SCN3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72456013
2vocalization behavior (GO:0071625)5.46432491
3neuron cell-cell adhesion (GO:0007158)5.28849593
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24763846
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22566868
6locomotory exploration behavior (GO:0035641)5.19039426
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.16285261
8synaptic vesicle maturation (GO:0016188)5.11643274
9synaptic vesicle exocytosis (GO:0016079)5.05115965
10regulation of glutamate receptor signaling pathway (GO:1900449)4.93164753
11protein localization to synapse (GO:0035418)4.91449764
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.69234238
13glutamate secretion (GO:0014047)4.65312214
14exploration behavior (GO:0035640)4.58399075
15regulation of synaptic vesicle exocytosis (GO:2000300)4.58102593
16dendritic spine morphogenesis (GO:0060997)4.54820650
17neuron recognition (GO:0008038)4.49168634
18regulation of synapse structural plasticity (GO:0051823)4.47312284
19* membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.44921393
20axonal fasciculation (GO:0007413)4.43200679
21regulation of neuronal synaptic plasticity (GO:0048168)4.37198770
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.34881350
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.25761075
24layer formation in cerebral cortex (GO:0021819)4.21967315
25regulation of synaptic vesicle transport (GO:1902803)4.16003203
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.14775655
27glutamate receptor signaling pathway (GO:0007215)4.12258923
28synaptic transmission, glutamatergic (GO:0035249)4.12033221
29neurotransmitter secretion (GO:0007269)4.00178041
30neuronal action potential propagation (GO:0019227)3.99099738
31presynaptic membrane organization (GO:0097090)3.95418392
32neurotransmitter-gated ion channel clustering (GO:0072578)3.94514258
33neuron-neuron synaptic transmission (GO:0007270)3.89452112
34positive regulation of synapse maturation (GO:0090129)3.76512630
35proline transport (GO:0015824)3.75907658
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70068359
37long-term memory (GO:0007616)3.66164929
38* membrane depolarization during action potential (GO:0086010)3.61475298
39startle response (GO:0001964)3.61190606
40neuromuscular synaptic transmission (GO:0007274)3.59997359
41cell migration in hindbrain (GO:0021535)3.55601321
42sodium ion export (GO:0071436)3.55446142
43innervation (GO:0060384)3.54388551
44regulation of postsynaptic membrane potential (GO:0060078)3.52520860
45regulation of synaptic plasticity (GO:0048167)3.52158244
46dendrite morphogenesis (GO:0048813)3.50191629
47establishment of mitochondrion localization (GO:0051654)3.49094528
48regulation of dendritic spine morphogenesis (GO:0061001)3.48852663
49synaptic vesicle endocytosis (GO:0048488)3.47958421
50behavioral response to nicotine (GO:0035095)3.46476138
51postsynaptic membrane organization (GO:0001941)3.44590398
52positive regulation of membrane potential (GO:0045838)3.44115831
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.39427017
54dendritic spine organization (GO:0097061)3.39336541
55central nervous system projection neuron axonogenesis (GO:0021952)3.36933931
56transmission of nerve impulse (GO:0019226)3.36591089
57pyrimidine nucleobase catabolic process (GO:0006208)3.36090274
58mating behavior (GO:0007617)3.34216760
59negative regulation of microtubule polymerization (GO:0031115)3.33356916
60behavioral fear response (GO:0001662)3.30592068
61behavioral defense response (GO:0002209)3.30592068
62cerebellar Purkinje cell differentiation (GO:0021702)3.29284894
63long-term synaptic potentiation (GO:0060291)3.28797659
64neurotransmitter transport (GO:0006836)3.27297989
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26233406
66neuronal ion channel clustering (GO:0045161)3.25627644
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25521655
68synapse assembly (GO:0007416)3.25242950
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24926078
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24680089
71regulation of voltage-gated calcium channel activity (GO:1901385)3.23631310
72regulation of vesicle fusion (GO:0031338)3.21825581
73auditory behavior (GO:0031223)3.20866262
