SCNN1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.34719354
2desmosome organization (GO:0002934)7.93213701
3surfactant homeostasis (GO:0043129)7.27579972
4cilium or flagellum-dependent cell motility (GO:0001539)6.56110778
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.23653481
6lung epithelium development (GO:0060428)5.87988690
7chemical homeostasis within a tissue (GO:0048875)5.78991066
8motile cilium assembly (GO:0044458)5.77365749
9cilium movement (GO:0003341)5.68417632
10hemidesmosome assembly (GO:0031581)5.38267008
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.34261853
12L-phenylalanine catabolic process (GO:0006559)5.34261853
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.25804304
14L-phenylalanine metabolic process (GO:0006558)5.25804304
15vitamin transmembrane transport (GO:0035461)5.09509312
16cysteine metabolic process (GO:0006534)5.01381428
17calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.89239970
18aromatic amino acid family catabolic process (GO:0009074)4.86526836
19sulfur amino acid catabolic process (GO:0000098)4.86043801
20regulation of water loss via skin (GO:0033561)4.75519099
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.74698495
22epithelial cilium movement (GO:0003351)4.73653623
23* multicellular organismal water homeostasis (GO:0050891)4.70214044
24drug catabolic process (GO:0042737)4.65873041
25O-glycan processing (GO:0016266)4.64529904
26establishment of apical/basal cell polarity (GO:0035089)4.62171053
27diterpenoid biosynthetic process (GO:0016102)4.59659861
28indolalkylamine catabolic process (GO:0046218)4.58002714
29tryptophan catabolic process (GO:0006569)4.58002714
30indole-containing compound catabolic process (GO:0042436)4.58002714
31epoxygenase P450 pathway (GO:0019373)4.57264308
32establishment of skin barrier (GO:0061436)4.51776013
33ethanol oxidation (GO:0006069)4.51479791
34glyoxylate metabolic process (GO:0046487)4.50800517
35lysine catabolic process (GO:0006554)4.43239485
36lysine metabolic process (GO:0006553)4.43239485
37kynurenine metabolic process (GO:0070189)4.40670556
38exogenous drug catabolic process (GO:0042738)4.34879651
39tryptophan metabolic process (GO:0006568)4.32151098
40keratinocyte proliferation (GO:0043616)4.24413197
41homocysteine metabolic process (GO:0050667)4.14271938
42alpha-linolenic acid metabolic process (GO:0036109)4.12766801
43urate metabolic process (GO:0046415)4.11223236
44intestinal epithelial cell development (GO:0060576)4.11125662
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09793479
46hormone catabolic process (GO:0042447)4.01550430
47negative regulation of fibrinolysis (GO:0051918)3.98209300
48phosphate ion transmembrane transport (GO:0035435)3.98097116
49glomerular epithelial cell development (GO:0072310)3.97465284
50drug transmembrane transport (GO:0006855)3.94856932
51bile acid biosynthetic process (GO:0006699)3.93741789
52epithelial cell-cell adhesion (GO:0090136)3.91286187
53drug metabolic process (GO:0017144)3.89197701
54response to xenobiotic stimulus (GO:0009410)3.85350826
55protein carboxylation (GO:0018214)3.85048879
56peptidyl-glutamic acid carboxylation (GO:0017187)3.85048879
57* water homeostasis (GO:0030104)3.84942810
58establishment of planar polarity (GO:0001736)3.84167538
59establishment of tissue polarity (GO:0007164)3.84167538
60flavonoid metabolic process (GO:0009812)3.83429232
61phosphate ion transport (GO:0006817)3.83202027
62negative regulation of keratinocyte proliferation (GO:0010839)3.81000661
63amino-acid betaine metabolic process (GO:0006577)3.79852449
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.79700657
65establishment of monopolar cell polarity (GO:0061162)3.79700657
66cellular modified amino acid catabolic process (GO:0042219)3.76172959
67urea cycle (GO:0000050)3.73173740
68urea metabolic process (GO:0019627)3.73173740
69regulation of cholesterol homeostasis (GO:2000188)3.72350332
70complement activation, alternative pathway (GO:0006957)3.69302884
71ethanol metabolic process (GO:0006067)3.64345276
72negative regulation of T cell differentiation in thymus (GO:0033085)3.63509725
73response to mercury ion (GO:0046689)3.63448645
74terpenoid biosynthetic process (GO:0016114)3.56900811
75xenobiotic catabolic process (GO:0042178)3.55780844
76tight junction assembly (GO:0070830)3.54522119
77regulation of protein activation cascade (GO:2000257)3.53676226
78one-carbon compound transport (GO:0019755)3.52234056
79axoneme assembly (GO:0035082)3.52104299
80regulation of fibrinolysis (GO:0051917)3.51419527
81serine family amino acid catabolic process (GO:0009071)3.51005560
82coenzyme catabolic process (GO:0009109)3.50510843
83aromatic amino acid family metabolic process (GO:0009072)3.46097640
84nitrogen cycle metabolic process (GO:0071941)3.41739457
85benzene-containing compound metabolic process (GO:0042537)3.41715341
86lateral sprouting from an epithelium (GO:0060601)3.41301127
87regulation of complement activation (GO:0030449)3.41277868
88pyrimidine-containing compound transmembrane transport (GO:0072531)3.40994205
89gap junction assembly (GO:0016264)3.40714725
90triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40304301
91primary alcohol catabolic process (GO:0034310)3.34244005
92bile acid metabolic process (GO:0008206)3.32800113
93oligosaccharide biosynthetic process (GO:0009312)3.32249609
94retinoic acid metabolic process (GO:0042573)3.29687659
95response to nitrosative stress (GO:0051409)3.29515937
96drug transport (GO:0015893)3.27861494
97short-chain fatty acid metabolic process (GO:0046459)3.27739655
98glutamate metabolic process (GO:0006536)3.26136429
