SCN4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)6.27466473
2prepulse inhibition (GO:0060134)5.89370341
3synaptic transmission, dopaminergic (GO:0001963)5.86155410
4sodium ion export (GO:0071436)5.50556198
5adenosine receptor signaling pathway (GO:0001973)5.41276484
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37296179
7striatum development (GO:0021756)5.28671289
8locomotory exploration behavior (GO:0035641)5.27677731
9synaptic vesicle maturation (GO:0016188)5.24701097
10positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.04743948
11adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.89774667
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.87680648
13regulation of long-term neuronal synaptic plasticity (GO:0048169)4.76575144
14negative regulation of cytosolic calcium ion concentration (GO:0051481)4.69689776
15cerebellar granule cell differentiation (GO:0021707)4.69285340
16neuronal action potential propagation (GO:0019227)4.64793030
17auditory behavior (GO:0031223)4.63074461
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.57117719
19vocalization behavior (GO:0071625)4.56765024
20response to amphetamine (GO:0001975)4.55365143
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.51220145
22regulation of neuronal synaptic plasticity (GO:0048168)4.50812953
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48338459
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.47306083
25positive regulation of synapse maturation (GO:0090129)4.45986128
26dopamine receptor signaling pathway (GO:0007212)4.35342486
27positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.35019104
28neuromuscular process controlling balance (GO:0050885)4.33859580
29regulation of glutamate receptor signaling pathway (GO:1900449)4.32006500
30L-amino acid import (GO:0043092)4.29457174
31cAMP catabolic process (GO:0006198)4.23223324
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.21513988
33regulation of dendritic spine morphogenesis (GO:0061001)4.18032674
34positive regulation of neurotransmitter transport (GO:0051590)4.13956910
35positive regulation of synaptic transmission, GABAergic (GO:0032230)4.13092757
36behavioral response to cocaine (GO:0048148)4.12654999
37response to auditory stimulus (GO:0010996)4.07414029
38neurotransmitter-gated ion channel clustering (GO:0072578)4.05083455
39synaptic vesicle exocytosis (GO:0016079)4.03025009
40substrate-independent telencephalic tangential migration (GO:0021826)4.00070077
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.00070077
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.96539044
43regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.95035889
44regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.95035889
45regulation of synaptic vesicle exocytosis (GO:2000300)3.91249380
46cell communication by electrical coupling (GO:0010644)3.88885723
47neurotransmitter secretion (GO:0007269)3.85028424
48potassium ion homeostasis (GO:0055075)3.82172859
49amino acid import (GO:0043090)3.81909873
50potassium ion import (GO:0010107)3.81308612
51neuron-neuron synaptic transmission (GO:0007270)3.80034862
52exploration behavior (GO:0035640)3.79395362
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.79134078
54neuronal ion channel clustering (GO:0045161)3.77843023
55activation of protein kinase A activity (GO:0034199)3.74835449
56regulation of female receptivity (GO:0045924)3.72280759
57dendritic spine morphogenesis (GO:0060997)3.71660448
58regulation of synapse maturation (GO:0090128)3.71355805
59cyclic nucleotide catabolic process (GO:0009214)3.71036910
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.69068376
61ionotropic glutamate receptor signaling pathway (GO:0035235)3.68475037
62neurotransmitter transport (GO:0006836)3.67827114
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67759755
64regulation of glutamate secretion (GO:0014048)3.67269892
65negative regulation of dendrite development (GO:2000171)3.66807088
66transmission of nerve impulse (GO:0019226)3.65741165
67regulation of neurotransmitter uptake (GO:0051580)3.65434021
68peristalsis (GO:0030432)3.62731789
69long-term memory (GO:0007616)3.61728886
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.60494996
71postsynaptic membrane organization (GO:0001941)3.59622864
72neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.59609344
73regulation of protein kinase A signaling (GO:0010738)3.59526912
74protein localization to synapse (GO:0035418)3.55706583
75glycine transport (GO:0015816)3.55631423
76negative regulation of dendrite morphogenesis (GO:0050774)3.55258031
77regulation of synaptic vesicle transport (GO:1902803)3.53628395
78positive regulation of membrane potential (GO:0045838)3.52731176
