SCML2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.37305264
2synaptonemal complex assembly (GO:0007130)8.71988507
3male meiosis (GO:0007140)8.05106734
4synaptonemal complex organization (GO:0070193)8.01303820
5meiotic nuclear division (GO:0007126)6.79054864
6chromosome organization involved in meiosis (GO:0070192)6.37692642
7male meiosis I (GO:0007141)6.14401778
8gene silencing by RNA (GO:0031047)5.66427004
9meiotic chromosome segregation (GO:0045132)5.61078891
10positive regulation of meiosis (GO:0045836)5.50331377
11DNA methylation (GO:0006306)5.46459464
12DNA alkylation (GO:0006305)5.46459464
13attachment of spindle microtubules to kinetochore (GO:0008608)5.35016602
14meiosis I (GO:0007127)5.29128428
15negative regulation of meiosis (GO:0045835)5.26356003
16positive regulation of meiotic cell cycle (GO:0051446)5.19967377
17nuclear pore complex assembly (GO:0051292)5.18534936
18oogenesis (GO:0048477)5.06395782
19nuclear pore organization (GO:0006999)5.04027217
20meiotic cell cycle process (GO:1903046)5.00359608
21mitotic chromosome condensation (GO:0007076)4.89562129
22reciprocal DNA recombination (GO:0035825)4.74333224
23reciprocal meiotic recombination (GO:0007131)4.74333224
24female gamete generation (GO:0007292)4.64538877
25sister chromatid cohesion (GO:0007062)4.52407909
26DNA synthesis involved in DNA repair (GO:0000731)4.48304788
27oocyte maturation (GO:0001556)4.35553378
28oocyte development (GO:0048599)4.27291894
29regulation of meiosis (GO:0040020)4.24477386
30kinetochore organization (GO:0051383)4.24127993
31DNA methylation or demethylation (GO:0044728)4.24125240
32gene silencing (GO:0016458)4.21219869
33heterochromatin organization (GO:0070828)4.16490196
34DNA strand elongation involved in DNA replication (GO:0006271)4.06893921
35meiotic cell cycle (GO:0051321)4.05869855
36DNA replication-dependent nucleosome assembly (GO:0006335)4.03232096
37DNA replication-dependent nucleosome organization (GO:0034723)4.03232096
38mitotic metaphase plate congression (GO:0007080)4.01231684
39DNA replication checkpoint (GO:0000076)4.01179010
40kinetochore assembly (GO:0051382)3.99698834
41metaphase plate congression (GO:0051310)3.96465791
42telomere maintenance via semi-conservative replication (GO:0032201)3.95671225
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.92150766
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.92150766
45DNA strand elongation (GO:0022616)3.88888928
46sister chromatid segregation (GO:0000819)3.84191096
47regulation of histone H3-K9 methylation (GO:0051570)3.79257252
48monoubiquitinated protein deubiquitination (GO:0035520)3.78612007
49mitotic sister chromatid cohesion (GO:0007064)3.78309129
50resolution of meiotic recombination intermediates (GO:0000712)3.76511573
51positive regulation of translational initiation (GO:0045948)3.74466540
52pore complex assembly (GO:0046931)3.74166538
53chromatin remodeling at centromere (GO:0031055)3.72612683
54protein localization to kinetochore (GO:0034501)3.67491835
55DNA unwinding involved in DNA replication (GO:0006268)3.64444645
56synapsis (GO:0007129)3.62672861
57inner cell mass cell proliferation (GO:0001833)3.59571024
58mitotic spindle assembly checkpoint (GO:0007094)3.56896350
59spindle checkpoint (GO:0031577)3.55288187
60spindle assembly checkpoint (GO:0071173)3.54637507
61protein K6-linked ubiquitination (GO:0085020)3.53772222
62DNA modification (GO:0006304)3.52851230
63regulation of double-strand break repair via homologous recombination (GO:0010569)3.52649442
64DNA replication initiation (GO:0006270)3.52044939
65mitotic nuclear envelope disassembly (GO:0007077)3.52035941
66negative regulation of chromosome segregation (GO:0051985)3.50645934
67mitotic spindle checkpoint (GO:0071174)3.49772800
68regulation of chromosome segregation (GO:0051983)3.49327088
69DNA replication-independent nucleosome organization (GO:0034724)3.46693169
70DNA replication-independent nucleosome assembly (GO:0006336)3.46693169
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.46543955
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46543955
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46543955
74negative regulation of sister chromatid segregation (GO:0033046)3.46543955
75DNA double-strand break processing (GO:0000729)3.46364454
76DNA ligation (GO:0006266)3.45844877
77regulation of DNA endoreduplication (GO:0032875)3.45603591
78protein localization to chromosome (GO:0034502)3.45272925
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.43963093
80histone exchange (GO:0043486)3.43432069
81positive regulation of male gonad development (GO:2000020)3.42281664
82regulation of meiotic cell cycle (GO:0051445)3.41003825
83replication fork processing (GO:0031297)3.39969409
84sex differentiation (GO:0007548)3.39924540
85mitotic recombination (GO:0006312)3.39320360
86regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38882405
87telomere maintenance via recombination (GO:0000722)3.38736453
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.37672659
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.37062228
90protein localization to chromosome, centromeric region (GO:0071459)3.36711027
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35735742
92regulation of sister chromatid segregation (GO:0033045)3.34417725
