SCO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)4.77465579
2regulation of posttranscriptional gene silencing (GO:0060147)4.77465579
3regulation of gene silencing by miRNA (GO:0060964)4.77465579
4DNA replication checkpoint (GO:0000076)4.41642512
5ribosomal small subunit biogenesis (GO:0042274)4.15657937
6DNA strand elongation involved in DNA replication (GO:0006271)4.09471840
7nuclear pore organization (GO:0006999)4.07676556
8nuclear pore complex assembly (GO:0051292)4.06617891
9regulation of mitochondrial translation (GO:0070129)4.06165122
10DNA strand elongation (GO:0022616)3.98074486
11protein localization to kinetochore (GO:0034501)3.82342671
12DNA unwinding involved in DNA replication (GO:0006268)3.81439732
13ribosomal small subunit assembly (GO:0000028)3.73839192
14mitochondrial RNA metabolic process (GO:0000959)3.73699313
15protein localization to chromosome, centromeric region (GO:0071459)3.59717976
16nucleobase biosynthetic process (GO:0046112)3.57827974
17establishment of integrated proviral latency (GO:0075713)3.52700773
18termination of RNA polymerase III transcription (GO:0006386)3.49170189
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.49170189
20heterochromatin organization (GO:0070828)3.46697623
21DNA replication-dependent nucleosome assembly (GO:0006335)3.46496888
22DNA replication-dependent nucleosome organization (GO:0034723)3.46496888
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.44786195
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44786195
25folic acid-containing compound biosynthetic process (GO:0009396)3.41957399
26rRNA modification (GO:0000154)3.38720593
27mitotic sister chromatid cohesion (GO:0007064)3.36602757
28DNA deamination (GO:0045006)3.33308973
29regulation of translational fidelity (GO:0006450)3.33265326
30regulation of activation of Janus kinase activity (GO:0010533)3.32623211
31IMP biosynthetic process (GO:0006188)3.28770011
32regulation of translational termination (GO:0006449)3.25292055
33rRNA methylation (GO:0031167)3.25036292
34ncRNA catabolic process (GO:0034661)3.23975336
35proteasome assembly (GO:0043248)3.23363356
36deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.23204794
37maturation of SSU-rRNA (GO:0030490)3.22272921
38kinetochore assembly (GO:0051382)3.21303864
39protein complex localization (GO:0031503)3.19944209
40pore complex assembly (GO:0046931)3.19675112
41ribosome assembly (GO:0042255)3.17859908
42mitotic sister chromatid segregation (GO:0000070)3.17478504
43female gonad development (GO:0008585)3.17358497
44purine nucleobase biosynthetic process (GO:0009113)3.16957722
45regulation of helicase activity (GO:0051095)3.16721818
46microtubule depolymerization (GO:0007019)3.16581747
47transcription from mitochondrial promoter (GO:0006390)3.15852503
48DNA duplex unwinding (GO:0032508)3.15583101
49DNA geometric change (GO:0032392)3.15514227
50ribosomal large subunit biogenesis (GO:0042273)3.15272459
51pre-miRNA processing (GO:0031054)3.14706758
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14190334
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14190334
54histone exchange (GO:0043486)3.13568034
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12994857
56DNA damage response, detection of DNA damage (GO:0042769)3.12670218
57mesenchymal cell differentiation involved in renal system development (GO:2001012)3.10214522
58mesenchymal cell differentiation involved in kidney development (GO:0072161)3.10214522
59kinetochore organization (GO:0051383)3.06698318
60reciprocal DNA recombination (GO:0035825)3.01135720
61reciprocal meiotic recombination (GO:0007131)3.01135720
62superoxide anion generation (GO:0042554)3.01132543
63termination of RNA polymerase I transcription (GO:0006363)2.99797108
64chromatin assembly (GO:0031497)2.99626089
65mitotic metaphase plate congression (GO:0007080)2.99118725
66formation of translation preinitiation complex (GO:0001731)2.98330563
67DNA ligation (GO:0006266)2.95145384
68telomere maintenance via semi-conservative replication (GO:0032201)2.95029025
69L-serine metabolic process (GO:0006563)2.93977462
70regulation of DNA endoreduplication (GO:0032875)2.93961987
71ribonucleoprotein complex biogenesis (GO:0022613)2.93592194
72transcription elongation from RNA polymerase I promoter (GO:0006362)2.93260278
73tetrahydrofolate metabolic process (GO:0046653)2.92888537
74peptidyl-histidine modification (GO:0018202)2.92434131
75IMP metabolic process (GO:0046040)2.91858194
76DNA replication-independent nucleosome assembly (GO:0006336)2.91030345
77DNA replication-independent nucleosome organization (GO:0034724)2.91030345
78negative regulation of DNA-dependent DNA replication (GO:2000104)2.90198421
79regulation of centrosome cycle (GO:0046605)2.89895873
80regulation of timing of cell differentiation (GO:0048505)2.89809474
81non-recombinational repair (GO:0000726)2.89636297
82double-strand break repair via nonhomologous end joining (GO:0006303)2.89636297
83rRNA catabolic process (GO:0016075)2.89577456
84tRNA methylation (GO:0030488)2.89556975
85telomere maintenance via telomerase (GO:0007004)2.87986372
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86960997
87regulation of centriole replication (GO:0046599)2.86543346
88synapsis (GO:0007129)2.86313913
89regulation of nuclear cell cycle DNA replication (GO:0033262)2.84497538
90response to pheromone (GO:0019236)2.83946056
91CENP-A containing nucleosome assembly (GO:0034080)2.83943459
92tRNA modification (GO:0006400)2.83546593
93histone-serine phosphorylation (GO:0035404)2.82549265
94cellular protein complex localization (GO:0034629)2.82024436
95nucleotide-excision repair, DNA gap filling (GO:0006297)2.81919027
96chromatin remodeling at centromere (GO:0031055)2.81887386
97negative regulation of mRNA processing (GO:0050686)2.81808484
