111cellular response to epinephrine stimulus (GO:0071872)2.70104253
112synapse assembly (GO:0007416)2.70098537
113cellular potassium ion homeostasis (GO:0030007)2.69990224
114membrane assembly (GO:0071709)2.69555559
115calcium-mediated signaling using intracellular calcium source (GO:0035584)2.68876582
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.68189492
117regulation of neurotransmitter uptake (GO:0051580)2.68180161
118regulation of synapse organization (GO:0050807)2.67983955
119negative regulation of synaptic transmission (GO:0050805)2.67920096
120regulation of synapse structural plasticity (GO:0051823)2.67005568
121regulation of synaptic transmission (GO:0050804)2.65860158
122neurotransmitter transport (GO:0006836)2.65583427
123dendrite morphogenesis (GO:0048813)2.62684901
124behavioral response to ethanol (GO:0048149)2.62048260
125detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58839442
126limb bud formation (GO:0060174)2.58589558
127adult behavior (GO:0030534)2.57605101
128positive regulation of mitochondrial fission (GO:0090141)2.56079309
129calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55175893
130regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.53032156
131central nervous system neuron axonogenesis (GO:0021955)2.51765848
132mitochondrion transport along microtubule (GO:0047497)2.51543844
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51543844
134positive regulation of dendritic spine development (GO:0060999)2.51086719
135synaptic transmission, cholinergic (GO:0007271)2.50908213
136potassium ion import (GO:0010107)2.49640555
137righting reflex (GO:0060013)2.48514664
138substrate-independent telencephalic tangential migration (GO:0021826)2.47390092
139substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.47390092
140positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47134254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.34236282
2GBX2_23144817_ChIP-Seq_PC3_Human4.51783917
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97707269
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88472528
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85784397
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.50207448
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50137770
8TAF15_26573619_Chip-Seq_HEK293_Human2.46298167
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43351787
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43351787
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43229890
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.38033808
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35369950
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35351151
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24957046
16REST_21632747_ChIP-Seq_MESCs_Mouse2.21370487
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17183818
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15268161
19VDR_22108803_ChIP-Seq_LS180_Human2.13844535
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12730535
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11418649
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09045718
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.97823784
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.96993002
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93540415
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92650824
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87957125
28P300_19829295_ChIP-Seq_ESCs_Human1.85832436
29* RARB_27405468_Chip-Seq_BRAIN_Mouse1.84187196
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83628822
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82541114
32FUS_26573619_Chip-Seq_HEK293_Human1.81122962
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79235903
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.77127718
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.75557506
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75342527
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.74850669
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73482651
39* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72631270
40AR_21572438_ChIP-Seq_LNCaP_Human1.71455611
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70042065
42DROSHA_22980978_ChIP-Seq_HELA_Human1.68677954
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68312888
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66940172