93regulation of mitotic sister chromatid separation (GO:0010965)3.34417725
94regulation of mitotic sister chromatid segregation (GO:0033047)3.34417725
95nuclear envelope disassembly (GO:0051081)3.34222803
96membrane disassembly (GO:0030397)3.34222803
97negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.31914194
98nucleotide-excision repair, DNA gap filling (GO:0006297)3.30606861
99negative regulation of meiotic cell cycle (GO:0051447)3.30583260
100chromosome segregation (GO:0007059)3.26920557
101negative regulation of nuclear division (GO:0051784)3.26851894
102chromosome organization (GO:0051276)3.24336454
103mitotic sister chromatid segregation (GO:0000070)3.24095398
104double-strand break repair via nonhomologous end joining (GO:0006303)3.23663635
105non-recombinational repair (GO:0000726)3.23663635
106regulation of double-strand break repair (GO:2000779)3.23296101
107establishment of integrated proviral latency (GO:0075713)3.23149290
108CENP-A containing nucleosome assembly (GO:0034080)3.22953420
109histone H2A acetylation (GO:0043968)3.19346092
110proteasome assembly (GO:0043248)3.16766843
111histone H3-K9 methylation (GO:0051567)3.15715425
112histone H4-K12 acetylation (GO:0043983)3.15708415
113chromatin assembly or disassembly (GO:0006333)3.14450468
114purine nucleobase biosynthetic process (GO:0009113)3.14273618
115regulation of centriole replication (GO:0046599)3.14268164
116regulation of sister chromatid cohesion (GO:0007063)3.13898171
117DNA packaging (GO:0006323)3.13592328
118positive regulation of mitotic sister chromatid separation (GO:1901970)3.12506640
119positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12506640
120positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12506640
121DNA topological change (GO:0006265)3.06189766
122nucleobase biosynthetic process (GO:0046112)3.01423209
123DNA damage response, detection of DNA damage (GO:0042769)2.96189215
124DNA catabolic process, exonucleolytic (GO:0000738)2.95000683
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92880671
126IMP biosynthetic process (GO:0006188)2.91424365
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.91319262
128negative regulation of DNA recombination (GO:0045910)2.90850026
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90157004
130regulation of mitotic spindle checkpoint (GO:1903504)2.90157004
131mismatch repair (GO:0006298)2.89147940
132telomere maintenance via telomere lengthening (GO:0010833)2.88434350
133ribosome assembly (GO:0042255)2.87185482
134ATP-dependent chromatin remodeling (GO:0043044)2.86142133
135formation of translation preinitiation complex (GO:0001731)2.84159705
136DNA strand renaturation (GO:0000733)2.83514239
137isotype switching (GO:0045190)2.76179631
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76179631
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76179631
140piRNA metabolic process (GO:0034587)12.6051625
141DNA methylation involved in gamete generation (GO:0043046)10.0723071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.68371847
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.65477867
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.25599050
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.98475372
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.51735308
6AR_21909140_ChIP-Seq_LNCAP_Human3.35481963
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.03522440
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.93403176
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.91563187
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.88552055
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.78809095
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57375562
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39372579
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34940343
15MYCN_18555785_ChIP-Seq_MESCs_Mouse2.33477380
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22291140
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15843350
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15820312
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15820312
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15820312
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.11389735
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.00742985
23E2F7_22180533_ChIP-Seq_HELA_Human10.0694708
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97303651
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95544700
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94557958
27ZNF274_21170338_ChIP-Seq_K562_Hela1.92005557
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85526487
29IGF1R_20145208_ChIP-Seq_DFB_Human1.83193099
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79335727
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78645077
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68660141
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68226643
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64213832
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64112693
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60815106
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56672569
38KDM5A_27292631_Chip-Seq_BREAST_Human1.52273626
