SCN5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.54267185
2cardiac myofibril assembly (GO:0055003)8.97920265
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.10534819
4myofibril assembly (GO:0030239)7.82874675
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.51860121
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.34067068
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.03331437
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.70944594
9cardiac muscle cell development (GO:0055013)6.59716182
10* cardiac muscle contraction (GO:0060048)6.59582117
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.49845467
12muscle filament sliding (GO:0030049)6.45098375
13actin-myosin filament sliding (GO:0033275)6.45098375
14plasma membrane repair (GO:0001778)6.34116694
15tricarboxylic acid cycle (GO:0006099)6.34087083
16cardiac cell development (GO:0055006)6.19700960
17regulation of relaxation of muscle (GO:1901077)5.99807378
18adult heart development (GO:0007512)5.92443095
19actomyosin structure organization (GO:0031032)5.90737032
20ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.79758761
21cardiac muscle tissue morphogenesis (GO:0055008)5.79481990
22cardiac muscle hypertrophy (GO:0003300)5.60304552
23regulation of sarcomere organization (GO:0060297)5.40596825
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.37565788
25actin-mediated cell contraction (GO:0070252)5.35499536
26regulation of skeletal muscle contraction (GO:0014819)5.34226743
27heart trabecula formation (GO:0060347)5.34204429
28* ventricular cardiac muscle cell action potential (GO:0086005)5.31829647
29striated muscle hypertrophy (GO:0014897)5.29429801
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.23453282
31* regulation of actin filament-based movement (GO:1903115)5.22151984
32muscle tissue morphogenesis (GO:0060415)5.21338662
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.18799076
34carnitine shuttle (GO:0006853)5.12478448
35regulation of the force of heart contraction (GO:0002026)5.04751099
36cardiac chamber formation (GO:0003207)5.03195649
37* striated muscle contraction (GO:0006941)5.02946379
38regulation of cell communication by electrical coupling (GO:0010649)4.98540112
39* regulation of striated muscle contraction (GO:0006942)4.82485341
40sarcoplasmic reticulum calcium ion transport (GO:0070296)4.79964088
41regulation of acyl-CoA biosynthetic process (GO:0050812)4.73003759
42heart contraction (GO:0060047)4.70603018
43heart process (GO:0003015)4.70603018
44muscle hypertrophy (GO:0014896)4.67868055
45cardiac ventricle formation (GO:0003211)4.66015031
46cell communication by electrical coupling (GO:0010644)4.65201397
47* cell communication involved in cardiac conduction (GO:0086065)4.53557715
48fatty acid transmembrane transport (GO:1902001)4.42654548
49* regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.37680450
50regulation of cofactor metabolic process (GO:0051193)4.30950728
51regulation of coenzyme metabolic process (GO:0051196)4.30950728
52relaxation of cardiac muscle (GO:0055119)4.26571288
53positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.25134251
54neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.22224845
55negative regulation of potassium ion transport (GO:0043267)4.18421367
56negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.18240113
57atrial septum morphogenesis (GO:0060413)4.14739713
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14621806
59* regulation of membrane repolarization (GO:0060306)4.10359565
60* regulation of cardiac muscle contraction (GO:0055117)4.10182502
61actin filament-based movement (GO:0030048)4.06863845
62adrenergic receptor signaling pathway (GO:0071875)4.05929426
63* regulation of heart rate (GO:0002027)4.05884108
64oxygen transport (GO:0015671)4.04292608
65cellular response to epinephrine stimulus (GO:0071872)4.03576752
66regulation of cardioblast differentiation (GO:0051890)3.99897789
67* bundle of His cell to Purkinje myocyte communication (GO:0086069)3.98131315
68negative regulation of striated muscle cell apoptotic process (GO:0010664)3.95174211
69regulation of ATPase activity (GO:0043462)3.90284511
70regulation of ATP catabolic process (GO:1903289)3.90284511
71atrioventricular valve morphogenesis (GO:0003181)3.89920380
72response to epinephrine (GO:0071871)3.89611733
73cardiac muscle hypertrophy in response to stress (GO:0014898)3.88809527
74muscle hypertrophy in response to stress (GO:0003299)3.88809527
75cardiac muscle adaptation (GO:0014887)3.88809527
76NADH metabolic process (GO:0006734)3.87840230
772-oxoglutarate metabolic process (GO:0006103)3.86970965
78* regulation of heart contraction (GO:0008016)3.86188123
79negative regulation of protein localization to cell surface (GO:2000009)3.85224657
