SCN11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)8.05843861
2neurofilament cytoskeleton organization (GO:0060052)7.52962386
3detection of temperature stimulus involved in sensory perception (GO:0050961)7.45807631
4detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.45807631
5detection of temperature stimulus (GO:0016048)7.36966178
6negative regulation of dendrite morphogenesis (GO:0050774)6.91199105
7behavioral response to pain (GO:0048266)6.62783979
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.58500513
9* neuronal action potential (GO:0019228)6.08721997
10peripheral nervous system neuron development (GO:0048935)5.91378413
11response to pain (GO:0048265)5.80463078
12negative regulation of complement activation (GO:0045916)5.80424811
13adenosine metabolic process (GO:0046085)5.76891763
14urinary tract smooth muscle contraction (GO:0014848)5.71819451
15behavioral response to nicotine (GO:0035095)5.65017105
16positive regulation of synaptic transmission, GABAergic (GO:0032230)5.52376120
17fucose catabolic process (GO:0019317)5.21272310
18L-fucose metabolic process (GO:0042354)5.21272310
19L-fucose catabolic process (GO:0042355)5.21272310
20proline transport (GO:0015824)5.16582122
21negative regulation of protein activation cascade (GO:2000258)4.79377008
22positive regulation of muscle hypertrophy (GO:0014742)4.75382586
23positive regulation of cardiac muscle hypertrophy (GO:0010613)4.75382586
24cell communication involved in cardiac conduction (GO:0086065)4.64933380
25cell migration in hindbrain (GO:0021535)4.59243312
26negative regulation of dendrite development (GO:2000171)4.50448767
27potassium ion export (GO:0071435)4.48580728
28phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.41215217
29negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.37443024
30negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.37374999
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.30913402
32enteric nervous system development (GO:0048484)4.30405016
33response to ATP (GO:0033198)4.30217797
34water-soluble vitamin biosynthetic process (GO:0042364)4.28863234
35* membrane depolarization during action potential (GO:0086010)4.28704404
36membrane repolarization (GO:0086009)4.26991480
37regulation of platelet aggregation (GO:0090330)4.24123593
38peristalsis (GO:0030432)4.22114660
39negative regulation of calcium ion transport into cytosol (GO:0010523)4.21813881
40axon cargo transport (GO:0008088)4.17438732
41detection of light stimulus involved in visual perception (GO:0050908)4.09427973
42detection of light stimulus involved in sensory perception (GO:0050962)4.09427973
43negative regulation of homotypic cell-cell adhesion (GO:0034111)3.99366002
44negative regulation of humoral immune response (GO:0002921)3.99201703
45detection of mechanical stimulus involved in sensory perception (GO:0050974)3.96301377
46positive regulation of amino acid transport (GO:0051957)3.93883063
47protein polyglutamylation (GO:0018095)3.92183925
48neuronal action potential propagation (GO:0019227)3.89178345
49negative regulation of microtubule polymerization (GO:0031115)3.89126778
50cellular potassium ion homeostasis (GO:0030007)3.87335716
51DNA deamination (GO:0045006)3.83306956
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81785214
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.80405001
54sodium ion export (GO:0071436)3.77570073
55neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.69556984
56retinal ganglion cell axon guidance (GO:0031290)3.65448079
57epithelial cilium movement (GO:0003351)3.62515258
58indolalkylamine metabolic process (GO:0006586)3.58910813
59response to water (GO:0009415)3.53599580
60glutamate secretion (GO:0014047)3.50024647
61alanine transport (GO:0032328)3.49841360
62synaptic vesicle maturation (GO:0016188)3.48168147
63tryptophan catabolic process (GO:0006569)3.47854062
64indole-containing compound catabolic process (GO:0042436)3.47854062
65indolalkylamine catabolic process (GO:0046218)3.47854062
66acrosome reaction (GO:0007340)3.45684803
67kynurenine metabolic process (GO:0070189)3.42737320
68glycosphingolipid biosynthetic process (GO:0006688)3.42107334
69neuromuscular synaptic transmission (GO:0007274)3.41482151
70establishment of mitochondrion localization (GO:0051654)3.38949451
71piRNA metabolic process (GO:0034587)3.36313311
72cellular response to prostaglandin stimulus (GO:0071379)3.35996166
73kidney morphogenesis (GO:0060993)3.35715903
74* action potential (GO:0001508)3.34294458
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30208676
76regulation of collateral sprouting (GO:0048670)3.29383546
77plasma membrane repair (GO:0001778)3.29264566
78multicellular organismal response to stress (GO:0033555)3.28212639
79intermediate filament organization (GO:0045109)3.27700068
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26763197
81vesicle transport along microtubule (GO:0047496)3.25485384
82adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.23811443
83positive regulation of potassium ion transmembrane transport (GO:1901381)3.22621341
84regulation of membrane depolarization (GO:0003254)3.20991671
85negative regulation of sodium ion transport (GO:0010766)3.19032244
86axoneme assembly (GO:0035082)3.16488801
87fat-soluble vitamin catabolic process (GO:0042363)3.15896599
88vitamin catabolic process (GO:0009111)3.15896599
89intermediate filament-based process (GO:0045103)3.10966577
90regulation of synaptic vesicle exocytosis (GO:2000300)3.10887197
91regulation of amyloid precursor protein catabolic process (GO:1902991)3.10501991
92cellular sodium ion homeostasis (GO:0006883)3.10333149
93ATP synthesis coupled proton transport (GO:0015986)3.10142340
94energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10142340
95preassembly of GPI anchor in ER membrane (GO:0016254)3.08798830
96response to pheromone (GO:0019236)3.08706270
97intermediate filament cytoskeleton organization (GO:0045104)3.06967279
98dopamine receptor signaling pathway (GO:0007212)3.06507704
99innervation (GO:0060384)3.06469064
100regulation of homotypic cell-cell adhesion (GO:0034110)3.05479964
101organelle transport along microtubule (GO:0072384)3.05304062
102regulation of female receptivity (GO:0045924)3.04406761
103cilium movement (GO:0003341)3.02541986
104nonmotile primary cilium assembly (GO:0035058)3.00042542
105platelet dense granule organization (GO:0060155)2.99987456
106* sodium ion transmembrane transport (GO:0035725)2.99586159
