ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitotic sister chromatid segregation (GO:0000070)	4.65797583
2	mitotic chromosome condensation (GO:0007076)	4.44257150
3	DNA synthesis involved in DNA repair (GO:0000731)	4.43613574
4	sister chromatid segregation (GO:0000819)	4.34420250
5	mitotic sister chromatid cohesion (GO:0007064)	4.30365443
6	regulation of DNA endoreduplication (GO:0032875)	4.27585611
7	negative regulation of fibrinolysis (GO:0051918)	4.21806813
8	regulation of protein activation cascade (GO:2000257)	4.01393469
9	very-low-density lipoprotein particle assembly (GO:0034379)	3.98545313
10	chromosome organization involved in meiosis (GO:0070192)	3.93182177
11	protein localization to kinetochore (GO:0034501)	3.92634332
12	regulation of complement activation (GO:0030449)	3.92419104
13	protein localization to chromosome, centromeric region (GO:0071459)	3.77019239
14	regulation of fibrinolysis (GO:0051917)	3.75360089
15	sister chromatid cohesion (GO:0007062)	3.71029019
16	synapsis (GO:0007129)	3.70694283
17	embryonic skeletal joint morphogenesis (GO:0060272)	3.52334418
18	synaptonemal complex assembly (GO:0007130)	3.49038575
19	negative regulation of protein activation cascade (GO:2000258)	3.47404248
20	protein carboxylation (GO:0018214)	3.46659841
21	peptidyl-glutamic acid carboxylation (GO:0017187)	3.46659841
22	nuclear pore complex assembly (GO:0051292)	3.43434109
23	nuclear pore organization (GO:0006999)	3.41638476
24	plasma lipoprotein particle assembly (GO:0034377)	3.36730906
25	attachment of spindle microtubules to kinetochore (GO:0008608)	3.34821519
26	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.31897181
27	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.31897181
28	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.31897181
29	blood coagulation, intrinsic pathway (GO:0007597)	3.31738595
30	cholesterol efflux (GO:0033344)	3.19664274
31	regulation of sister chromatid cohesion (GO:0007063)	3.17959947
32	DNA packaging (GO:0006323)	3.13811413
33	telomere maintenance via semi-conservative replication (GO:0032201)	3.12888737
34	low-density lipoprotein particle remodeling (GO:0034374)	3.10057735
35	intestinal cholesterol absorption (GO:0030299)	3.09801851
36	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.08947015
37	synaptonemal complex organization (GO:0070193)	3.08203016
38	protein-lipid complex assembly (GO:0065005)	3.07412492
39	negative regulation of complement activation (GO:0045916)	3.07136598
40	DNA replication checkpoint (GO:0000076)	3.05889881
41	chromosome condensation (GO:0030261)	3.05264285
42	DNA strand elongation involved in DNA replication (GO:0006271)	3.02919123
43	protein localization to chromosome (GO:0034502)	2.99132741
44	DNA strand elongation (GO:0022616)	2.97497898
45	kinetochore organization (GO:0051383)	2.96998255
46	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.96709838
47	L-phenylalanine catabolic process (GO:0006559)	2.96709838
48	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.90282985
49	L-phenylalanine metabolic process (GO:0006558)	2.85953892
50	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.85953892
51	positive regulation of cell cycle checkpoint (GO:1901978)	2.82967672
52	macromolecular complex remodeling (GO:0034367)	2.81101649
53	plasma lipoprotein particle remodeling (GO:0034369)	2.81101649
54	protein-lipid complex remodeling (GO:0034368)	2.81101649
55	maturation of SSU-rRNA (GO:0030490)	2.81030888
56	meiotic chromosome segregation (GO:0045132)	2.80786513
57	lymph vessel development (GO:0001945)	2.76523080
58	regulation of cholesterol esterification (GO:0010872)	2.76398112
59	meiotic nuclear division (GO:0007126)	2.75023615
60	tetrahydrofolate metabolic process (GO:0046653)	2.72006367
61	male meiosis I (GO:0007141)	2.70951786
62	chromatin remodeling at centromere (GO:0031055)	2.69972774
63	embryonic heart tube development (GO:0035050)	2.69768955
64	translesion synthesis (GO:0019985)	2.69622963
65	mitotic metaphase plate congression (GO:0007080)	2.69400635
66	folic acid-containing compound biosynthetic process (GO:0009396)	2.68424850
67	telomere maintenance via recombination (GO:0000722)	2.68087540
68	regulation of heart morphogenesis (GO:2000826)	2.67237779
69	CENP-A containing nucleosome assembly (GO:0034080)	2.65258900
70	metaphase plate congression (GO:0051310)	2.64507633
