SCNM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SCNM1 is a zinc finger protein and putative splicing factor. In mice, Scnm1 modifies phenotypic expression of Scn8a (MIM 600702) mutations (Buchner et al., 2003 [PubMed 12920299]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.39818656
2axon ensheathment in central nervous system (GO:0032291)5.39818656
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.29381981
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.23573645
5protein neddylation (GO:0045116)5.09200974
6ATP synthesis coupled proton transport (GO:0015986)4.90177032
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90177032
8chaperone-mediated protein transport (GO:0072321)4.54935951
9proteasome assembly (GO:0043248)4.49625108
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.38894237
11NADH dehydrogenase complex assembly (GO:0010257)4.38894237
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.38894237
13cullin deneddylation (GO:0010388)4.29955370
14respiratory electron transport chain (GO:0022904)4.28367793
15protein complex biogenesis (GO:0070271)4.22115799
16termination of RNA polymerase III transcription (GO:0006386)4.21179286
17transcription elongation from RNA polymerase III promoter (GO:0006385)4.21179286
18electron transport chain (GO:0022900)4.19158283
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.13635840
20protein deneddylation (GO:0000338)3.91869443
21mitochondrial respiratory chain complex assembly (GO:0033108)3.85841656
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.85701855
23pseudouridine synthesis (GO:0001522)3.77381519
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.73944638
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.73944638
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72249935
27GTP biosynthetic process (GO:0006183)3.68141729
28ribosomal small subunit biogenesis (GO:0042274)3.62112350
29ribosomal small subunit assembly (GO:0000028)3.62024138
307-methylguanosine mRNA capping (GO:0006370)3.57946901
31negative regulation of ligase activity (GO:0051352)3.53990401
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.53990401
337-methylguanosine RNA capping (GO:0009452)3.53380201
34RNA capping (GO:0036260)3.53380201
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.49630356
36fatty acid elongation (GO:0030497)3.47314074
37translational elongation (GO:0006414)3.46949649
38long-chain fatty acid biosynthetic process (GO:0042759)3.46833590
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45896684
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40043092
41regulation of cellular amino acid metabolic process (GO:0006521)3.34606652
42protein targeting to mitochondrion (GO:0006626)3.33698943
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.33473695
44transcription elongation from RNA polymerase I promoter (GO:0006362)3.32880136
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30937532
46platelet dense granule organization (GO:0060155)3.30749530
47ATP biosynthetic process (GO:0006754)3.30742305
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27476849
49respiratory chain complex IV assembly (GO:0008535)3.23363043
50base-excision repair, AP site formation (GO:0006285)3.21897185
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21754251
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21754251
53inner mitochondrial membrane organization (GO:0007007)3.21351541
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21107695
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21107695
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21107695
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18403420
58termination of RNA polymerase I transcription (GO:0006363)3.18301917
59establishment of protein localization to mitochondrion (GO:0072655)3.15595948
60positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.14469669
61presynaptic membrane assembly (GO:0097105)3.13417697
62proton transport (GO:0015992)3.13341648
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.13152974
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12743845
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11455021
66signal transduction involved in DNA damage checkpoint (GO:0072422)3.11455021
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10340372
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09273627
69protein-cofactor linkage (GO:0018065)3.09241588
70viral life cycle (GO:0019058)3.08797787
71translational initiation (GO:0006413)3.07781435
72peptidyl-histidine modification (GO:0018202)3.06905547
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06892640
74guanosine-containing compound biosynthetic process (GO:1901070)3.05757890
75hydrogen transport (GO:0006818)3.04921554
76UTP biosynthetic process (GO:0006228)3.01891009
77rRNA methylation (GO:0031167)3.01255327
78water-soluble vitamin biosynthetic process (GO:0042364)3.00336483
79DNA damage response, detection of DNA damage (GO:0042769)2.99651193
