SCN9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)5.49661003
2neurofilament cytoskeleton organization (GO:0060052)5.20390083
3pyrimidine nucleobase catabolic process (GO:0006208)4.80348540
4negative regulation of dendrite morphogenesis (GO:0050774)4.67103680
5neuron cell-cell adhesion (GO:0007158)4.50647795
6negative regulation of microtubule polymerization (GO:0031115)4.48647363
7cell migration in hindbrain (GO:0021535)4.35168883
8calcium-mediated signaling using intracellular calcium source (GO:0035584)4.33022805
9detection of temperature stimulus (GO:0016048)4.28923892
10sensory perception of chemical stimulus (GO:0007606)4.27005532
11detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.20040549
12detection of temperature stimulus involved in sensory perception (GO:0050961)4.20040549
13* neuronal action potential (GO:0019228)4.12045881
14phenol-containing compound catabolic process (GO:0019336)4.03509987
15neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.91645011
16sympathetic nervous system development (GO:0048485)3.90307664
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86875591
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.83721842
19adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.80319141
20negative regulation of calcium ion transport into cytosol (GO:0010523)3.79820176
21nucleobase catabolic process (GO:0046113)3.79667236
22protein localization to cilium (GO:0061512)3.74918617
23detection of calcium ion (GO:0005513)3.74033768
24peptidyl-glutamic acid carboxylation (GO:0017187)3.73341813
25protein carboxylation (GO:0018214)3.73341813
26peripheral nervous system neuron development (GO:0048935)3.69395918
27proline transport (GO:0015824)3.64081964
28negative regulation of axon guidance (GO:1902668)3.63896514
29mating behavior (GO:0007617)3.57666499
30behavioral response to nicotine (GO:0035095)3.57619830
31negative regulation of fibrinolysis (GO:0051918)3.53557761
32regulation of synaptic vesicle exocytosis (GO:2000300)3.45070457
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44911712
34* membrane depolarization during action potential (GO:0086010)3.43452878
35neurotransmitter-gated ion channel clustering (GO:0072578)3.42374408
36neuromuscular synaptic transmission (GO:0007274)3.40471969
37protein polyglutamylation (GO:0018095)3.39033672
38regulation of fibrinolysis (GO:0051917)3.36662750
39regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36449293
40synaptic vesicle exocytosis (GO:0016079)3.35018539
41neuronal action potential propagation (GO:0019227)3.32262923
42* response to pain (GO:0048265)3.26678075
43behavioral response to ethanol (GO:0048149)3.25645978
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23126683
45negative regulation of dendrite development (GO:2000171)3.22515533
46cerebellar Purkinje cell differentiation (GO:0021702)3.20758506
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17953385
48negative regulation of axon extension involved in axon guidance (GO:0048843)3.17456325
49glutamate secretion (GO:0014047)3.16712679
50regulation of axon guidance (GO:1902667)3.16008479
51cellular response to nicotine (GO:0071316)3.13185932
52retinal ganglion cell axon guidance (GO:0031290)3.11527881
53synaptic vesicle maturation (GO:0016188)3.11469330
54sensory perception of taste (GO:0050909)3.05768113
55establishment of mitochondrion localization (GO:0051654)3.05304517
56mitochondrion transport along microtubule (GO:0047497)3.04521973
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04521973
58positive regulation of potassium ion transmembrane transport (GO:1901381)3.04201595
59regulation of protein kinase A signaling (GO:0010738)3.02408323
60innervation (GO:0060384)3.01893479
61gamma-aminobutyric acid transport (GO:0015812)3.01552096
62axon extension involved in axon guidance (GO:0048846)3.01278431
63neuron projection extension involved in neuron projection guidance (GO:1902284)3.01278431
64axonal fasciculation (GO:0007413)3.00092661
65urinary tract smooth muscle contraction (GO:0014848)2.99947377
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99933681
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99462288
68sequestering of actin monomers (GO:0042989)2.98235068
69peptidyl-glutamic acid modification (GO:0018200)2.97654381
70endocardial cushion development (GO:0003197)2.97487609
71regulation of synaptic vesicle transport (GO:1902803)2.96185001
72calcium ion-dependent exocytosis (GO:0017156)2.94924905
73renal tubule morphogenesis (GO:0061333)2.94409446
74intestinal cholesterol absorption (GO:0030299)2.93563688
75activation of protein kinase A activity (GO:0034199)2.93407392
76regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.92600811
77ER overload response (GO:0006983)2.91523528
78response to water (GO:0009415)2.89920614
79nephron epithelium morphogenesis (GO:0072088)2.89325876
80nephron tubule morphogenesis (GO:0072078)2.89325876
81cellular response to glucagon stimulus (GO:0071377)2.88228972
82* action potential (GO:0001508)2.87550788
83axon extension (GO:0048675)2.87516852
84negative regulation of cation channel activity (GO:2001258)2.87383870
85positive regulation of male gonad development (GO:2000020)2.85969803
86catecholamine biosynthetic process (GO:0042423)2.85577449
87catechol-containing compound biosynthetic process (GO:0009713)2.85577449
88axoneme assembly (GO:0035082)2.85072352
89positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.84525095
90cellular response to prostaglandin stimulus (GO:0071379)2.83933627
91maternal behavior (GO:0042711)2.83419221
92tachykinin receptor signaling pathway (GO:0007217)2.83291498
93organelle transport along microtubule (GO:0072384)2.82932881
94positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82455545