71	ribosomal small subunit biogenesis (GO:0042274)	2.64344758
72	positive regulation of chromosome segregation (GO:0051984)	2.63922690
73	mitotic nuclear envelope disassembly (GO:0007077)	2.57355736
74	plasma lipoprotein particle organization (GO:0071827)	2.56674422
75	regulation of meiosis I (GO:0060631)	2.55931588
76	DNA replication initiation (GO:0006270)	2.55529553
77	forelimb morphogenesis (GO:0035136)	2.55482006
78	DNA unwinding involved in DNA replication (GO:0006268)	2.55163200
79	proximal/distal pattern formation (GO:0009954)	2.54634496
80	high-density lipoprotein particle remodeling (GO:0034375)	2.52058014
81	histone-serine phosphorylation (GO:0035404)	2.50678693
82	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.49543432
83	meiotic cell cycle process (GO:1903046)	2.48489026
84	spindle checkpoint (GO:0031577)	2.48183316
85	nuclear envelope disassembly (GO:0051081)	2.46724444
86	membrane disassembly (GO:0030397)	2.46724444
87	regulation of mitotic spindle organization (GO:0060236)	2.45874723
88	protein-lipid complex subunit organization (GO:0071825)	2.45534468
89	mitotic recombination (GO:0006312)	2.44185436
90	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.43569748
91	protein localization to microtubule (GO:0035372)	2.42661075
92	fibrinolysis (GO:0042730)	2.42423671
93	reproductive system development (GO:0061458)	2.41131267
94	chromosome segregation (GO:0007059)	2.41030767
95	embryonic forelimb morphogenesis (GO:0035115)	2.40899329
96	pore complex assembly (GO:0046931)	2.40756472
97	postreplication repair (GO:0006301)	2.39976641
98	regulation of mitochondrial translation (GO:0070129)	2.38542968
99	complement activation, alternative pathway (GO:0006957)	2.37411656
100	ventricular septum morphogenesis (GO:0060412)	2.37188720

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.84546435
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.86108564
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.94035204
4	AR_21909140_ChIP-Seq_LNCAP_Human	3.54418637
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.44494465
6	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.26519933
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.12934595
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.99804375
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.75497746
10	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.72144371
11	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.71007829
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.69379751
13	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.59635193
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50802922
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.47630371
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.43125685
17	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.42054242
18	* PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.33416234
19	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.13611972
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.11453744
21	XRN2_22483619_ChIP-Seq_HELA_Human	2.11208438
22	FUS_26573619_Chip-Seq_HEK293_Human	2.07895979
23	TTF2_22483619_ChIP-Seq_HELA_Human	2.02934871
24	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.97776011
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93956125
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.92044471
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.82802616
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.81091894
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80349914
30	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.73222519
31	EWS_26573619_Chip-Seq_HEK293_Human	1.70334456
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.69409575
33	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.65610959
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.64430596
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.63528747
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.61502397
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.56870984
38	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.54356916
39	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.53553129
40	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.52395755
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.52038036
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.50608651