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.64818083
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63068229
47* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61852786
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52061250
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.50938555
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49704673
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46427622
52RNF2_27304074_Chip-Seq_NSC_Mouse1.45837988
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45048465
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41748448
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34181946
56ER_23166858_ChIP-Seq_MCF-7_Human1.33944191
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29194936
58STAT3_23295773_ChIP-Seq_U87_Human1.28262920
59AR_25329375_ChIP-Seq_VCAP_Human1.26335886
60* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26096788
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.22761675
62* TCF4_23295773_ChIP-Seq_U87_Human1.21058570
63ZNF274_21170338_ChIP-Seq_K562_Hela1.20637283
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.19730331
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.18401386
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18117453
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17668919
68* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16512938
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14676302
70CBP_20019798_ChIP-Seq_JUKART_Human1.14614054
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14614054
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14465731
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13648123
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.12999918
75BCAT_22108803_ChIP-Seq_LS180_Human1.12443968
76JUN_21703547_ChIP-Seq_K562_Human1.11677047
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.11055441
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10870337
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10487845
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09905539
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09850828
82RUNX2_22187159_ChIP-Seq_PCA_Human1.08500309
83EWS_26573619_Chip-Seq_HEK293_Human1.08216433
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08204281
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.07566114
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07151034
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07151034
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06887837
89* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06647137
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.06448140
91TP53_18474530_ChIP-ChIP_U2OS_Human1.05660737
92SOX9_26525672_Chip-Seq_HEART_Mouse1.05459279
93* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04305585
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.04196017
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03999006
96AHR_22903824_ChIP-Seq_MCF-7_Human1.03860721
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03343456
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02083257
99* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01163459
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.01153997
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00760423
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.00680305
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00113878
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.99333383
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99323778
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98813752
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98631822
108* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96707623
109* P53_22387025_ChIP-Seq_ESCs_Mouse0.96655947
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96625744
111TP53_16413492_ChIP-PET_HCT116_Human0.96219167
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96105756
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96018980
114* AR_19668381_ChIP-Seq_PC3_Human0.95796621
115IGF1R_20145208_ChIP-Seq_DFB_Human0.95776946
116* RING1B_27294783_Chip-Seq_NPCs_Mouse0.95408250
117* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93391422
118KDM2B_26808549_Chip-Seq_REH_Human0.93313306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.13575605
2MP0004859_abnormal_synaptic_plasticity4.82634295