95neuron fate specification (GO:0048665)2.82203228
96regulation of axon extension involved in axon guidance (GO:0048841)2.81759294
97positive regulation of action potential (GO:0045760)2.81509285
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79790581
99neuron recognition (GO:0008038)2.79061527
100regulation of plasminogen activation (GO:0010755)2.79013447
101protein localization to synapse (GO:0035418)2.78843048
102neurotransmitter secretion (GO:0007269)2.78732901
103chondrocyte proliferation (GO:0035988)2.76944480
104cell communication involved in cardiac conduction (GO:0086065)2.76628321
105positive regulation of synapse assembly (GO:0051965)2.76588721
106regulation of cell communication by electrical coupling (GO:0010649)2.75684532
107cilium morphogenesis (GO:0060271)2.74709795
108dopamine receptor signaling pathway (GO:0007212)2.74653187
109synapse assembly (GO:0007416)2.73963796
110neuromuscular process controlling posture (GO:0050884)2.73856597
111axon cargo transport (GO:0008088)2.72285660
112dopamine biosynthetic process (GO:0042416)2.72239066
113catecholamine transport (GO:0051937)2.71060667
114kidney mesenchyme development (GO:0072074)2.71044684
115positive regulation of amino acid transport (GO:0051957)2.70580320
116microtubule-based transport (GO:0010970)2.70251651
117detection of mechanical stimulus involved in sensory perception (GO:0050974)2.69116543
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.67358088
119negative regulation of homotypic cell-cell adhesion (GO:0034111)2.66930139
120negative chemotaxis (GO:0050919)2.66906872
121regulation of cAMP-dependent protein kinase activity (GO:2000479)2.66862671
122regulation of neurotransmitter secretion (GO:0046928)2.64688499
123positive regulation of potassium ion transport (GO:0043268)2.64559368
124brain morphogenesis (GO:0048854)2.63542330
125inositol phosphate catabolic process (GO:0071545)2.62877514
126vesicle transport along microtubule (GO:0047496)2.62849285
127hindbrain development (GO:0030902)2.62609634
128regulation of male gonad development (GO:2000018)2.62335763
129regulation of vesicle fusion (GO:0031338)2.61527658
130melanosome transport (GO:0032402)2.61049461
131multi-organism reproductive behavior (GO:0044705)2.60067489
132neurotransmitter catabolic process (GO:0042135)2.58689074
133regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.58006555
134collagen fibril organization (GO:0030199)2.57565832
135response to pheromone (GO:0019236)2.57191101
136cytoskeleton-dependent intracellular transport (GO:0030705)2.56236702
137indolalkylamine metabolic process (GO:0006586)2.55972877
138neurotransmitter transport (GO:0006836)2.55632406
139regulation of amyloid precursor protein catabolic process (GO:1902991)2.55162799
140regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53460788
141regulation of action potential (GO:0098900)2.49920145
142regulation of dopamine secretion (GO:0014059)2.48091370
143sequestering of extracellular ligand from receptor (GO:0035581)2.47753057
144negative regulation of mast cell activation (GO:0033004)2.47356490
145cell adhesion mediated by integrin (GO:0033627)2.45378871
146presynaptic membrane assembly (GO:0097105)2.43382347
147cranial nerve morphogenesis (GO:0021602)2.42226481
148negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41788074
149inner ear receptor cell development (GO:0060119)2.38550689
150regulation of synapse assembly (GO:0051963)2.37533428
151postsynaptic membrane organization (GO:0001941)2.36889243
152smooth muscle contraction (GO:0006939)2.36390167
153ganglion development (GO:0061548)2.35904011
154peristalsis (GO:0030432)2.35604206
155negative regulation of axon extension (GO:0030517)2.35043779
156tryptophan catabolic process (GO:0006569)2.34967797
157indole-containing compound catabolic process (GO:0042436)2.34967797
158indolalkylamine catabolic process (GO:0046218)2.34967797
159negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.34883562
160tryptophan metabolic process (GO:0006568)2.34549452
161central nervous system projection neuron axonogenesis (GO:0021952)2.34109197
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32549336
163substrate-dependent cell migration (GO:0006929)2.31360358
164regulation of protein activation cascade (GO:2000257)2.30930030
165negative regulation of chemotaxis (GO:0050922)2.28010544
166dendrite morphogenesis (GO:0048813)2.26264236
167dopamine transport (GO:0015872)2.25290507
168epithelial cell differentiation involved in kidney development (GO:0035850)2.24781344
169negative regulation of protein activation cascade (GO:2000258)2.23766089
170metanephric mesenchyme development (GO:0072075)2.22960401
171phospholipid translocation (GO:0045332)2.22659479
172lipid translocation (GO:0034204)2.22659479
173regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.22248470
174positive regulation of axon extension (GO:0045773)2.22137199
175regulation of feeding behavior (GO:0060259)2.21082006
176regulation of axon extension (GO:0030516)2.20931657
177regulation of complement activation (GO:0030449)2.20889195
178auditory behavior (GO:0031223)2.20383012
179response to auditory stimulus (GO:0010996)2.20273920
180neuron projection extension (GO:1990138)2.20035621
181microtubule severing (GO:0051013)2.19627754
182cerebral cortex cell migration (GO:0021795)2.19237698
183very-low-density lipoprotein particle assembly (GO:0034379)2.16666321
184ribonucleoprotein complex disassembly (GO:0032988)2.15634474
185positive regulation of cardiac muscle cell differentiation (GO:2000727)2.14500491
186negative regulation of activin receptor signaling pathway (GO:0032926)2.14251320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.82803790