99alpha-amino acid catabolic process (GO:1901606)3.24790143
100L-ascorbic acid metabolic process (GO:0019852)3.24424718
101regulation of keratinocyte proliferation (GO:0010837)3.23788767
102apical protein localization (GO:0045176)3.23128488
103* excretion (GO:0007588)3.22526919
104high-density lipoprotein particle remodeling (GO:0034375)3.18526268
105cellular amino acid catabolic process (GO:0009063)3.18358717
106left/right pattern formation (GO:0060972)3.17614815
107negative regulation of cholesterol transport (GO:0032375)3.17214524
108negative regulation of sterol transport (GO:0032372)3.17214524
109fatty acid oxidation (GO:0019395)3.16908239
110fatty acid beta-oxidation (GO:0006635)3.16515954
111sodium-independent organic anion transport (GO:0043252)3.13404271
112indolalkylamine metabolic process (GO:0006586)3.12081960
113keratinization (GO:0031424)3.10285451
114lipid oxidation (GO:0034440)3.10187488
115carnitine metabolic process (GO:0009437)3.08977063
116regulation of bile acid biosynthetic process (GO:0070857)3.08729808
117protein O-linked glycosylation (GO:0006493)3.05650303
118tyrosine metabolic process (GO:0006570)3.05329885
119planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02711215
120peptide catabolic process (GO:0043171)2.99553035
121cellular ketone body metabolic process (GO:0046950)2.99048641
122sphingomyelin metabolic process (GO:0006684)2.98796006
123serine family amino acid metabolic process (GO:0009069)2.98585368
124dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.96493027
125trivalent inorganic anion homeostasis (GO:0072506)2.95880973
126phosphate ion homeostasis (GO:0055062)2.95880973
127valine metabolic process (GO:0006573)2.95858887
128regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.93845816
129acetyl-CoA metabolic process (GO:0006084)2.93725616
130positive regulation of endothelial cell differentiation (GO:0045603)2.91512742
131imidazole-containing compound metabolic process (GO:0052803)2.91215167
132sulfate transmembrane transport (GO:1902358)2.90443975
133aspartate family amino acid catabolic process (GO:0009068)2.90009023
134regulation of triglyceride catabolic process (GO:0010896)2.89689217
135intestinal absorption (GO:0050892)2.88726324
136NADP metabolic process (GO:0006739)2.86992595
137establishment or maintenance of bipolar cell polarity (GO:0061245)2.86589354
138establishment or maintenance of apical/basal cell polarity (GO:0035088)2.86589354
139primary alcohol metabolic process (GO:0034308)2.86494816
140maintenance of gastrointestinal epithelium (GO:0030277)2.86482642
141cellular biogenic amine catabolic process (GO:0042402)2.86203549
142amine catabolic process (GO:0009310)2.86203549
143carboxylic acid catabolic process (GO:0046395)2.86161840
144organic acid catabolic process (GO:0016054)2.86161840
145glutathione derivative biosynthetic process (GO:1901687)2.85528014
146glutathione derivative metabolic process (GO:1901685)2.85528014
147cellular glucuronidation (GO:0052695)2.85262564
148fatty acid catabolic process (GO:0009062)2.84008608
149transepithelial transport (GO:0070633)2.83861257
150omega-hydroxylase P450 pathway (GO:0097267)2.83848034
151aldehyde catabolic process (GO:0046185)2.83352247
152bile acid and bile salt transport (GO:0015721)2.82894212
153monocarboxylic acid catabolic process (GO:0072329)2.81614339
154cell-cell junction assembly (GO:0007043)2.81155007
155regulation of endothelial cell differentiation (GO:0045601)2.81053753
156renal absorption (GO:0070293)2.79922033
157semaphorin-plexin signaling pathway (GO:0071526)2.79761431
158thyroid hormone generation (GO:0006590)2.78399505
159protein autoprocessing (GO:0016540)2.78391230
1602-oxoglutarate metabolic process (GO:0006103)2.78249922
161retinol metabolic process (GO:0042572)2.77875885
162sperm capacitation (GO:0048240)2.76751382
163regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76704081
164triglyceride homeostasis (GO:0070328)2.76307894
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.75637648
166regulation of ruffle assembly (GO:1900027)2.74628451
167asymmetric protein localization (GO:0008105)2.74432023
168branching involved in salivary gland morphogenesis (GO:0060445)2.73839777
169polarized epithelial cell differentiation (GO:0030859)2.67676421
170renal system development (GO:0072001)2.66485882
171keratinocyte differentiation (GO:0030216)2.65486788
172transcytosis (GO:0045056)2.63125001
173glutathione biosynthetic process (GO:0006750)2.62308374
174muscle cell migration (GO:0014812)2.61729940
175amyloid precursor protein catabolic process (GO:0042987)2.59023001
176ventricular cardiac muscle cell action potential (GO:0086005)2.57812086
177regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.56076991
178negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.54608033
179embryonic camera-type eye development (GO:0031076)2.53737659
180collecting duct development (GO:0072044)2.53224517
181epidermis development (GO:0008544)2.52603414
182epidermal cell differentiation (GO:0009913)2.51677899
183regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.47295409
184thyroid hormone metabolic process (GO:0042403)2.46820613
185lung secretory cell differentiation (GO:0061140)2.46355733
186branching involved in mammary gland duct morphogenesis (GO:0060444)2.46144512
187sulfur compound transport (GO:0072348)2.45531966
188phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.44845827
189nonribosomal peptide biosynthetic process (GO:0019184)2.44592794
190renal filtration (GO:0097205)2.44544802
191glucuronate metabolic process (GO:0019585)2.43961049
