SCIMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.72958186
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.58574738
3immunoglobulin mediated immune response (GO:0016064)5.45832220
4cytidine deamination (GO:0009972)5.42179551
5cytidine metabolic process (GO:0046087)5.42179551
6cytidine catabolic process (GO:0006216)5.42179551
7antigen processing and presentation of endogenous antigen (GO:0019883)5.15015524
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.00593564
9modulation by symbiont of host immune response (GO:0052553)5.00593564
10positive regulation by symbiont of host defense response (GO:0052509)5.00593564
11modulation by symbiont of host defense response (GO:0052031)5.00593564
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.00593564
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.00593564
14cellular response to zinc ion (GO:0071294)4.84913442
15regulation of B cell receptor signaling pathway (GO:0050855)4.71460602
16positive regulation of interferon-alpha production (GO:0032727)4.61105720
17respiratory burst (GO:0045730)4.45572846
18regulation of interferon-alpha production (GO:0032647)4.32871393
19positive regulation of type 2 immune response (GO:0002830)4.27377293
20granulocyte activation (GO:0036230)4.19706043
21B cell mediated immunity (GO:0019724)4.19090995
22neutrophil activation (GO:0042119)4.18087891
23fucose catabolic process (GO:0019317)4.14694612
24L-fucose metabolic process (GO:0042354)4.14694612
25L-fucose catabolic process (GO:0042355)4.14694612
26regulation of dendritic cell antigen processing and presentation (GO:0002604)4.13329319
27cellular response to exogenous dsRNA (GO:0071360)4.11738247
28macrophage activation involved in immune response (GO:0002281)4.11540019
29pyrimidine ribonucleoside catabolic process (GO:0046133)4.03367510
30production of molecular mediator involved in inflammatory response (GO:0002532)4.03117593
31positive regulation of gamma-delta T cell activation (GO:0046645)4.02599388
32positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.00099058
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98351620
34negative regulation of cell killing (GO:0031342)3.98351620
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.95755104
36response to peptidoglycan (GO:0032494)3.93718466
37regulation of interferon-beta biosynthetic process (GO:0045357)3.91083620
38natural killer cell mediated immunity (GO:0002228)3.89911190
39natural killer cell mediated cytotoxicity (GO:0042267)3.89911190
40activated T cell proliferation (GO:0050798)3.88431694
41regulation of gamma-delta T cell activation (GO:0046643)3.84037270
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83664312
43positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.82259145
44B cell receptor signaling pathway (GO:0050853)3.80793684
45positive regulation of antigen processing and presentation (GO:0002579)3.80786326
46cellular response to type I interferon (GO:0071357)3.76306203
47type I interferon signaling pathway (GO:0060337)3.76306203
48positive regulation of cellular amide metabolic process (GO:0034250)3.74905731
49positive regulation of mast cell activation (GO:0033005)3.73229466
50response to type I interferon (GO:0034340)3.71738281
51positive regulation of mast cell activation involved in immune response (GO:0033008)3.69941273
52positive regulation of mast cell degranulation (GO:0043306)3.69941273
53positive regulation of macrophage cytokine production (GO:0060907)3.69262813
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.67698674
55regulation of T-helper 1 cell differentiation (GO:0045625)3.65101255
56germinal center formation (GO:0002467)3.64773610
57behavioral response to nicotine (GO:0035095)3.61717648
58hydrogen peroxide biosynthetic process (GO:0050665)3.60666930
59regulation of B cell differentiation (GO:0045577)3.58062967
60cellular response to interferon-beta (GO:0035458)3.55483310
61interferon-gamma-mediated signaling pathway (GO:0060333)3.54302357
62cellular response to interferon-alpha (GO:0035457)3.52833784
63myeloid cell activation involved in immune response (GO:0002275)3.52492171
64lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51607727
65leukocyte aggregation (GO:0070486)3.51353822
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51106157
67positive regulation of defense response to virus by host (GO:0002230)3.49347100
68regulation of RIG-I signaling pathway (GO:0039535)3.49323288
69microglial cell activation (GO:0001774)3.48537831
70regulation of interferon-gamma biosynthetic process (GO:0045072)3.46667196
71myeloid dendritic cell differentiation (GO:0043011)3.46182348
72DNA deamination (GO:0045006)3.42661997
73response to host immune response (GO:0052572)3.41906506
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.41906506
75positive regulation of monocyte chemotaxis (GO:0090026)3.41101328
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.40343642
77defense response to protozoan (GO:0042832)3.39999077
78detection of bacterium (GO:0016045)3.38873682
79T-helper 1 type immune response (GO:0042088)3.38430124
80detection of other organism (GO:0098543)3.37394287
81leukocyte mediated cytotoxicity (GO:0001909)3.37127145
82regulation of T-helper 2 cell differentiation (GO:0045628)3.36679665
83negative thymic T cell selection (GO:0045060)3.34793313