79regulation of voltage-gated calcium channel activity (GO:1901385)3.52299341
80cAMP metabolic process (GO:0046058)3.51159485
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47258277
82cellular sodium ion homeostasis (GO:0006883)3.46858228
83regulation of vesicle fusion (GO:0031338)3.45329345
84positive regulation of neurotransmitter secretion (GO:0001956)3.44673042
85regulation of synaptic plasticity (GO:0048167)3.42482833
86synaptic transmission, glutamatergic (GO:0035249)3.41219439
87positive regulation of dendritic spine development (GO:0060999)3.41217776
88layer formation in cerebral cortex (GO:0021819)3.40800801
89gamma-aminobutyric acid transport (GO:0015812)3.40274938
90visual learning (GO:0008542)3.37866945
91regulation of neurotransmitter levels (GO:0001505)3.37283556
92regulation of postsynaptic membrane potential (GO:0060078)3.36399255
93neuromuscular process controlling posture (GO:0050884)3.36109740
94mechanosensory behavior (GO:0007638)3.35400232
95regulation of neurotransmitter secretion (GO:0046928)3.35167382
96* membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34191234
97cytoskeletal anchoring at plasma membrane (GO:0007016)3.34059026
98axon ensheathment in central nervous system (GO:0032291)3.33965226
99central nervous system myelination (GO:0022010)3.33965226
100membrane hyperpolarization (GO:0060081)3.31456751
101regulation of ARF protein signal transduction (GO:0032012)3.28180938
102glutamate secretion (GO:0014047)3.26942024
103neuronal action potential (GO:0019228)3.22914218
104female mating behavior (GO:0060180)3.22755179
105neuromuscular process (GO:0050905)3.20818496
106behavioral defense response (GO:0002209)3.18625632
107behavioral fear response (GO:0001662)3.18625632
108cellular potassium ion homeostasis (GO:0030007)3.16958831
109visual behavior (GO:0007632)3.15764951
110regulation of cell communication by electrical coupling (GO:0010649)3.15614036
111glutamate receptor signaling pathway (GO:0007215)3.15342214
112positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.15314680
113negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15217092
114cAMP biosynthetic process (GO:0006171)3.15076650
115regulation of dendritic spine development (GO:0060998)3.14441841
116regulation of synaptic transmission, dopaminergic (GO:0032225)3.13995530
117response to amine (GO:0014075)3.13333131
118regulation of norepinephrine secretion (GO:0014061)3.13172855
119cerebellar Purkinje cell differentiation (GO:0021702)3.11893395
120synaptic vesicle endocytosis (GO:0048488)3.09660775
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07305371
122mating behavior (GO:0007617)3.06858710
123response to histamine (GO:0034776)3.06503653
124regulation of Rap GTPase activity (GO:0032317)3.05938525
125regulation of neurotransmitter transport (GO:0051588)3.05683159
126neurotransmitter uptake (GO:0001504)3.04704539
127regulation of synaptic transmission, GABAergic (GO:0032228)3.04279974
128* membrane depolarization during action potential (GO:0086010)3.02009143
129detection of calcium ion (GO:0005513)3.01761690
130sarcoplasmic reticulum calcium ion transport (GO:0070296)3.01613505
131drinking behavior (GO:0042756)3.01278188
132gamma-aminobutyric acid signaling pathway (GO:0007214)3.01250822
133positive regulation of dendritic spine morphogenesis (GO:0061003)2.97025305
134positive regulation of vesicle fusion (GO:0031340)2.95428267
135neuromuscular synaptic transmission (GO:0007274)2.93399121
136positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90691271
137neuron cell-cell adhesion (GO:0007158)2.87919047
138proline transport (GO:0015824)2.78413026
139* cell communication involved in cardiac conduction (GO:0086065)2.77476430
140* membrane depolarization (GO:0051899)2.77322364
141acidic amino acid transport (GO:0015800)2.77149877
142dendritic spine organization (GO:0097061)2.76293759
143positive regulation of dendrite development (GO:1900006)2.76096361
144regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.76095589
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74666133
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73573275
147regulation of synaptic transmission (GO:0050804)2.68885231
148* regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.66329348
149regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65252507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76677175
2* RARB_27405468_Chip-Seq_BRAIN_Mouse4.01143374
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06089372
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02062951
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.94710792
6DROSHA_22980978_ChIP-Seq_HELA_Human2.89695821
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84064938
