SCIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hypersensitivity (GO:0002883)7.69106679
2thrombin receptor signaling pathway (GO:0070493)7.31831261
3positive regulation of mast cell activation involved in immune response (GO:0033008)6.92367783
4positive regulation of mast cell degranulation (GO:0043306)6.92367783
5tyrosine phosphorylation of STAT protein (GO:0007260)6.88253097
6production of molecular mediator involved in inflammatory response (GO:0002532)6.73913365
7leukotriene biosynthetic process (GO:0019370)5.89764311
8positive regulation of myeloid leukocyte mediated immunity (GO:0002888)5.78491678
9positive regulation of mast cell activation (GO:0033005)5.65839594
10regulation of acute inflammatory response to antigenic stimulus (GO:0002864)5.22409434
11positive regulation of leukocyte degranulation (GO:0043302)5.11249664
12leukotriene metabolic process (GO:0006691)4.73673001
13positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.71781255
14regulation of guanylate cyclase activity (GO:0031282)4.68578065
15regulation of mast cell degranulation (GO:0043304)4.53970524
16intestinal absorption (GO:0050892)4.45202534
17peptide hormone processing (GO:0016486)4.39901813
18regulation of mast cell activation involved in immune response (GO:0033006)4.30624543
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.29538374
20positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.18787739
21definitive hemopoiesis (GO:0060216)4.03985334
22L-fucose catabolic process (GO:0042355)3.97769852
23fucose catabolic process (GO:0019317)3.97769852
24L-fucose metabolic process (GO:0042354)3.97769852
25desmosome organization (GO:0002934)3.94602839
26epoxygenase P450 pathway (GO:0019373)3.92930845
27regulation of myeloid leukocyte mediated immunity (GO:0002886)3.86163026
28regulation of mast cell activation (GO:0033003)3.85089256
29positive regulation of guanylate cyclase activity (GO:0031284)3.81582522
30regulation of chemokine secretion (GO:0090196)3.78934265
31flavonoid metabolic process (GO:0009812)3.76286892
32lipoxygenase pathway (GO:0019372)3.73209084
33histamine secretion (GO:0001821)3.72684817
34sulfation (GO:0051923)3.72331799
35positive regulation of regulated secretory pathway (GO:1903307)3.71772384
36indolalkylamine metabolic process (GO:0006586)3.68738166
37regulation of triglyceride catabolic process (GO:0010896)3.68439593
38positive regulation of chemokine secretion (GO:0090197)3.67216326
39regulation of leukocyte degranulation (GO:0043300)3.61580006
40transepithelial transport (GO:0070633)3.60123145
41DNA deamination (GO:0045006)3.60088091
42drug catabolic process (GO:0042737)3.58913879
43intestinal cholesterol absorption (GO:0030299)3.58641028
44histamine transport (GO:0051608)3.55507737
45positive regulation of interleukin-8 secretion (GO:2000484)3.55102584
46behavioral response to nicotine (GO:0035095)3.52297366
47water-soluble vitamin biosynthetic process (GO:0042364)3.47842142
48phospholipid scrambling (GO:0017121)3.45756511
49indole-containing compound catabolic process (GO:0042436)3.43822642
50indolalkylamine catabolic process (GO:0046218)3.43822642
51tryptophan catabolic process (GO:0006569)3.43822642
52vitamin biosynthetic process (GO:0009110)3.43098521
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42658566
54fat-soluble vitamin biosynthetic process (GO:0042362)3.38354901
55interferon-gamma production (GO:0032609)3.36636039
56megakaryocyte development (GO:0035855)3.36545007
57drug metabolic process (GO:0017144)3.36377825
58exogenous drug catabolic process (GO:0042738)3.35669510
59mast cell activation (GO:0045576)3.35611813
60positive regulation of fatty acid transport (GO:2000193)3.32827742
61lipoprotein transport (GO:0042953)3.32490284
62positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.32343140
63UDP-N-acetylglucosamine metabolic process (GO:0006047)3.31520332
64axoneme assembly (GO:0035082)3.30347054
65cilium or flagellum-dependent cell motility (GO:0001539)3.25504548
66cytidine metabolic process (GO:0046087)3.22799502
67cytidine catabolic process (GO:0006216)3.22799502
68cytidine deamination (GO:0009972)3.22799502
69maintenance of gastrointestinal epithelium (GO:0030277)3.20494648
70regulation of interleukin-8 secretion (GO:2000482)3.19682361
71mast cell degranulation (GO:0043303)3.17684339
72mast cell activation involved in immune response (GO:0002279)3.17684339
73regulation of inflammatory response to antigenic stimulus (GO:0002861)3.16820300
74kidney morphogenesis (GO:0060993)3.16771775
75dendritic cell chemotaxis (GO:0002407)3.12521878
76positive regulation of icosanoid secretion (GO:0032305)3.12037021
77germ cell migration (GO:0008354)3.09435978
78digestion (GO:0007586)3.08895405
79cilium movement (GO:0003341)3.08512791
80dendritic cell migration (GO:0036336)3.07392809
81platelet dense granule organization (GO:0060155)3.06500409
82epithelial cilium movement (GO:0003351)3.06141998
83regulation of cGMP biosynthetic process (GO:0030826)3.04296281
84vitamin A metabolic process (GO:0006776)3.02582227
85positive regulation of macrophage differentiation (GO:0045651)2.97237698
86regulation of regulated secretory pathway (GO:1903305)2.95064209
87icosanoid biosynthetic process (GO:0046456)2.93849649
88fatty acid derivative biosynthetic process (GO:1901570)2.93849649
89glycerol metabolic process (GO:0006071)2.93685242
90cellular ketone body metabolic process (GO:0046950)2.92706374
91bile acid and bile salt transport (GO:0015721)2.92640861
92regulation of systemic arterial blood pressure by hormone (GO:0001990)2.92024168
93regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.92024168
94endocrine process (GO:0050886)2.92024168
95sulfur compound transport (GO:0072348)2.91289560
96regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.89715621
97sulfate transmembrane transport (GO:1902358)2.88936777
98tryptophan metabolic process (GO:0006568)2.88914662
99kynurenine metabolic process (GO:0070189)2.86911113
100negative regulation of mast cell activation (GO:0033004)2.85994229
101vitamin transmembrane transport (GO:0035461)2.85890987
102indole-containing compound metabolic process (GO:0042430)2.83831170
103regulation of T cell receptor signaling pathway (GO:0050856)2.83409405
104cobalamin metabolic process (GO:0009235)2.83336113
105positive regulation of calcium-mediated signaling (GO:0050850)2.82889018
106membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81660917
107primary amino compound metabolic process (GO:1901160)2.81492578