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50239526
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49674868
45	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.48842482
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.47282699
47	KDM5A_27292631_Chip-Seq_BREAST_Human	1.46870604
48	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.44707640
49	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.44047131
50	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.40062338
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.35928505
52	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.35824766
53	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.35458759
54	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.33595896
55	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.32058691
56	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29076393
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25694546
58	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23643095
59	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22483913
60	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.20439827
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.20339632
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.19215454
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.18999485
64	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18772591
65	* GABP_19822575_ChIP-Seq_HepG2_Human	1.18003151
66	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15855422
67	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.14545322
68	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.13120362
69	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.12300229
70	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.10490482
71	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09720192
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07644614
73	MYC_18940864_ChIP-ChIP_HL60_Human	1.06257983
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05247230
75	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.03707690
76	* PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.03233456
77	FOXP3_21729870_ChIP-Seq_TREG_Human	0.98979124
78	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.98451156
79	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.98381498
80	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.97831730
81	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97520908
82	TAF15_26573619_Chip-Seq_HEK293_Human	0.95128959
83	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95054975
84	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.93332438
85	CLOCK_20551151_ChIP-Seq_293T_Human	0.93081322
86	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.92791204
87	TFEB_21752829_ChIP-Seq_HELA_Human	0.89654873
88	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.87920502
89	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.87873788
90	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.87050826
91	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.86716131
92	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.83614310
93	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.82798784
94	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.82481204
95	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.82328779
96	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.82251495
97	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.82166699
98	CHD1_26751641_Chip-Seq_LNCaP_Human	0.82010052
99	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.79966542
100	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.79896015

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	3.82007322
2	MP0008057_abnormal_DNA_replication	3.75234223
3	MP0010094_abnormal_chromosome_stability	3.28190384
4	MP0002009_preneoplasia	2.96345789
5	MP0005187_abnormal_penis_morphology	2.93565102
6	MP0003111_abnormal_nucleus_morphology	2.78050239
7	MP0008058_abnormal_DNA_repair	2.77851096
8	MP0003077_abnormal_cell_cycle	2.59018703
9	MP0003195_calcinosis	2.54935458
10	MP0008007_abnormal_cellular_replicative	2.35927178
11	MP0005623_abnormal_meninges_morphology	2.28089690
12	MP0003315_abnormal_perineum_morphology	2.27608862
13	MP0000566_synostosis	2.20141741
14	MP0009697_abnormal_copulation	2.14149221