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71116939
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71116939
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65582650
11GBX2_23144817_ChIP-Seq_PC3_Human2.59308438
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58806911
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56752364
14REST_21632747_ChIP-Seq_MESCs_Mouse2.55872831
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54783522
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54451264
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46708438
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31167451
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.25118457
20* EZH2_27304074_Chip-Seq_ESCs_Mouse2.21900162
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.21270651
22AR_21572438_ChIP-Seq_LNCaP_Human2.15077388
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10453135
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07935498
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06772867
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.97612541
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.79898100
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67958902
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66335891
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.65443208
31* KDM2B_26808549_Chip-Seq_K562_Human1.56566525
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53162484
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49793853
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43669257
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43301068
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42458767
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41009338
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40250119
39* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37237603
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36681067
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36068432
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33661902
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33104574
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.26654911
45CTCF_27219007_Chip-Seq_Bcells_Human1.25796501
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25264819
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25055534
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.24808580
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23060169
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22338495
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22023819
52* TP53_20018659_ChIP-ChIP_R1E_Mouse1.21532080
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.20582391
54AR_19668381_ChIP-Seq_PC3_Human1.20498679
55* SMAD4_21799915_ChIP-Seq_A2780_Human1.20225766
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19550907
57TAF15_26573619_Chip-Seq_HEK293_Human1.18669056
58LXR_22292898_ChIP-Seq_THP-1_Human1.17306339
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15325442
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12838312
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11363622
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.11170535
63* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10273018
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10207430
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10048836
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.09519452
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.08333896
68* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07920959
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07426432
70STAT3_23295773_ChIP-Seq_U87_Human1.06899227
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.06791631
72KLF4_19829295_ChIP-Seq_ESCs_Human1.06745988
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06130015
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05695769
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04435482
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03508253
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01602587
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00392385
79TET1_21490601_ChIP-Seq_MESCs_Mouse0.99625337
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97347876
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97267235
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96735106
83RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95620600
84AHR_22903824_ChIP-Seq_MCF-7_Human0.95025723
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94937095
86RXR_22108803_ChIP-Seq_LS180_Human0.93672319