80ATP synthesis coupled proton transport (GO:0015986)3.83377932
81energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83377932
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81960515
83response to caffeine (GO:0031000)3.78594650
84carnitine transmembrane transport (GO:1902603)3.77245488
85positive regulation of cation channel activity (GO:2001259)3.72453548
86ventricular cardiac muscle cell development (GO:0055015)3.71854044
87creatine metabolic process (GO:0006600)3.71621046
88respiratory electron transport chain (GO:0022904)3.71248672
89* cardiac muscle cell action potential involved in contraction (GO:0086002)3.69901188
90positive regulation of heart rate (GO:0010460)3.69239698
91* cardiac muscle cell action potential (GO:0086001)3.68917988
92striated muscle cell development (GO:0055002)3.68463708
93positive regulation of heart contraction (GO:0045823)3.66973228
94* regulation of cardiac muscle cell contraction (GO:0086004)3.66559894
95electron transport chain (GO:0022900)3.59926858
96* regulation of muscle contraction (GO:0006937)3.58970946
97oxidative phosphorylation (GO:0006119)3.58961927
98regulation of sequestering of triglyceride (GO:0010889)3.56692128
99detection of calcium ion (GO:0005513)3.55848828
100negative regulation of cytosolic calcium ion concentration (GO:0051481)3.54943783
101regulation of calcium ion transmembrane transport (GO:1903169)3.53760715
102regulation of calcium ion transmembrane transporter activity (GO:1901019)3.53760715
103regulation of sulfur metabolic process (GO:0042762)3.50780213
104muscle cell fate commitment (GO:0042693)3.48792674
105* muscle system process (GO:0003012)3.48219113
106cell migration involved in heart development (GO:0060973)3.48113836
107amino-acid betaine transport (GO:0015838)3.42495181
108carnitine transport (GO:0015879)3.42495181
109positive regulation of ATP catabolic process (GO:1903291)3.42256224
110positive regulation of ATPase activity (GO:0032781)3.42256224
111cardiac muscle tissue development (GO:0048738)3.40511235
112potassium ion export (GO:0071435)3.39218126
113trabecula formation (GO:0060343)3.38769422
114negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.38736112
115* regulation of muscle system process (GO:0090257)3.35091917
116* muscle contraction (GO:0006936)3.32091218
117calcium-mediated signaling using intracellular calcium source (GO:0035584)3.30227083
118regulation of fatty acid oxidation (GO:0046320)3.27085803
119muscle cell development (GO:0055001)3.26392465
120aspartate family amino acid catabolic process (GO:0009068)3.25126033
121positive regulation of cardiac muscle tissue growth (GO:0055023)3.23660376
122striated muscle adaptation (GO:0014888)3.20476569
123regulation of cardioblast proliferation (GO:0003264)3.17328338
124regulation of secondary heart field cardioblast proliferation (GO:0003266)3.17328338
125gap junction assembly (GO:0016264)3.16505398
126muscle adaptation (GO:0043500)3.11440786
127positive regulation of cardiac muscle cell proliferation (GO:0060045)3.02984110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.03290714
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.95839638
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.05187164
4* TBX20_22328084_ChIP-Seq_HEART_Mouse4.01485567
5* TBX20_22080862_ChIP-Seq_HEART_Mouse4.01485567
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.64239551
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.44667340
8ZNF263_19887448_ChIP-Seq_K562_Human3.36349023
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.04575434
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.02236227
11EZH2_22144423_ChIP-Seq_EOC_Human2.91306959
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64597248
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.41988901
14GATA4_21415370_ChIP-Seq_HL-1_Mouse2.21612834
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.16726505
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10948564
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94429135
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91765962
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.90359965
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.81808369
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78287194
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.75607856
23NFIB_24661679_ChIP-Seq_LUNG_Mouse1.72669419
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66362209
25DROSHA_22980978_ChIP-Seq_HELA_Human1.59491729
26CLOCK_20551151_ChIP-Seq_293T_Human1.58117882
27NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.57359136
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56010809
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54992058