3MP0004270_analgesia3.47156792
4MP0003635_abnormal_synaptic_transmissio3.44830819
5MP0009745_abnormal_behavioral_response3.10394649
6MP0001968_abnormal_touch/_nociception2.98248531
7MP0002063_abnormal_learning/memory/cond2.96791248
8MP0002736_abnormal_nociception_after2.89276299
9MP0002064_seizures2.88540304
10MP0002572_abnormal_emotion/affect_behav2.64766056
11MP0002272_abnormal_nervous_system2.61031949
12MP0009046_muscle_twitch2.52990854
13MP0002735_abnormal_chemical_nociception2.48089666
14MP0002734_abnormal_mechanical_nocicepti2.40581308
15MP0001486_abnormal_startle_reflex2.37437187
16MP0001440_abnormal_grooming_behavior2.32365205
17MP0000778_abnormal_nervous_system2.27871675
18MP0001529_abnormal_vocalization2.14570442
19MP0005423_abnormal_somatic_nervous2.07781378
20MP0002067_abnormal_sensory_capabilities2.02034291
21MP0001501_abnormal_sleep_pattern1.95996197
22MP0001905_abnormal_dopamine_level1.94840880
23MP0005171_absent_coat_pigmentation1.90908326
24MP0001188_hyperpigmentation1.82594397
25MP0002638_abnormal_pupillary_reflex1.81792974
26MP0006276_abnormal_autonomic_nervous1.76748756
27MP0002837_dystrophic_cardiac_calcinosis1.76139690
28MP0001970_abnormal_pain_threshold1.74433080
29MP0001984_abnormal_olfaction1.73649753
30MP0002184_abnormal_innervation1.72579915
31MP0002733_abnormal_thermal_nociception1.65283920
32MP0003329_amyloid_beta_deposits1.62339072
33MP0005386_behavior/neurological_phenoty1.59670141
34MP0004924_abnormal_behavior1.59670141
35MP0004142_abnormal_muscle_tone1.57849730
36MP0003787_abnormal_imprinting1.49087298
37MP0002557_abnormal_social/conspecific_i1.46634519
38MP0004145_abnormal_muscle_electrophysio1.45163221
39MP0000955_abnormal_spinal_cord1.44604012
40MP0000920_abnormal_myelination1.44296386
41MP0009780_abnormal_chondrocyte_physiolo1.42573328
42MP0004742_abnormal_vestibular_system1.42005430
43MP0002882_abnormal_neuron_morphology1.41993543
44MP0008569_lethality_at_weaning1.41262520
45MP0002102_abnormal_ear_morphology1.38710226
46MP0000751_myopathy1.36332769
47MP0002066_abnormal_motor_capabilities/c1.33278545
48MP0000566_synostosis1.30455182
49MP0005187_abnormal_penis_morphology1.29219687
50MP0004811_abnormal_neuron_physiology1.27712454
51MP0004885_abnormal_endolymph1.27547435
52MP0005646_abnormal_pituitary_gland1.27327033
53MP0001485_abnormal_pinna_reflex1.26278823
54MP0001502_abnormal_circadian_rhythm1.24126865
55MP0005409_darkened_coat_color1.21997865
56MP0003879_abnormal_hair_cell1.21521580
57MP0000569_abnormal_digit_pigmentation1.20911159
58MP0002822_catalepsy1.20393763
59MP0004133_heterotaxia1.17591427
60MP0005551_abnormal_eye_electrophysiolog1.17367192
61MP0004858_abnormal_nervous_system1.16285306
62MP0003122_maternal_imprinting1.16184406
63MP0003121_genomic_imprinting1.12857045
64MP0008789_abnormal_olfactory_epithelium1.12248793
65MP0002234_abnormal_pharynx_morphology1.10310221
66MP0001963_abnormal_hearing_physiology1.09856938
67MP0002229_neurodegeneration1.09615962
68MP0002152_abnormal_brain_morphology1.06052765
69MP0003631_nervous_system_phenotype1.04570610
70MP0003634_abnormal_glial_cell1.03861186
71MP0003633_abnormal_nervous_system1.03555706
72MP0001986_abnormal_taste_sensitivity1.03454477
73MP0005645_abnormal_hypothalamus_physiol1.02600569
74MP0002752_abnormal_somatic_nervous1.01553976
75MP0003136_yellow_coat_color0.98909043
76MP0004484_altered_response_of0.98880108
77MP0004085_abnormal_heartbeat0.98874214
78MP0004215_abnormal_myocardial_fiber0.98249815
79MP0004147_increased_porphyrin_level0.94649982
80MP0002876_abnormal_thyroid_physiology0.90966454
81MP0003632_abnormal_nervous_system0.90566129
82MP0002938_white_spotting0.89844962
83MP0006292_abnormal_olfactory_placode0.88121272
84MP0000026_abnormal_inner_ear0.86865250
85MP0005499_abnormal_olfactory_system0.86378949
86MP0005394_taste/olfaction_phenotype0.86378949
87MP0000749_muscle_degeneration0.85960760
88MP0001299_abnormal_eye_distance/0.83165720
89MP0005623_abnormal_meninges_morphology0.82317372
90MP0003137_abnormal_impulse_conducting0.82049536
91MP0000049_abnormal_middle_ear0.81945592
92MP0000631_abnormal_neuroendocrine_gland0.79202150
93MP0005195_abnormal_posterior_eye0.78192046
94MP0004036_abnormal_muscle_relaxation0.76189482
95MP0001664_abnormal_digestion0.75386884
96MP0003950_abnormal_plasma_membrane0.75256896
97MP0003119_abnormal_digestive_system0.73881330
98MP0002069_abnormal_eating/drinking_beha0.72996590
99MP0005167_abnormal_blood-brain_barrier0.72090478