192uronic acid metabolic process (GO:0006063)2.43961049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.01491808
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.30230654
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.68486007
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.38577713
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.32392788
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.43061011
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25398535
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.05617986
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.00769004
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.77996245
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.54252261
12GATA1_22025678_ChIP-Seq_K562_Human2.50436710
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46537920
14CLOCK_20551151_ChIP-Seq_293T_Human2.41000758
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.38709707
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.32841333
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.24039673
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.03742410
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.00225999
20* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95408273
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90700426
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.71768033
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70505570
24DROSHA_22980978_ChIP-Seq_HELA_Human1.63396541
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.63254449
26* GATA4_25053715_ChIP-Seq_YYC3_Human1.61767850
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61543418
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57938567
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56247934
30TP63_22573176_ChIP-Seq_HFKS_Human1.52935443
31* FOXO3_23340844_ChIP-Seq_DLD1_Human1.51894272
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48865120
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.48863762
34* RACK7_27058665_Chip-Seq_MCF-7_Human1.48384924
35* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43579215
36SMC4_20622854_ChIP-Seq_HELA_Human1.43088559
37* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42001107
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40781805
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39980768
40* SOX2_20726797_ChIP-Seq_SW620_Human1.39366529
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37503690
42CTCF_27219007_Chip-Seq_Bcells_Human1.36314336
43* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35830468
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32598685
45LXR_22292898_ChIP-Seq_THP-1_Human1.31489613
46AR_21909140_ChIP-Seq_LNCAP_Human1.29377094
47ZNF263_19887448_ChIP-Seq_K562_Human1.28695550
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28641683
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25684448
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25546021
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24600239
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21334504
53* GATA6_25053715_ChIP-Seq_YYC3_Human1.20065382
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19906324
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16881317
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16370207
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15490800
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14353525
59P68_20966046_ChIP-Seq_HELA_Human1.14047215
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12813605
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12518190
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12503284
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10784344
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10177078
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09862043
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09848219
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09003820
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08044725
69* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07846518
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07182500
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06484555
72* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06384657
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06282412
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06282412
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06282412
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05806656
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05496815
78* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04886401
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.04853321
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04739910
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03543220
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03222735
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02752683
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.01367605
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01294648
86* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99816102
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99471436
88AHR_22903824_ChIP-Seq_MCF-7_Human0.99350768
89TP63_23658742_ChIP-Seq_EP156T_Human0.98332889
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97905084
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97327081
92TBX20_22080862_ChIP-Seq_HEART_Mouse0.97185047
93TBX20_22328084_ChIP-Seq_HEART_Mouse0.97185047