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.19845400
75response to pheromone (GO:0019236)3.19053214
76gamma-aminobutyric acid transport (GO:0015812)3.19028173
77cerebellar granule cell differentiation (GO:0021707)3.18457270
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16271127
79mechanosensory behavior (GO:0007638)3.15416420
80positive regulation of neurotransmitter secretion (GO:0001956)3.14531041
81regulation of neurotransmitter secretion (GO:0046928)3.13140059
82activation of protein kinase A activity (GO:0034199)3.13096357
83learning (GO:0007612)3.12674291
84potassium ion homeostasis (GO:0055075)3.12415678
85prepulse inhibition (GO:0060134)3.12003736
86adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.11352492
87positive regulation of dendritic spine development (GO:0060999)3.10909416
88fear response (GO:0042596)3.10683871
89neuromuscular process controlling balance (GO:0050885)3.10482553
90regulation of neurotransmitter levels (GO:0001505)3.10131448
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09174737
92response to auditory stimulus (GO:0010996)3.08470377
93adult walking behavior (GO:0007628)3.06931953
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06402647
95dopamine receptor signaling pathway (GO:0007212)3.06235995
96regulation of synapse maturation (GO:0090128)3.04501299
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.04420444
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04283599
99positive regulation of neurotransmitter transport (GO:0051590)3.03743978
100positive regulation of dendritic spine morphogenesis (GO:0061003)3.03601090
101positive regulation of synapse assembly (GO:0051965)3.03125146
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01517735
103* membrane depolarization (GO:0051899)3.01396333
104regulation of dendritic spine development (GO:0060998)2.98736833
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97853619
106response to histamine (GO:0034776)2.97578339
107potassium ion import (GO:0010107)2.97528484
108presynaptic membrane assembly (GO:0097105)2.97102177
109cellular potassium ion homeostasis (GO:0030007)2.95868142
110nucleobase catabolic process (GO:0046113)2.95671843
111L-amino acid import (GO:0043092)2.95031766
112intraspecies interaction between organisms (GO:0051703)2.94090123
113social behavior (GO:0035176)2.94090123
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.92480401
115mitochondrion transport along microtubule (GO:0047497)2.92480401
116dendrite development (GO:0016358)2.91242779
117axon extension (GO:0048675)2.91017559
118vesicle transport along microtubule (GO:0047496)2.90494327
119regulation of neurotransmitter transport (GO:0051588)2.90439138
120regulation of synaptic transmission (GO:0050804)2.88440697
121cell communication by electrical coupling (GO:0010644)2.87983967
122serotonin metabolic process (GO:0042428)2.87767964
123synaptic transmission (GO:0007268)2.86643186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.73422850
2GBX2_23144817_ChIP-Seq_PC3_Human3.72948934
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17834180
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09690893
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99303651
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75372493
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75372493
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69594322
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69537661
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.68505833
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.66832544
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60833151
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48162451
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47448609
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45049383
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.39613423
17* RARB_27405468_Chip-Seq_BRAIN_Mouse2.36229891
18DROSHA_22980978_ChIP-Seq_HELA_Human2.35501510
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29661203
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.26956616
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26551001
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.25969666
