SCNN1G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)9.88347966
2axonemal dynein complex assembly (GO:0070286)9.48362070
3cellular copper ion homeostasis (GO:0006878)8.84350967
4cilium or flagellum-dependent cell motility (GO:0001539)8.56069338
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.22950821
6cilium movement (GO:0003341)8.00616503
7chemical homeostasis within a tissue (GO:0048875)7.81863780
8epithelial cilium movement (GO:0003351)7.29857015
9copper ion homeostasis (GO:0055070)6.68662827
10motile cilium assembly (GO:0044458)6.58945352
11axoneme assembly (GO:0035082)6.46395396
12regulation of somitogenesis (GO:0014807)6.29088192
13positive regulation of endothelial cell differentiation (GO:0045603)5.89587105
14regulation of endothelial cell differentiation (GO:0045601)5.20663584
15response to copper ion (GO:0046688)5.12311276
16response to xenobiotic stimulus (GO:0009410)4.93878124
17regulation of metalloenzyme activity (GO:0048552)4.90697903
18copper ion transport (GO:0006825)4.81275679
19endothelial tube morphogenesis (GO:0061154)4.46719594
20morphogenesis of an endothelium (GO:0003159)4.46719594
21lymphangiogenesis (GO:0001946)4.44777144
22regulation of cilium movement (GO:0003352)4.44367577
23cellular response to nitric oxide (GO:0071732)4.27939296
24ethanol oxidation (GO:0006069)4.27919617
25protein localization to cilium (GO:0061512)4.22970949
26transepithelial transport (GO:0070633)4.21595636
27cilium organization (GO:0044782)4.18584032
28cilium assembly (GO:0042384)4.12307483
29norepinephrine metabolic process (GO:0042415)4.11775728
30sequestering of metal ion (GO:0051238)4.04984934
31regulation of vasculogenesis (GO:2001212)4.00255669
32blood vessel maturation (GO:0001955)3.98473361
33photoreceptor cell maintenance (GO:0045494)3.96667554
34intraciliary transport (GO:0042073)3.92308631
35toxin metabolic process (GO:0009404)3.90592789
36auditory receptor cell stereocilium organization (GO:0060088)3.89596271
37phosphate ion transport (GO:0006817)3.87913883
38regulation of oxidative phosphorylation (GO:0002082)3.86186911
39microtubule bundle formation (GO:0001578)3.84837616
40phosphate ion transmembrane transport (GO:0035435)3.83622064
41* excretion (GO:0007588)3.78185529
42peptide catabolic process (GO:0043171)3.76671297
43keratinization (GO:0031424)3.76666138
44lung lobe morphogenesis (GO:0060463)3.73364066
45hormone catabolic process (GO:0042447)3.71445128
46lung vasculature development (GO:0060426)3.70869882
47left/right pattern formation (GO:0060972)3.70565919
48tyrosine metabolic process (GO:0006570)3.70538431
49diterpenoid biosynthetic process (GO:0016102)3.69852405
50serotonin metabolic process (GO:0042428)3.67883070
51lung alveolus development (GO:0048286)3.64149673
52cellular zinc ion homeostasis (GO:0006882)3.63208489
53regulation of integrin-mediated signaling pathway (GO:2001044)3.61901041
54cilium morphogenesis (GO:0060271)3.54782958
55left/right axis specification (GO:0070986)3.53271853
56exogenous drug catabolic process (GO:0042738)3.49145526
57ethanol metabolic process (GO:0006067)3.40384424
58Golgi transport vesicle coating (GO:0048200)3.39077876
59COPI coating of Golgi vesicle (GO:0048205)3.39077876
60phosphate ion homeostasis (GO:0055062)3.38958031
61trivalent inorganic anion homeostasis (GO:0072506)3.38958031
62* sodium ion homeostasis (GO:0055078)3.37835106
63cellular component assembly involved in morphogenesis (GO:0010927)3.35426883
64intestinal epithelial cell development (GO:0060576)3.35023108
65drug catabolic process (GO:0042737)3.31607234
66keratinocyte development (GO:0003334)3.31203370
67cellular response to reactive nitrogen species (GO:1902170)3.27940344
68inner ear receptor stereocilium organization (GO:0060122)3.25777028
69blood vessel remodeling (GO:0001974)3.24343413
70tryptophan metabolic process (GO:0006568)3.23214376
71detection of light stimulus involved in visual perception (GO:0050908)3.21588942
72detection of light stimulus involved in sensory perception (GO:0050962)3.21588942
73primary alcohol catabolic process (GO:0034310)3.19388867
74respiratory gaseous exchange (GO:0007585)3.17536937
75response to pheromone (GO:0019236)3.14352316
76induction of positive chemotaxis (GO:0050930)3.14097988
77* multicellular organismal water homeostasis (GO:0050891)3.13920270
78renal absorption (GO:0070293)3.13770763
79response to nitric oxide (GO:0071731)3.06522688
80primary amino compound metabolic process (GO:1901160)3.05198233
81respiratory tube development (GO:0030323)3.04640320
82retinal cone cell development (GO:0046549)3.00851635
83bicarbonate transport (GO:0015701)3.00532175
84artery development (GO:0060840)3.00030029
85epithelial cell maturation (GO:0002070)2.99697180
86virion attachment to host cell (GO:0019062)2.98759212
87adhesion of symbiont to host cell (GO:0044650)2.98759212
88nonmotile primary cilium assembly (GO:0035058)2.98693376
89cell projection assembly (GO:0030031)2.95366496
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92115099
91establishment of apical/basal cell polarity (GO:0035089)2.91850514
92dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.91810210
93thyroid hormone metabolic process (GO:0042403)2.90338864
94urate metabolic process (GO:0046415)2.89490555
95extracellular matrix assembly (GO:0085029)2.89368963
96oligodendrocyte development (GO:0014003)2.87098579
97ventricular system development (GO:0021591)2.85813882
98negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83754422
99positive regulation of vasculogenesis (GO:2001214)2.83533510
100aldehyde catabolic process (GO:0046185)2.83432614
101terpenoid biosynthetic process (GO:0016114)2.83123523
102negative regulation of systemic arterial blood pressure (GO:0003085)2.83111853
103regulation of glomerular filtration (GO:0003093)2.81231217
104regulation of collateral sprouting (GO:0048670)2.80442490
105endothelial cell chemotaxis (GO:0035767)2.79211584
106one-carbon compound transport (GO:0019755)2.78818300
107wound healing, spreading of epidermal cells (GO:0035313)2.77590427
108hemidesmosome assembly (GO:0031581)2.75498907
