SCN7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)4.98719405
2negative regulation of dendrite morphogenesis (GO:0050774)4.88108432
3regulation of cholesterol esterification (GO:0010872)4.66836932
4cellular ketone body metabolic process (GO:0046950)4.65397714
5membrane assembly (GO:0071709)4.64040193
6peripheral nervous system neuron development (GO:0048935)4.63441832
7cell migration in hindbrain (GO:0021535)4.24943354
8detection of temperature stimulus (GO:0016048)4.21697370
9phospholipid efflux (GO:0033700)4.09861961
10ketone body metabolic process (GO:1902224)4.06837652
11high-density lipoprotein particle remodeling (GO:0034375)4.06025184
12detection of temperature stimulus involved in sensory perception (GO:0050961)3.97567452
13detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.97567452
14positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.91767544
15cardiac myofibril assembly (GO:0055003)3.86511550
16muscle filament sliding (GO:0030049)3.77881217
17actin-myosin filament sliding (GO:0033275)3.77881217
18negative regulation of homotypic cell-cell adhesion (GO:0034111)3.77437669
19myofibril assembly (GO:0030239)3.76383165
20reverse cholesterol transport (GO:0043691)3.74687404
21calcium-mediated signaling using intracellular calcium source (GO:0035584)3.69317892
22membrane raft organization (GO:0031579)3.65006794
23retina vasculature morphogenesis in camera-type eye (GO:0061299)3.53600193
24actin-mediated cell contraction (GO:0070252)3.52080992
25blood vessel maturation (GO:0001955)3.51222176
26regulation of relaxation of muscle (GO:1901077)3.48707075
27sarcomere organization (GO:0045214)3.43595824
28regulation of skeletal muscle contraction (GO:0014819)3.43300330
29low-density lipoprotein particle clearance (GO:0034383)3.39445036
30protein targeting to plasma membrane (GO:0072661)3.36531543
31negative regulation of platelet activation (GO:0010544)3.34288478
32neuronal action potential propagation (GO:0019227)3.34254065
33plasma membrane repair (GO:0001778)3.30151106
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.29549281
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.29462944
36plasma lipoprotein particle assembly (GO:0034377)3.25756427
37ovulation from ovarian follicle (GO:0001542)3.22335986
38phospholipid homeostasis (GO:0055091)3.20621304
39regulation of actin filament-based movement (GO:1903115)3.19683562
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.19594246
41fatty acid transmembrane transport (GO:1902001)3.19127688
42proline transport (GO:0015824)3.17484319
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.15301750
44serotonin receptor signaling pathway (GO:0007210)3.12458638
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.10657819
46positive regulation of axon extension (GO:0045773)3.10148462
47negative regulation of calcium ion transport into cytosol (GO:0010523)3.09122117
48neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.09041715
49negative regulation of lipase activity (GO:0060192)3.06810522
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04572724
51surfactant homeostasis (GO:0043129)3.04333279
52relaxation of cardiac muscle (GO:0055119)3.00204796
53positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.99208038
54regulation of cell communication by electrical coupling (GO:0010649)2.98680595
55peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.98441185
56negative regulation of dendrite development (GO:2000171)2.98413313
57otic vesicle formation (GO:0030916)2.94539144
58embryonic digestive tract morphogenesis (GO:0048557)2.93384767
59negative regulation of nitric-oxide synthase activity (GO:0051001)2.92181788
60regulation of cAMP-dependent protein kinase activity (GO:2000479)2.89696093
61carnitine shuttle (GO:0006853)2.89158859
62innervation (GO:0060384)2.87335509
63negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.86518250
64phasic smooth muscle contraction (GO:0014821)2.86359590
65regulation of cytokine secretion involved in immune response (GO:0002739)2.85682707
66negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.85632620
67regulation of striated muscle contraction (GO:0006942)2.85036740
68chemical homeostasis within a tissue (GO:0048875)2.85035250
69regulation of platelet aggregation (GO:0090330)2.84860762
70regulation of heterotypic cell-cell adhesion (GO:0034114)2.83488000
71sarcoplasmic reticulum calcium ion transport (GO:0070296)2.82941215
72protein-lipid complex assembly (GO:0065005)2.82297689
73regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82083615
74plasma lipoprotein particle remodeling (GO:0034369)2.81028235
75protein-lipid complex remodeling (GO:0034368)2.81028235
76macromolecular complex remodeling (GO:0034367)2.81028235
77hemidesmosome assembly (GO:0031581)2.80527498
78cell communication involved in cardiac conduction (GO:0086065)2.78464361
79regulation of glycogen (starch) synthase activity (GO:2000465)2.78176085
80negative regulation of protein activation cascade (GO:2000258)2.75855745
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.75423338
82glomerular filtration (GO:0003094)2.75122260
83lung vasculature development (GO:0060426)2.72929417
84regulation of vasculogenesis (GO:2001212)2.72336083
85negative regulation of protein autophosphorylation (GO:0031953)2.72297280
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71387174
87membrane budding (GO:0006900)2.71175022
88cholesterol efflux (GO:0033344)2.70984465
89cardiac muscle hypertrophy (GO:0003300)2.70882651
90actomyosin structure organization (GO:0031032)2.70373640
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69162920
92detection of mechanical stimulus involved in sensory perception (GO:0050974)2.68234937
93inositol phosphate catabolic process (GO:0071545)2.67822940
94tachykinin receptor signaling pathway (GO:0007217)2.67820749
95galactose catabolic process (GO:0019388)2.67771336
96positive regulation of glomerulus development (GO:0090193)2.66098848
97cardiac muscle contraction (GO:0060048)2.65782085