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24881032
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18391685
25TAF15_26573619_Chip-Seq_HEK293_Human2.03130019
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92637419
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90792684
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82358012
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81739344
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76050268
31AR_21572438_ChIP-Seq_LNCaP_Human1.74177012
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69512645
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64204876
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63690666
35SMAD4_21799915_ChIP-Seq_A2780_Human1.62694896
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60766210
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60027775
38ZNF274_21170338_ChIP-Seq_K562_Hela1.57242877
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56002874
40P300_19829295_ChIP-Seq_ESCs_Human1.51827068
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.49750877
42IGF1R_20145208_ChIP-Seq_DFB_Human1.48485984
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.45968365
44* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44996744
45* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44688642
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43813099
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.39722709
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.32324775
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31338464
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30214512
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.29692029
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26299907
53RNF2_27304074_Chip-Seq_NSC_Mouse1.25428113
54AR_25329375_ChIP-Seq_VCAP_Human1.24488363
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20802442
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19797417
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.18936502
58AR_19668381_ChIP-Seq_PC3_Human1.16217311
59STAT3_23295773_ChIP-Seq_U87_Human1.15714338
60VDR_22108803_ChIP-Seq_LS180_Human1.15425748
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15287424
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.15107141
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.12690220
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12034605
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11976054
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11840468
67AHR_22903824_ChIP-Seq_MCF-7_Human1.11008205
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10280277
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09611338
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07886084
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07749605
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06671056
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05573862
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05525264
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04101352
76RUNX2_22187159_ChIP-Seq_PCA_Human1.03634048
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03184649
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01937359
79TCF4_23295773_ChIP-Seq_U87_Human1.01520359
80JUN_21703547_ChIP-Seq_K562_Human1.01476780
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.00534760
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00224074
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99259405
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98803396
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98640046
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97698231
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.96923221
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96699792
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96699792
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96554666
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96256495
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95090669
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.93984758
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.93651135
95GATA1_26923725_Chip-Seq_HPCs_Mouse0.93627848