98water-soluble vitamin biosynthetic process (GO:0042364)2.81124926
99transcription from RNA polymerase I promoter (GO:0006360)2.80175550
100chromatin assembly or disassembly (GO:0006333)2.79708612
101protein K6-linked ubiquitination (GO:0085020)2.79679764
102regulation of mitotic spindle checkpoint (GO:1903504)2.79674315
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79674315
104DNA replication initiation (GO:0006270)2.78975107
105sister chromatid segregation (GO:0000819)2.78517652
106negative regulation of RNA splicing (GO:0033119)2.77521389
107histone H2B ubiquitination (GO:0033523)2.76758970
108cell fate commitment involved in formation of primary germ layer (GO:0060795)2.75880514
109RNA-dependent DNA replication (GO:0006278)2.74787866
110pseudouridine synthesis (GO:0001522)2.74741974
111ncRNA metabolic process (GO:0034660)2.73793989
112telomere maintenance via telomere lengthening (GO:0010833)2.72952420
113folic acid metabolic process (GO:0046655)2.72077922
114regulation of development, heterochronic (GO:0040034)2.71941097
115somatic recombination of immunoglobulin gene segments (GO:0016447)2.71856171
116RNA methylation (GO:0001510)2.71579403
117glycine metabolic process (GO:0006544)2.71574054
118adenosine metabolic process (GO:0046085)2.71227010
119lysine catabolic process (GO:0006554)2.71226084
120lysine metabolic process (GO:0006553)2.71226084
121meiotic chromosome segregation (GO:0045132)2.70694939
122RNA capping (GO:0036260)2.66684131
1237-methylguanosine RNA capping (GO:0009452)2.66684131
124viral transcription (GO:0019083)2.65376672
125positive regulation of cell fate commitment (GO:0010455)2.65155181
1267-methylguanosine mRNA capping (GO:0006370)2.63393245
127rRNA processing (GO:0006364)2.61980692
128GPI anchor biosynthetic process (GO:0006506)2.60884047
129translational termination (GO:0006415)2.60376651
130keratinocyte development (GO:0003334)2.59814657
131tRNA processing (GO:0008033)2.59646811
132DNA catabolic process, exonucleolytic (GO:0000738)2.58517326
133limb bud formation (GO:0060174)2.58329647
134positive regulation of defense response to virus by host (GO:0002230)2.56388088
135rRNA metabolic process (GO:0016072)2.56377756
136pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.55839834
137transcription initiation from RNA polymerase I promoter (GO:0006361)2.54734660
138telomere maintenance via recombination (GO:0000722)2.54240893
139viral mRNA export from host cell nucleus (GO:0046784)2.53726658
140spliceosomal snRNP assembly (GO:0000387)2.51638147
141spliceosomal complex assembly (GO:0000245)2.51050523
142regulation of double-strand break repair via homologous recombination (GO:0010569)2.50229134
143DNA topological change (GO:0006265)2.49846576
144amino sugar catabolic process (GO:0046348)2.49038533
145regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.48510957
146positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.48352583
147transcription-coupled nucleotide-excision repair (GO:0006283)2.42353878
148regulation of pigment cell differentiation (GO:0050932)2.41700623
149preassembly of GPI anchor in ER membrane (GO:0016254)2.41183181
150polyol transport (GO:0015791)2.40326435
151maturation of 5.8S rRNA (GO:0000460)2.39768496
152RNA modification (GO:0009451)2.38031901
153negative regulation of transcription by competitive promoter binding (GO:0010944)2.37289581
154ncRNA processing (GO:0034470)2.36966646
155polyketide metabolic process (GO:0030638)2.36860800
156doxorubicin metabolic process (GO:0044598)2.36860800
157daunorubicin metabolic process (GO:0044597)2.36860800
158deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.36521373
159developmental pigmentation (GO:0048066)2.36186349
160deoxyribonucleotide biosynthetic process (GO:0009263)2.35628945
161cell differentiation involved in metanephros development (GO:0072202)2.35155922
162ribosome biogenesis (GO:0042254)2.34788661
163mitotic recombination (GO:0006312)2.33015001
164cellular component biogenesis (GO:0044085)2.32819840
165sympathetic nervous system development (GO:0048485)2.31330272
166natural killer cell activation involved in immune response (GO:0002323)2.30982797
167intra-S DNA damage checkpoint (GO:0031573)2.30901958
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.30471170
169response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.28945377
170GPI anchor metabolic process (GO:0006505)2.28315693
171response to folic acid (GO:0051593)2.27974686
172lymphoid progenitor cell differentiation (GO:0002320)2.27390996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.62084869
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.57676550
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.76920237
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.61461139
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05794263
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.01864506
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00707144
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97274784
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.62040604
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.54980944
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.54876545
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.53913472
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.50569670
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.49046708
15XRN2_22483619_ChIP-Seq_HELA_Human2.42755917
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.36169353
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30969471
18IRF1_19129219_ChIP-ChIP_H3396_Human2.28980300
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28432949
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26992136
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26135236
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24972728