94GATA3_24758297_ChIP-Seq_MCF-7_Human0.95101934
95* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94831814
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94227220
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94137763
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90636198
99E2F1_20622854_ChIP-Seq_HELA_Human0.90387086
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.90093631
101SA1_27219007_Chip-Seq_ERYTHROID_Human0.89884286
102SA1_27219007_Chip-Seq_Bcells_Human0.88650215
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88537975
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88494648
105* CHD1_26751641_Chip-Seq_LNCaP_Human0.87514541
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87052213
107ELF5_23300383_ChIP-Seq_T47D_Human0.86698650
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84771028
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84704870
110* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84269681
111GATA1_19941826_ChIP-Seq_K562_Human0.84126757
112CTCF_20526341_ChIP-Seq_ESCs_Human0.83684476
113PHF8_20622854_ChIP-Seq_HELA_Human0.83184988
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82553850
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.82430764
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82271513
117KLF5_25053715_ChIP-Seq_YYC3_Human0.81781349
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81478437
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81477235
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81072851
121GATA2_19941826_ChIP-Seq_K562_Human0.79987972
122EGR1_19032775_ChIP-ChIP_M12_Human0.78063600
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77919746
124ATF3_27146783_Chip-Seq_COLON_Human0.77608640
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77544629
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76187961
127* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75401331
128* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75401331
129CJUN_26792858_Chip-Seq_BT549_Human0.74896474
130CREB1_26743006_Chip-Seq_LNCaP_Human0.73719899
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.73558383
132* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73546487
133KDM2B_26808549_Chip-Seq_K562_Human0.72432269
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71460604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.91466908
2MP0005360_urolithiasis5.53974366
3MP0008875_abnormal_xenobiotic_pharmacok4.93038575
4MP0005085_abnormal_gallbladder_physiolo4.20071547
5MP0005365_abnormal_bile_salt3.94929376
6MP0004782_abnormal_surfactant_physiolog3.77439539
7MP0002138_abnormal_hepatobiliary_system3.53655620
8MP0003941_abnormal_skin_development2.93668304
9MP0005083_abnormal_biliary_tract2.82323180
10MP0005377_hearing/vestibular/ear_phenot2.77138828
11MP0003878_abnormal_ear_physiology2.77138828
12MP0003191_abnormal_cellular_cholesterol2.69316745
13MP0003252_abnormal_bile_duct2.62918885
14MP0001958_emphysema2.55599211
15MP0003806_abnormal_nucleotide_metabolis2.53566413
16MP0005332_abnormal_amino_acid2.49177806
17MP0010329_abnormal_lipoprotein_level2.39040568
18MP0010234_abnormal_vibrissa_follicle2.38227211
19MP0010368_abnormal_lymphatic_system2.31163594
20MP0004019_abnormal_vitamin_homeostasis2.18499050
21MP0009780_abnormal_chondrocyte_physiolo2.15834851
22MP0000467_abnormal_esophagus_morphology2.14816736
23MP0010352_gastrointestinal_tract_polyps2.05110817
24MP0001666_abnormal_nutrient_absorption2.00807632
25MP0009643_abnormal_urine_homeostasis1.99131599
26MP0010030_abnormal_orbit_morphology1.90179330
27MP0009840_abnormal_foam_cell1.90046560
28MP0003705_abnormal_hypodermis_morpholog1.82105800
29MP0000762_abnormal_tongue_morphology1.80410457
30MP0005167_abnormal_blood-brain_barrier1.80058285
31MP0004043_abnormal_pH_regulation1.77834165
32MP0002132_abnormal_respiratory_system1.77770574
33MP0003195_calcinosis1.73010225
34MP0002254_reproductive_system_inflammat1.69024788
35MP0002796_impaired_skin_barrier1.63984598
36MP0002118_abnormal_lipid_homeostasis1.56914674
37MP0004264_abnormal_extraembryonic_tissu1.55265451
38MP0008004_abnormal_stomach_pH1.51725867
39MP0001756_abnormal_urination1.50361982
40MP0005319_abnormal_enzyme/_coenzyme1.48933116
41MP0000609_abnormal_liver_physiology1.47971060
42MP0004133_heterotaxia1.41234967
43MP0001765_abnormal_ion_homeostasis1.36707299
44MP0005636_abnormal_mineral_homeostasis1.36581546
45MP0003724_increased_susceptibility_to1.35916554
46MP0010771_integument_phenotype1.34104373
47MP0002653_abnormal_ependyma_morphology1.33670572
48MP0005257_abnormal_intraocular_pressure1.30851412
49MP0005076_abnormal_cell_differentiation1.27313391
50MP0009764_decreased_sensitivity_to1.26227971
51MP0003300_gastrointestinal_ulcer1.25123779
52MP0005409_darkened_coat_color1.24411954
53MP0008995_early_reproductive_senescence1.23530128
54MP0001664_abnormal_digestion1.23507249
55* MP0002136_abnormal_kidney_physiology1.22104936
56MP0000477_abnormal_intestine_morphology1.20049914
57MP0001879_abnormal_lymphatic_vessel1.18586468
58MP0002098_abnormal_vibrissa_morphology1.18192097
59MP0002249_abnormal_larynx_morphology1.17291396
60MP0005584_abnormal_enzyme/coenzyme_acti1.16441847
61MP0004858_abnormal_nervous_system1.14882395
62MP0003566_abnormal_cell_adhesion1.14597668
63MP0003186_abnormal_redox_activity1.13091133
64MP0001188_hyperpigmentation1.11421711
65MP0002277_abnormal_respiratory_mucosa1.04775780
66MP0009379_abnormal_foot_pigmentation1.04294354
67MP0001177_atelectasis1.01437732
68MP0003119_abnormal_digestive_system1.01190934
69MP0008961_abnormal_basal_metabolism0.99881707