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93223166
97KDM2B_26808549_Chip-Seq_K562_Human0.92977981
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92538429
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.92504874
100FUS_26573619_Chip-Seq_HEK293_Human0.92340035
101TP53_18474530_ChIP-ChIP_U2OS_Human0.91837188
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91225091
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90183721
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90093194
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89823538
106CBP_20019798_ChIP-Seq_JUKART_Human0.89823538
107BCAT_22108803_ChIP-Seq_LS180_Human0.89740579
108* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89683251
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88962501
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88624432
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88267679
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88145671
113KDM2B_26808549_Chip-Seq_REH_Human0.86096209
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85657859
115* CTCF_27219007_Chip-Seq_Bcells_Human0.84863336
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83770419
117FLI1_21867929_ChIP-Seq_TH2_Mouse0.83697531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.50161890
2MP0003880_abnormal_central_pattern5.31362221
3MP0003635_abnormal_synaptic_transmissio4.07567088
4MP0004270_analgesia3.92392616
5MP0002063_abnormal_learning/memory/cond3.42155989
6MP0009745_abnormal_behavioral_response3.18977573
7MP0001968_abnormal_touch/_nociception2.96060870
8MP0002822_catalepsy2.95187708
9MP0002064_seizures2.86046541
10MP0005423_abnormal_somatic_nervous2.83486747
11MP0002572_abnormal_emotion/affect_behav2.73408558
12MP0006276_abnormal_autonomic_nervous2.62984632
13MP0002734_abnormal_mechanical_nocicepti2.61680420
14MP0002735_abnormal_chemical_nociception2.40577104
15MP0009046_muscle_twitch2.31950094
16MP0002272_abnormal_nervous_system2.31556659
17MP0002736_abnormal_nociception_after2.30184793
18MP0000778_abnormal_nervous_system2.28847639
19MP0001486_abnormal_startle_reflex2.28422301
20MP0001501_abnormal_sleep_pattern2.23725925
21MP0002733_abnormal_thermal_nociception2.15934988
22MP0002184_abnormal_innervation2.15192226
23MP0001440_abnormal_grooming_behavior2.14447640
24MP0001984_abnormal_olfaction2.03640042
25MP0001970_abnormal_pain_threshold1.98647369
26MP0005645_abnormal_hypothalamus_physiol1.92090608
27MP0004858_abnormal_nervous_system1.90434110
28MP0002557_abnormal_social/conspecific_i1.89065993
29MP0004811_abnormal_neuron_physiology1.84178711
30MP0002067_abnormal_sensory_capabilities1.84107085
31MP0001529_abnormal_vocalization1.78278863
32MP0002909_abnormal_adrenal_gland1.70553629
33MP0003329_amyloid_beta_deposits1.69937662
34MP0004924_abnormal_behavior1.68774224
35MP0005386_behavior/neurological_phenoty1.68774224
36MP0003122_maternal_imprinting1.68069060
37MP0009780_abnormal_chondrocyte_physiolo1.62113829
38MP0005646_abnormal_pituitary_gland1.59922608
39MP0000955_abnormal_spinal_cord1.59831578
40MP0001905_abnormal_dopamine_level1.56276665
41MP0008569_lethality_at_weaning1.49102238
42MP0002882_abnormal_neuron_morphology1.48397052
43MP0001188_hyperpigmentation1.45629386
44MP0003787_abnormal_imprinting1.39020146
45MP0002066_abnormal_motor_capabilities/c1.36289712
46MP0008877_abnormal_DNA_methylation1.32887628
47MP0001502_abnormal_circadian_rhythm1.32784459
48MP0005394_taste/olfaction_phenotype1.31294141
49MP0005499_abnormal_olfactory_system1.31294141
50MP0000569_abnormal_digit_pigmentation1.21421769
51MP0003123_paternal_imprinting1.19938724
52MP0002152_abnormal_brain_morphology1.18353037
53MP0003879_abnormal_hair_cell1.18227930
54MP0001986_abnormal_taste_sensitivity1.15742630
55MP0004885_abnormal_endolymph1.11723688
56MP0010386_abnormal_urinary_bladder1.10865002
57MP0003633_abnormal_nervous_system1.06554436
58MP0000751_myopathy1.03753725
59MP0004742_abnormal_vestibular_system1.00491748
60MP0002069_abnormal_eating/drinking_beha0.97225442
61MP0003631_nervous_system_phenotype0.94773687
62MP0004142_abnormal_muscle_tone0.94471471
63MP0002102_abnormal_ear_morphology0.93113495
64MP0001485_abnormal_pinna_reflex0.92756851
65MP0008872_abnormal_physiological_respon0.92721237