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34742638
85myeloid dendritic cell activation (GO:0001773)3.31677749
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31103183
87mast cell activation (GO:0045576)3.28936634
88negative regulation of T cell mediated immunity (GO:0002710)3.27036235
89positive regulation of interferon-beta production (GO:0032728)3.25801751
90negative regulation of myeloid cell apoptotic process (GO:0033033)3.25446323
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25405549
92negative regulation of interleukin-12 production (GO:0032695)3.22975502
93negative T cell selection (GO:0043383)3.22239527
94regulation of alpha-beta T cell proliferation (GO:0046640)3.22016612
95regulation of antigen processing and presentation (GO:0002577)3.20897025
96interferon-gamma production (GO:0032609)3.18873876
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17586188
98positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17553130
99positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.16402267
100macrophage activation (GO:0042116)3.16141655
101positive regulation of T cell mediated cytotoxicity (GO:0001916)3.15980013
102regulation of type 2 immune response (GO:0002828)3.15081124
103reactive oxygen species biosynthetic process (GO:1903409)3.14976304
104regulation of T cell mediated cytotoxicity (GO:0001914)3.14654487
105regulation of gamma-delta T cell differentiation (GO:0045586)3.12718797
106positive regulation of B cell differentiation (GO:0045579)3.09617947
107positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08365212
108positive regulation of cytokine biosynthetic process (GO:0042108)3.06028470
109myeloid leukocyte activation (GO:0002274)3.05595597
110positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.05530523
111positive regulation of natural killer cell differentiation (GO:0032825)3.05175399
112positive regulation of interleukin-12 production (GO:0032735)3.03515278
113purinergic nucleotide receptor signaling pathway (GO:0035590)3.03356369
114lymphocyte mediated immunity (GO:0002449)3.03282217
115cellular extravasation (GO:0045123)3.01275811
116negative regulation of lymphocyte mediated immunity (GO:0002707)3.01150128
117response to interferon-alpha (GO:0035455)3.00261430
118superoxide anion generation (GO:0042554)2.99806766
119positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.99653327
120regulation of mast cell activation (GO:0033003)2.99396491
121detection of molecule of bacterial origin (GO:0032490)2.98430557
122response to host (GO:0075136)2.97847944
123response to host defenses (GO:0052200)2.97847944
124response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97847944
125response to protozoan (GO:0001562)2.97635377
126adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.95319353
127positive regulation of B cell proliferation (GO:0030890)2.94167987
128positive thymic T cell selection (GO:0045059)2.92468102
129regulation of mast cell degranulation (GO:0043304)2.87271453
130cellular response to interleukin-15 (GO:0071350)2.84743519
131regulation of hypersensitivity (GO:0002883)2.84344080
132T cell costimulation (GO:0031295)2.83215912
133tolerance induction (GO:0002507)2.82445408
134positive regulation of immunoglobulin mediated immune response (GO:0002891)2.81077426
135positive regulation of B cell mediated immunity (GO:0002714)2.81077426
136T cell migration (GO:0072678)2.80407668
137regulation of mast cell activation involved in immune response (GO:0033006)2.79908473
138negative regulation of mast cell activation (GO:0033004)2.79881496
139detection of external biotic stimulus (GO:0098581)2.79726055
140lymphocyte costimulation (GO:0031294)2.79417409
141positive regulation of T-helper 1 type immune response (GO:0002827)2.78732028
142regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77517189
143regulation of memory T cell differentiation (GO:0043380)2.77228891
144antigen receptor-mediated signaling pathway (GO:0050851)2.70774470
145positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70018550
146cellular response to interferon-gamma (GO:0071346)2.67152645
147regulation of germinal center formation (GO:0002634)2.66884696
148CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.65686355
149response to interleukin-15 (GO:0070672)2.65214428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.98197592
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.56451620
3BP1_19119308_ChIP-ChIP_Hs578T_Human7.35033336
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.36664835
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78978306
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.38350419
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.29738399
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.55021454
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.47605557
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24990768
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24582285
12ZNF274_21170338_ChIP-Seq_K562_Hela3.05392860
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97929943
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89405727
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.84222044
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.83688684
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.73779842