100MP0003283_abnormal_digestive_organ0.71861184
101MP0002233_abnormal_nose_morphology0.71216478
102MP0004043_abnormal_pH_regulation0.68814948
103MP0003890_abnormal_embryonic-extraembry0.68805572
104MP0008877_abnormal_DNA_methylation0.68456272
105MP0006072_abnormal_retinal_apoptosis0.67418104
106MP0005620_abnormal_muscle_contractility0.67116570
107MP0003938_abnormal_ear_development0.66990044
108MP0002751_abnormal_autonomic_nervous0.66428147
109MP0003861_abnormal_nervous_system0.66061474
110MP0003690_abnormal_glial_cell0.65999260
111MP0005410_abnormal_fertilization0.63312245
112MP0001177_atelectasis0.63169290
113MP0001943_abnormal_respiration0.60338294
114MP0008874_decreased_physiological_sensi0.60284247
115MP0002909_abnormal_adrenal_gland0.58917823
116MP0010386_abnormal_urinary_bladder0.58016148
117MP0002653_abnormal_ependyma_morphology0.57045021
118MP0000013_abnormal_adipose_tissue0.55993823
119MP0005253_abnormal_eye_physiology0.54808259
120MP0008872_abnormal_physiological_respon0.54298126

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.58777624
2Epileptic encephalopathy (HP:0200134)5.02316021
3Hyperventilation (HP:0002883)4.86789143
4Atonic seizures (HP:0010819)4.68288634
5Myokymia (HP:0002411)4.39778656
6Focal seizures (HP:0007359)4.15473882
7Febrile seizures (HP:0002373)3.92756781
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.73346361
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.73346361
10Visual hallucinations (HP:0002367)3.52213417
11Broad-based gait (HP:0002136)3.51207298
12Dialeptic seizures (HP:0011146)3.46798589
13Absence seizures (HP:0002121)3.44023465
14Progressive cerebellar ataxia (HP:0002073)3.27348630
15Abnormality of the corticospinal tract (HP:0002492)3.18797738
16Cerebral inclusion bodies (HP:0100314)3.18348484
17Amblyopia (HP:0000646)3.11462344
18Sensory axonal neuropathy (HP:0003390)3.03715986
19Acute necrotizing encephalopathy (HP:0006965)2.99531877
20Neurofibrillary tangles (HP:0002185)2.95817519
21True hermaphroditism (HP:0010459)2.85862476
22Generalized tonic-clonic seizures (HP:0002069)2.85560949
23Termporal pattern (HP:0011008)2.78246700
24Insidious onset (HP:0003587)2.78246700
25Dysmetria (HP:0001310)2.73639763
26Gaze-evoked nystagmus (HP:0000640)2.71910213
27Supranuclear gaze palsy (HP:0000605)2.66742087
28Gait imbalance (HP:0002141)2.65363787
29Pheochromocytoma (HP:0002666)2.64968623
30Abnormal mitochondria in muscle tissue (HP:0008316)2.64953858
31Progressive macrocephaly (HP:0004481)2.63766467
32Excessive salivation (HP:0003781)2.61700707
33Drooling (HP:0002307)2.61700707
34Increased serum pyruvate (HP:0003542)2.60725465
35Abnormality of glycolysis (HP:0004366)2.60725465
36Thickened helices (HP:0000391)2.58641878
37Medial flaring of the eyebrow (HP:0010747)2.54605411
38Pancreatic fibrosis (HP:0100732)2.52911731
39Hemiplegia (HP:0002301)2.45146389
40Nephronophthisis (HP:0000090)2.42453835
41Neuroendocrine neoplasm (HP:0100634)2.40842594
42Epileptiform EEG discharges (HP:0011182)2.40550197
43Retinal dysplasia (HP:0007973)2.40174720
44Congenital primary aphakia (HP:0007707)2.39137338
45Pancreatic cysts (HP:0001737)2.38984680
46Dysdiadochokinesis (HP:0002075)2.37718060
47Molar tooth sign on MRI (HP:0002419)2.37258621
48Abnormality of midbrain morphology (HP:0002418)2.37258621
49Megalencephaly (HP:0001355)2.35809098
50Action tremor (HP:0002345)2.34454823
51Absent speech (HP:0001344)2.34194746
52Protruding tongue (HP:0010808)2.32884920
53Truncal ataxia (HP:0002078)2.29944441
54Mitochondrial inheritance (HP:0001427)2.29749402
55Nephrogenic diabetes insipidus (HP:0009806)2.27730950
56Scanning speech (HP:0002168)2.27534940
57Poor eye contact (HP:0000817)2.24822230
58Spastic gait (HP:0002064)2.18142059
59Acute encephalopathy (HP:0006846)2.17322879
60Muscle hypertrophy of the lower extremities (HP:0008968)2.16301487
61Vaginal atresia (HP:0000148)2.16066658
62Genital tract atresia (HP:0001827)2.15861400
63Abnormal hair whorl (HP:0010721)2.15195786
64Anxiety (HP:0000739)2.13322381
65Abnormality of the labia minora (HP:0012880)2.12352199
66Blue irides (HP:0000635)2.11385945
67Impaired vibration sensation in the lower limbs (HP:0002166)2.10450386
68Inability to walk (HP:0002540)2.10430632
69Delusions (HP:0000746)2.08528638
70Abnormality of the renal medulla (HP:0100957)2.06805004
71Chronic hepatic failure (HP:0100626)2.06190236
72Fetal akinesia sequence (HP:0001989)2.03721305
