SCML2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore assembly (GO:0051382)7.63622982
2auditory receptor cell differentiation (GO:0042491)6.96086436
3kinetochore organization (GO:0051383)5.79566090
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.73670966
5regulation of telomere maintenance via telomerase (GO:0032210)5.68999574
6disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.47920913
7killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.47920913
8regulation of prostaglandin secretion (GO:0032306)5.35042890
9sequestering of extracellular ligand from receptor (GO:0035581)5.11924065
10response to interleukin-15 (GO:0070672)4.88579473
11interferon-gamma secretion (GO:0072643)4.86659191
12positive regulation of B cell differentiation (GO:0045579)4.83650324
13lipoxygenase pathway (GO:0019372)4.82190787
14prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.63763522
15negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.60081826
16pericardium development (GO:0060039)4.54009080
17dendritic cell chemotaxis (GO:0002407)4.41850698
18negative regulation of DNA-templated transcription, elongation (GO:0032785)4.39632167
19positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.37216432
20negative regulation of execution phase of apoptosis (GO:1900118)4.35022639
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.31404877
22positive regulation of natural killer cell differentiation (GO:0032825)4.27412264
23positive regulation of endothelial cell differentiation (GO:0045603)4.17476491
24protein neddylation (GO:0045116)4.14520290
25receptor catabolic process (GO:0032801)4.10968844
26somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.10112313
27somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.10112313
28isotype switching (GO:0045190)4.10112313
29positive regulation of granulocyte differentiation (GO:0030854)4.09395719
30negative regulation of telomere maintenance (GO:0032205)4.06358675
31regulation of memory T cell differentiation (GO:0043380)4.02050596
32cellular response to ethanol (GO:0071361)3.87422865
33interleukin-6-mediated signaling pathway (GO:0070102)3.85192120
34regulation of B cell differentiation (GO:0045577)3.79166775
35regulation of chromatin binding (GO:0035561)3.78797442
36regulation of immunoglobulin secretion (GO:0051023)3.76160713
37inositol phosphate dephosphorylation (GO:0046855)3.70778294
38phosphorylated carbohydrate dephosphorylation (GO:0046838)3.70778294
39neutrophil mediated immunity (GO:0002446)3.69926389
40embryonic hemopoiesis (GO:0035162)3.65313113
41NAD biosynthetic process (GO:0009435)3.62067614
42regulation of icosanoid secretion (GO:0032303)3.57283346
43positive regulation of transforming growth factor beta production (GO:0071636)3.52659851
44positive regulation of endothelial cell apoptotic process (GO:2000353)3.50964722
45regulation of mitochondrial depolarization (GO:0051900)3.46250736
46positive regulation of protein import into nucleus, translocation (GO:0033160)3.43778169
47positive regulation of gamma-delta T cell activation (GO:0046645)3.42269971
48autophagic vacuole fusion (GO:0000046)3.41408754
49inositol phosphate catabolic process (GO:0071545)3.40700422
50histone H3-K4 trimethylation (GO:0080182)3.38239076
51dendritic cell migration (GO:0036336)3.37958161
52corticosteroid receptor signaling pathway (GO:0031958)3.32866648
53regulation of hypersensitivity (GO:0002883)3.31816951
54peptidyl-lysine trimethylation (GO:0018023)3.24612059
55negative thymic T cell selection (GO:0045060)3.23973080
56negative T cell selection (GO:0043383)3.15235715
57terpenoid biosynthetic process (GO:0016114)3.09725934
58thrombin receptor signaling pathway (GO:0070493)3.08865089
59hair cell differentiation (GO:0035315)3.05345924
60regulation of telomerase activity (GO:0051972)3.04585416
61early endosome to late endosome transport (GO:0045022)3.03729612
62inner ear receptor cell differentiation (GO:0060113)3.03217197
63purinergic nucleotide receptor signaling pathway (GO:0035590)3.00717176
64positive regulation of DNA biosynthetic process (GO:2000573)2.98430526
65myeloid leukocyte mediated immunity (GO:0002444)2.97518687
66growth hormone receptor signaling pathway (GO:0060396)2.95769086
