ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.54495490
2	ribosome assembly (GO:0042255)	4.47584403
3	formation of translation preinitiation complex (GO:0001731)	4.34151797
4	DNA replication checkpoint (GO:0000076)	4.13892770
5	ribosomal small subunit assembly (GO:0000028)	4.11926357
6	mitotic sister chromatid segregation (GO:0000070)	4.11160264
7	homocysteine metabolic process (GO:0050667)	4.05332659
8	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.03519742
9	nuclear pore complex assembly (GO:0051292)	3.94416076
10	proteasome assembly (GO:0043248)	3.85725574
11	mitotic metaphase plate congression (GO:0007080)	3.85214934
12	sister chromatid segregation (GO:0000819)	3.80476201
13	ribosomal large subunit biogenesis (GO:0042273)	3.77301372
14	mitotic chromosome condensation (GO:0007076)	3.76899566
15	ribosome biogenesis (GO:0042254)	3.67290759
16	nuclear pore organization (GO:0006999)	3.66251210
17	regulation of cellular respiration (GO:0043457)	3.64546331
18	oxidative phosphorylation (GO:0006119)	3.62515460
19	regulation of translational fidelity (GO:0006450)	3.61382363
20	ribonucleoprotein complex biogenesis (GO:0022613)	3.55372932
21	tRNA aminoacylation for protein translation (GO:0006418)	3.52187817
22	synapsis (GO:0007129)	3.49682385
23	DNA replication initiation (GO:0006270)	3.47551282
24	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.43135893
25	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.40988208
26	amino acid activation (GO:0043038)	3.40191980
27	tRNA aminoacylation (GO:0043039)	3.40191980
28	regulation of oxidative phosphorylation (GO:0002082)	3.33103297
29	viral transcription (GO:0019083)	3.32053131
30	rRNA modification (GO:0000154)	3.31573064
31	oxaloacetate metabolic process (GO:0006107)	3.29218897
32	ribosomal small subunit biogenesis (GO:0042274)	3.28684625
33	diterpenoid biosynthetic process (GO:0016102)	3.28170960
34	translational termination (GO:0006415)	3.26406759
35	mitotic nuclear envelope disassembly (GO:0007077)	3.25564939
36	tricarboxylic acid cycle (GO:0006099)	3.25254501
37	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.22952791
38	DNA strand elongation involved in DNA replication (GO:0006271)	3.19616219
39	translational initiation (GO:0006413)	3.18584149
40	metaphase plate congression (GO:0051310)	3.18313867
41	rRNA methylation (GO:0031167)	3.17928447
42	folic acid-containing compound biosynthetic process (GO:0009396)	3.15104427
43	transcription from mitochondrial promoter (GO:0006390)	3.08482576
44	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.07942701
45	regulation of mitochondrial translation (GO:0070129)	3.07200092
46	aerobic respiration (GO:0009060)	3.06972459
47	DNA strand elongation (GO:0022616)	3.05137847
48	regulation of chromosome segregation (GO:0051983)	3.04615477
49	protein localization to chromosome, centromeric region (GO:0071459)	3.03439262
50	chromosome segregation (GO:0007059)	3.02358319
51	regulation of mitotic spindle organization (GO:0060236)	3.00960379
52	telomere maintenance via semi-conservative replication (GO:0032201)	3.00416639
53	membrane disassembly (GO:0030397)	2.97050818
54	nuclear envelope disassembly (GO:0051081)	2.97050818
55	CENP-A containing nucleosome assembly (GO:0034080)	2.96377185
56	pteridine-containing compound biosynthetic process (GO:0042559)	2.96074577
57	chromosome condensation (GO:0030261)	2.95587757
58	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.93471928
59	DNA methylation involved in gamete generation (GO:0043046)	2.92304174
60	desmosome organization (GO:0002934)	2.90529803
61	mitochondrial RNA metabolic process (GO:0000959)	2.89082099
62	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.88173151
63	translational elongation (GO:0006414)	2.87404028
64	protein-cofactor linkage (GO:0018065)	2.85587627
65	protein localization to kinetochore (GO:0034501)	2.85527131
66	cotranslational protein targeting to membrane (GO:0006613)	2.85261777
67	protein targeting to ER (GO:0045047)	2.82784170
68	GDP-mannose metabolic process (GO:0019673)	2.82728577
69	DNA unwinding involved in DNA replication (GO:0006268)	2.81185283
70	pore complex assembly (GO:0046931)	2.79256207
71	IMP biosynthetic process (GO:0006188)	2.78552890
72	regulation of spindle organization (GO:0090224)	2.77149786
73	translation (GO:0006412)	2.75096792
74	DNA packaging (GO:0006323)	2.74903846
