SCNN1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.61868515
2cilium movement (GO:0003341)9.53024009
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.44579251
4epithelial cilium movement (GO:0003351)7.87468251
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.94945482
6endocrine pancreas development (GO:0031018)6.90176983
7primary alcohol catabolic process (GO:0034310)6.75888352
8axoneme assembly (GO:0035082)6.38724926
9ethanol metabolic process (GO:0006067)6.33875057
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.14976027
11protein maturation by protein folding (GO:0022417)6.01747152
12protein retention in ER lumen (GO:0006621)5.99405036
13peptide hormone processing (GO:0016486)5.93429628
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.91207594
15COPII vesicle coating (GO:0048208)5.86853835
16regulation of type B pancreatic cell apoptotic process (GO:2000674)5.82977981
17glandular epithelial cell differentiation (GO:0002067)5.71949286
18left/right pattern formation (GO:0060972)5.58686781
19desmosome organization (GO:0002934)5.56152258
20one-carbon compound transport (GO:0019755)5.52795939
21ethanol oxidation (GO:0006069)5.49550932
22type B pancreatic cell development (GO:0003323)5.32121243
23signal peptide processing (GO:0006465)5.30647329
24diterpenoid biosynthetic process (GO:0016102)5.28019023
25vitamin transmembrane transport (GO:0035461)5.16318308
26* multicellular organismal water homeostasis (GO:0050891)5.11100339
27exocrine pancreas development (GO:0031017)5.11064279
28sequestering of metal ion (GO:0051238)5.08978881
29activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.06331960
30glandular epithelial cell development (GO:0002068)5.02731322
31gonadal mesoderm development (GO:0007506)4.84279563
32positive regulation of nuclease activity (GO:0032075)4.79366349
33insulin secretion (GO:0030073)4.66836129
34sperm capacitation (GO:0048240)4.66186632
35keratinization (GO:0031424)4.64386598
36pyrimidine-containing compound transmembrane transport (GO:0072531)4.62945977
37negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.62088212
38oligosaccharide biosynthetic process (GO:0009312)4.56601841
39vesicle coating (GO:0006901)4.50557101
40ER overload response (GO:0006983)4.48387200
41establishment of skin barrier (GO:0061436)4.46474274
42regulation of water loss via skin (GO:0033561)4.40294599
43O-glycan processing (GO:0016266)4.39636710
44negative regulation of humoral immune response (GO:0002921)4.34036506
45regulation of nuclease activity (GO:0032069)4.33940902
46endoplasmic reticulum unfolded protein response (GO:0030968)4.29616875
47positive regulation of insulin secretion (GO:0032024)4.28872957
48* water homeostasis (GO:0030104)4.27024716
49toxin metabolic process (GO:0009404)4.21602309
50nitric oxide mediated signal transduction (GO:0007263)4.21310053
51negative regulation of glycoprotein biosynthetic process (GO:0010561)4.21120070
52cellular response to unfolded protein (GO:0034620)4.19214216
53lung epithelium development (GO:0060428)4.14535177
54cellular response to vitamin D (GO:0071305)4.13693418
55columnar/cuboidal epithelial cell development (GO:0002066)4.12180417
56establishment of tissue polarity (GO:0007164)4.05981251
57establishment of planar polarity (GO:0001736)4.05981251
58cellular response to topologically incorrect protein (GO:0035967)4.04906857
59regulation of insulin secretion (GO:0050796)4.04165498
60ER-nucleus signaling pathway (GO:0006984)4.01473621
61ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.99685181
62detection of calcium ion (GO:0005513)3.98323968
63left/right axis specification (GO:0070986)3.98048749
64thyroid hormone generation (GO:0006590)3.94847632
65calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.88980759
66surfactant homeostasis (GO:0043129)3.84010766
67regulation of cilium movement (GO:0003352)3.81532985
68microtubule bundle formation (GO:0001578)3.71527544
69regulation of interleukin-13 production (GO:0032656)3.70913517
70negative regulation of norepinephrine secretion (GO:0010700)3.70297130
71regulation of peptide hormone secretion (GO:0090276)3.68168486
72retinoic acid metabolic process (GO:0042573)3.67981873
73ventricular system development (GO:0021591)3.65068364
74regulation of peptide secretion (GO:0002791)3.61215521
75establishment of apical/basal cell polarity (GO:0035089)3.60734937
76regulation of interleukin-5 production (GO:0032674)3.59208195
77peptide hormone secretion (GO:0030072)3.58851136
78negative regulation of bone resorption (GO:0045779)3.58806157
79primary alcohol metabolic process (GO:0034308)3.57677794
80negative regulation of insulin secretion (GO:0046676)3.56063219
81L-alpha-amino acid transmembrane transport (GO:1902475)3.56018353
82peptide secretion (GO:0002790)3.50783551
83response to endoplasmic reticulum stress (GO:0034976)3.49348556
84positive regulation of peptide hormone secretion (GO:0090277)3.47177545
85bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44639389
86terpenoid biosynthetic process (GO:0016114)3.43602765
87ER to Golgi vesicle-mediated transport (GO:0006888)3.43407712
88intra-Golgi vesicle-mediated transport (GO:0006891)3.41237970
89positive regulation of peptide secretion (GO:0002793)3.34527589
90retinol metabolic process (GO:0042572)3.33927066
91peptide catabolic process (GO:0043171)3.32755871
92cellular zinc ion homeostasis (GO:0006882)3.31919343
93glutathione biosynthetic process (GO:0006750)3.31528573
94negative regulation of catecholamine secretion (GO:0033604)3.29156899
95renal absorption (GO:0070293)3.28097064
96hormone catabolic process (GO:0042447)3.28044478
97response to unfolded protein (GO:0006986)3.27559331
98phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.27300242
99polyol transport (GO:0015791)3.27079709
100induction of positive chemotaxis (GO:0050930)3.24348912
101protein N-linked glycosylation via asparagine (GO:0018279)3.24202060
102peptidyl-asparagine modification (GO:0018196)3.21848360
103response to hexose (GO:0009746)3.19173976
104negative regulation of B cell mediated immunity (GO:0002713)3.17018000
105negative regulation of immunoglobulin mediated immune response (GO:0002890)3.17018000