18EZH2_22144423_ChIP-Seq_EOC_Human2.70495843
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40727953
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37606700
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33006099
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.18660828
23* SPI1_23547873_ChIP-Seq_NB4_Human2.16970557
24MYB_26560356_Chip-Seq_TH2_Human1.92053312
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85519519
26VDR_22108803_ChIP-Seq_LS180_Human1.74200388
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73025317
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72494516
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70529851
30RUNX_20019798_ChIP-Seq_JUKART_Human1.69239961
31MAF_26560356_Chip-Seq_TH1_Human1.67329504
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66872304
33CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66869693
34VDR_24763502_ChIP-Seq_THP-1_Human1.60625182
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59536550
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.57757217
37MYB_26560356_Chip-Seq_TH1_Human1.54761077
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53073786
39SPI1_23127762_ChIP-Seq_K562_Human1.50904779
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.48451744
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47166702
42VDR_24787735_ChIP-Seq_THP-1_Human1.46553804
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45012830
44PU_27001747_Chip-Seq_BMDM_Mouse1.42870801
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42786518
46CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42499777
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.42242923
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40652127
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40480424
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40363019
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38991773
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36098487
53SCL_19346495_ChIP-Seq_HPC-7_Human1.35282499
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35162917
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33571233
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31952539
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31820069
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30177996
59TAF2_19829295_ChIP-Seq_ESCs_Human1.29872550
60IRF1_19129219_ChIP-ChIP_H3396_Human1.29010324
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25871073
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25129451
63GATA3_27048872_Chip-Seq_THYMUS_Human1.25124905
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22535293
65ERA_21632823_ChIP-Seq_H3396_Human1.20938854
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20127694
67NANOG_20526341_ChIP-Seq_ESCs_Human1.19794377
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18222576
69ER_23166858_ChIP-Seq_MCF-7_Human1.17294437
70GATA3_26560356_Chip-Seq_TH2_Human1.15195601
71RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13178550
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12175758
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10303224
74VDR_21846776_ChIP-Seq_THP-1_Human1.09896102
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09795737
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08635455
77TP53_22573176_ChIP-Seq_HFKS_Human1.07977801
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07490923
79UTX_26944678_Chip-Seq_JUKART_Human1.06971217
80MYC_19829295_ChIP-Seq_ESCs_Human1.05878688
81BCAT_22108803_ChIP-Seq_LS180_Human1.05216398
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.04492449
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04492449
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04371669
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04362566
86DROSHA_22980978_ChIP-Seq_HELA_Human1.03573992
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03507378
88E2F7_22180533_ChIP-Seq_HELA_Human1.03008842
89OCT4_20526341_ChIP-Seq_ESCs_Human1.02875555
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01324439
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01228998
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.00655072
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00506404
94E2F1_20622854_ChIP-Seq_HELA_Human1.00036621
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99404527
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98712520
97GATA1_22025678_ChIP-Seq_K562_Human0.98417149
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97921530
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97021133
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95325100
101TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95092661
102FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94927458
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94844980
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94522323
105MYC_22102868_ChIP-Seq_BL_Human0.93999976
106BCOR_27268052_Chip-Seq_Bcells_Human0.93678416
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93090896
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92934304
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92934304
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92252273