75	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.74871605
76	regulation of centriole replication (GO:0046599)	2.74830963
77	NADH metabolic process (GO:0006734)	2.73437135
78	cellular component biogenesis (GO:0044085)	2.73183436
79	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.73026092
80	protein localization to endoplasmic reticulum (GO:0070972)	2.72917531
81	gas transport (GO:0015669)	2.72906060
82	resolution of meiotic recombination intermediates (GO:0000712)	2.72718130
83	protein autoprocessing (GO:0016540)	2.71227381
84	L-alpha-amino acid transmembrane transport (GO:1902475)	2.69890464
85	viral life cycle (GO:0019058)	2.69599903
86	terpenoid biosynthetic process (GO:0016114)	2.69574483
87	cellular protein complex disassembly (GO:0043624)	2.68934279
88	rRNA processing (GO:0006364)	2.68792757
89	tetrahydrofolate metabolic process (GO:0046653)	2.68717270
90	purine nucleobase biosynthetic process (GO:0009113)	2.67948122
91	nucleoside diphosphate biosynthetic process (GO:0009133)	2.67921142
92	mitotic spindle checkpoint (GO:0071174)	2.67278369
93	Golgi transport vesicle coating (GO:0048200)	2.66401824
94	COPI coating of Golgi vesicle (GO:0048205)	2.66401824
95	proline biosynthetic process (GO:0006561)	2.65991739
96	chromatin remodeling at centromere (GO:0031055)	2.65091844
97	regulation of RNA export from nucleus (GO:0046831)	2.62905087
98	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.61816841
99	sperm capacitation (GO:0048240)	2.61507158
100	rRNA metabolic process (GO:0016072)	2.61356234

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.74487593
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.07131109
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.81459067
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.74306466
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.57711074
6	ZNF263_19887448_ChIP-Seq_K562_Human	3.56188416
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.33585299
8	AR_21909140_ChIP-Seq_LNCAP_Human	3.12729880
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.09417409
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.08200395
11	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.96611451
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.94785352
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.93705225
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.82012655
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.80506763
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.65932510
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.59584562
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.51930409
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.45516824
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.30460500
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.26500005
22	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.09758706
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.08229868
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.07267292
25	XRN2_22483619_ChIP-Seq_HELA_Human	2.03293621
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.97612153
27	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.88332193
28	TTF2_22483619_ChIP-Seq_HELA_Human	1.86045214
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84258065
30	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.80630000
31	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.79732118
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.74411811
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72122084
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68809932
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.67423074
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.66776997
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.64877826
38	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.63469946
39	NCOR1_26117541_ChIP-Seq_K562_Human	1.58398026
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58384314
41	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.58204542
42	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.56777945
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.55066040
44	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.54478890
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53351687