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48315199
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46834007
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42487503
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41823915
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40620155
35VDR_22108803_ChIP-Seq_LS180_Human1.39948905
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35628880
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33627878
38* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33230328
39KDM2B_26808549_Chip-Seq_DND41_Human1.33016964
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31235432
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30054813
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.29595621
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27651333
44CTCF_27219007_Chip-Seq_Bcells_Human1.22997801
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.22994475
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21094305
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.19313590
48LXR_22292898_ChIP-Seq_THP-1_Human1.18960897
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17305927
50GATA1_19941826_ChIP-Seq_K562_Human1.16304585
51* TP63_22573176_ChIP-Seq_HFKS_Human1.14348019
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13689879
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.11576837
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.11447246
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10963329
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10901695
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10778486
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09215663
59GATA1_22025678_ChIP-Seq_K562_Human1.08323906
60PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07534318
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.07038629
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06009953
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05589302
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05497853
65RACK7_27058665_Chip-Seq_MCF-7_Human1.04638825
66* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04411323
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02088710
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02024701
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01695858
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01652267
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.00747310
72* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99736452
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99681529
74FOXA2_19822575_ChIP-Seq_HepG2_Human0.99680033
75ATF3_27146783_Chip-Seq_COLON_Human0.99531003
76ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99429778
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98587596
78KDM2B_26808549_Chip-Seq_K562_Human0.98533465
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97896076
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97464124
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97280159
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97242347
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.94841918
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94818342
85SMAD4_21799915_ChIP-Seq_A2780_Human0.94589879
86WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94202970
87P68_20966046_ChIP-Seq_HELA_Human0.92817802
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92210097
89EED_16625203_ChIP-ChIP_MESCs_Mouse0.90922990
90TP53_23651856_ChIP-Seq_MEFs_Mouse0.90403925
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.89926532
92* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88938060
93GF1_26923725_Chip-Seq_HPCs_Mouse0.88494091
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.87442462
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87385796
96GATA2_19941826_ChIP-Seq_K562_Human0.86968482
97TBL1_22424771_ChIP-Seq_293T_Human0.86958474
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86749425
99* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86563709
100* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85649764
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85593287
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85515942
103AHR_22903824_ChIP-Seq_MCF-7_Human0.85259991
104STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84145673
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83854078
106BRD4_25478319_ChIP-Seq_HGPS_Human0.83632776
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83390607
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83087079
109SPI1_23127762_ChIP-Seq_K562_Human0.82991329
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82279616