111VDR_23849224_ChIP-Seq_CD4+_Human0.91445229
112MAF_26560356_Chip-Seq_TH2_Human0.89933204
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89904706
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89244722
115RAC3_21632823_ChIP-Seq_H3396_Human0.88718204
116NANOG_19829295_ChIP-Seq_ESCs_Human0.87319867
117SOX2_19829295_ChIP-Seq_ESCs_Human0.87319867
118EGR1_19032775_ChIP-ChIP_M12_Human0.87151493
119HOXB7_26014856_ChIP-Seq_BT474_Human0.86430829
120PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80496989
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77466340
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.65309389
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.64743052
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64206682
125SPI1_20517297_ChIP-Seq_HL60_Human0.63801256
126HOXB4_20404135_ChIP-ChIP_EML_Mouse0.62631532
127TCF7_22412390_ChIP-Seq_EML_Mouse0.62474842
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61259840
129SMRT_27268052_Chip-Seq_Bcells_Human0.60949019
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.60317691
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.58290805
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57900320
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.57128578
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.57120477
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52758587
136BCL6_27268052_Chip-Seq_Bcells_Human0.52649225
137CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.52293689
138SOX2_20726797_ChIP-Seq_SW620_Human0.51414482
139CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.50467167
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.50204970
141PPARA_22158963_ChIP-Seq_LIVER_Mouse0.49834724
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.49444520
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.49108231
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.47322189
145CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.47093744
146GATA3_26560356_Chip-Seq_TH1_Human0.46857012
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.46798484
148P300_27268052_Chip-Seq_Bcells_Human0.45306710
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.45271521
150NOTCH1_21737748_ChIP-Seq_TLL_Human0.44632500
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.44473777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.00221414
2MP0002148_abnormal_hypersensitivity_rea4.08844595
3MP0009785_altered_susceptibility_to3.78621005
4MP0001790_abnormal_immune_system3.71520137
5MP0005387_immune_system_phenotype3.71520137
6MP0005671_abnormal_response_to3.71254267
7MP0003436_decreased_susceptibility_to3.67980827
8MP0005000_abnormal_immune_tolerance3.66794702
9MP0000685_abnormal_immune_system3.44616111
10MP0001800_abnormal_humoral_immune3.43912399
11MP0005025_abnormal_response_to3.20141960
12MP0003724_increased_susceptibility_to3.19835939
13MP0002452_abnormal_antigen_presenting3.18567618
14MP0002419_abnormal_innate_immunity3.17535728
15MP0006082_CNS_inflammation3.16044118
16MP0003303_peritoneal_inflammation3.12666118
17MP0002723_abnormal_immune_serum3.00127767
18MP0001986_abnormal_taste_sensitivity2.83091664
19MP0001853_heart_inflammation2.73811376
20MP0001819_abnormal_immune_cell2.67826914
21MP0004510_myositis2.67620453
22MP0002420_abnormal_adaptive_immunity2.66080446
23MP0000569_abnormal_digit_pigmentation2.11059546
24MP0002405_respiratory_system_inflammati2.08523080
25MP0009764_decreased_sensitivity_to2.02452354
26MP0001845_abnormal_inflammatory_respons1.98696775
27MP0000716_abnormal_immune_system1.97437218
28MP0001533_abnormal_skeleton_physiology1.90957546
29MP0002398_abnormal_bone_marrow1.90937980
30MP0005310_abnormal_salivary_gland1.89415304
31MP0005464_abnormal_platelet_physiology1.73462813
32MP0008469_abnormal_protein_level1.71210340
33MP0004947_skin_inflammation1.70176517
34MP0008875_abnormal_xenobiotic_pharmacok1.69657359
35MP0002006_tumorigenesis1.69354057
36MP0003448_altered_tumor_morphology1.69343787
37MP0003136_yellow_coat_color1.66238129
38MP0000689_abnormal_spleen_morphology1.63936476
39MP0010155_abnormal_intestine_physiology1.61996735
40MP0002429_abnormal_blood_cell1.56756745
41MP0001873_stomach_inflammation1.55623436
42MP0009333_abnormal_splenocyte_physiolog1.49613174
43MP0002722_abnormal_immune_system1.45830581
44MP0005058_abnormal_lysosome_morphology1.42601809
45MP0003191_abnormal_cellular_cholesterol1.42405643
46MP0003075_altered_response_to1.42383649
47MP0004381_abnormal_hair_follicle1.38585053
48MP0000343_altered_response_to1.38571576
49MP0005645_abnormal_hypothalamus_physiol1.37702759
50MP0000858_altered_metastatic_potential1.37475741
51MP0008872_abnormal_physiological_respon1.34739939
52MP0003763_abnormal_thymus_physiology1.31811415
53MP0008877_abnormal_DNA_methylation1.31439389
54MP0004782_abnormal_surfactant_physiolog1.27462161
55MP0002998_abnormal_bone_remodeling1.23006187
56MP0002166_altered_tumor_susceptibility1.22111209
57MP0005075_abnormal_melanosome_morpholog1.19306661
58MP0004142_abnormal_muscle_tone1.17079912
59MP0009840_abnormal_foam_cell1.15649470
60MP0002933_joint_inflammation1.14423346
61MP0003011_delayed_dark_adaptation1.12795068
62MP0004742_abnormal_vestibular_system1.12374703
63MP0005166_decreased_susceptibility_to1.12356568
64MP0001663_abnormal_digestive_system1.12194139
65MP0002928_abnormal_bile_duct1.11605746