108hepatocyte apoptotic process (GO:0097284)2.80794562
109alkaloid metabolic process (GO:0009820)2.80264781
110quinone biosynthetic process (GO:1901663)2.79867260
111glucuronate metabolic process (GO:0019585)2.79822560
112uronic acid metabolic process (GO:0006063)2.79822560
113ketone body metabolic process (GO:1902224)2.77646408
114positive regulation of acute inflammatory response (GO:0002675)2.77248884
115pyrimidine ribonucleoside catabolic process (GO:0046133)2.77048329
116arginine metabolic process (GO:0006525)2.76761706
117bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75267011
118cellular glucuronidation (GO:0052695)2.73474837
119phosphatidylinositol acyl-chain remodeling (GO:0036149)2.71964334
120hemidesmosome assembly (GO:0031581)2.71271167
121axonemal dynein complex assembly (GO:0070286)2.71177287
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70590644
123regulation of cellular extravasation (GO:0002691)2.70246925
124proline transport (GO:0015824)2.69617779
125positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.67636391
126regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.67636391
127fat-soluble vitamin metabolic process (GO:0006775)2.67383329
128auditory receptor cell differentiation (GO:0042491)2.67043959
129phosphatidylserine acyl-chain remodeling (GO:0036150)2.66285245
130toxin transport (GO:1901998)2.63820105
131notochord development (GO:0030903)2.63525321
132regulation of cGMP metabolic process (GO:0030823)2.61954884
133actin filament depolymerization (GO:0030042)2.61418517
134cellular response to ATP (GO:0071318)2.60146181
135actin filament polymerization (GO:0030041)2.59110150
136photoreceptor cell maintenance (GO:0045494)2.58685598
137parturition (GO:0007567)2.57912839
138positive regulation of respiratory burst (GO:0060267)2.57874290
139vitamin transport (GO:0051180)2.56683353
140serotonin metabolic process (GO:0042428)2.56227455
141negative regulation of bone resorption (GO:0045779)2.56130728
142urate metabolic process (GO:0046415)2.56093378
143positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54773650
144positive regulation of fatty acid oxidation (GO:0046321)2.54705771
145polyol transport (GO:0015791)2.54595030
146phenol-containing compound catabolic process (GO:0019336)2.54410885
147negative regulation of keratinocyte proliferation (GO:0010839)2.53942550
148sulfate transport (GO:0008272)2.53667431
149excretion (GO:0007588)2.53171870
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52695556
151antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52695556
152regulation of systemic arterial blood pressure (GO:0003073)2.51925135
153regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.51630972
154peptide catabolic process (GO:0043171)2.51580515
155glutathione derivative metabolic process (GO:1901685)2.51550300
156glutathione derivative biosynthetic process (GO:1901687)2.51550300
157membrane repolarization during action potential (GO:0086011)2.51516336
158thyroid hormone metabolic process (GO:0042403)2.50953579
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50477140
160regulation of interleukin-1 beta secretion (GO:0050706)2.50448034
161positive regulation of glycoprotein biosynthetic process (GO:0010560)2.49837621
162cytokine metabolic process (GO:0042107)2.49451169
163digestive system process (GO:0022600)2.49253797
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.48992693
165antigen processing and presentation of endogenous antigen (GO:0019883)2.48662234
166adenosine metabolic process (GO:0046085)2.48166454
167benzene-containing compound metabolic process (GO:0042537)2.47888438
168negative regulation of phagocytosis (GO:0050765)2.47380409
169endocrine pancreas development (GO:0031018)2.47204755
170regulation of RIG-I signaling pathway (GO:0039535)2.45847430
171cytokine biosynthetic process (GO:0042089)2.45566974
172alditol metabolic process (GO:0019400)2.45267249
173positive regulation of interleukin-1 beta secretion (GO:0050718)2.44397215
174cellular response to exogenous dsRNA (GO:0071360)2.44367451
175purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.43823514
1763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.43823514
177positive regulation of oligodendrocyte differentiation (GO:0048714)2.43516313
178L-ascorbic acid metabolic process (GO:0019852)2.42923042
179production of molecular mediator of immune response (GO:0002440)2.42111025
180positive regulation of cGMP biosynthetic process (GO:0030828)2.42005573
181intestinal epithelial cell development (GO:0060576)2.41048201
182oligosaccharide catabolic process (GO:0009313)2.40544836
183sphingomyelin metabolic process (GO:0006684)2.39967398
184positive regulation of extracellular matrix organization (GO:1903055)2.39911552
185regulation of protein glycosylation (GO:0060049)2.39815856
186branching involved in labyrinthine layer morphogenesis (GO:0060670)2.38431544
187purinergic nucleotide receptor signaling pathway (GO:0035590)2.38274389
188regulation of macrophage differentiation (GO:0045649)2.38196389
189secretory granule organization (GO:0033363)2.37168763
190cytokine production involved in immune response (GO:0002367)2.36838511
191adhesion of symbiont to host cell (GO:0044650)2.36297030
192angiotensin maturation (GO:0002003)11.9970655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.26543295
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.80597399
3SCL_19346495_ChIP-Seq_HPC-7_Human3.49430577
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11067490
5VDR_22108803_ChIP-Seq_LS180_Human3.10777455
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97433032
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66951773
8ZNF274_21170338_ChIP-Seq_K562_Hela2.63047947
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.61991668
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.49616513
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47520725
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.37562701
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34369916
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.12983152
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10945455
16GATA1_22025678_ChIP-Seq_K562_Human2.07439863
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03154162
18GBX2_23144817_ChIP-Seq_PC3_Human2.02372067
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94908096
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.94455177
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87717372