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20135078
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.19972571
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16221140
26* GABP_17652178_ChIP-ChIP_JURKAT_Human2.14167561
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.13996278
28DCP1A_22483619_ChIP-Seq_HELA_Human2.10570670
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09511998
30NFE2_27457419_Chip-Seq_LIVER_Mouse2.05256008
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02671837
32SUZ12_27294783_Chip-Seq_NPCs_Mouse2.02486724
33* GABP_19822575_ChIP-Seq_HepG2_Human2.01942935
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00243747
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99548873
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99069691
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93734100
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91484544
39ELK1_19687146_ChIP-ChIP_HELA_Human1.84997871
40ZNF274_21170338_ChIP-Seq_K562_Hela1.84231977
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79303647
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79040603
43* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.75171017
44AR_21909140_ChIP-Seq_LNCAP_Human1.74116836
45KDM5A_27292631_Chip-Seq_BREAST_Human1.73353145
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69914521
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.69392493
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68541021
49MYC_18940864_ChIP-ChIP_HL60_Human1.67320826
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65883291
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65257056
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.65229937
53TAF15_26573619_Chip-Seq_HEK293_Human1.64913082
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64124386
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.63544651
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61862963
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60865758
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60560152
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.55429181
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.55278422
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54091676
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53684256
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53391800
64EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.52926670
65P300_18555785_Chip-Seq_ESCs_Mouse1.49685016
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49546271
67NMYC_18555785_Chip-Seq_ESCs_Mouse1.49149551
68* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49050699
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.46233800
70RUNX1_27457419_Chip-Seq_LIVER_Mouse1.45145110
71VDR_22108803_ChIP-Seq_LS180_Human1.43320057
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41301420
73RNF2_27304074_Chip-Seq_NSC_Mouse1.40642001
74VDR_23849224_ChIP-Seq_CD4+_Human1.40498158
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.39925622
76ZFX_18555785_Chip-Seq_ESCs_Mouse1.39844763
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.39092761
78CIITA_25753668_ChIP-Seq_RAJI_Human1.39014026
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.38986627
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38565349
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36888258
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35569061
83* FOXP3_21729870_ChIP-Seq_TREG_Human1.35437487
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.33417261
85KLF4_18555785_Chip-Seq_ESCs_Mouse1.33068836
86P53_22387025_ChIP-Seq_ESCs_Mouse1.30774106
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30276206
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30276206
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30276206
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30234039
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.28933706
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.28537213
93* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26134848
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25211239
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.24885994
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.24755325
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.24528009
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23721357
99TTF2_22483619_ChIP-Seq_HELA_Human1.23698260
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.23021048
101EWS_26573619_Chip-Seq_HEK293_Human1.21989653
102SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21850882
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21387618
104GBX2_23144817_ChIP-Seq_PC3_Human1.20160904
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19955758
106BP1_19119308_ChIP-ChIP_Hs578T_Human1.19613140
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19516589
108* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17508735
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17084183
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.16734340
111PU1_27457419_Chip-Seq_LIVER_Mouse1.13685545
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13613729
113FUS_26573619_Chip-Seq_HEK293_Human1.13401799
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13256961
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.11954859
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11470657
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10429531
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09495070
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09169066
120IGF1R_20145208_ChIP-Seq_DFB_Human1.07233333
121SOX2_16153702_ChIP-ChIP_HESCs_Human1.07093294
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07012788
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06556157