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.51245303
40VDR_22108803_ChIP-Seq_LS180_Human1.50799138
41XRN2_22483619_ChIP-Seq_HELA_Human1.50118860
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47188093
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.45350864
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42026926
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41676258
46* RNF2_27304074_Chip-Seq_NSC_Mouse1.40802527
47RUNX1_26923725_Chip-Seq_HPCs_Mouse1.38908058
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38139887
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37516438
50* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37487130
51* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36336352
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.35553304
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29960976
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27207903
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26049534
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25627953
57VDR_23849224_ChIP-Seq_CD4+_Human1.25402839
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.25298838
59MYC_18940864_ChIP-ChIP_HL60_Human1.24760474
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.24272650
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24264397
62GABP_19822575_ChIP-Seq_HepG2_Human1.23756770
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.23462164
64DCP1A_22483619_ChIP-Seq_HELA_Human1.19484030
65IRF1_19129219_ChIP-ChIP_H3396_Human1.16548016
66CIITA_25753668_ChIP-Seq_RAJI_Human1.15775928
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.15155128
68TAF15_26573619_Chip-Seq_HEK293_Human1.14919237
69FOXP3_21729870_ChIP-Seq_TREG_Human1.13937698
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13836826
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12086496
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10389166
73TTF2_22483619_ChIP-Seq_HELA_Human1.10165073
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07739852
75FUS_26573619_Chip-Seq_HEK293_Human1.06245434
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04168415
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02054015
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.01135972
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00203481
80THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97178960
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96978467
82* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96857940
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95877122
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94999912
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93733405
86PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92356389
87NANOG_21062744_ChIP-ChIP_HESCs_Human0.92216755
88EWS_26573619_Chip-Seq_HEK293_Human0.92044541
89STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91759425
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91110481
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90557530
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88776635
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88375193
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87974729
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87771183
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87058480
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85703479
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.85243156
99TP53_22573176_ChIP-Seq_HFKS_Human0.84283534
100TFEB_21752829_ChIP-Seq_HELA_Human0.83773698
101P300_19829295_ChIP-Seq_ESCs_Human0.83246315
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82474953
103ELK1_19687146_ChIP-ChIP_HELA_Human0.81833959
104* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81804404
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81348420
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81028780
107* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80766680
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.80240529
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.80092575
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80059541
111CHD1_26751641_Chip-Seq_LNCaP_Human0.79597309
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77783969
113NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77651486
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77626157
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75536778
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75226270
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75137925
118* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74826495
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74312283
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74298699
121MYC_22102868_ChIP-Seq_BL_Human0.73211517
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71104039
123TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70400862
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70375719
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70204296
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69903102
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68629644
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.68249841