106response to topologically incorrect protein (GO:0035966)3.16583511
107regulation of hormone secretion (GO:0046883)3.15254858
108apoptotic cell clearance (GO:0043277)3.14835298
109positive regulation of glycolytic process (GO:0045821)3.13768383
110macroautophagy (GO:0016236)3.13286343
111negative regulation of glycoprotein metabolic process (GO:1903019)3.11139065
112response to glucose (GO:0009749)3.09610144
113negative regulation of peptide hormone secretion (GO:0090278)3.06671458
114thyroid hormone metabolic process (GO:0042403)3.05898005
115response to monosaccharide (GO:0034284)3.05721519
116apical protein localization (GO:0045176)3.05235946
117nucleoside diphosphate catabolic process (GO:0009134)3.04880441
118epithelial cell fate commitment (GO:0072148)3.03911159
119intestinal epithelial cell development (GO:0060576)3.03452107
120* excretion (GO:0007588)3.03363813
121glomerular epithelial cell development (GO:0072310)3.03181596
122regulation of autophagic vacuole assembly (GO:2000785)3.02792368
123peptide cross-linking (GO:0018149)3.02551915
124nonribosomal peptide biosynthetic process (GO:0019184)3.01768254
125protein localization to Golgi apparatus (GO:0034067)3.00714965
126tolerance induction (GO:0002507)3.00642988
127protein N-linked glycosylation (GO:0006487)2.98035486
128lipoxygenase pathway (GO:0019372)2.97564205
129cellular response to vitamin (GO:0071295)2.97213677
130regulation of peptide transport (GO:0090087)2.96851936
131response to xenobiotic stimulus (GO:0009410)2.96191461
132negative regulation of peptide secretion (GO:0002792)2.96170730
133cellular response to antibiotic (GO:0071236)2.94866658
134keratinocyte differentiation (GO:0030216)2.94392737
135intraciliary transport (GO:0042073)2.93067847
136Golgi organization (GO:0007030)2.92339333
137regulation of germinal center formation (GO:0002634)2.90640395
138astrocyte differentiation (GO:0048708)2.88771044
139protein O-linked glycosylation (GO:0006493)2.88205531
140peptide transport (GO:0015833)2.86457459
141amyloid precursor protein catabolic process (GO:0042987)2.86163849
142establishment of monopolar cell polarity (GO:0061162)2.84874114
143establishment or maintenance of monopolar cell polarity (GO:0061339)2.84874114
144negative regulation of bone remodeling (GO:0046851)2.84554548
145regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.84175113
146cellular response to glucagon stimulus (GO:0071377)2.83970945
147hypotonic response (GO:0006971)2.83659595
148hormone secretion (GO:0046879)2.83409279
149progesterone metabolic process (GO:0042448)2.80590138
150cilium organization (GO:0044782)2.79922667
151negative regulation of T cell differentiation in thymus (GO:0033085)2.79898186
152ear development (GO:0043583)2.79877966
153regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.79863399
154glucose homeostasis (GO:0042593)2.79680611
155carbohydrate homeostasis (GO:0033500)2.79680611
156chemical homeostasis within a tissue (GO:0048875)2.78656325
157pancreas development (GO:0031016)2.77690172
158glutathione derivative biosynthetic process (GO:1901687)2.77632618
159glutathione derivative metabolic process (GO:1901685)2.77632618
160regulation of oxidative phosphorylation (GO:0002082)2.76762583
161negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.76431756
162hydrogen peroxide biosynthetic process (GO:0050665)2.76311011
163regulation of energy homeostasis (GO:2000505)2.75653884
164negative regulation of inclusion body assembly (GO:0090084)2.75042261
165positive regulation of hormone secretion (GO:0046887)2.74282134
166glomerular filtration (GO:0003094)2.73424557
167cellular response to hepatocyte growth factor stimulus (GO:0035729)2.73239270
168response to hepatocyte growth factor (GO:0035728)2.73239270
169interleukin-1-mediated signaling pathway (GO:0070498)2.72805460
170cellular response to hexose stimulus (GO:0071331)2.72226645
171positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.71616560
172Golgi vesicle transport (GO:0048193)2.71212793
1733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.69175189
174purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.69175189
175intestinal absorption (GO:0050892)2.68148581
176cilium assembly (GO:0042384)2.67826309
177keratinocyte proliferation (GO:0043616)2.66237214
178positive regulation of tolerance induction (GO:0002645)2.64351341
179regulation of vacuole organization (GO:0044088)2.60870177
180renal filtration (GO:0097205)2.60357805
181epithelial cell-cell adhesion (GO:0090136)2.59866320
182* sodium ion homeostasis (GO:0055078)2.56458050
183iron ion import (GO:0097286)2.56226641
184carnitine metabolic process (GO:0009437)2.54162369
185epidermis development (GO:0008544)2.53500376
186glutathione metabolic process (GO:0006749)2.52318906
187epidermal cell differentiation (GO:0009913)2.51439021
188dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.50307430
189regulation of response to osmotic stress (GO:0047484)2.48256570
190positive regulation of p38MAPK cascade (GO:1900745)2.47779676
191sialylation (GO:0097503)2.46939380
192axonemal dynein complex assembly (GO:0070286)13.9169995
193cilium or flagellum-dependent cell motility (GO:0001539)11.8409239
194Golgi transport vesicle coating (GO:0048200)10.4727358
195COPI coating of Golgi vesicle (GO:0048205)10.4727358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.39818074
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.65817694
3GATA1_22025678_ChIP-Seq_K562_Human4.56355256
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.47131135
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.11250808
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.22121311
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.63428187
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.54354231
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.52457476
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.51761689
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.31320230
12CLOCK_20551151_ChIP-Seq_293T_Human2.10069291
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.03927235
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.94244717
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91096957