98growth hormone receptor signaling pathway (GO:0060396)2.65291246
99negative regulation of endothelial cell proliferation (GO:0001937)2.64612393
100negative regulation of endothelial cell apoptotic process (GO:2000352)2.64435762
101renal filtration (GO:0097205)2.64055496
102negative regulation of DNA biosynthetic process (GO:2000279)2.64039817
103response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.63871080
104negative regulation of protein localization to cell surface (GO:2000009)2.62929699
105triglyceride catabolic process (GO:0019433)2.62915265
106positive regulation of muscle hypertrophy (GO:0014742)2.62450969
107positive regulation of cardiac muscle hypertrophy (GO:0010613)2.62450969
108nephron epithelium morphogenesis (GO:0072088)2.62378506
109nephron tubule morphogenesis (GO:0072078)2.62378506
110hypotonic response (GO:0006971)2.61790794
111regulation of cardiac muscle cell contraction (GO:0086004)2.61426852
112regulation of digestive system process (GO:0044058)2.61126287
113carnitine transport (GO:0015879)2.60303816
114amino-acid betaine transport (GO:0015838)2.60303816
115one-carbon compound transport (GO:0019755)2.59096734
116regulation of cardiac muscle contraction (GO:0055117)2.58726186
117plasma lipoprotein particle clearance (GO:0034381)2.57838641
118toxin metabolic process (GO:0009404)2.56714698
119striated muscle hypertrophy (GO:0014897)2.56482195
120valine metabolic process (GO:0006573)2.55721260
121endocrine hormone secretion (GO:0060986)2.55439405
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54775854
123axon extension (GO:0048675)2.54277167
124establishment of mitochondrion localization (GO:0051654)2.54261413
125bile acid biosynthetic process (GO:0006699)2.53751709
126cardiac muscle cell development (GO:0055013)2.53413384
127positive regulation of vasculogenesis (GO:2001214)2.52639324
128long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.52506439
129artery development (GO:0060840)2.52401068
130negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.52219423
131respiratory tube development (GO:0030323)2.51312080
132regulation of sodium ion transmembrane transport (GO:1902305)2.51298254
133response to inactivity (GO:0014854)2.50566885
134intermediate filament organization (GO:0045109)2.50550556
135negative regulation of sodium ion transport (GO:0010766)2.50403420
136* neuronal action potential (GO:0019228)2.49642758
137relaxation of muscle (GO:0090075)2.49627914
138regulation of action potential (GO:0098900)2.49398256
139mammary gland development (GO:0030879)2.48972186
140negative regulation of cation channel activity (GO:2001258)2.46805394
141brown fat cell differentiation (GO:0050873)2.46619507
142retinal ganglion cell axon guidance (GO:0031290)2.46472656
143regulation of sodium ion transmembrane transporter activity (GO:2000649)2.46161257
144regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.46083139
145regulation of membrane repolarization (GO:0060306)2.45829807
146somite development (GO:0061053)2.45655360
147negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45471065
148endothelial cell differentiation (GO:0045446)2.45175652
149regulation of cardiac muscle hypertrophy (GO:0010611)2.45157375
150striated muscle contraction (GO:0006941)2.43684680
151galactose metabolic process (GO:0006012)2.43478769
152interkinetic nuclear migration (GO:0022027)2.43423218
153establishment of monopolar cell polarity (GO:0061162)2.43028587
154establishment or maintenance of monopolar cell polarity (GO:0061339)2.43028587
155actin filament-based movement (GO:0030048)2.42781555
156regulation of hippo signaling (GO:0035330)2.42610476
157regulation of NFAT protein import into nucleus (GO:0051532)2.42480071
158SMAD protein signal transduction (GO:0060395)2.42330120
159renal tubule morphogenesis (GO:0061333)2.42049745
160cardiac muscle tissue morphogenesis (GO:0055008)2.41985542
161prostate gland growth (GO:0060736)2.41176128
162regulation of muscle hypertrophy (GO:0014743)2.40679737
163establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.39836169
164mitochondrion transport along microtubule (GO:0047497)2.39836169
165acylglycerol catabolic process (GO:0046464)2.39766703
166neutral lipid catabolic process (GO:0046461)2.39766703
167long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.39672404
168response to vitamin E (GO:0033197)2.39229614
169muscle tissue morphogenesis (GO:0060415)2.38336588
170suckling behavior (GO:0001967)2.37809047
171cGMP-mediated signaling (GO:0019934)2.35929266
172regulation of metalloenzyme activity (GO:0048552)2.35540689
173cardiac muscle cell action potential (GO:0086001)2.35237694
174positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35143155
175ventricular cardiac muscle cell action potential (GO:0086005)2.34060472
176triglyceride biosynthetic process (GO:0019432)2.33907299
177regulation of protein kinase A signaling (GO:0010738)2.32941281
178negative regulation of systemic arterial blood pressure (GO:0003085)2.32673408
179regulation of cholesterol storage (GO:0010885)2.32389283
180intracellular lipid transport (GO:0032365)2.31974008
181vascular endothelial growth factor signaling pathway (GO:0038084)2.27859441
182positive regulation of fatty acid oxidation (GO:0046321)2.27789355
183negative regulation of nitric oxide biosynthetic process (GO:0045019)2.27702333
184lymphangiogenesis (GO:0001946)2.27637734
185lung lobe morphogenesis (GO:0060463)2.27122710
186fatty-acyl-CoA biosynthetic process (GO:0046949)2.27054221
187cell communication by electrical coupling (GO:0010644)2.26881303
188neutral lipid biosynthetic process (GO:0046460)2.25540625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.19913716
2GBX2_23144817_ChIP-Seq_PC3_Human2.54026068
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40250781
4VDR_22108803_ChIP-Seq_LS180_Human2.37569246
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.36590138
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29154320
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22565967
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22363274