2GBX2_23144817_ChIP-Seq_PC3_Human3.39447013
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24812810
4TAF15_26573619_Chip-Seq_HEK293_Human2.98930093
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93122570
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.67351692
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62288748
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45710467
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43082121
10REST_21632747_ChIP-Seq_MESCs_Mouse2.36747535
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35838061
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26224025
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26224025
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19077214
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.18196133
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15534635
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12499045
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12447834
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.07209550
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04285380
21FUS_26573619_Chip-Seq_HEK293_Human2.04058471
22IGF1R_20145208_ChIP-Seq_DFB_Human2.03368735
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02989244
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00672903
25NR3C1_23031785_ChIP-Seq_PC12_Mouse1.97476367
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96714991
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.94589925
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86379602
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85880905
30TP53_16413492_ChIP-PET_HCT116_Human1.85500751
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.84583295
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.82105320
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80638828
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.77669673
35VDR_22108803_ChIP-Seq_LS180_Human1.77517690
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.77515045
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76707599
38P300_19829295_ChIP-Seq_ESCs_Human1.75412857
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.73002655
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69386699
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.68765228
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66667502
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66315995
44TP53_18474530_ChIP-ChIP_U2OS_Human1.63079585
45EWS_26573619_Chip-Seq_HEK293_Human1.61283799
46DROSHA_22980978_ChIP-Seq_HELA_Human1.57258754
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57062354
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57062354
49RNF2_27304074_Chip-Seq_NSC_Mouse1.54941685
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52097179
51AHR_22903824_ChIP-Seq_MCF-7_Human1.47377668
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46043400
53* CJUN_26792858_Chip-Seq_BT549_Human1.45245791
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45159075
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44879331
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41968571
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.41476637
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40971397
59ZNF274_21170338_ChIP-Seq_K562_Hela1.36898107
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36473230
61* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33992444
62* CBP_20019798_ChIP-Seq_JUKART_Human1.33992444
63STAT3_23295773_ChIP-Seq_U87_Human1.32102462
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31949335
65ER_23166858_ChIP-Seq_MCF-7_Human1.31421998
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29197854
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.27225210
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.26366520
69AR_25329375_ChIP-Seq_VCAP_Human1.25168298
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24393636
71RUNX2_22187159_ChIP-Seq_PCA_Human1.22383305
72BRD4_25478319_ChIP-Seq_HGPS_Human1.22104263
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21819377
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.21635998
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21223983
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.20832549
77* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20434656
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19975030
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19784682
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19514965
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.18100492
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17359533
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.17291451
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15574916
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15146153
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.14905182
87BCAT_22108803_ChIP-Seq_LS180_Human1.14772396
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14271805
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14258421
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12671387
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.12301934
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11714239
93* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11525531
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10912836
95TRIM28_21343339_ChIP-Seq_HEK293_Human1.10199498
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10181814
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09820955
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.09792062
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09648101