16* FOXO3_23340844_ChIP-Seq_DLD1_Human1.89457096
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87762514
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85372385
19* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.78999126
20AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.69647247
21* KLF5_25053715_ChIP-Seq_YYC3_Human1.69221238
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.68519755
23SMC4_20622854_ChIP-Seq_HELA_Human1.63971267
24* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62632551
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.62149170
26SOX2_20726797_ChIP-Seq_SW620_Human1.59838480
27* TP63_22573176_ChIP-Seq_HFKS_Human1.59364759
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.56444060
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54085517
30* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53075013
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52661146
32* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50887075
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50880076
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49854915
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47854303
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47554592
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47058603
38FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44348427
39OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.41442223
40FOXA1_25552417_ChIP-Seq_VCAP_Human1.37542476
41ZNF263_19887448_ChIP-Seq_K562_Human1.37394239
42FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35394650
43GATA1_19941826_ChIP-Seq_K562_Human1.35111462
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33321699
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30401286
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.25505426
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24339268
48STAT1_20625510_ChIP-Seq_HELA_Human1.21736435
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20749651
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20298654
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19998970
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19698131
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19682896
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.19181145
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18591742
56BCAT_22108803_ChIP-Seq_LS180_Human1.18057744
57GATA4_25053715_ChIP-Seq_YYC3_Human1.16792029
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16590652
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16416604
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15891885
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14775689
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14775689
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14499079
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.12923548
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.12850379
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.10897638
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.10897638
68REST_19997604_ChIP-ChIP_NEURONS_Mouse1.08937486
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.08903050
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08454809
71RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07637039
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07525940
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05574010
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04687571
75CTCF_27219007_Chip-Seq_Bcells_Human1.04523818
76* P68_20966046_ChIP-Seq_HELA_Human1.04035291
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03316547
78* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03166564
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02281224
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00974691
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00150626
82* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00111311
83* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99717577
84LXR_22292898_ChIP-Seq_THP-1_Human0.98265350
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97964658
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97721680
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97492221
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.96460754
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96240576
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95562198
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95453541
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.94934890
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94381163
94RACK7_27058665_Chip-Seq_MCF-7_Human0.94105884
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94067463
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93590338
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.92335695
98BCOR_27268052_Chip-Seq_Bcells_Human0.91966919
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91873477
100CTCF_20526341_ChIP-Seq_ESCs_Human0.91199367
101AHR_22903824_ChIP-Seq_MCF-7_Human0.90366527
102GATA6_25053715_ChIP-Seq_YYC3_Human0.90104778
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88746613
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88087952
105P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87535864
106GATA2_19941826_ChIP-Seq_K562_Human0.87209576
107ATF3_27146783_Chip-Seq_COLON_Human0.86546312
108* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86142818
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86004899
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85447480
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.84752659
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84371759
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83867736
114CEBPB_22108803_ChIP-Seq_LS180_Human0.83791337
115SA1_27219007_Chip-Seq_Bcells_Human0.83534650
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83500695
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83383707
118GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82432945
119TCF7_22412390_ChIP-Seq_EML_Mouse0.81726224
