SCN10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)8.70228758
2detection of temperature stimulus involved in sensory perception (GO:0050961)8.70228758
3detection of temperature stimulus (GO:0016048)8.42072177
4negative regulation of dendrite morphogenesis (GO:0050774)7.68465417
5neurofilament cytoskeleton organization (GO:0060052)7.42773035
6leukotriene metabolic process (GO:0006691)7.17292139
7behavioral response to pain (GO:0048266)6.55426848
8urinary tract smooth muscle contraction (GO:0014848)6.37255684
9negative regulation of complement activation (GO:0045916)6.30241300
10* neuronal action potential (GO:0019228)6.20304377
11peripheral nervous system neuron development (GO:0048935)6.19978020
12response to pain (GO:0048265)5.88484965
13adenosine metabolic process (GO:0046085)5.87643910
14fatty acid derivative biosynthetic process (GO:1901570)5.69299575
15icosanoid biosynthetic process (GO:0046456)5.69299575
16plasma membrane fusion (GO:0045026)5.57419156
17serotonin metabolic process (GO:0042428)5.54951910
18potassium ion export (GO:0071435)5.42830624
19proline transport (GO:0015824)5.26184310
20glutathione metabolic process (GO:0006749)5.26151420
21negative regulation of protein activation cascade (GO:2000258)5.21717067
22negative regulation of protein localization to cell surface (GO:2000009)5.11694364
23negative regulation of dendrite development (GO:2000171)4.99812004
24unsaturated fatty acid biosynthetic process (GO:0006636)4.97697119
25regulation of sarcomere organization (GO:0060297)4.97163823
26mitochondrion distribution (GO:0048311)4.95853814
27cilium or flagellum-dependent cell motility (GO:0001539)4.90987456
28positive regulation of synaptic transmission, GABAergic (GO:0032230)4.79000939
29enteric nervous system development (GO:0048484)4.76854830
30postsynaptic membrane organization (GO:0001941)4.76800355
31primary amino compound metabolic process (GO:1901160)4.73769720
32positive regulation of muscle hypertrophy (GO:0014742)4.71269872
33positive regulation of cardiac muscle hypertrophy (GO:0010613)4.71269872
34peristalsis (GO:0030432)4.60075863
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.53323927
36phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.47404310
37signal peptide processing (GO:0006465)4.46243784
38* membrane depolarization during action potential (GO:0086010)4.31294469
39regulation of platelet aggregation (GO:0090330)4.31110876
40negative regulation of humoral immune response (GO:0002921)4.27133024
41cell migration in hindbrain (GO:0021535)4.26505746
42ovulation cycle (GO:0042698)4.26264408
43myoblast fusion (GO:0007520)4.26103911
44peptide catabolic process (GO:0043171)4.22951507
45response to ATP (GO:0033198)4.20289393
46behavioral response to nicotine (GO:0035095)4.19627872
47membrane repolarization (GO:0086009)4.16833639
48regulation of skeletal muscle contraction (GO:0014819)4.14959860
49detection of mechanical stimulus involved in sensory perception (GO:0050974)4.13324178
50axon cargo transport (GO:0008088)4.09962799
51retinal cone cell development (GO:0046549)4.09165917
52negative regulation of homotypic cell-cell adhesion (GO:0034111)4.05688105
53response to water (GO:0009415)4.04769508
54negative regulation of calcium ion transport into cytosol (GO:0010523)4.04453711
55syncytium formation (GO:0006949)4.03998368
56regulation of cilium movement (GO:0003352)4.00847180
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.95249585
58multicellular organismal movement (GO:0050879)3.94943934
59musculoskeletal movement (GO:0050881)3.94943934
60muscle cell cellular homeostasis (GO:0046716)3.93333637
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.91695645
62negative regulation of microtubule polymerization (GO:0031115)3.88147279
63regulation of sensory perception (GO:0051931)3.86842221
64regulation of sensory perception of pain (GO:0051930)3.86842221
65neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.81776929
66alanine transport (GO:0032328)3.72954891
67sodium ion export (GO:0071436)3.72028963
68cellular potassium ion homeostasis (GO:0030007)3.71246790
69neuromuscular synaptic transmission (GO:0007274)3.71169462
70syncytium formation by plasma membrane fusion (GO:0000768)3.68810662
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68640833
72cysteine metabolic process (GO:0006534)3.68256386
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.65429599
74establishment of mitochondrion localization (GO:0051654)3.61943540
75neuronal action potential propagation (GO:0019227)3.60170921
76indole-containing compound metabolic process (GO:0042430)3.59829508
77alkaloid metabolic process (GO:0009820)3.59352849
78actin-myosin filament sliding (GO:0033275)3.56032008
79muscle filament sliding (GO:0030049)3.56032008
80response to gravity (GO:0009629)3.51960876
81brain morphogenesis (GO:0048854)3.48801925
82synaptic vesicle maturation (GO:0016188)3.48564203
83microglial cell activation (GO:0001774)3.47694779
84indolalkylamine metabolic process (GO:0006586)3.45799465
85photoreceptor cell maintenance (GO:0045494)3.45398024
86* action potential (GO:0001508)3.45325597
87glutamate secretion (GO:0014047)3.44567577
88positive regulation of microtubule polymerization (GO:0031116)3.43199821
89cellular modified amino acid catabolic process (GO:0042219)3.41008472
90retinal ganglion cell axon guidance (GO:0031290)3.39785421
91cellular response to nicotine (GO:0071316)3.38861894
92acrosome reaction (GO:0007340)3.38801333
93positive regulation of amino acid transport (GO:0051957)3.38062151
94positive regulation of potassium ion transmembrane transport (GO:1901381)3.34577835
95plasma membrane repair (GO:0001778)3.32777251
96regulation of microtubule-based movement (GO:0060632)3.29381102
97synaptic transmission, cholinergic (GO:0007271)3.27899328
98negative regulation of sodium ion transport (GO:0010766)3.25809139
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.25343939
100regulation of amyloid precursor protein catabolic process (GO:1902991)3.24912431
101multicellular organismal response to stress (GO:0033555)3.24499855
102positive regulation of developmental pigmentation (GO:0048087)3.24228769
103dopamine receptor signaling pathway (GO:0007212)3.22824799