107calcium ion-dependent exocytosis (GO:0017156)2.99480442
108protein-cofactor linkage (GO:0018065)2.99468096
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99348086
110negative regulation of protein polymerization (GO:0032272)2.98688640
111protein localization to cilium (GO:0061512)2.97881910
112regulation of cell communication by electrical coupling (GO:0010649)2.97052647
113sensory perception of pain (GO:0019233)2.96739254
114tryptophan metabolic process (GO:0006568)2.95467102
115negative regulation of cation channel activity (GO:2001258)2.94187930
116axon development (GO:0061564)2.93620422
117regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93124349
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92971061
119actin filament capping (GO:0051693)2.92751007
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91511234
121cellular ketone body metabolic process (GO:0046950)2.89999838
122regulation of sodium ion transmembrane transporter activity (GO:2000649)2.89047075
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87148411
124mitochondrion transport along microtubule (GO:0047497)2.87148411
125regulation of mesoderm development (GO:2000380)2.87122773
126glycine transport (GO:0015816)2.86980876
127primary amino compound metabolic process (GO:1901160)2.86855390
128negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.85948319
129negative regulation of actin filament polymerization (GO:0030837)2.85813024
130regulation of cilium movement (GO:0003352)2.84307130
131multicellular organism reproduction (GO:0032504)2.84064928
132positive regulation of fatty acid transport (GO:2000193)2.83630975
133negative regulation of telomere maintenance (GO:0032205)2.82037745
134sensory perception of taste (GO:0050909)2.81642384
135positive regulation of prostaglandin secretion (GO:0032308)2.81390367
136calcium-mediated signaling using intracellular calcium source (GO:0035584)2.80581500
137regulation of early endosome to late endosome transport (GO:2000641)2.78302933
138peptidyl-tyrosine autophosphorylation (GO:0038083)2.78275371
139gamma-aminobutyric acid transport (GO:0015812)2.77975533
140positive regulation of potassium ion transport (GO:0043268)2.77323970
141membrane budding (GO:0006900)2.77253049
142regulation of histone phosphorylation (GO:0033127)2.76642122
143indole-containing compound metabolic process (GO:0042430)2.76559733
144cellular response to ATP (GO:0071318)2.76371578
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.76041839
146cilium morphogenesis (GO:0060271)2.75031212
147positive regulation of cell size (GO:0045793)2.74928611
148cilium organization (GO:0044782)2.72669016
149cilium or flagellum-dependent cell motility (GO:0001539)2.71575635
150protein complex biogenesis (GO:0070271)2.69824506
151negative regulation of T cell differentiation in thymus (GO:0033085)2.68937169
152regulation of action potential (GO:0098900)2.67884611
153female mating behavior (GO:0060180)2.67541856
154transmission of nerve impulse (GO:0019226)2.67185532
155photoreceptor cell maintenance (GO:0045494)2.65830675
156DNA methylation involved in gamete generation (GO:0043046)2.65778423
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64759132
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64759132
159cilium assembly (GO:0042384)2.62533673
160regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58973250
161retinal cone cell development (GO:0046549)2.58080835
162neural tube formation (GO:0001841)2.57100233
163mitochondrial respiratory chain complex assembly (GO:0033108)2.56801652
164NAD biosynthetic process (GO:0009435)2.54612750
165ketone body metabolic process (GO:1902224)2.54018795
166mitochondrial respiratory chain complex I assembly (GO:0032981)2.52573110
167NADH dehydrogenase complex assembly (GO:0010257)2.52573110
168mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52573110
169response to amphetamine (GO:0001975)2.51771240
170S-adenosylmethionine metabolic process (GO:0046500)2.50542884
171somite development (GO:0061053)2.50304277
172axonemal dynein complex assembly (GO:0070286)2.49533934
173fucosylation (GO:0036065)2.48919675
174mannosylation (GO:0097502)2.47296505
175G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46852981
176rhodopsin mediated signaling pathway (GO:0016056)2.45641933
177oxidative demethylation (GO:0070989)2.45543344
178positive regulation of icosanoid secretion (GO:0032305)2.45389017
179reflex (GO:0060004)2.44723822
180serotonin metabolic process (GO:0042428)2.44595640
181respiratory chain complex IV assembly (GO:0008535)2.44116747
182GTP biosynthetic process (GO:0006183)2.43376849
183phosphatidylinositol acyl-chain remodeling (GO:0036149)2.42796385
184DNA demethylation (GO:0080111)2.41126058
185negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.39765497
186organic cation transport (GO:0015695)2.38426537
187positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.38099560
188regulation of meiosis I (GO:0060631)2.37573192
189response to nitrosative stress (GO:0051409)2.37567951
190protein neddylation (GO:0045116)2.36443815
191nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36206211
192behavioral response to ethanol (GO:0048149)2.35997440
193positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.35761378
194sulfation (GO:0051923)2.33977037
195nucleotide transmembrane transport (GO:1901679)2.32621199
196vitamin biosynthetic process (GO:0009110)2.31664121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.15070452
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81744205
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.80696504
4EZH2_22144423_ChIP-Seq_EOC_Human2.76001676
5ZNF263_19887448_ChIP-Seq_K562_Human2.70509902
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69404813
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68708702
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.62560009
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53873838
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.48376089
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.48144929
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40398929
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38753516
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38753516
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38078140
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37626043
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34087126
18GBX2_23144817_ChIP-Seq_PC3_Human2.25485702
19EWS_26573619_Chip-Seq_HEK293_Human2.22838484