66MP0000631_abnormal_neuroendocrine_gland0.91859515
67MP0003690_abnormal_glial_cell0.91650854
68MP0002638_abnormal_pupillary_reflex0.88726175
69MP0005409_darkened_coat_color0.87670919
70MP0002752_abnormal_somatic_nervous0.84601250
71MP0008789_abnormal_olfactory_epithelium0.84573622
72MP0002837_dystrophic_cardiac_calcinosis0.84109883
73MP0000920_abnormal_myelination0.83697410
74MP0002751_abnormal_autonomic_nervous0.82015171
75MP0004085_abnormal_heartbeat0.80482638
76MP0003634_abnormal_glial_cell0.80008336
77MP0001177_atelectasis0.79279145
78MP0005535_abnormal_body_temperature0.78447901
79MP0004133_heterotaxia0.78354750
80MP0002229_neurodegeneration0.77357616
81MP0003861_abnormal_nervous_system0.76157033
82MP0008874_decreased_physiological_sensi0.75990249
83MP0001963_abnormal_hearing_physiology0.74593332
84MP0004130_abnormal_muscle_cell0.72269314
85MP0005551_abnormal_eye_electrophysiolog0.71654655
86MP0004147_increased_porphyrin_level0.71023952
87MP0004145_abnormal_muscle_electrophysio0.68201092
88MP0004043_abnormal_pH_regulation0.67801125
89MP0005253_abnormal_eye_physiology0.66772247
90MP0000604_amyloidosis0.65751118
91MP0003632_abnormal_nervous_system0.65034476
92MP0001664_abnormal_digestion0.64864675
93MP0008961_abnormal_basal_metabolism0.63985132
94MP0003121_genomic_imprinting0.63601048
95MP0002653_abnormal_ependyma_morphology0.63484522
96MP0003137_abnormal_impulse_conducting0.63404297
97MP0003283_abnormal_digestive_organ0.57392229
98MP0000534_abnormal_ureter_morphology0.57260882
99MP0001943_abnormal_respiration0.57125495
100MP0005187_abnormal_penis_morphology0.57050897
101MP0001299_abnormal_eye_distance/0.56835650
102MP0004233_abnormal_muscle_weight0.55660544
103MP0000026_abnormal_inner_ear0.54423566
104MP0002234_abnormal_pharynx_morphology0.54332695
105MP0006072_abnormal_retinal_apoptosis0.53722575
106MP0002082_postnatal_lethality0.52913584
107MP0010770_preweaning_lethality0.52913584
108MP0003075_altered_response_to0.52850522
109MP0010769_abnormal_survival0.52393672
110MP0004215_abnormal_myocardial_fiber0.51881366
111MP0004484_altered_response_of0.51641167
112MP0002876_abnormal_thyroid_physiology0.51574074
113MP0010768_mortality/aging0.49184217

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.17420544
2Myokymia (HP:0002411)6.89283471
3Focal seizures (HP:0007359)5.68115029
4Visual hallucinations (HP:0002367)4.80289818
5Epileptic encephalopathy (HP:0200134)4.32233850
6Progressive cerebellar ataxia (HP:0002073)4.08856799
7Limb dystonia (HP:0002451)4.00998880
8Febrile seizures (HP:0002373)3.99761974
9Atonic seizures (HP:0010819)3.88537275
10Absence seizures (HP:0002121)3.69029997
11Supranuclear gaze palsy (HP:0000605)3.65901909
12Action tremor (HP:0002345)3.60995198
13Generalized tonic-clonic seizures (HP:0002069)3.49302153
14Dialeptic seizures (HP:0011146)3.47557830
15Amblyopia (HP:0000646)3.42860626
16Broad-based gait (HP:0002136)3.39117643
17Ankle clonus (HP:0011448)3.35231262
18Mutism (HP:0002300)3.32042776
19Hyperventilation (HP:0002883)3.25777082
20Drooling (HP:0002307)3.18557982
21Excessive salivation (HP:0003781)3.18557982
22Poor eye contact (HP:0000817)3.03898730
23Abnormal eating behavior (HP:0100738)2.98613786
24Polyphagia (HP:0002591)2.98460364
25Papilledema (HP:0001085)2.97057455
26Depression (HP:0000716)2.95810636
27Cerebral inclusion bodies (HP:0100314)2.93024179
28Truncal ataxia (HP:0002078)2.87597603
29Impaired vibration sensation in the lower limbs (HP:0002166)2.86373385
30Anxiety (HP:0000739)2.81044630
31Status epilepticus (HP:0002133)2.80571047
32Neurofibrillary tangles (HP:0002185)2.76778605
33Abnormal social behavior (HP:0012433)2.73106799
34Impaired social interactions (HP:0000735)2.73106799
35Torticollis (HP:0000473)2.72699123
36Progressive inability to walk (HP:0002505)2.67490935
37Dysmetria (HP:0001310)2.63939752
38Focal dystonia (HP:0004373)2.55060719
39Failure to thrive in infancy (HP:0001531)2.52962510
40Genetic anticipation (HP:0003743)2.51152769
41Urinary bladder sphincter dysfunction (HP:0002839)2.51046784
42Insidious onset (HP:0003587)2.50076759
43Termporal pattern (HP:0011008)2.50076759
44Dysdiadochokinesis (HP:0002075)2.49947431
45Hemiparesis (HP:0001269)2.49052779
46Urinary urgency (HP:0000012)2.48812368
47Amyotrophic lateral sclerosis (HP:0007354)2.44437381