46	KDM5A_27292631_Chip-Seq_BREAST_Human	1.49125239
47	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.47669033
48	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.46595741
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.43632480
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.43107611
51	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.42125274
52	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.41742915
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.40582727
54	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.36541133
55	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.34588189
56	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.32522877
57	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.27939097
58	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.26507559
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24763202
60	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.23043909
61	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21621610
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.19205171
63	GATA6_25053715_ChIP-Seq_YYC3_Human	1.19046466
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19045504
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14664742
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13545901
67	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.12035954
68	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.11578449
69	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.10368146
70	TFEB_21752829_ChIP-Seq_HELA_Human	1.08863321
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08681122
72	GATA1_19941826_ChIP-Seq_K562_Human	1.07537602
73	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.07145273
74	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.06493383
75	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06239231
76	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.05634746
77	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.00859426
78	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.98042258
79	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.97096336
80	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.97096336
81	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.97096336
82	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.96647825
83	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.96592842
84	ELF5_23300383_ChIP-Seq_T47D_Human	0.94897600
85	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93114736
86	GATA4_25053715_ChIP-Seq_YYC3_Human	0.92225063
87	GATA2_19941826_ChIP-Seq_K562_Human	0.91882905
88	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.91806279
89	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.91556355
90	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.91208929
91	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.89400011
92	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.87497292
93	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.86542723
94	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.84988785
95	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.84754170
96	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.84504927
97	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.84175592
98	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.83119521
99	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.82806774
100	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.82413454

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.87055557
2	MP0004147_increased_porphyrin_level	5.58392761
3	MP0004957_abnormal_blastocyst_morpholog	4.15699992
4	MP0003693_abnormal_embryo_hatching	4.14240152
5	MP0004264_abnormal_extraembryonic_tissu	3.19073141
6	MP0005451_abnormal_body_composition	2.84183684
7	MP0003111_abnormal_nucleus_morphology	2.80500474
8	MP0003718_maternal_effect	2.72878486
9	MP0008058_abnormal_DNA_repair	2.67053170
10	MP0002139_abnormal_hepatobiliary_system	2.63704728
11	MP0010094_abnormal_chromosome_stability	2.55434837
12	MP0002796_impaired_skin_barrier	2.41881875
13	MP0003077_abnormal_cell_cycle	2.22908088
14	MP0009697_abnormal_copulation	2.21698281
15	MP0005408_hypopigmentation	2.19632759
16	MP0010352_gastrointestinal_tract_polyps	2.08908243
17	MP0010234_abnormal_vibrissa_follicle	2.05496361
18	MP0008932_abnormal_embryonic_tissue	1.96639808