109sodium-independent organic anion transport (GO:0043252)2.74330304
110pyrimidine-containing compound transmembrane transport (GO:0072531)2.74271903
111neural tube formation (GO:0001841)2.72294524
112regulation of microtubule-based movement (GO:0060632)2.72001512
113vascular endothelial growth factor signaling pathway (GO:0038084)2.71604740
114thyroid hormone generation (GO:0006590)2.71283353
115reflex (GO:0060004)2.70938236
116glomerular epithelial cell development (GO:0072310)2.70670646
117adenosine metabolic process (GO:0046085)2.69982595
118removal of superoxide radicals (GO:0019430)2.69455019
119cellular response to superoxide (GO:0071451)2.69455019
120cellular response to oxygen radical (GO:0071450)2.69455019
121drug metabolic process (GO:0017144)2.67784833
122embryonic foregut morphogenesis (GO:0048617)2.67423815
123retinal metabolic process (GO:0042574)2.67411152
124phosphatidylinositol acyl-chain remodeling (GO:0036149)2.66427920
125benzene-containing compound metabolic process (GO:0042537)2.66028572
126calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.65497941
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62505903
128retinoic acid metabolic process (GO:0042573)2.62484885
129vitamin transmembrane transport (GO:0035461)2.62168550
130aminoglycoside antibiotic metabolic process (GO:0030647)2.62005730
131centriole assembly (GO:0098534)2.61688152
132renal system process involved in regulation of blood volume (GO:0001977)2.61149702
133signal peptide processing (GO:0006465)2.61091718
134negative regulation of sodium ion transport (GO:0010766)2.59689612
135mesodermal cell differentiation (GO:0048333)2.59316171
136behavioral response to ethanol (GO:0048149)2.58761737
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57111037
138phosphatidylserine acyl-chain remodeling (GO:0036150)2.56595828
139regulation of hippo signaling (GO:0035330)2.55928035
140zinc ion homeostasis (GO:0055069)2.54832522
141cellular ketone body metabolic process (GO:0046950)2.54606340
142ganglion development (GO:0061548)2.53978773
143glomerular visceral epithelial cell development (GO:0072015)2.53624087
144regulation of interleukin-13 production (GO:0032656)2.52524085
145endothelial cell differentiation (GO:0045446)2.51895812
146protein polyglutamylation (GO:0018095)2.51783911
147midgut development (GO:0007494)2.51113024
148response to mercury ion (GO:0046689)2.51071806
149* water homeostasis (GO:0030104)2.50728939
150renal system development (GO:0072001)2.50316569
151keratinocyte proliferation (GO:0043616)2.50116591
152photoreceptor cell development (GO:0042461)2.49937161
153cellular anion homeostasis (GO:0030002)2.49810583
154centriole replication (GO:0007099)2.49491802
155positive regulation of embryonic development (GO:0040019)2.49216824
156cornea development in camera-type eye (GO:0061303)2.49053944
157spinal cord motor neuron differentiation (GO:0021522)2.48170706
158parturition (GO:0007567)2.46979177
159desmosome organization (GO:0002934)2.46901903
160positive regulation of p38MAPK cascade (GO:1900745)2.46761391
161renal filtration (GO:0097205)2.44905278
162acrosome reaction (GO:0007340)2.44536781
163adhesion of symbiont to host (GO:0044406)2.44472104
164establishment of monopolar cell polarity (GO:0061162)2.44443096
165establishment or maintenance of monopolar cell polarity (GO:0061339)2.44443096
166phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.44136498
167sphingoid metabolic process (GO:0046519)2.43165984
168O-glycan processing (GO:0016266)2.43074521
169multicellular organism reproduction (GO:0032504)2.41943356
170behavioral response to nicotine (GO:0035095)2.41354583
171eye photoreceptor cell development (GO:0042462)2.38678133
172regulation of action potential (GO:0098900)2.37473063
173positive regulation of digestive system process (GO:0060456)2.37345509
174establishment of protein localization to Golgi (GO:0072600)2.35150076
175neurotransmitter biosynthetic process (GO:0042136)2.34695298
176phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.34280709
177cAMP catabolic process (GO:0006198)2.33988804
178protein K11-linked deubiquitination (GO:0035871)2.33918015
179establishment of planar polarity (GO:0001736)2.32431988
180establishment of tissue polarity (GO:0007164)2.32431988
181microtubule-based movement (GO:0007018)2.32223260
182glutathione derivative metabolic process (GO:1901685)2.29283689
183glutathione derivative biosynthetic process (GO:1901687)2.29283689
184L-fucose metabolic process (GO:0042354)2.28323304
185L-fucose catabolic process (GO:0042355)2.28323304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.98259205
2GATA1_22025678_ChIP-Seq_K562_Human4.44197685
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.75578513
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09027731
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.08344300
6VDR_22108803_ChIP-Seq_LS180_Human2.93698488
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.71237078
8ZNF274_21170338_ChIP-Seq_K562_Hela2.70023237
9GBX2_23144817_ChIP-Seq_PC3_Human2.58415667
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53251250
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47940369
12CLOCK_20551151_ChIP-Seq_293T_Human2.45307920
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.36576909
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.32745844
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31450295
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25271371
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13060755
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11783218
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09589030
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.09249199
21SOX2_20726797_ChIP-Seq_SW620_Human2.05332826
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03129332
23ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03060417
24TAF15_26573619_Chip-Seq_HEK293_Human2.02761882
25AR_21572438_ChIP-Seq_LNCaP_Human1.96635175
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92411664
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89346531