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.93532087
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93329168
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93021607
90TBX20_22328084_ChIP-Seq_HEART_Mouse0.91861250
91TBX20_22080862_ChIP-Seq_HEART_Mouse0.91861250
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91250351
93YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90741872
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90283064
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89823816
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88136954
97TCF4_23295773_ChIP-Seq_U87_Human0.86416879
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86396192
99KDM2B_26808549_Chip-Seq_DND41_Human0.85345899
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85286281
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85041152
102ESR2_21235772_ChIP-Seq_MCF-7_Human0.85012774
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84973673
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.84635963
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.84530530
106AR_25329375_ChIP-Seq_VCAP_Human0.84049477
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.81758025
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81173665
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.81167767
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80743471
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.80263984
112* TP53_23651856_ChIP-Seq_MEFs_Mouse0.79724652
113DPY_21335234_ChIP-Seq_ESCs_Mouse0.79611982
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79031018
115SMC4_20622854_ChIP-Seq_HELA_Human0.78645802
116CREB1_26743006_Chip-Seq_LNCaP_Human0.78017407
117RNF2_27304074_Chip-Seq_NSC_Mouse0.78010144
118* OCT4_19829295_ChIP-Seq_ESCs_Human0.77751915
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77743280
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.77302659
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77114059
122CLOCK_20551151_ChIP-Seq_293T_Human0.76399110
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75399709
124STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.75271398
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.74028723
126* MYC_27129775_Chip-Seq_CORNEA_Mouse0.72302246
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70343425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.91748121
2MP0004859_abnormal_synaptic_plasticity5.96837891
3MP0003635_abnormal_synaptic_transmissio3.84815380
4MP0003880_abnormal_central_pattern3.72294550
5MP0004270_analgesia3.55539811
6MP0009745_abnormal_behavioral_response3.47838787
7MP0002063_abnormal_learning/memory/cond3.19489791
8MP0009046_muscle_twitch2.90157319
9MP0002064_seizures2.81661184
10MP0001486_abnormal_startle_reflex2.63450467
11MP0001529_abnormal_vocalization2.60166746
12MP0002909_abnormal_adrenal_gland2.56884370
13MP0002572_abnormal_emotion/affect_behav2.52499020
14MP0002272_abnormal_nervous_system2.49306857
15MP0001968_abnormal_touch/_nociception2.43287644
16MP0005423_abnormal_somatic_nervous2.20553036
17MP0002734_abnormal_mechanical_nocicepti2.16547356
18MP0005646_abnormal_pituitary_gland1.96436893
19MP0008569_lethality_at_weaning1.92365615
20MP0005386_behavior/neurological_phenoty1.88745152
21MP0004924_abnormal_behavior1.88745152
22MP0001501_abnormal_sleep_pattern1.87840213
23MP0001970_abnormal_pain_threshold1.84363071
24MP0005409_darkened_coat_color1.84134554
25MP0002733_abnormal_thermal_nociception1.82342938
26MP0002735_abnormal_chemical_nociception1.82182657
27MP0004811_abnormal_neuron_physiology1.69616625
28MP0002736_abnormal_nociception_after1.68814319
29MP0000751_myopathy1.62509853
30MP0001984_abnormal_olfaction1.57972319
31MP0002067_abnormal_sensory_capabilities1.54220013
32MP0001346_abnormal_lacrimal_gland1.51184864
33MP0002557_abnormal_social/conspecific_i1.48567532
34MP0001440_abnormal_grooming_behavior1.41852348
35MP0003075_altered_response_to1.39649218
36MP0001188_hyperpigmentation1.39512202
37MP0003329_amyloid_beta_deposits1.38911726
38MP0004858_abnormal_nervous_system1.37919706
39MP0009780_abnormal_chondrocyte_physiolo1.36695638
40MP0003633_abnormal_nervous_system1.35770734
41MP0008874_decreased_physiological_sensi1.35309313
42MP0004145_abnormal_muscle_electrophysio1.35213181
43MP0003879_abnormal_hair_cell1.30027337
44MP0002066_abnormal_motor_capabilities/c1.28424752
45MP0000955_abnormal_spinal_cord1.28319710
46MP0005167_abnormal_blood-brain_barrier1.28135146
47MP0002184_abnormal_innervation1.27186467
48MP0000013_abnormal_adipose_tissue1.23580610
49MP0003646_muscle_fatigue1.22980672
50MP0004885_abnormal_endolymph1.21784823
51MP0008872_abnormal_physiological_respon1.18968604
52MP0004085_abnormal_heartbeat1.16109635