19	MP0003186_abnormal_redox_activity	1.96165834
20	MP0008995_early_reproductive_senescence	1.90058928
21	MP0001764_abnormal_homeostasis	1.88924998
22	MP0008057_abnormal_DNA_replication	1.86489384
23	MP0005085_abnormal_gallbladder_physiolo	1.81684755
24	MP0001730_embryonic_growth_arrest	1.77142596
25	MP0006036_abnormal_mitochondrial_physio	1.68643144
26	MP0005636_abnormal_mineral_homeostasis	1.67100584
27	MP0008004_abnormal_stomach_pH	1.64813293
28	MP0005501_abnormal_skin_physiology	1.62262519
29	MP0000678_abnormal_parathyroid_gland	1.60909459
30	MP0000647_abnormal_sebaceous_gland	1.59202103
31	MP0005377_hearing/vestibular/ear_phenot	1.53811136
32	MP0003878_abnormal_ear_physiology	1.53811136
33	MP0006035_abnormal_mitochondrial_morpho	1.52989257
34	MP0003567_abnormal_fetal_cardiomyocyte	1.50489565
35	MP0000372_irregular_coat_pigmentation	1.47761284
36	MP0010307_abnormal_tumor_latency	1.44396678
37	MP0002098_abnormal_vibrissa_morphology	1.41487158
38	MP0001697_abnormal_embryo_size	1.41107745
39	MP0004782_abnormal_surfactant_physiolog	1.38514853
40	MP0002132_abnormal_respiratory_system	1.35774473
41	MP0000490_abnormal_crypts_of	1.33965997
42	MP0000350_abnormal_cell_proliferation	1.33669393
43	MP0005380_embryogenesis_phenotype	1.33545396
44	MP0001672_abnormal_embryogenesis/_devel	1.33545396
45	MP0005365_abnormal_bile_salt	1.33197251
46	MP0002086_abnormal_extraembryonic_tissu	1.32098541
47	MP0003786_premature_aging	1.27712991
48	MP0002080_prenatal_lethality	1.25479984
49	MP0001929_abnormal_gametogenesis	1.21539459
50	MP0005670_abnormal_white_adipose	1.19361930
51	MP0004019_abnormal_vitamin_homeostasis	1.14432050
52	MP0002396_abnormal_hematopoietic_system	1.13838912
53	MP0003984_embryonic_growth_retardation	1.12824136
54	MP0002210_abnormal_sex_determination	1.12217742
55	MP0000358_abnormal_cell_content/	1.09613371
56	MP0002088_abnormal_embryonic_growth/wei	1.08490407
57	MP0008260_abnormal_autophagy	1.05454726
58	MP0000313_abnormal_cell_death	1.01414354
59	MP0000377_abnormal_hair_follicle	0.98719307
60	MP0000477_abnormal_intestine_morphology	0.97731557
61	MP0004043_abnormal_pH_regulation	0.95224754
62	MP0005083_abnormal_biliary_tract	0.94594470
63	MP0009379_abnormal_foot_pigmentation	0.93786264
64	MP0001661_extended_life_span	0.92911440
65	MP0005332_abnormal_amino_acid	0.92591461
66	MP0005410_abnormal_fertilization	0.89697012
67	MP0005058_abnormal_lysosome_morphology	0.89443926
68	MP0001145_abnormal_male_reproductive	0.88749310
69	MP0001727_abnormal_embryo_implantation	0.88143960
70	MP0000653_abnormal_sex_gland	0.85375345
71	MP0002085_abnormal_embryonic_tissue	0.83896462
72	MP0002877_abnormal_melanocyte_morpholog	0.83257525
73	MP0002084_abnormal_developmental_patter	0.82921071
74	MP0008007_abnormal_cellular_replicative	0.82150074
75	MP0005319_abnormal_enzyme/_coenzyme	0.81438703
76	MP0003698_abnormal_male_reproductive	0.80977576
77	MP0001666_abnormal_nutrient_absorption	0.80251329
78	MP0009115_abnormal_fat_cell	0.79041308
79	MP0002269_muscular_atrophy	0.78798578
80	MP0009333_abnormal_splenocyte_physiolog	0.76105619
81	MP0008877_abnormal_DNA_methylation	0.74316232
82	MP0001216_abnormal_epidermal_layer	0.74014593
83	MP0003890_abnormal_embryonic-extraembry	0.73662496
84	MP0008872_abnormal_physiological_respon	0.71944067
85	MP0000609_abnormal_liver_physiology	0.71872148
86	MP0004233_abnormal_muscle_weight	0.70942832
87	MP0000462_abnormal_digestive_system	0.70510752
88	MP0003699_abnormal_female_reproductive	0.70400322
89	MP0001881_abnormal_mammary_gland	0.69587973
90	MP0001765_abnormal_ion_homeostasis	0.69153401
91	MP0002938_white_spotting	0.66903276
92	MP0003937_abnormal_limbs/digits/tail_de	0.66555033
93	MP0008770_decreased_survivor_rate	0.64204843
94	MP0003123_paternal_imprinting	0.63806757
95	MP0002161_abnormal_fertility/fecundity	0.62938460
96	MP0003959_abnormal_lean_body	0.61259770
97	MP0000383_abnormal_hair_follicle	0.60572330
98	MP0002019_abnormal_tumor_incidence	0.59529941
99	MP0001873_stomach_inflammation	0.59462678
100	MP0003950_abnormal_plasma_membrane	0.59388197

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased serum pyruvate (HP:0003542)	4.14989268
2	Ileus (HP:0002595)	4.02529142
3	Abnormality of glycolysis (HP:0004366)	3.87491568
4	Birth length less than 3rd percentile (HP:0003561)	3.48869578
5	Right ventricular cardiomyopathy (HP:0011663)	3.21900857