104regulation of collateral sprouting (GO:0048670)3.22631284
105neural tube formation (GO:0001841)3.20924836
106vesicle transport along microtubule (GO:0047496)3.18022358
107intermediate filament organization (GO:0045109)3.16778628
108glomerular visceral epithelial cell development (GO:0072015)3.16635410
109cellular response to prostaglandin stimulus (GO:0071379)3.15557792
110regulation of synaptic vesicle exocytosis (GO:2000300)3.13008902
111respiratory tube development (GO:0030323)3.12496168
112glycosphingolipid biosynthetic process (GO:0006688)3.11513421
113fatty acid biosynthetic process (GO:0006633)3.11298048
114cellular sodium ion homeostasis (GO:0006883)3.10580640
115organelle transport along microtubule (GO:0072384)3.09599921
116intermediate filament-based process (GO:0045103)3.08812130
117mitochondrion transport along microtubule (GO:0047497)3.07536908
118establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07536908
119regulation of sodium ion transmembrane transporter activity (GO:2000649)3.05817290
120intermediate filament cytoskeleton organization (GO:0045104)3.05669862
121regulation of homotypic cell-cell adhesion (GO:0034110)3.05547725
122membrane budding (GO:0006900)3.01534349
123* sodium ion transmembrane transport (GO:0035725)3.00882274
124microtubule nucleation (GO:0007020)3.00722425
125fatty acid derivative metabolic process (GO:1901568)2.99589086
126icosanoid metabolic process (GO:0006690)2.99589086
127actin filament capping (GO:0051693)2.97468631
128actin-mediated cell contraction (GO:0070252)2.97041871
129protein-chromophore linkage (GO:0018298)2.95810406
130calcium ion-dependent exocytosis (GO:0017156)2.95418147
131axon development (GO:0061564)2.94279740
132regulation of neurotransmitter uptake (GO:0051580)2.93852756
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92816241
134xenobiotic catabolic process (GO:0042178)2.91866852
135neurotransmitter uptake (GO:0001504)2.91805951
136epithelial cilium movement (GO:0003351)2.91300445
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90649759
138regulation of beta-amyloid formation (GO:1902003)2.90516319
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90320548
140* regulation of striated muscle contraction (GO:0006942)2.90104283
141glycine transport (GO:0015816)2.90036655
142cell morphogenesis involved in neuron differentiation (GO:0048667)2.89754389
143coenzyme catabolic process (GO:0009109)2.88887632
144regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87840501
145cilium movement (GO:0003341)2.87258518
146protein ADP-ribosylation (GO:0006471)2.86209747
147positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.85860871
148regulation of pigment cell differentiation (GO:0050932)2.85827136
149negative regulation of protein polymerization (GO:0032272)2.85606813
150cellular ketone body metabolic process (GO:0046950)2.83830303
151sensory perception of taste (GO:0050909)2.82925581
152regulation of translational termination (GO:0006449)2.82088913
153regulation of cell communication by electrical coupling (GO:0010649)2.82056533
154regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.81075405
155regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.81075405
156glomerular epithelial cell development (GO:0072310)2.80922795
157peptide metabolic process (GO:0006518)2.79844856
158positive regulation of potassium ion transport (GO:0043268)2.79504926
159regulation of early endosome to late endosome transport (GO:2000641)2.78983877
160endosome to melanosome transport (GO:0035646)2.78962210
161endosome to pigment granule transport (GO:0043485)2.78962210
162striated muscle atrophy (GO:0014891)2.77526596
163detection of molecule of bacterial origin (GO:0032490)2.77457293
164negative regulation of appetite (GO:0032099)2.76459487
165negative regulation of response to food (GO:0032096)2.76459487
166innervation (GO:0060384)2.76357527
167protein polyglutamylation (GO:0018095)2.76332523
168multicellular organism reproduction (GO:0032504)2.76041366
169sperm motility (GO:0030317)2.75842480
170negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.75820120
171tachykinin receptor signaling pathway (GO:0007217)2.75612554
172regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75321583
173negative regulation of inclusion body assembly (GO:0090084)2.74940920
174negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.74816935
175response to misfolded protein (GO:0051788)2.74696085
176nerve growth factor signaling pathway (GO:0038180)2.74069240
177purinergic nucleotide receptor signaling pathway (GO:0035590)2.73864396
178negative regulation of cation channel activity (GO:2001258)2.73842661
179detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73734643
180regulation of cAMP-dependent protein kinase activity (GO:2000479)2.73566726
181striatum development (GO:0021756)2.73125127
182regulation of cardiac muscle hypertrophy (GO:0010611)2.72791582
183regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.72490445
184unsaturated fatty acid metabolic process (GO:0033559)2.68252068
185gamma-aminobutyric acid signaling pathway (GO:0007214)2.65733140
186indole-containing compound catabolic process (GO:0042436)2.64184953
187indolalkylamine catabolic process (GO:0046218)2.64184953
188tryptophan catabolic process (GO:0006569)2.64184953
189fusion of sperm to egg plasma membrane (GO:0007342)2.61674326
190regulation of establishment of cell polarity (GO:2000114)2.60052392
191appendage development (GO:0048736)2.58413821
192limb development (GO:0060173)2.58413821
193leukotriene biosynthetic process (GO:0019370)10.5840296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR2_21235772_ChIP-Seq_MCF-7_Human2.83149116
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71901688
3ESR1_20079471_ChIP-ChIP_T-47D_Human2.69049690
4EZH2_22144423_ChIP-Seq_EOC_Human2.68653926
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60052901
6ZNF263_19887448_ChIP-Seq_K562_Human2.54577925
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38764556
8* VDR_22108803_ChIP-Seq_LS180_Human2.34490904
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33225982
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32436654
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32436654