80transcription from RNA polymerase I promoter (GO:0006360)2.96804418
81L-methionine salvage (GO:0071267)2.96248354
82L-methionine biosynthetic process (GO:0071265)2.96248354
83amino acid salvage (GO:0043102)2.96248354
84tRNA processing (GO:0008033)2.95745775
85mannosylation (GO:0097502)2.95315514
86rRNA processing (GO:0006364)2.94921842
87viral transcription (GO:0019083)2.94499865
88deoxyribonucleotide catabolic process (GO:0009264)2.92514806
89presynaptic membrane organization (GO:0097090)2.91942841
90maturation of 5.8S rRNA (GO:0000460)2.91667837
91protein localization to cilium (GO:0061512)2.91232055
92rRNA modification (GO:0000154)2.90608166
93cellular protein complex disassembly (GO:0043624)2.90049849
94protein localization to mitochondrion (GO:0070585)2.89676676
95rRNA metabolic process (GO:0016072)2.89509159
96mitochondrial transport (GO:0006839)2.89325801
97cotranslational protein targeting to membrane (GO:0006613)2.89108556
98translational termination (GO:0006415)2.88976950
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88744769
100cytochrome complex assembly (GO:0017004)2.87883224
101ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86211579
102protein K6-linked ubiquitination (GO:0085020)2.84380676
103positive regulation of protein homodimerization activity (GO:0090073)2.83861855
104positive regulation of ligase activity (GO:0051351)2.82342443
105regulation of mitochondrial translation (GO:0070129)2.81720624
106translation (GO:0006412)2.81287793
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81239116
108GPI anchor biosynthetic process (GO:0006506)2.81230560
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81174741
110deoxyribose phosphate catabolic process (GO:0046386)2.80639592
111DNA deamination (GO:0045006)2.80192681
112viral mRNA export from host cell nucleus (GO:0046784)2.79790881
113spliceosomal snRNP assembly (GO:0000387)2.79058113
114protein targeting to ER (GO:0045047)2.79002639
115ribosomal large subunit biogenesis (GO:0042273)2.78875939
116SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78492430
117DNA double-strand break processing (GO:0000729)2.77954680
118microtubule polymerization or depolymerization (GO:0031109)2.77710585
119DNA catabolic process, exonucleolytic (GO:0000738)2.77607347
120cellular component biogenesis (GO:0044085)2.75318079
121maturation of SSU-rRNA (GO:0030490)2.74027124
122substantia nigra development (GO:0021762)2.73973842
123spliceosomal complex assembly (GO:0000245)2.73886164
124neurotransmitter uptake (GO:0001504)2.73579235
125neuron cell-cell adhesion (GO:0007158)2.73385845
126intracellular protein transmembrane import (GO:0044743)2.72759716
127hydrogen ion transmembrane transport (GO:1902600)2.71139809
128protein localization to endoplasmic reticulum (GO:0070972)2.71084718
129transcription initiation from RNA polymerase I promoter (GO:0006361)2.69059181
130regulation of cellular amine metabolic process (GO:0033238)2.68453222
131purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67474097
132regulation of collateral sprouting (GO:0048670)2.66272368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.81667487
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68187660
3* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.34970120
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.22117906
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.18463041
6* EST1_17652178_ChIP-ChIP_JURKAT_Human4.04013506
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.84464748
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68639724
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.38784733
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.38298436
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.30538640
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29231292
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04245986
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.96417276
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.63315029
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61639785
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.60832628
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54314513
19VDR_23849224_ChIP-Seq_CD4+_Human2.49805113
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.31288180
21* FOXP3_21729870_ChIP-Seq_TREG_Human2.20545304
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.18506509
23ZNF274_21170338_ChIP-Seq_K562_Hela2.17669482
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06104338
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91202996
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89802055
27IRF1_19129219_ChIP-ChIP_H3396_Human1.85388660
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.84510085
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78305277
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76175660
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71231086
32* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68771616
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67275476