70MP0008789_abnormal_olfactory_epithelium0.99579095
71MP0004272_abnormal_basement_membrane0.98666264
72MP0002133_abnormal_respiratory_system0.98608938
73MP0005388_respiratory_system_phenotype0.98608938
74MP0001485_abnormal_pinna_reflex0.97402467
75MP0010678_abnormal_skin_adnexa0.96066463
76MP0000627_abnormal_mammary_gland0.94833901
77MP0003453_abnormal_keratinocyte_physiol0.94750319
78MP0002909_abnormal_adrenal_gland0.93599403
79MP0003693_abnormal_embryo_hatching0.92056289
80MP0002295_abnormal_pulmonary_circulatio0.91713603
81MP0005670_abnormal_white_adipose0.90028710
82MP0005408_hypopigmentation0.86989414
83MP0003937_abnormal_limbs/digits/tail_de0.86175950
84MP0005275_abnormal_skin_tensile0.85976650
85MP0002089_abnormal_postnatal_growth/wei0.84885400
86MP0003075_altered_response_to0.84292668
87MP0003183_abnormal_peptide_metabolism0.83461368
88MP0003868_abnormal_feces_composition0.83349102
89MP0005023_abnormal_wound_healing0.83246239
90MP0005501_abnormal_skin_physiology0.83137951
91MP0002876_abnormal_thyroid_physiology0.81898402
92MP0005058_abnormal_lysosome_morphology0.81046635
93MP0000470_abnormal_stomach_morphology0.80905383
94MP0005164_abnormal_response_to0.79528307
95MP0000537_abnormal_urethra_morphology0.78539993
96MP0000681_abnormal_thyroid_gland0.77966774
97MP0003638_abnormal_response/metabolism_0.77864460
98MP0004883_abnormal_blood_vessel0.77323464
99MP0005647_abnormal_sex_gland0.76770794
100MP0002168_other_aberrant_phenotype0.76730537
101MP0000598_abnormal_liver_morphology0.75045655
102MP0002111_abnormal_tail_morphology0.74858110
103MP0005166_decreased_susceptibility_to0.74238804
104MP0005395_other_phenotype0.73985267
105MP0009931_abnormal_skin_appearance0.73887275
106MP0003890_abnormal_embryonic-extraembry0.72685273
107MP0003011_delayed_dark_adaptation0.72577004
108MP0005248_abnormal_Harderian_gland0.72272942
109MP0010155_abnormal_intestine_physiology0.71198465
110MP0000343_altered_response_to0.70023157
111MP0005451_abnormal_body_composition0.69490273
112MP0000249_abnormal_blood_vessel0.69377770
113MP0001346_abnormal_lacrimal_gland0.68838376
114MP0003938_abnormal_ear_development0.67291970
115MP0002135_abnormal_kidney_morphology0.66569652
116MP0001216_abnormal_epidermal_layer0.66474605
117MP0001764_abnormal_homeostasis0.66337230
118MP0003115_abnormal_respiratory_system0.66162469
119MP0002282_abnormal_trachea_morphology0.66070441
120MP0008469_abnormal_protein_level0.65234928
121MP0001849_ear_inflammation0.65129924
122MP0003866_abnormal_defecation0.64717035
123MP0000383_abnormal_hair_follicle0.64183610
124MP0002233_abnormal_nose_morphology0.63859560
125MP0000566_synostosis0.63155476
126MP0003315_abnormal_perineum_morphology0.62637621
127MP0000490_abnormal_crypts_of0.62105771
128* MP0009642_abnormal_blood_homeostasis0.61996930
129MP0002060_abnormal_skin_morphology0.59703641
130MP0002697_abnormal_eye_size0.59431566
131MP0003436_decreased_susceptibility_to0.59020303
132MP0005376_homeostasis/metabolism_phenot0.58385234
133MP0000377_abnormal_hair_follicle0.58345926
134MP0005394_taste/olfaction_phenotype0.57602291
135MP0005499_abnormal_olfactory_system0.57602291
136MP0001984_abnormal_olfaction0.56657731
137MP0000432_abnormal_head_morphology0.56123212
138MP0000678_abnormal_parathyroid_gland0.55722428
139MP0002084_abnormal_developmental_patter0.55700628
140MP0000579_abnormal_nail_morphology0.55008973
141MP0000604_amyloidosis0.54510753
142MP0009765_abnormal_xenobiotic_induced0.53799393
143MP0003329_amyloid_beta_deposits0.53009403
144MP0005220_abnormal_exocrine_pancreas0.51783071
145MP0009384_cardiac_valve_regurgitation0.51542334
146MP0004947_skin_inflammation0.51274866
147MP0004885_abnormal_endolymph0.50951524
148MP0009763_increased_sensitivity_to0.50427808
149MP0005165_increased_susceptibility_to0.48259253
150MP0000462_abnormal_digestive_system0.46744774
151MP0009053_abnormal_anal_canal0.45976512
152MP0005595_abnormal_vascular_smooth0.45162204

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.40658837
2Abnormal respiratory motile cilium morphology (HP:0005938)6.39274232
3Abnormal respiratory epithelium morphology (HP:0012253)6.39274232
4Abnormal respiratory motile cilium physiology (HP:0012261)6.18152333
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.07725904
6Absent/shortened dynein arms (HP:0200106)6.07725904
7Abnormal ciliary motility (HP:0012262)5.91309758
8* Chronic bronchitis (HP:0004469)5.86426133
9Rhinitis (HP:0012384)5.80686207
10Gout (HP:0001997)5.68948856
11Interstitial pulmonary disease (HP:0006530)5.50967328
12Deep venous thrombosis (HP:0002625)5.34330096
13* Hyperactive renin-angiotensin system (HP:0000841)5.15724002
14Hypokalemic alkalosis (HP:0001949)4.64094979
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.57732626
16Intrahepatic cholestasis (HP:0001406)4.54191920
17Abnormality of monocarboxylic acid metabolism (HP:0010996)4.44496721
18* Bronchiectasis (HP:0002110)4.32932363
19Pili torti (HP:0003777)3.97235422
20Xanthomatosis (HP:0000991)3.91111925
21Polycythemia (HP:0001901)3.84025851
22Nasal polyposis (HP:0100582)3.81497354
23Hyperglycinuria (HP:0003108)3.72186235
24Alkalosis (HP:0001948)3.71946426
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69729133
26Abnormality of purine metabolism (HP:0004352)3.67136985
27* Renal salt wasting (HP:0000127)3.65618581
28* Abnormality of chloride homeostasis (HP:0011422)3.59006169
29Complement deficiency (HP:0004431)3.52600381
30Esophageal varix (HP:0002040)3.46322496
31Tachypnea (HP:0002789)3.44764042
32Vascular calcification (HP:0004934)3.42705905
33Tubulointerstitial fibrosis (HP:0005576)3.38805948
34Increased purine levels (HP:0004368)3.34930826