120BCL6_27268052_Chip-Seq_Bcells_Human0.81662690
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81188520
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.81001952
123KDM2B_26808549_Chip-Seq_K562_Human0.80923092
124* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80169392
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80005461
126TP63_23658742_ChIP-Seq_EP156T_Human0.79535893
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78908998
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78871657
129DROSHA_22980978_ChIP-Seq_HELA_Human0.78333036
130* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78291869
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78286300
132* FOXH1_21741376_ChIP-Seq_ESCs_Human0.76881863
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.76713971
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75437866
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.74947885
136ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.74771326
137RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74634557
138CHD1_26751641_Chip-Seq_LNCaP_Human0.74164965
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74110013
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73692578
141* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.73624156
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73375487
143STAT3_23295773_ChIP-Seq_U87_Human0.73068434
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72594298
145CREB1_26743006_Chip-Seq_LNCaP_Human0.72588017
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72328094
147REST_21632747_ChIP-Seq_MESCs_Mouse0.71999846
148MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.71722319
149REST_18959480_ChIP-ChIP_MESCs_Mouse0.71441126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.57574197
2MP0003283_abnormal_digestive_organ5.25864962
3MP0002796_impaired_skin_barrier4.33556133
4MP0009780_abnormal_chondrocyte_physiolo4.05871201
5MP0002693_abnormal_pancreas_physiology3.89753587
6MP0010386_abnormal_urinary_bladder3.88533617
7MP0002909_abnormal_adrenal_gland3.83104077
8* MP0004043_abnormal_pH_regulation3.82141693
9MP0000013_abnormal_adipose_tissue3.78157798
10MP0000678_abnormal_parathyroid_gland3.77729373
11MP0001944_abnormal_pancreas_morphology3.59920517
12MP0003195_calcinosis3.58399315
13MP0000566_synostosis3.35376931
14MP0003183_abnormal_peptide_metabolism3.04998041
15MP0005220_abnormal_exocrine_pancreas2.95579464
16MP0010678_abnormal_skin_adnexa2.87882265
17MP0005379_endocrine/exocrine_gland_phen2.80971152
18MP0004264_abnormal_extraembryonic_tissu2.49851407
19MP0002132_abnormal_respiratory_system2.47926636
20MP0002653_abnormal_ependyma_morphology2.42649685
21MP0003453_abnormal_keratinocyte_physiol2.34585484
22MP0005501_abnormal_skin_physiology2.26266592
23MP0000383_abnormal_hair_follicle2.25195046
24MP0000003_abnormal_adipose_tissue2.19509764
25MP0005275_abnormal_skin_tensile2.15953210
26MP0003300_gastrointestinal_ulcer2.12322815
27MP0002078_abnormal_glucose_homeostasis2.11177629
28MP0002837_dystrophic_cardiac_calcinosis2.05151127
29MP0002138_abnormal_hepatobiliary_system2.04310107
30MP0009379_abnormal_foot_pigmentation1.98281128
31* MP0001765_abnormal_ion_homeostasis1.95502867
32MP0000462_abnormal_digestive_system1.95007849
33* MP0009643_abnormal_urine_homeostasis1.94789797
34MP0010352_gastrointestinal_tract_polyps1.90100923
35MP0005645_abnormal_hypothalamus_physiol1.88329785
36MP0002638_abnormal_pupillary_reflex1.84702022
37MP0010155_abnormal_intestine_physiology1.81130716
38MP0000465_gastrointestinal_hemorrhage1.78241424
39MP0003303_peritoneal_inflammation1.76830189
40MP0000681_abnormal_thyroid_gland1.73164696
41MP0004782_abnormal_surfactant_physiolog1.72651266
42MP0002896_abnormal_bone_mineralization1.72017829
43MP0001756_abnormal_urination1.69142130
44MP0006072_abnormal_retinal_apoptosis1.68107185
45MP0002277_abnormal_respiratory_mucosa1.64069636
46MP0005058_abnormal_lysosome_morphology1.63607595
47MP0001216_abnormal_epidermal_layer1.59546881
48MP0000467_abnormal_esophagus_morphology1.58208302
49MP0006054_spinal_hemorrhage1.56754277
50MP0003191_abnormal_cellular_cholesterol1.56368177
51MP0000613_abnormal_salivary_gland1.54202374
52MP0002234_abnormal_pharynx_morphology1.51083710
53MP0005646_abnormal_pituitary_gland1.51074795
54MP0008004_abnormal_stomach_pH1.49640727
55MP0008961_abnormal_basal_metabolism1.46133121
56MP0004947_skin_inflammation1.45056816
57MP0002876_abnormal_thyroid_physiology1.41985952
58MP0002928_abnormal_bile_duct1.41756035
59* MP0003953_abnormal_hormone_level1.31071089
60MP0002060_abnormal_skin_morphology1.29584340
61MP0003868_abnormal_feces_composition1.28600910
62* MP0005636_abnormal_mineral_homeostasis1.28407378
63MP0008789_abnormal_olfactory_epithelium1.27020378
64MP0005165_increased_susceptibility_to1.23004170
65MP0001270_distended_abdomen1.22872615
66MP0010771_integument_phenotype1.21936436
67MP0000627_abnormal_mammary_gland1.21409841
68MP0003705_abnormal_hypodermis_morpholog1.19328611
69MP0003941_abnormal_skin_development1.16029845
70MP0001984_abnormal_olfaction1.15642861
71MP0003252_abnormal_bile_duct1.15034965
72MP0003172_abnormal_lysosome_physiology1.14544144
73MP0000538_abnormal_urinary_bladder1.11689088
74MP0000377_abnormal_hair_follicle1.11056803
75MP0001986_abnormal_taste_sensitivity1.09994109
76MP0003122_maternal_imprinting1.09816988
77MP0005023_abnormal_wound_healing1.09097773
78MP0005365_abnormal_bile_salt1.05900043
79MP0005408_hypopigmentation1.04193386
80MP0005257_abnormal_intraocular_pressure1.01974319
81MP0005085_abnormal_gallbladder_physiolo1.01801026
82MP0000579_abnormal_nail_morphology1.01567271
83MP0004885_abnormal_endolymph1.00857023
84MP0003959_abnormal_lean_body1.00429771
85MP0005310_abnormal_salivary_gland1.00144323
86MP0010234_abnormal_vibrissa_follicle1.00072723
87MP0000685_abnormal_immune_system0.99356888
88MP0002009_preneoplasia0.95708292
89MP0005375_adipose_tissue_phenotype0.95267157
90MP0003119_abnormal_digestive_system0.94612658
91MP0005409_darkened_coat_color0.94219231
92MP0008995_early_reproductive_senescence0.93782070
93MP0005666_abnormal_adipose_tissue0.93700060
94MP0001849_ear_inflammation0.92677678
95MP0005387_immune_system_phenotype0.91673396