6	Pallor (HP:0000980)	3.20964155
7	Abnormality of dental color (HP:0011073)	3.14635747
8	Seborrheic dermatitis (HP:0001051)	3.12966860
9	Palpitations (HP:0001962)	3.08131576
10	Truncus arteriosus (HP:0001660)	3.07841732
11	Reticulocytosis (HP:0001923)	3.01089488
12	Macrocytic anemia (HP:0001972)	2.97351493
13	Abnormal hemoglobin (HP:0011902)	2.95683288
14	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.94538758
15	Hyperactive renin-angiotensin system (HP:0000841)	2.92622976
16	Cholecystitis (HP:0001082)	2.89834227
17	Abnormal gallbladder physiology (HP:0012438)	2.89834227
18	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.83545751
19	Paralysis (HP:0003470)	2.82790159
20	Abnormality of reticulocytes (HP:0004312)	2.81953908
21	Ankyloglossia (HP:0010296)	2.80783311
22	Amelogenesis imperfecta (HP:0000705)	2.74473056
23	Microvesicular hepatic steatosis (HP:0001414)	2.69763034
24	Abnormality of cells of the erythroid lineage (HP:0012130)	2.65710513
25	Breech presentation (HP:0001623)	2.64688887
26	Aplastic anemia (HP:0001915)	2.64388659
27	Acanthocytosis (HP:0001927)	2.61686322
28	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.53877335
29	Poikilocytosis (HP:0004447)	2.53805298
30	Chromsome breakage (HP:0040012)	2.50844565
31	Polycythemia (HP:0001901)	2.49698355
32	Premature ovarian failure (HP:0008209)	2.48143015
33	Intrahepatic cholestasis (HP:0001406)	2.47677960
34	Acute encephalopathy (HP:0006846)	2.47531981
35	Renal tubular acidosis (HP:0001947)	2.44762704
36	Reticulocytopenia (HP:0001896)	2.41556573
37	Hypoparathyroidism (HP:0000829)	2.40303980
38	Septate vagina (HP:0001153)	2.39739358
39	Abnormality of homocysteine metabolism (HP:0010919)	2.38336882
40	Homocystinuria (HP:0002156)	2.38336882
41	Abnormality of alanine metabolism (HP:0010916)	2.36557625
42	Hyperalaninemia (HP:0003348)	2.36557625
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.36557625
44	Abnormality of methionine metabolism (HP:0010901)	2.36057387
45	Cerebral hypomyelination (HP:0006808)	2.33094530
46	Proximal tubulopathy (HP:0000114)	2.32890563
47	Increased CSF lactate (HP:0002490)	2.31529750
48	Abnormal mitochondria in muscle tissue (HP:0008316)	2.29002284
49	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.28758066
50	Hyperbilirubinemia (HP:0002904)	2.27417107
51	Tinnitus (HP:0000360)	2.24557932
52	Hyperammonemia (HP:0001987)	2.24403764
53	Acute necrotizing encephalopathy (HP:0006965)	2.23776676
54	Abnormality of renin-angiotensin system (HP:0000847)	2.23462284
55	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21735158
56	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21735158
57	Upper limb muscle weakness (HP:0003484)	2.18326462
58	Increased serum lactate (HP:0002151)	2.17977118
59	Woolly hair (HP:0002224)	2.13583473
60	Metabolic alkalosis (HP:0200114)	2.13535792
61	Cerebral edema (HP:0002181)	2.09056620
62	Alkalosis (HP:0001948)	2.08793803
63	Abnormal lung lobation (HP:0002101)	2.07678886
64	Pili torti (HP:0003777)	2.05651325
65	Hyponatremia (HP:0002902)	2.05560477
66	Lactic acidosis (HP:0003128)	2.04499627
67	Degeneration of anterior horn cells (HP:0002398)	1.99022188
68	Abnormality of the anterior horn cell (HP:0006802)	1.99022188
69	Flat acetabular roof (HP:0003180)	1.98352620
70	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.97546965
71	Male infertility (HP:0003251)	1.96963902
72	Abnormality of magnesium homeostasis (HP:0004921)	1.96164686
73	Hyperthyroidism (HP:0000836)	1.94460879
74	CNS hypomyelination (HP:0003429)	1.91939426
75	Abnormality of pyrimidine metabolism (HP:0004353)	1.90464092
76	Abnormal number of erythroid precursors (HP:0012131)	1.88028043
77	Ureteral duplication (HP:0000073)	1.87763439
78	Megaloblastic anemia (HP:0001889)	1.85301369
79	Secondary amenorrhea (HP:0000869)	1.85234444
80	Abnormality of serum amino acid levels (HP:0003112)	1.84220410
81	Renal tubular dysfunction (HP:0000124)	1.84041241
82	Bilateral sensorineural hearing impairment (HP:0008619)	1.83421941
83	Breast hypoplasia (HP:0003187)	1.82447302
84	Lethargy (HP:0001254)	1.80575664
85	Horseshoe kidney (HP:0000085)	1.80405307
86	Limb hypertonia (HP:0002509)	1.77648646
87	Type I transferrin isoform profile (HP:0003642)	1.77511342
88	Abnormality of cochlea (HP:0000375)	1.75892530
89	Short middle phalanx of the 5th finger (HP:0004220)	1.73327271