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20560460
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14261822
11GATA1_22025678_ChIP-Seq_K562_Human2.08640615
12TAF15_26573619_Chip-Seq_HEK293_Human2.06407098
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06390803
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03587464
15ZNF274_21170338_ChIP-Seq_K562_Hela2.03438440
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.02095314
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00972027
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00972027
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96671047
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95735140
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.95371099
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.95305561
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82880075
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.82232064
25CJUN_26792858_Chip-Seq_BT549_Human1.81098602
26AHR_22903824_ChIP-Seq_MCF-7_Human1.80547871
27* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75962285
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.75539124
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73397316
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70214656
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69503960
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69111289
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68039008
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66964509
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64882700
36CLOCK_20551151_ChIP-Seq_293T_Human1.64659212
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.60727206
38FUS_26573619_Chip-Seq_HEK293_Human1.60564271
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.59194021
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58204321
41IGF1R_20145208_ChIP-Seq_DFB_Human1.57949523
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57136937
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.55823727
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55750736
45SMAD4_21799915_ChIP-Seq_A2780_Human1.53366585
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53236753
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.48131103
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47587751
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.47220733
50PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.47025370
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46792219
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45553829
53AR_21572438_ChIP-Seq_LNCaP_Human1.42721429
54BCAT_22108803_ChIP-Seq_LS180_Human1.41044830
55TCF4_23295773_ChIP-Seq_U87_Human1.40920865
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40548168
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.39052509
58ER_23166858_ChIP-Seq_MCF-7_Human1.37725334
59EZH2_22144423_ChIP-Seq_EOC_Human1.37178559
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37039303
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36397501
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36249574
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36249574
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.35974313
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35371102
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.35040387
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34932731
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30478122
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30305163
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28959344
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28763738
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.24459364
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.24247338
74P300_19829295_ChIP-Seq_ESCs_Human1.23834765
75SMAD3_21741376_ChIP-Seq_HESCs_Human1.23501228
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23059080
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.22879201
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22345188
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21207701
80TP53_18474530_ChIP-ChIP_U2OS_Human1.20583044
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.20538130
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19525788
83CBP_20019798_ChIP-Seq_JUKART_Human1.18830750
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18830750
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18363786
86STAT3_23295773_ChIP-Seq_U87_Human1.18300996
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17866602
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17603377
89TP53_16413492_ChIP-PET_HCT116_Human1.17551765
90ZNF263_19887448_ChIP-Seq_K562_Human1.16059271
91AR_25329375_ChIP-Seq_VCAP_Human1.15385980
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13875721
93SOX2_20726797_ChIP-Seq_SW620_Human1.13772752
94RUNX2_22187159_ChIP-Seq_PCA_Human1.12593175
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11654829
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11316846
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09929821
98ESR1_21235772_ChIP-Seq_MCF-7_Human1.09564824
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09402720
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09304780
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08997418
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08433216
103CDX2_22108803_ChIP-Seq_LS180_Human1.08182153
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08166078
105* NANOG_19829295_ChIP-Seq_ESCs_Human1.08146123
106* SOX2_19829295_ChIP-Seq_ESCs_Human1.08146123
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07643771
108RNF2_27304074_Chip-Seq_NSC_Mouse1.07126300
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.06094504
110* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05646204
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05454600
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05124741
113* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04993161
114EWS_26573619_Chip-Seq_HEK293_Human1.04980187
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04703578
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04469402
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04277065
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03929085
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03841852
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02606909
121* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02535551
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01581718
123* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01481054
124* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01307404
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00929579
126* TAL1_26923725_Chip-Seq_HPCs_Mouse1.00841136
127RXR_22108803_ChIP-Seq_LS180_Human0.97705399
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97625706
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96997484
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96775447
131* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96652630
132KDM2B_26808549_Chip-Seq_K562_Human0.95747391
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.94724816
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93800501
135TP63_23658742_ChIP-Seq_EP156T_Human0.93547115
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93510468
137* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93398226
138VDR_24787735_ChIP-Seq_THP-1_Human0.91373519
139DROSHA_22980978_ChIP-Seq_HELA_Human0.90283573
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89762367
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88342471
142KDM2B_26808549_Chip-Seq_REH_Human0.88279514
143* TCF4_22108803_ChIP-Seq_LS180_Human0.87731021
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87639314
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.87591284
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.87591284
147EGR1_19032775_ChIP-ChIP_M12_Human0.85497402
148* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84940015
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84204729
150* TCF4_18268006_ChIP-ChIP_LS174T_Human0.83549311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.38780686
2MP0002735_abnormal_chemical_nociception4.18249539
3MP0003191_abnormal_cellular_cholesterol3.88099843
4MP0004858_abnormal_nervous_system3.87430453
5MP0008438_abnormal_cutaneous_collagen3.86244896
6MP0003705_abnormal_hypodermis_morpholog3.30610778
7MP0003045_fibrosis2.99666183
8MP0002837_dystrophic_cardiac_calcinosis2.95626486
9MP0005275_abnormal_skin_tensile2.94510246
10MP0004270_analgesia2.91467977
11MP0005670_abnormal_white_adipose2.88720148
12MP0003950_abnormal_plasma_membrane2.87232973
13MP0004147_increased_porphyrin_level2.84118419
14MP0004272_abnormal_basement_membrane2.78513540
15MP0004145_abnormal_muscle_electrophysio2.65915797
16MP0003646_muscle_fatigue2.64582334
17MP0001968_abnormal_touch/_nociception2.57195122
18MP0008995_early_reproductive_senescence2.42621496
19MP0006276_abnormal_autonomic_nervous2.33791698
20MP0002736_abnormal_nociception_after2.27749615
21MP0000751_myopathy2.24027030
22MP0005360_urolithiasis2.19067766
23MP0009840_abnormal_foam_cell2.16949538
24MP0002734_abnormal_mechanical_nocicepti2.08734511
25MP0004130_abnormal_muscle_cell2.02821353
26MP0003828_pulmonary_edema1.94990285
27MP0001879_abnormal_lymphatic_vessel1.88909751
28MP0002733_abnormal_thermal_nociception1.86124355
29MP0010368_abnormal_lymphatic_system1.83998628
30MP0000013_abnormal_adipose_tissue1.79252094
31MP0001958_emphysema1.77218695
32MP0000749_muscle_degeneration1.75853653
33MP0002332_abnormal_exercise_endurance1.73513234
34MP0006054_spinal_hemorrhage1.71375165
35MP0003137_abnormal_impulse_conducting1.64885378
36MP0005666_abnormal_adipose_tissue1.56055580
37MP0003724_increased_susceptibility_to1.55096324
38MP0002106_abnormal_muscle_physiology1.51555561
39MP0005369_muscle_phenotype1.50532512
40MP0003136_yellow_coat_color1.50075628
41MP0006138_congestive_heart_failure1.48465022
42MP0005551_abnormal_eye_electrophysiolog1.46941479
43MP0002638_abnormal_pupillary_reflex1.46265648
44MP0001970_abnormal_pain_threshold1.45096060
45MP0002127_abnormal_cardiovascular_syste1.45028368
46MP0001984_abnormal_olfaction1.40983490
47MP0000750_abnormal_muscle_regeneration1.38995863
48MP0005503_abnormal_tendon_morphology1.36934291
49MP0002876_abnormal_thyroid_physiology1.34939367
50MP0004883_abnormal_blood_vessel1.34875111
51MP0009384_cardiac_valve_regurgitation1.34868724
52MP0002102_abnormal_ear_morphology1.33665728
53MP0002168_other_aberrant_phenotype1.32168841
54MP0005385_cardiovascular_system_phenoty1.28681259
55MP0001544_abnormal_cardiovascular_syste1.28681259
56MP0002972_abnormal_cardiac_muscle1.26710801
57MP0008775_abnormal_heart_ventricle1.24982043
58MP0002138_abnormal_hepatobiliary_system1.24292810
59MP0010030_abnormal_orbit_morphology1.23876667
60MP0008004_abnormal_stomach_pH1.18141719
61MP0003195_calcinosis1.13543777
62MP0003279_aneurysm1.13240282
63MP0001542_abnormal_bone_strength1.12894620
64MP0005375_adipose_tissue_phenotype1.11763753
65MP0008260_abnormal_autophagy1.11583587
66MP0005253_abnormal_eye_physiology1.09298736
67MP0002269_muscular_atrophy1.07398358
68MP0001348_abnormal_lacrimal_gland1.07205339
69MP0002067_abnormal_sensory_capabilities1.07037686
70MP0004036_abnormal_muscle_relaxation1.06826660
71MP0005620_abnormal_muscle_contractility1.06767101
72MP0005085_abnormal_gallbladder_physiolo1.05822165
73MP0005167_abnormal_blood-brain_barrier1.05766287
74MP0003566_abnormal_cell_adhesion1.04102948
75MP0004782_abnormal_surfactant_physiolog1.03528970
76MP0003329_amyloid_beta_deposits1.03480476
77MP0000383_abnormal_hair_follicle1.02837718
78MP0000462_abnormal_digestive_system1.02413338
79MP0003567_abnormal_fetal_cardiomyocyte1.01916919
80MP0004084_abnormal_cardiac_muscle1.01726156
81MP0002909_abnormal_adrenal_gland1.01614163
82MP0005535_abnormal_body_temperature1.00117982