96MP0001790_abnormal_immune_system0.91673396
97MP0005377_hearing/vestibular/ear_phenot0.91542756
98MP0003878_abnormal_ear_physiology0.91542756
99MP0002139_abnormal_hepatobiliary_system0.91422348
100MP0000762_abnormal_tongue_morphology0.90424987
101MP0005535_abnormal_body_temperature0.90328048
102MP0000477_abnormal_intestine_morphology0.89698441
103MP0000858_altered_metastatic_potential0.88833921
104MP0009333_abnormal_splenocyte_physiolog0.86616684
105MP0002163_abnormal_gland_morphology0.86291933
106MP0003656_abnormal_erythrocyte_physiolo0.83975421
107* MP0000230_abnormal_systemic_arterial0.83453704
108MP0002098_abnormal_vibrissa_morphology0.83409194
109MP0001346_abnormal_lacrimal_gland0.83188246
110MP0001666_abnormal_nutrient_absorption0.83046771
111MP0002133_abnormal_respiratory_system0.82545541
112MP0005388_respiratory_system_phenotype0.82545541
113MP0005076_abnormal_cell_differentiation0.82313175
114MP0001879_abnormal_lymphatic_vessel0.81662187
115MP0005164_abnormal_response_to0.78555028
116MP0002166_altered_tumor_susceptibility0.78051088
117MP0009931_abnormal_skin_appearance0.77533801
118MP0005395_other_phenotype0.77303995
119MP0000631_abnormal_neuroendocrine_gland0.76738384
120MP0002168_other_aberrant_phenotype0.75689560
121MP0004185_abnormal_adipocyte_glucose0.75300796
122MP0003890_abnormal_embryonic-extraembry0.73480784
123MP0001661_extended_life_span0.72783641
124MP0005499_abnormal_olfactory_system0.72050941
125MP0005394_taste/olfaction_phenotype0.72050941
126MP0002118_abnormal_lipid_homeostasis0.71234748
127MP0003866_abnormal_defecation0.70770906
128MP0005166_decreased_susceptibility_to0.70768922
129MP0001664_abnormal_digestion0.69691929
130MP0005025_abnormal_response_to0.69572276
131MP0001873_stomach_inflammation0.69561288
132MP0009672_abnormal_birth_weight0.68664849
133MP0003795_abnormal_bone_structure0.67907959
134MP0002295_abnormal_pulmonary_circulatio0.67560854
135MP0005503_abnormal_tendon_morphology0.66163482
136MP0004883_abnormal_blood_vessel0.65408414
137MP0003638_abnormal_response/metabolism_0.63929510
138MP0003045_fibrosis0.63210113
139MP0004019_abnormal_vitamin_homeostasis0.62707808
140MP0000367_abnormal_coat/_hair0.62148180
141MP0000639_abnormal_adrenal_gland0.62122587
142MP0003879_abnormal_hair_cell0.61139287
143MP0004272_abnormal_basement_membrane0.60073842
144* MP0009642_abnormal_blood_homeostasis0.59892941
145MP0005083_abnormal_biliary_tract0.59647317
146MP0000163_abnormal_cartilage_morphology0.58339524
147MP0002136_abnormal_kidney_physiology0.58120257
148MP0001502_abnormal_circadian_rhythm0.56367669
149MP0010368_abnormal_lymphatic_system0.55562278
150MP0005334_abnormal_fat_pad0.55473237
151MP0003566_abnormal_cell_adhesion0.54872687
152MP0005448_abnormal_energy_balance0.53966933
153MP0009703_decreased_birth_body0.53294657
154MP0004270_analgesia0.50504214
155MP0005332_abnormal_amino_acid0.49835677
156MP0008875_abnormal_xenobiotic_pharmacok0.48171787
157MP0005253_abnormal_eye_physiology0.46129547
158MP0001881_abnormal_mammary_gland0.42602532
159MP0001958_emphysema0.42005179
160MP0005670_abnormal_white_adipose0.41945632
161MP0005167_abnormal_blood-brain_barrier0.40910798
162MP0000470_abnormal_stomach_morphology0.40208277
163MP0001731_abnormal_postnatal_growth0.39883499
164MP0005367_renal/urinary_system_phenotyp0.36808811
165MP0000516_abnormal_urinary_system0.36808811

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.28372230
2Abnormal respiratory motile cilium morphology (HP:0005938)9.28372230
3Abnormal respiratory motile cilium physiology (HP:0012261)9.19807313
4Absent/shortened dynein arms (HP:0200106)9.12664265
5Dynein arm defect of respiratory motile cilia (HP:0012255)9.12664265
6Abnormal ciliary motility (HP:0012262)8.92602594
7Rhinitis (HP:0012384)8.53181941
8Hyperinsulinemic hypoglycemia (HP:0000825)7.47188432
9Hypoglycemic seizures (HP:0002173)6.98059962
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.64418028
11* Bronchiectasis (HP:0002110)6.55083922
12Symptomatic seizures (HP:0011145)6.50662328
13Nasal polyposis (HP:0100582)6.37798291
14Hypoglycemic coma (HP:0001325)6.21416931
15Abnormality of the nasal mucosa (HP:0000433)5.67612210
16Hyperglycemia (HP:0003074)4.79626300
17Insulin-resistant diabetes mellitus (HP:0000831)4.69630829
18Ketoacidosis (HP:0001993)4.53237961
19Abnormality of calcium-phosphate metabolism (HP:0100530)4.39947931
20* Bronchitis (HP:0012387)4.35955632
21Abnormal pancreas size (HP:0012094)4.23490472
22Abnormality of the pancreatic islet cells (HP:0006476)4.14551571
23Abnormality of endocrine pancreas physiology (HP:0012093)4.14551571
24Mucopolysacchariduria (HP:0008155)4.07127376
25Urinary glycosaminoglycan excretion (HP:0003541)4.07127376
26Recurrent sinusitis (HP:0011108)3.96823059
27Late onset (HP:0003584)3.80701026
28Pancreatic islet-cell hyperplasia (HP:0004510)3.80079989
29Recurrent otitis media (HP:0000403)3.74741281
30Dysostosis multiplex (HP:0000943)3.71299200
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.71027890
32Abnormality of polysaccharide metabolism (HP:0011012)3.71027890
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.71027890
34Large for gestational age (HP:0001520)3.67336380
35* Hypokalemia (HP:0002900)3.63710962
36Infertility (HP:0000789)3.55763551
37Chronic sinusitis (HP:0011109)3.53853705
38* Hyperactive renin-angiotensin system (HP:0000841)3.46068735
39Generalized aminoaciduria (HP:0002909)3.45332643
40Hyperparathyroidism (HP:0000843)3.39351439
41* Abnormality of renin-angiotensin system (HP:0000847)3.29914290
42Male infertility (HP:0003251)3.23396701
43Gout (HP:0001997)3.22484868
44Osteomalacia (HP:0002749)3.13549862
45* Abnormality of potassium homeostasis (HP:0011042)3.05316724
46* Decreased circulating renin level (HP:0003351)3.04589990
47Insulin resistance (HP:0000855)3.00698827
48* Abnormality of chloride homeostasis (HP:0011422)2.96141210
49Increased circulating renin level (HP:0000848)2.96103517
50Agitation (HP:0000713)2.95556847
51Conjugated hyperbilirubinemia (HP:0002908)2.88351604
52Hyperphosphatemia (HP:0002905)2.86460406
53Atelectasis (HP:0100750)2.80289691
54Flat acetabular roof (HP:0003180)2.78044935
55Tetany (HP:0001281)2.76813800