15	MP0001346_abnormal_lacrimal_gland	2.04682654
16	MP0002160_abnormal_reproductive_system	1.99421022
17	MP0000537_abnormal_urethra_morphology	1.98401617
18	MP0003693_abnormal_embryo_hatching	1.94746358
19	MP0005365_abnormal_bile_salt	1.92443629
20	MP0010368_abnormal_lymphatic_system	1.85098449
21	MP0005360_urolithiasis	1.77793441
22	MP0002234_abnormal_pharynx_morphology	1.69516221
23	MP0002938_white_spotting	1.68625213
24	MP0008932_abnormal_embryonic_tissue	1.65708590
25	MP0010030_abnormal_orbit_morphology	1.58219564
26	MP0001270_distended_abdomen	1.57143950
27	MP0005408_hypopigmentation	1.55798667
28	MP0002249_abnormal_larynx_morphology	1.51203416
29	MP0001666_abnormal_nutrient_absorption	1.50624190
30	MP0003937_abnormal_limbs/digits/tail_de	1.49443424
31	MP0002210_abnormal_sex_determination	1.48077247
32	MP0002697_abnormal_eye_size	1.46744037
33	MP0002092_abnormal_eye_morphology	1.38863721
34	MP0006292_abnormal_olfactory_placode	1.37802271
35	MP0005085_abnormal_gallbladder_physiolo	1.36630499
36	MP0001929_abnormal_gametogenesis	1.36085954
37	MP0009053_abnormal_anal_canal	1.33845584
38	MP0003942_abnormal_urinary_system	1.29885288
39	MP0004957_abnormal_blastocyst_morpholog	1.26617056
40	MP0001661_extended_life_span	1.23630163
41	MP0001286_abnormal_eye_development	1.21654632
42	MP0003123_paternal_imprinting	1.20611493
43	MP0000653_abnormal_sex_gland	1.20478297
44	MP0001145_abnormal_male_reproductive	1.19326469
45	MP0003718_maternal_effect	1.18327204
46	MP0003943_abnormal_hepatobiliary_system	1.16669981
47	MP0000003_abnormal_adipose_tissue	1.15975652
48	MP0004272_abnormal_basement_membrane	1.15729610
49	MP0010307_abnormal_tumor_latency	1.15424511
50	MP0001293_anophthalmia	1.14679915
51	MP0000350_abnormal_cell_proliferation	1.14057122
52	MP0002233_abnormal_nose_morphology	1.12646529
53	MP0005380_embryogenesis_phenotype	1.12492848
54	MP0001672_abnormal_embryogenesis/_devel	1.12492848
55	MP0002282_abnormal_trachea_morphology	1.12013109
56	MP0003122_maternal_imprinting	1.11935063
57	MP0003786_premature_aging	1.11893054
58	MP0003252_abnormal_bile_duct	1.11336629
59	MP0001697_abnormal_embryo_size	1.10254518
60	MP0002138_abnormal_hepatobiliary_system	1.10070868
61	MP0008995_early_reproductive_senescence	1.09807436
62	MP0002928_abnormal_bile_duct	1.09251371
63	MP0009250_abnormal_appendicular_skeleto	1.07529406
64	MP0005389_reproductive_system_phenotype	1.07268800
65	MP0001730_embryonic_growth_arrest	1.06707724
66	MP0010329_abnormal_lipoprotein_level	1.05587642
67	MP0005367_renal/urinary_system_phenotyp	1.04537451
68	MP0000516_abnormal_urinary_system	1.04537451
69	MP0003136_yellow_coat_color	1.04222694
70	MP0001879_abnormal_lymphatic_vessel	1.04196119
71	MP0001324_abnormal_eye_pigmentation	1.03403754
72	MP0010352_gastrointestinal_tract_polyps	1.00451055
73	MP0003984_embryonic_growth_retardation	0.99446763
74	MP0003950_abnormal_plasma_membrane	0.99140945
75	MP0000049_abnormal_middle_ear	0.99038883
76	MP0003868_abnormal_feces_composition	0.98737733
77	MP0000534_abnormal_ureter_morphology	0.98343699
78	MP0002088_abnormal_embryonic_growth/wei	0.95869091
79	MP0003890_abnormal_embryonic-extraembry	0.95515922
80	MP0002084_abnormal_developmental_patter	0.95060703
81	MP0005076_abnormal_cell_differentiation	0.94723304
82	MP0003755_abnormal_palate_morphology	0.94133648
83	MP0003698_abnormal_male_reproductive	0.91942466
84	MP0002163_abnormal_gland_morphology	0.91917956
85	MP0003699_abnormal_female_reproductive	0.91890277
86	MP0004233_abnormal_muscle_weight	0.91691781
87	MP0000762_abnormal_tongue_morphology	0.91395743
88	MP0008875_abnormal_xenobiotic_pharmacok	0.90612964
89	MP0001764_abnormal_homeostasis	0.85796771
90	MP0002085_abnormal_embryonic_tissue	0.85283561
91	MP0001915_intracranial_hemorrhage	0.84689875
92	MP0002161_abnormal_fertility/fecundity	0.84627365
93	MP0003935_abnormal_craniofacial_develop	0.83611869
94	MP0001119_abnormal_female_reproductive	0.80071025
95	MP0005391_vision/eye_phenotype	0.79304636
96	MP0000733_abnormal_muscle_development	0.78760497
97	MP0000013_abnormal_adipose_tissue	0.75671022
98	MP0005409_darkened_coat_color	0.75646311
99	MP0003119_abnormal_digestive_system	0.73687194
100	MP0002932_abnormal_joint_morphology	0.72223153

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	5.49341515
2	Hypobetalipoproteinemia (HP:0003563)	4.12525753
3	Prolonged partial thromboplastin time (HP:0003645)	3.82069708