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.87361783
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87347947
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.87197259
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86364704
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86330697
33SMAD4_21799915_ChIP-Seq_A2780_Human1.83083192
34FUS_26573619_Chip-Seq_HEK293_Human1.80508971
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79972441
36* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76858772
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75559138
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.75421341
39* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.75076480
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.72619427
41AHR_22903824_ChIP-Seq_MCF-7_Human1.67564345
42P300_19829295_ChIP-Seq_ESCs_Human1.67491225
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66819304
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64516266
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.63826066
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60234999
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58982470
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56270261
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54938844
50ER_23166858_ChIP-Seq_MCF-7_Human1.54783068
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54691777
52STAT3_23295773_ChIP-Seq_U87_Human1.54392922
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53994008
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53336014
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51947001
56* TCF4_23295773_ChIP-Seq_U87_Human1.50778687
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.50393830
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.50145591
59AR_25329375_ChIP-Seq_VCAP_Human1.49904245
60* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48225742
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46593422
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46083411
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45335288
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45265500
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.45066713
66CJUN_26792858_Chip-Seq_BT549_Human1.42860021
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42150796
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.38537587
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.37689879
70* CBP_20019798_ChIP-Seq_JUKART_Human1.37070194
71* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37070194
72EWS_26573619_Chip-Seq_HEK293_Human1.36397461
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35533328
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.35509541
75GATA4_25053715_ChIP-Seq_YYC3_Human1.34251584
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33190437
77* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32355673
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32296770
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.32277533
80DROSHA_22980978_ChIP-Seq_HELA_Human1.30762437
81TCF4_22108803_ChIP-Seq_LS180_Human1.29935021
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29927422
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.29285203
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29155108
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28451744
86RXR_22108803_ChIP-Seq_LS180_Human1.27420824
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27101679
88RACK7_27058665_Chip-Seq_MCF-7_Human1.27081593
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.26606517
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.26064339
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24949659
92CDX2_22108803_ChIP-Seq_LS180_Human1.24062438
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23758773
94* TBX20_22328084_ChIP-Seq_HEART_Mouse1.23732205
95* TBX20_22080862_ChIP-Seq_HEART_Mouse1.23732205
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22234116
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.21681485
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21032347
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20653100
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20061337
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18874251
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17841243
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17584679
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.17380060
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17357569
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17357569
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17146607
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17146607
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.17109623
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16750942
111FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15887698
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.15841761
113AR_20517297_ChIP-Seq_VCAP_Human1.15692106
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13136800
115P300_18555785_Chip-Seq_ESCs_Mouse1.12913948
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.12636228
117RUNX1_27514584_Chip-Seq_MCF-7_Human1.12187310
118P53_22387025_ChIP-Seq_ESCs_Mouse1.11949693
119* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11921481
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10050872
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09190039
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08768771
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.08642793
124BCAT_22108803_ChIP-Seq_LS180_Human1.08612000
125TP53_18474530_ChIP-ChIP_U2OS_Human1.08609492
126* SOX2_19829295_ChIP-Seq_ESCs_Human1.07268441
127* NANOG_19829295_ChIP-Seq_ESCs_Human1.07268441
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06544311
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06032014
130NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05872046
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05872046