90	Acute myeloid leukemia (HP:0004808)	1.73282812
91	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.72333008
92	Hypomagnesemia (HP:0002917)	1.72266083
93	Widely patent fontanelles and sutures (HP:0004492)	1.72056069
94	Increased nuchal translucency (HP:0010880)	1.71905822
95	Tetany (HP:0001281)	1.70815189
96	Abnormal hair laboratory examination (HP:0003328)	1.70460750
97	Abnormally folded helix (HP:0008544)	1.70280811
98	Increased hepatocellular lipid droplets (HP:0006565)	1.69582647
99	Myelodysplasia (HP:0002863)	1.68848438
100	Orthostatic hypotension (HP:0001278)	1.67650676

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	3.89373461
2	EIF2AK1	3.80208169
3	MST4	3.66307170
4	NEK1	3.51695626
5	TTK	3.38517586
6	PDK2	3.15103750
7	NME1	2.81919446
8	PLK4	2.81213488
9	WEE1	2.79887202
10	SRPK1	2.79278756
11	LATS1	2.73309097
12	EIF2AK3	2.44922945
13	MST1R	2.38679603
14	WNK4	2.24324574
15	EPHA2	2.15845313
16	STK3	2.11052144
17	BMPR2	2.04983991
18	NEK2	1.94786602
19	STK39	1.88759150
20	NME2	1.83570287
21	BUB1	1.74359705
22	BRSK2	1.70618057
23	LATS2	1.65498849
24	AKT3	1.54691642
25	CDC7	1.49769194
26	CCNB1	1.48172826
27	KSR2	1.37983954
28	MAP3K2	1.37755421
29	RPS6KB2	1.35781259
30	CLK1	1.33916325
31	MATK	1.29758678
32	ACVR1B	1.25530308
33	RIPK4	1.25522283
34	PLK1	1.24282591
35	MAP3K8	1.22436268
36	SCYL2	1.20271323
37	TESK2	1.15946670
38	PLK3	1.14141891
39	STK38L	1.13478692
40	STK16	1.13045160
41	AURKB	1.08820257
42	BRSK1	1.06829388
43	OXSR1	1.04094549
44	MAP3K12	1.01435074
45	CHEK2	0.99361954
46	STK24	0.92528500
47	ZAK	0.91709250
48	PAK4	0.89471905
49	TSSK6	0.88169074
50	BRAF	0.84706460
51	PRKG2	0.76850844
52	PIK3CA	0.74186415
53	STK4	0.73029741
54	RAF1	0.72595469
55	CHEK1	0.72334184
56	NEK6	0.71481836
57	CDK7	0.69976986
58	BMX	0.68385926
59	PRKCI	0.66734107
60	DYRK3	0.66358145
61	PASK	0.65348192
62	ALK	0.64747245
63	ICK	0.64616277
64	NTRK3	0.63517331
65	STK10	0.61592465
66	RPS6KA4	0.60072340
67	LMTK2	0.59825072
68	ATR	0.59010903
69	MET	0.57944638
70	PAK1	0.57261647
71	MKNK1	0.55102829
72	PIM1	0.53387587
73	YES1	0.52678513
74	CSNK2A2	0.51211742
75	AURKA	0.49651364
76	CDK1	0.48418450
77	CSNK2A1	0.48174426
78	AKT2	0.46564349
79	ILK	0.46194373
80	CDK2	0.41989083
81	EEF2K	0.41687266
82	KSR1	0.41648506
83	EIF2AK2	0.40718554
84	MYLK	0.39643030
85	MAP2K1	0.39066146
86	TNIK	0.38696225
87	ATM	0.36046669
88	PAK2	0.35350191
89	IRAK3	0.33767541
90	CSNK1E	0.31724777
91	PRKAA2	0.29146991
92	CDK4	0.29094051
93	LRRK2	0.28223244
94	PLK2	0.27396132
95	ERBB2	0.24553283
96	ERBB4	0.24543088
97	PHKG2	0.24217375
98	PHKG1	0.24217375
99	RIPK1	0.24212330
100	MARK3	0.22341577

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.38899895
2	Ribosome_Homo sapiens_hsa03010	3.16319328
3	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.07359767
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.90305418
5	Mismatch repair_Homo sapiens_hsa03430	2.57346460
6	DNA replication_Homo sapiens_hsa03030	2.54398498
7	One carbon pool by folate_Homo sapiens_hsa00670	2.25641499
8	Sulfur metabolism_Homo sapiens_hsa00920	2.22801386
9	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.21637407
10	Proteasome_Homo sapiens_hsa03050	2.16972952
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.87697416
12	RNA transport_Homo sapiens_hsa03013	1.85740971
13	Basal transcription factors_Homo sapiens_hsa03022	1.84422740
14	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.74311216
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.73895722
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.72627947
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.67985230
18	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.66178981
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.62149954
20	Spliceosome_Homo sapiens_hsa03040	1.59074311
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.58991427
22	Parkinsons disease_Homo sapiens_hsa05012	1.55119308
23	RNA polymerase_Homo sapiens_hsa03020	1.54017648
24	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.51727964
25	Carbon metabolism_Homo sapiens_hsa01200	1.51142870
26	Cell cycle_Homo sapiens_hsa04110	1.50496142
27	Homologous recombination_Homo sapiens_hsa03440	1.49723134
28	Folate biosynthesis_Homo sapiens_hsa00790	1.48963880
29	Base excision repair_Homo sapiens_hsa03410	1.47272391
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.46113109