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67265489
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.67066695
131SOX9_26525672_Chip-Seq_HEART_Mouse0.66808184
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.65886992
133ELK4_26923725_Chip-Seq_MESODERM_Mouse0.64920023
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63844065
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.61772147
136REST_19997604_ChIP-ChIP_NEURONS_Mouse0.61625948
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.61604550
138SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.61440000
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.58382432
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.57793578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.46291332
2MP0008995_early_reproductive_senescence4.52922221
3MP0010094_abnormal_chromosome_stability4.16432051
4MP0002210_abnormal_sex_determination3.91686682
5MP0008057_abnormal_DNA_replication3.51194023
6MP0001929_abnormal_gametogenesis3.34738980
7MP0003111_abnormal_nucleus_morphology3.23411758
8MP0008058_abnormal_DNA_repair3.23261655
9MP0003786_premature_aging3.16606954
10MP0001145_abnormal_male_reproductive3.11805013
11MP0003123_paternal_imprinting3.10912503
12MP0003693_abnormal_embryo_hatching3.06019319
13MP0000653_abnormal_sex_gland2.94924075
14MP0003077_abnormal_cell_cycle2.89179377
15MP0004957_abnormal_blastocyst_morpholog2.74153455
16MP0003698_abnormal_male_reproductive2.49347882
17MP0003121_genomic_imprinting2.29838104
18MP0008007_abnormal_cellular_replicative2.23099490
19MP0009697_abnormal_copulation1.95569668
20MP0003787_abnormal_imprinting1.91641650
21MP0001119_abnormal_female_reproductive1.88973083
22MP0001730_embryonic_growth_arrest1.86689442
23MP0008932_abnormal_embryonic_tissue1.70897072
24MP0001529_abnormal_vocalization1.67935789
25MP0000350_abnormal_cell_proliferation1.66106820
26MP0004147_increased_porphyrin_level1.63991881
27MP0002161_abnormal_fertility/fecundity1.63098563
28MP0010307_abnormal_tumor_latency1.61757028
29MP0003136_yellow_coat_color1.57168604
30MP0002234_abnormal_pharynx_morphology1.53762378
31MP0002938_white_spotting1.51380913
32MP0003890_abnormal_embryonic-extraembry1.50013861
33MP0008789_abnormal_olfactory_epithelium1.48121777
34MP0003718_maternal_effect1.47293859
35MP0003699_abnormal_female_reproductive1.44523095
36MP0002085_abnormal_embryonic_tissue1.37695456
37MP0005451_abnormal_body_composition1.36236460
38MP0002084_abnormal_developmental_patter1.36041174
39MP0006072_abnormal_retinal_apoptosis1.34427594
40MP0001672_abnormal_embryogenesis/_devel1.31374645
41MP0005380_embryogenesis_phenotype1.31374645
42MP0005076_abnormal_cell_differentiation1.29140523
43MP0001697_abnormal_embryo_size1.28827842
44MP0003315_abnormal_perineum_morphology1.27441294
45MP0010352_gastrointestinal_tract_polyps1.27282582
46MP0002102_abnormal_ear_morphology1.26522575
47MP0006035_abnormal_mitochondrial_morpho1.26055491
48MP0001188_hyperpigmentation1.25992447
49MP0004808_abnormal_hematopoietic_stem1.25692962
50MP0005394_taste/olfaction_phenotype1.25152916
51MP0005499_abnormal_olfactory_system1.25152916
52MP0003880_abnormal_central_pattern1.21638618
53MP0000049_abnormal_middle_ear1.19074921
54MP0003937_abnormal_limbs/digits/tail_de1.18014451
55MP0003984_embryonic_growth_retardation1.16179581
56MP0002822_catalepsy1.15842610
57MP0000647_abnormal_sebaceous_gland1.14538246
58MP0002160_abnormal_reproductive_system1.14350678
59MP0004133_heterotaxia1.13058191
60MP0004197_abnormal_fetal_growth/weight/1.11781330
61MP0000631_abnormal_neuroendocrine_gland1.11301454
62MP0001286_abnormal_eye_development1.11115939
63MP0002088_abnormal_embryonic_growth/wei1.10633408
64MP0005377_hearing/vestibular/ear_phenot1.04006192
65MP0003878_abnormal_ear_physiology1.04006192
66MP0002086_abnormal_extraembryonic_tissu1.03897942
67MP0001915_intracranial_hemorrhage1.01887192
68MP0002080_prenatal_lethality0.98259235
69MP0002653_abnormal_ependyma_morphology0.97025838
70MP0000313_abnormal_cell_death0.95652887
71MP0006276_abnormal_autonomic_nervous0.92895395
72MP0005647_abnormal_sex_gland0.92778720
73MP0009672_abnormal_birth_weight0.90915107
74MP0005187_abnormal_penis_morphology0.90707302
75MP0002751_abnormal_autonomic_nervous0.89899183
76MP0002396_abnormal_hematopoietic_system0.89606939
77MP0003646_muscle_fatigue0.89568405
78MP0003936_abnormal_reproductive_system0.88855909
79MP0002019_abnormal_tumor_incidence0.88806816
80MP0005253_abnormal_eye_physiology0.87313797
81MP0000569_abnormal_digit_pigmentation0.85906689
82MP0003122_maternal_imprinting0.84342355
83MP0003943_abnormal_hepatobiliary_system0.83510850
84MP0005410_abnormal_fertilization0.81839004
85MP0005391_vision/eye_phenotype0.80922863
86MP0002111_abnormal_tail_morphology0.80557721
87MP0000427_abnormal_hair_cycle0.79058491
88MP0003385_abnormal_body_wall0.76577645
89MP0006292_abnormal_olfactory_placode0.76470917
90MP0005389_reproductive_system_phenotype0.75647627
91MP0003567_abnormal_fetal_cardiomyocyte0.74912872
92MP0003283_abnormal_digestive_organ0.74805185
93MP0005670_abnormal_white_adipose0.71746017
94MP0002009_preneoplasia0.71729066
95MP0005645_abnormal_hypothalamus_physiol0.71266879
96MP0005623_abnormal_meninges_morphology0.70725878
97MP0000358_abnormal_cell_content/0.70346210