53MP0001177_atelectasis1.13546427
54MP0002882_abnormal_neuron_morphology1.08206845
55MP0005670_abnormal_white_adipose1.05821071
56MP0001905_abnormal_dopamine_level1.05405444
57MP0008961_abnormal_basal_metabolism1.04613565
58MP0003631_nervous_system_phenotype1.01834230
59MP0000579_abnormal_nail_morphology1.00259500
60MP0005503_abnormal_tendon_morphology0.99817622
61MP0003690_abnormal_glial_cell0.99641230
62MP0000749_muscle_degeneration0.99543021
63MP0003283_abnormal_digestive_organ0.99528687
64MP0004036_abnormal_muscle_relaxation0.99161558
65MP0004142_abnormal_muscle_tone0.98547972
66MP0000920_abnormal_myelination0.97002326
67MP0005535_abnormal_body_temperature0.95105544
68MP0001963_abnormal_hearing_physiology0.93912872
69MP0002638_abnormal_pupillary_reflex0.93022505
70MP0003137_abnormal_impulse_conducting0.92561241
71MP0004742_abnormal_vestibular_system0.92182598
72MP0000733_abnormal_muscle_development0.91899265
73MP0000747_muscle_weakness0.91748360
74MP0006276_abnormal_autonomic_nervous0.88295478
75MP0003123_paternal_imprinting0.86111190
76MP0002971_abnormal_brown_adipose0.85828476
77MP0002069_abnormal_eating/drinking_beha0.85786640
78MP0005666_abnormal_adipose_tissue0.85077607
79MP0002249_abnormal_larynx_morphology0.84483814
80MP0001348_abnormal_lacrimal_gland0.84188797
81MP0010234_abnormal_vibrissa_follicle0.84135500
82MP0000778_abnormal_nervous_system0.83823673
83MP0005620_abnormal_muscle_contractility0.83462506
84MP0005623_abnormal_meninges_morphology0.80977165
85MP0002108_abnormal_muscle_morphology0.80937785
86MP0003787_abnormal_imprinting0.80763633
87MP0002229_neurodegeneration0.79112451
88MP0002090_abnormal_vision0.79084982
89MP0004147_increased_porphyrin_level0.78613824
90MP0001502_abnormal_circadian_rhythm0.78028986
91MP0002152_abnormal_brain_morphology0.76230943
92MP0004130_abnormal_muscle_cell0.75647632
93MP0005388_respiratory_system_phenotype0.74987869
94MP0002133_abnormal_respiratory_system0.74987869
95MP0002837_dystrophic_cardiac_calcinosis0.74618086
96MP0000569_abnormal_digit_pigmentation0.72129662
97MP0004043_abnormal_pH_regulation0.71200730
98MP0005375_adipose_tissue_phenotype0.69939161
99MP0003634_abnormal_glial_cell0.69663379
100MP0003705_abnormal_hypodermis_morpholog0.69400718
101MP0004215_abnormal_myocardial_fiber0.69195607
102MP0004084_abnormal_cardiac_muscle0.69113192
103MP0006138_congestive_heart_failure0.68767184
104MP0004087_abnormal_muscle_fiber0.67693053
105MP0004233_abnormal_muscle_weight0.67164766
106MP0003122_maternal_imprinting0.65128521
107MP0005166_decreased_susceptibility_to0.65081919
108MP0010030_abnormal_orbit_morphology0.64333095
109MP0004510_myositis0.63521664
110MP0000759_abnormal_skeletal_muscle0.63415470
111MP0000604_amyloidosis0.61848128
112MP0005645_abnormal_hypothalamus_physiol0.61639835
113MP0002269_muscular_atrophy0.61020999
114MP0001485_abnormal_pinna_reflex0.60367066
115MP0005394_taste/olfaction_phenotype0.57690925
116MP0005499_abnormal_olfactory_system0.57690925
117MP0002106_abnormal_muscle_physiology0.53212706
118MP0001299_abnormal_eye_distance/0.52362931
119MP0000003_abnormal_adipose_tissue0.50722857
120MP0003632_abnormal_nervous_system0.49678638
121MP0005369_muscle_phenotype0.48178345
122MP0001943_abnormal_respiration0.47403007
123MP0003956_abnormal_body_size0.45097682
124MP0001664_abnormal_digestion0.44762722
125MP0004484_altered_response_of0.43102690
126MP0000631_abnormal_neuroendocrine_gland0.42934448

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.55254373
2Focal motor seizures (HP:0011153)7.21275104
3Focal seizures (HP:0007359)5.32235698
4Action tremor (HP:0002345)4.69381406
5Resting tremor (HP:0002322)4.59719775
6Torticollis (HP:0000473)4.23127574
7Annular pancreas (HP:0001734)4.22776713
8Ankle clonus (HP:0011448)4.12699071
9Obstructive sleep apnea (HP:0002870)4.03562615
10Poor eye contact (HP:0000817)3.89123565
11Visual hallucinations (HP:0002367)3.79747177
12Anxiety (HP:0000739)3.76898739
13Neurofibrillary tangles (HP:0002185)3.70207175
14Impaired vibration sensation in the lower limbs (HP:0002166)3.66553488
15Abnormal social behavior (HP:0012433)3.65890931
16Impaired social interactions (HP:0000735)3.65890931
17Diplopia (HP:0000651)3.64846951
18Abnormality of binocular vision (HP:0011514)3.64846951
19Focal dystonia (HP:0004373)3.58125308
20Craniofacial dystonia (HP:0012179)3.58045732
21Muscle fiber inclusion bodies (HP:0100299)3.57453046
22Depression (HP:0000716)3.56002844
23Febrile seizures (HP:0002373)3.44407127
24Nemaline bodies (HP:0003798)3.41868636
25Urinary bladder sphincter dysfunction (HP:0002839)3.39402427
26Urinary urgency (HP:0000012)3.38784893
27Generalized tonic-clonic seizures (HP:0002069)3.37869354
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.36082486