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05986297
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05799142
126CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03387277
127KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01077798
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00476194
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00402404
130NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99253023
131EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98471964
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.97425899
133* ELK1_22589737_ChIP-Seq_MCF10A_Human0.97158807
134SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95620901
135TFEB_21752829_ChIP-Seq_HELA_Human0.95231054
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.94794866
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94592384
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91928506
139MYC_22102868_ChIP-Seq_BL_Human0.90066143
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89412403
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87071280
142* CHD1_26751641_Chip-Seq_LNCaP_Human0.82965975
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82526303
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78950285
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.78608149
146TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75838843
147* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75320621
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74575811
149CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73289404
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71899368
151* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71504045
152FOXP1_21924763_ChIP-Seq_HESCs_Human0.69875963
153TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69691175
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68510552
155POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.65364393
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65338390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.18279226
2MP0006292_abnormal_olfactory_placode4.03897352
3MP0000566_synostosis3.91274304
4MP0009379_abnormal_foot_pigmentation3.48014414
5MP0002102_abnormal_ear_morphology3.35040251
6MP0001188_hyperpigmentation3.27646603
7MP0005409_darkened_coat_color2.87006895
8MP0002277_abnormal_respiratory_mucosa2.85146037
9MP0008057_abnormal_DNA_replication2.75222784
10MP0003941_abnormal_skin_development2.71936213
11MP0003646_muscle_fatigue2.71758101
12MP0004381_abnormal_hair_follicle2.61177719
13MP0008058_abnormal_DNA_repair2.57816204
14MP0005379_endocrine/exocrine_gland_phen2.46646373
15MP0003718_maternal_effect2.42653164
16MP0002163_abnormal_gland_morphology2.40670948
17MP0003693_abnormal_embryo_hatching2.23245789
18MP0003786_premature_aging2.03749419
19MP0008877_abnormal_DNA_methylation1.97720698
20MP0005171_absent_coat_pigmentation1.91572116
21MP0003724_increased_susceptibility_to1.91138211
22MP0010094_abnormal_chromosome_stability1.91060835
23MP0001661_extended_life_span1.90835276
24MP0000015_abnormal_ear_pigmentation1.86947847
25MP0005451_abnormal_body_composition1.79496278
26MP0004233_abnormal_muscle_weight1.79127860
27MP0003111_abnormal_nucleus_morphology1.75499355
28MP0001730_embryonic_growth_arrest1.71825439
29MP0000350_abnormal_cell_proliferation1.71460595
30MP0008932_abnormal_embryonic_tissue1.70347787
31MP0005174_abnormal_tail_pigmentation1.69830067
32MP0002249_abnormal_larynx_morphology1.69747455
33MP0002254_reproductive_system_inflammat1.67393009
34MP0002638_abnormal_pupillary_reflex1.64803004
35MP0001672_abnormal_embryogenesis/_devel1.64254129
36MP0005380_embryogenesis_phenotype1.64254129
37MP0004147_increased_porphyrin_level1.63301088
38MP0009672_abnormal_birth_weight1.60645808
39MP0000049_abnormal_middle_ear1.59295488
40MP0010307_abnormal_tumor_latency1.59136265
41MP0008260_abnormal_autophagy1.56569049
42MP0001835_abnormal_antigen_presentation1.54407977
43MP0009785_altered_susceptibility_to1.54315163
44MP0005075_abnormal_melanosome_morpholog1.48557533
45MP0003984_embryonic_growth_retardation1.48127831
46MP0004185_abnormal_adipocyte_glucose1.47892219
47MP0010352_gastrointestinal_tract_polyps1.47055485
48MP0001697_abnormal_embryo_size1.46944527
49MP0002084_abnormal_developmental_patter1.46859050
50MP0002148_abnormal_hypersensitivity_rea1.45523818
51MP0002938_white_spotting1.44940265
52MP0000372_irregular_coat_pigmentation1.44836190
53MP0002088_abnormal_embryonic_growth/wei1.42821386
54MP0008995_early_reproductive_senescence1.41997909
55MP0006035_abnormal_mitochondrial_morpho1.41236732
56MP0004197_abnormal_fetal_growth/weight/1.40692098
57MP0003806_abnormal_nucleotide_metabolis1.37574871
58MP0003315_abnormal_perineum_morphology1.32917247
59MP0003077_abnormal_cell_cycle1.31107471
60MP0000613_abnormal_salivary_gland1.31069951
61MP0003119_abnormal_digestive_system1.30175635
62MP0004133_heterotaxia1.29383437
63MP0002085_abnormal_embryonic_tissue1.29073946
64MP0000537_abnormal_urethra_morphology1.26761570
65MP0001986_abnormal_taste_sensitivity1.26462173
66MP0002751_abnormal_autonomic_nervous1.25896773
67MP0009697_abnormal_copulation1.24891844
68MP0003938_abnormal_ear_development1.24563097
69MP0004782_abnormal_surfactant_physiolog1.24021725
70MP0000026_abnormal_inner_ear1.22865413
71MP0003937_abnormal_limbs/digits/tail_de1.22698068
72MP0003828_pulmonary_edema1.21726446
73MP0003890_abnormal_embryonic-extraembry1.21432636
74MP0004742_abnormal_vestibular_system1.21001645
75MP0002080_prenatal_lethality1.20925070
76MP0002132_abnormal_respiratory_system1.19509472
77MP0004043_abnormal_pH_regulation1.18227788
78MP0001286_abnormal_eye_development1.12345743
79MP0000313_abnormal_cell_death1.11585308
80MP0002697_abnormal_eye_size1.11086036
81MP0000490_abnormal_crypts_of1.10051026