56Metabolic alkalosis (HP:0200114)2.74624506
57Abnormality of the intrinsic pathway (HP:0010989)2.68858642
58* Hypokalemic alkalosis (HP:0001949)2.63592406
59Hypothermia (HP:0002045)2.60836137
60Lip pit (HP:0100267)2.60268985
61Chronic otitis media (HP:0000389)2.57321273
62* Hyperaldosteronism (HP:0000859)2.56064873
63Unilateral renal agenesis (HP:0000122)2.55282394
64Vacuolated lymphocytes (HP:0001922)2.54693413
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49380984
66Ketosis (HP:0001946)2.49250714
67Tubulointerstitial nephritis (HP:0001970)2.48082387
68Cone-rod dystrophy (HP:0000548)2.39822510
69Exocrine pancreatic insufficiency (HP:0001738)2.36914185
70Intestinal atresia (HP:0011100)2.35962937
71Abnormality of purine metabolism (HP:0004352)2.33304594
72Retinal atrophy (HP:0001105)2.32762590
73Onycholysis (HP:0001806)2.32322763
74Abdominal distention (HP:0003270)2.31485179
75* Adrenal overactivity (HP:0002717)2.29381638
76* Renal salt wasting (HP:0000127)2.27997089
77Polyuria (HP:0000103)2.27607658
78Recurrent bronchitis (HP:0002837)2.25762900
79Thoracolumbar scoliosis (HP:0002944)2.25405778
80Prominent metopic ridge (HP:0005487)2.23787165
81Occipital encephalocele (HP:0002085)2.23345514
82Abnormal urine output (HP:0012590)2.22815358
83Goiter (HP:0000853)2.20829430
84Tachypnea (HP:0002789)2.20367571
85Right ventricular cardiomyopathy (HP:0011663)2.18094329
86Hypophosphatemia (HP:0002148)2.18073911
87Abnormality of renal excretion (HP:0011036)2.16919315
88Growth hormone excess (HP:0000845)2.16225783
89Progressive neurologic deterioration (HP:0002344)2.15171425
90Nuclear cataract (HP:0100018)2.14756464
91* Hyperkalemia (HP:0002153)2.14329430
92Absent eyebrow (HP:0002223)2.12943994
93Abnormal drinking behavior (HP:0030082)2.12150789
94Polydipsia (HP:0001959)2.12150789
95Hypomagnesemia (HP:0002917)2.09875099
96Protuberant abdomen (HP:0001538)2.05677442
97* Hypotension (HP:0002615)2.05587365
98Pili torti (HP:0003777)2.05127900
99Hypercortisolism (HP:0001578)2.04477286
100Limb hypertonia (HP:0002509)2.02859187
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02103745
102Abnormality of the distal phalanges of the toes (HP:0010182)2.00101307
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6236054
104Aplasia/Hypoplasia of the fovea (HP:0008060)1.99907636
105Hypoplasia of the fovea (HP:0007750)1.99907636
106Dysautonomia (HP:0002459)1.97570574
107Increased IgE level (HP:0003212)1.97239206
108* Hyponatremia (HP:0002902)1.95580437
109Interstitial pulmonary disease (HP:0006530)1.95462505
110Abnormality of magnesium homeostasis (HP:0004921)1.95105699
111Hyperphosphaturia (HP:0003109)1.94005600
112Congenital glaucoma (HP:0001087)1.93631728
113Abnormality of monocarboxylic acid metabolism (HP:0010996)1.92803440
114Abnormality of the dental pulp (HP:0006479)1.90432138
115Congenital ichthyosiform erythroderma (HP:0007431)1.88997357
116Abnormality of nail color (HP:0100643)1.87054197
117Abnormal biliary tract morphology (HP:0012440)1.84541981
118Abnormality of the metopic suture (HP:0005556)1.83595905
119Glycosuria (HP:0003076)1.82488196
120Abnormality of urine glucose concentration (HP:0011016)1.82488196
121Distal lower limb muscle weakness (HP:0009053)1.81154425
122Hypoplastic labia majora (HP:0000059)1.80721510
123* Chronic bronchitis (HP:0004469)1.80207452
124Congenital sensorineural hearing impairment (HP:0008527)1.79819680
125Thin bony cortex (HP:0002753)1.78970714
126Abnormality of the dental root (HP:0006486)1.78696728
127Taurodontia (HP:0000679)1.78696728
128Abnormality of permanent molar morphology (HP:0011071)1.78696728
129Abnormality of liposaccharide metabolism (HP:0010968)1.78618425
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.78618425
131Abnormality of glycolipid metabolism (HP:0010969)1.78618425
132Disproportionate short-trunk short stature (HP:0003521)1.78535504
133Cystic liver disease (HP:0006706)1.76831773
134Bell-shaped thorax (HP:0001591)1.75414793
135Restlessness (HP:0000711)1.74922910
136Abnormality of the fovea (HP:0000493)1.74324657
137Erythema (HP:0010783)1.72838362
138Hypotrichosis (HP:0001006)1.72412967
139Villous atrophy (HP:0011473)1.72298248
140Abnormality of small intestinal villus morphology (HP:0011472)1.72298248
141Pheochromocytoma (HP:0002666)1.72088543
142Menstrual irregularities (HP:0000858)1.71047528
143Plantar hyperkeratosis (HP:0007556)1.70420455
144Abnormality of the common coagulation pathway (HP:0010990)1.70331369
145Elevated alkaline phosphatase (HP:0003155)1.70082783
146True hermaphroditism (HP:0010459)1.69965095
147Abnormality of molar (HP:0011077)1.64732808
148Abnormality of molar morphology (HP:0011070)1.64732808
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63740602
150Chronic hepatic failure (HP:0100626)1.62331408
151* Abnormality of sodium homeostasis (HP:0010931)1.61644555
152Pancreatic fibrosis (HP:0100732)1.59092474
153Popliteal pterygium (HP:0009756)1.56862047
154Acanthosis nigricans (HP:0000956)1.55561723
155Tubulointerstitial fibrosis (HP:0005576)1.55245248
156Palmoplantar hyperkeratosis (HP:0000972)1.54771601
157Tubular atrophy (HP:0000092)1.54293019
158Abnormality of the salivary glands (HP:0010286)1.54232685
159Abnormal hair laboratory examination (HP:0003328)1.53441418
160Spinal cord compression (HP:0002176)1.49648003
161Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.49507206
162Absent frontal sinuses (HP:0002688)1.48456976
163Furrowed tongue (HP:0000221)1.47945326
164Flattened epiphyses (HP:0003071)1.45831306
165* Dehydration (HP:0001944)1.42276310
166Glucose intolerance (HP:0000833)1.39474212
167Palmar hyperkeratosis (HP:0010765)1.38580284
168Corneal erosion (HP:0200020)1.38076491
169* Alkalosis (HP:0001948)1.35064833
170Bifid scrotum (HP:0000048)1.34231746
171Malnutrition (HP:0004395)1.33304362
172Neonatal short-limb short stature (HP:0008921)1.32862680
173Hemorrhage of the eye (HP:0011885)1.32134461
174Alopecia of scalp (HP:0002293)1.31684414
175Nephritis (HP:0000123)1.30057629
176Ventricular fibrillation (HP:0001663)1.29757085
177Tubulointerstitial abnormality (HP:0001969)1.29341488
178* Nephropathy (HP:0000112)1.29048617
179Short thorax (HP:0010306)1.27751504
180Ridged nail (HP:0001807)1.27469032