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08154861
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08154861
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.07458244
103TCF4_23295773_ChIP-Seq_U87_Human1.07401084
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.06986759
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06932314
106JUN_21703547_ChIP-Seq_K562_Human1.06861973
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.06315517
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06201939
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05889741
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05814410
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05669248
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04967053
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04026965
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03460313
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.02399546
116SMAD3_21741376_ChIP-Seq_ESCs_Human1.00410350
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99682567
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.97098528
119KDM2B_26808549_Chip-Seq_REH_Human0.95320208
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93861587
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92137147
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.91878639
123AR_19668381_ChIP-Seq_PC3_Human0.91548383
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91530226
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91428898
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91425610
127* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90310534
128* NANOG_18555785_Chip-Seq_ESCs_Mouse0.88264037
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88229147
130AR_21572438_ChIP-Seq_LNCaP_Human0.87912375
131SOX2_19829295_ChIP-Seq_ESCs_Human0.87484592
132NANOG_19829295_ChIP-Seq_ESCs_Human0.87484592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception4.75192837
2MP0006276_abnormal_autonomic_nervous4.61662182
3MP0001984_abnormal_olfaction4.08131002
4MP0001968_abnormal_touch/_nociception4.03496020
5MP0004270_analgesia4.01974471
6MP0002734_abnormal_mechanical_nocicepti3.56514936
7MP0002736_abnormal_nociception_after3.44254407
8MP0008438_abnormal_cutaneous_collagen3.18622440
9MP0002733_abnormal_thermal_nociception3.12640593
10MP0004858_abnormal_nervous_system3.10962840
11MP0001986_abnormal_taste_sensitivity3.04923052
12MP0005645_abnormal_hypothalamus_physiol3.02318901
13MP0003195_calcinosis2.92062234
14MP0001970_abnormal_pain_threshold2.78732704
15MP0002822_catalepsy2.70853886
16MP0010386_abnormal_urinary_bladder2.58333187
17MP0002184_abnormal_innervation2.54882449
18MP0005503_abnormal_tendon_morphology2.22408818
19MP0002272_abnormal_nervous_system2.21416560
20MP0002751_abnormal_autonomic_nervous2.19763121
21MP0004272_abnormal_basement_membrane2.17255502
22MP0006054_spinal_hemorrhage2.17255483
23MP0005084_abnormal_gallbladder_morpholo2.10917448
24* MP0003635_abnormal_synaptic_transmissio2.10761886
25MP0005085_abnormal_gallbladder_physiolo2.08983934
26MP0008789_abnormal_olfactory_epithelium2.04276193
27MP0004859_abnormal_synaptic_plasticity2.02570382
28MP0003880_abnormal_central_pattern2.00600965
29MP0005360_urolithiasis2.00234110
30MP0000372_irregular_coat_pigmentation1.96263892
31MP0005499_abnormal_olfactory_system1.94715088
32MP0005394_taste/olfaction_phenotype1.94715088
33MP0002638_abnormal_pupillary_reflex1.94697437
34MP0002067_abnormal_sensory_capabilities1.89971270
35MP0009745_abnormal_behavioral_response1.86852882
36MP0010368_abnormal_lymphatic_system1.86235166
37MP0003950_abnormal_plasma_membrane1.83357490
38MP0003252_abnormal_bile_duct1.80884755
39MP0002572_abnormal_emotion/affect_behav1.80434259
40MP0002063_abnormal_learning/memory/cond1.78047312
41MP0005365_abnormal_bile_salt1.74779529
42MP0005423_abnormal_somatic_nervous1.74590401
43MP0002102_abnormal_ear_morphology1.68794159
44MP0001905_abnormal_dopamine_level1.66035122
45MP0009046_muscle_twitch1.65310543
46* MP0002064_seizures1.61162275
47MP0003122_maternal_imprinting1.60708771
48MP0000778_abnormal_nervous_system1.60682260
49MP0001440_abnormal_grooming_behavior1.60182230
50MP0002909_abnormal_adrenal_gland1.59622123
51MP0005646_abnormal_pituitary_gland1.57732608
52MP0009384_cardiac_valve_regurgitation1.55422445
53MP0001501_abnormal_sleep_pattern1.53816711
54MP0003183_abnormal_peptide_metabolism1.53388990
55MP0003868_abnormal_feces_composition1.52961710
56MP0000538_abnormal_urinary_bladder1.52076031
57MP0002139_abnormal_hepatobiliary_system1.51933370
58MP0002557_abnormal_social/conspecific_i1.50790193
59MP0001529_abnormal_vocalization1.43198129
60MP0000955_abnormal_spinal_cord1.42980846
61MP0004811_abnormal_neuron_physiology1.41791806
62MP0001188_hyperpigmentation1.41386931
63MP0002882_abnormal_neuron_morphology1.35356806
64MP0005386_behavior/neurological_phenoty1.29722726
65MP0004924_abnormal_behavior1.29722726
66MP0003942_abnormal_urinary_system1.27117934
67MP0002837_dystrophic_cardiac_calcinosis1.25347135
68MP0005379_endocrine/exocrine_gland_phen1.24552649
69MP0005187_abnormal_penis_morphology1.23709649
70MP0001486_abnormal_startle_reflex1.22481094
71MP0003787_abnormal_imprinting1.21536176
72MP0005623_abnormal_meninges_morphology1.18668755
73MP0002160_abnormal_reproductive_system1.18179047
74MP0005257_abnormal_intraocular_pressure1.15986981
75MP0002163_abnormal_gland_morphology1.15982409
76MP0002752_abnormal_somatic_nervous1.15465190
77MP0008875_abnormal_xenobiotic_pharmacok1.14238839
78MP0010329_abnormal_lipoprotein_level1.13794699
79MP0004133_heterotaxia1.13625443
80MP0009697_abnormal_copulation1.13202084
81MP0001666_abnormal_nutrient_absorption1.12220151