83MP0001664_abnormal_digestion0.99292677
84MP0003011_delayed_dark_adaptation0.99032740
85MP0010386_abnormal_urinary_bladder0.98053101
86MP0004185_abnormal_adipocyte_glucose0.97169033
87MP0001486_abnormal_startle_reflex0.96882458
88MP0005171_absent_coat_pigmentation0.96384496
89MP0003283_abnormal_digestive_organ0.95452964
90MP0002272_abnormal_nervous_system0.95272462
91MP0009115_abnormal_fat_cell0.95224981
92MP0004484_altered_response_of0.94518978
93MP0004215_abnormal_myocardial_fiber0.94425786
94MP0002184_abnormal_innervation0.94094076
95MP0000343_altered_response_to0.93649185
96MP0002234_abnormal_pharynx_morphology0.93122079
97MP0005164_abnormal_response_to0.92585078
98MP0001756_abnormal_urination0.92029032
99MP0002938_white_spotting0.90894281
100MP0000681_abnormal_thyroid_gland0.90028793
101MP0004087_abnormal_muscle_fiber0.87516976
102MP0002133_abnormal_respiratory_system0.86108529
103MP0005388_respiratory_system_phenotype0.86108529
104MP0005330_cardiomyopathy0.85700383
105MP0000631_abnormal_neuroendocrine_gland0.85578026
106MP0002108_abnormal_muscle_morphology0.85302536
107MP0002971_abnormal_brown_adipose0.85084281
108MP0000230_abnormal_systemic_arterial0.84818813
109MP0009046_muscle_twitch0.84711255
110MP0005334_abnormal_fat_pad0.84564934
111MP0000003_abnormal_adipose_tissue0.84432041
112MP0000747_muscle_weakness0.83977368
113MP0003119_abnormal_digestive_system0.83637287
114MP0002128_abnormal_blood_circulation0.83636186
115MP0002009_preneoplasia0.83090190
116MP0003880_abnormal_central_pattern0.82066229
117MP0001177_atelectasis0.80502800
118MP0002295_abnormal_pulmonary_circulatio0.80380743
119MP0000759_abnormal_skeletal_muscle0.79935976
120MP0003690_abnormal_glial_cell0.79900743
121MP0003634_abnormal_glial_cell0.79886049
122MP0006072_abnormal_retinal_apoptosis0.79578699
123MP0001661_extended_life_span0.79474098
124MP0008877_abnormal_DNA_methylation0.79304467
125MP0010630_abnormal_cardiac_muscle0.79135012
126MP0004142_abnormal_muscle_tone0.78889753
127MP0001501_abnormal_sleep_pattern0.77127019
128MP0003252_abnormal_bile_duct0.76385675
129MP0000516_abnormal_urinary_system0.76273402
130MP0005367_renal/urinary_system_phenotyp0.76273402
131MP0002751_abnormal_autonomic_nervous0.75846188
132MP0003942_abnormal_urinary_system0.75211304
133MP0000920_abnormal_myelination0.74797323
134MP0005595_abnormal_vascular_smooth0.73757662
135MP0009250_abnormal_appendicular_skeleto0.73196247
136MP0005165_increased_susceptibility_to0.71832743
137MP0003091_abnormal_cell_migration0.71312226
138MP0001299_abnormal_eye_distance/0.71243645
139MP0004085_abnormal_heartbeat0.70767466
140MP0008569_lethality_at_weaning0.70174598
141MP0000767_abnormal_smooth_muscle0.67954732
142MP0004133_heterotaxia0.67697042
143MP0003633_abnormal_nervous_system0.65494258
144MP0010329_abnormal_lipoprotein_level0.65367335
145MP0001270_distended_abdomen0.64744137
146MP0004859_abnormal_synaptic_plasticity0.61057802
147MP0002166_altered_tumor_susceptibility0.60718123
148MP0004811_abnormal_neuron_physiology0.59407006
149MP0002118_abnormal_lipid_homeostasis0.59240214
150MP0000534_abnormal_ureter_morphology0.58167621
151MP0000604_amyloidosis0.58085513

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)7.16185270
2Growth hormone excess (HP:0000845)5.19379707
3Insidious onset (HP:0003587)4.73822805
4Termporal pattern (HP:0011008)4.73822805
5Action tremor (HP:0002345)4.63034157
6Segmental peripheral demyelination/remyelination (HP:0003481)4.61530208
7Pheochromocytoma (HP:0002666)4.38066209
8Sudden death (HP:0001699)4.01277522
9Chronic hepatic failure (HP:0100626)3.97683005
10Neuroendocrine neoplasm (HP:0100634)3.93485607
11Spontaneous abortion (HP:0005268)3.92447631
12Oligomenorrhea (HP:0000876)3.81550062
13Acanthosis nigricans (HP:0000956)3.66905643
14Bundle branch block (HP:0011710)3.65693635
15Myokymia (HP:0002411)3.58076014
16Calf muscle hypertrophy (HP:0008981)3.55327626
17Abnormality of the calf musculature (HP:0001430)3.50014661
18Foot dorsiflexor weakness (HP:0009027)3.45762148
19Hypothermia (HP:0002045)3.45739737
20Steppage gait (HP:0003376)3.44346246
21Camptodactyly of toe (HP:0001836)3.38962385
22Type 1 muscle fiber predominance (HP:0003803)3.38652808
23Hammertoe (HP:0001765)3.37225799
24Muscle hypertrophy of the lower extremities (HP:0008968)3.36673760
25Syncope (HP:0001279)3.36349676
26Glucose intolerance (HP:0000833)3.29754926
27Atrial fibrillation (HP:0005110)3.26027823
28Increased connective tissue (HP:0009025)3.24324962
29Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.23596524
30Distal arthrogryposis (HP:0005684)3.21569395
31Hyporeflexia of lower limbs (HP:0002600)3.10129624
32Nemaline bodies (HP:0003798)3.08132185
33Cerebral hemorrhage (HP:0001342)3.05514409
34Broad metatarsal (HP:0001783)3.04875678
35Submucous cleft hard palate (HP:0000176)3.03313279
36Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.01755897
37Abnormality of the foot musculature (HP:0001436)3.01713374
38Muscle fiber inclusion bodies (HP:0100299)3.00203419
39Onion bulb formation (HP:0003383)3.00079980
40Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.99275111
41Hyperventilation (HP:0002883)2.99250182
42Hypercortisolism (HP:0001578)2.96253831
43Primary atrial arrhythmia (HP:0001692)2.95473113
44Bradycardia (HP:0001662)2.93374471
45Myotonia (HP:0002486)2.88936967
46Tachypnea (HP:0002789)2.86311587
47Abnormality of pain sensation (HP:0010832)2.85603257
48Impaired pain sensation (HP:0007328)2.85603257
49Supraventricular tachycardia (HP:0004755)2.74390852
50Xerostomia (HP:0000217)2.72971589
51Decreased motor nerve conduction velocity (HP:0003431)2.71983966
52Supraventricular arrhythmia (HP:0005115)2.70312628
53Hypoalphalipoproteinemia (HP:0003233)2.68719606
54Bone cyst (HP:0012062)2.66951582
55Reduced subcutaneous adipose tissue (HP:0003758)2.65648242
56Distal sensory impairment (HP:0002936)2.58636588
57Abnormal glucose tolerance (HP:0001952)2.58556223
58Decreased circulating renin level (HP:0003351)2.57458258
59Abnormal pancreas size (HP:0012094)2.53579387
60Absent phalangeal crease (HP:0006109)2.53501977