4	Chromsome breakage (HP:0040012)	3.79728732
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.74302713
6	Volvulus (HP:0002580)	3.53277618
7	Spontaneous abortion (HP:0005268)	3.41800784
8	Abnormal tarsal ossification (HP:0008369)	3.36171178
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.30293745
10	Small epiphyses (HP:0010585)	3.24030312
11	11 pairs of ribs (HP:0000878)	3.15661190
12	Abnormality of carpal bone ossification (HP:0006257)	2.90933920
13	Abnormal foot bone ossification (HP:0010675)	2.79799793
14	Septate vagina (HP:0001153)	2.76802066
15	Abnormality of the phalanges of the hallux (HP:0010057)	2.74765605
16	Osteomalacia (HP:0002749)	2.63210794
17	Complement deficiency (HP:0004431)	2.62944707
18	Meckel diverticulum (HP:0002245)	2.57763057
19	Facial hemangioma (HP:0000329)	2.57625480
20	Rectal prolapse (HP:0002035)	2.52488172
21	Abnormal hand bone ossification (HP:0010660)	2.52226299
22	Abnormality of the ileum (HP:0001549)	2.47406300
23	Abnormality of the common coagulation pathway (HP:0010990)	2.44234537
24	Capillary hemangiomas (HP:0005306)	2.44186981
25	Azoospermia (HP:0000027)	2.37682660
26	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.35666861
27	Hypolipoproteinemia (HP:0010981)	2.35097765
28	Transposition of the great arteries (HP:0001669)	2.32918751
29	Abnormal connection of the cardiac segments (HP:0011545)	2.32918751
30	Abnormal ventriculo-arterial connection (HP:0011563)	2.32918751
31	Abnormal ossification of hand bones (HP:0005921)	2.32324822
32	Mitral stenosis (HP:0001718)	2.31690463
33	Abnormality of chromosome stability (HP:0003220)	2.30703563
34	Bifid scrotum (HP:0000048)	2.30622236
35	Joint hemorrhage (HP:0005261)	2.28936520
36	Increased nuchal translucency (HP:0010880)	2.25508668
37	Midline defect of the nose (HP:0004122)	2.25270362
38	Proximal placement of thumb (HP:0009623)	2.25254008
39	Acanthocytosis (HP:0001927)	2.24399748
40	Megaloblastic anemia (HP:0001889)	2.16515958
41	Reticulocytopenia (HP:0001896)	2.16070770
42	Increased serum pyruvate (HP:0003542)	2.16011728
43	Limited elbow extension (HP:0001377)	2.15479796
44	Hypercholesterolemia (HP:0003124)	2.14453233
45	Preauricular pit (HP:0004467)	2.13093380
46	Periauricular skin pits (HP:0100277)	2.13093380
47	Abnormality of glycolysis (HP:0004366)	2.10281200
48	Abnormal lung lobation (HP:0002101)	2.08344813
49	Deviation of the thumb (HP:0009603)	2.08108379
50	Abnormality of the nasal septum (HP:0000419)	2.07108288
51	Abnormal number of incisors (HP:0011064)	2.04301499
52	Broad palm (HP:0001169)	2.03994279
53	Ectopic kidney (HP:0000086)	2.03967058
54	Absent eyebrow (HP:0002223)	2.03820124
55	Nephroblastoma (Wilms tumor) (HP:0002667)	2.02568740
56	Overlapping toe (HP:0001845)	2.01066458
57	Glomerulonephritis (HP:0000099)	1.97000896
58	Supernumerary spleens (HP:0009799)	1.96594646
59	Deformed tarsal bones (HP:0008119)	1.95041815
60	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94220164
61	Nausea (HP:0002018)	1.93169885
62	Abnormal spermatogenesis (HP:0008669)	1.91684980
63	Abnormality of chromosome segregation (HP:0002916)	1.91132891
64	Epidermoid cyst (HP:0200040)	1.89411149
65	Renal cortical cysts (HP:0000803)	1.88862089
66	Neonatal death (HP:0003811)	1.88814739
67	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.86307020
68	Abnormality of the preputium (HP:0100587)	1.85681483
69	Generalized aminoaciduria (HP:0002909)	1.85445370
70	Macrocytic anemia (HP:0001972)	1.85031578
71	Gout (HP:0001997)	1.84861924
72	Abnormality of cochlea (HP:0000375)	1.84220953
73	Calcaneovalgus deformity (HP:0001848)	1.83976968
74	Vaginal fistula (HP:0004320)	1.83807169
75	Embryonal renal neoplasm (HP:0011794)	1.83186315
76	Short thumb (HP:0009778)	1.82614174
77	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.79256853
78	Absent epiphyses (HP:0010577)	1.79256853
79	Abnormality of methionine metabolism (HP:0010901)	1.78647838
80	Large hands (HP:0001176)	1.78439471
81	Rectal fistula (HP:0100590)	1.77861222
82	Rectovaginal fistula (HP:0000143)	1.77861222
83	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.77688430
84	Vascular calcification (HP:0004934)	1.76848142
85	Fibular hypoplasia (HP:0003038)	1.76060832
86	Absent radius (HP:0003974)	1.75662420
87	Dislocated radial head (HP:0003083)	1.75461898
88	Duplication of thumb phalanx (HP:0009942)	1.74661355