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16654656
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15576524
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13845995
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.11905474
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11543466
25* REST_21632747_ChIP-Seq_MESCs_Mouse2.10669723
26FUS_26573619_Chip-Seq_HEK293_Human2.02562488
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98606508
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92704492
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.91837977
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91569137
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.89781576
32TAF15_26573619_Chip-Seq_HEK293_Human1.87079521
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.85056034
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.85006748
35ER_23166858_ChIP-Seq_MCF-7_Human1.84625847
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.81161958
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76417499
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.75518521
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72575090
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.70193056
41EGR1_19032775_ChIP-ChIP_M12_Human1.69315689
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64175271
43TP53_22573176_ChIP-Seq_HFKS_Human1.63680948
44CTCF_27219007_Chip-Seq_Bcells_Human1.62272722
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61178085
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55136072
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54061017
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.52452364
49AHR_22903824_ChIP-Seq_MCF-7_Human1.50518093
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50320184
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48532770
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47925807
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47528856
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45471755
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45339514
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45008720
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44997688
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.42833013
59CBP_20019798_ChIP-Seq_JUKART_Human1.42813618
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42813618
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42319906
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41603519
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40513305
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39664270
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.38145372
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38145372
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38129797
68TCF4_23295773_ChIP-Seq_U87_Human1.37276088
69IRF1_19129219_ChIP-ChIP_H3396_Human1.36807386
70KDM2B_26808549_Chip-Seq_K562_Human1.36492250
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.36315456
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34576502
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34462472
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.34433633
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33463022
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32948898
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31777331
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.31648733
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.31402307
80NCOR_22424771_ChIP-Seq_293T_Human1.30416605
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.29726268
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29227570
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29227570
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29015129
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.28664914
86TCF4_22108803_ChIP-Seq_LS180_Human1.28446163
87MYC_18940864_ChIP-ChIP_HL60_Human1.28264312
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28100439
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.27519744
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.27276736
91ZNF274_21170338_ChIP-Seq_K562_Hela1.26760038
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.26660866
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.25404020
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.24749339
95SMAD4_21741376_ChIP-Seq_HESCs_Human1.24417639
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.22888639
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21879445
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.21460495
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20332942
100RUNX2_22187159_ChIP-Seq_PCA_Human1.19666855
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17758636
102AR_20517297_ChIP-Seq_VCAP_Human1.17237333
103RNF2_27304074_Chip-Seq_NSC_Mouse1.16854934
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16631904
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16364144
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15388300
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15146011
108BCAT_22108803_ChIP-Seq_LS180_Human1.14885786
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.14627653
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14065224
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13845334
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.13477621
113P300_19829295_ChIP-Seq_ESCs_Human1.13253347
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12981240
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12405700
116STAT3_23295773_ChIP-Seq_U87_Human1.12072196
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12061857
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08534186
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.06978776
120SALL1_21062744_ChIP-ChIP_HESCs_Human1.06869781
121HOXB7_26014856_ChIP-Seq_BT474_Human1.06655675
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.06116128
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05862058
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05485991
125IGF1R_20145208_ChIP-Seq_DFB_Human1.05248639
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05071893
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04155264
128DROSHA_22980978_ChIP-Seq_HELA_Human1.03917127
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03341911