35Hyperuricemia (HP:0002149)3.34930826
36Lip pit (HP:0100267)3.24808172
37Abnormality of glycine metabolism (HP:0010895)3.23205190
38Abnormality of serine family amino acid metabolism (HP:0010894)3.23205190
39Metabolic alkalosis (HP:0200114)3.15879421
40Hyperammonemia (HP:0001987)3.14410221
41Ketosis (HP:0001946)3.14339787
42Abnormal hair laboratory examination (HP:0003328)3.13575848
43Joint hemorrhage (HP:0005261)3.11912818
44Plantar hyperkeratosis (HP:0007556)3.11049716
45Cardiovascular calcification (HP:0011915)3.06317262
46Abnormality of nucleobase metabolism (HP:0010932)3.05452660
47Prolonged partial thromboplastin time (HP:0003645)3.01351788
48Flat acetabular roof (HP:0003180)2.98208782
49Onycholysis (HP:0001806)2.95761206
50Malnutrition (HP:0004395)2.95182138
51Hyperlipoproteinemia (HP:0010980)2.92553645
52Hypobetalipoproteinemia (HP:0003563)2.90292333
53* Hyperaldosteronism (HP:0000859)2.87249436
54Abnormality of permanent molar morphology (HP:0011071)2.87176169
55Abnormality of the dental root (HP:0006486)2.87176169
56Taurodontia (HP:0000679)2.87176169
57Fragile nails (HP:0001808)2.85291556
58Hyperglycinemia (HP:0002154)2.85190149
59Abnormality of renal excretion (HP:0011036)2.85039405
60Respiratory distress (HP:0002098)2.84867293
61Tubular atrophy (HP:0000092)2.81360824
62Visceral angiomatosis (HP:0100761)2.80868412
63Abnormality of the nasal mucosa (HP:0000433)2.77804665
64Delayed CNS myelination (HP:0002188)2.76961439
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.72653492
66Milia (HP:0001056)2.71412876
67Abnormality of the intrinsic pathway (HP:0010989)2.70093259
68Right ventricular cardiomyopathy (HP:0011663)2.69781186
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66797841
70Increased circulating renin level (HP:0000848)2.66591018
71Ketoacidosis (HP:0001993)2.66486882
72Abnormality of the dental pulp (HP:0006479)2.65489317
73Abnormality of the common coagulation pathway (HP:0010990)2.63882659
74Tetany (HP:0001281)2.62542060
75Male infertility (HP:0003251)2.61397961
76Spontaneous hematomas (HP:0007420)2.61173988
77Abnormality of fatty-acid metabolism (HP:0004359)2.61028348
78Abnormality of molar (HP:0011077)2.60658128
79Abnormality of molar morphology (HP:0011070)2.60658128
80Alopecia of scalp (HP:0002293)2.60486718
81Hemangiomatosis (HP:0007461)2.58294675
82Palmoplantar hyperkeratosis (HP:0000972)2.56655964
83* Abnormality of renin-angiotensin system (HP:0000847)2.55082619
84Fat malabsorption (HP:0002630)2.54724451
85Abnormality of complement system (HP:0005339)2.53107960
86Abnormal urine output (HP:0012590)2.51334022
87Pterygium (HP:0001059)2.51299624
88Popliteal pterygium (HP:0009756)2.49052124
89Abnormal cartilage morphology (HP:0002763)2.48696079
90Hematochezia (HP:0002573)2.45867899
91Hypoplasia of dental enamel (HP:0006297)2.41171438
92Infertility (HP:0000789)2.40128684
93Bronchomalacia (HP:0002780)2.37775518
94Palmar hyperkeratosis (HP:0010765)2.37399713
95* Bronchitis (HP:0012387)2.37070144
96Potter facies (HP:0002009)2.36322295
97Facial shape deformation (HP:0011334)2.36322295
98Abnormality of the salivary glands (HP:0010286)2.36065807
99Proximal tubulopathy (HP:0000114)2.35715334
100Hypomagnesemia (HP:0002917)2.34136285
101Epidermoid cyst (HP:0200040)2.32673322
102Decreased circulating renin level (HP:0003351)2.31886312
103Glomerulosclerosis (HP:0000096)2.31627056
104Recurrent otitis media (HP:0000403)2.26909911
105Amelogenesis imperfecta (HP:0000705)2.26826114
106Hepatocellular carcinoma (HP:0001402)2.25911910
107Hypolipoproteinemia (HP:0010981)2.25658781
108* Metabolic acidosis (HP:0001942)2.25200472
109Abnormality of nail color (HP:0100643)2.25186004
110Hypoglycemic coma (HP:0001325)2.24922640
111Hypoplastic labia majora (HP:0000059)2.23962641
112Spastic diplegia (HP:0001264)2.16250484
113Absent eyelashes (HP:0000561)2.15735223
114Nephrolithiasis (HP:0000787)2.15131666
115* Dehydration (HP:0001944)2.14946588
116Hypoalphalipoproteinemia (HP:0003233)2.14691275
117Tubulointerstitial nephritis (HP:0001970)2.14491487
118Cystic liver disease (HP:0006706)2.13861526
119Conjugated hyperbilirubinemia (HP:0002908)2.13148872
120Focal segmental glomerulosclerosis (HP:0000097)2.10926665
121Polyuria (HP:0000103)2.10166345
122Rickets (HP:0002748)2.09718992
123Hypokalemia (HP:0002900)2.09584674
124Abnormality of the distal phalanges of the toes (HP:0010182)2.09323523
125Hydroxyprolinuria (HP:0003080)2.08935971
126Abnormality of proline metabolism (HP:0010907)2.08935971
127Recurrent gram-negative bacterial infections (HP:0005420)2.06643396
128Amyloidosis (HP:0011034)2.05189066
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04286888
130Woolly hair (HP:0002224)2.02367681
131Occipital encephalocele (HP:0002085)2.00722814
132Ileus (HP:0002595)1.99752243
133Atelectasis (HP:0100750)1.97541364
134Steatorrhea (HP:0002570)1.96734144
135Sparse eyelashes (HP:0000653)1.95792082
136Abnormality of the labia majora (HP:0012881)1.94868877
137Chronic sinusitis (HP:0011109)1.94698329
138Oligodontia (HP:0000677)1.94349906
139Generalized aminoaciduria (HP:0002909)1.94263784
140Long toe (HP:0010511)1.93535471
141* Hyponatremia (HP:0002902)1.92007620
142* Hyperkalemia (HP:0002153)1.91532928
143Nail dystrophy (HP:0008404)1.90804752
144Ulnar bowing (HP:0003031)1.90035262
145Hemorrhage of the eye (HP:0011885)1.89782138
146Lymphangioma (HP:0100764)1.89621879
147Abnormality of magnesium homeostasis (HP:0004921)1.89468000
148Abnormal enzyme/coenzyme activity (HP:0012379)1.88182355
149Mitral stenosis (HP:0001718)1.87882041
150Recurrent sinusitis (HP:0011108)1.87866220