22AR_21572438_ChIP-Seq_LNCaP_Human1.85330271
23ER_23166858_ChIP-Seq_MCF-7_Human1.81689887
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81244600
25SOX2_20726797_ChIP-Seq_SW620_Human1.81195470
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.80078291
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78319842
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77918410
29EZH2_22144423_ChIP-Seq_EOC_Human1.76324299
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75922961
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75922211
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73770750
33EGR1_19032775_ChIP-ChIP_M12_Human1.72476153
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71030294
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70786518
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70383294
37BCAT_22108803_ChIP-Seq_LS180_Human1.69028433
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68554041
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68268757
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.65396066
41IGF1R_20145208_ChIP-Seq_DFB_Human1.65050287
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63647256
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63313886
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.61159436
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61142634
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.59522569
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57919844
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56113967
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56092432
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55672442
51GATA4_25053715_ChIP-Seq_YYC3_Human1.53989159
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53247534
53RUNX_20019798_ChIP-Seq_JUKART_Human1.51295453
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49932792
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48316821
56* CDX2_22108803_ChIP-Seq_LS180_Human1.48292689
57FUS_26573619_Chip-Seq_HEK293_Human1.48055652
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47047754
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.47047754
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.46232701
61TP53_18474530_ChIP-ChIP_U2OS_Human1.44468175
62TCF4_22108803_ChIP-Seq_LS180_Human1.44165236
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42664326
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41473199
65* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40606732
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.40240025
67* STAT3_23295773_ChIP-Seq_U87_Human1.39259468
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.38820641
69CBP_20019798_ChIP-Seq_JUKART_Human1.37235355
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37235355
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37027067
72* SMAD4_21799915_ChIP-Seq_A2780_Human1.36172444
73EWS_26573619_Chip-Seq_HEK293_Human1.35952734
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.33929806
75TCF4_23295773_ChIP-Seq_U87_Human1.33600046
76AR_25329375_ChIP-Seq_VCAP_Human1.32673584
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32310615
78* AR_20517297_ChIP-Seq_VCAP_Human1.31149544
79VDR_24787735_ChIP-Seq_THP-1_Human1.30789839
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.30137146
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29318228
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29059599
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27513290
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26964428
85NANOG_19829295_ChIP-Seq_ESCs_Human1.26906669
86SOX2_19829295_ChIP-Seq_ESCs_Human1.26906669
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26049021
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26049021
89CJUN_26792858_Chip-Seq_BT549_Human1.25957935
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25611019
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.25320180
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24696607
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23315445
94NCOR_22424771_ChIP-Seq_293T_Human1.23192221
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21062384
96GATA6_25053715_ChIP-Seq_YYC3_Human1.21010545
97GATA2_19941826_ChIP-Seq_K562_Human1.20622225
98AHR_22903824_ChIP-Seq_MCF-7_Human1.20568144
99DROSHA_22980978_ChIP-Seq_HELA_Human1.20544406
100IRF1_19129219_ChIP-ChIP_H3396_Human1.18773404
101* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18686780
102MYB_26560356_Chip-Seq_TH2_Human1.18172748
103* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18146697
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17880477
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17616092
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.17580163
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.17526654
108TP53_22573176_ChIP-Seq_HFKS_Human1.17333904
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16466227
110TP53_16413492_ChIP-PET_HCT116_Human1.15110077
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.13673376
112CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13348823
113AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11772055
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11420705
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11401060
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11400772
117GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11372898
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09640036
119VDR_24763502_ChIP-Seq_THP-1_Human1.09440903
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09422566
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08888207
122SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08733222
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.08701393
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08492512
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.08022140
126FLI1_27457419_Chip-Seq_LIVER_Mouse1.07669480
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07126400
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06984349
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06354636
130TAF15_26573619_Chip-Seq_HEK293_Human1.06088263
131* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05670374
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05117236
133RUNX2_22187159_ChIP-Seq_PCA_Human1.04748505
134BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04043516
135ETV1_20927104_ChIP-Seq_GIST48_Human1.03754882
136HOXB7_26014856_ChIP-Seq_BT474_Human1.02554766
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02532541
138NANOG_20526341_ChIP-Seq_ESCs_Human1.02317684
139CBX2_27304074_Chip-Seq_ESCs_Mouse1.01988151
140* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01062540
141GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00779772
142SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00676147
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00276156
144* MYC_19829295_ChIP-Seq_ESCs_Human0.99753298
145REST_21632747_ChIP-Seq_MESCs_Mouse0.99106015
146FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96485392
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96224857
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95533915
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.94910235
150SPI1_23547873_ChIP-Seq_NB4_Human0.94140205
151NFE2_27457419_Chip-Seq_LIVER_Mouse0.93650719
152PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93285618
153EGR1_19374776_ChIP-ChIP_THP-1_Human0.92309132
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.91717759
155KLF5_25053715_ChIP-Seq_YYC3_Human0.91033537
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.90382114
157P300_19829295_ChIP-Seq_ESCs_Human0.90012761
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89433951
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89433951
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88454634
161RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87557369
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86963072
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86864231
164P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85085393
165TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84463938
166PU_27001747_Chip-Seq_BMDM_Mouse0.84338554
167TP63_23658742_ChIP-Seq_EP156T_Human0.83687055
168TAL1_26923725_Chip-Seq_HPCs_Mouse0.82913765
169MYB_26560356_Chip-Seq_TH1_Human0.82180372
170NANOG_18555785_Chip-Seq_ESCs_Mouse0.82147677
171P53_22387025_ChIP-Seq_ESCs_Mouse0.80711255
172RXR_22108803_ChIP-Seq_LS180_Human0.79969674
173MAF_26560356_Chip-Seq_TH1_Human0.77616315
174POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76577157
175BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76409821
176SUZ12_18555785_Chip-Seq_ESCs_Mouse0.75582076
177STAT3_18555785_Chip-Seq_ESCs_Mouse0.74809488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.38543642
2MP0002877_abnormal_melanocyte_morpholog3.27473062
3MP0000465_gastrointestinal_hemorrhage3.26436990
4MP0005085_abnormal_gallbladder_physiolo3.03488592
5MP0004019_abnormal_vitamin_homeostasis3.01074667
6MP0002254_reproductive_system_inflammat2.91048718
7MP0003866_abnormal_defecation2.69850848
8MP0010234_abnormal_vibrissa_follicle2.68985547
9MP0002148_abnormal_hypersensitivity_rea2.64054065
10MP0005360_urolithiasis2.54411323
11MP0010155_abnormal_intestine_physiology2.54208090
12MP0003183_abnormal_peptide_metabolism2.54131526
13MP0001873_stomach_inflammation2.53676432
14MP0000383_abnormal_hair_follicle2.46722446
15MP0003436_decreased_susceptibility_to2.32187208
16MP0001188_hyperpigmentation2.31609420
17MP0005365_abnormal_bile_salt2.26093390
18MP0005646_abnormal_pituitary_gland2.24984043
19MP0005464_abnormal_platelet_physiology2.19841077
20MP0004147_increased_porphyrin_level2.17391278
21MP0001663_abnormal_digestive_system2.14801813
22MP0002139_abnormal_hepatobiliary_system2.11792478
23MP0010678_abnormal_skin_adnexa2.10486679
24MP0004264_abnormal_extraembryonic_tissu2.07935600
25MP0005174_abnormal_tail_pigmentation2.05685736
26MP0005671_abnormal_response_to2.01882844
27MP0008872_abnormal_physiological_respon2.00395763
28MP0001485_abnormal_pinna_reflex1.98142419
29MP0005332_abnormal_amino_acid1.93320531
30MP0008875_abnormal_xenobiotic_pharmacok1.92949309
31MP0000490_abnormal_crypts_of1.92812217
32MP0002933_joint_inflammation1.92121653
33MP0005310_abnormal_salivary_gland1.87640997
34MP0001666_abnormal_nutrient_absorption1.84676409
35MP0005551_abnormal_eye_electrophysiolog1.81848026
36MP0001790_abnormal_immune_system1.81447830
37MP0005387_immune_system_phenotype1.81447830
38MP0001835_abnormal_antigen_presentation1.81367122
39MP0001501_abnormal_sleep_pattern1.80760569
40MP0000372_irregular_coat_pigmentation1.80468478
41MP0010329_abnormal_lipoprotein_level1.78723264
42MP0005381_digestive/alimentary_phenotyp1.77585002
43MP0003300_gastrointestinal_ulcer1.77303523
44MP0009785_altered_susceptibility_to1.75651452
45MP0002419_abnormal_innate_immunity1.73113615
46MP0005670_abnormal_white_adipose1.69777066
47MP0002102_abnormal_ear_morphology1.69166119
48MP0001533_abnormal_skeleton_physiology1.68196564
49MP0002163_abnormal_gland_morphology1.67835499
50MP0000462_abnormal_digestive_system1.67566777
51MP0005367_renal/urinary_system_phenotyp1.65805691
52MP0000516_abnormal_urinary_system1.65805691
53MP0009643_abnormal_urine_homeostasis1.63674773
54MP0001819_abnormal_immune_cell1.61301621
55MP0005025_abnormal_response_to1.60474923
56MP0003283_abnormal_digestive_organ1.59808381
57MP0005636_abnormal_mineral_homeostasis1.59358933
58MP0004134_abnormal_chest_morphology1.58141127
59MP0002420_abnormal_adaptive_immunity1.57554854
60MP0004947_skin_inflammation1.57381295
61MP0001800_abnormal_humoral_immune1.57291640
62MP0005000_abnormal_immune_tolerance1.57233254
63MP0002452_abnormal_antigen_presenting1.56966304
64MP0003879_abnormal_hair_cell1.56446014
65MP0004885_abnormal_endolymph1.52771611
66MP0002837_dystrophic_cardiac_calcinosis1.50382308
67MP0003566_abnormal_cell_adhesion1.50117611
68MP0000538_abnormal_urinary_bladder1.49948760
69MP0003941_abnormal_skin_development1.48884103
70MP0003718_maternal_effect1.48037613
71MP0003646_muscle_fatigue1.43948066
72MP0000343_altered_response_to1.43355884
73MP0002723_abnormal_immune_serum1.42010377
74MP0005645_abnormal_hypothalamus_physiol1.41940686
75MP0009379_abnormal_foot_pigmentation1.41360197
76MP0001756_abnormal_urination1.41158585
77MP0006054_spinal_hemorrhage1.40840371
78MP0003638_abnormal_response/metabolism_1.40177209
79MP0000230_abnormal_systemic_arterial1.38847437
80MP0009333_abnormal_splenocyte_physiolog1.37351145
81MP0002277_abnormal_respiratory_mucosa1.35468871
82MP0009764_decreased_sensitivity_to1.34810257
83MP0002098_abnormal_vibrissa_morphology1.33658954
84MP0003252_abnormal_bile_duct1.33644049
85MP0001845_abnormal_inflammatory_respons1.32847491
86MP0001764_abnormal_homeostasis1.31080675