132TP53_16413492_ChIP-PET_HCT116_Human1.05861900
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05757027
134* FOXA1_25329375_ChIP-Seq_VCAP_Human1.05742230
135* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05742230
136* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05727010
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05584552
138EED_16625203_ChIP-ChIP_MESCs_Mouse1.04115554
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03778513
140ETV1_20927104_ChIP-Seq_GIST48_Human1.02232493
141EGR1_19032775_ChIP-ChIP_M12_Human1.01202595
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99606159
143CMYC_18555785_Chip-Seq_ESCs_Mouse0.99584481
144FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99508671
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98982802
146SOX2_18555785_Chip-Seq_ESCs_Mouse0.98936288
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.98851903
148NCOR_22424771_ChIP-Seq_293T_Human0.97035366
149KLF5_25053715_ChIP-Seq_YYC3_Human0.96978267
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96924118
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.96606934
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96102880
153* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95734595
154IGF1R_20145208_ChIP-Seq_DFB_Human0.95370560
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94872484
156* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94778141
157SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94603804
158LXR_22292898_ChIP-Seq_THP-1_Human0.92082550
159EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91648280
160RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91648280
161TP63_23658742_ChIP-Seq_EP156T_Human0.91036931
162JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90952475
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90162954
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88326268
165Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88240890
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.87460821
167HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85562471
168GATA6_25053715_ChIP-Seq_YYC3_Human0.85462290
169* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83796716
170CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83327058
171HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81812805
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81534695
173JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80164036
174ISL1_27105846_Chip-Seq_CPCs_Mouse0.80072186
175SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79430008
176EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78530164
177ELK3_25401928_ChIP-Seq_HUVEC_Human0.78343192
178ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77838441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog5.00464720
2MP0001958_emphysema4.44346322
3MP0002138_abnormal_hepatobiliary_system4.07482774
4MP0002132_abnormal_respiratory_system3.88481318
5MP0010368_abnormal_lymphatic_system3.74998109
6MP0002822_catalepsy3.36383774
7MP0001177_atelectasis2.95513979
8MP0000383_abnormal_hair_follicle2.90233843
9MP0001879_abnormal_lymphatic_vessel2.88230360
10MP0002277_abnormal_respiratory_mucosa2.87854494
11MP0002736_abnormal_nociception_after2.83038314
12MP0005171_absent_coat_pigmentation2.81678285
13MP0005275_abnormal_skin_tensile2.77655491
14MP0010678_abnormal_skin_adnexa2.76834023
15MP0003300_gastrointestinal_ulcer2.70935843
16MP0005388_respiratory_system_phenotype2.65436234
17MP0002133_abnormal_respiratory_system2.65436234
18MP0001968_abnormal_touch/_nociception2.65254474
19MP0008438_abnormal_cutaneous_collagen2.60652093
20MP0005408_hypopigmentation2.52592266
21MP0005167_abnormal_blood-brain_barrier2.46335174
22MP0010386_abnormal_urinary_bladder2.45865811
23MP0004043_abnormal_pH_regulation2.43843380
24MP0003880_abnormal_central_pattern2.38393770
25MP0004272_abnormal_basement_membrane2.28631522
26MP0001984_abnormal_olfaction2.26492044
27MP0008875_abnormal_xenobiotic_pharmacok2.24924983
28MP0010234_abnormal_vibrissa_follicle2.16762623
29MP0002876_abnormal_thyroid_physiology2.15443354
30MP0002163_abnormal_gland_morphology2.11850291
31MP0005551_abnormal_eye_electrophysiolog2.11397395
32MP0002653_abnormal_ependyma_morphology2.10146659
33MP0002295_abnormal_pulmonary_circulatio2.05691251
34MP0002098_abnormal_vibrissa_morphology2.03893278
35* MP0001756_abnormal_urination1.89857751
36* MP0009643_abnormal_urine_homeostasis1.89813574
37MP0006054_spinal_hemorrhage1.87030750
38MP0005646_abnormal_pituitary_gland1.86451753
39MP0002139_abnormal_hepatobiliary_system1.83538309
40MP0005253_abnormal_eye_physiology1.83292882
41MP0003191_abnormal_cellular_cholesterol1.73654943
42MP0003279_aneurysm1.71422781
43MP0002735_abnormal_chemical_nociception1.69951518
44MP0009780_abnormal_chondrocyte_physiolo1.68898680
45MP0004133_heterotaxia1.62799190
46MP0004885_abnormal_endolymph1.59907619
47MP0008995_early_reproductive_senescence1.59870586
48MP0003566_abnormal_cell_adhesion1.59690991
49MP0005503_abnormal_tendon_morphology1.52693831
50MP0000462_abnormal_digestive_system1.52422642
51MP0000371_diluted_coat_color1.51608233
52MP0004742_abnormal_vestibular_system1.50671278
53MP0005379_endocrine/exocrine_gland_phen1.49457388
54* MP0001765_abnormal_ion_homeostasis1.48687766
55MP0000372_irregular_coat_pigmentation1.48549341
56MP0002877_abnormal_melanocyte_morpholog1.47696538
57MP0009046_muscle_twitch1.46672877
58MP0003724_increased_susceptibility_to1.42855133
59* MP0002136_abnormal_kidney_physiology1.35073889
60MP0005332_abnormal_amino_acid1.34307363
61MP0005360_urolithiasis1.34245346
62MP0005220_abnormal_exocrine_pancreas1.32328796
63MP0003329_amyloid_beta_deposits1.31147406
64* MP0005636_abnormal_mineral_homeostasis1.30687940
65MP0002160_abnormal_reproductive_system1.29722090
66MP0008872_abnormal_physiological_respon1.27125896
67MP0000343_altered_response_to1.26862482
68MP0000631_abnormal_neuroendocrine_gland1.25239592
69MP0000427_abnormal_hair_cycle1.25053470
70MP0001486_abnormal_startle_reflex1.23700375