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31482879
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28025515
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23627536
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21478959
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14659638
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11010250
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10764697
19GBX2_23144817_ChIP-Seq_PC3_Human2.10749323
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.10590695
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09377134
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06946802
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05525693
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.03684395
25* REST_21632747_ChIP-Seq_MESCs_Mouse2.01679278
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.91932704
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.91370616
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90436645
29ER_23166858_ChIP-Seq_MCF-7_Human1.89835289
30NR3C1_23031785_ChIP-Seq_PC12_Mouse1.89479902
31SMAD4_21799915_ChIP-Seq_A2780_Human1.89039042
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88676626
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85736381
34* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80209890
35* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80209890
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.79623497
37* REST_18959480_ChIP-ChIP_MESCs_Mouse1.78240878
38EGR1_19032775_ChIP-ChIP_M12_Human1.75759559
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.75260355
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74815397
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73368038
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.72904206
43CBP_20019798_ChIP-Seq_JUKART_Human1.70591456
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70591456
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70279458
46TAF15_26573619_Chip-Seq_HEK293_Human1.69864777
47CTCF_27219007_Chip-Seq_Bcells_Human1.65222843
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64458739
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61229861
50FUS_26573619_Chip-Seq_HEK293_Human1.61222423
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58772246
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.58453371
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57319762
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.56437308
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54683504
56AHR_22903824_ChIP-Seq_MCF-7_Human1.53785323
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.53431723
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52859271
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51785245
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50367619
61CJUN_26792858_Chip-Seq_BT549_Human1.49030818
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.48352174
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47764333
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44156605
65KDM2B_26808549_Chip-Seq_K562_Human1.42231012
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.42187006
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42054099
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40505293
69* TCF4_23295773_ChIP-Seq_U87_Human1.39090763
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.37847099
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37799106
72TET1_21490601_ChIP-Seq_MESCs_Mouse1.34594598
73TCF4_22108803_ChIP-Seq_LS180_Human1.33157670
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33069657
75SMAD4_21741376_ChIP-Seq_HESCs_Human1.32180549
76RUNX2_22187159_ChIP-Seq_PCA_Human1.30453552
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29492771
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.27652302
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27614152
80CDX2_22108803_ChIP-Seq_LS180_Human1.27267352
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26522616
82* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25943400
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25322895
84ZNF274_21170338_ChIP-Seq_K562_Hela1.22963360
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.22140677
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.21598949
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20405096
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19807791
89* TCF4_18268006_ChIP-ChIP_LS174T_Human1.18747180
90SMAD3_21741376_ChIP-Seq_ESCs_Human1.17016016
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16970719
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16155367
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15714495
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15680097
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15483493
96* EP300_21415370_ChIP-Seq_HL-1_Mouse1.14893141
97BCAT_22108803_ChIP-Seq_LS180_Human1.14792669
98STAT3_23295773_ChIP-Seq_U87_Human1.14757045
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13134509
100OCT1_27270436_Chip-Seq_PROSTATE_Human1.11510988
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11481347
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.11435254
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11410516
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10506322
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10364581
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10307603
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10263140
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10121842
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.09687131
110* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08389149
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07575524
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06317490
113RXR_22108803_ChIP-Seq_LS180_Human1.05819437
114P53_22387025_ChIP-Seq_ESCs_Mouse1.05142911
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.04940297
116P300_18555785_Chip-Seq_ESCs_Mouse1.04686326
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04269399
118P300_19829295_ChIP-Seq_ESCs_Human1.04143802