61Lymphangioma (HP:0100764)2.53129421
62Overgrowth (HP:0001548)2.51606053
63Neoplasm of the peripheral nervous system (HP:0100007)2.51285615
64Heart block (HP:0012722)2.51228737
65Keratoconus (HP:0000563)2.50489820
66Increased corneal curvature (HP:0100692)2.50489820
67Ventricular tachycardia (HP:0004756)2.49891022
68Abnormality of alanine metabolism (HP:0010916)2.49552154
69Hyperalaninemia (HP:0003348)2.49552154
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49552154
71Flexion contracture of toe (HP:0005830)2.47579848
72Joint contractures involving the joints of the feet (HP:0100492)2.47579848
73Hypolipoproteinemia (HP:0010981)2.47133270
74Atonic seizures (HP:0010819)2.45402059
75Neoplasm of the heart (HP:0100544)2.42497059
76Hyperpituitarism (HP:0010514)2.37041768
77Left ventricular hypertrophy (HP:0001712)2.35375775
78Impaired proprioception (HP:0010831)2.33547828
79Abnormal hemoglobin (HP:0011902)2.33291305
80Thoracolumbar scoliosis (HP:0002944)2.32423369
81Prominent supraorbital ridges (HP:0000336)2.32413812
82Febrile seizures (HP:0002373)2.31331427
83Respiratory distress (HP:0002098)2.28812327
84Abnormality of the renal cortex (HP:0011035)2.28635268
85Lower limb muscle weakness (HP:0007340)2.28430516
86Cutaneous finger syndactyly (HP:0010554)2.27973451
87Prolonged QT interval (HP:0001657)2.27863541
88Spinal rigidity (HP:0003306)2.24087610
89Retinal atrophy (HP:0001105)2.22833784
90Aqueductal stenosis (HP:0002410)2.21815137
91Abnormal finger flexion creases (HP:0006143)2.21686345
92Limited hip movement (HP:0008800)2.21183402
93Potter facies (HP:0002009)2.20258287
94Facial shape deformation (HP:0011334)2.20258287
95Abnormal atrioventricular conduction (HP:0005150)2.18502871
96Pancreatic cysts (HP:0001737)2.18253162
97Large hands (HP:0001176)2.18138789
98Abnormality of the ischium (HP:0003174)2.17852750
99Pigmentary retinal degeneration (HP:0001146)2.15862619
100Abnormality of the vocal cords (HP:0008777)2.13733509
101Ventricular arrhythmia (HP:0004308)2.13611980
102Cerebral aneurysm (HP:0004944)2.13295939
103Pancreatic fibrosis (HP:0100732)2.12866783
104Hypertriglyceridemia (HP:0002155)2.12208146
105Difficulty running (HP:0009046)2.11724170
106Tubulointerstitial fibrosis (HP:0005576)2.10831801
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10806099
108Round ear (HP:0100830)2.09420170
109Striae distensae (HP:0001065)2.09386964
110Fragile skin (HP:0001030)2.08519712
111Concave nail (HP:0001598)2.07729811
112Lipoatrophy (HP:0100578)2.07142339
113Genital tract atresia (HP:0001827)2.07025033
114Increased CSF protein (HP:0002922)2.04312536
115Rectal prolapse (HP:0002035)2.03829634
116Vaginal atresia (HP:0000148)2.03559894
117Epidermoid cyst (HP:0200040)2.03481198
118Congenital stationary night blindness (HP:0007642)2.02532645
119Increased variability in muscle fiber diameter (HP:0003557)2.02021235
120Orthostatic hypotension (HP:0001278)2.01308155
121Chin dimple (HP:0010751)2.00815713
122Cutaneous syndactyly (HP:0012725)1.99726565
123Focal seizures (HP:0007359)1.99343183
124Aortic aneurysm (HP:0004942)1.99062557
125Intestinal atresia (HP:0011100)1.97687567
126Aplasia of the musculature (HP:0100854)1.97666039
127Abnormal autonomic nervous system physiology (HP:0012332)1.97115346
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.96910815
129Decreased muscle mass (HP:0003199)1.96865694
130Nephronophthisis (HP:0000090)1.96856718
131Muscle fiber splitting (HP:0003555)1.95889761
132Dilated cardiomyopathy (HP:0001644)1.92769572
133Palpitations (HP:0001962)1.92393574
134Difficulty climbing stairs (HP:0003551)1.92011589
135Renal cortical cysts (HP:0000803)1.91991459
136Ankle contracture (HP:0006466)1.90811573
137Atrophic scars (HP:0001075)1.90645339
138Molar tooth sign on MRI (HP:0002419)1.90432245
139Abnormality of midbrain morphology (HP:0002418)1.90432245
140Facial diplegia (HP:0001349)1.90314325
141Postural tremor (HP:0002174)1.90157840
142True hermaphroditism (HP:0010459)1.90003663
143Metaphyseal dysplasia (HP:0100255)1.88785767
144Hip contracture (HP:0003273)1.88271640
145Focal motor seizures (HP:0011153)1.88036359
146Long toe (HP:0010511)1.87272905
147Medial flaring of the eyebrow (HP:0010747)1.86917542
148Hematochezia (HP:0002573)1.85668934
149Amyloidosis (HP:0011034)1.84439033
150Abnormality of the renal medulla (HP:0100957)1.84016699
151Lumbar hyperlordosis (HP:0002938)1.83418995
152Thyroid-stimulating hormone excess (HP:0002925)1.83285358
153Premature rupture of membranes (HP:0001788)1.83195268
154Aortic dissection (HP:0002647)1.82970917
155Abnormal EKG (HP:0003115)1.82912199
156Distal lower limb muscle weakness (HP:0009053)1.80890689
157Intrahepatic cholestasis (HP:0001406)1.80566685
158Ulnar deviation of the wrist (HP:0003049)1.80525621
159Anterior segment dysgenesis (HP:0007700)1.79438290
160EMG: myopathic abnormalities (HP:0003458)1.79084568
161Abnormality of the parathyroid morphology (HP:0011766)1.78432382
162Wrist flexion contracture (HP:0001239)1.77572208
163Symphalangism affecting the phalanges of the hand (HP:0009773)1.77431212
164Hypobetalipoproteinemia (HP:0003563)1.77089943
165Asymmetric septal hypertrophy (HP:0001670)1.77020062
166Upper limb muscle weakness (HP:0003484)1.76946844
167Areflexia of lower limbs (HP:0002522)1.76168641
168Fasciculations (HP:0002380)1.75954068
169Preaxial foot polydactyly (HP:0001841)1.75942781
170Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75526559
171Muscle stiffness (HP:0003552)1.73744581
172Follicular hyperkeratosis (HP:0007502)1.73065434
173Failure to thrive in infancy (HP:0001531)1.72923079
174Hypoventilation (HP:0002791)1.72767680
175Right ventricular cardiomyopathy (HP:0011663)1.72602162
176Dysautonomia (HP:0002459)1.72533943
177Exercise-induced muscle cramps (HP:0003710)1.71146326
178Neonatal respiratory distress (HP:0002643)1.70753933
179Knee flexion contracture (HP:0006380)1.70543743
180Abnormality of the renal collecting system (HP:0004742)1.70452158
181Interstitial pulmonary disease (HP:0006530)1.70097087
182Short tibia (HP:0005736)1.69396371