71MP0001502_abnormal_circadian_rhythm1.21699945
72MP0008877_abnormal_DNA_methylation1.21642603
73MP0004019_abnormal_vitamin_homeostasis1.20786838
74MP0009745_abnormal_behavioral_response1.19692038
75MP0004142_abnormal_muscle_tone1.15862398
76MP0005310_abnormal_salivary_gland1.15301642
77MP0002009_preneoplasia1.14223756
78MP0001501_abnormal_sleep_pattern1.12911069
79MP0005083_abnormal_biliary_tract1.09614729
80MP0001970_abnormal_pain_threshold1.09333025
81MP0002796_impaired_skin_barrier1.06626556
82MP0005085_abnormal_gallbladder_physiolo1.05925685
83MP0004924_abnormal_behavior1.05784967
84MP0005386_behavior/neurological_phenoty1.05784967
85MP0009697_abnormal_copulation1.05671162
86MP0003011_delayed_dark_adaptation1.02171990
87MP0001485_abnormal_pinna_reflex1.02067329
88MP0005389_reproductive_system_phenotype1.01002494
89* MP0001175_abnormal_lung_morphology1.00833549
90MP0002272_abnormal_nervous_system0.99633991
91MP0003878_abnormal_ear_physiology0.98987445
92MP0005377_hearing/vestibular/ear_phenot0.98987445
93MP0010771_integument_phenotype0.97242795
94MP0002572_abnormal_emotion/affect_behav0.96296710
95MP0002928_abnormal_bile_duct0.95881869
96MP0002734_abnormal_mechanical_nocicepti0.94024429
97MP0005595_abnormal_vascular_smooth0.93084634
98MP0003186_abnormal_redox_activity0.92667100
99MP0003638_abnormal_response/metabolism_0.92222431
100MP0000249_abnormal_blood_vessel0.91702025
101MP0002557_abnormal_social/conspecific_i0.91054800
102MP0008789_abnormal_olfactory_epithelium0.90106849
103MP0003183_abnormal_peptide_metabolism0.89880132
104MP0000647_abnormal_sebaceous_gland0.89850888
105MP0001324_abnormal_eye_pigmentation0.88944299
106MP0005058_abnormal_lysosome_morphology0.88673554
107MP0005187_abnormal_penis_morphology0.88326334
108MP0003698_abnormal_male_reproductive0.88181835
109MP0000569_abnormal_digit_pigmentation0.87572082
110MP0000026_abnormal_inner_ear0.87346428
111MP0002067_abnormal_sensory_capabilities0.86618740
112MP0001919_abnormal_reproductive_system0.84519439
113MP0001270_distended_abdomen0.83292881
114MP0000537_abnormal_urethra_morphology0.82934051
115* MP0005395_other_phenotype0.82789385
116MP0004264_abnormal_extraembryonic_tissu0.81034067
117MP0000613_abnormal_salivary_gland0.80954457
118MP0008004_abnormal_stomach_pH0.80028456
119MP0002837_dystrophic_cardiac_calcinosis0.79072300
120MP0002229_neurodegeneration0.78974732
121MP0001764_abnormal_homeostasis0.78439643
122MP0005195_abnormal_posterior_eye0.78346587
123MP0005410_abnormal_fertilization0.78207044
124MP0000566_synostosis0.76903924
125MP0003941_abnormal_skin_development0.76633980
126MP0001664_abnormal_digestion0.76414350
127MP0005164_abnormal_response_to0.75843125
128MP0000230_abnormal_systemic_arterial0.75668006
129MP0003283_abnormal_digestive_organ0.74594855
130MP0002638_abnormal_pupillary_reflex0.74482582
131MP0005023_abnormal_wound_healing0.74186168
132MP0001944_abnormal_pancreas_morphology0.73474034
133MP0003091_abnormal_cell_migration0.73243634
134MP0002089_abnormal_postnatal_growth/wei0.72716078
135MP0006276_abnormal_autonomic_nervous0.72691412
136MP0004085_abnormal_heartbeat0.72588124
137MP0002064_seizures0.72518042
138MP0000678_abnormal_parathyroid_gland0.72374814
139MP0003787_abnormal_imprinting0.72266621
140MP0006072_abnormal_retinal_apoptosis0.71933950
141MP0000538_abnormal_urinary_bladder0.71160192
142MP0002234_abnormal_pharynx_morphology0.71149768
143MP0003718_maternal_effect0.70939911
144MP0002909_abnormal_adrenal_gland0.70515203
145MP0002733_abnormal_thermal_nociception0.70199087
146MP0002060_abnormal_skin_morphology0.70095367
147MP0003195_calcinosis0.68828712
148MP0008961_abnormal_basal_metabolism0.65311859
149MP0002118_abnormal_lipid_homeostasis0.64933158
150MP0000767_abnormal_smooth_muscle0.64420779
151MP0000681_abnormal_thyroid_gland0.62223396
152MP0003705_abnormal_hypodermis_morpholog0.61828218
153MP0000534_abnormal_ureter_morphology0.61792176
154MP0004883_abnormal_blood_vessel0.60526074
155MP0000465_gastrointestinal_hemorrhage0.60412615
156* MP0002168_other_aberrant_phenotype0.60057161
157MP0005248_abnormal_Harderian_gland0.56891698
158MP0000003_abnormal_adipose_tissue0.56596352
159MP0005365_abnormal_bile_salt0.56415761
160MP0002135_abnormal_kidney_morphology0.54659109
161MP0005501_abnormal_skin_physiology0.53106708
162MP0000516_abnormal_urinary_system0.52428680
163MP0005367_renal/urinary_system_phenotyp0.52428680
164MP0001943_abnormal_respiration0.51803999
165MP0003806_abnormal_nucleotide_metabolis0.51412141
166MP0001186_pigmentation_phenotype0.51194960

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of chloride homeostasis (HP:0011422)9.38325754
2* Hyperactive renin-angiotensin system (HP:0000841)8.14871939
3* Hypokalemic alkalosis (HP:0001949)7.60063667
4* Renal salt wasting (HP:0000127)7.37391940
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.14114370
6* Hyperaldosteronism (HP:0000859)6.67857765
7Absent/shortened dynein arms (HP:0200106)6.65435370
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.65435370
9Abnormal respiratory motile cilium morphology (HP:0005938)6.48683285
10Abnormal respiratory epithelium morphology (HP:0012253)6.48683285
11Metabolic alkalosis (HP:0200114)6.37249722
12Abnormal respiratory motile cilium physiology (HP:0012261)6.31508777
13Abnormal ciliary motility (HP:0012262)6.28806143
14Spontaneous hematomas (HP:0007420)6.13450567
15Rhinitis (HP:0012384)5.89316670
16Interstitial pulmonary disease (HP:0006530)5.51611586
17* Chronic bronchitis (HP:0004469)5.04395715
18Abnormality of the right ventricle (HP:0001707)4.76017767
19Conjugated hyperbilirubinemia (HP:0002908)4.39576655
20* Hyponatremia (HP:0002902)4.30338597
21Vascular calcification (HP:0004934)4.13207810
22* Alkalosis (HP:0001948)4.08287983
23Pancreatic fibrosis (HP:0100732)4.05353846
24* Abnormality of renin-angiotensin system (HP:0000847)4.01870614
25Pancreatic cysts (HP:0001737)4.01544306
26True hermaphroditism (HP:0010459)3.98660399
27Abnormality of renal excretion (HP:0011036)3.95640349
28Ileus (HP:0002595)3.91668863
29Abnormal urine output (HP:0012590)3.78261568
30Cardiovascular calcification (HP:0011915)3.76317852