181Vascular calcification (HP:0004934)1.27386155
182Short femoral neck (HP:0100864)1.26729502
183Postaxial foot polydactyly (HP:0001830)1.22600977
184Woolly hair (HP:0002224)1.22563163
185Obstructive sleep apnea (HP:0002870)1.22280122
186Intrahepatic cholestasis (HP:0001406)1.22058535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.69334988
2PASK5.67877879
3MAPK154.24285341
4MAP3K23.68942204
5MST43.66115727
6MAPKAPK33.48126938
7TAOK33.17110838
8MST1R3.13713826
9ERN13.05712835
10FRK3.03124710
11HIPK22.94600925
12WNK42.83131639
13EEF2K2.57717863
14PRKD32.48770581
15IRAK32.48173861
16SMG12.37407865
17STK242.16097391
18WNK31.99656568
19FLT31.93849437
20MAP3K31.89470438
21AKT31.85497454
22MAP3K11.79935885
23PRPF4B1.69586081
24NME11.68574187
25NTRK11.66500151
26PDGFRA1.65760861
27EPHA31.60539041
28IRAK11.54214657
29LRRK21.41447881
30PTK21.33684864
31PKN21.30197297
32PTK61.27306077
33TRIB31.22552267
34TBK11.20525246
35MET1.19614041
36SCYL21.18953376
37TIE11.09894552
38MAP2K21.08270615
39RPS6KB21.07101927
40UHMK11.06318875
41FER1.04760729
42CAMKK21.04443270
43CDC42BPA1.03668006
44TRPM71.01841984
45IRAK20.99872665
46MAP3K130.98929126
47PRKCH0.97680494
48PIK3CG0.96907783
49DYRK1B0.92051740
50EIF2AK30.91416142
51GRK60.91399351
52ICK0.87397665
53PAK30.85969966
54EPHB10.85052048
55SIK10.84748105
56MAP3K70.83301389
57NLK0.82458798
58STK100.81033016
59STK380.80495619
60TESK10.80235847
61EPHA20.78293848
62PAK40.77449120
63PIK3CA0.77425376
64RPS6KA20.76826936
65ZAP700.76385654
66FGFR40.76357619
67BCKDK0.75990783
68NTRK30.75107088
69PRKD20.74003685
70LMTK20.71078886
71STK390.69955086
72PRKAA20.69527075
73TAOK10.67531284
74PRKCI0.67241976
75ERBB30.66984908
76LATS10.66665585
77MAP3K60.65206213
78RET0.63311192
79SGK4940.62137078
80SGK2230.62137078
81TYK20.60465210
82STK38L0.59933129
83MAP2K60.59706983
84PRKCE0.58886396
85WNK10.58618094
86IRAK40.56710555
87YES10.55089485
88TGFBR20.54194928
89SIK30.53246379
90JAK20.52874324
91SGK20.52804191
92PRKCD0.51969674
93PRKG20.51412309
94ARAF0.50793208
95TTK0.47708657
96IKBKE0.47527913
97RIPK40.46856326
98MAPKAPK50.46206043
99ITK0.45906552
100ERBB20.45344477
101BRAF0.45137708
102PDGFRB0.44726836
103NEK60.44577143
104CHUK0.44512733
105GSK3A0.44469184
106SGK30.43914479
107BRSK20.43133730
108FGFR30.42034765
109PRKD10.41440213
110PIM20.39637606
111PTK2B0.38811955
112BMPR1B0.36163359
113JAK10.35353029
114MAP3K140.34924045
115ADRBK10.34017125
116MAP2K10.33056419
117PRKAA10.33039075
118JAK30.31941470
119IGF1R0.31873307
120CSNK1A10.31749795
121PDK10.29513252
122RIPK10.29260573
123CDK120.28376687
124MAPKAPK20.27644551
125BLK0.27400328
126PRKACG0.27264838
127BCR0.25865426
128MTOR0.25339561
129MYLK0.25085958
130CSK0.25017218
131MELK0.24688425
132CDK60.24304100
133MAP3K120.23918663
134TEC0.23747325
135KSR20.23574514
136CAMK2D0.22874170
137GRK10.22225442
138PRKACA0.22218741
139MARK20.22157425
140SRC0.21873013
141OXSR10.21501187
142CAMK1G0.21135812
143TGFBR10.16879164
144MAP3K100.16777692
145MAP2K30.16750376
146PDPK10.16275403
147RPS6KB10.15802051
148BMPR20.14531357
149PRKCA0.12583884
150SGK10.10556261
151MAPK30.10541938

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.02404114
2Protein export_Homo sapiens_hsa030605.18849883
3Caffeine metabolism_Homo sapiens_hsa002323.75766854
4Sulfur metabolism_Homo sapiens_hsa009203.69148255
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.58282018
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.23663172
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.02744042
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.92231784
9Chemical carcinogenesis_Homo sapiens_hsa052042.89057675
10Insulin secretion_Homo sapiens_hsa049112.87070289
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.51208240
12Vibrio cholerae infection_Homo sapiens_hsa051102.41404788
13Type II diabetes mellitus_Homo sapiens_hsa049302.02085496
14Glutathione metabolism_Homo sapiens_hsa004801.94874675
15Lysosome_Homo sapiens_hsa041421.90508062
16beta-Alanine metabolism_Homo sapiens_hsa004101.90225981
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.87917045
18Retinol metabolism_Homo sapiens_hsa008301.85665320
19Selenocompound metabolism_Homo sapiens_hsa004501.80642083
20Nitrogen metabolism_Homo sapiens_hsa009101.79156876
21Other glycan degradation_Homo sapiens_hsa005111.76728261
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75131535
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.71416770
24Type I diabetes mellitus_Homo sapiens_hsa049401.64949013
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55079083
26Thyroid hormone synthesis_Homo sapiens_hsa049181.49091699
27N-Glycan biosynthesis_Homo sapiens_hsa005101.45583572
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.44867140
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.42684611
30Cocaine addiction_Homo sapiens_hsa050301.37770043
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37121860
32Arachidonic acid metabolism_Homo sapiens_hsa005901.32844771
33Tight junction_Homo sapiens_hsa045301.26277058
34Butanoate metabolism_Homo sapiens_hsa006501.25301072
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24945471
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24479122
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22951674
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19925495
39Hepatitis C_Homo sapiens_hsa051601.18245341
40Collecting duct acid secretion_Homo sapiens_hsa049661.17623109
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17555375
42Tryptophan metabolism_Homo sapiens_hsa003801.17418716
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16423870
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12020142
45Folate biosynthesis_Homo sapiens_hsa007901.08250765
46Pancreatic secretion_Homo sapiens_hsa049721.06798442
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05588524
48Fatty acid biosynthesis_Homo sapiens_hsa000611.02029186
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.01837478
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01706442
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.97895330
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97186661
53Insulin resistance_Homo sapiens_hsa049310.95625797