67regulation of endothelial cell differentiation (GO:0045601)2.93932449
68positive regulation of interleukin-12 production (GO:0032735)2.93705294
69regulation of natural killer cell differentiation (GO:0032823)2.92352570
70cellular response to interleukin-15 (GO:0071350)2.91085619
71negative regulation of cAMP-mediated signaling (GO:0043951)2.90820879
72alternative mRNA splicing, via spliceosome (GO:0000380)2.90487606
73positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.89814767
74organelle membrane fusion (GO:0090174)2.89168061
75short-chain fatty acid metabolic process (GO:0046459)2.88494901
76regulation of regulatory T cell differentiation (GO:0045589)2.88263048
77peptidyl-histidine modification (GO:0018202)2.87128903
78regulation of female receptivity (GO:0045924)2.85837355
79venous blood vessel morphogenesis (GO:0048845)2.83937700
80negative regulation of stress fiber assembly (GO:0051497)2.80359922
81tyrosine phosphorylation of STAT protein (GO:0007260)2.79953512
82extracellular regulation of signal transduction (GO:1900115)2.79928357
83extracellular negative regulation of signal transduction (GO:1900116)2.79928357
84negative regulation of B cell apoptotic process (GO:0002903)2.79576171
85thymic T cell selection (GO:0045061)2.78990730
86Golgi to endosome transport (GO:0006895)2.77228819
87positive regulation of prostaglandin secretion (GO:0032308)2.77163552
88regulation of B cell apoptotic process (GO:0002902)2.74868456
89killing of cells of other organism (GO:0031640)2.74469741
90disruption of cells of other organism (GO:0044364)2.74469741
91positive regulation of natural killer cell activation (GO:0032816)2.73667324
92intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.73382553
93positive regulation of lymphocyte differentiation (GO:0045621)2.72770630
94cellular response to growth hormone stimulus (GO:0071378)2.71302374
95regulation of histone H3-K4 methylation (GO:0051569)2.70978139
96interleukin-1-mediated signaling pathway (GO:0070498)2.69264573
97negative regulation of interleukin-8 production (GO:0032717)2.68036367
98T cell mediated immunity (GO:0002456)2.67556728
99peptidyl-threonine dephosphorylation (GO:0035970)2.67438202
100cytidine catabolic process (GO:0006216)2.63494218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.82761500
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.71652378
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.65012312
4SCL_19346495_ChIP-Seq_HPC-7_Human3.20889121
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.06005049
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68273063
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.58526834
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54975775
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.50040963
10MYB_26560356_Chip-Seq_TH2_Human2.45297716
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42724493
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42056814
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.27868935
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23675911
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.16371401
16UTX_26944678_Chip-Seq_JUKART_Human2.13176511
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11143438
18RUNX_20019798_ChIP-Seq_JUKART_Human2.05597803
19VDR_21846776_ChIP-Seq_THP-1_Human2.03451243
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96090053
21GATA3_26560356_Chip-Seq_TH2_Human1.91688087
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90008260
23GATA3_27048872_Chip-Seq_THYMUS_Human1.88011507
24LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82867481
25VDR_24763502_ChIP-Seq_THP-1_Human1.81946336
26ETS1_22383799_ChIP-Seq_G1ME_Mouse1.80114649
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79863619
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73032070
29MYB_26560356_Chip-Seq_TH1_Human1.71467962
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.65988765
31ZNF274_21170338_ChIP-Seq_K562_Hela1.64589346
32TAF15_26573619_Chip-Seq_HEK293_Human1.64396914
33SPI1_23127762_ChIP-Seq_K562_Human1.60925639
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.60675639
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60505704