31Spinal muscular atrophy (HP:0007269)3.76280614
32Esophageal varix (HP:0002040)3.73052041
33Arterial tortuosity (HP:0005116)3.71670701
34Tubulointerstitial fibrosis (HP:0005576)3.64820450
35* Abnormality of sodium homeostasis (HP:0010931)3.61355323
36Molar tooth sign on MRI (HP:0002419)3.60964635
37Abnormality of midbrain morphology (HP:0002418)3.60964635
38Polycythemia (HP:0001901)3.60000017
39Hematochezia (HP:0002573)3.57998169
40Polyuria (HP:0000103)3.54885519
41* Hypokalemia (HP:0002900)3.54452472
42* Adrenal overactivity (HP:0002717)3.51595601
43Gout (HP:0001997)3.51456066
44Vascular tortuosity (HP:0004948)3.50112736
45Decreased central vision (HP:0007663)3.45291078
46* Hyperkalemia (HP:0002153)3.41554256
47Rectal prolapse (HP:0002035)3.39280634
48Cystic liver disease (HP:0006706)3.35920414
49* Abnormality of potassium homeostasis (HP:0011042)3.33759397
50Absent rod-and cone-mediated responses on ERG (HP:0007688)3.32393325
51Abnormality of cochlea (HP:0000375)3.31694854
52Nephronophthisis (HP:0000090)3.29147687
53Abnormality of the renal medulla (HP:0100957)3.25386545
54* Hypotension (HP:0002615)3.24962218
55Chondrocalcinosis (HP:0000934)3.23576785
56Chronic hepatic failure (HP:0100626)3.22722530
57Nasal polyposis (HP:0100582)3.07799360
58Hypothermia (HP:0002045)3.07711963
59Tubular atrophy (HP:0000092)3.06917764
60Abnormality of the nasal mucosa (HP:0000433)3.06177480
61Abnormality of Sharpey fibers (HP:0100685)3.05400844
62Osteomalacia (HP:0002749)2.91086078
63Occipital encephalocele (HP:0002085)2.87612962
64Broad ribs (HP:0000885)2.81407731
65Tachypnea (HP:0002789)2.80433223
66Male infertility (HP:0003251)2.77552746
67Lip pit (HP:0100267)2.76064953
68Hypercalciuria (HP:0002150)2.75047991
69* Dehydration (HP:0001944)2.73427398
70Abnormal drinking behavior (HP:0030082)2.72775761
71Polydipsia (HP:0001959)2.72775761
72Increased circulating renin level (HP:0000848)2.61754144
73Hydroureter (HP:0000072)2.57420683
74Furrowed tongue (HP:0000221)2.56162201
75Abnormal rod and cone electroretinograms (HP:0008323)2.55544032
76Congenital hepatic fibrosis (HP:0002612)2.52590403
77Visceral angiomatosis (HP:0100761)2.52394665
78Medial flaring of the eyebrow (HP:0010747)2.45992324
79Postaxial foot polydactyly (HP:0001830)2.42512651
80Facial shape deformation (HP:0011334)2.42339238
81Potter facies (HP:0002009)2.42339238
82Redundant skin (HP:0001582)2.42302138
83Onycholysis (HP:0001806)2.41804710
84Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41425594
85Abnormality of the renal cortex (HP:0011035)2.40893185
86Woolly hair (HP:0002224)2.38098848
87Increased corneal curvature (HP:0100692)2.37429414
88Keratoconus (HP:0000563)2.37429414
89Tetany (HP:0001281)2.34625989
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.34590950
91Hyperphosphaturia (HP:0003109)2.34313183
92Gait imbalance (HP:0002141)2.33609952
93Nephrogenic diabetes insipidus (HP:0009806)2.33552835
94Hyperventilation (HP:0002883)2.29961436
95Cone-rod dystrophy (HP:0000548)2.28108243
96Hemangiomatosis (HP:0007461)2.27267538
97Tubulointerstitial nephritis (HP:0001970)2.26908091
98Renal tubular acidosis (HP:0001947)2.26229736
99Congenital primary aphakia (HP:0007707)2.25328474
100Infertility (HP:0000789)2.25234682
101Hypomagnesemia (HP:0002917)2.22533246
102* Decreased circulating renin level (HP:0003351)2.19827638
103Conjunctival telangiectasia (HP:0000524)2.18690523
104Abnormality of urine glucose concentration (HP:0011016)2.17408616
105Glycosuria (HP:0003076)2.17408616
106Renal tubular dysfunction (HP:0000124)2.16494544
107Bony spicule pigmentary retinopathy (HP:0007737)2.15949290
108Chronic sinusitis (HP:0011109)2.12362476
109* Bronchitis (HP:0012387)2.12169457
110Genital tract atresia (HP:0001827)2.11855861
111Abnormality of macular pigmentation (HP:0008002)2.10759885
112Vaginal atresia (HP:0000148)2.09185879
113Recurrent sinusitis (HP:0011108)2.08114466
114Male pseudohermaphroditism (HP:0000037)2.04282850
115Morphological abnormality of the inner ear (HP:0011390)2.03766951
116Exocrine pancreatic insufficiency (HP:0001738)2.02522675
117Tubulointerstitial abnormality (HP:0001969)2.00202537
118Abnormal urine phosphate concentration (HP:0012599)1.97401028
119Nephrolithiasis (HP:0000787)1.96172442
120Anencephaly (HP:0002323)1.96116714
121Abnormality of purine metabolism (HP:0004352)1.94249427
122Postaxial hand polydactyly (HP:0001162)1.92739973
123Sclerocornea (HP:0000647)1.92515702
124Abolished electroretinogram (ERG) (HP:0000550)1.89051388
125Febrile seizures (HP:0002373)1.88900298
126Type II lissencephaly (HP:0007260)1.88247875
127Respiratory distress (HP:0002098)1.88238749
128Median cleft lip (HP:0000161)1.87585196
129Attenuation of retinal blood vessels (HP:0007843)1.84949270
130Recurrent otitis media (HP:0000403)1.83709423
131* Bronchiectasis (HP:0002110)1.83166847
132Increased purine levels (HP:0004368)1.82136814
133Hyperuricemia (HP:0002149)1.82136814
134Cerebral hemorrhage (HP:0001342)1.77632361
135Progressive cerebellar ataxia (HP:0002073)1.77531204
136Abnormality of magnesium homeostasis (HP:0004921)1.76840897
137Hypoplastic labia majora (HP:0000059)1.76408894
138Microcytic anemia (HP:0001935)1.75786044
139Ureteral obstruction (HP:0006000)1.75152193
140Right ventricular cardiomyopathy (HP:0011663)1.74875617
141Intestinal atresia (HP:0011100)1.74654825
142Exostoses (HP:0100777)1.74007793
143Parakeratosis (HP:0001036)1.73586268
144Long toe (HP:0010511)1.71639232
145Cavernous hemangioma (HP:0001048)1.69448865
146Retinitis pigmentosa (HP:0000510)1.67474401
147Ketoacidosis (HP:0001993)1.66393978
148Macular degeneration (HP:0000608)1.66009823
149Dysostosis multiplex (HP:0000943)1.65016286
150Bladder diverticulum (HP:0000015)1.63070207
151Widely patent fontanelles and sutures (HP:0004492)1.61890519
152Absent speech (HP:0001344)1.61442764
153Abnormal biliary tract physiology (HP:0012439)1.60272307
154Bile duct proliferation (HP:0001408)1.60272307
155Gaze-evoked nystagmus (HP:0000640)1.60184697
156Thyroid-stimulating hormone excess (HP:0002925)1.58291031
157Abnormality of the labia majora (HP:0012881)1.57529874