151Dicarboxylic aciduria (HP:0003215)1.86658865
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86658865
153Cerebral hemorrhage (HP:0001342)1.86130722
154Corneal erosion (HP:0200020)1.84760859
155Hypotrichosis (HP:0001006)1.83601598
156Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83505584
157Aplasia involving bones of the upper limbs (HP:0009823)1.83505124
158Aplasia of the phalanges of the hand (HP:0009802)1.83505124
159Aplasia involving bones of the extremities (HP:0009825)1.83505124
160Hypercholesterolemia (HP:0003124)1.83477099
161Chondrocalcinosis (HP:0000934)1.83286998
162Abnormality of the lacrimal duct (HP:0011481)1.83100642
163Labial hypoplasia (HP:0000066)1.81813740
164Advanced eruption of teeth (HP:0006288)1.81221427
165Short nail (HP:0001799)1.80779532
166Bifid scrotum (HP:0000048)1.77363842
167Thick nail (HP:0001805)1.76473702
168Abnormality of the nasal septum (HP:0000419)1.71120377
169Nasolacrimal duct obstruction (HP:0000579)1.70150559
170Hypoplastic female external genitalia (HP:0012815)1.68974948
171Abnormality of the gastric mucosa (HP:0004295)1.64661532
172Cone-rod dystrophy (HP:0000548)1.63594610
173Selective tooth agenesis (HP:0001592)1.63378507
174* Abnormality of sodium homeostasis (HP:0010931)1.63240568
175Abnormality of the renal medulla (HP:0100957)1.61475604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.42005905
2TIE13.46697026
3TGFBR23.18710771
4WNK42.96691881
5FGFR42.71091537
6LMTK22.46431749
7OXSR12.44857540
8BCKDK2.44410803
9TRIB32.30542540
10EPHB12.26325668
11MST1R2.10650403
12LRRK22.01506128
13EPHA22.00819538
14NME11.99952681
15GRK11.98618419
16SMG11.92274570
17SIK11.91485423
18MST41.85230008
19RIPK11.83908542
20FGFR21.83364785
21WNK31.82568538
22STK101.74707635
23PTK61.74020680
24GRK61.71199092
25PAK41.68234448
26STK391.64927308
27EPHB21.64383510
28MAP3K31.61966587
29FER1.54102892
30LATS11.49121000
31DAPK21.42519653
32PTK21.38755407
33MAP2K31.33748955
34PRKG21.30304638
35MAPK151.30237549
36MAP3K21.24982222
37ICK1.19498397
38GRK51.18559456
39MAP3K71.16151519
40FRK1.15667860
41CSK1.13949735
42PKN21.12684534
43EEF2K1.08240458
44FGFR31.08034848
45TAOK31.06545152
46MAP3K91.06150455
47MYLK1.00149088
48ZAP700.99815835
49TTK0.99600442
50CDK120.99418542
51PRKCI0.97752816
52PBK0.92349979
53MET0.89479282
54MAP2K20.89396263
55STK38L0.87386802
56KDR0.84822368
57GSK3A0.83803588
58MAP2K60.83591185
59ERBB20.82798282
60MATK0.80356190
61PDGFRA0.80103923
62EPHA30.78167582
63RPS6KB20.74257850
64STK240.73257558
65ERBB40.72029136
66MAP3K10.69447597
67SGK30.68904765
68KSR20.67790844
69MAP2K40.67192064
70TYK20.64703828
71ACVR1B0.63437224
72DYRK1B0.62854135
73JAK20.61604954
74TGFBR10.61297212
75BCR0.61273948
76PDPK10.60739484
77CDK60.60309977
78MAP3K110.60269862
79PDGFRB0.58917309
80CDC42BPA0.57112372
81MAP2K10.55644700
82TAOK10.54238294
83PRKD10.52293201
84EGFR0.51576916
85WNK10.51516779
86INSRR0.51076755
87MAPKAPK30.50163230
88NEK90.49001006
89MTOR0.47485608
90TESK10.45844848
91MAPK110.45636689
92PRKAA20.44822791
93ITK0.44641698
94PIK3CA0.44061446
95NTRK10.43878467
96CAMK40.43251158
97CSF1R0.43066895
98SGK2230.43029239
99SGK4940.43029239
100SIK30.42786019
101NEK20.41784539
102STK30.41682752
103TYRO30.40025792
104JAK10.40001520
105MAP3K100.36398885
106MAP3K60.36103541
107RPS6KA20.36063601
108TBK10.35037202
109ABL20.35010764
110MUSK0.34994681
111NEK60.34211992
112CAMK1D0.33091758
113IGF1R0.32737737
114MARK20.32283682
115PRKCZ0.31821118
116SGK20.31565026
117IRAK30.30691683
118PIK3CG0.29006873
119MAPK70.28676032
120MAP3K120.28122707
121BMX0.28113059
122FGFR10.28011485
123ADRBK10.27482374
124STK380.26454630
125BRSK20.25827691
126PRKD20.25592865
127CSNK1A10.25558691
128FLT30.24196750
129CHUK0.23689753
130SRC0.23095752
131TRPM70.21950523
132DMPK0.21928389
133VRK20.21753855
134PHKG10.21744118
135PHKG20.21744118
136IRAK10.20409897
137PRKCD0.20080817
138CDK70.19240385
139CDK90.18146549
140HIPK20.17053889
141MAPKAPK20.16779190
142ILK0.16549052
143CSNK1E0.16515051
144MELK0.16338170
145NLK0.15878753

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.42507955
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31039902
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.15446699
4Tryptophan metabolism_Homo sapiens_hsa003802.96747789
5Nitrogen metabolism_Homo sapiens_hsa009102.62542786
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57907028
7Fatty acid degradation_Homo sapiens_hsa000712.53828263
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.51105656
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.48935511
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.47904596
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45586825
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28384112
13Arginine biosynthesis_Homo sapiens_hsa002202.26913012
14Chemical carcinogenesis_Homo sapiens_hsa052042.21413339
15Complement and coagulation cascades_Homo sapiens_hsa046102.19284847
16Histidine metabolism_Homo sapiens_hsa003402.17254706
17Caffeine metabolism_Homo sapiens_hsa002322.10681285
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07748297
19Butanoate metabolism_Homo sapiens_hsa006501.99286083
20Peroxisome_Homo sapiens_hsa041461.97593363
21Bile secretion_Homo sapiens_hsa049761.85184013
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84275388
23Propanoate metabolism_Homo sapiens_hsa006401.82700917
24PPAR signaling pathway_Homo sapiens_hsa033201.75878617
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75605541
26Sulfur metabolism_Homo sapiens_hsa009201.75103027
27beta-Alanine metabolism_Homo sapiens_hsa004101.73190133
28Retinol metabolism_Homo sapiens_hsa008301.71327425