87MP0000427_abnormal_hair_cycle1.30567481
88MP0002009_preneoplasia1.28443310
89MP0002398_abnormal_bone_marrow1.24771488
90MP0002638_abnormal_pupillary_reflex1.23747047
91MP0004808_abnormal_hematopoietic_stem1.23314211
92MP0002909_abnormal_adrenal_gland1.22154407
93MP0002396_abnormal_hematopoietic_system1.21657065
94MP0001270_distended_abdomen1.21137795
95MP0006082_CNS_inflammation1.19752974
96MP0009765_abnormal_xenobiotic_induced1.19642823
97MP0002796_impaired_skin_barrier1.18413414
98MP0010352_gastrointestinal_tract_polyps1.18343166
99MP0001216_abnormal_epidermal_layer1.17592799
100MP0002405_respiratory_system_inflammati1.16494367
101MP0005390_skeleton_phenotype1.14923224
102MP0006072_abnormal_retinal_apoptosis1.14788053
103MP0008877_abnormal_DNA_methylation1.13595666
104MP0009840_abnormal_foam_cell1.13332503
105MP0003787_abnormal_imprinting1.12912444
106MP0000015_abnormal_ear_pigmentation1.12847886
107MP0002138_abnormal_hepatobiliary_system1.11908360
108MP0003724_increased_susceptibility_to1.11607343
109MP0001346_abnormal_lacrimal_gland1.11070026
110MP0003795_abnormal_bone_structure1.11007970
111MP0002160_abnormal_reproductive_system1.10963993
112MP0005448_abnormal_energy_balance1.09679628
113MP0000477_abnormal_intestine_morphology1.08557097
114MP0001765_abnormal_ion_homeostasis1.07975285
115MP0005389_reproductive_system_phenotype1.07861680
116MP0000569_abnormal_digit_pigmentation1.07108612
117MP0001968_abnormal_touch/_nociception1.06103752
118MP0005253_abnormal_eye_physiology1.03595755
119MP0000716_abnormal_immune_system1.03197936
120MP0004381_abnormal_hair_follicle1.02856412
121MP0002998_abnormal_bone_remodeling1.01974727
122MP0002938_white_spotting1.01871956
123MP0009745_abnormal_behavioral_response0.99485588
124MP0002722_abnormal_immune_system0.99030486
125MP0005075_abnormal_melanosome_morpholog0.98995559
126MP0002272_abnormal_nervous_system0.97805594
127MP0001853_heart_inflammation0.96572495
128MP0003136_yellow_coat_color0.96473804
129MP0005409_darkened_coat_color0.96056444
130MP0001664_abnormal_digestion0.94893306
131MP0010386_abnormal_urinary_bladder0.94601532
132MP0000631_abnormal_neuroendocrine_gland0.94600252
133MP0000163_abnormal_cartilage_morphology0.94347304
134MP0005379_endocrine/exocrine_gland_phen0.93405024
135MP0002118_abnormal_lipid_homeostasis0.91815728
136MP0000467_abnormal_esophagus_morphology0.91582700
137MP0000377_abnormal_hair_follicle0.91185863
138MP0009697_abnormal_copulation0.90931577
139MP0002095_abnormal_skin_pigmentation0.90871172
140MP0002429_abnormal_blood_cell0.90537515
141MP0002113_abnormal_skeleton_development0.90475474
142MP0005171_absent_coat_pigmentation0.90082185
143MP0008469_abnormal_protein_level0.88785423
144MP0002876_abnormal_thyroid_physiology0.88387947
145MP0001986_abnormal_taste_sensitivity0.88231792
146MP0001970_abnormal_pain_threshold0.88220375
147MP0004043_abnormal_pH_regulation0.87998751
148MP0003763_abnormal_thymus_physiology0.87379548
149MP0002282_abnormal_trachea_morphology0.87132726
150MP0002733_abnormal_thermal_nociception0.86916538
151MP0002136_abnormal_kidney_physiology0.86130339
152MP0005166_decreased_susceptibility_to0.86115511
153MP0003011_delayed_dark_adaptation0.86111957
154MP0003453_abnormal_keratinocyte_physiol0.86020777
155MP0002693_abnormal_pancreas_physiology0.85114431
156MP0005377_hearing/vestibular/ear_phenot0.84835880
157MP0003878_abnormal_ear_physiology0.84835880
158MP0001919_abnormal_reproductive_system0.81857388
159MP0009780_abnormal_chondrocyte_physiolo0.81204178
160MP0005408_hypopigmentation0.80906991
161MP0002736_abnormal_nociception_after0.77917045
162MP0008775_abnormal_heart_ventricle0.77046678
163MP0002734_abnormal_mechanical_nocicepti0.76932358
164MP0009046_muscle_twitch0.76071326
165MP0004142_abnormal_muscle_tone0.75582641
166MP0003953_abnormal_hormone_level0.75407216
167MP0002557_abnormal_social/conspecific_i0.71708163
168MP0003806_abnormal_nucleotide_metabolis0.70648136
169MP0005535_abnormal_body_temperature0.70425486
170MP0002229_neurodegeneration0.70418403

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.32340714
2Petechiae (HP:0000967)6.22633615
3Irregular epiphyses (HP:0010582)5.77200613
4Cupped ribs (HP:0000887)5.22607621
5Abnormal tarsal ossification (HP:0008369)4.82985513
6Flat acetabular roof (HP:0003180)4.79636246
7Abnormal platelet volume (HP:0011876)4.29477158
8Increased mean platelet volume (HP:0011877)4.25752185
9Decreased circulating renin level (HP:0003351)4.16222362
10Abnormal platelet function (HP:0011869)3.96428223
11Impaired platelet aggregation (HP:0003540)3.96428223
12Vitreoretinal degeneration (HP:0000655)3.85351980
13Flat capital femoral epiphysis (HP:0003370)3.78139062
14Pancreatic cysts (HP:0001737)3.73504225
15Abnormal foot bone ossification (HP:0010675)3.72775065
16Prolonged bleeding time (HP:0003010)3.71720965
17Genu varum (HP:0002970)3.71587268
18Abnormality of vitamin B metabolism (HP:0004340)3.65757228
19Abnormality of the vitamin B12 metabolism (HP:0004341)3.61721279
20Purpura (HP:0000979)3.55033408
21Small epiphyses (HP:0010585)3.50268735
22Abnormality of renin-angiotensin system (HP:0000847)3.48342543
23Delayed epiphyseal ossification (HP:0002663)3.47816554
24Menorrhagia (HP:0000132)3.39642148
25Pancreatic fibrosis (HP:0100732)3.27972067
26Congenital stationary night blindness (HP:0007642)3.24612364
27Abnormality of carpal bone ossification (HP:0006257)3.20369368
28Gingival bleeding (HP:0000225)3.19484473
29True hermaphroditism (HP:0010459)3.10307539
30Right ventricular cardiomyopathy (HP:0011663)3.05758866
31Abnormality of midbrain morphology (HP:0002418)3.05425732
32Molar tooth sign on MRI (HP:0002419)3.05425732
33Hypoplastic ischia (HP:0003175)3.03163469
34Metaphyseal irregularity (HP:0003025)3.01505719
35White forelock (HP:0002211)3.00230421
36Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.97512800
37Abnormality of femoral epiphyses (HP:0006499)2.97512800
38Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.96002994
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.95262648
40Absent/shortened dynein arms (HP:0200106)2.95262648
41Confusion (HP:0001289)2.92665221
42Metabolic alkalosis (HP:0200114)2.91113493
43Abnormality of the renal cortex (HP:0011035)2.89677957
44Alkalosis (HP:0001948)2.89463973
45Abnormal drinking behavior (HP:0030082)2.89180595
46Polydipsia (HP:0001959)2.89180595
47Abolished electroretinogram (ERG) (HP:0000550)2.82314115
48Short femoral neck (HP:0100864)2.82097690
49Metaphyseal dysplasia (HP:0100255)2.81282837