98MP0010030_abnormal_orbit_morphology0.70188075
99MP0003938_abnormal_ear_development0.69969929
100MP0000778_abnormal_nervous_system0.67635157
101MP0001984_abnormal_olfaction0.66879967
102MP0004185_abnormal_adipocyte_glucose0.66605818
103MP0006036_abnormal_mitochondrial_physio0.66422781
104MP0003861_abnormal_nervous_system0.64737899
105MP0000432_abnormal_head_morphology0.64649299
106MP0003705_abnormal_hypodermis_morpholog0.64603704
107MP0000537_abnormal_urethra_morphology0.63660707
108MP0009703_decreased_birth_body0.63576183
109MP0003115_abnormal_respiratory_system0.63532180
110MP0001293_anophthalmia0.63487326
111MP0003119_abnormal_digestive_system0.63380365
112MP0008961_abnormal_basal_metabolism0.62794921
113MP0002249_abnormal_larynx_morphology0.62510508
114MP0002163_abnormal_gland_morphology0.62213379
115MP0003755_abnormal_palate_morphology0.61309382
116MP0005395_other_phenotype0.61186523
117MP0001764_abnormal_homeostasis0.60974865
118MP0000383_abnormal_hair_follicle0.59636721
119MP0005408_hypopigmentation0.59188254
120MP0005621_abnormal_cell_physiology0.58943881
121MP0003221_abnormal_cardiomyocyte_apopto0.58691741
122MP0003935_abnormal_craniofacial_develop0.58481515
123MP0002697_abnormal_eye_size0.56750822
124MP0000428_abnormal_craniofacial_morphol0.56073332
125MP0003941_abnormal_skin_development0.55553396
126MP0000490_abnormal_crypts_of0.55222748
127MP0001545_abnormal_hematopoietic_system0.54323820
128MP0005397_hematopoietic_system_phenotyp0.54323820
129MP0002233_abnormal_nose_morphology0.53713094
130MP0001849_ear_inflammation0.53083383
131MP0010678_abnormal_skin_adnexa0.52326713
132MP0004233_abnormal_muscle_weight0.51282392
133MP0005384_cellular_phenotype0.51097526
134MP0002092_abnormal_eye_morphology0.48807734
135MP0002114_abnormal_axial_skeleton0.45598873
136MP0010234_abnormal_vibrissa_follicle0.45088005
137MP0002116_abnormal_craniofacial_bone0.43507120
138MP0002925_abnormal_cardiovascular_devel0.43236451
139MP0009278_abnormal_bone_marrow0.41988689

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)7.67066245
2Abnormal spermatogenesis (HP:0008669)6.71845146
3Chromsome breakage (HP:0040012)5.53899726
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.14098939
5Papillary thyroid carcinoma (HP:0002895)4.34569634
6Gonadotropin excess (HP:0000837)4.17332986
7Facial hemangioma (HP:0000329)4.02977181
8Abnormality of the lower motor neuron (HP:0002366)3.47013857
9Medulloblastoma (HP:0002885)3.41867100
1011 pairs of ribs (HP:0000878)3.40976801
11Male infertility (HP:0003251)3.36556386
12Abnormality of chromosome stability (HP:0003220)3.31832550
13Abnormality of the labia minora (HP:0012880)3.28046257
14Abnormality of the fingertips (HP:0001211)3.03266990
15Ectopic kidney (HP:0000086)3.02729871
16Meckel diverticulum (HP:0002245)2.96204491
17Capillary hemangiomas (HP:0005306)2.89898241
18Rhabdomyosarcoma (HP:0002859)2.78900816
19Shawl scrotum (HP:0000049)2.78774273
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.77138428
21Abnormality of the ileum (HP:0001549)2.76176188
22Ankle contracture (HP:0006466)2.76016201
23Thyroid carcinoma (HP:0002890)2.75764802
24Volvulus (HP:0002580)2.73594181
25Ependymoma (HP:0002888)2.70230017
26Carpal bone hypoplasia (HP:0001498)2.64085001
27Reticulocytopenia (HP:0001896)2.64062070
28Supernumerary spleens (HP:0009799)2.63005712
29Selective tooth agenesis (HP:0001592)2.62248302
30Cortical dysplasia (HP:0002539)2.60713318
31Impulsivity (HP:0100710)2.57946568
32Patellar aplasia (HP:0006443)2.57574489
33Colon cancer (HP:0003003)2.54082049
34Abnormality of the preputium (HP:0100587)2.52100211
35Triphalangeal thumb (HP:0001199)2.47648916
36Sandal gap (HP:0001852)2.44797429
37Absent thumb (HP:0009777)2.43893776
38Neoplasm of striated muscle (HP:0009728)2.41805347
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41259232
40Short 4th metacarpal (HP:0010044)2.41259232
41Astrocytoma (HP:0009592)2.38966129
42Abnormality of the astrocytes (HP:0100707)2.38966129
43Increased nuchal translucency (HP:0010880)2.37290401
44Abnormality of cochlea (HP:0000375)2.36614566
45Nephroblastoma (Wilms tumor) (HP:0002667)2.36614430
46Absent radius (HP:0003974)2.36443798
47Short thumb (HP:0009778)2.36271497
48Small intestinal stenosis (HP:0012848)2.35469137
49Duodenal stenosis (HP:0100867)2.35469137
50Abnormality of the carotid arteries (HP:0005344)2.34359050
51Metaphyseal cupping (HP:0003021)2.32528982
52Aplasia/Hypoplasia of the patella (HP:0006498)2.32229606
53Abnormality of chromosome segregation (HP:0002916)2.31706091
54Oligodactyly (HP:0012165)2.29811897
55Neoplasm of the oral cavity (HP:0100649)2.29471327
56Male pseudohermaphroditism (HP:0000037)2.28313880
57Abnormality of the renal collecting system (HP:0004742)2.27102764
58Long eyelashes (HP:0000527)2.26057885
59Aplasia involving forearm bones (HP:0009822)2.21495152
60Absent forearm bone (HP:0003953)2.21495152
61Intestinal atresia (HP:0011100)2.19789087
62Birth length less than 3rd percentile (HP:0003561)2.19033070
63Truncal obesity (HP:0001956)2.18361532
64Abnormal lung lobation (HP:0002101)2.17208696
65Embryonal renal neoplasm (HP:0011794)2.16429746
66Cafe-au-lait spot (HP:0000957)2.16033686
67Missing ribs (HP:0000921)2.15246292
68Shoulder girdle muscle weakness (HP:0003547)2.13592495
69Medial flaring of the eyebrow (HP:0010747)2.11677542