183Shawl scrotum (HP:0000049)1.69195165
184Abnormality of proline metabolism (HP:0010907)1.68665963
185Hydroxyprolinuria (HP:0003080)1.68665963
186Atrioventricular block (HP:0001678)1.68355268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.35010950
2NEK93.82858903
3SIK33.79399412
4TIE12.80688747
5MINK12.68454357
6GRK12.48545256
7NTRK32.38698076
8MAPKAPK32.33145308
9CASK2.24746925
10PIK3CG2.01297504
11FER1.93942461
12BCR1.91494580
13NTRK11.89534546
14EPHB11.89037042
15CAMK1D1.80567963
16PHKG11.78708496
17PHKG21.78708496
18EPHA31.78552058
19DMPK1.76699417
20TNIK1.73174392
21TAOK31.71581109
22MAP3K21.68649500
23FGFR31.66462031
24ADRBK21.65383532
25LATS21.64045111
26RET1.60325191
27PAK31.57551322
28LIMK11.55797778
29ACVR1B1.47054635
30SGK21.46140311
31LATS11.44994200
32KSR21.42412585
33MAP2K11.41352732
34MAP2K41.40160123
35EPHB21.37468780
36CCNB11.37218585
37MYLK1.35552407
38MAP3K41.35084022
39MUSK1.32854633
40SGK2231.28949516
41SGK4941.28949516
42MST41.28931024
43WNK11.28633405
44WNK31.26634544
45GRK51.25964195
46MAP3K121.25307521
47AKT31.24447470
48MARK11.23868062
49CAMK1G1.23512875
50FRK1.22387608
51RPS6KA21.22218334
52PDK41.17574950
53PDK31.17574950
54NLK1.17352196
55TGFBR21.12576811
56TRIB31.12078762
57PTK2B1.11448359
58MAPK151.11216100
59OXSR11.11134076
60FGFR41.09074224
61SGK31.07014113
62SIK11.04958823
63MAP3K91.02457557
64NUAK10.94522883
65PRKD30.94308099
66MAP2K70.94077852
67PRKCH0.93104237
68FGFR20.90341765
69CAMKK20.85764934
70GRK70.85377051
71MAP4K20.84054886
72PBK0.81713951
73MST1R0.81700184
74MATK0.81661113
75TRPM70.78243523
76TXK0.78154613
77BCKDK0.77994642
78CDK190.77851824
79STK390.77430679
80CAMK2A0.75470469
81PRKAA20.74570607
82STK240.72850750
83PIK3CA0.72715958
84ZAK0.72213676
85TGFBR10.72158223
86PRKG10.71958801
87RIPK10.70870838
88PDGFRA0.66845917
89TTN0.65377568
90PRKD10.64720012
91PRKACB0.63113098
92PRKG20.62660444
93PRKACA0.62326623
94STK30.61671663
95MAPK70.60953070
96CAMK2D0.60612628
97ROCK10.59121082
98ADRBK10.58181207
99PDGFRB0.57137151
100SCYL20.56470179
101JAK10.56414536
102ERBB40.56248423
103PDK20.54256496
104KIT0.54011207
105KSR10.52375349
106MAPK110.52137893
107MAP2K20.52030856
108MAPK120.51659962
109MKNK20.51462211
110PTK20.51448632
111PKN10.50443995
112PINK10.50417024
113MAP3K30.49844133
114CDK50.49742826
115PRKCE0.49415197
116BMPR1B0.48823096
117PNCK0.48714928
118CAMK2G0.48279949
119WNK40.47901586
120CAMK10.47192856
121PRKCG0.47048271
122ERBB20.45760152
123MAPK130.45099292
124PRKAA10.44929936
125PDPK10.43484834
126PRKACG0.43050163
127MARK30.42531116
128SRC0.42095169
129GSK3A0.41565013
130NTRK20.41091854
131ROCK20.41026068
132IGF1R0.40912364
133MAP3K10.40873358
134RPS6KA60.40770060
135STK40.39808203
136CSNK1G10.39047039
137STK38L0.37650119
138PRKCA0.37180661
139TNK20.35385113
140DAPK20.34763084
141PLK20.34749292
142MARK20.34613549
143YES10.34262808
144PAK60.33751112
145STK110.33590891
146MAP3K140.33411058
147INSRR0.32906712
148MAP3K70.32738121
149CAMK40.32557566
150PAK20.32400211
151OBSCN0.32287249
152DDR20.32221121
153CSNK1D0.31467286
154MAPK40.31274741

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.46224998
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36053905
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.25368397
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23597612
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.23091620
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.20386117
7Butanoate metabolism_Homo sapiens_hsa006502.17646544
8Fatty acid biosynthesis_Homo sapiens_hsa000612.17137791
9Linoleic acid metabolism_Homo sapiens_hsa005912.16542078
10Propanoate metabolism_Homo sapiens_hsa006402.07307256
11Taste transduction_Homo sapiens_hsa047421.97501949
12PPAR signaling pathway_Homo sapiens_hsa033201.96597639
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90263583
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83996086
15Tryptophan metabolism_Homo sapiens_hsa003801.76768580
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.75588677
17Nitrogen metabolism_Homo sapiens_hsa009101.75231167
18Vitamin digestion and absorption_Homo sapiens_hsa049771.72842509
19Phototransduction_Homo sapiens_hsa047441.66844289
20ABC transporters_Homo sapiens_hsa020101.53885402
21Complement and coagulation cascades_Homo sapiens_hsa046101.53198821
22Fatty acid metabolism_Homo sapiens_hsa012121.52797725
23Ether lipid metabolism_Homo sapiens_hsa005651.46932938
24ECM-receptor interaction_Homo sapiens_hsa045121.45389304
25Pyruvate metabolism_Homo sapiens_hsa006201.39312962
26Insulin signaling pathway_Homo sapiens_hsa049101.38574735
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37915527
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.37747737
29Synaptic vesicle cycle_Homo sapiens_hsa047211.32659758
30Peroxisome_Homo sapiens_hsa041461.30750793
31Chemical carcinogenesis_Homo sapiens_hsa052041.29236640
32Renin secretion_Homo sapiens_hsa049241.27830843
33Glycerolipid metabolism_Homo sapiens_hsa005611.24549539
34Olfactory transduction_Homo sapiens_hsa047401.23601105
35Dorso-ventral axis formation_Homo sapiens_hsa043201.22173386
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20520539
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19319542
38Focal adhesion_Homo sapiens_hsa045101.16585975
39Melanoma_Homo sapiens_hsa052181.14379452
40Dilated cardiomyopathy_Homo sapiens_hsa054141.11720832
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11417761
42Fatty acid degradation_Homo sapiens_hsa000711.10388201
43Insulin resistance_Homo sapiens_hsa049311.09862058
44Caffeine metabolism_Homo sapiens_hsa002321.09304561
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.08634630
46Circadian rhythm_Homo sapiens_hsa047101.08071155
47Selenocompound metabolism_Homo sapiens_hsa004501.07323947
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07228680
49Ovarian steroidogenesis_Homo sapiens_hsa049131.05410579
50Salivary secretion_Homo sapiens_hsa049701.05252708
51Histidine metabolism_Homo sapiens_hsa003401.05221169
52Tight junction_Homo sapiens_hsa045301.04114652