66MP0002653_abnormal_ependyma_morphology1.10173130
67MP0001968_abnormal_touch/_nociception1.09153313
68MP0003646_muscle_fatigue1.09062810
69MP0005084_abnormal_gallbladder_morpholo1.06671113
70MP0000015_abnormal_ear_pigmentation1.06632935
71MP0009763_increased_sensitivity_to1.01073116
72MP0005451_abnormal_body_composition1.01035939
73MP0003186_abnormal_redox_activity0.99997737
74MP0003183_abnormal_peptide_metabolism0.99324921
75MP0000372_irregular_coat_pigmentation0.99148426
76MP0002163_abnormal_gland_morphology0.97416940
77MP0005551_abnormal_eye_electrophysiolog0.90573071
78MP0009046_muscle_twitch0.89755403
79MP0002102_abnormal_ear_morphology0.86368772
80MP0004043_abnormal_pH_regulation0.85836543
81MP0003195_calcinosis0.84913202
82MP0000604_amyloidosis0.84148364
83MP0005167_abnormal_blood-brain_barrier0.83911579
84MP0003690_abnormal_glial_cell0.83846664
85MP0003806_abnormal_nucleotide_metabolis0.82922330
86MP0003172_abnormal_lysosome_physiology0.82267708
87MP0009745_abnormal_behavioral_response0.80667477
88MP0003300_gastrointestinal_ulcer0.79799723
89MP0005390_skeleton_phenotype0.78561850
90MP0003866_abnormal_defecation0.77118525
91MP0001545_abnormal_hematopoietic_system0.76854378
92MP0005397_hematopoietic_system_phenotyp0.76854378
93MP0005164_abnormal_response_to0.76408285
94MP0002638_abnormal_pupillary_reflex0.74341157
95MP0003252_abnormal_bile_duct0.73915124
96MP0004130_abnormal_muscle_cell0.72514036
97MP0002136_abnormal_kidney_physiology0.72215246
98MP0003828_pulmonary_edema0.71315124
99MP0002138_abnormal_hepatobiliary_system0.70746378
100MP0002277_abnormal_respiratory_mucosa0.69873899
101MP0002132_abnormal_respiratory_system0.69111881
102MP0001919_abnormal_reproductive_system0.68674359
103MP0000703_abnormal_thymus_morphology0.68396020
104MP0008961_abnormal_basal_metabolism0.65265785
105MP0000249_abnormal_blood_vessel0.64192169
106MP0005584_abnormal_enzyme/coenzyme_acti0.64072391
107MP0010307_abnormal_tumor_latency0.64058178
108MP0002095_abnormal_skin_pigmentation0.62728385
109MP0002019_abnormal_tumor_incidence0.62067788
110MP0004883_abnormal_blood_vessel0.61789810
111MP0010386_abnormal_urinary_bladder0.61693701
112MP0002735_abnormal_chemical_nociception0.60632181
113MP0009278_abnormal_bone_marrow0.60239202
114MP0005381_digestive/alimentary_phenotyp0.57660466
115MP0001501_abnormal_sleep_pattern0.57146870
116MP0005379_endocrine/exocrine_gland_phen0.56696353
117MP0000920_abnormal_myelination0.55556614
118MP0003045_fibrosis0.54816805
119MP0002693_abnormal_pancreas_physiology0.54708680
120MP0000470_abnormal_stomach_morphology0.54699006
121MP0001851_eye_inflammation0.54433988
122MP0000230_abnormal_systemic_arterial0.53142752
123MP0005423_abnormal_somatic_nervous0.53013496
124MP0005253_abnormal_eye_physiology0.52208482
125MP0003795_abnormal_bone_structure0.51533181
126MP0000609_abnormal_liver_physiology0.49575381
127MP0005076_abnormal_cell_differentiation0.49073320
128MP0001958_emphysema0.48667225
129MP0003566_abnormal_cell_adhesion0.48166731
130MP0003656_abnormal_erythrocyte_physiolo0.48051846
131MP0000465_gastrointestinal_hemorrhage0.47696825
132MP0001191_abnormal_skin_condition0.47451607
133MP0008873_increased_physiological_sensi0.46805721
134MP0003453_abnormal_keratinocyte_physiol0.46285955
135MP0005319_abnormal_enzyme/_coenzyme0.45141270
136MP0004808_abnormal_hematopoietic_stem0.44684436
137MP0003091_abnormal_cell_migration0.44049400
138MP0009643_abnormal_urine_homeostasis0.43888517
139MP0000371_diluted_coat_color0.41333138
140MP0005174_abnormal_tail_pigmentation0.40931692
141MP0008260_abnormal_autophagy0.40768199
142MP0000767_abnormal_smooth_muscle0.39634679
143MP0003279_aneurysm0.39341031
144MP0009765_abnormal_xenobiotic_induced0.37973700

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.56890150
2Recurrent bacterial skin infections (HP:0005406)6.91550134
3Eczematoid dermatitis (HP:0000976)6.63452298
4Recurrent gram-negative bacterial infections (HP:0005420)6.12195065
5Mediastinal lymphadenopathy (HP:0100721)5.30005684
6Autoimmune thrombocytopenia (HP:0001973)4.99622715
7Agammaglobulinemia (HP:0004432)4.76258996
8Recurrent skin infections (HP:0001581)4.62877849
9Abnormality of macrophages (HP:0004311)4.59731059
10Elevated erythrocyte sedimentation rate (HP:0003565)4.58067575
11Stomatitis (HP:0010280)4.56852037
12Obstructive lung disease (HP:0006536)4.34941892
13Chronic obstructive pulmonary disease (HP:0006510)4.34941892
14Gingivitis (HP:0000230)4.34103833
15Vasculitis (HP:0002633)4.26469492
16Recurrent fungal infections (HP:0002841)4.13367075
17Systemic lupus erythematosus (HP:0002725)4.11748720
18Cellulitis (HP:0100658)4.07606751
19Meningitis (HP:0001287)4.05625758
20Increased IgM level (HP:0003496)4.01813712
21Gastrointestinal stroma tumor (HP:0100723)3.94213940
22Myositis (HP:0100614)3.88569432
23Recurrent cutaneous fungal infections (HP:0011370)3.82901584
24Chronic mucocutaneous candidiasis (HP:0002728)3.82901584
25Recurrent bronchitis (HP:0002837)3.75379980
26Interstitial pulmonary disease (HP:0006530)3.74654283
27Recurrent lower respiratory tract infections (HP:0002783)3.67682120
28Retrobulbar optic neuritis (HP:0100654)3.66086873
29Optic neuritis (HP:0100653)3.66086873
30Recurrent pneumonia (HP:0006532)3.62929504
31Recurrent sinusitis (HP:0011108)3.58846324
32Recurrent viral infections (HP:0004429)3.54722891