50Flattened epiphyses (HP:0003071)2.80185146
51Abnormality of the epiphysis of the femoral head (HP:0010574)2.79523008
52Chronic diarrhea (HP:0002028)2.77647013
53Abnormality of proline metabolism (HP:0010907)2.76935555
54Hydroxyprolinuria (HP:0003080)2.76935555
55Nephronophthisis (HP:0000090)2.76567396
56Abnormal respiratory epithelium morphology (HP:0012253)2.75781123
57Abnormal respiratory motile cilium morphology (HP:0005938)2.75781123
58Patchy hypopigmentation of hair (HP:0011365)2.75548226
59Neonatal short-limb short stature (HP:0008921)2.72962379
60Hyperglycinuria (HP:0003108)2.72411409
61Abnormality of urine glucose concentration (HP:0011016)2.71465981
62Glycosuria (HP:0003076)2.71465981
63Abnormality of the vertebral endplates (HP:0005106)2.69852616
64Abnormality of vitamin metabolism (HP:0100508)2.68399816
65Methylmalonic aciduria (HP:0012120)2.68171516
66Abnormal vertebral ossification (HP:0100569)2.67825469
67Abnormal ciliary motility (HP:0012262)2.67457431
68Abnormality of the femoral head (HP:0003368)2.65231346
69Cervical subluxation (HP:0003308)2.59588009
70Increased IgE level (HP:0003212)2.58989216
71Abnormality of the ischium (HP:0003174)2.57993375
72Hyperactive renin-angiotensin system (HP:0000841)2.57628100
73Abnormality of the renal medulla (HP:0100957)2.54643404
74Pigmentary retinal degeneration (HP:0001146)2.53221099
75Abnormality of glycine metabolism (HP:0010895)2.52749175
76Abnormality of serine family amino acid metabolism (HP:0010894)2.52749175
77Tubular atrophy (HP:0000092)2.51488870
78Hyperventilation (HP:0002883)2.50544710
79Abnormal hand bone ossification (HP:0010660)2.48379123
80Enlarged epiphyses (HP:0010580)2.48251558
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.46464218
82Abnormality of magnesium homeostasis (HP:0004921)2.46286706
83Abnormal respiratory motile cilium physiology (HP:0012261)2.43731448
84Abnormal urine output (HP:0012590)2.43080344
85Cystic liver disease (HP:0006706)2.42981665
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.40807442
87Aplasia/hypoplasia of the femur (HP:0005613)2.40604904
88Polyuria (HP:0000103)2.39283048
89Abnormality of renal excretion (HP:0011036)2.39127711
90Hypomagnesemia (HP:0002917)2.38877586
91Recurrent fungal infections (HP:0002841)2.36631147
92Disproportionate short-trunk short stature (HP:0003521)2.35486877
93Abnormality of incisor morphology (HP:0011063)2.34108220
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.32241239
95Chorioretinal atrophy (HP:0000533)2.31691379
96Malnutrition (HP:0004395)2.30686628
97Abnormal ossification of hand bones (HP:0005921)2.30099113
98Abnormality of chloride homeostasis (HP:0011422)2.29449850
99Stillbirth (HP:0003826)2.25870586
100Metaphyseal cupping (HP:0003021)2.25632257
101Ovoid vertebral bodies (HP:0003300)2.24967044
102Ketoacidosis (HP:0001993)2.24614246
103Proximal tubulopathy (HP:0000114)2.24074816
104Attenuation of retinal blood vessels (HP:0007843)2.22654816
105Potter facies (HP:0002009)2.21831677
106Facial shape deformation (HP:0011334)2.21831677
107Autoimmune hemolytic anemia (HP:0001890)2.21657673
108Ketosis (HP:0001946)2.20451875
109Hypokalemia (HP:0002900)2.20214987
110Methylmalonic acidemia (HP:0002912)2.19857457
111Thoracolumbar scoliosis (HP:0002944)2.19775257
112Spinal cord compression (HP:0002176)2.19720165
113Renal cortical cysts (HP:0000803)2.18660264
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.18431269
115Absent epiphyses (HP:0010577)2.18431269
116Increased circulating renin level (HP:0000848)2.17048325
117Hypothermia (HP:0002045)2.15714955
118Furrowed tongue (HP:0000221)2.14657817
119Rhinitis (HP:0012384)2.14227734
120Pendular nystagmus (HP:0012043)2.12789443
121Gaze-evoked nystagmus (HP:0000640)2.12679743
122Chronic hepatic failure (HP:0100626)2.09351278
123Barrel-shaped chest (HP:0001552)2.09004936
124Prostate neoplasm (HP:0100787)2.08888923
125Abdominal distention (HP:0003270)2.08295173
126Hyperaldosteronism (HP:0000859)2.06305627
127Abnormal rod and cone electroretinograms (HP:0008323)2.06139068
128Irregular vertebral endplates (HP:0003301)2.05777550
129Autoimmune thrombocytopenia (HP:0001973)2.05361759
130Clumsiness (HP:0002312)2.05204197
131Recurrent viral infections (HP:0004429)2.04918369
132Retrobulbar optic neuritis (HP:0100654)2.04746688
133Optic neuritis (HP:0100653)2.04746688
134Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03635785
135Abnormal albumin level (HP:0012116)2.02053650
136Hypoalbuminemia (HP:0003073)2.02053650
137Congenital, generalized hypertrichosis (HP:0004540)2.01281221
138Beaking of vertebral bodies (HP:0004568)2.00520936
139Abnormality of the lumbar spine (HP:0100712)2.00071606
140Coxa vara (HP:0002812)1.99702246
141Protuberant abdomen (HP:0001538)1.98633953
142Decreased central vision (HP:0007663)1.98148490
143Genetic anticipation (HP:0003743)1.97641536
144Medial flaring of the eyebrow (HP:0010747)1.96572489
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95057467
146Tetany (HP:0001281)1.93639687
147Stomach cancer (HP:0012126)1.91284327
148Plantar hyperkeratosis (HP:0007556)1.90059997
149Congenital sensorineural hearing impairment (HP:0008527)1.89794322
150Platyspondyly (HP:0000926)1.89681937
151Abnormality of the proximal phalanges of the hand (HP:0009834)1.89134454
152Recurrent abscess formation (HP:0002722)1.88092283
153Congenital hepatic fibrosis (HP:0002612)1.87620532
154Onycholysis (HP:0001806)1.86703366
155Hypoplasia of the odontoid process (HP:0003311)1.86511087
156Metabolic acidosis (HP:0001942)1.86504946
157Osteoarthritis (HP:0002758)1.86457803
158Recurrent bacterial skin infections (HP:0005406)1.86015577
159Waddling gait (HP:0002515)1.85093932
160Abnormality of potassium homeostasis (HP:0011042)1.84897642
161Hypokalemic alkalosis (HP:0001949)1.84682478
162Hypoplastic ilia (HP:0000946)1.84615368
163Epistaxis (HP:0000421)1.83943694
164Bilateral sensorineural hearing impairment (HP:0008619)1.83555226
165Orchitis (HP:0100796)1.83411918
166Progressive cerebellar ataxia (HP:0002073)1.82908510
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82868766
168Type II lissencephaly (HP:0007260)1.81793012
169Myositis (HP:0100614)1.81402347
170Increased corneal curvature (HP:0100692)1.81307808
171Keratoconus (HP:0000563)1.81307808
172Limited elbow extension (HP:0001377)1.79928507
173Vertebral hypoplasia (HP:0008417)1.79809526
174Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79809526
175Widely patent fontanelles and sutures (HP:0004492)1.78946378