82MP0002295_abnormal_pulmonary_circulatio1.09826953
83MP0001958_emphysema1.09426297
84MP0004742_abnormal_vestibular_system1.08307623
85MP0002876_abnormal_thyroid_physiology1.06644058
86MP0003279_aneurysm1.06527776
87MP0009250_abnormal_appendicular_skeleto1.05223666
88MP0004134_abnormal_chest_morphology1.03644754
89MP0001270_distended_abdomen1.03469232
90MP0005275_abnormal_skin_tensile1.02095495
91MP0002229_neurodegeneration0.97755368
92MP0002066_abnormal_motor_capabilities/c0.97447382
93MP0001502_abnormal_circadian_rhythm0.96897760
94MP0001485_abnormal_pinna_reflex0.95246144
95MP0000013_abnormal_adipose_tissue0.89557515
96MP0002234_abnormal_pharynx_morphology0.87544186
97MP0001348_abnormal_lacrimal_gland0.86911920
98MP0002938_white_spotting0.86891269
99MP0004142_abnormal_muscle_tone0.86819797
100MP0002282_abnormal_trachea_morphology0.85163951
101MP0003937_abnormal_limbs/digits/tail_de0.84687459
102MP0008569_lethality_at_weaning0.84400985
103MP0001299_abnormal_eye_distance/0.84102427
104MP0003879_abnormal_hair_cell0.83985776
105MP0001963_abnormal_hearing_physiology0.83081644
106MP0000049_abnormal_middle_ear0.82710282
107MP0000569_abnormal_digit_pigmentation0.80539308
108MP0005195_abnormal_posterior_eye0.80392519
109MP0002233_abnormal_nose_morphology0.79976903
110MP0005595_abnormal_vascular_smooth0.79487245
111MP0003633_abnormal_nervous_system0.79133062
112MP0005535_abnormal_body_temperature0.79096389
113MP0003634_abnormal_glial_cell0.77916911
114MP0000631_abnormal_neuroendocrine_gland0.77733680
115MP0003890_abnormal_embryonic-extraembry0.77095018
116MP0004085_abnormal_heartbeat0.75946336
117MP0002693_abnormal_pancreas_physiology0.75894911
118MP0002152_abnormal_brain_morphology0.73141593
119MP0009780_abnormal_chondrocyte_physiolo0.71552134
120MP0002069_abnormal_eating/drinking_beha0.69791177
121MP0005171_absent_coat_pigmentation0.68945802
122MP0008872_abnormal_physiological_respon0.68792852
123MP0003329_amyloid_beta_deposits0.66585298
124MP0004145_abnormal_muscle_electrophysio0.64259464
125MP0000751_myopathy0.63946800
126MP0006072_abnormal_retinal_apoptosis0.63619566
127MP0003631_nervous_system_phenotype0.62331269
128MP0001664_abnormal_digestion0.59651360
129MP0001944_abnormal_pancreas_morphology0.59472183
130MP0005389_reproductive_system_phenotype0.58453953
131MP0000026_abnormal_inner_ear0.56203896
132MP0008874_decreased_physiological_sensi0.54718290
133MP0003121_genomic_imprinting0.54329189
134MP0005551_abnormal_eye_electrophysiolog0.53420408
135MP0001542_abnormal_bone_strength0.53052947
136MP0003953_abnormal_hormone_level0.52826899
137MP0003283_abnormal_digestive_organ0.52476166
138MP0000534_abnormal_ureter_morphology0.49815646
139MP0001943_abnormal_respiration0.49720415
140MP0000015_abnormal_ear_pigmentation0.48305009

Predicted human phenotypes

RankGene SetZ-score
1* Hypothermia (HP:0002045)5.32212281
2Myokymia (HP:0002411)5.20591534
3Ulnar claw (HP:0001178)4.81380703
4Limb dystonia (HP:0002451)4.65331703
5Pheochromocytoma (HP:0002666)4.47541442
6Neuroendocrine neoplasm (HP:0100634)4.08628557
7Action tremor (HP:0002345)3.83051912
8Focal motor seizures (HP:0011153)3.75945354
9Termporal pattern (HP:0011008)3.70525094
10Insidious onset (HP:0003587)3.70525094
11Premature rupture of membranes (HP:0001788)3.61111386
12Protrusio acetabuli (HP:0003179)3.54298647
13Abnormal autonomic nervous system physiology (HP:0012332)3.40735639
14Deep venous thrombosis (HP:0002625)3.39200107
15Peritonitis (HP:0002586)3.35465282
16Dysautonomia (HP:0002459)3.28209203
17Failure to thrive in infancy (HP:0001531)3.26297265
18Aortic dissection (HP:0002647)3.25972379
19Visual hallucinations (HP:0002367)3.22789452
20Gait imbalance (HP:0002141)3.22140239
21Ankle clonus (HP:0011448)3.21253527
22Hyperventilation (HP:0002883)3.19896929
23Increased corneal curvature (HP:0100692)3.18048576
24Keratoconus (HP:0000563)3.18048576
25Progressive cerebellar ataxia (HP:0002073)3.17914402
26Prolonged partial thromboplastin time (HP:0003645)3.12410715
27Genital tract atresia (HP:0001827)3.10349271
28Orthostatic hypotension (HP:0001278)3.10080143
29Agitation (HP:0000713)3.09783956
30Retinal dysplasia (HP:0007973)3.04614186
31Soft skin (HP:0000977)3.03699329
32Medial flaring of the eyebrow (HP:0010747)3.01013018
33Drooling (HP:0002307)3.00373933
34Neonatal short-limb short stature (HP:0008921)3.00247073
35Abnormality of calcium-phosphate metabolism (HP:0100530)2.97813935
36Aortic aneurysm (HP:0004942)2.96222135
37Congenital primary aphakia (HP:0007707)2.94932282
38Follicular hyperkeratosis (HP:0007502)2.89734025
39* Focal seizures (HP:0007359)2.84028697
40Thyroid carcinoma (HP:0002890)2.81649197
41Nephrogenic diabetes insipidus (HP:0009806)2.81611866
42Vaginal atresia (HP:0000148)2.80606619
43Abnormality of dentin (HP:0010299)2.79852761
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.76391890
45Abnormal hair whorl (HP:0010721)2.76133659
46Amblyopia (HP:0000646)2.74555976
47Vascular tortuosity (HP:0004948)2.73765422
48Polyphagia (HP:0002591)2.67424386
49Abnormal ciliary motility (HP:0012262)2.67074099
50Cardiovascular calcification (HP:0011915)2.66619935
51* Febrile seizures (HP:0002373)2.65135599
52Exotropia (HP:0000577)2.65059237
53Abnormal respiratory motile cilium physiology (HP:0012261)2.58885705
54Excessive salivation (HP:0003781)2.58516825
55Hypoventilation (HP:0002791)2.51803148
56* Impaired pain sensation (HP:0007328)2.50270957
57* Abnormality of pain sensation (HP:0010832)2.50270957
58Foot dorsiflexor weakness (HP:0009027)2.50218814
59Pancreatic fibrosis (HP:0100732)2.49792701
60Arterial tortuosity (HP:0005116)2.45830105
61Truncal ataxia (HP:0002078)2.44909019
62Supranuclear gaze palsy (HP:0000605)2.43947765
63Hypercortisolism (HP:0001578)2.43557470