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.63154512
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62809836
36TAF15_26573619_Chip-Seq_HEK293_Human1.58547829
37XRN2_22483619_ChIP-Seq_HELA_Human1.54520421
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53080258
39DCP1A_22483619_ChIP-Seq_HELA_Human1.52970406
40* ELK1_22589737_ChIP-Seq_MCF10A_Human1.49768646
41* TTF2_22483619_ChIP-Seq_HELA_Human1.49289279
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48132281
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44744224
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42912000
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41240732
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41181371
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38733358
48GABP_19822575_ChIP-Seq_HepG2_Human1.38169159
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36232290
50FUS_26573619_Chip-Seq_HEK293_Human1.33855146
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.29787906
52EZH2_22144423_ChIP-Seq_EOC_Human1.28605523
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26645800
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26189004
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26128552
56* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25914813
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25505260
58* TP53_22573176_ChIP-Seq_HFKS_Human1.25049477
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22007926
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20568900
61* KDM5A_27292631_Chip-Seq_BREAST_Human1.18342364
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15912451
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14313483
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13683402
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10298870
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.09889786
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09368810
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09095407
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.08095242
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06855731
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03181489
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02737059
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02087538
74MYC_18940864_ChIP-ChIP_HL60_Human1.01357652
75VDR_22108803_ChIP-Seq_LS180_Human1.00681537
76GBX2_23144817_ChIP-Seq_PC3_Human0.99718712
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98917413
78ER_23166858_ChIP-Seq_MCF-7_Human0.98510081
79* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96438882
80NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95754715
81IRF8_21731497_ChIP-ChIP_J774_Mouse0.95685111
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95465648
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94338512
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93482978
85FOXA1_25329375_ChIP-Seq_VCAP_Human0.91227943
86FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91227943
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90538746
88AR_20517297_ChIP-Seq_VCAP_Human0.90468432
89E2F7_22180533_ChIP-Seq_HELA_Human0.90075660
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89104105
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88990461
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88497406
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88398630
94EWS_26573619_Chip-Seq_HEK293_Human0.88392380
95* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88144272
96* SPI1_23547873_ChIP-Seq_NB4_Human0.88114855
97GATA3_26560356_Chip-Seq_TH2_Human0.87417776
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87209037
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86912019
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86163835
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85199915
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84505213
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.84083668
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83684480
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83230944
106NCOR_22424771_ChIP-Seq_293T_Human0.83104008
107RNF2_27304074_Chip-Seq_NSC_Mouse0.82391010
108SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81022121
109GATA3_21878914_ChIP-Seq_MCF-7_Human0.80285599
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.79914924
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79672062
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79286365
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78830962
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78798289
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78443311
116ERG_20517297_ChIP-Seq_VCAP_Human0.78280568
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77794387
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76999310
119NANOG_20526341_ChIP-Seq_ESCs_Human0.76542860
120* SOX2_16153702_ChIP-ChIP_HESCs_Human0.76452884