70Heterotopia (HP:0002282)2.10217113
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09921008
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.09087561
73Breast hypoplasia (HP:0003187)2.08731147
74Prominent nose (HP:0000448)2.08593423
75Abnormality of the phalanges of the hallux (HP:0010057)2.05534761
76Glioma (HP:0009733)2.04994050
77Increased hepatocellular lipid droplets (HP:0006565)2.02067521
78Fibular hypoplasia (HP:0003038)2.01218585
79Premature ovarian failure (HP:0008209)1.99199898
80Duplicated collecting system (HP:0000081)1.98850671
81Proximal placement of thumb (HP:0009623)1.98747864
82Methylmalonic acidemia (HP:0002912)1.98017455
83Pancreatic fibrosis (HP:0100732)1.97282953
84Amyotrophic lateral sclerosis (HP:0007354)1.95200952
85Broad palm (HP:0001169)1.94761565
86Horseshoe kidney (HP:0000085)1.94472247
87Myelodysplasia (HP:0002863)1.93736688
88Pelvic girdle muscle weakness (HP:0003749)1.93716272
89Preaxial hand polydactyly (HP:0001177)1.93348316
90Microvesicular hepatic steatosis (HP:0001414)1.92852607
91Sloping forehead (HP:0000340)1.92760469
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91696211
93Cerebral edema (HP:0002181)1.91284317
94Nephronophthisis (HP:0000090)1.90222461
95Deviation of the thumb (HP:0009603)1.89387489
96Homocystinuria (HP:0002156)1.88436174
97Abnormality of homocysteine metabolism (HP:0010919)1.88436174
98Pancreatic cysts (HP:0001737)1.87660660
99Basal cell carcinoma (HP:0002671)1.87259731
100Acute necrotizing encephalopathy (HP:0006965)1.86711179
101Acute encephalopathy (HP:0006846)1.85751747
102Neoplasm of the colon (HP:0100273)1.85469535
103Primary amenorrhea (HP:0000786)1.85448132
104Clubbing of toes (HP:0100760)1.85372000
105Oligodactyly (hands) (HP:0001180)1.85355115
106Upper motor neuron abnormality (HP:0002127)1.83049858
107Lipid accumulation in hepatocytes (HP:0006561)1.82985654
108Microglossia (HP:0000171)1.82138618
109Wrist flexion contracture (HP:0001239)1.81131678
110Hyperglycinemia (HP:0002154)1.80528742
111Short tibia (HP:0005736)1.80379775
112Abnormality of the duodenum (HP:0002246)1.79948094
113Gonadal dysgenesis (HP:0000133)1.79845050
114Abnormality of DNA repair (HP:0003254)1.79098288
115Urethral obstruction (HP:0000796)1.78984318
116Abnormal number of incisors (HP:0011064)1.78723977
117Abnormality of the aortic arch (HP:0012303)1.78312329
118Congenital primary aphakia (HP:0007707)1.78046200
119Renovascular hypertension (HP:0100817)1.76300979
120Tubulointerstitial nephritis (HP:0001970)1.76145432
121Supernumerary ribs (HP:0005815)1.74865807
122Abnormal mitochondria in muscle tissue (HP:0008316)1.74760712
123Low anterior hairline (HP:0000294)1.73882196
124Bilateral microphthalmos (HP:0007633)1.73857347
125Relative macrocephaly (HP:0004482)1.73606669
126Blepharitis (HP:0000498)1.72978999
127Molar tooth sign on MRI (HP:0002419)1.72819610
128Abnormality of midbrain morphology (HP:0002418)1.72819610
129Acute myeloid leukemia (HP:0004808)1.72735698
130Abnormality of methionine metabolism (HP:0010901)1.72224395
131Hypoplastic iliac wings (HP:0002866)1.71370721
132Morphological abnormality of the inner ear (HP:0011390)1.71240465
133Facial cleft (HP:0002006)1.70309760
134Increased CSF lactate (HP:0002490)1.70033342
135Gastrointestinal atresia (HP:0002589)1.69518944
136Sclerocornea (HP:0000647)1.69434556
137Bifid tongue (HP:0010297)1.69320946
138True hermaphroditism (HP:0010459)1.68526209
139Poor coordination (HP:0002370)1.68169577
140Astigmatism (HP:0000483)1.67290804
141Nephrogenic diabetes insipidus (HP:0009806)1.64836461
142Abnormality of alanine metabolism (HP:0010916)1.63021159
143Hyperalaninemia (HP:0003348)1.63021159
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63021159
145Postaxial foot polydactyly (HP:0001830)1.62884468
146Gait imbalance (HP:0002141)1.62531950
147Abnormality of the pons (HP:0007361)1.61176892
148Embryonal neoplasm (HP:0002898)1.58592709
149Rectovaginal fistula (HP:0000143)1.58322991
150Rectal fistula (HP:0100590)1.58322991
151Genital tract atresia (HP:0001827)1.57855514
152Vaginal atresia (HP:0000148)1.55330738
153Aganglionic megacolon (HP:0002251)1.54016306
154Dandy-Walker malformation (HP:0001305)1.52970241
155Multicystic kidney dysplasia (HP:0000003)1.52937031
156Drooling (HP:0002307)1.52882369
157Abnormality of serum amino acid levels (HP:0003112)1.52607702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.69829753
2CDC75.66378867
3ACVR1B5.50208079
4MKNK23.54964881
5BCKDK3.14036888
6PNCK3.09827473
7TSSK62.79644680
8NEK22.68059282
9WEE12.63253188
10TTK2.52250465
11PLK42.43521616
12ZAK2.42178343
13MKNK12.26501347
14STK38L2.25847141
15BRD42.08605489
16NUAK12.05011731
17TRIM282.01521881
18PLK12.01322051
19EIF2AK31.99787027
20MAP3K61.85229045
21BRSK21.78502281
22MAP3K41.76920920
23LATS11.71646878
24PRKD31.66189652
25CHEK21.65675571
26ATR1.63310672
27STK31.62171114
28CHEK11.59891884
29CDK71.51634418
30TAF11.46379314
31EEF2K1.44158433
32CDK91.43688009
33VRK21.40879298
34ATM1.39739726
35SRPK11.37766690
36EIF2AK11.36523547
37MELK1.33087033
38CDK191.28366866
39STK161.25816676
40CDK81.22485155
41LATS21.21934652
42BRSK11.20674922
43TYRO31.19881674
44AURKB1.18216907
45MAP4K21.18177949
46STK241.12467663
47CDK41.10548939
48PDK41.07817401
49PDK31.07817401
50BUB11.02423426
51PLK30.96628219