111* SOX2_21211035_ChIP-Seq_LN229_Gbm0.81976493
112SPI1_20517297_ChIP-Seq_HL60_Human0.81914380
113* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81659950
114* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81473550
115* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81473550
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81413235
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.80609686
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.80313344
119* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80027687
120* EZH2_27304074_Chip-Seq_ESCs_Mouse0.79547738
121OCT4_20526341_ChIP-Seq_ESCs_Human0.79045850
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78825938
123CJUN_26792858_Chip-Seq_BT549_Human0.78667833
124STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78302347
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77921965
126* EZH2_27294783_Chip-Seq_ESCs_Mouse0.77474718
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77375096
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76853199
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76376801
130TP53_16413492_ChIP-PET_HCT116_Human0.75988833
131* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.74759622
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74428726
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73193493
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73193493
135SOX9_26525672_Chip-Seq_HEART_Mouse0.73077687
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72942596
137* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.72306894
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70973922
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70866195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.39749462
2MP0004084_abnormal_cardiac_muscle6.02354048
3MP0003646_muscle_fatigue5.56223277
4MP0000751_myopathy5.24774017
5* MP0004215_abnormal_myocardial_fiber4.79961286
6MP0004036_abnormal_muscle_relaxation4.23550052
7MP0005330_cardiomyopathy4.02692126
8MP0000749_muscle_degeneration3.64897878
9* MP0002972_abnormal_cardiac_muscle3.13935306
10MP0008775_abnormal_heart_ventricle3.04430843
11* MP0004087_abnormal_muscle_fiber3.01094714
12MP0000750_abnormal_muscle_regeneration2.85036754
13* MP0003137_abnormal_impulse_conducting2.82039275
14MP0005620_abnormal_muscle_contractility2.63735423
15* MP0010630_abnormal_cardiac_muscle2.61500028
16* MP0005385_cardiovascular_system_phenoty2.61070963
17* MP0001544_abnormal_cardiovascular_syste2.61070963
18MP0006138_congestive_heart_failure2.54737299
19MP0004484_altered_response_of2.51961177
20MP0002106_abnormal_muscle_physiology2.42832119
21MP0004130_abnormal_muscle_cell2.38525383
22MP0003828_pulmonary_edema2.31761419
23MP0002269_muscular_atrophy2.20719572
24* MP0004085_abnormal_heartbeat2.14614722
25MP0004510_myositis2.14370446
26MP0005369_muscle_phenotype1.97089924
27MP0003221_abnormal_cardiomyocyte_apopto1.94466786
28MP0000759_abnormal_skeletal_muscle1.86888702
29MP0000747_muscle_weakness1.85393945
30MP0004145_abnormal_muscle_electrophysio1.81935369
31MP0002127_abnormal_cardiovascular_syste1.70421927
32MP0004233_abnormal_muscle_weight1.62919866
33MP0003950_abnormal_plasma_membrane1.54085151
34MP0006036_abnormal_mitochondrial_physio1.52815664
35MP0005666_abnormal_adipose_tissue1.40377516
36MP0005670_abnormal_white_adipose1.34030574
37MP0003567_abnormal_fetal_cardiomyocyte1.29375863
38MP0002332_abnormal_exercise_endurance1.26096528
39MP0003279_aneurysm1.22900159
40MP0010368_abnormal_lymphatic_system1.21041823
41MP0002234_abnormal_pharynx_morphology1.19675758
42MP0000343_altered_response_to1.16375445
43* MP0000266_abnormal_heart_morphology1.14859578
44MP0005165_increased_susceptibility_to1.14333039
45MP0005623_abnormal_meninges_morphology1.01213823
46MP0005375_adipose_tissue_phenotype0.99772629
47MP0006035_abnormal_mitochondrial_morpho0.91024999
48MP0004185_abnormal_adipocyte_glucose0.89354070
49MP0001661_extended_life_span0.88515605
50MP0002108_abnormal_muscle_morphology0.87339436
51MP0002128_abnormal_blood_circulation0.85281044
52MP0003566_abnormal_cell_adhesion0.81179057
53MP0000230_abnormal_systemic_arterial0.80321057
54MP0002909_abnormal_adrenal_gland0.78691965
55MP0001299_abnormal_eye_distance/0.76652959
56MP0005266_abnormal_metabolism0.75583123
57MP0003705_abnormal_hypodermis_morpholog0.74603009
58MP0005503_abnormal_tendon_morphology0.71805132
59MP0003941_abnormal_skin_development0.70536295
60MP0000767_abnormal_smooth_muscle0.68754205
61MP0008004_abnormal_stomach_pH0.67856028
62MP0000013_abnormal_adipose_tissue0.67723078
63MP0000733_abnormal_muscle_development0.67306137
64MP0000003_abnormal_adipose_tissue0.66109827
65MP0001879_abnormal_lymphatic_vessel0.64452532