29Lower limb amyotrophy (HP:0007210)3.29997435
30Dysdiadochokinesis (HP:0002075)3.29796172
31Exercise-induced myalgia (HP:0003738)3.29167869
32Broad-based gait (HP:0002136)3.24238193
33Ankyloglossia (HP:0010296)3.23515699
34Dysmetric saccades (HP:0000641)3.20218924
35Muscle fiber splitting (HP:0003555)3.19803117
36Type 1 muscle fiber predominance (HP:0003803)3.19708985
37Absence seizures (HP:0002121)3.14450659
38Scanning speech (HP:0002168)3.09100003
39Atonic seizures (HP:0010819)3.05988197
40Gaze-evoked nystagmus (HP:0000640)3.04872221
41Cerebral inclusion bodies (HP:0100314)3.00519943
42Distal lower limb amyotrophy (HP:0008944)2.99592894
43Supranuclear gaze palsy (HP:0000605)2.97257108
44Epileptic encephalopathy (HP:0200134)2.96650608
45Postural instability (HP:0002172)2.93573767
46Ventricular fibrillation (HP:0001663)2.91370917
47Pointed chin (HP:0000307)2.89800635
48Tetraplegia (HP:0002445)2.88858011
49Dialeptic seizures (HP:0011146)2.88171360
50Dysmetria (HP:0001310)2.83812713
51Spastic gait (HP:0002064)2.80378936
52Stereotypic behavior (HP:0000733)2.79688132
53Truncal ataxia (HP:0002078)2.79136339
54Progressive cerebellar ataxia (HP:0002073)2.68300700
55Bundle branch block (HP:0011710)2.68057764
56Calcaneovalgus deformity (HP:0001848)2.66557817
57Papilledema (HP:0001085)2.65748248
58Polygenic inheritance (HP:0010982)2.64158089
59Intention tremor (HP:0002080)2.56037195
60Impaired vibratory sensation (HP:0002495)2.52186032
61Abnormal eating behavior (HP:0100738)2.47694701
62Axonal loss (HP:0003447)2.45478592
63Clonus (HP:0002169)2.44961450
64Distal upper limb amyotrophy (HP:0007149)2.44655808
65Upper limb amyotrophy (HP:0009129)2.44655808
66Impaired smooth pursuit (HP:0007772)2.42697143
67EMG: myopathic abnormalities (HP:0003458)2.41588055
68Abnormality of skeletal muscle fiber size (HP:0012084)2.39490887
69Myopathic facies (HP:0002058)2.38594204
70Cerebral hypomyelination (HP:0006808)2.37362509
71Bradykinesia (HP:0002067)2.37154234
72Insidious onset (HP:0003587)2.36129718
73Termporal pattern (HP:0011008)2.36129718
74Abnormality of oral frenula (HP:0000190)2.33299985
75Megalencephaly (HP:0001355)2.31658138
76Exercise-induced muscle cramps (HP:0003710)2.31163498
77Sleep apnea (HP:0010535)2.30971261
78Lower limb muscle weakness (HP:0007340)2.29450756
79Onion bulb formation (HP:0003383)2.28913189
80Deformed tarsal bones (HP:0008119)2.28229195
81EMG: neuropathic changes (HP:0003445)2.28116677
82Hemiparesis (HP:0001269)2.25894070
83Difficulty running (HP:0009046)2.22263043
84Sudden death (HP:0001699)2.20785663
85Abnormality of the lower motor neuron (HP:0002366)2.20410960
86Centrally nucleated skeletal muscle fibers (HP:0003687)2.18787636
87Incomplete penetrance (HP:0003829)2.18482926
88Frequent falls (HP:0002359)2.16876874
89Akinesia (HP:0002304)2.16236424
90Limb dystonia (HP:0002451)2.13156370
91Muscle stiffness (HP:0003552)2.12980396
92Fetal akinesia sequence (HP:0001989)2.12925256
93Hammertoe (HP:0001765)2.12763319
94Limb hypertonia (HP:0002509)2.10447776
95Foot dorsiflexor weakness (HP:0009027)2.05828398
96Pheochromocytoma (HP:0002666)2.05727991
97Hemiplegia (HP:0002301)2.04411866
98Lower limb asymmetry (HP:0100559)2.02494785
99Amblyopia (HP:0000646)2.02482999
100Myotonia (HP:0002486)2.02391904
101Bronchomalacia (HP:0002780)2.01482666
102Abnormality of saccadic eye movements (HP:0000570)2.01350733
103Status epilepticus (HP:0002133)2.00830429
104Progressive inability to walk (HP:0002505)1.99630623
105Bowel incontinence (HP:0002607)1.99582630
106Muscle hypertrophy of the lower extremities (HP:0008968)1.98942546
107Abnormality of ocular smooth pursuit (HP:0000617)1.98658021
108Neoplasm of the peripheral nervous system (HP:0100007)1.97383660
109* Abnormal EKG (HP:0003115)1.96656999
110Rigidity (HP:0002063)1.95221568
111Abnormality of pain sensation (HP:0010832)1.95072465
112Impaired pain sensation (HP:0007328)1.95072465
113* Heart block (HP:0012722)1.95043352
114Subaortic stenosis (HP:0001682)1.94782922
115Abnormality of the left ventricular outflow tract (HP:0011103)1.94782922
116Mutism (HP:0002300)1.93193749
117Abnormality of the foot musculature (HP:0001436)1.92744379
118Calf muscle hypertrophy (HP:0008981)1.92735527
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92198905
120Round ear (HP:0100830)1.91619380
121Turricephaly (HP:0000262)1.89374421
122Abnormality of the periventricular white matter (HP:0002518)1.88612647
123Increased variability in muscle fiber diameter (HP:0003557)1.87688580
124Spinal canal stenosis (HP:0003416)1.85043780
125Dysphonia (HP:0001618)1.83708152
126Hyporeflexia of lower limbs (HP:0002600)1.82454382
127Insomnia (HP:0100785)1.82453634
128Neuronal loss in central nervous system (HP:0002529)1.82324263