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74278717
122STAT1_20625510_ChIP-Seq_HELA_Human0.73340176
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72411195
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71610567
125* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71439597
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69534553
127KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67989462
128CIITA_25753668_ChIP-Seq_RAJI_Human0.67825441
129* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67646268
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67456430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.71659020
2MP0003880_abnormal_central_pattern3.42122764
3MP0001529_abnormal_vocalization3.31436804
4MP0001905_abnormal_dopamine_level2.98099793
5MP0001986_abnormal_taste_sensitivity2.89976685
6MP0001188_hyperpigmentation2.65000275
7MP0005423_abnormal_somatic_nervous2.63102236
8MP0003136_yellow_coat_color2.61833766
9MP0006292_abnormal_olfactory_placode2.56061542
10MP0003186_abnormal_redox_activity2.40369865
11MP0005171_absent_coat_pigmentation2.35544872
12MP0000920_abnormal_myelination2.18953908
13MP0008057_abnormal_DNA_replication2.11815980
14MP0005084_abnormal_gallbladder_morpholo2.08480678
15MP0004142_abnormal_muscle_tone2.00800392
16MP0009379_abnormal_foot_pigmentation1.83498018
17MP0008260_abnormal_autophagy1.68938962
18MP0002272_abnormal_nervous_system1.68590942
19MP0008872_abnormal_physiological_respon1.63167760
20MP0008877_abnormal_DNA_methylation1.62451288
21MP0008932_abnormal_embryonic_tissue1.58635219
22MP0005075_abnormal_melanosome_morpholog1.54636136
23MP0004381_abnormal_hair_follicle1.53998609
24MP0008058_abnormal_DNA_repair1.51235384
25MP0002938_white_spotting1.50893021
26MP0002102_abnormal_ear_morphology1.49072772
27MP0002837_dystrophic_cardiac_calcinosis1.47955003
28MP0001485_abnormal_pinna_reflex1.47035478
29MP0001486_abnormal_startle_reflex1.47027034
30MP0003718_maternal_effect1.46974815
31MP0006276_abnormal_autonomic_nervous1.45014122
32MP0001764_abnormal_homeostasis1.43226154
33MP0002064_seizures1.39526068
34MP0005174_abnormal_tail_pigmentation1.39129738
35MP0005671_abnormal_response_to1.39016884
36MP0008875_abnormal_xenobiotic_pharmacok1.38487209
37MP0002638_abnormal_pupillary_reflex1.34645130
38MP0002163_abnormal_gland_morphology1.33255027
39MP0001984_abnormal_olfaction1.32715323
40MP0005389_reproductive_system_phenotype1.32178267
41MP0004742_abnormal_vestibular_system1.32081091
42MP0009046_muscle_twitch1.31969690
43MP0005409_darkened_coat_color1.31964187
44MP0002277_abnormal_respiratory_mucosa1.31576888
45MP0009764_decreased_sensitivity_to1.30674536
46MP0003693_abnormal_embryo_hatching1.30004555
47MP0004957_abnormal_blastocyst_morpholog1.29045332
48MP0001919_abnormal_reproductive_system1.27630998
49MP0001968_abnormal_touch/_nociception1.25109003
50MP0003646_muscle_fatigue1.24426152
51MP0008995_early_reproductive_senescence1.23895367
52MP0009745_abnormal_behavioral_response1.22691715
53MP0001800_abnormal_humoral_immune1.22517178
54MP0002736_abnormal_nociception_after1.22485219
55MP0000372_irregular_coat_pigmentation1.22337729
56MP0010094_abnormal_chromosome_stability1.19048124
57MP0002734_abnormal_mechanical_nocicepti1.18603334
58MP0004147_increased_porphyrin_level1.18402355
59MP0004270_analgesia1.16303467
60MP0003195_calcinosis1.16235209
61MP0005410_abnormal_fertilization1.15978780
62MP0008789_abnormal_olfactory_epithelium1.15877028
63MP0002148_abnormal_hypersensitivity_rea1.15614972
64MP0001542_abnormal_bone_strength1.15404145
65MP0006036_abnormal_mitochondrial_physio1.15121034
66MP0005551_abnormal_eye_electrophysiolog1.14923981
67MP0003786_premature_aging1.14177612
68MP0005310_abnormal_salivary_gland1.13776261
69MP0005379_endocrine/exocrine_gland_phen1.13440697
70MP0006035_abnormal_mitochondrial_morpho1.12904831
71MP0000778_abnormal_nervous_system1.07598854
72MP0005000_abnormal_immune_tolerance1.07351980
73MP0002723_abnormal_immune_serum1.07178895
74MP0009697_abnormal_copulation1.06316662
75MP0002452_abnormal_antigen_presenting1.03902013
76MP0002009_preneoplasia1.03226333
77MP0002067_abnormal_sensory_capabilities1.03043100
78MP0003950_abnormal_plasma_membrane1.03040027
79MP0001440_abnormal_grooming_behavior1.01372759
80MP0000685_abnormal_immune_system1.00382206
81MP0002229_neurodegeneration1.00058133
82MP0003077_abnormal_cell_cycle0.99730069
83MP0002132_abnormal_respiratory_system0.99111025
84MP0001963_abnormal_hearing_physiology0.98591821
85MP0005645_abnormal_hypothalamus_physiol0.97832576
86MP0009785_altered_susceptibility_to0.96483347
87MP0003183_abnormal_peptide_metabolism0.95991606
88MP0002572_abnormal_emotion/affect_behav0.95567449
89MP0002420_abnormal_adaptive_immunity0.95115166
90MP0001819_abnormal_immune_cell0.94246950
91MP0002095_abnormal_skin_pigmentation0.93818961
92MP0003878_abnormal_ear_physiology0.93209419
93MP0005377_hearing/vestibular/ear_phenot0.93209419
94MP0002210_abnormal_sex_determination0.93156569