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03001087
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.02617593
132GATA1_22025678_ChIP-Seq_K562_Human1.02379447
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.01095213
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00884187
135FOXH1_21741376_ChIP-Seq_EPCs_Human1.00340740
136MYC_19829295_ChIP-Seq_ESCs_Human1.00184069
137ELK1_19687146_ChIP-ChIP_HELA_Human0.99792980
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99662722
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.99488030
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98966173
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98695223
142CDX2_22108803_ChIP-Seq_LS180_Human0.98635621
143ETV1_20927104_ChIP-Seq_GIST48_Human0.98558978
144KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98162760
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97841585
146SOX2_19829295_ChIP-Seq_ESCs_Human0.97491834
147NANOG_19829295_ChIP-Seq_ESCs_Human0.97491834
148AR_19668381_ChIP-Seq_PC3_Human0.96708723
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96250996
150P53_22387025_ChIP-Seq_ESCs_Mouse0.96171114
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.95782817
152AR_25329375_ChIP-Seq_VCAP_Human0.95684495
153AR_21572438_ChIP-Seq_LNCaP_Human0.95300216
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94990192
155PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94585939
156EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93935211
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92067050
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90580037
159KDM2B_26808549_Chip-Seq_REH_Human0.90085536
160RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88803159
161ESR1_21235772_ChIP-Seq_MCF-7_Human0.88276424
162RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88088969
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87930104
164PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.85545077
165UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85328010
166JUN_21703547_ChIP-Seq_K562_Human0.85132499
167P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84865388
168DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83917788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception8.86334649
2* MP0001968_abnormal_touch/_nociception7.57042868
3* MP0002736_abnormal_nociception_after6.51042692
4MP0001986_abnormal_taste_sensitivity5.96536843
5MP0002733_abnormal_thermal_nociception4.96964308
6MP0004270_analgesia4.23648471
7MP0006276_abnormal_autonomic_nervous3.96440810
8MP0004858_abnormal_nervous_system3.94434686
9* MP0002734_abnormal_mechanical_nocicepti3.71884681
10* MP0001970_abnormal_pain_threshold3.67700191
11MP0002653_abnormal_ependyma_morphology3.15708322
12MP0003195_calcinosis2.71139770
13MP0002102_abnormal_ear_morphology2.67100801
14MP0008877_abnormal_DNA_methylation2.55665492
15MP0006292_abnormal_olfactory_placode2.48597713
16MP0005551_abnormal_eye_electrophysiolog2.40342804
17MP0006072_abnormal_retinal_apoptosis2.30613865
18* MP0002272_abnormal_nervous_system2.14398470
19MP0004859_abnormal_synaptic_plasticity2.01993260
20* MP0002067_abnormal_sensory_capabilities1.91710737
21MP0002876_abnormal_thyroid_physiology1.89815567
22MP0002751_abnormal_autonomic_nervous1.88414193
23MP0002184_abnormal_innervation1.84983575
24MP0008875_abnormal_xenobiotic_pharmacok1.84462278
25MP0003656_abnormal_erythrocyte_physiolo1.80187168
26MP0005646_abnormal_pituitary_gland1.79072979
27MP0001501_abnormal_sleep_pattern1.76989569
28MP0004885_abnormal_endolymph1.74024242
29MP0005253_abnormal_eye_physiology1.64832534
30MP0002638_abnormal_pupillary_reflex1.59354352
31MP0003329_amyloid_beta_deposits1.58872658
32MP0005645_abnormal_hypothalamus_physiol1.55413730
33MP0001485_abnormal_pinna_reflex1.55298768
34MP0003635_abnormal_synaptic_transmissio1.54059936
35MP0005083_abnormal_biliary_tract1.50956296
36MP0005377_hearing/vestibular/ear_phenot1.50299800
37MP0003878_abnormal_ear_physiology1.50299800
38MP0004811_abnormal_neuron_physiology1.48664671
39MP0000631_abnormal_neuroendocrine_gland1.47019281
40MP0003787_abnormal_imprinting1.46456246
41MP0003646_muscle_fatigue1.46196204
42MP0001270_distended_abdomen1.46083309
43MP0004043_abnormal_pH_regulation1.40502690
44MP0002234_abnormal_pharynx_morphology1.39345812
45MP0001348_abnormal_lacrimal_gland1.39099832
46MP0003136_yellow_coat_color1.36168105
47MP0008260_abnormal_autophagy1.35394280
48MP0005084_abnormal_gallbladder_morpholo1.32061110
49MP0002928_abnormal_bile_duct1.31182090
50MP0000955_abnormal_spinal_cord1.30457193
51MP0002138_abnormal_hepatobiliary_system1.29065797
52MP0005174_abnormal_tail_pigmentation1.25219830
53MP0001502_abnormal_circadian_rhythm1.21889094
54MP0005423_abnormal_somatic_nervous1.20900665
55MP0008789_abnormal_olfactory_epithelium1.20859132
56MP0003880_abnormal_central_pattern1.19222584
57MP0005389_reproductive_system_phenotype1.18502644
58MP0009046_muscle_twitch1.17628627
59MP0002938_white_spotting1.16584166
60MP0002160_abnormal_reproductive_system1.15229789
61MP0002064_seizures1.12864636
62MP0004133_heterotaxia1.12646297
63MP0003119_abnormal_digestive_system1.12538258
64MP0002277_abnormal_respiratory_mucosa1.11877916
65MP0002063_abnormal_learning/memory/cond1.10636644
66MP0009745_abnormal_behavioral_response1.09813809
67MP0001529_abnormal_vocalization1.09325462
68MP0001919_abnormal_reproductive_system1.09072503
69MP0005671_abnormal_response_to1.08470085
70MP0005410_abnormal_fertilization1.04212568
71MP0003011_delayed_dark_adaptation1.04093392
72MP0005360_urolithiasis1.03860675
73MP0003183_abnormal_peptide_metabolism1.03253086
74MP0003633_abnormal_nervous_system1.01193593
75MP0005499_abnormal_olfactory_system1.01092821
76MP0005394_taste/olfaction_phenotype1.01092821
77MP0005195_abnormal_posterior_eye1.00561124
78MP0000604_amyloidosis0.99404187
79MP0001984_abnormal_olfaction0.98246794
80MP0000372_irregular_coat_pigmentation0.96467111
81MP0002882_abnormal_neuron_morphology0.96191805
82MP0001299_abnormal_eye_distance/0.94105712
83MP0002572_abnormal_emotion/affect_behav0.93676399
84MP0003252_abnormal_bile_duct0.93254841
85MP0001293_anophthalmia0.92891480
86MP0000749_muscle_degeneration0.90873666
87MP0000026_abnormal_inner_ear0.89379815
88MP0005075_abnormal_melanosome_morpholog0.88852686
89MP0003045_fibrosis0.87504378
90MP0009697_abnormal_copulation0.87421253
91MP0005332_abnormal_amino_acid0.86714206
92MP0000747_muscle_weakness0.86337153
93MP0000427_abnormal_hair_cycle0.85229397