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.04050786
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.02921034
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02517429
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02503749
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02240495
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02045822
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.01994931
126DROSHA_22980978_ChIP-Seq_HELA_Human1.00997693
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00880736
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.00880736
129SOX2_19829295_ChIP-Seq_ESCs_Human1.00142767
130NANOG_19829295_ChIP-Seq_ESCs_Human1.00142767
131CEBPB_22108803_ChIP-Seq_LS180_Human0.99255648
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98440625
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.98266647
134* AR_19668381_ChIP-Seq_PC3_Human0.98260158
135AR_25329375_ChIP-Seq_VCAP_Human0.97425732
136KLF4_19829295_ChIP-Seq_ESCs_Human0.96456641
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95841690
138* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95457902
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94796890
140* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94614915
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94493956
142AR_21572438_ChIP-Seq_LNCaP_Human0.94328574
143KDM2B_26808549_Chip-Seq_REH_Human0.93628031
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93296992
145* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90223239
146* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89813498
147IGF1R_20145208_ChIP-Seq_DFB_Human0.89799111
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89229028
149PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.88787185
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88786332
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88703210
152SOX2_20726797_ChIP-Seq_SW620_Human0.88605543
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88110744
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87696909
155PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87148898
156GATA1_22025678_ChIP-Seq_K562_Human0.86614450
157RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86164357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception8.58156106
2* MP0001968_abnormal_touch/_nociception7.78470244
3* MP0002736_abnormal_nociception_after6.44804587
4MP0001986_abnormal_taste_sensitivity5.55265791
5MP0003136_yellow_coat_color4.90359097
6* MP0002733_abnormal_thermal_nociception4.57586433
7MP0002734_abnormal_mechanical_nocicepti4.51647146
8MP0004270_analgesia4.44935264
9MP0006276_abnormal_autonomic_nervous4.14383219
10MP0004858_abnormal_nervous_system4.02898734
11* MP0001970_abnormal_pain_threshold3.75894573
12MP0002638_abnormal_pupillary_reflex3.18832195
13MP0003195_calcinosis2.66109546
14MP0003950_abnormal_plasma_membrane2.63218079
15MP0002163_abnormal_gland_morphology2.45114747
16MP0001501_abnormal_sleep_pattern2.33002213
17MP0005551_abnormal_eye_electrophysiolog2.25940727
18MP0002089_abnormal_postnatal_growth/wei2.13083088
19MP0005310_abnormal_salivary_gland2.09089884
20MP0001485_abnormal_pinna_reflex2.07272923
21* MP0002272_abnormal_nervous_system2.07153545
22MP0005253_abnormal_eye_physiology2.00345891
23MP0004859_abnormal_synaptic_plasticity1.99690100
24MP0002751_abnormal_autonomic_nervous1.94749532
25MP0003011_delayed_dark_adaptation1.94161162
26MP0003656_abnormal_erythrocyte_physiolo1.91854236
27MP0005171_absent_coat_pigmentation1.91122161
28* MP0002067_abnormal_sensory_capabilities1.90495211
29MP0002184_abnormal_innervation1.79495133
30MP0003329_amyloid_beta_deposits1.76599736
31MP0002138_abnormal_hepatobiliary_system1.67195180
32MP0003646_muscle_fatigue1.65836203
33MP0002822_catalepsy1.64563330
34MP0001270_distended_abdomen1.62251813
35MP0008995_early_reproductive_senescence1.61210926
36MP0003878_abnormal_ear_physiology1.59263345
37MP0005377_hearing/vestibular/ear_phenot1.59263345
38MP0005379_endocrine/exocrine_gland_phen1.57649377
39MP0008260_abnormal_autophagy1.50547544
40MP0004381_abnormal_hair_follicle1.49087581
41MP0003635_abnormal_synaptic_transmissio1.48216734
42MP0005083_abnormal_biliary_tract1.47717812
43MP0005410_abnormal_fertilization1.44797189
44MP0004811_abnormal_neuron_physiology1.43080028
45MP0004742_abnormal_vestibular_system1.38789326
46MP0004043_abnormal_pH_regulation1.36956435
47MP0000371_diluted_coat_color1.36486364
48MP0009053_abnormal_anal_canal1.34052232
49MP0000955_abnormal_spinal_cord1.31836929
50MP0001348_abnormal_lacrimal_gland1.27459544
51MP0000372_irregular_coat_pigmentation1.26153357
52MP0005187_abnormal_penis_morphology1.25291257
53MP0005174_abnormal_tail_pigmentation1.24668254
54MP0005423_abnormal_somatic_nervous1.23448997
55MP0003879_abnormal_hair_cell1.15038833
56MP0005620_abnormal_muscle_contractility1.12391031
57MP0003252_abnormal_bile_duct1.08967915
58MP0000015_abnormal_ear_pigmentation1.08740778
59MP0000604_amyloidosis1.08551984
60MP0009046_muscle_twitch1.08412641
61MP0003880_abnormal_central_pattern1.06193051
62MP0002063_abnormal_learning/memory/cond1.05787269
63MP0002837_dystrophic_cardiac_calcinosis1.03376415
64MP0009745_abnormal_behavioral_response1.02164085
65MP0002928_abnormal_bile_duct1.02018201
66MP0003633_abnormal_nervous_system1.00551840
67MP0002064_seizures1.00173104
68MP0001299_abnormal_eye_distance/0.98673892
69MP0000749_muscle_degeneration0.97234724
70MP0002108_abnormal_muscle_morphology0.96587972
71MP0001984_abnormal_olfaction0.96135112
72MP0003300_gastrointestinal_ulcer0.95547357
73MP0003959_abnormal_lean_body0.95090526
74MP0001502_abnormal_circadian_rhythm0.94828352
75MP0002090_abnormal_vision0.94660494
76MP0000613_abnormal_salivary_gland0.93756894
77MP0003698_abnormal_male_reproductive0.93743449
78MP0000747_muscle_weakness0.93383987
79MP0002882_abnormal_neuron_morphology0.91647507
80MP0001963_abnormal_hearing_physiology0.89809678
81MP0008874_decreased_physiological_sensi0.89081794
82* MP0010771_integument_phenotype0.87921401
83MP0003183_abnormal_peptide_metabolism0.87781630
84MP0002572_abnormal_emotion/affect_behav0.86984322
85MP0003634_abnormal_glial_cell0.86790330
86MP0005058_abnormal_lysosome_morphology0.86704494