158Popliteal pterygium (HP:0009756)1.55857328
159* Nephropathy (HP:0000112)1.55075898
160Aneurysm (HP:0002617)1.54731447
161Preaxial hand polydactyly (HP:0001177)1.54678176
162Poor coordination (HP:0002370)1.54076829
163Hypoglycemic seizures (HP:0002173)1.53451534
164Orthostatic hypotension (HP:0001278)1.52706588
165Atrophic scars (HP:0001075)1.50360578
166Pustule (HP:0200039)1.49664412
167Urinary glycosaminoglycan excretion (HP:0003541)1.47443766
168Mucopolysacchariduria (HP:0008155)1.47443766
169Glomerulosclerosis (HP:0000096)1.42782882
170Deep venous thrombosis (HP:0002625)1.42777823
171Death in childhood (HP:0003819)1.42227108
172Hepatitis (HP:0012115)1.40733638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK29.31595421
2TIE14.85001390
3MAP3K33.20735405
4CASK2.98472959
5TGFBR22.78785017
6WNK42.65864169
7MAPK152.53480749
8ERN12.51100204
9PRKG22.34733082
10MAP3K22.27681117
11MARK12.24291876
12MAP3K92.20007888
13MUSK2.14614825
14BCR2.03376340
15TAOK31.89550524
16ADRBK21.82894607
17NME11.80256588
18EPHB21.78404122
19LRRK21.75299268
20FGFR21.65832527
21MAP4K21.61855736
22BMPR1B1.58512370
23FRK1.57236093
24RIPK11.56878225
25MST41.56161960
26MAP2K31.55995643
27TAOK11.54395326
28OXSR11.51769803
29MAP3K41.49717598
30TRIB31.49138387
31PINK11.48410364
32PAK41.48395331
33FER1.46084095
34STK101.44256481
35MAPK131.43397066
36PDGFRA1.40414213
37PNCK1.31782481
38TGFBR11.31583567
39GRK11.26288036
40WNK31.24538435
41TLK11.23680316
42FGFR41.22875831
43STK391.22674498
44EPHB11.17982222
45MAP3K111.17092596
46AKT31.16001869
47MYLK1.15688886
48EIF2AK31.14772090
49PTK61.11391059
50STK38L1.09916346
51MAPKAPK51.06998890
52TESK11.02480978
53HIPK21.01470843
54MET0.98053852
55SCYL20.96231990
56STK240.95698572
57YES10.93416348
58FGFR30.92619957
59PTK20.88092172
60TNK20.87936571
61PHKG20.87686587
62PHKG10.87686587
63MST1R0.87344364
64IRAK10.87049054
65CAMK1G0.86759770
66DAPK20.86199482
67TAOK20.84602738
68CSK0.84253737
69ERBB30.78721547
70PDGFRB0.78183707
71NTRK10.76949662
72BRSK20.76618666
73LATS10.75883070
74MAP3K10.75664285
75ZAP700.74281116
76ROCK10.72066300
77TNIK0.71106259
78PRKCH0.70047288
79PIK3CG0.69523701
80TRIM280.68777500
81PRKAA20.67498643
82EPHA20.64160868
83SGK10.62310024
84CAMKK20.59009971
85TEC0.58568923
86PASK0.57906892
87CHUK0.57184041
88MAP3K130.54270534
89DYRK20.53455781
90MAP2K70.52207282
91TYK20.52164913
92GSK3A0.52030018
93ILK0.51567170
94CAMK1D0.50644142
95EPHA30.50395788
96STK110.50289903
97RPS6KB10.49565997
98PRKCE0.49039344
99PRKD10.48674888
100KDR0.48478610
101CDK60.48117680
102EGFR0.48112152
103EPHA40.47387517
104TRPM70.45662394
105SGK4940.43646639
106SGK2230.43646639
107PLK20.43607026
108LIMK10.43354958
109ROCK20.43095906
110NUAK10.42612170
111PRKCG0.41257645
112CAMK2A0.40076545
113INSRR0.40014977
114WNK10.38763617
115TTN0.38736844
116SGK30.38265351
117ADRBK10.37374389
118BLK0.36782266
119PRKACA0.35553245
120GRK50.34999699
121ERBB20.33904501
122ABL10.33763127
123PDK20.33409322
124MAP2K20.33067780
125PRKCA0.32608361
126PDPK10.31974065
127CSNK1E0.30284759
128NTRK30.30274352
129MARK30.30253311
130CSNK1A1L0.30134042
131CSNK1G10.28358836
132PTK2B0.28216614
133PRKCD0.27767203
134CSNK1A10.26793539
135PRKD20.25278426
136DMPK0.25263924
137MAP2K10.25142458
138PRKAA10.24705786
139RET0.23661415
140GRK70.21608615
141PRKCZ0.21121819
142MAP3K120.20761156
143MAP3K70.20643029
144PRKD30.20405172
145RPS6KB20.20356509
146STK30.20237372
147MAPKAPK30.18406735
148SGK20.17212946
149JAK10.16586062
150DDR20.16434685
151PAK30.15532980
152PRKCI0.15419459
153ABL20.15270558
154MARK20.15261533
155ZAK0.14786817
156FYN0.14575953

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.05873314
2Linoleic acid metabolism_Homo sapiens_hsa005913.04984426
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.64579733
4Sulfur metabolism_Homo sapiens_hsa009202.62682022
5* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.60126710
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53673163
7Fatty acid degradation_Homo sapiens_hsa000712.41045003
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.33523504
9Tryptophan metabolism_Homo sapiens_hsa003802.23313589
10Nitrogen metabolism_Homo sapiens_hsa009102.20628723
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19114574
12Vibrio cholerae infection_Homo sapiens_hsa051102.19010758
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.10440968
14Phototransduction_Homo sapiens_hsa047441.93455696
15Circadian rhythm_Homo sapiens_hsa047101.87663675
16Collecting duct acid secretion_Homo sapiens_hsa049661.84117875
17Lysosome_Homo sapiens_hsa041421.74004452
18Ether lipid metabolism_Homo sapiens_hsa005651.70773676
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66993281
20Selenocompound metabolism_Homo sapiens_hsa004501.66184066
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59193779
22Arachidonic acid metabolism_Homo sapiens_hsa005901.58308591
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58010739
24Bile secretion_Homo sapiens_hsa049761.55944482
25ECM-receptor interaction_Homo sapiens_hsa045121.53308588
26Renin-angiotensin system_Homo sapiens_hsa046141.49899348
27Adherens junction_Homo sapiens_hsa045201.45671296
28Histidine metabolism_Homo sapiens_hsa003401.44276934
29ABC transporters_Homo sapiens_hsa020101.43679022
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42052791
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.35762425
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34880010
33Tight junction_Homo sapiens_hsa045301.34375672
34Gastric acid secretion_Homo sapiens_hsa049711.31363506
35Butanoate metabolism_Homo sapiens_hsa006501.30602827
36* Taste transduction_Homo sapiens_hsa047421.30280329
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30176144
38Focal adhesion_Homo sapiens_hsa045101.25443325
39Basal transcription factors_Homo sapiens_hsa030221.23974701
40beta-Alanine metabolism_Homo sapiens_hsa004101.23616133
41Chemical carcinogenesis_Homo sapiens_hsa052041.22746923
42Nicotine addiction_Homo sapiens_hsa050331.20301736
43Caffeine metabolism_Homo sapiens_hsa002321.19687890