54Sphingolipid metabolism_Homo sapiens_hsa006000.94570209
55Notch signaling pathway_Homo sapiens_hsa043300.93628583
56ABC transporters_Homo sapiens_hsa020100.90988138
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90538804
58Amphetamine addiction_Homo sapiens_hsa050310.89234391
59Galactose metabolism_Homo sapiens_hsa000520.88615538
60Circadian rhythm_Homo sapiens_hsa047100.84481279
61Glucagon signaling pathway_Homo sapiens_hsa049220.83352255
62Prolactin signaling pathway_Homo sapiens_hsa049170.82347458
63PPAR signaling pathway_Homo sapiens_hsa033200.82334174
64Regulation of autophagy_Homo sapiens_hsa041400.81629652
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80295218
66* Taste transduction_Homo sapiens_hsa047420.79413472
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77513266
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76637851
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.74887971
70Choline metabolism in cancer_Homo sapiens_hsa052310.73021084
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72947528
72Salivary secretion_Homo sapiens_hsa049700.72432632
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69759047
74Prion diseases_Homo sapiens_hsa050200.66022748
75Histidine metabolism_Homo sapiens_hsa003400.61831140
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60758307
77Arginine and proline metabolism_Homo sapiens_hsa003300.60293332
78Mineral absorption_Homo sapiens_hsa049780.60035162
79Synaptic vesicle cycle_Homo sapiens_hsa047210.58984054
80* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55613145
81ECM-receptor interaction_Homo sapiens_hsa045120.54874496
82Starch and sucrose metabolism_Homo sapiens_hsa005000.54592396
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.54367473
84Dopaminergic synapse_Homo sapiens_hsa047280.52274657
85Protein digestion and absorption_Homo sapiens_hsa049740.51642309
86Circadian entrainment_Homo sapiens_hsa047130.50406401
87Glycerolipid metabolism_Homo sapiens_hsa005610.50066763
88Serotonergic synapse_Homo sapiens_hsa047260.49514517
89Estrogen signaling pathway_Homo sapiens_hsa049150.49233512
90Huntingtons disease_Homo sapiens_hsa050160.49206341
91Arginine biosynthesis_Homo sapiens_hsa002200.48613577
92Long-term potentiation_Homo sapiens_hsa047200.47269468
93Endocytosis_Homo sapiens_hsa041440.47180160
94Fatty acid elongation_Homo sapiens_hsa000620.46960351
95Renin secretion_Homo sapiens_hsa049240.45453551
96Phenylalanine metabolism_Homo sapiens_hsa003600.45146077
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44253851
98Acute myeloid leukemia_Homo sapiens_hsa052210.43374791
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42871918
100Insulin signaling pathway_Homo sapiens_hsa049100.42717830
101Cholinergic synapse_Homo sapiens_hsa047250.42309621
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41506208
103Fatty acid degradation_Homo sapiens_hsa000710.40827099
104Tyrosine metabolism_Homo sapiens_hsa003500.40759526
105Staphylococcus aureus infection_Homo sapiens_hsa051500.39510437
106Phagosome_Homo sapiens_hsa041450.39429068
107Influenza A_Homo sapiens_hsa051640.39162704
108Linoleic acid metabolism_Homo sapiens_hsa005910.37858339
109Thyroid cancer_Homo sapiens_hsa052160.37592404
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37545002
111Gastric acid secretion_Homo sapiens_hsa049710.36624915
112Amoebiasis_Homo sapiens_hsa051460.35359118
113Pertussis_Homo sapiens_hsa051330.35019384
114Dorso-ventral axis formation_Homo sapiens_hsa043200.34938021
115Pancreatic cancer_Homo sapiens_hsa052120.34659833
116GnRH signaling pathway_Homo sapiens_hsa049120.34524133
117Ether lipid metabolism_Homo sapiens_hsa005650.34130026
118Bladder cancer_Homo sapiens_hsa052190.34025578
119Autoimmune thyroid disease_Homo sapiens_hsa053200.33468663
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33372535
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32321629
122Allograft rejection_Homo sapiens_hsa053300.32198047
123VEGF signaling pathway_Homo sapiens_hsa043700.32104056
124Antigen processing and presentation_Homo sapiens_hsa046120.31251340
125Alcoholism_Homo sapiens_hsa050340.30737982
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30278817
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29693364
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29011857
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28702389
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28289984
131AMPK signaling pathway_Homo sapiens_hsa041520.28253633
132Apoptosis_Homo sapiens_hsa042100.28033582
133Fructose and mannose metabolism_Homo sapiens_hsa000510.27781549
134Bile secretion_Homo sapiens_hsa049760.27361374
135Rheumatoid arthritis_Homo sapiens_hsa053230.26942114
136mTOR signaling pathway_Homo sapiens_hsa041500.26570927
137Lysine degradation_Homo sapiens_hsa003100.26283603
138GABAergic synapse_Homo sapiens_hsa047270.25931397
139Peroxisome_Homo sapiens_hsa041460.25448563
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.25116641
141Fat digestion and absorption_Homo sapiens_hsa049750.24666425
142Prostate cancer_Homo sapiens_hsa052150.24626960
143Graft-versus-host disease_Homo sapiens_hsa053320.24249896
144Ovarian steroidogenesis_Homo sapiens_hsa049130.23357988
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23040674
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22450333
147cAMP signaling pathway_Homo sapiens_hsa040240.20141803
148Adherens junction_Homo sapiens_hsa045200.20057523
149Toxoplasmosis_Homo sapiens_hsa051450.19918899
150Inositol phosphate metabolism_Homo sapiens_hsa005620.18428502
151TNF signaling pathway_Homo sapiens_hsa046680.17863265
152Chronic myeloid leukemia_Homo sapiens_hsa052200.17789445
153Melanogenesis_Homo sapiens_hsa049160.15345791
154Renin-angiotensin system_Homo sapiens_hsa046140.15105557
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.14747584
156FoxO signaling pathway_Homo sapiens_hsa040680.14448340
157Endometrial cancer_Homo sapiens_hsa052130.13883737
158Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13557671
159Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12971611

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