95MP0004134_abnormal_chest_morphology0.90889795
96MP0002752_abnormal_somatic_nervous0.89319988
97MP0009333_abnormal_splenocyte_physiolog0.88051020
98MP0005025_abnormal_response_to0.88045756
99MP0000358_abnormal_cell_content/0.88005272
100MP0001929_abnormal_gametogenesis0.87910878
101MP0002653_abnormal_ependyma_morphology0.86958622
102MP0002751_abnormal_autonomic_nervous0.86410885
103MP0003938_abnormal_ear_development0.86383097
104MP0004133_heterotaxia0.85735818
105MP0006072_abnormal_retinal_apoptosis0.85323295
106MP0001501_abnormal_sleep_pattern0.84455208
107MP0001790_abnormal_immune_system0.84156548
108MP0005387_immune_system_phenotype0.84156548
109MP0002160_abnormal_reproductive_system0.83460728
110MP0000631_abnormal_neuroendocrine_gland0.83255750
111MP0001970_abnormal_pain_threshold0.83209166
112MP0002876_abnormal_thyroid_physiology0.83139273
113MP0003634_abnormal_glial_cell0.82964219
114MP0003724_increased_susceptibility_to0.82788848
115MP0005253_abnormal_eye_physiology0.81883132
116MP0001853_heart_inflammation0.81437417
117MP0003787_abnormal_imprinting0.80818012
118MP0002138_abnormal_hepatobiliary_system0.80564930
119MP0000026_abnormal_inner_ear0.79008514
120MP0000015_abnormal_ear_pigmentation0.78818638
121MP0001293_anophthalmia0.78288772
122MP0003011_delayed_dark_adaptation0.77133600
123MP0008007_abnormal_cellular_replicative0.76930058
124MP0003763_abnormal_thymus_physiology0.76802613
125MP0000566_synostosis0.76734310
126MP0001845_abnormal_inflammatory_respons0.76183405
127MP0005646_abnormal_pituitary_gland0.76131435
128MP0002396_abnormal_hematopoietic_system0.75520199
129MP0000689_abnormal_spleen_morphology0.74956328
130MP0005332_abnormal_amino_acid0.74469476
131MP0003635_abnormal_synaptic_transmissio0.74449988
132MP0005394_taste/olfaction_phenotype0.74059950
133MP0005499_abnormal_olfactory_system0.74059950
134MP0003111_abnormal_nucleus_morphology0.73922827
135MP0000716_abnormal_immune_system0.73794622
136MP0001835_abnormal_antigen_presentation0.73516517
137MP0004145_abnormal_muscle_electrophysio0.73000617
138MP0002882_abnormal_neuron_morphology0.72125454
139MP0010386_abnormal_urinary_bladder0.70819514
140MP0000653_abnormal_sex_gland0.70058609
141MP0003436_decreased_susceptibility_to0.70057083
142MP0008873_increased_physiological_sensi0.70009657
143MP0001145_abnormal_male_reproductive0.69877605

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.19034742
2Mitochondrial inheritance (HP:0001427)4.72382755
3Abnormal mitochondria in muscle tissue (HP:0008316)4.48110280
4Hepatocellular necrosis (HP:0001404)4.43903984
5Progressive macrocephaly (HP:0004481)4.20881161
6Cerebral hypomyelination (HP:0006808)4.07849835
7Increased CSF lactate (HP:0002490)4.04185099
8Acute encephalopathy (HP:0006846)3.94588758
93-Methylglutaconic aciduria (HP:0003535)3.84331873
10Hepatic necrosis (HP:0002605)3.48769404
11Leukodystrophy (HP:0002415)3.43260851
12Increased hepatocellular lipid droplets (HP:0006565)3.40534519
13Increased serum pyruvate (HP:0003542)3.27806570
14Abnormality of glycolysis (HP:0004366)3.27806570
15Medial flaring of the eyebrow (HP:0010747)3.19871303
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.17066501
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.16996403
18Renal Fanconi syndrome (HP:0001994)3.16017807
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15928143
20Aplastic anemia (HP:0001915)3.02240442
21Parakeratosis (HP:0001036)3.01586861
22Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98291783
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98291783
24CNS hypomyelination (HP:0003429)2.93394346
25Lipid accumulation in hepatocytes (HP:0006561)2.83594069
26Abnormal hair whorl (HP:0010721)2.83142210
27Optic disc pallor (HP:0000543)2.82699620
28Increased serum lactate (HP:0002151)2.82622968
29Increased muscle lipid content (HP:0009058)2.81339170
30Respiratory failure (HP:0002878)2.72895099
31Exercise intolerance (HP:0003546)2.71370140
32Abnormal respiratory motile cilium morphology (HP:0005938)2.70057626
33Abnormal respiratory epithelium morphology (HP:0012253)2.70057626
34Congenital primary aphakia (HP:0007707)2.62931410
35Abnormal ciliary motility (HP:0012262)2.62276089
36Gait imbalance (HP:0002141)2.61992452
37Nephrogenic diabetes insipidus (HP:0009806)2.57536643
38Stomatitis (HP:0010280)2.50403140
39Lactic acidosis (HP:0003128)2.49223283
40Microvesicular hepatic steatosis (HP:0001414)2.49093625
41Hypothermia (HP:0002045)2.46416630
42Methylmalonic aciduria (HP:0012120)2.44147353
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42750853
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.42750853
45Type I transferrin isoform profile (HP:0003642)2.41246733
46Methylmalonic acidemia (HP:0002912)2.40337630
47Lethargy (HP:0001254)2.37575126
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35648697
49Congenital, generalized hypertrichosis (HP:0004540)2.31050737
50Pendular nystagmus (HP:0012043)2.28715681
51Abnormal respiratory motile cilium physiology (HP:0012261)2.28181676
52Pancreatic fibrosis (HP:0100732)2.25127435