82MP0006072_abnormal_retinal_apoptosis1.09094929
83MP0005671_abnormal_response_to1.07756918
84MP0002210_abnormal_sex_determination1.07532222
85MP0009053_abnormal_anal_canal1.06701839
86MP0002095_abnormal_skin_pigmentation1.06478343
87MP0002009_preneoplasia1.06242689
88MP0002139_abnormal_hepatobiliary_system1.05891768
89MP0005187_abnormal_penis_morphology1.04750473
90MP0006036_abnormal_mitochondrial_physio1.04740708
91MP0006276_abnormal_autonomic_nervous1.04697597
92MP0000762_abnormal_tongue_morphology1.03651014
93MP0000358_abnormal_cell_content/1.01605466
94MP0002086_abnormal_extraembryonic_tissu1.00886761
95MP0002111_abnormal_tail_morphology0.97675328
96MP0000383_abnormal_hair_follicle0.97615036
97MP0002396_abnormal_hematopoietic_system0.97212933
98MP0004130_abnormal_muscle_cell0.94731171
99MP0001145_abnormal_male_reproductive0.93387878
100MP0008789_abnormal_olfactory_epithelium0.92503785
101MP0002138_abnormal_hepatobiliary_system0.91472079
102MP0005332_abnormal_amino_acid0.90773169
103MP0005645_abnormal_hypothalamus_physiol0.90567796
104MP0002837_dystrophic_cardiac_calcinosis0.89426663
105MP0005000_abnormal_immune_tolerance0.88806222
106MP0001929_abnormal_gametogenesis0.85805218
107MP0003195_calcinosis0.84003795
108MP0000470_abnormal_stomach_morphology0.83700134
109MP0002177_abnormal_outer_ear0.83618290
110MP0005025_abnormal_response_to0.83539189
111MP0001919_abnormal_reproductive_system0.82901480
112MP0003186_abnormal_redox_activity0.82440684
113MP0008007_abnormal_cellular_replicative0.82100728
114MP0004957_abnormal_blastocyst_morpholog0.81652006
115MP0001963_abnormal_hearing_physiology0.80141591
116MP0009703_decreased_birth_body0.79385136
117MP0003763_abnormal_thymus_physiology0.77767838
118MP0001485_abnormal_pinna_reflex0.77535187
119MP0000653_abnormal_sex_gland0.76923404
120MP0005266_abnormal_metabolism0.75941766
121MP0002098_abnormal_vibrissa_morphology0.73513523
122MP0002234_abnormal_pharynx_morphology0.73477910
123MP0005084_abnormal_gallbladder_morpholo0.73460005
124MP0002933_joint_inflammation0.73300067
125MP0005085_abnormal_gallbladder_physiolo0.73082493
126MP0000631_abnormal_neuroendocrine_gland0.72674479
127MP0001800_abnormal_humoral_immune0.72414506
128MP0000647_abnormal_sebaceous_gland0.72363998
129MP0001764_abnormal_homeostasis0.71848589
130MP0002723_abnormal_immune_serum0.71335421
131MP0010030_abnormal_orbit_morphology0.71320041
132MP0005253_abnormal_eye_physiology0.70432122
133MP0005387_immune_system_phenotype0.70059766
134MP0001790_abnormal_immune_system0.70059766
135MP0001905_abnormal_dopamine_level0.69953596
136MP0000428_abnormal_craniofacial_morphol0.69817192
137MP0002452_abnormal_antigen_presenting0.69618598
138MP0004142_abnormal_muscle_tone0.69028176
139MP0001186_pigmentation_phenotype0.68131068
140MP0002019_abnormal_tumor_incidence0.68090898
141MP0004215_abnormal_myocardial_fiber0.65480588
142MP0009333_abnormal_splenocyte_physiolog0.64854740
143MP0000427_abnormal_hair_cycle0.64288639
144MP0001119_abnormal_female_reproductive0.62907665
145MP0010386_abnormal_urinary_bladder0.62859096
146MP0001346_abnormal_lacrimal_gland0.62667981
147MP0003861_abnormal_nervous_system0.61666420
148MP0009764_decreased_sensitivity_to0.61074435
149MP0005377_hearing/vestibular/ear_phenot0.60802951
150MP0003878_abnormal_ear_physiology0.60802951
151MP0001293_anophthalmia0.60512926
152MP0002233_abnormal_nose_morphology0.60132091
153MP0002160_abnormal_reproductive_system0.59828492
154MP0005389_reproductive_system_phenotype0.59752765
155MP0005395_other_phenotype0.59520636
156MP0003567_abnormal_fetal_cardiomyocyte0.59262519
157MP0010678_abnormal_skin_adnexa0.58792703
158MP0001819_abnormal_immune_cell0.58300961
159MP0005220_abnormal_exocrine_pancreas0.58023112
160MP0008875_abnormal_xenobiotic_pharmacok0.54819270
161MP0008775_abnormal_heart_ventricle0.53025394

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.90269712
2Chromsome breakage (HP:0040012)5.41800395
3Duplicated collecting system (HP:0000081)4.49335221
4Reticulocytopenia (HP:0001896)4.42967567
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.00079935
6Abnormality of alanine metabolism (HP:0010916)4.00079935
7Hyperalaninemia (HP:0003348)4.00079935
8Abnormality of the renal collecting system (HP:0004742)3.98271999
9Renal cortical cysts (HP:0000803)3.37219431
10Abnormality of the preputium (HP:0100587)3.12354355
11Patellar aplasia (HP:0006443)2.99820420
12Duplication of thumb phalanx (HP:0009942)2.97500181
13Osteomalacia (HP:0002749)2.87502486
14Microvesicular hepatic steatosis (HP:0001414)2.84883055
15Meckel diverticulum (HP:0002245)2.83211786
16Aplasia/Hypoplasia of the patella (HP:0006498)2.80240413
17Hypoplasia of the pons (HP:0012110)2.79720578
18Septo-optic dysplasia (HP:0100842)2.78618568
19Abnormality of DNA repair (HP:0003254)2.78353097
20Abnormality of serum amino acid levels (HP:0003112)2.76635675
21Abnormality of the ileum (HP:0001549)2.69790286
22Hyperglycinuria (HP:0003108)2.67260890
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.67128092
24Absent radius (HP:0003974)2.59930321
253-Methylglutaconic aciduria (HP:0003535)2.59228022
26Colon cancer (HP:0003003)2.57229821
27Type I transferrin isoform profile (HP:0003642)2.56578115
28Abnormality of the pons (HP:0007361)2.54948936
29Breast hypoplasia (HP:0003187)2.53376707
30Aplasia involving forearm bones (HP:0009822)2.51759184
31Absent forearm bone (HP:0003953)2.51759184
32Partial agenesis of the corpus callosum (HP:0001338)2.51415992
33Upper limb muscle weakness (HP:0003484)2.51123843
34Progressive muscle weakness (HP:0003323)2.50464836
35Multiple enchondromatosis (HP:0005701)2.49494851
36Abnormality of homocysteine metabolism (HP:0010919)2.45850649
37Homocystinuria (HP:0002156)2.45850649
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44636199
39Nephroblastoma (Wilms tumor) (HP:0002667)2.44372898