44Huntingtons disease_Homo sapiens_hsa050161.16568537
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.15805615
46Renin secretion_Homo sapiens_hsa049241.15631714
47Fatty acid elongation_Homo sapiens_hsa000621.14511746
48Glutamatergic synapse_Homo sapiens_hsa047241.14471446
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07803851
50Fatty acid metabolism_Homo sapiens_hsa012121.06569095
51Propanoate metabolism_Homo sapiens_hsa006401.06561023
52Peroxisome_Homo sapiens_hsa041461.05719634
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05561203
54Phenylalanine metabolism_Homo sapiens_hsa003601.02767638
55Olfactory transduction_Homo sapiens_hsa047401.02694248
56Oxidative phosphorylation_Homo sapiens_hsa001900.99701442
57Retinol metabolism_Homo sapiens_hsa008300.99298498
58Serotonergic synapse_Homo sapiens_hsa047260.97985663
59Thyroid hormone synthesis_Homo sapiens_hsa049180.96469620
60Other glycan degradation_Homo sapiens_hsa005110.96221633
61Glycerolipid metabolism_Homo sapiens_hsa005610.94404135
62Arginine and proline metabolism_Homo sapiens_hsa003300.94088507
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92748804
64Morphine addiction_Homo sapiens_hsa050320.91831765
65Pancreatic secretion_Homo sapiens_hsa049720.91521216
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91333158
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89539985
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89179117
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88892350
70Pyruvate metabolism_Homo sapiens_hsa006200.87344883
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.85590280
72Glutathione metabolism_Homo sapiens_hsa004800.84382868
73Circadian entrainment_Homo sapiens_hsa047130.84201739
74Salivary secretion_Homo sapiens_hsa049700.84000467
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83580624
76Tyrosine metabolism_Homo sapiens_hsa003500.82570938
77Insulin secretion_Homo sapiens_hsa049110.81933587
78Regulation of autophagy_Homo sapiens_hsa041400.81364839
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.79836318
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79736254
81Ovarian steroidogenesis_Homo sapiens_hsa049130.75706718
82Protein digestion and absorption_Homo sapiens_hsa049740.75687457
83Cardiac muscle contraction_Homo sapiens_hsa042600.74995002
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.74842509
85Phagosome_Homo sapiens_hsa041450.74674069
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74446036
87Bladder cancer_Homo sapiens_hsa052190.71940752
88PPAR signaling pathway_Homo sapiens_hsa033200.69377295
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68995384
90Hippo signaling pathway_Homo sapiens_hsa043900.68551133
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67387953
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65041297
93Proteoglycans in cancer_Homo sapiens_hsa052050.64820830
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64206471
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63639176
96Rap1 signaling pathway_Homo sapiens_hsa040150.63090516
97Vitamin digestion and absorption_Homo sapiens_hsa049770.62120464
98Amoebiasis_Homo sapiens_hsa051460.61282288
99Amphetamine addiction_Homo sapiens_hsa050310.61133369
100Protein export_Homo sapiens_hsa030600.60065734
101Dopaminergic synapse_Homo sapiens_hsa047280.59947480
102Calcium signaling pathway_Homo sapiens_hsa040200.59550004
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58046256
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.57864201
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56549909
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55556427
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55507543
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53992988
109Complement and coagulation cascades_Homo sapiens_hsa046100.53825588
110Platelet activation_Homo sapiens_hsa046110.53667907
111GABAergic synapse_Homo sapiens_hsa047270.53263310
112Rheumatoid arthritis_Homo sapiens_hsa053230.52503677
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.51717255
114Cocaine addiction_Homo sapiens_hsa050300.51202838
115Fatty acid biosynthesis_Homo sapiens_hsa000610.50229052
116Axon guidance_Homo sapiens_hsa043600.48295842
117Endocytosis_Homo sapiens_hsa041440.48162545
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48049329
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.47828290
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46620576
121Small cell lung cancer_Homo sapiens_hsa052220.46518894
122Metabolic pathways_Homo sapiens_hsa011000.43170874
123Hepatitis C_Homo sapiens_hsa051600.42998146
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42950322
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.42679522
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40632103
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.40501082
128Starch and sucrose metabolism_Homo sapiens_hsa005000.39966329
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39796756
130Insulin resistance_Homo sapiens_hsa049310.39746175
131Long-term depression_Homo sapiens_hsa047300.39602353
132Sphingolipid metabolism_Homo sapiens_hsa006000.36727723
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36106144
134cAMP signaling pathway_Homo sapiens_hsa040240.35399114
135Alzheimers disease_Homo sapiens_hsa050100.34968878
136Oxytocin signaling pathway_Homo sapiens_hsa049210.34353298
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34192457
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30904627
139Lysine degradation_Homo sapiens_hsa003100.30807949
140Renal cell carcinoma_Homo sapiens_hsa052110.30665972
141Asthma_Homo sapiens_hsa053100.30625517
142Dorso-ventral axis formation_Homo sapiens_hsa043200.30161625
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29550106
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29255954
145Synaptic vesicle cycle_Homo sapiens_hsa047210.28947797
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28746074
147Endometrial cancer_Homo sapiens_hsa052130.28548009

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