176IgM deficiency (HP:0002850)1.78541039
177Abnormality of eosinophils (HP:0001879)1.78476587
178Lethargy (HP:0001254)1.77541565
179Large for gestational age (HP:0001520)1.77394476
180Dicarboxylic aciduria (HP:0003215)1.77153326
181Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77153326
182Male pseudohermaphroditism (HP:0000037)1.77120801
183Hypobetalipoproteinemia (HP:0003563)1.76741999
184Milia (HP:0001056)1.76248532
185Heterochromia iridis (HP:0001100)1.75802792
186Bronchiectasis (HP:0002110)1.75268379
187Ileus (HP:0002595)1.74625277
188Hyperalaninemia (HP:0003348)1.74612487
189Abnormality of the 2nd finger (HP:0004100)1.72012706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.07194977
2MST44.48033161
3FRK3.75663208
4NME13.66215038
5KIT3.33913311
6EEF2K3.29284116
7ADRBK23.09469300
8TXK2.92922746
9MATK2.81189190
10MAP3K142.61494164
11PIM22.51542548
12TLK12.47598424
13STK392.46037719
14MAPKAPK32.38817647
15TRPM72.29104436
16WNK42.23990675
17MAP3K32.22944293
18STK242.19908929
19MST1R2.15209501
20IRAK32.14550553
21MAP4K22.12454332
22PRKG22.06673351
23INSRR1.92322949
24PINK11.86512558
25RIPK41.75526242
26MAP4K11.64254570
27DAPK21.47557009
28IRAK41.44736747
29NUAK11.43427777
30MAP3K121.40461646
31TAOK31.39635009
32SIK31.39433125
33STK101.38625672
34FGFR31.32624660
35RPS6KB21.28275239
36MAPK131.27142193
37TNIK1.26731797
38MAPKAPK51.24072309
39TEC1.22832181
40TYK21.19573463
41PTK61.17337064
42JAK31.17043709
43MUSK1.09750864
44PIM11.09558910
45ADRBK11.08775099
46BMPR21.07973543
47BMPR1B1.07457277
48SYK1.07019707
49PDK21.03365038
50ERBB31.03283556
51TBK11.02966535
52BTK1.02335862
53MAPK151.02095856
54STK30.96520154
55EPHA30.96271438
56PRKCE0.95188242
57NEK90.94847955
58CASK0.92146511
59IKBKB0.90734088
60GRK60.90560945
61MAPKAPK20.90387447
62ITK0.89626971
63WNK30.86223337
64MAP2K60.85752290
65CDK60.85250504
66GRK70.81287709
67MAP3K40.77770724
68LYN0.77382423
69YES10.74839645
70LMTK20.74561994
71CAMKK20.73042151
72ERBB20.72668403
73BCKDK0.72488147
74STK38L0.71878548
75PAK30.71836173
76OXSR10.71467295
77MAP3K70.69751650
78TIE10.68940624
79TRIM280.68645873
80CSF1R0.68060297
81PRKCQ0.68018286
82AKT30.66391318
83EPHB20.66368122
84EPHB10.66141653
85IKBKE0.65641934
86PRKAA20.65538820
87JAK20.65235955
88NLK0.65179877
89PLK20.64181059
90PIK3CG0.63326114
91CHUK0.63000913
92PRKCA0.62019511
93GRK10.61901389
94PTK2B0.60896623
95CDK30.60547393
96SGK30.59707662
97PHKG20.59524633
98PHKG10.59524633
99CSNK1A10.59066554
100ZAK0.56964209
101PIK3CA0.56714797
102NTRK30.56543366
103MAP3K110.55632087
104LCK0.55082548
105PRKACA0.55002908
106MAP2K20.54962424
107LRRK20.54299141
108FES0.53124375
109DDR20.52482030
110CAMK2A0.52258392
111MAP3K60.50383002
112SGK20.49366486
113MAP2K10.48503114
114IGF1R0.48243505
115PRKCI0.48139758
116FGFR20.47612867
117PRKCZ0.47555984
118PRKCG0.47451440
119MAPK110.47394433
120BRSK20.44565612
121MKNK20.43245859
122MAP3K50.42972340
123IRAK10.42754971
124EPHA40.42485947
125RPS6KA20.41236312
126EIF2AK30.41216389
127TAOK10.40991602
128PRKACG0.40458456
129DYRK1B0.39696036
130HCK0.39359162
131CSNK1G10.39123959
132CSNK1G20.38799470
133TGFBR10.36598626
134MYLK0.36494584
135CSK0.36270545
136TNK20.35581179
137TAOK20.35035336
138FER0.34839658
139GRK50.34659163
140PRKCD0.34228446
141CDK90.33603448
142JAK10.32226358
143CSNK1G30.32123747
144EIF2AK20.32071230
145PRKAA10.31913486
146PRKG10.31702431
147CAMK2D0.31491029
148PRKD20.31309529
149NME20.29778178
150ABL10.29726582
151MAP3K20.29433868
152NTRK20.28709937
153TGFBR20.28516225
154ZAP700.28310377
155MAPK40.28220231
156EPHA20.27789610

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046146.98217581
2Asthma_Homo sapiens_hsa053103.59551533
3Protein digestion and absorption_Homo sapiens_hsa049743.17300532
4Caffeine metabolism_Homo sapiens_hsa002322.59397285
5Mineral absorption_Homo sapiens_hsa049782.52507228
6Vitamin digestion and absorption_Homo sapiens_hsa049772.42134421
7Hematopoietic cell lineage_Homo sapiens_hsa046402.37968662
8Chemical carcinogenesis_Homo sapiens_hsa052042.25421048
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.21424916
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21305293
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20947051
12Retinol metabolism_Homo sapiens_hsa008302.01896964
13Sulfur metabolism_Homo sapiens_hsa009201.98216007
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95616654
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92820734
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.88559105
17Fat digestion and absorption_Homo sapiens_hsa049751.85300096
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.80949198
19Sphingolipid metabolism_Homo sapiens_hsa006001.80871927
20Nitrogen metabolism_Homo sapiens_hsa009101.76013791
21Ether lipid metabolism_Homo sapiens_hsa005651.72162961
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60006858
23ECM-receptor interaction_Homo sapiens_hsa045121.59758415
24Arachidonic acid metabolism_Homo sapiens_hsa005901.56343351
25Butanoate metabolism_Homo sapiens_hsa006501.55699101
26Allograft rejection_Homo sapiens_hsa053301.51068104
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44877442
28Autoimmune thyroid disease_Homo sapiens_hsa053201.44850626
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43335609
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41466196
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38939507
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37484496
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37322861
34Glycerolipid metabolism_Homo sapiens_hsa005611.36260731
35Phototransduction_Homo sapiens_hsa047441.34904745
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.31021261
37Toxoplasmosis_Homo sapiens_hsa051451.29365881
38Other glycan degradation_Homo sapiens_hsa005111.27311688
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23646296
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22664225
41Leishmaniasis_Homo sapiens_hsa051401.21625770
42Platelet activation_Homo sapiens_hsa046111.20969594
43Graft-versus-host disease_Homo sapiens_hsa053321.20128037
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17953417
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.17149767
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15508065
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.14181151
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.14127744
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12445905