48Postural instability (HP:0002172)2.43863306
49Abnormality of the lower motor neuron (HP:0002366)2.42408095
50Hemiplegia (HP:0002301)2.41464849
51Epileptiform EEG discharges (HP:0011182)2.41386673
52Cerebral hypomyelination (HP:0006808)2.41287707
53Gaze-evoked nystagmus (HP:0000640)2.39487388
54Absent speech (HP:0001344)2.37993412
55Impaired smooth pursuit (HP:0007772)2.36121404
56Exotropia (HP:0000577)2.33443840
57Bradykinesia (HP:0002067)2.33395556
58Fetal akinesia sequence (HP:0001989)2.32358022
59Stereotypic behavior (HP:0000733)2.30553391
60Craniofacial dystonia (HP:0012179)2.30404188
61Agitation (HP:0000713)2.30142726
62Morphological abnormality of the pyramidal tract (HP:0002062)2.29258491
63Aplasia/Hypoplasia of the brainstem (HP:0007362)2.28224393
64Hypoplasia of the brainstem (HP:0002365)2.28224393
65Spastic tetraplegia (HP:0002510)2.26356623
66Pheochromocytoma (HP:0002666)2.25414901
67Inability to walk (HP:0002540)2.24912993
68EEG with generalized epileptiform discharges (HP:0011198)2.24491406
69Spastic gait (HP:0002064)2.24469815
70Abnormality of binocular vision (HP:0011514)2.23447021
71Diplopia (HP:0000651)2.23447021
72Abnormality of salivation (HP:0100755)2.20932311
73Gait imbalance (HP:0002141)2.19122730
74Hypsarrhythmia (HP:0002521)2.13814458
75Hypoventilation (HP:0002791)2.11218723
76Lower limb muscle weakness (HP:0007340)2.11034878
77Specific learning disability (HP:0001328)2.07665820
78Inappropriate behavior (HP:0000719)2.05773559
79Abnormality of the corticospinal tract (HP:0002492)2.04653369
80Megalencephaly (HP:0001355)2.04243891
81Pachygyria (HP:0001302)2.03059993
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02099201
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.02099201
84Akinesia (HP:0002304)2.00472393
85Blue irides (HP:0000635)2.00133032
86Prolonged QT interval (HP:0001657)1.99529488
87Abnormality of ocular smooth pursuit (HP:0000617)1.99319277
88Scanning speech (HP:0002168)1.97173389
89Insomnia (HP:0100785)1.96815658
90Spastic tetraparesis (HP:0001285)1.93630164
91Protruding tongue (HP:0010808)1.92930766
92Sleep apnea (HP:0010535)1.91699195
93Apathy (HP:0000741)1.91541049
94Incomplete penetrance (HP:0003829)1.90580753
95Muscular hypotonia of the trunk (HP:0008936)1.90193210
96Abnormality of the labia minora (HP:0012880)1.90127364
97Impaired vibratory sensation (HP:0002495)1.90008429
98Anosmia (HP:0000458)1.88846600
99Neuroendocrine neoplasm (HP:0100634)1.85621308
100Lissencephaly (HP:0001339)1.85142108
101Poor suck (HP:0002033)1.84878704
102Intellectual disability, severe (HP:0010864)1.84861764
103Pointed chin (HP:0000307)1.83807996
104Rapidly progressive (HP:0003678)1.83733445
105Hypoplasia of the corpus callosum (HP:0002079)1.83707362
106Clonus (HP:0002169)1.83207582
107Intention tremor (HP:0002080)1.81322064
108Congenital stationary night blindness (HP:0007642)1.78468170
109Esotropia (HP:0000565)1.77601619
110Gait ataxia (HP:0002066)1.77266994
111Ventricular fibrillation (HP:0001663)1.77010288
112Type II lissencephaly (HP:0007260)1.76539596
113Autism (HP:0000717)1.75272162
114Delusions (HP:0000746)1.75002978
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74985097
116Syncope (HP:0001279)1.74405851
117Abnormality of pain sensation (HP:0010832)1.74331509
118Impaired pain sensation (HP:0007328)1.74331509
119Nephronophthisis (HP:0000090)1.73483026
120Generalized myoclonic seizures (HP:0002123)1.72208260
121Dyskinesia (HP:0100660)1.69909643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.50093399
2NTRK34.39153105
3EPHA44.12408307
4MAP3K93.52604661
5MINK13.03388937
6MAP3K42.81786993
7NTRK22.70344544
8KSR12.50515939
9MAP2K72.46681703
10NTRK12.40860311
11DAPK22.25351038
12SIK32.16737760
13MAP3K121.98606284
14PAK61.91982680
15KSR21.82314935
16RIPK41.82239666
17MAPK131.74250130
18CASK1.73397553
19MAP2K41.73319121
20DAPK11.60141078
21CDK51.57854126
22SIK21.53545956
23PRPF4B1.42772790
24GRK51.42282232
25PRKD31.41689728
26UHMK11.39526887
27TNIK1.36518686
28PLK21.35247691
29FRK1.34405700
30PHKG21.29660282
31PHKG11.29660282
32ARAF1.24324559
33CAMKK11.24182027
34PNCK1.22863278
35BCR1.17333282
36PRKCG1.14367307
37WNK31.13785857
38LATS21.07302123
39CDK181.06192969
40FES1.04571256
41CAMK2A1.04251934
42CAMK2B1.01698779
43TYRO30.96493860
44PTK2B0.95149073
45CDK150.94623473