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55862561
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.53878794
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.52108634
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48477491
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.45608949
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44370795
42MAF_26560356_Chip-Seq_TH1_Human1.43641226
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43626328
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42701863
45MYC_22102868_ChIP-Seq_BL_Human1.36181488
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36066660
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35421351
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35107676
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31585597
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31420419
51GATA2_19941826_ChIP-Seq_K562_Human1.31040391
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.30718419
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26643197
54GBX2_23144817_ChIP-Seq_PC3_Human1.26067091
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25848752
56GATA1_19941826_ChIP-Seq_K562_Human1.25169845
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23123596
58VDR_23849224_ChIP-Seq_CD4+_Human1.22875923
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20845881
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.20076178
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17857267
62ER_23166858_ChIP-Seq_MCF-7_Human1.17002817
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16470309
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13269443
65NCOR1_26117541_ChIP-Seq_K562_Human1.12874622
66SPI1_23547873_ChIP-Seq_NB4_Human1.12815776
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12462489
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11864058
69ERA_21632823_ChIP-Seq_H3396_Human1.09418791
70CIITA_25753668_ChIP-Seq_RAJI_Human1.09192409
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07216109
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06257666
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05358741
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03683867
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.02251146
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00352264
77BCL6_27268052_Chip-Seq_Bcells_Human0.99534492
78BCOR_27268052_Chip-Seq_Bcells_Human0.97127806
79FOXP3_21729870_ChIP-Seq_TREG_Human0.96433559
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95871475
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95393491
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95325022
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94639668
84MAF_26560356_Chip-Seq_TH2_Human0.93940545
85SPI1_20517297_ChIP-Seq_HL60_Human0.93037392
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92454586
87P53_22387025_ChIP-Seq_ESCs_Mouse0.92394026
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91635461
89GATA3_21867929_ChIP-Seq_TH1_Mouse0.89692877
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89180657
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89014171
92P300_27268052_Chip-Seq_Bcells_Human0.87840096
93NANOG_20526341_ChIP-Seq_ESCs_Human0.87099175
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.85767245
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85238590
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84354189
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84080403
98CTCF_18555785_Chip-Seq_ESCs_Mouse0.82921755
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82730344
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.80175422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005174_abnormal_tail_pigmentation5.16762714
2MP0004264_abnormal_extraembryonic_tissu4.52037223
3MP0001835_abnormal_antigen_presentation4.38710364
4MP0005075_abnormal_melanosome_morpholog4.17023420
5MP0000372_irregular_coat_pigmentation3.74594568
6MP0004147_increased_porphyrin_level3.72429210
7MP0000015_abnormal_ear_pigmentation3.56040701
8MP0005464_abnormal_platelet_physiology3.26948289
9MP0000685_abnormal_immune_system2.70720164