33Basal ganglia calcification (HP:0002135)3.54305525
34Orchitis (HP:0100796)3.41895899
35IgA deficiency (HP:0002720)3.33764709
36Vacuolated lymphocytes (HP:0001922)3.21229751
37IgG deficiency (HP:0004315)3.16628514
38Congenital stationary night blindness (HP:0007642)3.11893824
39Osteomyelitis (HP:0002754)3.08662620
40Hypergammaglobulinemia (HP:0010702)3.05537279
41Lymphopenia (HP:0001888)2.94805602
42Pustule (HP:0200039)2.93795516
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.92456558
44Abnormality of midbrain morphology (HP:0002418)2.89188237
45Molar tooth sign on MRI (HP:0002419)2.89188237
46Colitis (HP:0002583)2.87513327
47Urticaria (HP:0001025)2.86659317
48Periodontitis (HP:0000704)2.83090272
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78465274
50Pancreatic cysts (HP:0001737)2.77687169
51Emphysema (HP:0002097)2.77211313
52Pulmonary infiltrates (HP:0002113)2.75582788
53Thyroiditis (HP:0100646)2.75107414
54Inability to walk (HP:0002540)2.74850508
55Abnormality of T cell number (HP:0011839)2.73279185
56IgM deficiency (HP:0002850)2.68711236
57Glomerulonephritis (HP:0000099)2.66984964
58Sepsis (HP:0100806)2.66159704
59Combined immunodeficiency (HP:0005387)2.62476339
60Attenuation of retinal blood vessels (HP:0007843)2.61100087
61Chronic otitis media (HP:0000389)2.59590401
62Poor head control (HP:0002421)2.55982433
63Increased cerebral lipofuscin (HP:0011813)2.55760814
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.53022408
65Chronic sinusitis (HP:0011109)2.52802461
66Restrictive lung disease (HP:0002091)2.47419519
67Myocardial infarction (HP:0001658)2.45984068
68Inflammation of the large intestine (HP:0002037)2.45621167
69Thick nail (HP:0001805)2.45152058
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.45028987
71Joint hemorrhage (HP:0005261)2.44843044
72Leukocytosis (HP:0001974)2.43087240
73Petechiae (HP:0000967)2.42751778
74Hemoptysis (HP:0002105)2.40844826
75T lymphocytopenia (HP:0005403)2.40227249
76Abnormality of T cells (HP:0002843)2.37624200
77Abnormality of the prostate (HP:0008775)2.36932292
78Keratoconjunctivitis sicca (HP:0001097)2.36146559
79Nephritis (HP:0000123)2.36081319
80Arterial thrombosis (HP:0004420)2.35110877
81Abnormality of liposaccharide metabolism (HP:0010968)2.34479600
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.34479600
83Abnormality of glycolipid metabolism (HP:0010969)2.34479600
84Gingival bleeding (HP:0000225)2.33242329
85Clumsiness (HP:0002312)2.31897527
86Axonal loss (HP:0003447)2.31346501
87Hypochromic anemia (HP:0001931)2.31214027
88Concave nail (HP:0001598)2.28987347
89Gastrointestinal inflammation (HP:0004386)2.27484664
90Stomach cancer (HP:0012126)2.25106246
91Disinhibition (HP:0000734)2.24218215
92Gastrointestinal infarctions (HP:0005244)2.24127336
93Encephalitis (HP:0002383)2.22490985
94Chronic diarrhea (HP:0002028)2.22386370
95Tubular atrophy (HP:0000092)2.22112958
96Purpura (HP:0000979)2.21638617
97Abnormality of T cell physiology (HP:0011840)2.21503489
98True hermaphroditism (HP:0010459)2.21213118
99Absent/shortened dynein arms (HP:0200106)2.18833250
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.18833250
101Arthralgia (HP:0002829)2.18134676
102Cheilitis (HP:0100825)2.16240650
103Severe combined immunodeficiency (HP:0004430)2.15361099
104Autoimmune hemolytic anemia (HP:0001890)2.14446923
105Abnormality of the pleura (HP:0002103)2.13874998
106Keratoconjunctivitis (HP:0001096)2.13798885
107Mutism (HP:0002300)2.12912114
108Skin ulcer (HP:0200042)2.12403412
109Birth length less than 3rd percentile (HP:0003561)2.11949915
110Decreased central vision (HP:0007663)2.11338541
111Pancreatic fibrosis (HP:0100732)2.11100419
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10896063
113Agnosia (HP:0010524)2.09406900
114Skin rash (HP:0000988)2.08078187
115Abnormality of complement system (HP:0005339)2.07275049
116Prostate neoplasm (HP:0100787)2.07169460
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05387921
118Abnormality of alanine metabolism (HP:0010916)2.05387921
119Hyperalaninemia (HP:0003348)2.05387921
120Abnormal rod and cone electroretinograms (HP:0008323)2.03619801
121Abolished electroretinogram (ERG) (HP:0000550)2.01706020
122Nephronophthisis (HP:0000090)2.00406156
123Abnormality of eosinophils (HP:0001879)2.00331253
124Leukopenia (HP:0001882)1.97684118
125Bronchitis (HP:0012387)1.97003982
126Congenital, generalized hypertrichosis (HP:0004540)1.95638281
127Eosinophilia (HP:0001880)1.94301347
128Panhypogammaglobulinemia (HP:0003139)1.93968071
129Polydipsia (HP:0001959)1.92738922
130Abnormal drinking behavior (HP:0030082)1.92738922
131Progressive inability to walk (HP:0002505)1.92394542
132Global brain atrophy (HP:0002283)1.91778864
133Anorexia (HP:0002039)1.90530901
134Chest pain (HP:0100749)1.89396363
135Large for gestational age (HP:0001520)1.85297150
136Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85284122
137Chronic hepatic failure (HP:0100626)1.84683508
138Spontaneous hematomas (HP:0007420)1.82247676
139Hyperventilation (HP:0002883)1.81389992
140Type II lissencephaly (HP:0007260)1.79545355
141Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77029198
142Neutropenia (HP:0001875)1.73699088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK6.64237936
2PBK4.48823860
3MAP3K144.23904956
4RIPK44.15454995