87MP0001873_stomach_inflammation0.86351686
88MP0000538_abnormal_urinary_bladder0.85676688
89MP0003045_fibrosis0.85311666
90MP0000751_myopathy0.84165321
91MP0002909_abnormal_adrenal_gland0.81403131
92MP0000534_abnormal_ureter_morphology0.81154500
93MP0003279_aneurysm0.80601562
94MP0000647_abnormal_sebaceous_gland0.78805666
95MP0003631_nervous_system_phenotype0.78541235
96MP0002132_abnormal_respiratory_system0.78266961
97MP0008877_abnormal_DNA_methylation0.77537892
98MP0000778_abnormal_nervous_system0.76657245
99MP0002229_neurodegeneration0.75962200
100MP0004885_abnormal_endolymph0.75557402
101MP0009250_abnormal_appendicular_skeleto0.74886609
102MP0001929_abnormal_gametogenesis0.74174000
103MP0002095_abnormal_skin_pigmentation0.73335157
104MP0000920_abnormal_myelination0.73192658
105MP0005670_abnormal_white_adipose0.72631140
106MP0000427_abnormal_hair_cycle0.71047325
107MP0002066_abnormal_motor_capabilities/c0.70485166
108MP0004036_abnormal_muscle_relaxation0.70117184
109MP0000579_abnormal_nail_morphology0.68293083
110MP0010234_abnormal_vibrissa_follicle0.67066150
111MP0010386_abnormal_urinary_bladder0.64834133
112MP0001440_abnormal_grooming_behavior0.60911058
113MP0004130_abnormal_muscle_cell0.58843173
114MP0002972_abnormal_cardiac_muscle0.57188874
115MP0002752_abnormal_somatic_nervous0.56604826
116MP0003172_abnormal_lysosome_physiology0.54978207
117MP0001664_abnormal_digestion0.52389605
118MP0000569_abnormal_digit_pigmentation0.52035796
119MP0005386_behavior/neurological_phenoty0.51273978
120MP0004924_abnormal_behavior0.51273978
121MP0003868_abnormal_feces_composition0.51258868
122MP0008569_lethality_at_weaning0.51206778
123MP0004085_abnormal_heartbeat0.50496490
124MP0002557_abnormal_social/conspecific_i0.50184752
125MP0004142_abnormal_muscle_tone0.49725904
126MP0004147_increased_porphyrin_level0.48926320
127MP0003806_abnormal_nucleotide_metabolis0.48490220
128MP0005165_increased_susceptibility_to0.48372954
129MP0001905_abnormal_dopamine_level0.47024320
130MP0002269_muscular_atrophy0.46379186
131MP0004084_abnormal_cardiac_muscle0.45655217
132MP0009697_abnormal_copulation0.42125416
133MP0004145_abnormal_muscle_electrophysio0.41735718
134MP0003632_abnormal_nervous_system0.40932333
135MP0004215_abnormal_myocardial_fiber0.40573261
136MP0004883_abnormal_blood_vessel0.38311413
137MP0001756_abnormal_urination0.37708634
138MP0008961_abnormal_basal_metabolism0.35616249
139MP0009780_abnormal_chondrocyte_physiolo0.34680893
140MP0008775_abnormal_heart_ventricle0.34141182
141MP0000759_abnormal_skeletal_muscle0.33485833
142MP0000681_abnormal_thyroid_gland0.33169477
143MP0005535_abnormal_body_temperature0.32183772
144MP0008872_abnormal_physiological_respon0.31957318
145MP0000230_abnormal_systemic_arterial0.31716020
146MP0004484_altered_response_of0.30653280
147MP0004510_myositis0.30051930
148MP0003137_abnormal_impulse_conducting0.29257624
149MP0001486_abnormal_startle_reflex0.28858671
150MP0002873_normal_phenotype0.28495299
151MP0002169_no_abnormal_phenotype0.28171465
152MP0001661_extended_life_span0.26996779

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.25961077
2Dysautonomia (HP:0002459)6.90493921
3Segmental peripheral demyelination/remyelination (HP:0003481)6.68947510
4Termporal pattern (HP:0011008)6.30319332
5Insidious onset (HP:0003587)6.30319332
6Impaired pain sensation (HP:0007328)6.03016837
7Abnormality of pain sensation (HP:0010832)6.03016837
8Action tremor (HP:0002345)5.27725882
9Type 2 muscle fiber atrophy (HP:0003554)5.18142806
10Pheochromocytoma (HP:0002666)4.97711870
11Aplasia of the musculature (HP:0100854)4.64966557
12Hammertoe (HP:0001765)4.55299586
13Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.53266073
14Neuroendocrine neoplasm (HP:0100634)4.51976031
15Muscle fiber atrophy (HP:0100295)4.41325075
16Steppage gait (HP:0003376)4.29815042
17Muscle hypertrophy of the lower extremities (HP:0008968)4.28127851
18Myokymia (HP:0002411)4.24015961
19Absent/shortened dynein arms (HP:0200106)4.19365975
20Dynein arm defect of respiratory motile cilia (HP:0012255)4.19365975
21Foot dorsiflexor weakness (HP:0009027)4.15605520
22Popliteal pterygium (HP:0009756)4.13555128
23Calf muscle hypertrophy (HP:0008981)4.05489849
24Onion bulb formation (HP:0003383)4.03950802
25Fetal akinesia sequence (HP:0001989)4.02481722
26Abnormal autonomic nervous system physiology (HP:0012332)4.01726658
27Gaze-evoked nystagmus (HP:0000640)3.83079840
28Abnormality of the foot musculature (HP:0001436)3.74139351
29Sudden death (HP:0001699)3.72608298
30Distal arthrogryposis (HP:0005684)3.66653658
31Ankle clonus (HP:0011448)3.55944485
32Abnormal ciliary motility (HP:0012262)3.52898592
33Nonprogressive disorder (HP:0003680)3.50246262
34Abnormality of binocular vision (HP:0011514)3.46123378
35Diplopia (HP:0000651)3.46123378
36Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.43765674
37Supranuclear gaze palsy (HP:0000605)3.36948960
38Impaired proprioception (HP:0010831)3.36086949
39Abnormality of the neuromuscular junction (HP:0003398)3.34767670
40Fatigable weakness (HP:0003473)3.34767670
41Focal seizures (HP:0007359)3.33801815
42True hermaphroditism (HP:0010459)3.31821861
43Failure to thrive in infancy (HP:0001531)3.29105270
44Distal sensory impairment (HP:0002936)3.28115415
45Abnormality of the vocal cords (HP:0008777)3.26644221
46Asymmetric septal hypertrophy (HP:0001670)3.25990753
47Autoamputation (HP:0001218)3.21618706
48Abnormal finger flexion creases (HP:0006143)3.19234475
49Weak cry (HP:0001612)3.16810162
50Congenital sensorineural hearing impairment (HP:0008527)3.14979062
51Thyroid carcinoma (HP:0002890)3.14591188
52Amniotic constriction ring (HP:0009775)3.13430096
53Abnormality of placental membranes (HP:0011409)3.13430096
54Hyporeflexia of lower limbs (HP:0002600)3.12644502
55Decreased motor nerve conduction velocity (HP:0003431)3.12590197
56Palpebral edema (HP:0100540)3.12134900
57Akinesia (HP:0002304)3.08216085
58Attenuation of retinal blood vessels (HP:0007843)3.04993596
59Abnormality of the corticospinal tract (HP:0002492)3.02652550
60Pancreatic cysts (HP:0001737)2.98298635
61Genetic anticipation (HP:0003743)2.97029172
62Late onset (HP:0003584)2.96843878
63Atonic seizures (HP:0010819)2.92996661