53Exertional dyspnea (HP:0002875)2.24488499
54Pancytopenia (HP:0001876)2.23311642
55Cerebral edema (HP:0002181)2.22611202
56Congenital stationary night blindness (HP:0007642)2.21704965
57Abnormality of cells of the erythroid lineage (HP:0012130)2.19637791
58Vaginal atresia (HP:0000148)2.19029237
59Patchy hypopigmentation of hair (HP:0011365)2.17725749
60Abnormality of alanine metabolism (HP:0010916)2.17699908
61Hyperalaninemia (HP:0003348)2.17699908
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17699908
63Breast hypoplasia (HP:0003187)2.17025010
64Genital tract atresia (HP:0001827)2.16039516
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14721112
66Abnormal number of erythroid precursors (HP:0012131)2.13163832
67Birth length less than 3rd percentile (HP:0003561)2.12672262
68Nephronophthisis (HP:0000090)2.12522265
69Elevated erythrocyte sedimentation rate (HP:0003565)2.12050678
70Increased intramyocellular lipid droplets (HP:0012240)2.10838419
71Sensory axonal neuropathy (HP:0003390)2.09919308
72Macrocytic anemia (HP:0001972)2.09560240
73Reticulocytopenia (HP:0001896)2.08770960
74Pancreatic cysts (HP:0001737)2.05365766
75CNS demyelination (HP:0007305)2.03908215
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.02467678
77Absent/shortened dynein arms (HP:0200106)2.02467678
78Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02348452
79Absent thumb (HP:0009777)2.02040784
80Generalized aminoaciduria (HP:0002909)2.00272054
81Abnormality of renal resorption (HP:0011038)1.99075662
82White forelock (HP:0002211)1.98188779
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97678759
84Respiratory difficulties (HP:0002880)1.97342078
85Aplasia/hypoplasia of the uterus (HP:0008684)1.96890583
86Progressive microcephaly (HP:0000253)1.96753130
87Rough bone trabeculation (HP:0100670)1.95763154
88Peripheral hypomyelination (HP:0007182)1.95583304
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94846897
90Congenital ichthyosiform erythroderma (HP:0007431)1.94703025
91Abnormal rod and cone electroretinograms (HP:0008323)1.94208274
92Abnormal protein glycosylation (HP:0012346)1.93102944
93Abnormal glycosylation (HP:0012345)1.93102944
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93102944
95Abnormal protein N-linked glycosylation (HP:0012347)1.93102944
96Glycosuria (HP:0003076)1.92965111
97Abnormality of urine glucose concentration (HP:0011016)1.92965111
98Poor coordination (HP:0002370)1.92551309
99Sclerocornea (HP:0000647)1.92543356
100Asplenia (HP:0001746)1.91713401
101Rhinitis (HP:0012384)1.89522055
102Spastic paraparesis (HP:0002313)1.87414010
103True hermaphroditism (HP:0010459)1.86957591
104Abnormal pupillary function (HP:0007686)1.85887159
105Abolished electroretinogram (ERG) (HP:0000550)1.85395218
106Hypoplastic pelvis (HP:0008839)1.85271698
107Oral leukoplakia (HP:0002745)1.83625975
108Constricted visual fields (HP:0001133)1.83060493
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.81281377
110Meckel diverticulum (HP:0002245)1.81073180
111IgG deficiency (HP:0004315)1.80669268
112Abnormality of the ileum (HP:0001549)1.80013059
113Focal motor seizures (HP:0011153)1.79736648
114Adrenal hypoplasia (HP:0000835)1.77226011
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76045582
116Dicarboxylic aciduria (HP:0003215)1.76045582
117Esotropia (HP:0000565)1.75622686
118Muscle fiber atrophy (HP:0100295)1.75419791
119Hypoplasia of the uterus (HP:0000013)1.75006699
120Colon cancer (HP:0003003)1.74318452
121Cleft eyelid (HP:0000625)1.74189115
122Emotional lability (HP:0000712)1.74025497
123Abnormality of serum amino acid levels (HP:0003112)1.73976900
124Neutropenia (HP:0001875)1.72852724
125Abnormality of the renal medulla (HP:0100957)1.71564017
126Delusions (HP:0000746)1.69684675
127X-linked dominant inheritance (HP:0001423)1.69457075
128Blindness (HP:0000618)1.67216485
129Progressive external ophthalmoplegia (HP:0000590)1.66145511
130Abnormality of the septum pellucidum (HP:0007375)1.66009217
131Microretrognathia (HP:0000308)1.65727181
132Septo-optic dysplasia (HP:0100842)1.64379136
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.64164663
134Hyperglycinemia (HP:0002154)1.63678129
135Abnormality of midbrain morphology (HP:0002418)1.63460613
136Molar tooth sign on MRI (HP:0002419)1.63460613
137Anencephaly (HP:0002323)1.61602545
138Attenuation of retinal blood vessels (HP:0007843)1.61419353
139Abnormality of the preputium (HP:0100587)1.58536925
140Type II lissencephaly (HP:0007260)1.58422840
141Hepatosplenomegaly (HP:0001433)1.58354092
142Irregular epiphyses (HP:0010582)1.58145829
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57681949
144Absent epiphyses (HP:0010577)1.57681949
145Cystic liver disease (HP:0006706)1.57234893
146Poor speech (HP:0002465)1.57121788
147Type 2 muscle fiber atrophy (HP:0003554)1.57075750
148External ophthalmoplegia (HP:0000544)1.56589233
149Pallor (HP:0000980)1.55398024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.96467652
2BUB13.20701671
3CASK3.02067339