5MAP4K13.63490575
6TLK13.17557204
7TYK22.97484213
8TBK12.90517915
9IRAK42.84726629
10FRK2.68043946
11IKBKB2.20547778
12SYK2.19144588
13IRAK32.16286333
14IKBKE2.13125818
15TXK2.10241889
16ZAK1.95123774
17JAK11.92097278
18MST41.91776111
19KIT1.91255483
20CSK1.88675007
21MAP3K131.85099968
22JAK31.84512456
23ZAP701.75222626
24NEK91.74122223
25WNK41.71451352
26LYN1.70565441
27ERN11.68789676
28ACVR1B1.62637265
29BMPR1B1.59751536
30BTK1.48605504
31BMPR21.36379959
32NME21.32204567
33CSF1R1.32042415
34PINK11.28791791
35CHUK1.24877410
36HCK1.24871230
37CAMKK21.23952867
38OXSR11.23273277
39PRKCQ1.18663637
40CDK191.17660176
41MAP3K101.13462431
42INSRR1.13447851
43TAOK31.08691805
44GRK71.08123855
45LCK1.04845081
46PIM21.03769928
47PRKCH1.00623682
48MAPK151.00246502
49STK100.98902443
50ADRBK10.97145293
51ABL20.96780707
52STK40.95822958
53RPS6KA40.95812296
54PIK3CA0.95410035
55CLK10.94901498
56MATK0.92257395
57GRK10.91768280
58JAK20.91602473
59RIPK10.89642549
60EPHB10.89172416
61FGR0.89008847
62MAPK130.88771514
63PTK2B0.88250251
64TEC0.85012012
65MARK30.82859483
66PRKCD0.82689984
67STK110.82054896
68TGFBR20.81783495
69CAMKK10.81324672
70PIM10.79854157
71WNK30.76477639
72GRK60.76213335
73SIK30.75891105
74EIF2AK20.74832054
75TGFBR10.74191151
76MAPK120.73294632
77MAP4K20.71217496
78PASK0.69464835
79RPS6KA50.69066804
80FGFR40.67868479
81ITK0.66062865
82MAP2K60.65696907
83WNK10.63557716
84KDR0.62636207
85ADRBK20.62594073
86FES0.62071227
87EIF2AK30.61636141
88MAP3K120.60066288
89EIF2AK10.58463287
90ABL10.58451394
91LRRK20.57482202
92BMX0.57204523
93FGFR30.57010238
94TESK10.55969150
95YES10.54356741
96IRAK10.48924403
97ERBB30.48594001
98FYN0.47046963
99MAP3K110.46114114
100MAPK70.44404361
101MAPKAPK30.41717405
102PDPK10.40938972
103PKN10.38574311
104EGFR0.37000432
105MST1R0.35701384
106CDC42BPA0.35546397
107MAP2K40.33272195
108PRKCI0.33256992
109SIK20.32387700
110IRAK20.30692092
111MAP2K20.30370511
112MAPK110.29398153
113MAP3K50.27880536
114VRK10.27556693
115MAPKAPK20.27283538
116INSR0.27134361
117ARAF0.26127636
118BCKDK0.25691837
119SGK20.25180958
120TRPM70.24204744
121STK240.24141539
122PAK30.23880469
123CAMK10.23871824
124PRKCE0.23627245
125CAMK40.23250339
126PRKCZ0.22919452
127EPHA30.22257828
128NTRK30.21652770
129IGF1R0.19736960
130PDK10.17424855
131ALK0.16274476
132MAP2K30.15842897
133PIK3CG0.15484028
134KSR20.13777933
135BCR0.12970276
136TESK20.11208025
137NUAK10.10182022
138TNK20.08474926
139RPS6KA60.07758017
140NLK0.07706607
141DAPK20.07542401
142SRC0.07131146

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.81501818
2Leishmaniasis_Homo sapiens_hsa051403.24622759
3Allograft rejection_Homo sapiens_hsa053303.21719507
4Staphylococcus aureus infection_Homo sapiens_hsa051503.17882201
5Primary immunodeficiency_Homo sapiens_hsa053403.13466156
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.10781315
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.79353685
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.76933975
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.67597955
10Type I diabetes mellitus_Homo sapiens_hsa049402.54565410
11Asthma_Homo sapiens_hsa053102.53603011
12B cell receptor signaling pathway_Homo sapiens_hsa046622.42179676
13Osteoclast differentiation_Homo sapiens_hsa043802.31988923
14Tuberculosis_Homo sapiens_hsa051522.22211092
15Pertussis_Homo sapiens_hsa051332.12958644
16Legionellosis_Homo sapiens_hsa051342.10585630
17Measles_Homo sapiens_hsa051622.07393858
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07049213
19Malaria_Homo sapiens_hsa051442.04015780
20Rheumatoid arthritis_Homo sapiens_hsa053232.02442195
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99159555
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95819535
23Autoimmune thyroid disease_Homo sapiens_hsa053201.85759319
24Salmonella infection_Homo sapiens_hsa051321.84724771
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83429648
26Antigen processing and presentation_Homo sapiens_hsa046121.78276042
27Influenza A_Homo sapiens_hsa051641.68645635
28Viral myocarditis_Homo sapiens_hsa054161.64533046
29Linoleic acid metabolism_Homo sapiens_hsa005911.61214307
30Hematopoietic cell lineage_Homo sapiens_hsa046401.59667901
31Phagosome_Homo sapiens_hsa041451.53966670
32Lysosome_Homo sapiens_hsa041421.53228919
33Herpes simplex infection_Homo sapiens_hsa051681.51752616
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50589951
35Chemokine signaling pathway_Homo sapiens_hsa040621.47295237
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44456718
37TNF signaling pathway_Homo sapiens_hsa046681.39834338
38Shigellosis_Homo sapiens_hsa051311.37942294
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36174287
40African trypanosomiasis_Homo sapiens_hsa051431.35777332
41Toxoplasmosis_Homo sapiens_hsa051451.35505224
42Apoptosis_Homo sapiens_hsa042101.31674444
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22010123
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.11483355
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03751449
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03519131
47Nitrogen metabolism_Homo sapiens_hsa009101.03226135
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00717300
49Ether lipid metabolism_Homo sapiens_hsa005650.99847642
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97817483