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10477339
51Ovarian steroidogenesis_Homo sapiens_hsa049131.09514418
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09250034
53Fatty acid degradation_Homo sapiens_hsa000711.06036911
54Osteoclast differentiation_Homo sapiens_hsa043801.05499602
55Peroxisome_Homo sapiens_hsa041461.04367105
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03854554
57PPAR signaling pathway_Homo sapiens_hsa033201.03850542
58Type I diabetes mellitus_Homo sapiens_hsa049401.02274079
59Galactose metabolism_Homo sapiens_hsa000521.02001483
60ABC transporters_Homo sapiens_hsa020100.97002558
61Apoptosis_Homo sapiens_hsa042100.96716188
62Pancreatic secretion_Homo sapiens_hsa049720.95639535
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95441785
64Insulin secretion_Homo sapiens_hsa049110.95093322
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94541248
66Oxidative phosphorylation_Homo sapiens_hsa001900.92314991
67TNF signaling pathway_Homo sapiens_hsa046680.92137754
68Starch and sucrose metabolism_Homo sapiens_hsa005000.90701716
69Propanoate metabolism_Homo sapiens_hsa006400.89507672
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85785208
71Selenocompound metabolism_Homo sapiens_hsa004500.85140344
72Primary immunodeficiency_Homo sapiens_hsa053400.84221929
73Measles_Homo sapiens_hsa051620.84058941
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.83573866
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81297964
76Hepatitis B_Homo sapiens_hsa051610.80101482
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79508563
78Arginine and proline metabolism_Homo sapiens_hsa003300.79202418
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78493340
80Inositol phosphate metabolism_Homo sapiens_hsa005620.75707223
81Influenza A_Homo sapiens_hsa051640.75275813
82Arginine biosynthesis_Homo sapiens_hsa002200.74867853
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74447328
84Legionellosis_Homo sapiens_hsa051340.74139808
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.73761601
86Glutathione metabolism_Homo sapiens_hsa004800.73399816
87Nicotine addiction_Homo sapiens_hsa050330.73188215
88B cell receptor signaling pathway_Homo sapiens_hsa046620.71139224
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69654169
90Histidine metabolism_Homo sapiens_hsa003400.69575143
91Tuberculosis_Homo sapiens_hsa051520.69365373
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.66747312
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66392565
94Acute myeloid leukemia_Homo sapiens_hsa052210.66066833
95Taste transduction_Homo sapiens_hsa047420.65789303
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63901490
97Renin secretion_Homo sapiens_hsa049240.62806927
98N-Glycan biosynthesis_Homo sapiens_hsa005100.61194912
99Malaria_Homo sapiens_hsa051440.61177967
100Small cell lung cancer_Homo sapiens_hsa052220.59937023
101Staphylococcus aureus infection_Homo sapiens_hsa051500.59046490
102Hepatitis C_Homo sapiens_hsa051600.58247312
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58246198
104Salmonella infection_Homo sapiens_hsa051320.58104679
105beta-Alanine metabolism_Homo sapiens_hsa004100.57749603
106Salivary secretion_Homo sapiens_hsa049700.57671462
107African trypanosomiasis_Homo sapiens_hsa051430.57198890
108Thyroid hormone synthesis_Homo sapiens_hsa049180.56440251
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55844787
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55467890
111Metabolic pathways_Homo sapiens_hsa011000.55354089
112Collecting duct acid secretion_Homo sapiens_hsa049660.54840363
113Serotonergic synapse_Homo sapiens_hsa047260.54568859
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.53762319
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53650546
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52996706
117Vibrio cholerae infection_Homo sapiens_hsa051100.52851560
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52539613
119Bile secretion_Homo sapiens_hsa049760.51043006
120Tyrosine metabolism_Homo sapiens_hsa003500.49766229
121* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49395321
122Shigellosis_Homo sapiens_hsa051310.47681596
123Chemokine signaling pathway_Homo sapiens_hsa040620.46626769
124Olfactory transduction_Homo sapiens_hsa047400.44277008
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43964491
126Pertussis_Homo sapiens_hsa051330.43843799
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42840284
128Homologous recombination_Homo sapiens_hsa034400.42808518
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42709419
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.42631949
131p53 signaling pathway_Homo sapiens_hsa041150.41850824
132Parkinsons disease_Homo sapiens_hsa050120.41685649
133Fatty acid metabolism_Homo sapiens_hsa012120.41544377
134Focal adhesion_Homo sapiens_hsa045100.41355293
135Antigen processing and presentation_Homo sapiens_hsa046120.40945163
136* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40699182
137Huntingtons disease_Homo sapiens_hsa050160.40465157
138Regulation of autophagy_Homo sapiens_hsa041400.40356525
139Morphine addiction_Homo sapiens_hsa050320.39565729
140Fructose and mannose metabolism_Homo sapiens_hsa000510.37519726
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37449644
142Alzheimers disease_Homo sapiens_hsa050100.36821057
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36766487
144Herpes simplex infection_Homo sapiens_hsa051680.36299630
145Circadian entrainment_Homo sapiens_hsa047130.35896710
146Sulfur relay system_Homo sapiens_hsa041220.35728357
147MicroRNAs in cancer_Homo sapiens_hsa052060.35104732
148Tryptophan metabolism_Homo sapiens_hsa003800.35028013
149Chronic myeloid leukemia_Homo sapiens_hsa052200.34833751
150Rheumatoid arthritis_Homo sapiens_hsa053230.34796381
151Protein export_Homo sapiens_hsa030600.33212927
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32299205
153Glutamatergic synapse_Homo sapiens_hsa047240.32088545
154T cell receptor signaling pathway_Homo sapiens_hsa046600.31524236
155Linoleic acid metabolism_Homo sapiens_hsa005910.31490632
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.31064125
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30925039
158Rap1 signaling pathway_Homo sapiens_hsa040150.30156216
159Fatty acid biosynthesis_Homo sapiens_hsa000610.29917339
160Vascular smooth muscle contraction_Homo sapiens_hsa042700.28466868

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