10MP0005646_abnormal_pituitary_gland2.70358308
11MP0005671_abnormal_response_to2.48850930
12MP0000465_gastrointestinal_hemorrhage2.45318420
13MP0002095_abnormal_skin_pigmentation2.40231693
14MP0001800_abnormal_humoral_immune2.27931887
15MP0001873_stomach_inflammation2.18103016
16MP0001790_abnormal_immune_system2.16789180
17MP0005387_immune_system_phenotype2.16789180
18MP0002148_abnormal_hypersensitivity_rea2.05108194
19MP0002938_white_spotting2.02445870
20MP0000371_diluted_coat_color1.96680872
21MP0003172_abnormal_lysosome_physiology1.81882243
22MP0004885_abnormal_endolymph1.80488215
23MP0001545_abnormal_hematopoietic_system1.78015861
24MP0005397_hematopoietic_system_phenotyp1.78015861
25MP0002405_respiratory_system_inflammati1.77079282
26MP0002419_abnormal_innate_immunity1.75321484
27MP0003638_abnormal_response/metabolism_1.73607473
28MP0005000_abnormal_immune_tolerance1.69202221
29MP0001348_abnormal_lacrimal_gland1.66948090
30MP0002452_abnormal_antigen_presenting1.64375995
31MP0002723_abnormal_immune_serum1.58935969
32MP0002420_abnormal_adaptive_immunity1.50280290
33MP0001819_abnormal_immune_cell1.50087530
34MP0002398_abnormal_bone_marrow1.47538979
35MP0005025_abnormal_response_to1.46764027
36MP0004043_abnormal_pH_regulation1.46527987
37MP0004130_abnormal_muscle_cell1.46016560
38MP0004742_abnormal_vestibular_system1.42072580
39MP0002396_abnormal_hematopoietic_system1.37907181
40MP0009384_cardiac_valve_regurgitation1.36046769
41MP0003724_increased_susceptibility_to1.27708558
42MP0005379_endocrine/exocrine_gland_phen1.26720412
43MP0002722_abnormal_immune_system1.25569462
44MP0000689_abnormal_spleen_morphology1.22405451
45MP0003763_abnormal_thymus_physiology1.21871906
46MP0003011_delayed_dark_adaptation1.19676284
47MP0001984_abnormal_olfaction1.17319785
48MP0008961_abnormal_basal_metabolism1.15230451
49MP0000716_abnormal_immune_system1.14022581
50MP0000569_abnormal_digit_pigmentation1.08905830
51MP0003436_decreased_susceptibility_to1.07729744
52MP0006054_spinal_hemorrhage1.04430535
53MP0009785_altered_susceptibility_to1.00853854
54MP0002429_abnormal_blood_cell1.00222464
55MP0004859_abnormal_synaptic_plasticity0.99620031
56MP0008873_increased_physiological_sensi0.96527779
57MP0002877_abnormal_melanocyte_morpholog0.94398891
58MP0001845_abnormal_inflammatory_respons0.94242054
59MP0000013_abnormal_adipose_tissue0.92048085
60MP0009780_abnormal_chondrocyte_physiolo0.86946461
61MP0003656_abnormal_erythrocyte_physiolo0.86320955
62MP0000703_abnormal_thymus_morphology0.84535441
63MP0004381_abnormal_hair_follicle0.83740497
64MP0004084_abnormal_cardiac_muscle0.82695689
65MP0008569_lethality_at_weaning0.79792281
66MP0010155_abnormal_intestine_physiology0.77935509
67MP0002736_abnormal_nociception_after0.77864478
68MP0009763_increased_sensitivity_to0.77500934
69MP0008995_early_reproductive_senescence0.77225784
70MP0010386_abnormal_urinary_bladder0.77000927
71MP0002075_abnormal_coat/hair_pigmentati0.76509345
72MP0005083_abnormal_biliary_tract0.75612700
73MP0004947_skin_inflammation0.75456089
74MP0004808_abnormal_hematopoietic_stem0.73671233
75MP0005167_abnormal_blood-brain_barrier0.73482017
76MP0010329_abnormal_lipoprotein_level0.71842502
77MP0003329_amyloid_beta_deposits0.70795688
78MP0009765_abnormal_xenobiotic_induced0.70251236
79MP0003828_pulmonary_edema0.67749757
80MP0000639_abnormal_adrenal_gland0.67002810
81MP0002229_neurodegeneration0.64545852
82MP0005645_abnormal_hypothalamus_physiol0.63984081
83MP0002254_reproductive_system_inflammat0.62321862
84MP0008874_decreased_physiological_sensi0.61284724
85MP0000230_abnormal_systemic_arterial0.60738854
86MP0002166_altered_tumor_susceptibility0.60184241
87MP0008875_abnormal_xenobiotic_pharmacok0.59710045
88MP0002796_impaired_skin_barrier0.59672986
89MP0001186_pigmentation_phenotype0.58908312
90MP0002078_abnormal_glucose_homeostasis0.58622906
91MP0002837_dystrophic_cardiac_calcinosis0.57598365
92MP0009764_decreased_sensitivity_to0.56678510
93MP0008872_abnormal_physiological_respon0.56515775
94MP0005385_cardiovascular_system_phenoty0.56120394
95MP0001544_abnormal_cardiovascular_syste0.56120394
96MP0000604_amyloidosis0.56088531
97MP0002998_abnormal_bone_remodeling0.55111190
98MP0003866_abnormal_defecation0.54664912