73Urinary bladder sphincter dysfunction (HP:0002839)2.02541670
74Lissencephaly (HP:0001339)2.02318692
75EEG with generalized epileptiform discharges (HP:0011198)2.00922413
76Leukodystrophy (HP:0002415)2.00481780
77Pachygyria (HP:0001302)1.99503778
78Hemiparesis (HP:0001269)1.99257006
79Ankle clonus (HP:0011448)1.97586713
80Lower limb muscle weakness (HP:0007340)1.97536566
81Exercise-induced muscle cramps (HP:0003710)1.97089081
82Split foot (HP:0001839)1.93915930
83Specific learning disability (HP:0001328)1.93437684
84Myotonia (HP:0002486)1.93073729
85Calf muscle hypertrophy (HP:0008981)1.92984911
86Increased CSF lactate (HP:0002490)1.92203140
87Postaxial hand polydactyly (HP:0001162)1.91951467
88Optic nerve hypoplasia (HP:0000609)1.91381875
89Abnormal eating behavior (HP:0100738)1.90983627
90Optic disc pallor (HP:0000543)1.90074924
91Abnormality of binocular vision (HP:0011514)1.89767649
92Diplopia (HP:0000651)1.89767649
93Left ventricular hypertrophy (HP:0001712)1.89647903
94Abnormality of salivation (HP:0100755)1.88942150
95Status epilepticus (HP:0002133)1.88660525
96Failure to thrive in infancy (HP:0001531)1.85984880
97Ulnar claw (HP:0001178)1.85067705
98Absent/shortened dynein arms (HP:0200106)1.83673994
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.83673994
100Limb dystonia (HP:0002451)1.82876250
101Genetic anticipation (HP:0003743)1.81468545
102Generalized myoclonic seizures (HP:0002123)1.79684550
103Hypsarrhythmia (HP:0002521)1.79558962
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79198069
105Progressive inability to walk (HP:0002505)1.78325305
106Morphological abnormality of the pyramidal tract (HP:0002062)1.77413280
107Incomplete penetrance (HP:0003829)1.77095514
108Poor coordination (HP:0002370)1.76740673
109Akinesia (HP:0002304)1.75851526
110Impaired social interactions (HP:0000735)1.75113352
111Abnormal social behavior (HP:0012433)1.75113352
112Gastroesophageal reflux (HP:0002020)1.75093031
113Intestinal atresia (HP:0011100)1.74459188
114Abnormality of the calf musculature (HP:0001430)1.74290659
115Abolished electroretinogram (ERG) (HP:0000550)1.72729197
116Sudden death (HP:0001699)1.72273665
117Hepatocellular necrosis (HP:0001404)1.71569197
118Peripheral hypomyelination (HP:0007182)1.70611102
119Depression (HP:0000716)1.70105966
120Prolonged QT interval (HP:0001657)1.69839335
121Urinary urgency (HP:0000012)1.69813139
122Broad foot (HP:0001769)1.69765607
123Hypoplasia of the brainstem (HP:0002365)1.69648378
124Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69648378
125Cystic liver disease (HP:0006706)1.69521260
126Exotropia (HP:0000577)1.68463878
127X-linked dominant inheritance (HP:0001423)1.67957070
128Type II lissencephaly (HP:0007260)1.67872598
129Syncope (HP:0001279)1.67708895
130Polyphagia (HP:0002591)1.66901070
131Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65837666
132Abnormal ciliary motility (HP:0012262)1.65598720
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.65220969
134Oligodactyly (hands) (HP:0001180)1.63639817
135Postaxial foot polydactyly (HP:0001830)1.61032628
136Supernumerary spleens (HP:0009799)1.60285104
137Occipital encephalocele (HP:0002085)1.59575853
138Amyotrophic lateral sclerosis (HP:0007354)1.59231264
139Cutaneous finger syndactyly (HP:0010554)1.58467319
140Anencephaly (HP:0002323)1.58114367
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57600657
142Hypoplasia of the corpus callosum (HP:0002079)1.56849546
143Sleep apnea (HP:0010535)1.56524432
144Esotropia (HP:0000565)1.56016640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.02402470
2EPHA44.38484603
3NTRK33.21718687
4PLK22.69002410
5PRPF4B2.66060563
6CDK192.62467083
7MAP2K72.54358692
8OXSR12.48438824
9MAP3K42.48203901
10MAP3K122.20686133
11FRK2.03506635
12DAPK21.97783469
13MARK11.94862171
14MAP4K21.94607917
15STK391.90669453
16PNCK1.75174061
17MINK11.74888469
18MAP3K91.74719100
19RIPK41.70855043
20GRK51.70313056
21BCR1.63477871
22TNIK1.60818295
23DAPK11.56078417
24AKT31.49249892
25FGR1.48884309
26PTK2B1.48701970
27NME11.46049609
28CAMK2B1.44703345
29MAP2K41.42145811
30MAPK151.42040010
31ARAF1.41887083
32MAPK131.39139258
33BMPR21.37619641
34CAMK2A1.33881206
35PAK61.24920947
36KSR11.24307926
37EPHB21.19289360
38SGK2231.19017510
39SGK4941.19017510
40NTRK21.16822282
41CDK51.15975225
42CSNK1G11.03395108
43CAMK2D1.02868381
44SIK31.01013109
45UHMK10.99901524
46PRKCG0.99881906
47INSRR0.95948332
48PKN10.91809031
49CCNB10.91774847
50NTRK10.90458954
51DYRK1A0.88709264