29Fatty acid metabolism_Homo sapiens_hsa012121.64495735
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56921913
31Selenocompound metabolism_Homo sapiens_hsa004501.55443871
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.53021390
33Phenylalanine metabolism_Homo sapiens_hsa003601.47004972
34Sphingolipid metabolism_Homo sapiens_hsa006001.43875512
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43154248
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36459938
37Pyruvate metabolism_Homo sapiens_hsa006201.28873408
38Staphylococcus aureus infection_Homo sapiens_hsa051501.26490510
39Glutathione metabolism_Homo sapiens_hsa004801.26422586
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25718788
41ABC transporters_Homo sapiens_hsa020101.23757090
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.23303846
43Tyrosine metabolism_Homo sapiens_hsa003501.22540910
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.16225432
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12097442
46Starch and sucrose metabolism_Homo sapiens_hsa005001.09220796
47Notch signaling pathway_Homo sapiens_hsa043301.06968872
48Fatty acid elongation_Homo sapiens_hsa000621.04906174
49Mineral absorption_Homo sapiens_hsa049781.04894488
50Vitamin digestion and absorption_Homo sapiens_hsa049771.02716898
51Carbon metabolism_Homo sapiens_hsa012000.99155833
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96039107
53Ether lipid metabolism_Homo sapiens_hsa005650.91872456
54Folate biosynthesis_Homo sapiens_hsa007900.90767600
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83033985
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.82188122
57Arginine and proline metabolism_Homo sapiens_hsa003300.81826864
58Fat digestion and absorption_Homo sapiens_hsa049750.81187821
59Hippo signaling pathway_Homo sapiens_hsa043900.80132282
60Glycerolipid metabolism_Homo sapiens_hsa005610.79539903
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79128875
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77830026
63Circadian rhythm_Homo sapiens_hsa047100.75621306
64Sulfur relay system_Homo sapiens_hsa041220.73778970
65N-Glycan biosynthesis_Homo sapiens_hsa005100.73750422
66Lysine degradation_Homo sapiens_hsa003100.72967585
67Biosynthesis of amino acids_Homo sapiens_hsa012300.70524954
68Vitamin B6 metabolism_Homo sapiens_hsa007500.70255384
69Pancreatic secretion_Homo sapiens_hsa049720.66520006
70* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65914908
71Basal cell carcinoma_Homo sapiens_hsa052170.63809844
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61475189
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60056130
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.58889487
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58364151
76Bladder cancer_Homo sapiens_hsa052190.58276595
77Pentose phosphate pathway_Homo sapiens_hsa000300.54447158
78Renin-angiotensin system_Homo sapiens_hsa046140.54004433
79Fructose and mannose metabolism_Homo sapiens_hsa000510.52199587
80Axon guidance_Homo sapiens_hsa043600.51449019
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47796093
82Fatty acid biosynthesis_Homo sapiens_hsa000610.46741493
83Steroid biosynthesis_Homo sapiens_hsa001000.45875389
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.45329465
85Insulin resistance_Homo sapiens_hsa049310.42703742
86Vibrio cholerae infection_Homo sapiens_hsa051100.41730764
87Lysosome_Homo sapiens_hsa041420.39636756
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.37930830
89ECM-receptor interaction_Homo sapiens_hsa045120.37667494
90Huntingtons disease_Homo sapiens_hsa050160.36784616
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36552814
92Adherens junction_Homo sapiens_hsa045200.36306770
93Thyroid hormone synthesis_Homo sapiens_hsa049180.34245805
94Choline metabolism in cancer_Homo sapiens_hsa052310.33831781
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31966095
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.31915642
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30111248
98Galactose metabolism_Homo sapiens_hsa000520.29854278
99Protein digestion and absorption_Homo sapiens_hsa049740.29331563
100Salivary secretion_Homo sapiens_hsa049700.29230054
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28805092
102Metabolic pathways_Homo sapiens_hsa011000.27744511
103Glucagon signaling pathway_Homo sapiens_hsa049220.26543750
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.26210602
105Tight junction_Homo sapiens_hsa045300.25926342
106Arachidonic acid metabolism_Homo sapiens_hsa005900.25499156
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24668177
108Other glycan degradation_Homo sapiens_hsa005110.22362924
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.22270745
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21901521
111Amoebiasis_Homo sapiens_hsa051460.20454394
112Hepatitis C_Homo sapiens_hsa051600.20265107
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16566676
114Focal adhesion_Homo sapiens_hsa045100.14394977
115Ovarian steroidogenesis_Homo sapiens_hsa049130.14374993
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14182501
117Linoleic acid metabolism_Homo sapiens_hsa005910.14132027
118Prion diseases_Homo sapiens_hsa050200.13677093
119AMPK signaling pathway_Homo sapiens_hsa041520.11468724
120Collecting duct acid secretion_Homo sapiens_hsa049660.10158658
121Pertussis_Homo sapiens_hsa051330.08824671
122Thyroid cancer_Homo sapiens_hsa052160.05667649
123Small cell lung cancer_Homo sapiens_hsa052220.04561310

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