94MP0008874_decreased_physiological_sensi0.84607194
95MP0002909_abnormal_adrenal_gland0.84533904
96MP0002693_abnormal_pancreas_physiology0.83459579
97MP0003634_abnormal_glial_cell0.83263454
98* MP0010771_integument_phenotype0.83258890
99MP0000534_abnormal_ureter_morphology0.83214752
100MP0002229_neurodegeneration0.82183100
101MP0002837_dystrophic_cardiac_calcinosis0.81307904
102MP0003698_abnormal_male_reproductive0.80975607
103MP0003718_maternal_effect0.80714232
104MP0000778_abnormal_nervous_system0.80107685
105MP0003890_abnormal_embryonic-extraembry0.79946501
106MP0001929_abnormal_gametogenesis0.77529541
107MP0000920_abnormal_myelination0.77075207
108MP0003631_nervous_system_phenotype0.76745341
109MP0010234_abnormal_vibrissa_follicle0.75130641
110MP0002066_abnormal_motor_capabilities/c0.74529707
111MP0000538_abnormal_urinary_bladder0.73945165
112MP0001440_abnormal_grooming_behavior0.73846550
113MP0004147_increased_porphyrin_level0.68886209
114MP0000751_myopathy0.67824977
115MP0003172_abnormal_lysosome_physiology0.65240528
116MP0004036_abnormal_muscle_relaxation0.64301535
117MP0009379_abnormal_foot_pigmentation0.62706704
118MP0002752_abnormal_somatic_nervous0.62351960
119MP0003868_abnormal_feces_composition0.61766716
120MP0005386_behavior/neurological_phenoty0.58720739
121MP0004924_abnormal_behavior0.58720739
122MP0000569_abnormal_digit_pigmentation0.57793020
123MP0002557_abnormal_social/conspecific_i0.54060007
124MP0010386_abnormal_urinary_bladder0.52969153
125MP0008569_lethality_at_weaning0.52276208
126MP0001905_abnormal_dopamine_level0.52044984
127MP0004130_abnormal_muscle_cell0.51177082
128MP0000579_abnormal_nail_morphology0.50185236
129MP0003806_abnormal_nucleotide_metabolis0.50054219
130MP0002972_abnormal_cardiac_muscle0.49073278
131MP0001664_abnormal_digestion0.48991150
132MP0001486_abnormal_startle_reflex0.48382091
133MP0009780_abnormal_chondrocyte_physiolo0.47953447
134MP0005165_increased_susceptibility_to0.47539774
135MP0004142_abnormal_muscle_tone0.45924150
136MP0004085_abnormal_heartbeat0.45024760
137MP0008961_abnormal_basal_metabolism0.44304754
138MP0005535_abnormal_body_temperature0.43615845
139MP0004145_abnormal_muscle_electrophysio0.42673212
140MP0001756_abnormal_urination0.41382536
141MP0002269_muscular_atrophy0.40688560
142MP0008775_abnormal_heart_ventricle0.40538332
143MP0008872_abnormal_physiological_respon0.39323688
144MP0001661_extended_life_span0.37893520
145MP0003632_abnormal_nervous_system0.35506742
146MP0000681_abnormal_thyroid_gland0.35289336
147MP0004510_myositis0.34619377
148MP0003879_abnormal_hair_cell0.33922630
149MP0000230_abnormal_systemic_arterial0.31796771
150MP0004484_altered_response_of0.31355422
151MP0004084_abnormal_cardiac_muscle0.30929059
152MP0004215_abnormal_myocardial_fiber0.30105248
153MP0004742_abnormal_vestibular_system0.29008367
154MP0000759_abnormal_skeletal_muscle0.28842583
155MP0003283_abnormal_digestive_organ0.28806255
156MP0001963_abnormal_hearing_physiology0.28668652

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.32898399
2Segmental peripheral demyelination/remyelination (HP:0003481)6.67137019
3Insidious onset (HP:0003587)6.42371714
4Termporal pattern (HP:0011008)6.42371714
5Action tremor (HP:0002345)5.35937575
6Pheochromocytoma (HP:0002666)5.25023512
7Myokymia (HP:0002411)5.10032090
8Neuroendocrine neoplasm (HP:0100634)4.76088573
9Hammertoe (HP:0001765)4.63019383
10Steppage gait (HP:0003376)4.38610281
11Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.33712603
12Pancreatic cysts (HP:0001737)4.31904674
13Foot dorsiflexor weakness (HP:0009027)4.31526650
14Dynein arm defect of respiratory motile cilia (HP:0012255)4.07084072
15Absent/shortened dynein arms (HP:0200106)4.07084072
16Onion bulb formation (HP:0003383)4.05319794
17Pancreatic fibrosis (HP:0100732)3.88963885
18Distal arthrogryposis (HP:0005684)3.87241702
19Abnormality of the foot musculature (HP:0001436)3.86571574
20Molar tooth sign on MRI (HP:0002419)3.76841870
21Abnormality of midbrain morphology (HP:0002418)3.76841870
22Ankle clonus (HP:0011448)3.70608595
23Nephronophthisis (HP:0000090)3.65057085
24Focal seizures (HP:0007359)3.64645463
25Congenital stationary night blindness (HP:0007642)3.59398145
26True hermaphroditism (HP:0010459)3.55647806
27Supranuclear gaze palsy (HP:0000605)3.54814223
28Failure to thrive in infancy (HP:0001531)3.47233710
29Type II lissencephaly (HP:0007260)3.42212692
30Abnormality of the renal cortex (HP:0011035)3.40547694
31Atonic seizures (HP:0010819)3.37214670
32* Impaired pain sensation (HP:0007328)3.37081891
33* Abnormality of pain sensation (HP:0010832)3.37081891
34Impaired proprioception (HP:0010831)3.35771140
35Distal sensory impairment (HP:0002936)3.35074814
36Abolished electroretinogram (ERG) (HP:0000550)3.31981548
37Abnormality of the vocal cords (HP:0008777)3.27875850
38Myotonia (HP:0002486)3.23988024
39Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.22521435
40Hypercortisolism (HP:0001578)3.21647786
41Hypothermia (HP:0002045)3.17232859
42Hyporeflexia of lower limbs (HP:0002600)3.15216654
43Abnormal respiratory motile cilium morphology (HP:0005938)3.13476567
44Abnormal respiratory epithelium morphology (HP:0012253)3.13476567
45Abnormality of the renal medulla (HP:0100957)3.10041054
46Tubular atrophy (HP:0000092)3.06390983
47Attenuation of retinal blood vessels (HP:0007843)3.04178727
48Abnormality of the corticospinal tract (HP:0002492)3.02931678
49Decreased motor nerve conduction velocity (HP:0003431)3.00235886
50Medial flaring of the eyebrow (HP:0010747)2.98758076
51Potter facies (HP:0002009)2.95274721
52Facial shape deformation (HP:0011334)2.95274721
53Abnormal ciliary motility (HP:0012262)2.94852420
54Thyroid carcinoma (HP:0002890)2.93161397
55Urinary urgency (HP:0000012)2.93052069
56Hyperventilation (HP:0002883)2.89003665
57Congenital, generalized hypertrichosis (HP:0004540)2.87467776
58Thoracolumbar scoliosis (HP:0002944)2.86262402
59Neoplasm of the peripheral nervous system (HP:0100007)2.85038187
60Submucous cleft hard palate (HP:0000176)2.81289749
61Postural tremor (HP:0002174)2.80369178
62Febrile seizures (HP:0002373)2.75483303
63Keratoconus (HP:0000563)2.74736918
64Increased corneal curvature (HP:0100692)2.74736918
65Autoamputation (HP:0001218)2.74262254
66Hypoventilation (HP:0002791)2.73590830
67Polydipsia (HP:0001959)2.71704802
68Abnormal drinking behavior (HP:0030082)2.71704802
69Pendular nystagmus (HP:0012043)2.68120510
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.66065583