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.44604963
32	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.43203036
33	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.42358837
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41144636
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.40930180
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39513701
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.38675663
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.31519416
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.30761173
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.29768701
41	Huntingtons disease_Homo sapiens_hsa05016	1.29556537
42	Mineral absorption_Homo sapiens_hsa04978	1.28270249
43	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.22615033
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19175405
45	Propanoate metabolism_Homo sapiens_hsa00640	1.18715643
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13319034
47	RNA degradation_Homo sapiens_hsa03018	1.08926906
48	Steroid biosynthesis_Homo sapiens_hsa00100	1.06295349
49	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06073569
50	Sulfur relay system_Homo sapiens_hsa04122	0.99428599
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.99228765
52	Glutathione metabolism_Homo sapiens_hsa00480	0.98687990
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.96030415
54	Pentose phosphate pathway_Homo sapiens_hsa00030	0.94492863
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.92729390
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91736495
57	Purine metabolism_Homo sapiens_hsa00230	0.90888532
58	Galactose metabolism_Homo sapiens_hsa00052	0.89635006
59	Protein export_Homo sapiens_hsa03060	0.85631665
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85361183
61	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.81454793
62	Fatty acid elongation_Homo sapiens_hsa00062	0.80586823
63	Retinol metabolism_Homo sapiens_hsa00830	0.80575188
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79052330
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.75876776
66	Vibrio cholerae infection_Homo sapiens_hsa05110	0.75531941
67	Caffeine metabolism_Homo sapiens_hsa00232	0.75174602
68	Metabolic pathways_Homo sapiens_hsa01100	0.74204223
69	Alzheimers disease_Homo sapiens_hsa05010	0.74154637
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73806282
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73569945
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72636398
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.70096522
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68329953
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67338393
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66761534
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.66132580
78	Butanoate metabolism_Homo sapiens_hsa00650	0.64640414
79	Fatty acid degradation_Homo sapiens_hsa00071	0.64190060
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63404464
81	Oocyte meiosis_Homo sapiens_hsa04114	0.61479908
82	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.60174075
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.60111420
84	Thyroid cancer_Homo sapiens_hsa05216	0.59942516
85	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.59733211
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55694247
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54237002
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53762827
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52592725
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.49606206
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49510412
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49029073
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.47825712
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44870318
95	Peroxisome_Homo sapiens_hsa04146	0.41241075
96	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.37958784
97	Bile secretion_Homo sapiens_hsa04976	0.35652728
98	p53 signaling pathway_Homo sapiens_hsa04115	0.32427341
99	Other glycan degradation_Homo sapiens_hsa00511	0.29254763
100	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.28204547

SCML2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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