46PKN10.93870466
47CDK140.93586504
48CSNK1G20.92440503
49MAP3K20.90888929
50EPHB20.90138335
51MAP4K20.89505472
52SGK4940.84834464
53SGK2230.84834464
54STK380.84051759
55CDK11A0.82171982
56PAK30.81467449
57MAPK120.81409024
58BMPR20.80375264
59RET0.80232692
60ADRBK20.78641732
61DYRK1A0.78344704
62SGK20.71627296
63ERBB30.70677382
64RAF10.69014621
65DYRK20.68339108
66NME10.67843293
67CAMK40.67499824
68CDK190.66742375
69MARK20.65724286
70MAP3K130.64945561
71PRKCZ0.63198445
72LMTK20.63170769
73WNK40.62700006
74LIMK10.62084038
75CAMK10.61381890
76SGK10.55614097
77STK110.55306678
78FER0.54160895
79GRK70.52935414
80MAP3K110.52750238
81CSNK1G10.52130448
82CSNK1G30.52038709
83FGR0.51652386
84PRKCE0.50825977
85PRKCH0.50475847
86FYN0.50399212
87CAMK2D0.50356484
88SGK30.47480742
89RPS6KA20.46272572
90PRKG10.44825623
91MAP2K10.44786520
92PRKACA0.43935088
93BMPR1B0.43217691
94GRK10.42811635
95ADRBK10.41004974
96MAP2K60.40145828
97INSRR0.40034842
98TRIM280.39949187
99PDK10.38672525
100RPS6KA30.38375026
101PRKCA0.37884138
102CSNK1E0.37318061
103CAMKK20.36833238
104CAMK2G0.35878093
105MAPK100.35691086
106CSNK1A10.35510100
107CSNK1D0.35442028
108STK390.34988813
109TAOK30.34948149
110ERBB20.33339386
111PDPK10.32194128
112AKT30.32089974
113FGFR20.31586167
114ALK0.30892621
115PINK10.30874127
116CSNK1A1L0.30477786
117TAOK10.29710957
118CCNB10.29578012
119MAP3K60.29565084
120BRAF0.28944043
121PRKCB0.28903242
122MAPK80.28612099
123CAMK1G0.27706722
124MAPKAPK50.27418509
125OXSR10.27338873
126MAP3K10.27039259

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80051077
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12743219
3Olfactory transduction_Homo sapiens_hsa047402.87744954
4Circadian entrainment_Homo sapiens_hsa047132.71609399
5Long-term potentiation_Homo sapiens_hsa047202.68149575
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65091824
7Amphetamine addiction_Homo sapiens_hsa050312.61510379
8GABAergic synapse_Homo sapiens_hsa047272.55471860
9Glutamatergic synapse_Homo sapiens_hsa047242.52902585
10Morphine addiction_Homo sapiens_hsa050322.41682821
11Dopaminergic synapse_Homo sapiens_hsa047282.38499958
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10828102
13Salivary secretion_Homo sapiens_hsa049702.07342954
14Cholinergic synapse_Homo sapiens_hsa047251.98952701
15Insulin secretion_Homo sapiens_hsa049111.87449457
16Serotonergic synapse_Homo sapiens_hsa047261.87397939
17Cocaine addiction_Homo sapiens_hsa050301.87135997
18Taste transduction_Homo sapiens_hsa047421.78858172
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75629653
20Gastric acid secretion_Homo sapiens_hsa049711.73550181
21Renin secretion_Homo sapiens_hsa049241.68011074
22Long-term depression_Homo sapiens_hsa047301.63623654
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61548300
24Calcium signaling pathway_Homo sapiens_hsa040201.60416890
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59730743
26Axon guidance_Homo sapiens_hsa043601.56054968
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52757985
28Gap junction_Homo sapiens_hsa045401.49001113
29GnRH signaling pathway_Homo sapiens_hsa049121.47172430
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42637583
31Collecting duct acid secretion_Homo sapiens_hsa049661.40264808
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34162719
33Glioma_Homo sapiens_hsa052141.23211228
34cAMP signaling pathway_Homo sapiens_hsa040241.20467382
35ErbB signaling pathway_Homo sapiens_hsa040121.16406401
36Estrogen signaling pathway_Homo sapiens_hsa049151.14441408
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12789564
38Melanogenesis_Homo sapiens_hsa049161.10719252
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08263004
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08203239
41Type II diabetes mellitus_Homo sapiens_hsa049301.05350271
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96166657
43Vibrio cholerae infection_Homo sapiens_hsa051100.93808655
44Oocyte meiosis_Homo sapiens_hsa041140.92201255
45Phototransduction_Homo sapiens_hsa047440.91740488
46Cardiac muscle contraction_Homo sapiens_hsa042600.90763445
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90591937
48Dorso-ventral axis formation_Homo sapiens_hsa043200.82464101
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.82337899