99MP0003633_abnormal_nervous_system0.54659191
100MP0001851_eye_inflammation0.53898714

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.75225930
2Severe visual impairment (HP:0001141)5.07236981
3Large eyes (HP:0001090)4.84569875
4Thrombocytosis (HP:0001894)4.83452039
5IgG deficiency (HP:0004315)4.75711636
6Pulmonary fibrosis (HP:0002206)4.60509595
7Fatigue (HP:0012378)4.38674449
8Agammaglobulinemia (HP:0004432)4.29751766
9Increased IgM level (HP:0003496)4.15642594
10Panhypogammaglobulinemia (HP:0003139)4.15280474
11Failure to thrive in infancy (HP:0001531)3.72394234
12Xerostomia (HP:0000217)3.60828317
13Prolonged bleeding time (HP:0003010)3.58196974
14Hypertensive crisis (HP:0100735)3.43033584
15Abnormality of T cell physiology (HP:0011840)3.29168507
16Gingival bleeding (HP:0000225)3.14546021
17Abnormality of eosinophils (HP:0001879)3.12588892
18Epistaxis (HP:0000421)3.10014083
19Hypergammaglobulinemia (HP:0010702)3.01402374
20Gonadal dysgenesis (HP:0000133)2.98499334
21Peritonitis (HP:0002586)2.95926517
22Decreased central vision (HP:0007663)2.94541220
23Abnormality of T cells (HP:0002843)2.93618527
24Spontaneous abortion (HP:0005268)2.92759769
25Hepatitis (HP:0012115)2.89417486
26Eosinophilia (HP:0001880)2.82773853
27Eczematoid dermatitis (HP:0000976)2.81251813
28Granulocytopenia (HP:0001913)2.80346285
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.79519577
30Papilledema (HP:0001085)2.74640070
31Recurrent gram-negative bacterial infections (HP:0005420)2.69687699
32Tented upper lip vermilion (HP:0010804)2.69242110
33Leukocytosis (HP:0001974)2.68876336
34Cone-rod dystrophy (HP:0000548)2.68239495
35Abnormality of small intestinal villus morphology (HP:0011472)2.66991332
36Villous atrophy (HP:0011473)2.66991332
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.65878651
38IgA deficiency (HP:0002720)2.50986513
39Elevated erythrocyte sedimentation rate (HP:0003565)2.50102708
40Recurrent cutaneous fungal infections (HP:0011370)2.49329319
41Chronic mucocutaneous candidiasis (HP:0002728)2.49329319
42Pustule (HP:0200039)2.48071206
43Anteriorly placed anus (HP:0001545)2.47433147
44Clumsiness (HP:0002312)2.46593698
45Mucosal telangiectasiae (HP:0100579)2.44844762
46Joint swelling (HP:0001386)2.43855811
47Abnormality of iron homeostasis (HP:0011031)2.43551458
48Increased serum ferritin (HP:0003281)2.42242370
49Chest pain (HP:0100749)2.41934937
50Acute myeloid leukemia (HP:0004808)2.41687192
51Abnormality of transition element cation homeostasis (HP:0011030)2.38511602
52Pulmonary infiltrates (HP:0002113)2.35428315
53Septate vagina (HP:0001153)2.33101357
54Myocardial infarction (HP:0001658)2.32476731
55Recurrent fungal infections (HP:0002841)2.30577887
56Sensory axonal neuropathy (HP:0003390)2.29609484
57Hypoplasia of the thymus (HP:0000778)2.27044514
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.21618220
59Nemaline bodies (HP:0003798)2.18016638
60Limb hypertonia (HP:0002509)2.17638076
61Sensorimotor neuropathy (HP:0007141)2.17026890
62Neutropenia (HP:0001875)2.15681606
63Severe combined immunodeficiency (HP:0004430)2.14301901
64Widely spaced teeth (HP:0000687)2.11971326
65Recurrent bronchitis (HP:0002837)2.08750437
66Teleangiectasia of the skin (HP:0100585)2.08394096
67Viral hepatitis (HP:0006562)2.05378809
68Hematochezia (HP:0002573)2.04904109
69Hyperglycinemia (HP:0002154)2.04342675
70Supernumerary bones of the axial skeleton (HP:0009144)2.03418172
71Increased number of teeth (HP:0011069)2.02921102
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.02278921
73Weak cry (HP:0001612)2.02140529
74Acute hepatic failure (HP:0006554)1.98917050
75Enlarged epiphyses (HP:0010580)1.97212331
76Abnormality of the renal medulla (HP:0100957)1.95696895
77Exertional dyspnea (HP:0002875)1.95490047
78Portal hypertension (HP:0001409)1.94604388
79Amaurosis fugax (HP:0100576)1.93680468
80Colitis (HP:0002583)1.93513351
81Poikilocytosis (HP:0004447)1.92684602
82Tongue fasciculations (HP:0001308)1.89837752
83Skin rash (HP:0000988)1.88809269
84Camptodactyly of toe (HP:0001836)1.88699967
85Arterial thrombosis (HP:0004420)1.88641757
86Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88279179
87Absent speech (HP:0001344)1.87612158