129Slow progression (HP:0003677)1.81830346
130* Abnormal atrioventricular conduction (HP:0005150)1.81634273
131Cerebral aneurysm (HP:0004944)1.81156341
132Truncus arteriosus (HP:0001660)1.81049111
133Abnormal large intestine physiology (HP:0012700)1.81023763
134Apathy (HP:0000741)1.80394229
135Epileptiform EEG discharges (HP:0011182)1.79585163
136Rapidly progressive (HP:0003678)1.79156521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.37989518
2NTRK34.06341363
3MAP3K93.24825994
4KSR22.86171200
5PRKD32.69707555
6DAPK22.61819243
7RIPK42.56323003
8CAMKK12.47714171
9MINK12.28034746
10NTRK12.27118981
11MAP3K41.83725495
12FES1.83209572
13TAOK11.81387001
14PAK61.68627332
15CAMKK21.62818626
16MAP3K21.61146467
17NTRK21.56878697
18PINK11.53940494
19MAP3K131.52659120
20CDK51.52229834
21ARAF1.49763811
22KSR11.45226879
23PHKG21.40703237
24PHKG11.40703237
25LMTK21.38461111
26MAPK121.34457732
27TYRO31.30834882
28NEK11.30371017
29MAP2K41.30020707
30MARK11.29296244
31DAPK11.26660880
32STK381.24034692
33SIK21.18959120
34TNIK1.18032620
35MAP2K71.17673946
36SGK2231.15980808
37SGK4941.15980808
38CASK1.11569247
39PRKCH1.10000994
40SGK21.06492554
41SGK31.05466072
42TRIB31.03333059
43WNK11.03301787
44RIPK11.02293860
45RAF11.01925945
46DYRK1A1.00128346
47MOS0.98209752
48PRPF4B0.97333089
49PLK20.95908573
50RET0.95322594
51PDPK10.88639650
52TNK20.86530599
53EEF2K0.85755156
54BMPR20.84815916
55MAP3K10.84520915
56UHMK10.83550220
57STK110.82464339
58PRKCG0.82311070
59MARK20.81047579
60SGK10.80894096
61PDK10.80630934
62MAPK130.75594604
63ROCK20.75242504
64PKN10.73965352
65ALK0.73936178
66SCYL20.71352663
67MAP2K10.70481306
68CDK150.70309706
69DMPK0.70275373
70CAMK10.69818643
71CDK180.69538374
72CDK140.68242149
73TRPM70.64600412
74CAMK2A0.64252781
75OBSCN0.61243784
76CDK11A0.59903226
77CAMK2B0.58862187
78PTK2B0.58583954
79RPS6KA30.58261245
80DDR20.57740070
81NEK60.56475557
82BRSK10.55332929
83MAP3K120.54697193
84MAP3K70.53222688
85MAPK70.51838238
86ROCK10.51677798
87TESK10.51239448
88MAPK100.49683036
89GRK50.49673667
90FYN0.48740126
91CAMK2G0.48711515
92PRKD20.47736068
93PRKCZ0.46781888
94CAMK40.46437401
95DAPK30.43961212
96PRKG10.42784786
97LIMK10.42518734
98CDC42BPA0.41066630
99MUSK0.38880735
100BRAF0.38870517
101CAMK1G0.38074200
102PDGFRA0.37664239
103MAPK40.37466190
104PRKD10.37255528
105CAMK2D0.35898590
106RPS6KA20.35709828
107PRKACG0.33581121
108PRKCB0.33076618
109BMX0.32574241
110CAMK1D0.32125188
111MAP2K60.32058691
112PRKAA10.31961263
113CDK190.31815216
114PRKACA0.31166581
115FGFR20.30611775
116MAP3K110.30063664
117MAPKAPK50.30047819
118WNK40.29542816
119CSNK1A10.28897025
120TTN0.28725077
121PTK20.28247297
122MAPK80.28082084
123PAK30.26664000
124LATS20.26483770

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.85309361
2Morphine addiction_Homo sapiens_hsa050322.70541691
3Circadian entrainment_Homo sapiens_hsa047132.63147089
4Amphetamine addiction_Homo sapiens_hsa050312.57169391
5Cocaine addiction_Homo sapiens_hsa050302.49245152
6GABAergic synapse_Homo sapiens_hsa047272.48641315
7Long-term potentiation_Homo sapiens_hsa047202.47869938
8Synaptic vesicle cycle_Homo sapiens_hsa047212.46525071
9Nicotine addiction_Homo sapiens_hsa050332.38733010
10Dopaminergic synapse_Homo sapiens_hsa047282.35726003
11Glutamatergic synapse_Homo sapiens_hsa047242.31653408
12Cholinergic synapse_Homo sapiens_hsa047252.22291068
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14277872
14Nitrogen metabolism_Homo sapiens_hsa009102.03307815
15Salivary secretion_Homo sapiens_hsa049701.97989433
16Renin secretion_Homo sapiens_hsa049241.97179753
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91450702
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90797809
19Gastric acid secretion_Homo sapiens_hsa049711.88170130
20Oxytocin signaling pathway_Homo sapiens_hsa049211.84508467
21* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77852042
22Insulin secretion_Homo sapiens_hsa049111.74416333
23Calcium signaling pathway_Homo sapiens_hsa040201.73169277
24Gap junction_Homo sapiens_hsa045401.55867826
25GnRH signaling pathway_Homo sapiens_hsa049121.49953369
26cAMP signaling pathway_Homo sapiens_hsa040241.38434289
27Serotonergic synapse_Homo sapiens_hsa047261.38011396
28Long-term depression_Homo sapiens_hsa047301.36924569
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35832106
30Taste transduction_Homo sapiens_hsa047421.32837846
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28904383
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25098191
33Glioma_Homo sapiens_hsa052141.18311028
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10247437
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09354473
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08930059