52DYRK30.93344942
53SCYL20.92164567
54* CDK20.88956746
55RPS6KA40.88813446
56KSR10.88527411
57CAMK1D0.87851644
58DYRK20.85496426
59NME10.84034066
60NEK10.83366114
61* CDK10.79955728
62ERBB30.79290794
63MTOR0.79124624
64TNIK0.78612562
65WNK40.77007615
66FRK0.75470512
67FLT30.74518281
68EIF2AK20.72323953
69ERBB40.71540862
70TGFBR10.71174642
71STK40.70393815
72RPS6KB20.70051720
73PKN20.69595498
74KSR20.69304690
75BRAF0.68451503
76MET0.67166865
77CSNK1G30.66431528
78PBK0.64588530
79PLK20.63962895
80BMPR1B0.62504675
81AURKA0.61517998
82CSNK1G20.60129617
83RIPK10.59552510
84ICK0.59351965
85RET0.59020542
86TAOK10.56754668
87VRK10.55838627
88EPHA40.53099147
89MAP3K100.52756275
90CSNK2A10.52555936
91GRK10.52333187
92INSRR0.52332299
93MAP2K70.51616856
94MAP3K90.51087861
95MAPKAPK30.50897260
96CASK0.50495869
97PRKDC0.47027706
98CSNK1D0.46973692
99RPS6KA50.46198776
100MAP2K40.45915602
101FGFR10.45356928
102OXSR10.45140171
103ADRBK20.44894821
104MAPK140.44443148
105* GSK3B0.44386817
106MUSK0.43426330
107RAF10.42111611
108MAP3K80.41759583
109MINK10.41130524
110STK100.41113649
111WNK30.40800328
112CSNK1E0.40742160
113PRKCG0.40511184
114MAPK110.36619031
115PASK0.36265306
116CSNK1G10.35812058
117CSNK1A1L0.35767665
118CHUK0.34404544
119CDK30.33812939
120WNK10.33373219
121PINK10.33224363
122CSNK2A20.33162336
123CDC42BPA0.32781971
124CLK10.32420868
125ALK0.32277611
126AKT10.31845552
127MAPKAPK50.31581100
128MAPK130.29732708
129MAPK100.29389986
130MAPK10.29256874
131DYRK1A0.29219621
132MARK30.28742935
133CCNB10.28569559
134RPS6KB10.26788914
135PDK20.24131725
136NLK0.22712625
137PDGFRB0.21873303
138CAMK1G0.21746298
139BCR0.21648749

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.61447830
2Basal transcription factors_Homo sapiens_hsa030224.53968252
3Cell cycle_Homo sapiens_hsa041103.74058837
4Mismatch repair_Homo sapiens_hsa034303.65257723
5DNA replication_Homo sapiens_hsa030303.63574683
6Homologous recombination_Homo sapiens_hsa034403.52838900
7RNA transport_Homo sapiens_hsa030133.32047317
8Fanconi anemia pathway_Homo sapiens_hsa034603.01894662
9mRNA surveillance pathway_Homo sapiens_hsa030152.74690444
10RNA polymerase_Homo sapiens_hsa030202.73526081
11Nucleotide excision repair_Homo sapiens_hsa034202.70352388
12Spliceosome_Homo sapiens_hsa030402.58322773
13RNA degradation_Homo sapiens_hsa030182.58146080
14Base excision repair_Homo sapiens_hsa034102.41108193
15Non-homologous end-joining_Homo sapiens_hsa034502.37030832
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.05257762
17Oocyte meiosis_Homo sapiens_hsa041142.00458975
18Ribosome_Homo sapiens_hsa030101.95991119
19Propanoate metabolism_Homo sapiens_hsa006401.87295218
20Protein export_Homo sapiens_hsa030601.84144043
21p53 signaling pathway_Homo sapiens_hsa041151.79874145
22One carbon pool by folate_Homo sapiens_hsa006701.70852520
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66045528
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59946066
25Dorso-ventral axis formation_Homo sapiens_hsa043201.58954468
26Selenocompound metabolism_Homo sapiens_hsa004501.51455251
27Lysine degradation_Homo sapiens_hsa003101.50125127
28Steroid biosynthesis_Homo sapiens_hsa001001.49403912
29TGF-beta signaling pathway_Homo sapiens_hsa043501.45567053
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43992560
31Parkinsons disease_Homo sapiens_hsa050121.43332826
32Pyrimidine metabolism_Homo sapiens_hsa002401.42845972
33Herpes simplex infection_Homo sapiens_hsa051681.39905537
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37678808
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33460998
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31027205
37Oxidative phosphorylation_Homo sapiens_hsa001901.26633911
38Pyruvate metabolism_Homo sapiens_hsa006201.25559000
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23938573
40Thyroid cancer_Homo sapiens_hsa052161.23126139
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19834746
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14817395
43MicroRNAs in cancer_Homo sapiens_hsa052061.12239155
44Fatty acid elongation_Homo sapiens_hsa000621.12133894
45Epstein-Barr virus infection_Homo sapiens_hsa051691.06322167
46Sulfur relay system_Homo sapiens_hsa041221.04830577
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02898947
48Adherens junction_Homo sapiens_hsa045200.97186630
49HTLV-I infection_Homo sapiens_hsa051660.97028793
50Folate biosynthesis_Homo sapiens_hsa007900.96567024
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96041352
52Purine metabolism_Homo sapiens_hsa002300.92119189
53Proteasome_Homo sapiens_hsa030500.91020166
54Notch signaling pathway_Homo sapiens_hsa043300.88817917
55Butanoate metabolism_Homo sapiens_hsa006500.88790447
56Small cell lung cancer_Homo sapiens_hsa052220.88737647
57Pancreatic cancer_Homo sapiens_hsa052120.87045384
58Hippo signaling pathway_Homo sapiens_hsa043900.86674313
59Circadian rhythm_Homo sapiens_hsa047100.84254074
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82823076
61Colorectal cancer_Homo sapiens_hsa052100.82102280
62Viral carcinogenesis_Homo sapiens_hsa052030.80132453
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.78603467
64Carbon metabolism_Homo sapiens_hsa012000.73993495
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72716268