52TIE10.88292483
53CDK180.88157633
54CDK140.87296276
55ERBB30.87186962
56DYRK30.86760609
57ROCK20.85822650
58BCKDK0.83711261
59PHKG20.83619163
60PHKG10.83619163
61KSR20.83417586
62PRKCE0.83007392
63DYRK1B0.82804172
64CDK150.82000223
65GRK70.81333611
66BRAF0.80152646
67EPHA30.77637700
68WNK40.75105637
69MUSK0.73263608
70NEK60.72259557
71CSNK1G20.70929806
72CDK80.70855595
73CDK11A0.70664884
74SGK20.68765336
75FLT30.68482430
76GRK10.67410340
77CAMK2G0.66929410
78NUAK10.65890893
79MKNK10.64091476
80MARK20.63738772
81MYLK0.62243366
82MAP3K130.61652795
83ADRBK10.61644757
84CAMK40.60493946
85FES0.59239563
86SGK10.58601640
87WNK10.57735983
88CAMKK10.57732042
89MAPKAPK50.57617914
90VRK10.56544306
91DAPK30.56200433
92PAK30.56184823
93ADRBK20.56016105
94SIK20.54364103
95OBSCN0.53702326
96WNK30.51877731
97ROCK10.51077040
98PRKD30.50603122
99CAMKK20.49765885
100BMPR1B0.48778854
101PINK10.48352890
102CDK30.47693918
103GRK60.46977004
104TGFBR10.46198551
105TRIM280.44585359
106CSNK1G30.44104313
107KIT0.42719004
108CAMK10.42246080
109PRKACA0.41406362
110DYRK20.41389408
111TYRO30.40659763
112WEE10.40249361
113STK38L0.40098508
114FER0.40066290
115PIK3CA0.39172287
116RAF10.38627257
117MAPK120.38399042
118CSNK1D0.37862936
119PRKG10.37842123
120STK110.37301140
121PRKCZ0.37066205
122MAPK70.37056902
123TSSK60.36902255
124PRKCH0.36530508
125LIMK10.36311260
126MET0.35320421
127FGFR20.35297281
128RPS6KA30.35089107
129PRKCQ0.32746833
130CSNK1A1L0.32276095
131MKNK20.31427078
132PDK30.31311253

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.17715382
2Synaptic vesicle cycle_Homo sapiens_hsa047213.17028969
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86454091
4Collecting duct acid secretion_Homo sapiens_hsa049662.76870894
5Circadian entrainment_Homo sapiens_hsa047132.59731655
6Long-term potentiation_Homo sapiens_hsa047202.57800865
7Oxidative phosphorylation_Homo sapiens_hsa001902.56625571
8Glutamatergic synapse_Homo sapiens_hsa047242.51974455
9Morphine addiction_Homo sapiens_hsa050322.44881102
10GABAergic synapse_Homo sapiens_hsa047272.41020003
11Amphetamine addiction_Homo sapiens_hsa050312.38397446
12Olfactory transduction_Homo sapiens_hsa047402.33975344
13Taste transduction_Homo sapiens_hsa047422.11627839
14Dopaminergic synapse_Homo sapiens_hsa047281.98975187
15Serotonergic synapse_Homo sapiens_hsa047261.96073123
16Salivary secretion_Homo sapiens_hsa049701.93575062
17Alzheimers disease_Homo sapiens_hsa050101.93009033
18Long-term depression_Homo sapiens_hsa047301.84433865
19Parkinsons disease_Homo sapiens_hsa050121.79476010
20Cardiac muscle contraction_Homo sapiens_hsa042601.76962377
21Vibrio cholerae infection_Homo sapiens_hsa051101.76124751
22Renin secretion_Homo sapiens_hsa049241.74763765
23Calcium signaling pathway_Homo sapiens_hsa040201.65327791
24Axon guidance_Homo sapiens_hsa043601.60848258
25Insulin secretion_Homo sapiens_hsa049111.54671191
26Butanoate metabolism_Homo sapiens_hsa006501.53574154
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51057544
28Oxytocin signaling pathway_Homo sapiens_hsa049211.50463939
29Gastric acid secretion_Homo sapiens_hsa049711.49775298
30Cholinergic synapse_Homo sapiens_hsa047251.45548251
31Phototransduction_Homo sapiens_hsa047441.39118026
32Nitrogen metabolism_Homo sapiens_hsa009101.37639354
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35835887
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35787035
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33195296
36Propanoate metabolism_Homo sapiens_hsa006401.33108077
37Cocaine addiction_Homo sapiens_hsa050301.32802174
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32200055
39Huntingtons disease_Homo sapiens_hsa050161.32088331
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.30740654
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25311618
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20328157
43Gap junction_Homo sapiens_hsa045401.13851650
44cAMP signaling pathway_Homo sapiens_hsa040241.12706568
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05001818
46GnRH signaling pathway_Homo sapiens_hsa049121.04990889
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03185820
48Protein export_Homo sapiens_hsa030601.02256398
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.00701995
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99409720
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95418887
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94690049