40Clubbing of toes (HP:0100760)2.42012332
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37880883
42Abnormality of the axillary hair (HP:0100134)2.37289628
43Abnormality of secondary sexual hair (HP:0009888)2.37289628
44Ectopic kidney (HP:0000086)2.36992471
45Abnormality of pyrimidine metabolism (HP:0004353)2.36968337
46Pendular nystagmus (HP:0012043)2.36955842
47Impulsivity (HP:0100710)2.36209110
48Abnormality of chromosome stability (HP:0003220)2.35857366
49Embryonal renal neoplasm (HP:0011794)2.31032849
50Triphalangeal thumb (HP:0001199)2.28553860
51Abnormality of serine family amino acid metabolism (HP:0010894)2.27613356
52Abnormality of glycine metabolism (HP:0010895)2.27613356
53Intestinal fistula (HP:0100819)2.27244482
54Increased hepatocellular lipid droplets (HP:0006565)2.24894181
55Horseshoe kidney (HP:0000085)2.24736889
56Facial cleft (HP:0002006)2.23347421
57Aplasia/hypoplasia of the uterus (HP:0008684)2.21971319
58Increased serum lactate (HP:0002151)2.19288376
59Renal Fanconi syndrome (HP:0001994)2.18993820
60Abnormal number of incisors (HP:0011064)2.17219627
61Absent thumb (HP:0009777)2.15807743
62Abnormality of cells of the erythroid lineage (HP:0012130)2.14429006
63Bilateral microphthalmos (HP:0007633)2.13807001
64Asplenia (HP:0001746)2.13742540
65Prostate neoplasm (HP:0100787)2.12849332
66Hyperglycinemia (HP:0002154)2.10974881
67Parakeratosis (HP:0001036)2.08631780
68Hypothermia (HP:0002045)2.08355400
69Pallor (HP:0000980)2.08229541
70Optic nerve hypoplasia (HP:0000609)2.07909498
71Abnormal number of erythroid precursors (HP:0012131)2.07682605
72Aplasia/Hypoplasia of the spleen (HP:0010451)2.04738744
73Pancreatic cysts (HP:0001737)2.04353190
74Attenuation of retinal blood vessels (HP:0007843)2.03483534
75Hypoplasia of the fovea (HP:0007750)2.03195516
76Aplasia/Hypoplasia of the fovea (HP:0008060)2.03195516
77Sloping forehead (HP:0000340)2.02928385
78Bone marrow hypocellularity (HP:0005528)2.00242450
79Congenital sensorineural hearing impairment (HP:0008527)1.99878865
80Rectovaginal fistula (HP:0000143)1.98222101
81Rectal fistula (HP:0100590)1.98222101
82Short thumb (HP:0009778)1.98141213
83Intestinal atresia (HP:0011100)1.97648951
84Thyroid-stimulating hormone excess (HP:0002925)1.96635619
85Dry hair (HP:0011359)1.95709113
86Microretrognathia (HP:0000308)1.94858086
87Aplasia/Hypoplasia involving the musculature (HP:0001460)1.93311540
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92205501
89Sex reversal (HP:0012245)1.91912271
90Abnormal sex determination (HP:0012244)1.91912271
91Aplasia cutis congenita (HP:0001057)1.91436403
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91143158
93Exertional dyspnea (HP:0002875)1.91021935
94Small intestinal stenosis (HP:0012848)1.89710553
95Duodenal stenosis (HP:0100867)1.89710553
96Macrocytic anemia (HP:0001972)1.89687354
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88960873
98Megaloblastic anemia (HP:0001889)1.88725660
99Elfin facies (HP:0004428)1.87356013
100Tubulointerstitial nephritis (HP:0001970)1.85957404
101Progressive external ophthalmoplegia (HP:0000590)1.85557507
102Abnormality of methionine metabolism (HP:0010901)1.85249309
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85075917
104Neoplasm of the adrenal cortex (HP:0100641)1.84933204
105Oligohydramnios (HP:0001562)1.84246363
106Prolonged neonatal jaundice (HP:0006579)1.84121160
107Abnormality of the labia minora (HP:0012880)1.83895618
108Recurrent pneumonia (HP:0006532)1.83714455
109Acute necrotizing encephalopathy (HP:0006965)1.83397754
110Overriding aorta (HP:0002623)1.83009511
111Neoplasm of the colon (HP:0100273)1.82839178
112Reduced antithrombin III activity (HP:0001976)1.82322987
113Increased IgM level (HP:0003496)1.81447853
114Protruding tongue (HP:0010808)1.80891634
115Squamous cell carcinoma (HP:0002860)1.80357809
116Increased CSF lactate (HP:0002490)1.77895485
117Pseudobulbar signs (HP:0002200)1.77067290
118Testicular atrophy (HP:0000029)1.76731932
119Abnormality of the septum pellucidum (HP:0007375)1.76661902
120Absent septum pellucidum (HP:0001331)1.76373492
121Abnormal protein glycosylation (HP:0012346)1.75225188
122Abnormal glycosylation (HP:0012345)1.75225188
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75225188
124Abnormal protein N-linked glycosylation (HP:0012347)1.75225188
125Selective tooth agenesis (HP:0001592)1.75031957
126Abnormality of the carotid arteries (HP:0005344)1.74626148
127Mitochondrial inheritance (HP:0001427)1.73909244
128Birth length less than 3rd percentile (HP:0003561)1.73895150
129Pancytopenia (HP:0001876)1.73599677
130Lipid accumulation in hepatocytes (HP:0006561)1.73056946
131Vaginal fistula (HP:0004320)1.72860293
132Male pseudohermaphroditism (HP:0000037)1.72756822
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72273733
134Renal agenesis (HP:0000104)1.71535252
135Optic disc pallor (HP:0000543)1.70943962
136Hypergonadotropic hypogonadism (HP:0000815)1.70875355
137Abnormality of the duodenum (HP:0002246)1.70744687
138Hypoplasia of the radius (HP:0002984)1.70656831
139Clumsiness (HP:0002312)1.69788348
140Aplasia of the musculature (HP:0100854)1.69698888
141Congenital, generalized hypertrichosis (HP:0004540)1.69091534
142Conjugated hyperbilirubinemia (HP:0002908)1.69012847
143True hermaphroditism (HP:0010459)1.68069680
144Abnormality of the renal cortex (HP:0011035)1.67700051
145Methylmalonic aciduria (HP:0012120)1.66777554
146Popliteal pterygium (HP:0009756)1.66353374
147Progressive inability to walk (HP:0002505)1.65674355
148Absent/shortened dynein arms (HP:0200106)1.65333065
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.65333065
150Overfolded helix (HP:0000396)1.65183901
151Renal tubular dysfunction (HP:0000124)1.64743632
152Neoplasm of the adrenal gland (HP:0100631)1.64546453
153Lactic acidosis (HP:0003128)1.63742318