89	Papillary thyroid carcinoma (HP:0002895)	1.74023548
90	Abnormality of complement system (HP:0005339)	1.72605819
91	Triphalangeal thumb (HP:0001199)	1.71153244
92	Gonadotropin excess (HP:0000837)	1.67438499
93	3-Methylglutaconic aciduria (HP:0003535)	1.64607643
94	Skin pits (HP:0100276)	1.63949466
95	Abnormality of the radial head (HP:0003995)	1.63703165
96	Intestinal fistula (HP:0100819)	1.63645122
97	Abnormality of the calcaneus (HP:0008364)	1.63466503
98	Fair hair (HP:0002286)	1.59561981
99	Bifid tongue (HP:0010297)	1.59250360
100	Small intestinal stenosis (HP:0012848)	1.59057332

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.01312993
2	BUB1	3.32708240
3	WEE1	3.31034295
4	PDK2	3.11757855
5	CDK12	2.78779634
6	IRAK3	2.39999052
7	TSSK6	2.34710201
8	SRPK1	2.23126465
9	NEK1	2.16557700
10	BRSK2	2.09823711
11	MAPK15	2.09450407
12	CAMK1G	1.99072313
13	BRD4	1.91363922
14	LATS1	1.88918659
15	AKT3	1.88180299
16	NEK9	1.83393525
17	CDK8	1.81144841
18	CDC7	1.78712294
19	TTK	1.65557972
20	TRIB3	1.55097833
21	EIF2AK1	1.52719511
22	PLK3	1.45766195
23	FGFR3	1.42782032
24	ATR	1.39686895
25	CHEK2	1.37988772
26	STK16	1.34789653
27	BRSK1	1.32218161
28	CDK7	1.30162817
29	PLK1	1.19431491
30	TYRO3	1.18504577
31	CDK3	1.15777222
32	CHEK1	1.14946918
33	MELK	1.13607172
34	PLK4	1.11793809
35	VRK1	1.11151398
36	FGFR4	1.07688092
37	EIF2AK3	1.07135262
38	ERBB3	1.07099544
39	IRAK2	1.04627312
40	ICK	1.03367819
41	EPHB2	0.99324789
42	NEK2	0.98832381
43	EEF2K	0.96781784
44	CAMK1D	0.95804595
45	CDK9	0.95287822
46	CAMKK2	0.93390522
47	ATM	0.91509265
48	PASK	0.90529051
49	AURKB	0.90249354
50	CCNB1	0.88637908
51	LMTK2	0.86242224
52	WNK4	0.85759258
53	PDGFRA	0.83744404
54	BMPR1B	0.79504999
55	FGFR1	0.76341402
56	CDK6	0.75794517
57	CDK4	0.75593641
58	FGFR2	0.71288499
59	STK3	0.68721656
60	CSNK1E	0.65462841
61	AURKA	0.64585671
62	MKNK1	0.63858244
63	TRIM28	0.63172187
64	MET	0.61702678
65	STK39	0.61239965
66	IRAK1	0.59376979
67	CDK1	0.57563699
68	MAPKAPK5	0.57513715
69	DYRK3	0.56272083
70	MST1R	0.54842796
71	MARK3	0.54806165
72	CDK2	0.53156702
73	EIF2AK2	0.52357040
74	NEK6	0.52187393
75	PHKG2	0.50759102
76	PHKG1	0.50759102
77	MKNK2	0.49243004
78	MAPK11	0.48257808
79	DDR2	0.47238126
80	BRAF	0.46562651
81	MAP3K10	0.46101124
82	PRKAA2	0.45459824
83	TAF1	0.44767549
84	GSK3A	0.43779485
85	CSNK2A2	0.43361111
86	RPS6KB1	0.43193905
87	CSNK2A1	0.42979063
88	PBK	0.41153073
89	PDGFRB	0.40312576
90	PIK3CA	0.39179108
91	SIK2	0.38413599
92	PRKD3	0.38185569
93	PRKDC	0.37745567
94	VRK2	0.37100100
95	PRKACB	0.36547751
96	NUAK1	0.36082121
97	PRKAA1	0.35298286
98	CSNK1G1	0.35007009
99	CASK	0.34053702
100	SGK2	0.32800019

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.23551999
2	Complement and coagulation cascades_Homo sapiens_hsa04610	3.10836715
3	DNA replication_Homo sapiens_hsa03030	2.97978625
4	Mismatch repair_Homo sapiens_hsa03430	2.62787391
5	One carbon pool by folate_Homo sapiens_hsa00670	2.35243192
6	Cell cycle_Homo sapiens_hsa04110	2.24242669
7	Nucleotide excision repair_Homo sapiens_hsa03420	2.23367681
8	Homologous recombination_Homo sapiens_hsa03440	2.18468910
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.06101206
10	Non-homologous end-joining_Homo sapiens_hsa03450	1.93891686
11	Phenylalanine metabolism_Homo sapiens_hsa00360	1.88803250
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.77856750
13	Spliceosome_Homo sapiens_hsa03040	1.65455661
14	RNA transport_Homo sapiens_hsa03013	1.64074616
15	Circadian rhythm_Homo sapiens_hsa04710	1.57716674
16	Folate biosynthesis_Homo sapiens_hsa00790	1.56686212
17	Ribosome_Homo sapiens_hsa03010	1.55877343
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.55098237
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.50044394
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49411848
21	Sulfur relay system_Homo sapiens_hsa04122	1.49187333
22	RNA polymerase_Homo sapiens_hsa03020	1.45560208
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.38843901
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37034074
25	Basal transcription factors_Homo sapiens_hsa03022	1.36637684
26	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.33965789
27	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.33326259
28	Arginine biosynthesis_Homo sapiens_hsa00220	1.26854337
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24167547
30	RNA degradation_Homo sapiens_hsa03018	1.24028016