66MP0010030_abnormal_orbit_morphology0.59161028
67MP0005187_abnormal_penis_morphology0.59035056
68MP0003091_abnormal_cell_migration0.56346741
69MP0004272_abnormal_basement_membrane0.55567280
70MP0008438_abnormal_cutaneous_collagen0.52628791
71MP0004043_abnormal_pH_regulation0.50498868
72MP0005409_darkened_coat_color0.48954226
73MP0002925_abnormal_cardiovascular_devel0.48537137
74MP0002971_abnormal_brown_adipose0.47632305
75MP0005451_abnormal_body_composition0.46711440
76MP0005319_abnormal_enzyme/_coenzyme0.44120127
77MP0000762_abnormal_tongue_morphology0.43989956
78MP0008961_abnormal_basal_metabolism0.43841517
79MP0002078_abnormal_glucose_homeostasis0.43285281
80MP0003806_abnormal_nucleotide_metabolis0.42004521
81MP0003984_embryonic_growth_retardation0.40925527
82MP0009780_abnormal_chondrocyte_physiolo0.39918534
83MP0002088_abnormal_embryonic_growth/wei0.39537283
84MP0004147_increased_porphyrin_level0.38675011
85MP0004270_analgesia0.38125162
86MP0001784_abnormal_fluid_regulation0.37508216
87MP0001614_abnormal_blood_vessel0.37275665
88MP0005275_abnormal_skin_tensile0.36980724
89MP0002254_reproductive_system_inflammat0.35851291
90MP0002822_catalepsy0.35485461
91MP0005386_behavior/neurological_phenoty0.35042294
92MP0004924_abnormal_behavior0.35042294
93MP0009384_cardiac_valve_regurgitation0.33482020
94MP0003948_abnormal_gas_homeostasis0.32838279
95MP0005535_abnormal_body_temperature0.31281727
96MP0003045_fibrosis0.30741878
97MP0002090_abnormal_vision0.30561363
98MP0001542_abnormal_bone_strength0.29651403
99MP0001958_emphysema0.28948187
100MP0005595_abnormal_vascular_smooth0.27417297
101MP0001730_embryonic_growth_arrest0.26916398
102MP0005167_abnormal_blood-brain_barrier0.26877844
103MP0002877_abnormal_melanocyte_morpholog0.26166570
104MP0001915_intracranial_hemorrhage0.24028693
105MP0009840_abnormal_foam_cell0.23514522
106MP0002295_abnormal_pulmonary_circulatio0.23191224
107MP0001984_abnormal_olfaction0.22982774
108MP0005334_abnormal_fat_pad0.22508128
109MP0009115_abnormal_fat_cell0.21596356
110MP0002133_abnormal_respiratory_system0.21104709
111MP0005388_respiratory_system_phenotype0.21104709
112MP0001727_abnormal_embryo_implantation0.20886898
113MP0002118_abnormal_lipid_homeostasis0.20357102
114MP0000249_abnormal_blood_vessel0.20351886
115MP0008874_decreased_physiological_sensi0.20302448
116MP0005380_embryogenesis_phenotype0.20143512
117MP0001672_abnormal_embryogenesis/_devel0.20143512
118MP0002896_abnormal_bone_mineralization0.20062574
119MP0003935_abnormal_craniofacial_develop0.18208451
120MP0005023_abnormal_wound_healing0.18074259
121MP0000579_abnormal_nail_morphology0.17881389

Predicted human phenotypes

RankGene SetZ-score
1* Sudden death (HP:0001699)8.26344496
2Ventricular tachycardia (HP:0004756)7.56515241
3* Atrial fibrillation (HP:0005110)6.46731698
4Calf muscle hypertrophy (HP:0008981)6.45936375
5Muscle fiber splitting (HP:0003555)6.05890848
6* Primary atrial arrhythmia (HP:0001692)6.04760217
7* Supraventricular tachycardia (HP:0004755)5.83802380
8Muscle hypertrophy of the lower extremities (HP:0008968)5.75251358
9* Supraventricular arrhythmia (HP:0005115)5.72592300
10Right ventricular cardiomyopathy (HP:0011663)5.72151430
11Abnormality of the calf musculature (HP:0001430)5.61686557
12* Lipoatrophy (HP:0100578)5.54643941
13Exercise-induced muscle cramps (HP:0003710)5.33171320
14Exercise-induced myalgia (HP:0003738)5.29885143
15Hyporeflexia of lower limbs (HP:0002600)5.27495533
16Subaortic stenosis (HP:0001682)5.18375731
17Abnormality of the left ventricular outflow tract (HP:0011103)5.18375731
18* Syncope (HP:0001279)4.94862494
19* Dilated cardiomyopathy (HP:0001644)4.58475529
20Myoglobinuria (HP:0002913)4.54328301
21EMG: myopathic abnormalities (HP:0003458)4.29803553
22* Prolonged QT interval (HP:0001657)4.10036740
23Increased connective tissue (HP:0009025)4.06953590
24Asymmetric septal hypertrophy (HP:0001670)4.06605009
25* Ventricular arrhythmia (HP:0004308)4.05558633
26* Palpitations (HP:0001962)3.98340684
27Difficulty running (HP:0009046)3.59713827
28Centrally nucleated skeletal muscle fibers (HP:0003687)3.44588934
29* Bundle branch block (HP:0011710)3.41125069
30Myotonia (HP:0002486)3.40672474
31* Heart block (HP:0012722)3.39723228
32Rhabdomyolysis (HP:0003201)3.37472174
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.29574060
34* Abnormal atrioventricular conduction (HP:0005150)3.21433558
35Difficulty climbing stairs (HP:0003551)3.21371038
36Hypoplastic heart (HP:0001961)3.10470777
37Aplasia of the musculature (HP:0100854)3.05141363
38* Abnormal EKG (HP:0003115)3.03585180
39Nemaline bodies (HP:0003798)3.03195036
40* Atrioventricular block (HP:0001678)2.98721128
41Muscle fiber inclusion bodies (HP:0100299)2.94503353
42Testicular atrophy (HP:0000029)2.84511703