64Peripheral hypomyelination (HP:0007182)2.92887356
65Hypercortisolism (HP:0001578)2.92589818
66Abnormal respiratory motile cilium morphology (HP:0005938)2.88052836
67Abnormal respiratory epithelium morphology (HP:0012253)2.88052836
68Myotonia (HP:0002486)2.87854383
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87019361
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.84884293
71Hypothermia (HP:0002045)2.79261454
72Neoplasm of the peripheral nervous system (HP:0100007)2.76404471
73Pancreatic fibrosis (HP:0100732)2.73708317
74Urinary urgency (HP:0000012)2.73388204
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72092192
76Gowers sign (HP:0003391)2.71541406
77Facial shape deformation (HP:0011334)2.71270292
78Potter facies (HP:0002009)2.71270292
79Left ventricular hypertrophy (HP:0001712)2.68756040
80Submucous cleft hard palate (HP:0000176)2.66213240
81Malignant hyperthermia (HP:0002047)2.65657790
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.65272142
83Hypoplasia of the brainstem (HP:0002365)2.65272142
84Postural tremor (HP:0002174)2.64733502
85Tubular atrophy (HP:0000092)2.64030578
86Increased CSF protein (HP:0002922)2.63930012
87Subaortic stenosis (HP:0001682)2.63801273
88Abnormality of the left ventricular outflow tract (HP:0011103)2.63801273
89Abnormality of magnesium homeostasis (HP:0004921)2.63249795
90Thoracolumbar scoliosis (HP:0002944)2.63220630
91Hypomagnesemia (HP:0002917)2.62897055
92Abnormal respiratory motile cilium physiology (HP:0012261)2.60958658
93Keratoconus (HP:0000563)2.57053870
94Increased corneal curvature (HP:0100692)2.57053870
95Exercise-induced muscle cramps (HP:0003710)2.53887487
96Medial flaring of the eyebrow (HP:0010747)2.53124514
97Horizontal nystagmus (HP:0000666)2.53014599
98Abnormality of the calf musculature (HP:0001430)2.51176880
99Peripheral demyelination (HP:0011096)2.48723706
100Facial diplegia (HP:0001349)2.46896544
101Hypoventilation (HP:0002791)2.45158036
102Increased cerebral lipofuscin (HP:0011813)2.44751185
103Ovoid vertebral bodies (HP:0003300)2.43089369
104Gait imbalance (HP:0002141)2.43012748
105Arthropathy (HP:0003040)2.42572254
106Ventricular fibrillation (HP:0001663)2.40580226
107Bradycardia (HP:0001662)2.40249291
108Cerebral hemorrhage (HP:0001342)2.38835089
109Congenital stationary night blindness (HP:0007642)2.36951869
110Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36475807
111Chin dimple (HP:0010751)2.34764112
112Congenital primary aphakia (HP:0007707)2.32726395
113Areflexia of lower limbs (HP:0002522)2.30376982
114Enlarged epiphyses (HP:0010580)2.27683146
115Spastic gait (HP:0002064)2.27288558
116Febrile seizures (HP:0002373)2.27158364
117Clumsiness (HP:0002312)2.26821209
118Nemaline bodies (HP:0003798)2.26792682
119Overlapping toe (HP:0001845)2.25867894
120Cystic liver disease (HP:0006706)2.25294168
121Urinary bladder sphincter dysfunction (HP:0002839)2.21441207
122Bony spicule pigmentary retinopathy (HP:0007737)2.21369628
123Abnormality of calcium-phosphate metabolism (HP:0100530)2.21331716
124Lower limb muscle weakness (HP:0007340)2.20851940
125Progressive cerebellar ataxia (HP:0002073)2.20302618
126Broad ribs (HP:0000885)2.20087279
127Albinism (HP:0001022)2.19690978
128Poor coordination (HP:0002370)2.18971289
129Tubulointerstitial fibrosis (HP:0005576)2.16423462
130Thin ribs (HP:0000883)2.14629873
131Congenital, generalized hypertrichosis (HP:0004540)2.14408424
132Chronic hepatic failure (HP:0100626)2.12795733
133Type II lissencephaly (HP:0007260)2.11161222
134Abnormality of the lower motor neuron (HP:0002366)2.08912180
135Clonus (HP:0002169)2.08690424
136Insomnia (HP:0100785)2.06117198
137Bowel diverticulosis (HP:0005222)2.04437926
138Nephrogenic diabetes insipidus (HP:0009806)2.03587252
139Visual hallucinations (HP:0002367)1.99299812
140Aqueductal stenosis (HP:0002410)1.98505594
141Anosmia (HP:0000458)1.97962559
142Truncal ataxia (HP:0002078)1.97274986
143Hyperkalemia (HP:0002153)1.97203301
144Concave nail (HP:0001598)1.97083749
145Cone-rod dystrophy (HP:0000548)1.96592074
146Round ear (HP:0100830)1.96240234
147Global brain atrophy (HP:0002283)1.95331382
148Mask-like facies (HP:0000298)1.94902105
149Paraplegia (HP:0010550)1.94347338
150Secondary amenorrhea (HP:0000869)1.92324477
151Dialeptic seizures (HP:0011146)1.92122838
152Adducted thumb (HP:0001181)1.91616528
153Rapidly progressive (HP:0003678)1.91240108
154Torticollis (HP:0000473)1.91199684
155Dyschromatopsia (HP:0007641)1.90569538
156Abnormality of the parathyroid morphology (HP:0011766)1.88874456
157Hypoplastic ischia (HP:0003175)1.88453024
158Hypoplastic iliac wings (HP:0002866)1.87327113
159Axonal loss (HP:0003447)1.86989217
160Pes cavus (HP:0001761)1.86416475
161Abnormality of the musculature of the hand (HP:0001421)1.86339120
162Spastic paraplegia (HP:0001258)1.85687427
163Decreased central vision (HP:0007663)1.84980839
164Absent phalangeal crease (HP:0006109)1.84879988
165Limb dystonia (HP:0002451)1.84493641
166Premature ovarian failure (HP:0008209)1.83416668
167Upper limb muscle weakness (HP:0003484)1.83377816
168Neoplasm of the thyroid gland (HP:0100031)1.82404160
169Hand muscle atrophy (HP:0009130)1.82297941
170Generalized tonic-clonic seizures (HP:0002069)1.82007358
171Male pseudohermaphroditism (HP:0000037)1.80975220
172Absence seizures (HP:0002121)1.80448611
173Focal motor seizures (HP:0011153)1.80055659
174Conjunctival telangiectasia (HP:0000524)1.79975327
175Abnormal auditory evoked potentials (HP:0006958)1.79035003
176Neonatal onset (HP:0003623)1.78671779
177Papilledema (HP:0001085)1.78649682
178Easy fatigability (HP:0003388)1.76261827
179Abnormality of the sella turcica (HP:0002679)1.76064983
180Tubulointerstitial abnormality (HP:0001969)1.76048029
181Thyroid-stimulating hormone excess (HP:0002925)1.75735531
182Hypoplasia of the fovea (HP:0007750)1.74271163
183Aplasia/Hypoplasia of the fovea (HP:0008060)1.74271163
184Atrial fibrillation (HP:0005110)1.74100945
185Episodic fever (HP:0001954)1.73392713
186Abnormality of macular pigmentation (HP:0008002)1.73368067
187Palpitations (HP:0001962)1.72463324
188Orthostatic hypotension (HP:0001278)1.70285893
189Genital tract atresia (HP:0001827)1.69929550
190Recurrent corneal erosions (HP:0000495)1.69808894