51Other glycan degradation_Homo sapiens_hsa005110.95661673
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95132653
53Complement and coagulation cascades_Homo sapiens_hsa046100.92223776
54Proteasome_Homo sapiens_hsa030500.87595009
55Phototransduction_Homo sapiens_hsa047440.86619518
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.85452862
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85342414
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84996669
59Hepatitis B_Homo sapiens_hsa051610.81532237
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.75586336
61T cell receptor signaling pathway_Homo sapiens_hsa046600.74124865
62Hepatitis C_Homo sapiens_hsa051600.70252158
63ABC transporters_Homo sapiens_hsa020100.69425990
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69160536
65Selenocompound metabolism_Homo sapiens_hsa004500.67484500
66Base excision repair_Homo sapiens_hsa034100.67228335
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66920007
68Arachidonic acid metabolism_Homo sapiens_hsa005900.66501579
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65701308
70Prion diseases_Homo sapiens_hsa050200.64127665
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63361499
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63075209
73Epstein-Barr virus infection_Homo sapiens_hsa051690.62292892
74Butanoate metabolism_Homo sapiens_hsa006500.61047299
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52137672
76Mismatch repair_Homo sapiens_hsa034300.51536077
77DNA replication_Homo sapiens_hsa030300.49839877
78Olfactory transduction_Homo sapiens_hsa047400.49571902
79Morphine addiction_Homo sapiens_hsa050320.49507349
80Tryptophan metabolism_Homo sapiens_hsa003800.48674367
81Platelet activation_Homo sapiens_hsa046110.45341792
82Amoebiasis_Homo sapiens_hsa051460.45295414
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.43930492
84Vitamin digestion and absorption_Homo sapiens_hsa049770.43508339
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43286567
86Collecting duct acid secretion_Homo sapiens_hsa049660.43146126
87Acute myeloid leukemia_Homo sapiens_hsa052210.42501706
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42140345
89Oxidative phosphorylation_Homo sapiens_hsa001900.41143187
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39612317
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39563083
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38908365
93Pancreatic cancer_Homo sapiens_hsa052120.37569108
94Taste transduction_Homo sapiens_hsa047420.37398482
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34648775
96Prolactin signaling pathway_Homo sapiens_hsa049170.34507210
97Homologous recombination_Homo sapiens_hsa034400.33846944
98Ovarian steroidogenesis_Homo sapiens_hsa049130.32804310
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32617782
100Ribosome_Homo sapiens_hsa030100.30348469
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.29613927
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29163406
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.28756967
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28715823
105HTLV-I infection_Homo sapiens_hsa051660.27964266
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27003033
107Nicotine addiction_Homo sapiens_hsa050330.26270352
108Viral carcinogenesis_Homo sapiens_hsa052030.26084381
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.25191315
110Regulation of autophagy_Homo sapiens_hsa041400.23871245
111MAPK signaling pathway_Homo sapiens_hsa040100.23670402
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23537733
113Fanconi anemia pathway_Homo sapiens_hsa034600.22161995
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.21768733
115Caffeine metabolism_Homo sapiens_hsa002320.21633241
116Cholinergic synapse_Homo sapiens_hsa047250.20887998
117Serotonergic synapse_Homo sapiens_hsa047260.20304635
118Chronic myeloid leukemia_Homo sapiens_hsa052200.20065697
119Glycerolipid metabolism_Homo sapiens_hsa005610.20032863
120Basal transcription factors_Homo sapiens_hsa030220.19608168
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19135634
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17705407
123Peroxisome_Homo sapiens_hsa041460.17513559
124Calcium signaling pathway_Homo sapiens_hsa040200.16936945
125Endocytosis_Homo sapiens_hsa041440.15192579
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14671866
127HIF-1 signaling pathway_Homo sapiens_hsa040660.13861967
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.13807909
129Parkinsons disease_Homo sapiens_hsa050120.13693216
130Pentose phosphate pathway_Homo sapiens_hsa000300.11713511
131Systemic lupus erythematosus_Homo sapiens_hsa053220.10364645
132Nucleotide excision repair_Homo sapiens_hsa034200.09546173
133VEGF signaling pathway_Homo sapiens_hsa043700.08237408
134p53 signaling pathway_Homo sapiens_hsa041150.05348578
135Steroid biosynthesis_Homo sapiens_hsa001000.03983149
136Small cell lung cancer_Homo sapiens_hsa052220.03364055
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02763042
138Dorso-ventral axis formation_Homo sapiens_hsa043200.02575770
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.01625040
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0176136

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