66Basal cell carcinoma_Homo sapiens_hsa052170.72460189
67Linoleic acid metabolism_Homo sapiens_hsa005910.72139849
68Ovarian steroidogenesis_Homo sapiens_hsa049130.68669063
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67101888
70Phototransduction_Homo sapiens_hsa047440.64249378
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62869095
72Influenza A_Homo sapiens_hsa051640.61789597
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61603114
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61410719
75Metabolic pathways_Homo sapiens_hsa011000.60843264
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60543917
77Fatty acid metabolism_Homo sapiens_hsa012120.60421048
78Hedgehog signaling pathway_Homo sapiens_hsa043400.59251167
79mTOR signaling pathway_Homo sapiens_hsa041500.57423191
80Peroxisome_Homo sapiens_hsa041460.55897736
81FoxO signaling pathway_Homo sapiens_hsa040680.54929861
82Pathways in cancer_Homo sapiens_hsa052000.51344133
83Alzheimers disease_Homo sapiens_hsa050100.50885497
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50455953
85N-Glycan biosynthesis_Homo sapiens_hsa005100.50361380
86Prostate cancer_Homo sapiens_hsa052150.48511894
87Tight junction_Homo sapiens_hsa045300.47668631
88Wnt signaling pathway_Homo sapiens_hsa043100.46915698
89Olfactory transduction_Homo sapiens_hsa047400.44494994
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.43535842
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.40341536
92ECM-receptor interaction_Homo sapiens_hsa045120.39400818
93Glutathione metabolism_Homo sapiens_hsa004800.38904497
94Nicotine addiction_Homo sapiens_hsa050330.37549917
95Nitrogen metabolism_Homo sapiens_hsa009100.37274582
96Endometrial cancer_Homo sapiens_hsa052130.37101906
97Pentose phosphate pathway_Homo sapiens_hsa000300.36736860
98Systemic lupus erythematosus_Homo sapiens_hsa053220.35996795
99Vitamin B6 metabolism_Homo sapiens_hsa007500.35726103
100Ether lipid metabolism_Homo sapiens_hsa005650.33706869
101Renal cell carcinoma_Homo sapiens_hsa052110.33392672
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33046499
103Non-small cell lung cancer_Homo sapiens_hsa052230.32623951
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31959626
105Prolactin signaling pathway_Homo sapiens_hsa049170.30959155
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28956283
107Hepatitis B_Homo sapiens_hsa051610.28947267
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28516630
109Retinol metabolism_Homo sapiens_hsa008300.28341020
110Cardiac muscle contraction_Homo sapiens_hsa042600.28071449
111Choline metabolism in cancer_Homo sapiens_hsa052310.27568028
112Arginine and proline metabolism_Homo sapiens_hsa003300.26551573
113Antigen processing and presentation_Homo sapiens_hsa046120.26527164
114Regulation of autophagy_Homo sapiens_hsa041400.26016727
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.25574325
116Vitamin digestion and absorption_Homo sapiens_hsa049770.25534647
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24942696
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24490596
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24297784
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.22317964
121beta-Alanine metabolism_Homo sapiens_hsa004100.22247391
122Inositol phosphate metabolism_Homo sapiens_hsa005620.21612274
123Biosynthesis of amino acids_Homo sapiens_hsa012300.21103109
124HIF-1 signaling pathway_Homo sapiens_hsa040660.20950871
125Taste transduction_Homo sapiens_hsa047420.20430413
126Chronic myeloid leukemia_Homo sapiens_hsa052200.19167700
127Focal adhesion_Homo sapiens_hsa045100.18697342
128Proteoglycans in cancer_Homo sapiens_hsa052050.18697000
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18130835
130ErbB signaling pathway_Homo sapiens_hsa040120.17933398
131VEGF signaling pathway_Homo sapiens_hsa043700.17844088
132Glycerolipid metabolism_Homo sapiens_hsa005610.16836339
133Melanoma_Homo sapiens_hsa052180.16063967
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.15188360
135Fatty acid degradation_Homo sapiens_hsa000710.14531719
136Glucagon signaling pathway_Homo sapiens_hsa049220.13348758
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13137415
138Sulfur metabolism_Homo sapiens_hsa009200.12729201
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12363576
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.11764072
141Glioma_Homo sapiens_hsa052140.11698933
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11411479
143Huntingtons disease_Homo sapiens_hsa050160.10789333
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10735359
145Caffeine metabolism_Homo sapiens_hsa002320.10392165
146Alcoholism_Homo sapiens_hsa050340.10160329
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09596876
148Toxoplasmosis_Homo sapiens_hsa051450.08932710
149Ras signaling pathway_Homo sapiens_hsa040140.08804431
150Shigellosis_Homo sapiens_hsa051310.08682733
151Fat digestion and absorption_Homo sapiens_hsa049750.08134546
152AMPK signaling pathway_Homo sapiens_hsa041520.08030067
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.07589201
154Apoptosis_Homo sapiens_hsa042100.07538837
155Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.06840621

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