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03985554
54Viral myocarditis_Homo sapiens_hsa054161.03892991
55Protein digestion and absorption_Homo sapiens_hsa049741.03778066
56beta-Alanine metabolism_Homo sapiens_hsa004101.00163985
57Thyroid cancer_Homo sapiens_hsa052160.99735130
58* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99259492
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97667041
60Mineral absorption_Homo sapiens_hsa049780.95999416
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95642492
62Oxidative phosphorylation_Homo sapiens_hsa001900.95435473
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.95199647
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95176152
65Arachidonic acid metabolism_Homo sapiens_hsa005900.94391719
66Fatty acid elongation_Homo sapiens_hsa000620.94120555
67Retinol metabolism_Homo sapiens_hsa008300.93641132
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93612908
69Insulin secretion_Homo sapiens_hsa049110.91859896
70Cholinergic synapse_Homo sapiens_hsa047250.89597362
71AMPK signaling pathway_Homo sapiens_hsa041520.88556445
72Type II diabetes mellitus_Homo sapiens_hsa049300.88144022
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87097601
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87009217
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85587415
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.85051684
77Arginine and proline metabolism_Homo sapiens_hsa003300.84780300
78cAMP signaling pathway_Homo sapiens_hsa040240.84447240
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.83410054
80Bile secretion_Homo sapiens_hsa049760.83324410
81Thyroid hormone synthesis_Homo sapiens_hsa049180.83321729
82Glucagon signaling pathway_Homo sapiens_hsa049220.81992249
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.80901324
84Dopaminergic synapse_Homo sapiens_hsa047280.79242710
85Endocytosis_Homo sapiens_hsa041440.78455078
86Cardiac muscle contraction_Homo sapiens_hsa042600.78395159
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77069042
88Rap1 signaling pathway_Homo sapiens_hsa040150.76957474
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75810855
90Phagosome_Homo sapiens_hsa041450.75232184
91Gastric acid secretion_Homo sapiens_hsa049710.74794154
92Circadian entrainment_Homo sapiens_hsa047130.74264266
93Endometrial cancer_Homo sapiens_hsa052130.73951993
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73197894
95Glioma_Homo sapiens_hsa052140.72944697
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72838982
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72452089
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72259700
99Gap junction_Homo sapiens_hsa045400.72049259
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71897330
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71075065
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69543824
103Axon guidance_Homo sapiens_hsa043600.68217144
104Amoebiasis_Homo sapiens_hsa051460.67891821
105Melanogenesis_Homo sapiens_hsa049160.67158401
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66977226
107GnRH signaling pathway_Homo sapiens_hsa049120.66918307
108Pancreatic secretion_Homo sapiens_hsa049720.64887164
109Salmonella infection_Homo sapiens_hsa051320.63663090
110Ras signaling pathway_Homo sapiens_hsa040140.62766976
111Calcium signaling pathway_Homo sapiens_hsa040200.62748487
112ErbB signaling pathway_Homo sapiens_hsa040120.61358317
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59630932
114Morphine addiction_Homo sapiens_hsa050320.59461371
115Sulfur metabolism_Homo sapiens_hsa009200.59414697
116Proteoglycans in cancer_Homo sapiens_hsa052050.59085347
117Sphingolipid metabolism_Homo sapiens_hsa006000.59015710
118Hedgehog signaling pathway_Homo sapiens_hsa043400.58260281
119Serotonergic synapse_Homo sapiens_hsa047260.58010182
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56745447
121TGF-beta signaling pathway_Homo sapiens_hsa043500.56745296
122Prolactin signaling pathway_Homo sapiens_hsa049170.55744669
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55552072
124Glutathione metabolism_Homo sapiens_hsa004800.55383294
125Oxytocin signaling pathway_Homo sapiens_hsa049210.53514811
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.53148734
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51165781
128Long-term potentiation_Homo sapiens_hsa047200.51082871
129Estrogen signaling pathway_Homo sapiens_hsa049150.50657853
130Adherens junction_Homo sapiens_hsa045200.50302365
131Parkinsons disease_Homo sapiens_hsa050120.50154163
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49099209
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48813302
134Renin-angiotensin system_Homo sapiens_hsa046140.48705730
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48683254
136Platelet activation_Homo sapiens_hsa046110.48561431
137Prion diseases_Homo sapiens_hsa050200.48368420
138Alzheimers disease_Homo sapiens_hsa050100.47337535
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47267259
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46692883
141Tyrosine metabolism_Homo sapiens_hsa003500.46655510
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46407125
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46063271
144MAPK signaling pathway_Homo sapiens_hsa040100.45851983
145Fat digestion and absorption_Homo sapiens_hsa049750.45128502
146Basal cell carcinoma_Homo sapiens_hsa052170.44996901
147Toxoplasmosis_Homo sapiens_hsa051450.44836454
148Glutamatergic synapse_Homo sapiens_hsa047240.42193605
149Arginine biosynthesis_Homo sapiens_hsa002200.41587938
150Cocaine addiction_Homo sapiens_hsa050300.41069730
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40332625
152Amphetamine addiction_Homo sapiens_hsa050310.39620158
153Hippo signaling pathway_Homo sapiens_hsa043900.39104661
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38585007
155Nicotine addiction_Homo sapiens_hsa050330.34350930

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