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.82054305
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81333346
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.80006661
53Butanoate metabolism_Homo sapiens_hsa006500.79141840
54VEGF signaling pathway_Homo sapiens_hsa043700.78389060
55Choline metabolism in cancer_Homo sapiens_hsa052310.76650385
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76082623
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72516977
58Pancreatic secretion_Homo sapiens_hsa049720.71422805
59MAPK signaling pathway_Homo sapiens_hsa040100.71337967
60Alcoholism_Homo sapiens_hsa050340.71217516
61Oxidative phosphorylation_Homo sapiens_hsa001900.69281150
62Vitamin B6 metabolism_Homo sapiens_hsa007500.67602503
63Thyroid hormone synthesis_Homo sapiens_hsa049180.66367386
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66170517
65Ras signaling pathway_Homo sapiens_hsa040140.65188576
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63719731
67Endometrial cancer_Homo sapiens_hsa052130.63135198
68Dilated cardiomyopathy_Homo sapiens_hsa054140.62630127
69Rap1 signaling pathway_Homo sapiens_hsa040150.61146287
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60405009
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59745264
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.57075397
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54710310
74Ether lipid metabolism_Homo sapiens_hsa005650.54601224
75Parkinsons disease_Homo sapiens_hsa050120.54055522
76Glucagon signaling pathway_Homo sapiens_hsa049220.54014332
77Wnt signaling pathway_Homo sapiens_hsa043100.52795751
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51970646
79Non-small cell lung cancer_Homo sapiens_hsa052230.51154673
80Regulation of autophagy_Homo sapiens_hsa041400.50877316
81Alzheimers disease_Homo sapiens_hsa050100.50520990
82African trypanosomiasis_Homo sapiens_hsa051430.49960440
83mTOR signaling pathway_Homo sapiens_hsa041500.49437094
84Prion diseases_Homo sapiens_hsa050200.49305746
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49138043
86Endocytosis_Homo sapiens_hsa041440.48102548
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47300289
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46799224
89Renal cell carcinoma_Homo sapiens_hsa052110.46479934
90Colorectal cancer_Homo sapiens_hsa052100.46308832
91Insulin signaling pathway_Homo sapiens_hsa049100.45253766
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44168583
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41128373
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41004883
95Nitrogen metabolism_Homo sapiens_hsa009100.40840269
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40271457
97Inositol phosphate metabolism_Homo sapiens_hsa005620.39119205
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38651462
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36902431
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36869619
101Type I diabetes mellitus_Homo sapiens_hsa049400.36014296
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35951739
103Linoleic acid metabolism_Homo sapiens_hsa005910.35801094
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35528781
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34678447
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.33032223
107Chemokine signaling pathway_Homo sapiens_hsa040620.32291565
108Prolactin signaling pathway_Homo sapiens_hsa049170.30684345
109Bile secretion_Homo sapiens_hsa049760.29061723
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28927764
111Hippo signaling pathway_Homo sapiens_hsa043900.26627785
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26470198
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26384135
114Circadian rhythm_Homo sapiens_hsa047100.26366439
115Ovarian steroidogenesis_Homo sapiens_hsa049130.25949727
116Mineral absorption_Homo sapiens_hsa049780.25030628
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24743697
118Fatty acid biosynthesis_Homo sapiens_hsa000610.23738680
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21492731
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21342765

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