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22428411
32	Base excision repair_Homo sapiens_hsa03410	1.21605163
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.21410907
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.20201134
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.18760260
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18434236
37	mRNA surveillance pathway_Homo sapiens_hsa03015	1.16264616
38	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.14322154
39	Lysine degradation_Homo sapiens_hsa00310	1.14314621
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.14085073
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.12547534
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.11890081
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09194289
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.08420605
45	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05903090
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05795428
47	Fatty acid degradation_Homo sapiens_hsa00071	1.02897463
48	Selenocompound metabolism_Homo sapiens_hsa00450	1.02397435
49	Propanoate metabolism_Homo sapiens_hsa00640	0.99617240
50	Oocyte meiosis_Homo sapiens_hsa04114	0.99282289
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.97220091
52	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94734279
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.93562518
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92987616
55	p53 signaling pathway_Homo sapiens_hsa04115	0.91052760
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.89685958
57	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.87803867
58	Purine metabolism_Homo sapiens_hsa00230	0.85495135
59	Basal cell carcinoma_Homo sapiens_hsa05217	0.85125398
60	Fatty acid elongation_Homo sapiens_hsa00062	0.84124718
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82334400
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.81883144
63	Prion diseases_Homo sapiens_hsa05020	0.81382028
64	Retinol metabolism_Homo sapiens_hsa00830	0.81164873
65	PPAR signaling pathway_Homo sapiens_hsa03320	0.81038347
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80743313
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.79922910
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77290038
69	Bile secretion_Homo sapiens_hsa04976	0.71975653
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.70795345
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69838727
72	Huntingtons disease_Homo sapiens_hsa05016	0.69665251
73	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.69037102
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67823602
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.67809168
76	Small cell lung cancer_Homo sapiens_hsa05222	0.66873836
77	Protein export_Homo sapiens_hsa03060	0.63304242
78	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.62198125
79	ABC transporters_Homo sapiens_hsa02010	0.61457406
80	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.60640362
81	Glucagon signaling pathway_Homo sapiens_hsa04922	0.56330589
82	Proteasome_Homo sapiens_hsa03050	0.56005723
83	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.54958468
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.54653304
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.54269317
86	FoxO signaling pathway_Homo sapiens_hsa04068	0.54232118
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.53789998
88	Sulfur metabolism_Homo sapiens_hsa00920	0.53576061
89	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51479076
90	Parkinsons disease_Homo sapiens_hsa05012	0.50850649
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50528554
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.50412792
93	Carbon metabolism_Homo sapiens_hsa01200	0.50055192
94	Histidine metabolism_Homo sapiens_hsa00340	0.48227792
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.47401100
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45695310
97	Butanoate metabolism_Homo sapiens_hsa00650	0.44265847
98	Oxidative phosphorylation_Homo sapiens_hsa00190	0.43233970
99	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.42925547
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42129611

SCML1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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