4STK162.77923310
5STK392.76750910
6SRPK12.59672579
7BCKDK2.54867911
8MST42.31392189
9NUAK12.27990873
10EIF2AK12.20449935
11TSSK62.18652185
12OXSR12.17148047
13TNIK2.13988286
14MAP3K121.97511733
15VRK11.93508738
16TLK11.85829633
17TAOK31.84456085
18CDC71.78244965
19TESK21.74026876
20MAP4K21.70077357
21BCR1.67524634
22WEE11.66514140
23WNK31.64499537
24NME11.63409666
25MAPKAPK51.62494604
26PLK41.60476633
27CDK191.59907935
28PNCK1.59673707
29INSRR1.58474353
30FRK1.52503821
31TRIM281.50279511
32IRAK41.49914198
33LIMK11.47675151
34ADRBK21.46176435
35AKT31.43523464
36GRK71.41074168
37MKNK11.34988994
38MAP2K71.31331640
39PKN11.28066563
40PBK1.27584745
41MUSK1.26728522
42ACVR1B1.19602479
43CSNK1G31.18897684
44BRSK21.18777475
45NEK61.16702220
46PDK21.14567362
47MYLK1.14440589
48TXK1.13703636
49CCNB11.13099485
50MKNK21.11446106
51IRAK21.11174309
52DYRK21.10817352
53NME21.10057523
54MAPK131.09852783
55EIF2AK31.09680743
56SIK31.06433799
57MAPKAPK31.05118730
58IRAK31.04213890
59ABL21.03835130
60CLK11.03122005
61BMPR21.00652644
62PIM21.00458228
63BRAF0.99069197
64BMPR1B0.92984782
65KDR0.91307420
66CDK80.86949002
67ARAF0.85235872
68EIF2AK20.83344385
69CSNK1G10.81996827
70TGFBR10.81616186
71ZAK0.79199475
72MAPK150.78620092
73CAMK2B0.77778348
74NEK10.75827641
75GRK10.73371966
76IRAK10.73309830
77UHMK10.72938260
78CSNK1A1L0.72543613
79RPS6KA50.72263626
80TAF10.72192958
81WNK40.71072888
82PIK3CG0.70236868
83ATR0.69143383
84PLK20.68990826
85PLK30.68718483
86GRK60.67680039
87YES10.62555597
88SYK0.61308634
89MAP3K110.60761356
90CSNK1G20.60432682
91OBSCN0.60346995
92PRPF4B0.59402604
93AURKB0.58479654
94GRK50.57979558
95PINK10.57503241
96DAPK10.57239162
97CDK30.56979320
98SGK2230.55946904
99SGK4940.55946904
100MARK30.54285755
101KIT0.53502021
102TESK10.53186042
103ROCK20.52820849
104AURKA0.51053256
105MAP3K140.49200855
106DYRK30.49184667
107PRKCG0.49128091
108CAMKK20.48970365
109PHKG20.48721406
110PHKG10.48721406
111STK240.48625611
112MAP3K60.47864435
113TNK20.47729427
114PRKCQ0.47567938
115TRPM70.47440006
116CSNK2A10.47410769
117NLK0.46949434
118ILK0.46147278
119BRSK10.45595510
120CSNK2A20.44315702
121ADRBK10.44084238
122IKBKE0.42731726
123PLK10.42370186
124CAMK2G0.41808977
125MAP4K10.40231967
126CAMK2D0.39707531
127TEC0.39456030
128PIM10.38604575
129CSNK1A10.38588920
130ITK0.38372366
131CAMK2A0.37831034
132DAPK30.37452659
133FES0.37427848
134CHUK0.36656929
135LRRK20.35229278
136PRKCI0.35188950
137LYN0.35138721
138PRKCE0.35026799
139MAP3K40.34926306
140IKBKB0.34461022
141PAK10.32368261
142CHEK20.32226869

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.67848260
2Proteasome_Homo sapiens_hsa030504.34617476
3Parkinsons disease_Homo sapiens_hsa050123.88643462
4Ribosome_Homo sapiens_hsa030103.85293481
5RNA polymerase_Homo sapiens_hsa030203.77444594
6Protein export_Homo sapiens_hsa030603.10481358
7Huntingtons disease_Homo sapiens_hsa050162.83788813
8Alzheimers disease_Homo sapiens_hsa050102.80681322
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45671488
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.30909808
11DNA replication_Homo sapiens_hsa030301.98980633
12Spliceosome_Homo sapiens_hsa030401.98554739
13Mismatch repair_Homo sapiens_hsa034301.92668091
14Pyrimidine metabolism_Homo sapiens_hsa002401.85862356
15Collecting duct acid secretion_Homo sapiens_hsa049661.85111743
16Basal transcription factors_Homo sapiens_hsa030221.82526877
17Homologous recombination_Homo sapiens_hsa034401.79157965
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75954007
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74008970
20Fatty acid elongation_Homo sapiens_hsa000621.72931763
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68619527
22Nucleotide excision repair_Homo sapiens_hsa034201.57535272
23Vitamin B6 metabolism_Homo sapiens_hsa007501.51011233
24Cardiac muscle contraction_Homo sapiens_hsa042601.49058693
25One carbon pool by folate_Homo sapiens_hsa006701.42288782
26Purine metabolism_Homo sapiens_hsa002301.38188801
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31567578
28Ether lipid metabolism_Homo sapiens_hsa005651.31378882
29Fanconi anemia pathway_Homo sapiens_hsa034601.26175956
30Base excision repair_Homo sapiens_hsa034101.24208381
31Phototransduction_Homo sapiens_hsa047441.17909965
32RNA degradation_Homo sapiens_hsa030181.16114523
33Non-homologous end-joining_Homo sapiens_hsa034501.14262363
34Rheumatoid arthritis_Homo sapiens_hsa053231.10325627
35Sphingolipid metabolism_Homo sapiens_hsa006001.10067733
36RNA transport_Homo sapiens_hsa030131.09304718
37Steroid biosynthesis_Homo sapiens_hsa001001.08304107
38Vibrio cholerae infection_Homo sapiens_hsa051101.05118984
39Arachidonic acid metabolism_Homo sapiens_hsa005901.04381349
40Selenocompound metabolism_Homo sapiens_hsa004501.03520700
41Type I diabetes mellitus_Homo sapiens_hsa049401.01504366
42Autoimmune thyroid disease_Homo sapiens_hsa053200.99988424
43Allograft rejection_Homo sapiens_hsa053300.97285912
44Nitrogen metabolism_Homo sapiens_hsa009100.96711910
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91126406