154Anomalous pulmonary venous return (HP:0010772)1.62743577
155Cerebellar dysplasia (HP:0007033)1.62690086
156Elevated erythrocyte sedimentation rate (HP:0003565)1.62361098
157Type II lissencephaly (HP:0007260)1.61983076
158High anterior hairline (HP:0009890)1.61952712
159Cerebral edema (HP:0002181)1.61774662
160Hyperacusis (HP:0010780)1.60550664
161Poikiloderma (HP:0001029)1.60299186
162Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59901966
163Dysmetric saccades (HP:0000641)1.59357658
164Hypobetalipoproteinemia (HP:0003563)1.59125463
165Ureteral duplication (HP:0000073)1.59015096
166Renovascular hypertension (HP:0100817)1.58747890
167IgA deficiency (HP:0002720)1.58440670
168Abnormal biliary tract physiology (HP:0012439)1.57700020
169Bile duct proliferation (HP:0001408)1.57700020
170Increased nuchal translucency (HP:0010880)1.57550981
171Esophageal atresia (HP:0002032)1.55857668
172Abnormality of subcutaneous fat tissue (HP:0001001)1.55551985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.64900068
2MKNK23.53255089
3BLK3.23661449
4CASK3.06606101
5MKNK12.89785104
6SRPK12.84459336
7TNIK2.74976402
8EIF2AK22.50847852
9TLK12.33165732
10CDK122.29520171
11ZAK2.26641360
12WNK42.21507972
13EEF2K2.20075859
14NEK12.10005050
15MAP3K141.95980499
16FRK1.90261014
17PBK1.83322392
18TAF11.79351722
19IRAK31.78720973
20IRAK41.78087212
21VRK21.74097715
22BRSK21.71995719
23EIF2AK31.69760949
24NUAK11.66503456
25ADRBK21.65387404
26BUB11.63815569
27BMPR1B1.62304371
28NEK21.56418978
29NLK1.47148443
30NME21.46483381
31PDK21.45472914
32CAMK1D1.44091516
33CDK41.43510237
34GRK11.41238757
35NEK61.40666172
36YES11.36332227
37CDK191.35650455
38VRK11.35450978
39TEC1.27711635
40GRK71.27705743
41IRAK21.24914277
42PIM21.20458662
43IRAK11.17434462
44AKT31.15825471
45PLK41.13897041
46MST41.13541503
47STK391.11631160
48ALK1.05313947
49WEE11.05134403
50CAMK1G1.02162109
51TXK0.99819010
52DYRK20.98447279
53SMG10.98150150
54CDK70.96678576
55ACVR1B0.96585813
56WNK30.95914672
57CDK80.94368957
58TTK0.93696998
59IKBKB0.92388907
60CDK60.90508742
61ERBB40.89889598
62MUSK0.89692413
63PNCK0.88131542
64BRD40.87337021
65NME10.85343568
66TGFBR10.84564227
67EPHA20.83510951
68DYRK30.82574802
69BMPR20.81021163
70CHEK20.79873993
71PKN10.79311479
72EIF2AK10.75532382
73EPHA30.74331027
74STK38L0.72932510
75PLK10.72831192
76CLK10.72022889
77INSRR0.71922948
78MAPK130.71406716
79STK40.69867889
80ATR0.66621685
81EPHB20.66493241
82CDK10.66213763
83PLK30.65878810
84BRAF0.65597210
85MELK0.65494068
86STK240.65243253
87MAPK110.65043334
88MAP3K90.64953485
89CDK20.64669838
90BCR0.63377928
91AURKB0.61934330
92PINK10.59805551
93RPS6KA50.58758560
94STK30.58355869
95CSNK1E0.56927822
96OXSR10.56823967
97TNK20.56697649
98TRPM70.56479632
99LYN0.55845730
100PRKDC0.54822481
101CDK30.53662619
102WNK10.52639912
103AURKA0.52429549
104MAP3K40.51987857
105PIM10.51125173
106IKBKE0.48800130
107MAP2K20.48627117
108MAPKAPK30.47370986
109LATS20.47229681
110RPS6KB20.47099429
111CSNK2A10.46716676
112MAP2K70.45759440
113ATM0.44048865
114CSNK2A20.42617470
115BRSK10.40924001
116PIK3CG0.40510274
117JAK30.39187099
118PRKAA20.39008297
119KIT0.38813989
120CSNK1D0.38705190
121KDR0.38668393
122CSNK1A1L0.38357627
123BTK0.37047341
124PRKCE0.36739063
125OBSCN0.36145472
126CHUK0.36131082
127RPS6KA60.35264564
128CDK90.34863994
129CDC70.34666546
130MAPK140.34430857
131DYRK1A0.34078627
132ADRBK10.33862595
133FES0.33717706
134LCK0.33600831
135PIK3CA0.32140892
136CHEK10.31017743
137CSNK1G10.30851856
138TSSK60.30792941
139PRKAA10.30163825
140TESK20.30025704
141ICK0.29963034
142PRKCI0.29256619
143NEK90.29132067
144GSK3B0.28762233
145PASK0.28739741
146MAPKAPK50.28128895
147MTOR0.27899399
148MAP3K80.27796496
149PRKCQ0.26100934

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.50795057
2Selenocompound metabolism_Homo sapiens_hsa004503.35182123
3Homologous recombination_Homo sapiens_hsa034403.05462236
4Fanconi anemia pathway_Homo sapiens_hsa034603.01744058
5RNA polymerase_Homo sapiens_hsa030202.90209815
6DNA replication_Homo sapiens_hsa030302.86116157
7Mismatch repair_Homo sapiens_hsa034302.76893607
8Proteasome_Homo sapiens_hsa030502.64989288
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59446191
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34265664
11Nucleotide excision repair_Homo sapiens_hsa034202.14364283
12Pyrimidine metabolism_Homo sapiens_hsa002402.05394113
13Allograft rejection_Homo sapiens_hsa053301.95089373
14Spliceosome_Homo sapiens_hsa030401.91653952
15One carbon pool by folate_Homo sapiens_hsa006701.89276815
16Basal transcription factors_Homo sapiens_hsa030221.87930850
17Non-homologous end-joining_Homo sapiens_hsa034501.79113654
18Autoimmune thyroid disease_Homo sapiens_hsa053201.77287079
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.76356814
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72948112
21Oxidative phosphorylation_Homo sapiens_hsa001901.66825322
22Graft-versus-host disease_Homo sapiens_hsa053321.64432283
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56955421
24Base excision repair_Homo sapiens_hsa034101.53900111
25Pyruvate metabolism_Homo sapiens_hsa006201.51563160
26Protein export_Homo sapiens_hsa030601.48290282
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.40230234
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37668087
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37573552
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37563775
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37037905
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34896030
33Arachidonic acid metabolism_Homo sapiens_hsa005901.32339831
34Parkinsons disease_Homo sapiens_hsa050121.31191626
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29852658
36Propanoate metabolism_Homo sapiens_hsa006401.26793840
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26724295