88Facial diplegia (HP:0001349)1.87323986
89Gastrointestinal infarctions (HP:0005244)1.87097858
90Abnormality of the pancreatic islet cells (HP:0006476)1.86852274
91Abnormality of endocrine pancreas physiology (HP:0012093)1.86852274
92Tinnitus (HP:0000360)1.85893082
93Abnormality of carpal bone ossification (HP:0006257)1.84832144
94Progressive microcephaly (HP:0000253)1.83450533
95Glomerulopathy (HP:0100820)1.81958157
96Polycythemia (HP:0001901)1.81110848
97Abnormality of the heme biosynthetic pathway (HP:0010472)1.80639260
98Nephronophthisis (HP:0000090)1.80607425
99Abnormality of the hepatic vasculature (HP:0006707)1.79488492
100Attenuation of retinal blood vessels (HP:0007843)1.79027677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.71668175
2TNK22.61086328
3MAP4K22.31369201
4MAP4K12.13963596
5TAOK314.4610929
6CDK81.83065908
7MAP2K31.67287114
8ERN11.64074157
9TESK21.56887125
10BMPR1B1.52585957
11ACVR1B1.44315458
12KDR1.43984001
13KIT1.41755744
14EPHA31.20987989
15TBK11.14369548
16SCYL21.14267406
17ZAK0.91793331
18JAK30.85512215
19FES0.85501711
20MATK0.85373124
21MAP3K10.80148451
22CSF1R0.74620155
23GRK60.70520309
24TXK0.67741314
25MAP3K30.65265420
26NTRK20.63543538
27BCKDK0.62739749
28MAP3K130.62377229
29SYK0.61942492
30TEC0.61929877
31MAP3K140.61631424
32PASK0.59904105
33FGFR10.56345727
34IKBKB0.54856917
35BTK0.54714135
36MAP2K40.52932289
37MAP2K20.44762434
38FRK0.44523323
39PRPF4B0.44390345
40TESK10.43627974
41RIPK40.43534515
42ZAP700.42175589
43LCK0.40831909
44PRKCH0.40695612
45PIM20.40514560
46ADRBK20.40093707
47PIK3CA0.38054012
48TGFBR10.37788423
49RIPK10.37114973
50CAMKK10.36375969
51GRK10.36302074
52OBSCN0.35792597
53LYN0.34802068
54PIK3CG0.33876100
55FGFR30.33299949
56ITK0.32076323
57MAP2K10.31861933
58MAPK70.31282812
59EPHB10.30686855
60FGR0.30674244
61EIF2AK10.30440365
62IKBKE0.30114758
63MAP3K110.30076695
64MAP3K70.29487940
65JAK10.29232342
66WNK40.28644341
67HCK0.28236130
68PRKCQ0.27498082
69ADRBK10.27055683
70YES10.26595888
71MAPK120.25396121
72PIM10.25176245
73FLT30.23456540
74MAPK30.23273300
75FER0.20308245
76JAK20.19991148
77NLK0.19855111
78CCNB10.19258226
79BMX0.17910690
80TYK20.17709074
81PRKACB0.17474138
82SGK20.16462872
83ATR0.14784518
84DAPK20.14760994
85LIMK10.14702027
86PRKCE0.14278839
87STK30.14139642
88SGK30.14100537
89TRPM70.14086734
90IGF1R0.13072742
91MYLK0.12471839
92PRKG10.11453997
93RET0.11181740
94BMPR20.10751323
95TLK10.10294022
96PLK20.08984155
97PRKCA0.08651383
98IRAK10.08575866
99SRC0.08233854
100MAPKAPK20.07967370

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.96288231
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.19374171
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.10566365
4Asthma_Homo sapiens_hsa053102.83357632
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41732850
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38479213
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32301477
8Fatty acid biosynthesis_Homo sapiens_hsa000612.14425213
9Renin-angiotensin system_Homo sapiens_hsa046142.13179680
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.06653896
11Allograft rejection_Homo sapiens_hsa053301.95473735
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94874311
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.92720172
14T cell receptor signaling pathway_Homo sapiens_hsa046601.82185327
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.77862519
16Platelet activation_Homo sapiens_hsa046111.72537219
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.59574269
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55448327
19Hematopoietic cell lineage_Homo sapiens_hsa046401.53871922
20Autoimmune thyroid disease_Homo sapiens_hsa053201.50380318
21B cell receptor signaling pathway_Homo sapiens_hsa046621.45889544
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.37865769
23Nitrogen metabolism_Homo sapiens_hsa009101.33067318
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29195494
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.27863187
26Vitamin B6 metabolism_Homo sapiens_hsa007501.21564822
27Phototransduction_Homo sapiens_hsa047441.21355079
28Spliceosome_Homo sapiens_hsa030401.14722515