71Increased CSF protein (HP:0002922)2.65937100
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.64621351
73Hypoplasia of the brainstem (HP:0002365)2.64621351
74Renal cortical cysts (HP:0000803)2.63057079
75Abnormality of magnesium homeostasis (HP:0004921)2.60616068
76Cerebral hemorrhage (HP:0001342)2.59478085
77Peripheral hypomyelination (HP:0007182)2.57876658
78Hypomagnesemia (HP:0002917)2.57597094
79Cystic liver disease (HP:0006706)2.53938296
80Progressive cerebellar ataxia (HP:0002073)2.50696340
81Peripheral demyelination (HP:0011096)2.50034436
82Spastic gait (HP:0002064)2.49424840
83Bradycardia (HP:0001662)2.47892238
84Abnormal rod and cone electroretinograms (HP:0008323)2.45628669
85Gait imbalance (HP:0002141)2.44595624
86Bony spicule pigmentary retinopathy (HP:0007737)2.43356310
87Ventricular fibrillation (HP:0001663)2.42667869
88* Dysautonomia (HP:0002459)2.42627659
89Areflexia of lower limbs (HP:0002522)2.42274834
90Abnormal respiratory motile cilium physiology (HP:0012261)2.41934347
91Abnormality of calcium-phosphate metabolism (HP:0100530)2.41188374
92Focal motor seizures (HP:0011153)2.39283585
93Cerebellar dysplasia (HP:0007033)2.38635381
94Chin dimple (HP:0010751)2.36845525
95Decreased central vision (HP:0007663)2.36437466
96Dialeptic seizures (HP:0011146)2.34153499
97Lower limb muscle weakness (HP:0007340)2.31728341
98Chronic hepatic failure (HP:0100626)2.30369195
99Abnormality of alanine metabolism (HP:0010916)2.30163402
100Hyperalaninemia (HP:0003348)2.30163402
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30163402
102Inability to walk (HP:0002540)2.29938782
103Congenital primary aphakia (HP:0007707)2.29263879
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.28758659
105Urinary bladder sphincter dysfunction (HP:0002839)2.27578584
106Increased CSF lactate (HP:0002490)2.21446515
107Overlapping toe (HP:0001845)2.20607300
108Methylmalonic acidemia (HP:0002912)2.20297331
109Absence seizures (HP:0002121)2.19121830
110Visual hallucinations (HP:0002367)2.17993250
111Truncal ataxia (HP:0002078)2.16743739
112Polyuria (HP:0000103)2.15164306
113Thyroiditis (HP:0100646)2.14630006
114Sclerocornea (HP:0000647)2.14209579
115Bowel diverticulosis (HP:0005222)2.12056470
116Clonus (HP:0002169)2.10450858
117Nephrogenic diabetes insipidus (HP:0009806)2.09353056
118Gaze-evoked nystagmus (HP:0000640)2.07932892
119Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07598771
120Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07569389
121Anosmia (HP:0000458)2.07546986
122Congenital hepatic fibrosis (HP:0002612)2.07187207
123Axonal loss (HP:0003447)2.06577459
124Broad-based gait (HP:0002136)2.05502842
125Retinal dysplasia (HP:0007973)2.05280621
126Aqueductal stenosis (HP:0002410)2.04466342
127Furrowed tongue (HP:0000221)2.04436785
128Progressive inability to walk (HP:0002505)2.03871056
129Paraplegia (HP:0010550)2.02780500
130Insomnia (HP:0100785)2.02055388
131Acute necrotizing encephalopathy (HP:0006965)2.02046932
132Torticollis (HP:0000473)2.01523733
133Rapidly progressive (HP:0003678)2.01418687
134Mask-like facies (HP:0000298)2.00896081
135Adducted thumb (HP:0001181)2.00834993
136Lissencephaly (HP:0001339)2.00371287
137Genetic anticipation (HP:0003743)2.00208645
138Chorioretinal atrophy (HP:0000533)2.00079669
139Poor head control (HP:0002421)1.99536100
140Absent phalangeal crease (HP:0006109)1.99208187
141Abnormality of the lower motor neuron (HP:0002366)1.98994773
142Generalized tonic-clonic seizures (HP:0002069)1.98910217
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.98542667
144Hemiparesis (HP:0001269)1.98425868
145Abnormality of the musculature of the hand (HP:0001421)1.98218070
146Postaxial foot polydactyly (HP:0001830)1.97855611
147Decreased circulating renin level (HP:0003351)1.97312730
148Acute encephalopathy (HP:0006846)1.96635175
149Mitochondrial inheritance (HP:0001427)1.96553132
150Neuroblastoma (HP:0003006)1.96200231
151Primitive neuroectodermal tumor (HP:0030065)1.96200231
152Neuroblastic tumors (HP:0004376)1.96200231
153Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.96200231
154Abnormality of the parathyroid morphology (HP:0011766)1.96157805
155Constricted visual fields (HP:0001133)1.95034560
156Progressive microcephaly (HP:0000253)1.95030995
157Short tibia (HP:0005736)1.94908007
158Pes cavus (HP:0001761)1.94637525
159Lower limb asymmetry (HP:0100559)1.94580411
160Large for gestational age (HP:0001520)1.93244318
161Spastic paraplegia (HP:0001258)1.92997012
162Anencephaly (HP:0002323)1.92452639
163Arthropathy (HP:0003040)1.92379081
164Progressive macrocephaly (HP:0004481)1.92177886
165Limb dystonia (HP:0002451)1.92011092
166Hand muscle atrophy (HP:0009130)1.90423766
167Papilledema (HP:0001085)1.89780775
168Male pseudohermaphroditism (HP:0000037)1.89724765
169Aplasia/hypoplasia of the uterus (HP:0008684)1.88048144
170Disproportionate short-trunk short stature (HP:0003521)1.87237753
171Amblyopia (HP:0000646)1.87116627
172Upper limb muscle weakness (HP:0003484)1.85903319
173Fair hair (HP:0002286)1.85123676
174Methylmalonic aciduria (HP:0012120)1.84494228
175Abnormal biliary tract physiology (HP:0012439)1.84119234
176Bile duct proliferation (HP:0001408)1.84119234
177Genital tract atresia (HP:0001827)1.82780027
178Neonatal onset (HP:0003623)1.78802029
179Intestinal atresia (HP:0011100)1.78053435
180Pachygyria (HP:0001302)1.77323974
181Hyperglycinemia (HP:0002154)1.76880630
182Tachypnea (HP:0002789)1.76799968
183Vaginal atresia (HP:0000148)1.76403920
184Craniofacial dystonia (HP:0012179)1.74233585
185Thyroid-stimulating hormone excess (HP:0002925)1.72409239
186Optic disc pallor (HP:0000543)1.72382460
187Morphological abnormality of the pyramidal tract (HP:0002062)1.72021542
188Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70863699
189Abnormal urine output (HP:0012590)1.70748480
190Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70111995
191Retinitis pigmentosa (HP:0000510)1.69784799
192Postaxial hand polydactyly (HP:0001162)1.68724548
193Absent speech (HP:0001344)1.68124609
194Hepatic necrosis (HP:0002605)1.67975465
195Congenital sensorineural hearing impairment (HP:0008527)1.67844545
196Optic nerve hypoplasia (HP:0000609)1.67117906
197Occipital encephalocele (HP:0002085)1.66735360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR24.51898815
2MAP3K94.32519893
3NTRK14.22025520
4RIPK43.98600881
5LMTK23.82706842
6MAP3K23.61880421
7LIMK13.09501507
8MAP4K23.04526027
9MINK12.97262258
10NTRK32.94249367
11WNK32.77763735
12TAOK32.76522174