191Primitive neuroectodermal tumor (HP:0030065)1.69586906
192Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.69586906
193Vaginal atresia (HP:0000148)1.68348364
194Vertebral arch anomaly (HP:0008438)1.66597539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK15.22977720
2PIK3CG4.53447165
3IRAK14.45265918
4KSR24.32203458
5RIPK44.25353550
6MAP3K94.23579615
7LMTK23.69417243
8MAP3K23.30532132
9MATK2.89341467
10OBSCN2.83668270
11MINK12.82461563
12PLK22.80866187
13LIMK12.77309818
14RET2.64653836
15BLK2.56601086
16NTRK32.51200626
17LATS22.41777473
18INSRR2.32075601
19PNCK2.23681817
20GRK52.16409679
21MARK32.14972357
22ARAF2.01547958
23EPHA32.01385878
24TIE11.88042074
25PAK61.82007161
26DDR21.75608858
27ACVR1B1.73432361
28MAP3K121.71213374
29TSSK61.70379792
30BMPR1B1.70256383
31PHKG21.62104060
32PHKG11.62104060
33PDK21.54876195
34MAP3K71.46919732
35MAP3K11.44066635
36MAP2K41.39274376
37MAP2K11.35739589
38STK38L1.31474437
39DAPK21.29071391
40RPS6KA21.25225204
41CDK31.22902355
42MAP3K41.21442232
43FER1.18253166
44WEE11.14852398
45SGK4941.12740201
46SGK2231.12740201
47PRKD31.11494464
48MKNK21.11365127
49MAP2K21.10753688
50PRKG21.06054128
51TAOK31.02604587
52MAPK151.01072929
53NEK11.00505444
54SCYL20.98933063
55EPHB10.97677037
56ADRBK20.97522474
57GRK70.95967084
58GRK10.94674308
59MAP4K20.92463623
60IRAK20.90473150
61CDK50.90015690
62ICK0.89871312
63MAPKAPK30.87701244
64PINK10.87478610
65MAP2K70.85614471
66OXSR10.83686649
67CDK140.83411398
68FGR0.81977482
69FRK0.81228759
70PLK40.80764506
71WNK10.80406369
72FGFR30.80216484
73STK390.77987604
74NEK60.75025864
75PDK10.74928478
76PTK20.73240722
77TEC0.73032880
78SGK20.72252545
79UHMK10.70918302
80RPS6KA40.69845516
81ADRBK10.68050062
82NTRK20.67135436
83CAMKK20.66207287
84KIT0.64776919
85FLT30.64214961
86CDK80.62879325
87WNK40.61805823
88YES10.61403608
89MAPK130.60322361
90FGFR40.60226946
91JAK30.59837920
92PDPK10.59101025
93PRKACB0.56812701
94PRKCG0.55011596
95PRKCZ0.54554055
96CAMK10.53890787
97SGK30.53744458
98PRKCE0.53724311
99CAMK2G0.53180839
100MELK0.52906471
101CAMKK10.52808749
102MAP3K110.52077800
103PRKG10.51721314
104CSNK1G20.51352487
105BRAF0.50224898
106PAK30.49490860
107MET0.49086892
108MAPK70.48683346
109CDC42BPA0.47703804
110MUSK0.47299486
111CAMK1G0.46101646
112CAMK2A0.45782160
113TXK0.44489727
114CAMK40.44293456
115RAF10.43896625
116ERBB20.42557660
117CHUK0.41066502
118MARK10.40025812
119KSR10.39183436
120SYK0.39171977
121DYRK20.38843030
122IKBKB0.38174797
123PTK2B0.35927055
124RPS6KA50.35739764
125MAP2K60.35362760
126ROCK10.35271963
127CAMK1D0.34969007
128JAK20.34059075
129CASK0.33951320
130CDK180.33903799
131CSNK1D0.33829738
132PDK40.33728748
133PDK30.33728748
134LYN0.33002305
135PIK3CA0.32358356
136EGFR0.32175360
137PRKAA10.32086630
138HIPK20.31522670
139MAPK100.31053156
140ROCK20.30861674
141CDK150.30649386
142CLK10.30330569
143MAPKAPK50.30194880
144MAP3K50.29953712
145SRC0.29863672
146CAMK2B0.29436342
147MAP3K130.29255315
148CSNK1G30.28578860
149CSNK1A1L0.28391451
150SGK10.28081225
151IGF1R0.27993264
152PDGFRA0.27910386
153PRKCA0.27631201
154JAK10.27171540
155LRRK20.26977659
156PDGFRB0.26842378
157PRKACA0.26378231
158DAPK10.26076114
159TESK10.26053937
160STK380.25722025
161PRKACG0.25588584
162SIK30.25339715
163MAP3K30.24820080
164CAMK2D0.24131815
165PRKCH0.23405648
166MAPK110.23397152
167PRKAA20.23348371

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.97337877
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.94877168
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.80502027
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.49936266
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.13447545
6Synaptic vesicle cycle_Homo sapiens_hsa047213.00352192
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.94860707
8Thyroid cancer_Homo sapiens_hsa052162.40147926
9Tryptophan metabolism_Homo sapiens_hsa003802.34097096
10Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.16237098
11Butanoate metabolism_Homo sapiens_hsa006502.11208676
12Renin-angiotensin system_Homo sapiens_hsa046142.00888846
13Histidine metabolism_Homo sapiens_hsa003401.98123626
14Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.97754997
15Insulin secretion_Homo sapiens_hsa049111.92918842
16ABC transporters_Homo sapiens_hsa020101.81621193
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81111947
18Dorso-ventral axis formation_Homo sapiens_hsa043201.79391020
19Taste transduction_Homo sapiens_hsa047421.71562432
20Linoleic acid metabolism_Homo sapiens_hsa005911.71225046
21Phototransduction_Homo sapiens_hsa047441.70120232
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69947467
23Dilated cardiomyopathy_Homo sapiens_hsa054141.64676475
24beta-Alanine metabolism_Homo sapiens_hsa004101.62419389
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62181100
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59593157
27Olfactory transduction_Homo sapiens_hsa047401.57774799
28Ether lipid metabolism_Homo sapiens_hsa005651.55749014
29Dopaminergic synapse_Homo sapiens_hsa047281.51056604
30Long-term potentiation_Homo sapiens_hsa047201.47334924
31Fatty acid biosynthesis_Homo sapiens_hsa000611.43526890
32Salivary secretion_Homo sapiens_hsa049701.43256771
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.38180832
34Arachidonic acid metabolism_Homo sapiens_hsa005901.35465291
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35299516
36GnRH signaling pathway_Homo sapiens_hsa049121.34612973
37Cholinergic synapse_Homo sapiens_hsa047251.34565594
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.33971030
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.33346538
40Ovarian steroidogenesis_Homo sapiens_hsa049131.32342936
41Glioma_Homo sapiens_hsa052141.27539331
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26708750
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26056270
44Nitrogen metabolism_Homo sapiens_hsa009101.24666044
45cAMP signaling pathway_Homo sapiens_hsa040241.23525972
46Glutamatergic synapse_Homo sapiens_hsa047241.22444914
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.21703149
48Steroid biosynthesis_Homo sapiens_hsa001001.16810682
49VEGF signaling pathway_Homo sapiens_hsa043701.16026614
50Glycerolipid metabolism_Homo sapiens_hsa005611.15521860