64Hypoplasia of the brainstem (HP:0002365)2.43309309
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.43309309
66Abnormality of the corticospinal tract (HP:0002492)2.41639266
67Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.41552163
68Abnormality of the wing of the ilium (HP:0011867)2.39929665
69Broad-based gait (HP:0002136)2.37845348
70Submucous cleft hard palate (HP:0000176)2.37434832
71Abnormality of midbrain morphology (HP:0002418)2.37227307
72Molar tooth sign on MRI (HP:0002419)2.37227307
73Menstrual irregularities (HP:0000858)2.35994704
74Acute necrotizing encephalopathy (HP:0006965)2.35885404
75Pachygyria (HP:0001302)2.35771638
76Myotonia (HP:0002486)2.34270232
77Lissencephaly (HP:0001339)2.33624180
78Vascular calcification (HP:0004934)2.32616913
79Autoamputation (HP:0001218)2.31902663
80Specific learning disability (HP:0001328)2.30451072
81Progressive macrocephaly (HP:0004481)2.25984963
82Conjugated hyperbilirubinemia (HP:0002908)2.20569764
83Mask-like facies (HP:0000298)2.19639375
84Abnormality of the common coagulation pathway (HP:0010990)2.19591859
85Abnormality of the foot musculature (HP:0001436)2.19146522
86Steppage gait (HP:0003376)2.17562322
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17100438
88Morphological abnormality of the middle ear (HP:0008609)2.16005692
89Bladder diverticulum (HP:0000015)2.15646582
90Poor coordination (HP:0002370)2.14797485
91Hypophosphatemic rickets (HP:0004912)2.14002098
92Abnormal respiratory epithelium morphology (HP:0012253)2.13801036
93Abnormal respiratory motile cilium morphology (HP:0005938)2.13801036
94Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.13263134
95Protruding tongue (HP:0010808)2.13214516
96Infantile muscular hypotonia (HP:0008947)2.12807647
97Postural tremor (HP:0002174)2.12744665
98Segmental peripheral demyelination/remyelination (HP:0003481)2.12227165
99Hammertoe (HP:0001765)2.10614726
100Abnormality of the vocal cords (HP:0008777)2.09716523
101Epileptic encephalopathy (HP:0200134)2.09592493
102Aplasia/Hypoplasia of the lens (HP:0008063)2.08846155
103Hydroxyprolinuria (HP:0003080)2.07513589
104Abnormality of proline metabolism (HP:0010907)2.07513589
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.07137532
106Mitral stenosis (HP:0001718)2.07079864
107Thyroid-stimulating hormone excess (HP:0002925)2.06900236
108Delayed gross motor development (HP:0002194)2.06247369
109Bifid tongue (HP:0010297)2.06221859
110Inability to walk (HP:0002540)2.06085771
111Absent speech (HP:0001344)2.04450786
112Shawl scrotum (HP:0000049)2.03548836
113Disproportionate short-trunk short stature (HP:0003521)2.02760430
114Ankle contracture (HP:0006466)2.02399785
115Anxiety (HP:0000739)2.01116236
116Prolonged QT interval (HP:0001657)2.00685363
117Abnormal mitochondria in muscle tissue (HP:0008316)1.99693298
118Hypobetalipoproteinemia (HP:0003563)1.99367195
119Spastic gait (HP:0002064)1.94545484
120Bulbous nose (HP:0000414)1.94125348
121Hyperthyroidism (HP:0000836)1.93235038
122Spontaneous abortion (HP:0005268)1.93152749
123Flared iliac wings (HP:0002869)1.92995274
124Increased number of teeth (HP:0011069)1.92452070
125* Generalized tonic-clonic seizures (HP:0002069)1.92006062
126Arthropathy (HP:0003040)1.91617757
127Distal arthrogryposis (HP:0005684)1.90971291
128Urinary bladder sphincter dysfunction (HP:0002839)1.89648994
129Syncope (HP:0001279)1.88158812
130Type II lissencephaly (HP:0007260)1.86145296
131Lower limb muscle weakness (HP:0007340)1.84427704
132Metaphyseal dysplasia (HP:0100255)1.83983841
133Broad ribs (HP:0000885)1.82663003
134Acute encephalopathy (HP:0006846)1.82387499
135Hypotension (HP:0002615)1.81668582
136Broad alveolar ridges (HP:0000187)1.81340931
137Thoracolumbar scoliosis (HP:0002944)1.81184586
138Postaxial hand polydactyly (HP:0001162)1.80091106
139Joint hemorrhage (HP:0005261)1.80087718
140Torticollis (HP:0000473)1.79558170
141Abnormality of macular pigmentation (HP:0008002)1.79036859
142Fair hair (HP:0002286)1.78513762
143Hyperparathyroidism (HP:0000843)1.78413237
144Wrist flexion contracture (HP:0001239)1.78306506
145Wide anterior fontanel (HP:0000260)1.78035223
146Adrenal overactivity (HP:0002717)1.77538912
147Potter facies (HP:0002009)1.75117506
148Facial shape deformation (HP:0011334)1.75117506
149Genetic anticipation (HP:0003743)1.74871159
150Neoplasm of the thyroid gland (HP:0100031)1.74782811
151Mitochondrial inheritance (HP:0001427)1.73987234
152Pancreatic cysts (HP:0001737)1.73961283
153Neoplasm of the peripheral nervous system (HP:0100007)1.73435191
154Rhinitis (HP:0012384)1.72918447
155EEG with generalized epileptiform discharges (HP:0011198)1.71845383
156Cutaneous finger syndactyly (HP:0010554)1.71811726
157True hermaphroditism (HP:0010459)1.71710944
158Urinary urgency (HP:0000012)1.71109398
159Prominent supraorbital ridges (HP:0000336)1.70781924
160Nephronophthisis (HP:0000090)1.69958638
161Short tibia (HP:0005736)1.68557174
162Ovoid vertebral bodies (HP:0003300)1.68503499
163Knee flexion contracture (HP:0006380)1.68377099
164Abnormal eating behavior (HP:0100738)1.67785392
165Midline defect of the nose (HP:0004122)1.67358511
166Striae distensae (HP:0001065)1.67101317
167Epileptiform EEG discharges (HP:0011182)1.66657243
168Hypsarrhythmia (HP:0002521)1.66198633
169Delayed closure of the anterior fontanelle (HP:0001476)1.65753506
170Abnormal delivery (HP:0001787)1.65368902
171Abnormality of carpal bone ossification (HP:0006257)1.62191144
172Spastic tetraplegia (HP:0002510)1.61948566
173* Abnormality of salivation (HP:0100755)1.60623918
174Long toe (HP:0010511)1.58922481
175Supernumerary spleens (HP:0009799)1.58647977
176Aortic regurgitation (HP:0001659)1.58602669