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89383246
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87789031
48Primary immunodeficiency_Homo sapiens_hsa053400.83265854
49Regulation of autophagy_Homo sapiens_hsa041400.81884872
50Cell cycle_Homo sapiens_hsa041100.80962746
51Epstein-Barr virus infection_Homo sapiens_hsa051690.79133480
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77824837
53Peroxisome_Homo sapiens_hsa041460.77461857
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75077400
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74591395
56Linoleic acid metabolism_Homo sapiens_hsa005910.73915517
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71496675
58Folate biosynthesis_Homo sapiens_hsa007900.70658952
59Metabolic pathways_Homo sapiens_hsa011000.67742837
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67509902
61Tryptophan metabolism_Homo sapiens_hsa003800.67323836
62Butanoate metabolism_Homo sapiens_hsa006500.67098157
63Asthma_Homo sapiens_hsa053100.65226789
64Synaptic vesicle cycle_Homo sapiens_hsa047210.63791968
65Propanoate metabolism_Homo sapiens_hsa006400.63403525
66Glutathione metabolism_Homo sapiens_hsa004800.62979021
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61624813
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61186987
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56305834
70Nicotine addiction_Homo sapiens_hsa050330.53579998
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52998581
72Serotonergic synapse_Homo sapiens_hsa047260.51900323
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51162089
74Chemical carcinogenesis_Homo sapiens_hsa052040.49838191
75Phagosome_Homo sapiens_hsa041450.49677161
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.47923016
77Sulfur metabolism_Homo sapiens_hsa009200.47574858
78Graft-versus-host disease_Homo sapiens_hsa053320.45881184
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45221802
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.43572119
81mRNA surveillance pathway_Homo sapiens_hsa030150.42994341
82Hematopoietic cell lineage_Homo sapiens_hsa046400.41028148
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40920755
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40437105
85Caffeine metabolism_Homo sapiens_hsa002320.39843679
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39794248
87Sulfur relay system_Homo sapiens_hsa041220.38304809
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.35836755
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31304555
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30746481
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30605511
92Olfactory transduction_Homo sapiens_hsa047400.29776877
93p53 signaling pathway_Homo sapiens_hsa041150.29564580
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29322704
95Arginine and proline metabolism_Homo sapiens_hsa003300.28077266
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28007924
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27954474
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27675710
99Legionellosis_Homo sapiens_hsa051340.27310355
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26607093
101Taste transduction_Homo sapiens_hsa047420.25711542
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.25442299
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24419149
104Pentose phosphate pathway_Homo sapiens_hsa000300.24383599
105African trypanosomiasis_Homo sapiens_hsa051430.24166181
106Vitamin digestion and absorption_Homo sapiens_hsa049770.23822399
107Staphylococcus aureus infection_Homo sapiens_hsa051500.23220291
108Histidine metabolism_Homo sapiens_hsa003400.23025505
109Systemic lupus erythematosus_Homo sapiens_hsa053220.22939113
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22761698
111Oocyte meiosis_Homo sapiens_hsa041140.22472230
112Morphine addiction_Homo sapiens_hsa050320.20098922
113Viral myocarditis_Homo sapiens_hsa054160.19987577
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19688765
115Shigellosis_Homo sapiens_hsa051310.18639177
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.17609815
117Pyruvate metabolism_Homo sapiens_hsa006200.17489661
118Measles_Homo sapiens_hsa051620.16997760
119Antigen processing and presentation_Homo sapiens_hsa046120.16871948
120Mineral absorption_Homo sapiens_hsa049780.15187396
121N-Glycan biosynthesis_Homo sapiens_hsa005100.15021347
122Herpes simplex infection_Homo sapiens_hsa051680.13505523
123Alcoholism_Homo sapiens_hsa050340.12408166
124Pertussis_Homo sapiens_hsa051330.12318382
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11567788
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10914471
127Axon guidance_Homo sapiens_hsa043600.10790660
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07804727
129GABAergic synapse_Homo sapiens_hsa047270.07784583
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06162047

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