43Abnormal mitochondria in muscle tissue (HP:0008316)2.83129171
44Ketoacidosis (HP:0001993)2.81911693
45Hepatic necrosis (HP:0002605)2.80835428
46* Left ventricular hypertrophy (HP:0001712)2.79445023
47Acute necrotizing encephalopathy (HP:0006965)2.78365404
48Hypoplastic left heart (HP:0004383)2.76162530
49* Palmoplantar keratoderma (HP:0000982)2.70733814
50* Ventricular fibrillation (HP:0001663)2.69804583
51Popliteal pterygium (HP:0009756)2.66515508
52Limb-girdle muscle atrophy (HP:0003797)2.63533337
53Rimmed vacuoles (HP:0003805)2.62925756
54Distal lower limb muscle weakness (HP:0009053)2.62619510
55Hypoglycemic coma (HP:0001325)2.57153493
56Increased variability in muscle fiber diameter (HP:0003557)2.57103027
57Fatigable weakness (HP:0003473)2.51153245
58Abnormality of the neuromuscular junction (HP:0003398)2.51153245
59Type 2 muscle fiber atrophy (HP:0003554)2.47351402
60Bulbar palsy (HP:0001283)2.43116756
61Hepatocellular necrosis (HP:0001404)2.42198709
62Areflexia of lower limbs (HP:0002522)2.38885916
63Acute encephalopathy (HP:0006846)2.38438758
64Abnormality of fatty-acid metabolism (HP:0004359)2.35279182
65Ragged-red muscle fibers (HP:0003200)2.33499145
66Conjunctival hamartoma (HP:0100780)2.31706558
67Progressive macrocephaly (HP:0004481)2.31627111
68Increased muscle lipid content (HP:0009058)2.31269832
69Dicarboxylic aciduria (HP:0003215)2.29977309
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29977309
71Dysmetric saccades (HP:0000641)2.28979467
72Muscle fiber atrophy (HP:0100295)2.28877216
73Abnormality of skeletal muscle fiber size (HP:0012084)2.26991164
74Distal lower limb amyotrophy (HP:0008944)2.26675147
75Weak cry (HP:0001612)2.26565239
76Cerebral edema (HP:0002181)2.25397324
77Abnormality of the foot musculature (HP:0001436)2.25340531
78Mitochondrial inheritance (HP:0001427)2.23260493
79Neck muscle weakness (HP:0000467)2.22112494
80Mildly elevated creatine phosphokinase (HP:0008180)2.18046435
81* Sudden cardiac death (HP:0001645)2.17818649
82Pheochromocytoma (HP:0002666)2.16100243
83Hypoplastic ischia (HP:0003175)2.15120340
84Gowers sign (HP:0003391)2.14424512
85Steppage gait (HP:0003376)2.12137335
86Foot dorsiflexor weakness (HP:0009027)2.11277380
87Increased CSF lactate (HP:0002490)2.09877149
88Muscle stiffness (HP:0003552)2.07416949
89Large for gestational age (HP:0001520)2.07056278
90Respiratory insufficiency due to muscle weakness (HP:0002747)2.05221917
91Hamartoma of the eye (HP:0010568)2.02790906
92* Congestive heart failure (HP:0001635)2.01821602
93Abnormality of the shoulder girdle musculature (HP:0001435)2.01518532
94Ketosis (HP:0001946)2.01212143
95Type 1 muscle fiber predominance (HP:0003803)1.99311814
96Respiratory failure (HP:0002878)1.98234450
97EMG: neuropathic changes (HP:0003445)1.97838334
98Increased intramyocellular lipid droplets (HP:0012240)1.96084461
99Hyperinsulinemic hypoglycemia (HP:0000825)1.95953075
100Lactic acidosis (HP:0003128)1.95909701
101Double outlet right ventricle (HP:0001719)1.94268682
102Congenital malformation of the right heart (HP:0011723)1.94268682
103Muscular dystrophy (HP:0003560)1.93555842
104Broad metatarsal (HP:0001783)1.93545444
105Easy fatigability (HP:0003388)1.93388764
106Generalized muscle weakness (HP:0003324)1.92886051
107Exercise intolerance (HP:0003546)1.92341332
108Neuroendocrine neoplasm (HP:0100634)1.90647724
109Scapular winging (HP:0003691)1.88935410
110Neoplasm of the adrenal gland (HP:0100631)1.88205693
111Central scotoma (HP:0000603)1.87903863
112Abnormality of the ischium (HP:0003174)1.86356771
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85237447
114Abnormality of alanine metabolism (HP:0010916)1.85237447
115Hyperalaninemia (HP:0003348)1.85237447
116Lower limb amyotrophy (HP:0007210)1.85143389
117Lymphangioma (HP:0100764)1.84930945
118Proximal amyotrophy (HP:0007126)1.84916864
119Thin ribs (HP:0000883)1.84826852
120Neoplasm of head and neck (HP:0012288)1.83117796
121Esophageal neoplasm (HP:0100751)1.83117796
122Amniotic constriction ring (HP:0009775)1.82789679
123Abnormality of placental membranes (HP:0011409)1.82789679
124Aneurysm (HP:0002617)1.81380397
125Aortic aneurysm (HP:0004942)1.79472218
126Skin nodule (HP:0200036)1.78967900
127Resting tremor (HP:0002322)1.77659788
128Generalized amyotrophy (HP:0003700)1.75702039
129Frequent falls (HP:0002359)1.73540269
130Progressive muscle weakness (HP:0003323)1.72190091
131Fetal akinesia sequence (HP:0001989)1.69753572
132Pterygium (HP:0001059)1.66568555
133Malignant hyperthermia (HP:0002047)1.65724815
134Hip contracture (HP:0003273)1.64798330
135Pulmonary artery stenosis (HP:0004415)1.62462974
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58126083
137Aplasia/Hypoplasia involving the musculature (HP:0001460)1.56422771