177Short foot (HP:0001773)1.57174917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.81878671
2NTRK13.69749923
3MINK12.80881004
4CASK2.59563538
5ERBB32.57948153
6MYLK2.57575713
7GRK52.50042162
8MAP4K22.39972064
9MAPK132.38759852
10ARAF2.27960200
11MAP2K72.25900049
12MARK12.25218452
13MAP3K42.14130849
14MAP3K122.13663421
15PINK12.11290088
16LIMK11.99235065
17MAP3K91.97256431
18LMTK21.92547819
19AKT31.90556418
20MAPKAPK31.89332160
21MAP3K21.86125501
22MAPK151.77317168
23DAPK21.70734120
24CAMKK21.60650614
25BMPR21.57978102
26LATS11.56964850
27SIK31.56000952
28RPS6KA21.55707011
29GRK71.52602052
30PHKG21.52094807
31PHKG11.52094807
32PIK3CG1.49030727
33GRK11.48144531
34NTRK21.47563027
35MAP2K41.46560914
36UHMK11.42770926
37PNCK1.42677599
38KSR21.38804663
39MATK1.38505793
40SGK4941.35385417
41SGK2231.35385417
42INSRR1.29179584
43DDR21.28875185
44MAPKAPK51.26039469
45SGK21.24131851
46CSNK1G31.19751830
47CSNK1G21.16790171
48RET1.12187267
49BRAF1.11296332
50ADRBK11.08164763
51PLK21.07109822
52MAP2K11.05170999
53PAK21.03248733
54PAK31.01542080
55FRK1.01485551
56PDGFRA0.96131660
57DYRK30.95830924
58WNK40.95542218
59FLT30.94956742
60TRIM280.94163187
61PRKCG0.93430803
62HIPK20.92150198
63LATS20.92043470
64BMPR1B0.91905180
65CAMK2D0.91518595
66CDK50.90388334
67STK240.89785873
68PRKCE0.88850416
69DYRK1B0.88666228
70CDK80.88623598
71TAOK30.85818654
72FER0.81541138
73CSNK1A1L0.79464306
74CAMK2B0.79327691
75ADRBK20.79166323
76MAP3K60.78507185
77WNK10.78217921
78STK390.77927817
79DYRK20.77741777
80CAMK2A0.76901916
81PRKG10.75278312
82PAK60.74864399
83WNK30.73849228
84CAMK2G0.73400628
85SIK20.73141436
86CSNK1G10.70425013
87TNIK0.67760625
88PRPF4B0.67539014
89SGK30.65571315
90TRPM70.64633846
91MAP3K50.64604201
92TNK20.64368940
93DAPK10.64233520
94PLK40.63512503
95PTK20.62686432
96EPHA30.62143991
97PKN10.61435138
98CDC42BPA0.60309758
99BCR0.55614043
100EPHB20.55058332
101MAP3K10.53602447
102SCYL20.51977293
103CLK10.51770618
104ROCK10.51736309
105CDK140.50079866
106STK380.50037102
107IRAK10.49973613
108IRAK20.49961112
109ABL20.49332597
110CAMKK10.48975578
111PRKAA10.48907980
112PRKCH0.48777763
113RPS6KB10.48159951
114PRKACA0.47505172
115PIK3CA0.46959376
116AURKA0.44970212
117NUAK10.44899257
118CDK190.44397058
119TGFBR20.43445076
120GSK3A0.43213569
121PIM20.43140155
122TIE10.43002888
123ZAK0.42626499
124ERBB20.42606595
125MAP2K20.42574131
126NME10.40057596
127PRKG20.39927996
128CSNK1D0.39109078
129PRKACG0.37441150
130CAMK1G0.37245087
131ERBB40.36220485
132PRKCZ0.36045056
133PRKCB0.34997107
134PRKACB0.34467055
135FGFR30.33893280
136YES10.33765655
137STK160.33715583
138CDK180.33343599
139DYRK1A0.33225754
140CSNK1E0.32806192
141STK38L0.32086503
142PRKD30.29220039

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.57302221
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36537452
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.18652887
4Complement and coagulation cascades_Homo sapiens_hsa046102.87851559
5Insulin secretion_Homo sapiens_hsa049112.46762706
6* Taste transduction_Homo sapiens_hsa047422.27867172
7Oxidative phosphorylation_Homo sapiens_hsa001902.25367200
8Collecting duct acid secretion_Homo sapiens_hsa049662.23953468
9Dopaminergic synapse_Homo sapiens_hsa047282.23001941
10Serotonergic synapse_Homo sapiens_hsa047262.18096776
11Butanoate metabolism_Homo sapiens_hsa006502.14084912
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09637313
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05764638
14Nicotine addiction_Homo sapiens_hsa050332.04573314
15Parkinsons disease_Homo sapiens_hsa050122.03041492
16Cholinergic synapse_Homo sapiens_hsa047252.02392560
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94398920
18Circadian entrainment_Homo sapiens_hsa047131.90070937
19Vibrio cholerae infection_Homo sapiens_hsa051101.89978723
20Amphetamine addiction_Homo sapiens_hsa050311.85181869
21GABAergic synapse_Homo sapiens_hsa047271.84422302
22Morphine addiction_Homo sapiens_hsa050321.84364705
23Phototransduction_Homo sapiens_hsa047441.83697676
24Alzheimers disease_Homo sapiens_hsa050101.66064894
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65702121
26ECM-receptor interaction_Homo sapiens_hsa045121.63174847
27Selenocompound metabolism_Homo sapiens_hsa004501.62189131
28Cocaine addiction_Homo sapiens_hsa050301.60542765
29Glutamatergic synapse_Homo sapiens_hsa047241.60454721
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.57425484
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47575730
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46163444
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43369801
34Long-term potentiation_Homo sapiens_hsa047201.40033514
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37517358
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37355031
37Salivary secretion_Homo sapiens_hsa049701.32289594
38Tryptophan metabolism_Homo sapiens_hsa003801.31299337
39Huntingtons disease_Homo sapiens_hsa050161.29919142
40Fat digestion and absorption_Homo sapiens_hsa049751.29196376
41Cardiac muscle contraction_Homo sapiens_hsa042601.28709314
42Chemical carcinogenesis_Homo sapiens_hsa052041.25873768
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19916015
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.19860511
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19625344
46Dorso-ventral axis formation_Homo sapiens_hsa043201.19430634
47ABC transporters_Homo sapiens_hsa020101.19394094
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18643456
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.16726424
50Retinol metabolism_Homo sapiens_hsa008301.16620355
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15396754
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14231218