51Circadian entrainment_Homo sapiens_hsa047131.14032237
52Long-term depression_Homo sapiens_hsa047301.12314332
53Estrogen signaling pathway_Homo sapiens_hsa049151.12299348
54Gap junction_Homo sapiens_hsa045401.09870273
55Choline metabolism in cancer_Homo sapiens_hsa052311.08523986
56Insulin signaling pathway_Homo sapiens_hsa049101.08172528
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07400279
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06997241
59Collecting duct acid secretion_Homo sapiens_hsa049661.05269872
60Type II diabetes mellitus_Homo sapiens_hsa049301.04719847
61Salmonella infection_Homo sapiens_hsa051321.04614702
62Glycerophospholipid metabolism_Homo sapiens_hsa005641.03028939
63Cardiac muscle contraction_Homo sapiens_hsa042601.02787215
64Circadian rhythm_Homo sapiens_hsa047101.01854056
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01345509
66Endometrial cancer_Homo sapiens_hsa052131.00684010
67Gastric acid secretion_Homo sapiens_hsa049711.00052356
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.98110246
69Thyroid hormone synthesis_Homo sapiens_hsa049180.97464375
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97183124
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.96693684
72mTOR signaling pathway_Homo sapiens_hsa041500.96637112
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96438572
74Serotonergic synapse_Homo sapiens_hsa047260.95621425
75Melanoma_Homo sapiens_hsa052180.95098702
76Lysine degradation_Homo sapiens_hsa003100.94698108
77Cocaine addiction_Homo sapiens_hsa050300.94298617
78Prolactin signaling pathway_Homo sapiens_hsa049170.92977648
79Bile secretion_Homo sapiens_hsa049760.92079143
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.91864289
81Oocyte meiosis_Homo sapiens_hsa041140.91790186
82Mineral absorption_Homo sapiens_hsa049780.91263032
83Melanogenesis_Homo sapiens_hsa049160.91183828
84Fatty acid degradation_Homo sapiens_hsa000710.90033164
85Pancreatic secretion_Homo sapiens_hsa049720.88100467
86Vibrio cholerae infection_Homo sapiens_hsa051100.87110781
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84785155
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83807943
89ErbB signaling pathway_Homo sapiens_hsa040120.83105146
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.81432024
91Regulation of autophagy_Homo sapiens_hsa041400.81147117
92Endocytosis_Homo sapiens_hsa041440.81012018
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80748245
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79860285
95Morphine addiction_Homo sapiens_hsa050320.78790800
96Calcium signaling pathway_Homo sapiens_hsa040200.78687555
97Glutathione metabolism_Homo sapiens_hsa004800.78387810
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76705984
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76387068
100One carbon pool by folate_Homo sapiens_hsa006700.76335816
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76225340
102Chemical carcinogenesis_Homo sapiens_hsa052040.76148404
103Propanoate metabolism_Homo sapiens_hsa006400.75552943
104GABAergic synapse_Homo sapiens_hsa047270.73169800
105Rap1 signaling pathway_Homo sapiens_hsa040150.72234055
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70133461
107Selenocompound metabolism_Homo sapiens_hsa004500.69760064
108Phagosome_Homo sapiens_hsa041450.66961902
109Oxytocin signaling pathway_Homo sapiens_hsa049210.66247590
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61849629
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60896360
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60752564
113Nicotine addiction_Homo sapiens_hsa050330.60282822
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59856867
115Axon guidance_Homo sapiens_hsa043600.59449644
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58759909
117Fatty acid metabolism_Homo sapiens_hsa012120.58352748
118Renin secretion_Homo sapiens_hsa049240.56480171
119Non-small cell lung cancer_Homo sapiens_hsa052230.55327882
120Retinol metabolism_Homo sapiens_hsa008300.55274356
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52890517
122Prion diseases_Homo sapiens_hsa050200.51765330
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51460313
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48461145
125Amphetamine addiction_Homo sapiens_hsa050310.47131137
126Staphylococcus aureus infection_Homo sapiens_hsa051500.46544233
127Amoebiasis_Homo sapiens_hsa051460.45522394
128PPAR signaling pathway_Homo sapiens_hsa033200.44666567
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44289848
130Ras signaling pathway_Homo sapiens_hsa040140.44274479
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44022168
132Shigellosis_Homo sapiens_hsa051310.43658032
133Starch and sucrose metabolism_Homo sapiens_hsa005000.42776023
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42535751
135Viral myocarditis_Homo sapiens_hsa054160.42213673
136Protein digestion and absorption_Homo sapiens_hsa049740.41203585
137MAPK signaling pathway_Homo sapiens_hsa040100.40487741
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40005950
139Peroxisome_Homo sapiens_hsa041460.39890046
140Bladder cancer_Homo sapiens_hsa052190.38623553
141Platelet activation_Homo sapiens_hsa046110.38144342
142African trypanosomiasis_Homo sapiens_hsa051430.37924381
143Sulfur relay system_Homo sapiens_hsa041220.37464769
144Glucagon signaling pathway_Homo sapiens_hsa049220.36353394
145Hedgehog signaling pathway_Homo sapiens_hsa043400.36104544
146Insulin resistance_Homo sapiens_hsa049310.36103453
147Fatty acid elongation_Homo sapiens_hsa000620.35131193
148Arginine and proline metabolism_Homo sapiens_hsa003300.34105770
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34047479
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33355483
151ECM-receptor interaction_Homo sapiens_hsa045120.33219793
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.29987240
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.27063043
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25890984
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24906780
156Antigen processing and presentation_Homo sapiens_hsa046120.24611039

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