13ZAK2.75033813
14RET2.73624834
15GRK12.69329105
16NUAK12.59272448
17GRK52.40560529
18BMPR1B2.25743361
19ARAF2.22757424
20LATS22.14365302
21MARK32.10977591
22TXK2.09634215
23MATK2.07423825
24EPHA32.06955209
25TLK12.03910059
26INSRR1.98852558
27MAP3K121.91495044
28ACVR1B1.85973983
29PHKG21.74751083
30PHKG11.74751083
31TIE11.56273548
32PAK61.54883098
33OXSR11.52346617
34MAP3K11.51629614
35MAP2K11.37102212
36TNIK1.34530823
37MAP2K41.28986240
38RPS6KA21.26712189
39PLK21.23742258
40MAP2K21.23163319
41FER1.22829856
42MKNK21.21141708
43DAPK21.20594840
44MST41.19334371
45CSNK1G11.16127623
46SGK4941.14302450
47SGK2231.14302450
48FRK1.12485238
49TRIM281.09955902
50PRKD31.06067086
51NME11.02095739
52WNK11.01028359
53STK390.99072240
54SCYL20.98848061
55MAP3K40.97554956
56FGFR30.95632014
57PRKG20.92848693
58EPHB10.91370248
59NEK10.90350529
60CDK50.88224102
61CDK140.87150673
62BCR0.83148370
63WNK40.82367437
64TGFBR10.78576447
65PNCK0.77894242
66PDK10.76521884
67SGK20.74773889
68STK38L0.74309465
69PINK10.72200097
70MAP2K70.72099212
71PIK3CA0.72025889
72VRK10.71732408
73BCKDK0.70840307
74PTK20.70525057
75TESK10.70361954
76MAPK150.70327559
77PLK40.68582717
78IKBKB0.67614272
79MAPKAPK30.67405870
80MAPK130.67304287
81ERBB30.66621924
82UHMK10.66527097
83ADRBK20.66360461
84FGFR40.65646881
85PRKCI0.65134831
86YES10.64438761
87ADRBK10.63653972
88MKNK10.62503683
89PLK30.62324439
90BRSK20.58070996
91PRKCE0.56855862
92PRKCQ0.56507625
93PDPK10.56253715
94SGK30.56230277
95CAMKK20.55639913
96PRKCZ0.54624627
97CSNK1A10.54390100
98MET0.50851289
99TEC0.50738406
100CHEK20.50671229
101FLT30.50496180
102SIK30.50294705
103CAMKK10.49741873
104PRKCG0.49364272
105MAP4K10.49264757
106CSNK1G20.48042101
107MAP2K60.47491474
108CDC42BPA0.46004035
109VRK20.45875833
110MARK10.45402994
111FGFR20.45172606
112MAPKAPK50.44760735
113GRK70.44453643
114CASK0.43803181
115HIPK20.42561819
116OBSCN0.40698220
117BRAF0.40537292
118MAP3K110.39999645
119RPS6KA50.39719141
120PRKCA0.39625558
121NTRK20.38792057
122IRAK10.38407079
123CAMK2A0.38033704
124ITK0.37987638
125CHUK0.37431035
126KIT0.36574180
127RAF10.35565112
128PLK10.35487772
129ROCK10.35449789
130EPHA40.35208032
131PRKG10.34449710
132JAK20.34191177
133SRC0.33921706
134PTK2B0.32853269
135LRRK20.32839651
136PAK30.32755260
137CDK180.32684115
138MAPK100.32332815
139ROCK20.32069750
140DYRK20.31944168
141NEK90.31839464
142CSNK1D0.30715430
143KSR10.30443642
144CAMK10.30353471
145PIM20.29100448
146PRKACA0.28748284
147JAK10.28530375
148PRKCH0.28459242
149CDK150.28306200
150AKT30.28282109
151DAPK10.28120962
152PRKAA10.27970511
153FYN0.27901633
154SYK0.27705596
155CSNK1G30.27578460
156CAMK2D0.27556687
157CSNK1A1L0.27298002
158IKBKE0.27157997
159IGF1R0.26980198
160PDGFRA0.25889265
161STK380.25585353
162MAP3K130.24974736

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.77242014
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.41011350
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.27656056
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.12617859
5Synaptic vesicle cycle_Homo sapiens_hsa047213.08097131
6Phototransduction_Homo sapiens_hsa047442.86063461
7Nitrogen metabolism_Homo sapiens_hsa009102.47572014
8Linoleic acid metabolism_Homo sapiens_hsa005912.45445479
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33842831
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29989632
11Thyroid cancer_Homo sapiens_hsa052162.22995989
12Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.17679807
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.15536832
14Oxidative phosphorylation_Homo sapiens_hsa001902.15130644
15Butanoate metabolism_Homo sapiens_hsa006502.10207405
16Protein export_Homo sapiens_hsa030602.09923535
17Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.03416239
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01729853
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01514575
20Homologous recombination_Homo sapiens_hsa034401.96217653
21Insulin secretion_Homo sapiens_hsa049111.93974181
22RNA polymerase_Homo sapiens_hsa030201.92534075
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90956063
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89067555
25Dorso-ventral axis formation_Homo sapiens_hsa043201.86631719
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86276117
27Tryptophan metabolism_Homo sapiens_hsa003801.80939936
28Ether lipid metabolism_Homo sapiens_hsa005651.80773547
29Taste transduction_Homo sapiens_hsa047421.80016578
30Olfactory transduction_Homo sapiens_hsa047401.77652166
31Renin-angiotensin system_Homo sapiens_hsa046141.73344530
32Parkinsons disease_Homo sapiens_hsa050121.71186203
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.60929172
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60874534
35Long-term potentiation_Homo sapiens_hsa047201.59460903
36Selenocompound metabolism_Homo sapiens_hsa004501.58318424
37Dopaminergic synapse_Homo sapiens_hsa047281.57171166
38Fanconi anemia pathway_Homo sapiens_hsa034601.56340455
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49956144
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46688384
41Salivary secretion_Homo sapiens_hsa049701.46035210
42Chemical carcinogenesis_Homo sapiens_hsa052041.45381817
43Cholinergic synapse_Homo sapiens_hsa047251.44874650
44Caffeine metabolism_Homo sapiens_hsa002321.41767071
45Sulfur metabolism_Homo sapiens_hsa009201.38180432
46Glutamatergic synapse_Homo sapiens_hsa047241.37915854
47Glioma_Homo sapiens_hsa052141.37113812
48Peroxisome_Homo sapiens_hsa041461.35899100
49Arachidonic acid metabolism_Homo sapiens_hsa005901.33749459
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.33367800
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.31465050
52Circadian entrainment_Homo sapiens_hsa047131.30172399
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29580530
54GnRH signaling pathway_Homo sapiens_hsa049121.28894193
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28500681
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28142272
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.27980078
58Retinol metabolism_Homo sapiens_hsa008301.25334630
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24875465
60Collecting duct acid secretion_Homo sapiens_hsa049661.24793411
61Basal transcription factors_Homo sapiens_hsa030221.24492418
62Central carbon metabolism in cancer_Homo sapiens_hsa052301.24331212
63Propanoate metabolism_Homo sapiens_hsa006401.19370644
64Salmonella infection_Homo sapiens_hsa051321.18980171