53Starch and sucrose metabolism_Homo sapiens_hsa005001.09534469
54Renin secretion_Homo sapiens_hsa049241.08696298
55Propanoate metabolism_Homo sapiens_hsa006401.08048250
56Gastric acid secretion_Homo sapiens_hsa049711.06952872
57Type II diabetes mellitus_Homo sapiens_hsa049301.05961176
58GnRH signaling pathway_Homo sapiens_hsa049121.05172569
59Glycosaminoglycan degradation_Homo sapiens_hsa005311.03784148
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03573618
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03054739
62Fatty acid degradation_Homo sapiens_hsa000711.01684013
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00312937
64Regulation of autophagy_Homo sapiens_hsa041400.99492003
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99373287
66Long-term depression_Homo sapiens_hsa047300.97729738
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97574330
68Gap junction_Homo sapiens_hsa045400.96970484
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95602121
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94292886
71Estrogen signaling pathway_Homo sapiens_hsa049150.93848213
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93393272
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92183513
74Tyrosine metabolism_Homo sapiens_hsa003500.92167284
75Alcoholism_Homo sapiens_hsa050340.91499411
76Protein export_Homo sapiens_hsa030600.91356793
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91101831
78Calcium signaling pathway_Homo sapiens_hsa040200.89047934
79Thyroid hormone synthesis_Homo sapiens_hsa049180.88754204
80Protein digestion and absorption_Homo sapiens_hsa049740.88488267
81Ether lipid metabolism_Homo sapiens_hsa005650.86686864
82Focal adhesion_Homo sapiens_hsa045100.83756249
83N-Glycan biosynthesis_Homo sapiens_hsa005100.82510812
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82033559
85cAMP signaling pathway_Homo sapiens_hsa040240.81659028
86Pancreatic secretion_Homo sapiens_hsa049720.81453087
87Melanogenesis_Homo sapiens_hsa049160.81105890
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79680473
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79631261
90Oxytocin signaling pathway_Homo sapiens_hsa049210.78526923
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78106593
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.77909083
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77333910
94Peroxisome_Homo sapiens_hsa041460.77221308
95Fatty acid metabolism_Homo sapiens_hsa012120.76212916
96Nitrogen metabolism_Homo sapiens_hsa009100.76027045
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75917226
98Phagosome_Homo sapiens_hsa041450.75428441
99Insulin signaling pathway_Homo sapiens_hsa049100.75304622
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.75241694
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72641195
102Linoleic acid metabolism_Homo sapiens_hsa005910.72596324
103Prolactin signaling pathway_Homo sapiens_hsa049170.72119122
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71887270
105Vitamin digestion and absorption_Homo sapiens_hsa049770.70987731
106Glioma_Homo sapiens_hsa052140.70699987
107Axon guidance_Homo sapiens_hsa043600.70226922
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68813128
109ErbB signaling pathway_Homo sapiens_hsa040120.66882841
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66547311
111Phenylalanine metabolism_Homo sapiens_hsa003600.65966739
112Thyroid cancer_Homo sapiens_hsa052160.65931620
113Dilated cardiomyopathy_Homo sapiens_hsa054140.64551751
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63984883
115PPAR signaling pathway_Homo sapiens_hsa033200.63947256
116Fatty acid biosynthesis_Homo sapiens_hsa000610.63344357
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63030560
118Prion diseases_Homo sapiens_hsa050200.62278991
119Endometrial cancer_Homo sapiens_hsa052130.61568805
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58778528
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58084955
122Basal transcription factors_Homo sapiens_hsa030220.57285774
123Sulfur metabolism_Homo sapiens_hsa009200.56774935
124Rheumatoid arthritis_Homo sapiens_hsa053230.56088941
125Glucagon signaling pathway_Homo sapiens_hsa049220.55546967
126Oocyte meiosis_Homo sapiens_hsa041140.55096549
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53196320
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51906129
129Hedgehog signaling pathway_Homo sapiens_hsa043400.49369204
130Ras signaling pathway_Homo sapiens_hsa040140.46130809
131Melanoma_Homo sapiens_hsa052180.45903988
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44172188
133TGF-beta signaling pathway_Homo sapiens_hsa043500.43659856
134Ovarian steroidogenesis_Homo sapiens_hsa049130.42263751
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41285288
136MAPK signaling pathway_Homo sapiens_hsa040100.38535893
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37672671
138Type I diabetes mellitus_Homo sapiens_hsa049400.37659011
139Inositol phosphate metabolism_Homo sapiens_hsa005620.36171602
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.35924698
141Sphingolipid metabolism_Homo sapiens_hsa006000.35361154
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.34873700
143Proteasome_Homo sapiens_hsa030500.33174899
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32307955
145Bile secretion_Homo sapiens_hsa049760.31575327
146Steroid biosynthesis_Homo sapiens_hsa001000.31002030
147Histidine metabolism_Homo sapiens_hsa003400.30533019
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.29665162
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28767305
150Circadian rhythm_Homo sapiens_hsa047100.26524030

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