37Dilated cardiomyopathy_Homo sapiens_hsa054141.08002082
38Type II diabetes mellitus_Homo sapiens_hsa049301.07398894
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.07338208
40Cardiac muscle contraction_Homo sapiens_hsa042601.05048005
41Estrogen signaling pathway_Homo sapiens_hsa049150.99692279
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.97239954
43Vitamin B6 metabolism_Homo sapiens_hsa007500.95601438
44ErbB signaling pathway_Homo sapiens_hsa040120.91346931
45Melanogenesis_Homo sapiens_hsa049160.89433974
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89014130
47Non-small cell lung cancer_Homo sapiens_hsa052230.87857321
48Dorso-ventral axis formation_Homo sapiens_hsa043200.86604352
49Oocyte meiosis_Homo sapiens_hsa041140.85403171
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83046215
51Pancreatic secretion_Homo sapiens_hsa049720.81859067
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79371010
53Alcoholism_Homo sapiens_hsa050340.78844015
54Arginine and proline metabolism_Homo sapiens_hsa003300.77893775
55Rap1 signaling pathway_Homo sapiens_hsa040150.77424437
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.76802430
57Histidine metabolism_Homo sapiens_hsa003400.76702821
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76095750
59VEGF signaling pathway_Homo sapiens_hsa043700.74999057
60Thyroid hormone synthesis_Homo sapiens_hsa049180.72475768
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70531679
62MAPK signaling pathway_Homo sapiens_hsa040100.70195265
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69629605
64Axon guidance_Homo sapiens_hsa043600.68483939
65Glucagon signaling pathway_Homo sapiens_hsa049220.68392583
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67741846
67mTOR signaling pathway_Homo sapiens_hsa041500.67511263
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67164209
69AMPK signaling pathway_Homo sapiens_hsa041520.66336959
70Bile secretion_Homo sapiens_hsa049760.65898564
71Phototransduction_Homo sapiens_hsa047440.65813175
72Choline metabolism in cancer_Homo sapiens_hsa052310.64064121
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63332375
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60561130
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60478034
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60159583
77Insulin signaling pathway_Homo sapiens_hsa049100.58552457
78Chemokine signaling pathway_Homo sapiens_hsa040620.56159522
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55496857
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55208981
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.54442754
82Phenylalanine metabolism_Homo sapiens_hsa003600.53708328
83Wnt signaling pathway_Homo sapiens_hsa043100.52816054
84Platelet activation_Homo sapiens_hsa046110.51837979
85Endocytosis_Homo sapiens_hsa041440.51389483
86beta-Alanine metabolism_Homo sapiens_hsa004100.50562735
87Ras signaling pathway_Homo sapiens_hsa040140.50299142
88Endometrial cancer_Homo sapiens_hsa052130.50058249
89Type I diabetes mellitus_Homo sapiens_hsa049400.48423091
90Arginine biosynthesis_Homo sapiens_hsa002200.47689278
91Circadian rhythm_Homo sapiens_hsa047100.47257807
92Collecting duct acid secretion_Homo sapiens_hsa049660.47163098
93Thyroid cancer_Homo sapiens_hsa052160.46865377
94PPAR signaling pathway_Homo sapiens_hsa033200.45415407
95Inositol phosphate metabolism_Homo sapiens_hsa005620.42633737
96Vibrio cholerae infection_Homo sapiens_hsa051100.40865316
97Prion diseases_Homo sapiens_hsa050200.40488206
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.38541012
99Focal adhesion_Homo sapiens_hsa045100.38398576
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38271809
101Renal cell carcinoma_Homo sapiens_hsa052110.37478137
102Fatty acid biosynthesis_Homo sapiens_hsa000610.35947134
103Amoebiasis_Homo sapiens_hsa051460.35779269
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35080962
105ECM-receptor interaction_Homo sapiens_hsa045120.35043899
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.33919728
107Ovarian steroidogenesis_Homo sapiens_hsa049130.33132505
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32899870
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32230472
110Insulin resistance_Homo sapiens_hsa049310.31971268
111Protein digestion and absorption_Homo sapiens_hsa049740.31922988
112Butanoate metabolism_Homo sapiens_hsa006500.31881447
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.29908678
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29838492
115Tight junction_Homo sapiens_hsa045300.29438987
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27777301

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