138Increased serum pyruvate (HP:0003542)1.53650599
139Round ear (HP:0100830)1.53246895
140Preauricular pit (HP:0004467)1.50975174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.64707542
2LMTK24.33837211
3PHKG13.92787990
4PHKG23.92787990
5MYLK3.92199370
6OBSCN3.58630903
7PDK43.34726815
8PDK33.34726815
9PKN23.28778089
10DMPK3.27027895
11TRIB33.02867582
12MUSK2.94511325
13BCKDK2.28912847
14PIK3CA2.20139440
15TIE12.11205332
16LIMK12.01371080
17NEK12.00933558
18PDK21.95757663
19PINK11.89165482
20STK241.84067065
21PAK31.71299619
22GRK71.66237843
23PRKD11.45756316
24MAP3K61.38449191
25ILK1.28068441
26MOS1.25044909
27MARK11.19120006
28ROCK11.11991776
29WNK41.10600380
30STK41.08987263
31CDC42BPA1.06685942
32RIPK11.04247748
33* CAMK2D1.03366917
34MAPK120.97097847
35MAP3K70.96306264
36INSRR0.94942637
37PIK3CG0.94741468
38MAPKAPK30.89788440
39MAP3K50.89462011
40PDGFRA0.88236433
41PRKAA10.86825595
42CAMK40.82559354
43TRPM70.81246326
44PKN10.81060636
45DAPK30.81013132
46STK380.80284079
47STK38L0.78948999
48ZAK0.77631655
49PRKAA20.77437567
50FLT30.77398587
51ROCK20.75443017
52EPHB10.75173810
53CAMK2A0.71484665
54WNK10.69213172
55PTK20.68264880
56RPS6KL10.66363570
57RPS6KC10.66363570
58ICK0.64192436
59KDR0.63266030
60TGFBR20.61210001
61CAMK2B0.59550450
62CAMK10.56546459
63RPS6KA60.56375316
64PTK2B0.55596310
65PRKCE0.54406509
66PRKACB0.52674619
67MAP2K30.50952472
68TESK10.49066650
69MET0.47442261
70MAP3K30.45264002
71MAPK40.45018412
72EEF2K0.44479245
73PDPK10.43845333
74PRKACG0.43684971
75PAK20.43467184
76STK390.42968815
77PRKACA0.42241809
78SIK10.40529145
79AKT20.40059437
80PTK60.39467957
81PRKCH0.39003358
82PRKD30.38638118
83CAMK2G0.36115093
84PAK40.35843807
85FER0.34742450
86PDK10.34132001
87RET0.33302343
88LATS20.32192447
89MTOR0.31940652
90UHMK10.30432688
91RPS6KA10.30358467
92EPHB20.29784445
93SCYL20.26506277
94MELK0.25091504
95SGK30.24926906
96MAPK100.24530752
97PRKG20.24467659
98JAK10.24342612
99FGFR40.23877129
100ERBB40.23307303
101PAK60.22761989
102NEK90.22733245
103LATS10.22162975
104RPS6KA20.21844372
105KSR20.21502974
106EPHA30.20191185
107ITK0.18817813
108RPS6KA30.18357050
109DDR20.18185308
110PDGFRB0.18028498
111PRKG10.17823447
112AKT10.17452786
113MAPK90.16983176
114SGK10.16438886
115MAP3K100.16350277
116LRRK20.15324893
117AURKB0.15313136
118CAMK1D0.15257827
119TAOK10.15029248
120MAPK70.14867166
121MAP3K40.14839860
122STK30.14712219
123NME20.13860372
124MAP2K10.13724094
125STK110.13638276

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.74493487
2Cardiac muscle contraction_Homo sapiens_hsa042604.33220623
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.23559507
4Dilated cardiomyopathy_Homo sapiens_hsa054144.01551908
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.81271136
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50432030
7Propanoate metabolism_Homo sapiens_hsa006403.10436428
8Parkinsons disease_Homo sapiens_hsa050122.98686663
9Oxidative phosphorylation_Homo sapiens_hsa001902.86516828
10Fatty acid degradation_Homo sapiens_hsa000712.82012839
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.61621960
12Carbon metabolism_Homo sapiens_hsa012002.31935006
13Alzheimers disease_Homo sapiens_hsa050102.20865172
14Fatty acid metabolism_Homo sapiens_hsa012122.15629196
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14334709
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99668026
17Viral myocarditis_Homo sapiens_hsa054161.89167995
18Huntingtons disease_Homo sapiens_hsa050161.83483067
19* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76915776
20Pyruvate metabolism_Homo sapiens_hsa006201.66076456
21Butanoate metabolism_Homo sapiens_hsa006501.41122873
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32243732
23Fatty acid elongation_Homo sapiens_hsa000621.20236372
24cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07406807
25PPAR signaling pathway_Homo sapiens_hsa033201.06782153
26Insulin resistance_Homo sapiens_hsa049311.05649484
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04993287
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03333667
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.00758480
30Biosynthesis of amino acids_Homo sapiens_hsa012300.97640611
31Glucagon signaling pathway_Homo sapiens_hsa049220.97222249
32Insulin signaling pathway_Homo sapiens_hsa049100.89064645
33Lysine degradation_Homo sapiens_hsa003100.87966556
34Starch and sucrose metabolism_Homo sapiens_hsa005000.86834382
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80872966
36Type II diabetes mellitus_Homo sapiens_hsa049300.80619220
37Tryptophan metabolism_Homo sapiens_hsa003800.80418863
38Calcium signaling pathway_Homo sapiens_hsa040200.78942741
39Arginine biosynthesis_Homo sapiens_hsa002200.77722413