29Systemic lupus erythematosus_Homo sapiens_hsa053221.08271188
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07255256
31Pentose phosphate pathway_Homo sapiens_hsa000301.06456181
32ABC transporters_Homo sapiens_hsa020101.06367660
33Chemokine signaling pathway_Homo sapiens_hsa040621.03523342
34Malaria_Homo sapiens_hsa051441.03460623
35Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99869772
36Arachidonic acid metabolism_Homo sapiens_hsa005900.99110245
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96335550
38Sulfur metabolism_Homo sapiens_hsa009200.94273379
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91663485
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91120517
41Acute myeloid leukemia_Homo sapiens_hsa052210.91010526
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88794642
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87523652
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86715895
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86027753
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84724207
47Chemical carcinogenesis_Homo sapiens_hsa052040.83910876
48Fatty acid metabolism_Homo sapiens_hsa012120.83095949
49Osteoclast differentiation_Homo sapiens_hsa043800.83052855
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82389916
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81942394
52Antigen processing and presentation_Homo sapiens_hsa046120.80933224
53Olfactory transduction_Homo sapiens_hsa047400.80159280
54Salivary secretion_Homo sapiens_hsa049700.80066324
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78793514
56GABAergic synapse_Homo sapiens_hsa047270.78764332
57Circadian entrainment_Homo sapiens_hsa047130.78478257
58Gastric acid secretion_Homo sapiens_hsa049710.78002757
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76432253
60Measles_Homo sapiens_hsa051620.76120677
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.75754948
62Inositol phosphate metabolism_Homo sapiens_hsa005620.75701636
63Leishmaniasis_Homo sapiens_hsa051400.73370485
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72481288
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.71704536
66Calcium signaling pathway_Homo sapiens_hsa040200.71616882
67Morphine addiction_Homo sapiens_hsa050320.71021158
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.69063054
69Ovarian steroidogenesis_Homo sapiens_hsa049130.69010525
70Basal transcription factors_Homo sapiens_hsa030220.68360136
71Fatty acid elongation_Homo sapiens_hsa000620.66972220
72Nicotine addiction_Homo sapiens_hsa050330.66636331
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.66592981
74Sphingolipid metabolism_Homo sapiens_hsa006000.60885417
75Propanoate metabolism_Homo sapiens_hsa006400.58886783
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58811096
77Phenylalanine metabolism_Homo sapiens_hsa003600.58249417
78Herpes simplex infection_Homo sapiens_hsa051680.57313963
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56832710
80Viral myocarditis_Homo sapiens_hsa054160.56218762
81Apoptosis_Homo sapiens_hsa042100.56036992
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52824611
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52683349
84Long-term depression_Homo sapiens_hsa047300.50349937
85Sulfur relay system_Homo sapiens_hsa041220.49446313
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47210992
87Dilated cardiomyopathy_Homo sapiens_hsa054140.46201971
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43854970
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42411147
90Cholinergic synapse_Homo sapiens_hsa047250.40839575
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.40291258
92HTLV-I infection_Homo sapiens_hsa051660.39860106
93Pancreatic secretion_Homo sapiens_hsa049720.39580639
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39074876
95Nucleotide excision repair_Homo sapiens_hsa034200.37917350
96Tuberculosis_Homo sapiens_hsa051520.37043772
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35445545
98Influenza A_Homo sapiens_hsa051640.35310268
99Alzheimers disease_Homo sapiens_hsa050100.34992925
100Insulin secretion_Homo sapiens_hsa049110.34496733

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