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18354461
66Phospholipase D signaling pathway_Homo sapiens_hsa040721.18072840
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17632581
68VEGF signaling pathway_Homo sapiens_hsa043701.16356854
69Long-term depression_Homo sapiens_hsa047301.11585724
70Huntingtons disease_Homo sapiens_hsa050161.11448860
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10018247
72Proteasome_Homo sapiens_hsa030501.09476081
73Gastric acid secretion_Homo sapiens_hsa049711.09117772
74Estrogen signaling pathway_Homo sapiens_hsa049151.08760316
75Serotonergic synapse_Homo sapiens_hsa047261.08659966
76Endometrial cancer_Homo sapiens_hsa052131.07583987
77Cardiac muscle contraction_Homo sapiens_hsa042601.07067704
78Insulin signaling pathway_Homo sapiens_hsa049101.05690526
79Alzheimers disease_Homo sapiens_hsa050101.05594233
80Primary bile acid biosynthesis_Homo sapiens_hsa001201.05409864
81Melanoma_Homo sapiens_hsa052181.05015839
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04854179
83mTOR signaling pathway_Homo sapiens_hsa041501.02613284
84Gap junction_Homo sapiens_hsa045401.02419737
85RNA degradation_Homo sapiens_hsa030181.02246018
86Choline metabolism in cancer_Homo sapiens_hsa052310.99833199
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99483521
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99261799
89ABC transporters_Homo sapiens_hsa020100.97510577
90Thyroid hormone synthesis_Homo sapiens_hsa049180.96803363
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.96034983
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95496524
93Melanogenesis_Homo sapiens_hsa049160.95148540
94Type II diabetes mellitus_Homo sapiens_hsa049300.94740500
95Histidine metabolism_Homo sapiens_hsa003400.94096199
96One carbon pool by folate_Homo sapiens_hsa006700.94045641
97Regulation of autophagy_Homo sapiens_hsa041400.93598949
98Glycerolipid metabolism_Homo sapiens_hsa005610.92785981
99Morphine addiction_Homo sapiens_hsa050320.92360491
100Vibrio cholerae infection_Homo sapiens_hsa051100.91768882
101beta-Alanine metabolism_Homo sapiens_hsa004100.91754901
102Steroid biosynthesis_Homo sapiens_hsa001000.90622834
103Prolactin signaling pathway_Homo sapiens_hsa049170.90049552
104Bile secretion_Homo sapiens_hsa049760.88708731
105GABAergic synapse_Homo sapiens_hsa047270.88479832
106Mineral absorption_Homo sapiens_hsa049780.88476758
107Asthma_Homo sapiens_hsa053100.88401619
108Pancreatic secretion_Homo sapiens_hsa049720.87978474
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.86397057
110Oocyte meiosis_Homo sapiens_hsa041140.86186573
111ErbB signaling pathway_Homo sapiens_hsa040120.86027235
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84849348
113Purine metabolism_Homo sapiens_hsa002300.83918766
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.81862267
115Endocytosis_Homo sapiens_hsa041440.81536921
116Calcium signaling pathway_Homo sapiens_hsa040200.80224724
117Primary immunodeficiency_Homo sapiens_hsa053400.79126231
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78928446
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78479895
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78260274
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76466521
122Phagosome_Homo sapiens_hsa041450.75639023
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73401588
124Nicotine addiction_Homo sapiens_hsa050330.72992691
125Rap1 signaling pathway_Homo sapiens_hsa040150.72543541
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72243664
127Oxytocin signaling pathway_Homo sapiens_hsa049210.71856540
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71107352
129Renin secretion_Homo sapiens_hsa049240.70346391
130Fat digestion and absorption_Homo sapiens_hsa049750.70143308
131Metabolic pathways_Homo sapiens_hsa011000.70068177
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69084917
133Type I diabetes mellitus_Homo sapiens_hsa049400.66526280
134Axon guidance_Homo sapiens_hsa043600.64187222
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63691166
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61083978
137Non-small cell lung cancer_Homo sapiens_hsa052230.60927888
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59368742
139Ovarian steroidogenesis_Homo sapiens_hsa049130.57954670
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56052976
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56030261
142Pyrimidine metabolism_Homo sapiens_hsa002400.55688530
143Prion diseases_Homo sapiens_hsa050200.52011057
144Amphetamine addiction_Homo sapiens_hsa050310.52009810
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51781944
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.50612233
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49954086
148Ras signaling pathway_Homo sapiens_hsa040140.47318734
149Allograft rejection_Homo sapiens_hsa053300.46690962
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46518025
151Shigellosis_Homo sapiens_hsa051310.45426780
152Fatty acid degradation_Homo sapiens_hsa000710.44364419
153Amoebiasis_Homo sapiens_hsa051460.43396911
154Circadian rhythm_Homo sapiens_hsa047100.43240460
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.42541978
156Non-homologous end-joining_Homo sapiens_hsa034500.42340954
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41815258
158Starch and sucrose metabolism_Homo sapiens_hsa005000.41768767
159AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41737777
160MAPK signaling pathway_Homo sapiens_hsa040100.39583884
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39243431
162African trypanosomiasis_Homo sapiens_hsa051430.39143461
163Protein digestion and absorption_Homo sapiens_hsa049740.38444375
164Bladder cancer_Homo sapiens_hsa052190.38380379
165Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38150872
166cAMP signaling pathway_Homo sapiens_hsa040240.37242724
167Sulfur relay system_Homo sapiens_hsa041220.37198478
168Autoimmune thyroid disease_Homo sapiens_hsa053200.36530137
169Glucagon signaling pathway_Homo sapiens_hsa049220.36041425
170Cocaine addiction_Homo sapiens_hsa050300.35739518
171Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33954313
172Glutathione metabolism_Homo sapiens_hsa004800.33621184
173Graft-versus-host disease_Homo sapiens_hsa053320.33324180
174Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31248566
175Hedgehog signaling pathway_Homo sapiens_hsa043400.30828446

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