40Focal adhesion_Homo sapiens_hsa045100.75631136
41beta-Alanine metabolism_Homo sapiens_hsa004100.69895584
42HIF-1 signaling pathway_Homo sapiens_hsa040660.69058473
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66744922
44AMPK signaling pathway_Homo sapiens_hsa041520.66734308
45Oxytocin signaling pathway_Homo sapiens_hsa049210.64312239
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.61978279
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61320589
48Fatty acid biosynthesis_Homo sapiens_hsa000610.59460549
49Arginine and proline metabolism_Homo sapiens_hsa003300.58828332
50cAMP signaling pathway_Homo sapiens_hsa040240.57601924
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56946508
52ECM-receptor interaction_Homo sapiens_hsa045120.55763817
53Renin secretion_Homo sapiens_hsa049240.55094077
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55052770
55Tight junction_Homo sapiens_hsa045300.52798217
56Insulin secretion_Homo sapiens_hsa049110.52559728
57Prion diseases_Homo sapiens_hsa050200.51571429
58Melanogenesis_Homo sapiens_hsa049160.48935018
59Gastric acid secretion_Homo sapiens_hsa049710.48370364
60Sulfur relay system_Homo sapiens_hsa041220.48142002
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.46699853
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46191671
63Phenylalanine metabolism_Homo sapiens_hsa003600.45551959
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44782056
65Hippo signaling pathway_Homo sapiens_hsa043900.43929456
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42228514
67Circadian entrainment_Homo sapiens_hsa047130.41289069
68Adherens junction_Homo sapiens_hsa045200.40538054
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39473890
70Galactose metabolism_Homo sapiens_hsa000520.39228640
71Amoebiasis_Homo sapiens_hsa051460.37859459
72Peroxisome_Homo sapiens_hsa041460.37497009
73Dorso-ventral axis formation_Homo sapiens_hsa043200.37083122
74Thyroid hormone synthesis_Homo sapiens_hsa049180.34940418
75Endometrial cancer_Homo sapiens_hsa052130.34498780
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33851601
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.32793142
78GABAergic synapse_Homo sapiens_hsa047270.32379492
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30923229
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29000018
81Melanoma_Homo sapiens_hsa052180.28678211
82Olfactory transduction_Homo sapiens_hsa047400.27878724
83Taste transduction_Homo sapiens_hsa047420.26777726
84Oocyte meiosis_Homo sapiens_hsa041140.26760875
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25936819
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25668088
87Renal cell carcinoma_Homo sapiens_hsa052110.25399382
88Ovarian steroidogenesis_Homo sapiens_hsa049130.25074826
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24768227
90Cocaine addiction_Homo sapiens_hsa050300.24532856
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24429525
92Fructose and mannose metabolism_Homo sapiens_hsa000510.23472477
93Gap junction_Homo sapiens_hsa045400.23192448
94Pathways in cancer_Homo sapiens_hsa052000.22200800
95Cholinergic synapse_Homo sapiens_hsa047250.22195083
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21909918
97Amphetamine addiction_Homo sapiens_hsa050310.21539836
98Proteoglycans in cancer_Homo sapiens_hsa052050.21507497
99Pentose phosphate pathway_Homo sapiens_hsa000300.20515177
100GnRH signaling pathway_Homo sapiens_hsa049120.20119449
101FoxO signaling pathway_Homo sapiens_hsa040680.19085432
102Circadian rhythm_Homo sapiens_hsa047100.18856315
103Platelet activation_Homo sapiens_hsa046110.18320115
104VEGF signaling pathway_Homo sapiens_hsa043700.17480126
105Protein digestion and absorption_Homo sapiens_hsa049740.17466578
106Rap1 signaling pathway_Homo sapiens_hsa040150.16877461
107mTOR signaling pathway_Homo sapiens_hsa041500.16584611
108Pancreatic secretion_Homo sapiens_hsa049720.16215105
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.15831657
110Metabolic pathways_Homo sapiens_hsa011000.15456868
111Bile secretion_Homo sapiens_hsa049760.14387266
112Estrogen signaling pathway_Homo sapiens_hsa049150.14192359
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.11839042
114Notch signaling pathway_Homo sapiens_hsa043300.11676993
115Fat digestion and absorption_Homo sapiens_hsa049750.11385774
116Salivary secretion_Homo sapiens_hsa049700.09133181
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.08514654
118Small cell lung cancer_Homo sapiens_hsa052220.08106463
119Toxoplasmosis_Homo sapiens_hsa051450.06435243
120Morphine addiction_Homo sapiens_hsa050320.06228649
121Tyrosine metabolism_Homo sapiens_hsa003500.05541124

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