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24746288
39Lysine degradation_Homo sapiens_hsa003101.24586564
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.23485424
41Systemic lupus erythematosus_Homo sapiens_hsa053221.21800991
42Vitamin B6 metabolism_Homo sapiens_hsa007501.21421835
43Nitrogen metabolism_Homo sapiens_hsa009101.20753374
44Purine metabolism_Homo sapiens_hsa002301.19085624
45Primary immunodeficiency_Homo sapiens_hsa053401.17535914
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17377140
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13701503
48RNA transport_Homo sapiens_hsa030131.10847928
49Phototransduction_Homo sapiens_hsa047441.10293268
50Huntingtons disease_Homo sapiens_hsa050161.09895534
51RNA degradation_Homo sapiens_hsa030181.08981002
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04528085
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03434161
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03115871
55Asthma_Homo sapiens_hsa053101.02863189
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99385441
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97307097
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95926734
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95132744
60Biosynthesis of amino acids_Homo sapiens_hsa012300.93890106
61Linoleic acid metabolism_Homo sapiens_hsa005910.93595004
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93207131
63Measles_Homo sapiens_hsa051620.92443368
64Steroid biosynthesis_Homo sapiens_hsa001000.91569183
65p53 signaling pathway_Homo sapiens_hsa041150.90387771
66Herpes simplex infection_Homo sapiens_hsa051680.89428059
67Butanoate metabolism_Homo sapiens_hsa006500.89385376
68Cell cycle_Homo sapiens_hsa041100.88989767
69Sulfur relay system_Homo sapiens_hsa041220.87471241
70Arginine biosynthesis_Homo sapiens_hsa002200.87289986
71Fatty acid elongation_Homo sapiens_hsa000620.85360616
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84308013
73Alzheimers disease_Homo sapiens_hsa050100.84216974
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80894442
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80716571
76Ether lipid metabolism_Homo sapiens_hsa005650.79939193
77Fatty acid degradation_Homo sapiens_hsa000710.79157853
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78846579
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.78452025
80Hematopoietic cell lineage_Homo sapiens_hsa046400.76027426
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74638092
82Fatty acid metabolism_Homo sapiens_hsa012120.70900115
83Retinol metabolism_Homo sapiens_hsa008300.70836474
84Sphingolipid metabolism_Homo sapiens_hsa006000.69709696
85Type I diabetes mellitus_Homo sapiens_hsa049400.69500504
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67653885
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.67228602
88Arginine and proline metabolism_Homo sapiens_hsa003300.65999561
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65436700
90Tyrosine metabolism_Homo sapiens_hsa003500.65430328
91Folate biosynthesis_Homo sapiens_hsa007900.62975526
92Carbon metabolism_Homo sapiens_hsa012000.62515880
93Caffeine metabolism_Homo sapiens_hsa002320.61689066
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61237262
95beta-Alanine metabolism_Homo sapiens_hsa004100.60567615
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59330681
97African trypanosomiasis_Homo sapiens_hsa051430.58734363
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58596374
99mRNA surveillance pathway_Homo sapiens_hsa030150.58203333
100Fat digestion and absorption_Homo sapiens_hsa049750.56797408
101Metabolic pathways_Homo sapiens_hsa011000.56308540
102Vitamin digestion and absorption_Homo sapiens_hsa049770.55451754
103Other glycan degradation_Homo sapiens_hsa005110.54835699
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53958792
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53045177
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53020454
107Malaria_Homo sapiens_hsa051440.52716495
108Glutathione metabolism_Homo sapiens_hsa004800.52548184
109Peroxisome_Homo sapiens_hsa041460.50952690
110Epstein-Barr virus infection_Homo sapiens_hsa051690.50754114
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50618612
112Glycerolipid metabolism_Homo sapiens_hsa005610.47693799
113Fatty acid biosynthesis_Homo sapiens_hsa000610.46380734
114Chemical carcinogenesis_Homo sapiens_hsa052040.45790446
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44534066
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.43728839
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.42861002
118Phenylalanine metabolism_Homo sapiens_hsa003600.42412106
119Histidine metabolism_Homo sapiens_hsa003400.41994502
120Hippo signaling pathway_Homo sapiens_hsa043900.40965953
121Rheumatoid arthritis_Homo sapiens_hsa053230.39519985
122Cardiac muscle contraction_Homo sapiens_hsa042600.39276271
123TGF-beta signaling pathway_Homo sapiens_hsa043500.38945067
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38852131
125Influenza A_Homo sapiens_hsa051640.38244226
126Regulation of autophagy_Homo sapiens_hsa041400.37090736
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37079639
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36804442
129Sulfur metabolism_Homo sapiens_hsa009200.35800232
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.35136775
131Tryptophan metabolism_Homo sapiens_hsa003800.30120444
132Renin-angiotensin system_Homo sapiens_hsa046140.30107119
133Basal cell carcinoma_Homo sapiens_hsa052170.28165934
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.27880848
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27129835
136Thyroid cancer_Homo sapiens_hsa052160.23712867

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