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93074864
54Dilated cardiomyopathy_Homo sapiens_hsa054140.91321233
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91285025
56Rheumatoid arthritis_Homo sapiens_hsa053230.90057059
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89309456
58Melanogenesis_Homo sapiens_hsa049160.87502191
59ErbB signaling pathway_Homo sapiens_hsa040120.84456717
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83338726
61Fatty acid elongation_Homo sapiens_hsa000620.81990229
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81397290
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79238479
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78572513
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78269220
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74683461
67Ether lipid metabolism_Homo sapiens_hsa005650.72571572
68Peroxisome_Homo sapiens_hsa041460.72472294
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71889291
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71688864
71Hippo signaling pathway_Homo sapiens_hsa043900.68930759
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68815725
73Ras signaling pathway_Homo sapiens_hsa040140.68316839
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67069519
75Estrogen signaling pathway_Homo sapiens_hsa049150.66984357
76Arginine and proline metabolism_Homo sapiens_hsa003300.66163523
77beta-Alanine metabolism_Homo sapiens_hsa004100.65012484
78Basal cell carcinoma_Homo sapiens_hsa052170.63246611
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.61068323
80Pancreatic secretion_Homo sapiens_hsa049720.61016567
81MAPK signaling pathway_Homo sapiens_hsa040100.60243278
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60223525
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59301920
84Steroid biosynthesis_Homo sapiens_hsa001000.58771916
85Linoleic acid metabolism_Homo sapiens_hsa005910.58695049
86Glioma_Homo sapiens_hsa052140.57864008
87Phagosome_Homo sapiens_hsa041450.57815071
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56174708
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55282967
90Oocyte meiosis_Homo sapiens_hsa041140.55266943
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54034037
92Type II diabetes mellitus_Homo sapiens_hsa049300.51311286
93Choline metabolism in cancer_Homo sapiens_hsa052310.49681011
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.49264780
95Tryptophan metabolism_Homo sapiens_hsa003800.48213158
96Fatty acid metabolism_Homo sapiens_hsa012120.45943519
97Wnt signaling pathway_Homo sapiens_hsa043100.45147121
98Histidine metabolism_Homo sapiens_hsa003400.45074962
99Bile secretion_Homo sapiens_hsa049760.45040117
100Rap1 signaling pathway_Homo sapiens_hsa040150.44584675
101Pyruvate metabolism_Homo sapiens_hsa006200.44361724
102Circadian rhythm_Homo sapiens_hsa047100.44215541
103Renal cell carcinoma_Homo sapiens_hsa052110.43604233
104Dorso-ventral axis formation_Homo sapiens_hsa043200.42059056
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41992007
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41938697
107African trypanosomiasis_Homo sapiens_hsa051430.40560941
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.40313422
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39505269
110Alcoholism_Homo sapiens_hsa050340.39222787
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38672753
112Inositol phosphate metabolism_Homo sapiens_hsa005620.38141898
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.36607780
114Tight junction_Homo sapiens_hsa045300.35172348
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31222181
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30761230
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30684350
118Ovarian steroidogenesis_Homo sapiens_hsa049130.29933042
119Regulation of autophagy_Homo sapiens_hsa041400.29135258
120Hedgehog signaling pathway_Homo sapiens_hsa043400.27889378
121ABC transporters_Homo sapiens_hsa020100.27634483
122Thyroid hormone synthesis_Homo sapiens_hsa049180.26281321
123Sphingolipid metabolism_Homo sapiens_hsa006000.25439921
124Glucagon signaling pathway_Homo sapiens_hsa049220.24037020
125VEGF signaling pathway_Homo sapiens_hsa043700.23774132
126Melanoma_Homo sapiens_hsa052180.23340480
127Prion diseases_Homo sapiens_hsa050200.22918586

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »