SCO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.09314439
2L-phenylalanine catabolic process (GO:0006559)7.09314439
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.97255618
4L-phenylalanine metabolic process (GO:0006558)6.97255618
5aromatic amino acid family catabolic process (GO:0009074)6.34491668
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.19333791
7tryptophan catabolic process (GO:0006569)5.78931076
8indole-containing compound catabolic process (GO:0042436)5.78931076
9indolalkylamine catabolic process (GO:0046218)5.78931076
10kynurenine metabolic process (GO:0070189)5.62048374
11bile acid biosynthetic process (GO:0006699)5.56026192
12glyoxylate metabolic process (GO:0046487)5.53422246
13tryptophan metabolic process (GO:0006568)5.49637177
14cysteine metabolic process (GO:0006534)5.43860609
15sulfur amino acid catabolic process (GO:0000098)5.23894060
16high-density lipoprotein particle remodeling (GO:0034375)5.23141722
17negative regulation of fibrinolysis (GO:0051918)5.15007856
18serine family amino acid catabolic process (GO:0009071)5.08986364
19response to peptidoglycan (GO:0032494)5.05108018
20alpha-linolenic acid metabolic process (GO:0036109)5.04411293
21urea cycle (GO:0000050)5.02478791
22urea metabolic process (GO:0019627)5.02478791
23regulation of fibrinolysis (GO:0051917)4.97911843
24glycine metabolic process (GO:0006544)4.89648860
25positive regulation by symbiont of host defense response (GO:0052509)4.89085329
26modulation by symbiont of host defense response (GO:0052031)4.89085329
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.89085329
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.89085329
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.89085329
30modulation by symbiont of host immune response (GO:0052553)4.89085329
31peptidyl-glutamic acid carboxylation (GO:0017187)4.85990080
32protein carboxylation (GO:0018214)4.85990080
33immunoglobulin mediated immune response (GO:0016064)4.80299877
34regulation of protein activation cascade (GO:2000257)4.79237384
35aromatic amino acid family metabolic process (GO:0009072)4.77510594
36neutrophil activation involved in immune response (GO:0002283)4.71975527
37regulation of cholesterol esterification (GO:0010872)4.71796520
38negative regulation of interleukin-12 production (GO:0032695)4.69531461
39bile acid metabolic process (GO:0008206)4.67551750
40detection of bacterium (GO:0016045)4.67452887
41nitrogen cycle metabolic process (GO:0071941)4.65370864
42detection of other organism (GO:0098543)4.62811594
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.62421742
44regulation of triglyceride catabolic process (GO:0010896)4.58068667
45complement activation, alternative pathway (GO:0006957)4.57087502
46serine family amino acid biosynthetic process (GO:0009070)4.50916766
47negative regulation of cholesterol transport (GO:0032375)4.46335676
48negative regulation of sterol transport (GO:0032372)4.46335676
49regulation of complement activation (GO:0030449)4.45777470
50reverse cholesterol transport (GO:0043691)4.44794525
51macrophage activation involved in immune response (GO:0002281)4.44396712
52serine family amino acid metabolic process (GO:0009069)4.43701539
53phospholipid efflux (GO:0033700)4.43054310
54coenzyme catabolic process (GO:0009109)4.42864086
55antigen processing and presentation of endogenous antigen (GO:0019883)4.42419412
56protein-lipid complex remodeling (GO:0034368)4.42398434
57macromolecular complex remodeling (GO:0034367)4.42398434
58plasma lipoprotein particle remodeling (GO:0034369)4.42398434
59amino-acid betaine metabolic process (GO:0006577)4.38434667
60tyrosine metabolic process (GO:0006570)4.37608356
61alpha-amino acid catabolic process (GO:1901606)4.35501099
62imidazole-containing compound metabolic process (GO:0052803)4.35176863
63acylglycerol homeostasis (GO:0055090)4.35128600
64triglyceride homeostasis (GO:0070328)4.35128600
65cellular ketone body metabolic process (GO:0046950)4.34087761
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.32271925
67negative regulation of cell killing (GO:0031342)4.32271925
68type I interferon signaling pathway (GO:0060337)4.30090896
69cellular response to type I interferon (GO:0071357)4.30090896
70response to type I interferon (GO:0034340)4.24717235
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15254850
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14880393
73lysine metabolic process (GO:0006553)4.14748584
74lysine catabolic process (GO:0006554)4.14748584
75homocysteine metabolic process (GO:0050667)4.14073041
76indolalkylamine metabolic process (GO:0006586)4.13382388
77aldehyde catabolic process (GO:0046185)4.10637599
78bile acid and bile salt transport (GO:0015721)4.10317132
79cellular amino acid catabolic process (GO:0009063)4.02402744
80amine catabolic process (GO:0009310)4.00999286
81cellular biogenic amine catabolic process (GO:0042402)4.00999286
82ethanol oxidation (GO:0006069)3.99556153
83NIK/NF-kappaB signaling (GO:0038061)3.97514881
84blood coagulation, intrinsic pathway (GO:0007597)3.97104466
85plasma lipoprotein particle clearance (GO:0034381)3.95029657
86positive regulation of gamma-delta T cell activation (GO:0046645)3.93059398
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90282208
88detection of external biotic stimulus (GO:0098581)3.85935063
89cofactor catabolic process (GO:0051187)3.84559857
90glutamate metabolic process (GO:0006536)3.84116393
91cellular glucuronidation (GO:0052695)3.82233108
92arginine metabolic process (GO:0006525)3.80037786
93positive regulation of lipoprotein lipase activity (GO:0051006)3.79210194
94positive regulation of triglyceride lipase activity (GO:0061365)3.79210194
95cellular modified amino acid catabolic process (GO:0042219)3.79097057
96L-serine metabolic process (GO:0006563)3.78127838
97cholesterol efflux (GO:0033344)3.76978666
98benzene-containing compound metabolic process (GO:0042537)3.75925758
99plasma lipoprotein particle assembly (GO:0034377)3.75694371
100ketone body metabolic process (GO:1902224)3.75045845
101low-density lipoprotein particle remodeling (GO:0034374)3.72827013
102regulation of interferon-beta biosynthetic process (GO:0045357)3.71749640
103NAD biosynthetic process (GO:0009435)3.68168615
104B cell mediated immunity (GO:0019724)3.65925848
105interferon-gamma-mediated signaling pathway (GO:0060333)3.62910727
106fibrinolysis (GO:0042730)3.61264013
107carboxylic acid catabolic process (GO:0046395)3.55371071
108organic acid catabolic process (GO:0016054)3.55371071
109pyridine nucleotide biosynthetic process (GO:0019363)3.54259417
110nicotinamide nucleotide biosynthetic process (GO:0019359)3.54259417
111opsonization (GO:0008228)3.53560257
112complement activation, classical pathway (GO:0006958)3.53043525
113lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51705731
114very-low-density lipoprotein particle assembly (GO:0034379)3.47409845
115protein activation cascade (GO:0072376)3.45529388
116pyrimidine nucleoside catabolic process (GO:0046135)3.43982628
117response to nitrosative stress (GO:0051409)3.42949312
118detection of biotic stimulus (GO:0009595)3.42749382
119response to interferon-beta (GO:0035456)3.40561247
120detection of molecule of bacterial origin (GO:0032490)3.39680523
121complement activation (GO:0006956)3.39486555
122regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36606855
123cholesterol homeostasis (GO:0042632)3.35639534
124glucuronate metabolic process (GO:0019585)3.33793859
125uronic acid metabolic process (GO:0006063)3.33793859
126response to host immune response (GO:0052572)3.32030842
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32030842
128cytolysis (GO:0019835)3.31305534
129one-carbon metabolic process (GO:0006730)3.31027370
130leukocyte aggregation (GO:0070486)3.30541352
131respiratory burst (GO:0045730)3.30320073
132negative regulation of myeloid cell apoptotic process (GO:0033033)3.30114724
133regulation of mast cell degranulation (GO:0043304)3.30077819
134plasma lipoprotein particle organization (GO:0071827)3.29607103
135negative regulation of lipase activity (GO:0060192)3.28686379
136flavonoid metabolic process (GO:0009812)3.28605371
137sterol homeostasis (GO:0055092)3.28571465
138protein-lipid complex assembly (GO:0065005)3.28310641
139dicarboxylic acid biosynthetic process (GO:0043650)3.25523532
140positive regulation of antigen processing and presentation (GO:0002579)3.24397201
141myeloid cell activation involved in immune response (GO:0002275)3.21714784
142pyrimidine nucleoside salvage (GO:0043097)3.19460564
143pyrimidine-containing compound salvage (GO:0008655)3.19460564
144negative regulation of innate immune response (GO:0045824)3.17897953
145regulation of antigen processing and presentation (GO:0002577)3.17439624
146defense response to protozoan (GO:0042832)3.16725078
147myeloid dendritic cell differentiation (GO:0043011)3.13621773
148germinal center formation (GO:0002467)3.11589409
149positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10751448
150granulocyte activation (GO:0036230)3.08335273
151response to protozoan (GO:0001562)3.05615577
152negative regulation of cytokine production involved in immune response (GO:0002719)3.04171797
153response to muramyl dipeptide (GO:0032495)3.03359240
154myeloid dendritic cell activation (GO:0001773)3.00891274
155regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99535262
156response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99304697
157response to host (GO:0075136)2.99304697
158response to host defenses (GO:0052200)2.99304697
159macrophage activation (GO:0042116)2.98904802
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97212390
161positive regulation of type 2 immune response (GO:0002830)2.96774609
162neutrophil activation (GO:0042119)2.94792628
163negative regulation of erythrocyte differentiation (GO:0045647)2.94598572
164regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94028661
165regulation of mast cell activation involved in immune response (GO:0033006)2.92324262
166regulation of interferon-alpha production (GO:0032647)2.91404500
167positive regulation of Cdc42 GTPase activity (GO:0043089)2.89940316
168negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.87916862
169regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87666600
170T-helper 1 type immune response (GO:0042088)2.87077282
171response to interferon-alpha (GO:0035455)2.86532852
172positive regulation of interferon-alpha production (GO:0032727)2.86503740
173cellular response to interferon-gamma (GO:0071346)2.85965665
174negative regulation of lymphocyte mediated immunity (GO:0002707)2.84368137
175regulation of T cell tolerance induction (GO:0002664)2.82949020
176regulation of leukocyte degranulation (GO:0043300)2.82654397
177antigen processing and presentation via MHC class Ib (GO:0002475)2.79808650
178negative regulation of leukocyte mediated immunity (GO:0002704)2.77146891
179positive regulation of mast cell activation (GO:0033005)2.76975989
180response to interferon-gamma (GO:0034341)2.76710201
181regulation of T-helper 2 cell differentiation (GO:0045628)2.75440001
182negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.74101901
183regulation of tolerance induction (GO:0002643)2.72029753
184hydrogen peroxide biosynthetic process (GO:0050665)2.71595408
185microglial cell activation (GO:0001774)2.70512828
186positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70034769
187regulation of gamma-delta T cell activation (GO:0046643)2.64848351
188leukocyte migration involved in inflammatory response (GO:0002523)2.64568150
189amino sugar catabolic process (GO:0046348)2.63918100
190positive regulation of mast cell degranulation (GO:0043306)2.61711057
191positive regulation of mast cell activation involved in immune response (GO:0033008)2.61711057
192regulation of mast cell activation (GO:0033003)2.58367580
193negative regulation of viral genome replication (GO:0045071)2.56861771
194regulation of type 2 immune response (GO:0002828)2.56004499
195regulation of cytokine secretion involved in immune response (GO:0002739)2.54013543
196regulation of superoxide anion generation (GO:0032928)2.53626631
197negative regulation of T cell mediated immunity (GO:0002710)2.52048642
198cellular response to interferon-beta (GO:0035458)2.50904724
199regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49931548
200positive regulation of interferon-beta production (GO:0032728)2.48609662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.00662714
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.11957113
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.98192636
4CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.99867858
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.94194903
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.63468542
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.23427443
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03545373
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.16688224
10* VDR_21846776_ChIP-Seq_THP-1_Human3.16376673
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.99603713
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63081969
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41352794
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39670166
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19475209
16VDR_24763502_ChIP-Seq_THP-1_Human2.16000882
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12850671
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08056517
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06029375
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1712511
21MYC_22102868_ChIP-Seq_BL_Human1.97893358
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97881390
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96420681
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.92498604
25SPI1_23547873_ChIP-Seq_NB4_Human1.90739831
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.90693617
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.89318783
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86059231
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85182472
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85005453
31MAF_26560356_Chip-Seq_TH1_Human1.84561806
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75872683
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74815890
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66352070
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65670257
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.65216790
37MAF_26560356_Chip-Seq_TH2_Human1.64710506
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64333477
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63871638
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60498985
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.59009871
42UTX_26944678_Chip-Seq_JUKART_Human1.57878352
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57122168
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.56088778
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53988509
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.50833504
47PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49127808
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49044568
49GATA1_22025678_ChIP-Seq_K562_Human1.48338818
50RACK7_27058665_Chip-Seq_MCF-7_Human1.47121386
51P68_20966046_ChIP-Seq_HELA_Human1.46347211
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45394727
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44212865
54KDM2B_26808549_Chip-Seq_DND41_Human1.42968685
55SPI1_23127762_ChIP-Seq_K562_Human1.42265508
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42056164
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.40194479
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.39920833
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36362617
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34933368
61* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34756635
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.34492548
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.33208036
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32684342
65* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31659356
66TCF7_22412390_ChIP-Seq_EML_Mouse1.30595493
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29330549
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.25961457
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23883954
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23721480
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21510003
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21109483
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.20975185
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19327332
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18201552
76ZNF263_19887448_ChIP-Seq_K562_Human1.18064707
77HTT_18923047_ChIP-ChIP_STHdh_Human1.17803897
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12725376
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12450466
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11686920
81E2F1_20622854_ChIP-Seq_HELA_Human1.10440637
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10432317
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09954971
84SA1_27219007_Chip-Seq_Bcells_Human1.09886663
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09611226
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.09009241
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08680396
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07989383
89DCP1A_22483619_ChIP-Seq_HELA_Human1.07988922
90SMC4_20622854_ChIP-Seq_HELA_Human1.06683345
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06014148
92PHF8_20622854_ChIP-Seq_HELA_Human1.05360209
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05022381
94* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04561108
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04518503
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04452889
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04163404
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03620157
99MYB_26560356_Chip-Seq_TH2_Human1.03410680
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02866688
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02225858
102MYB_26560356_Chip-Seq_TH1_Human1.01124899
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.00676233
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00597370
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00351403
106* TFEB_21752829_ChIP-Seq_HELA_Human0.99872479
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99487252
108* GABP_19822575_ChIP-Seq_HepG2_Human0.97951995
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97582495
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97318104
111* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97299700
112* HNF4A_19822575_ChIP-Seq_HepG2_Human0.97154724
113* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96948893
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.95211438
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94087896
116XRN2_22483619_ChIP-Seq_HELA_Human0.92867715
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91758032
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89377101
119FOXP3_21729870_ChIP-Seq_TREG_Human0.87470686
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87005710
121ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84794309
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.84757883
123CLOCK_20551151_ChIP-Seq_293T_Human0.84555736
124VDR_23849224_ChIP-Seq_CD4+_Human0.84101916
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83848079
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.83802898
127ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81880458
128MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81320979
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81142047
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79266791
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.78087168
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76487770
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76300595
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76263241
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75288883
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73679579
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71873896
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.71672145
139YY1_21170310_ChIP-Seq_MESCs_Mouse0.70871227
140* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70623922
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69821563
142BCL6_27268052_Chip-Seq_Bcells_Human0.68841055
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68341234
144NELFA_20434984_ChIP-Seq_ESCs_Mouse0.67234914
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.65991675
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.65460781
147LXR_22292898_ChIP-Seq_THP-1_Human0.64540838
148HOXB4_20404135_ChIP-ChIP_EML_Mouse0.64464599
149BCOR_27268052_Chip-Seq_Bcells_Human0.64329699
150MYC_18940864_ChIP-ChIP_HL60_Human0.64294735
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64187861
152FOXA2_19822575_ChIP-Seq_HepG2_Human0.62526663
153* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.62315481
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61574403
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.61230918
156AR_20517297_ChIP-Seq_VCAP_Human0.60848502
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60561773
158CTCF_21964334_Chip-Seq_Bcells_Human0.59871740
159SCL_19346495_ChIP-Seq_HPC-7_Human0.58157797
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.57825897
161EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.57688364
162* CTCF_26484167_Chip-Seq_Bcells_Mouse0.57625934
163ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.57195988
164IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.57131644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.04851426
2MP0005360_urolithiasis6.94998694
3MP0005365_abnormal_bile_salt5.98934091
4MP0005085_abnormal_gallbladder_physiolo5.96893009
5MP0003806_abnormal_nucleotide_metabolis5.13968401
6MP0008875_abnormal_xenobiotic_pharmacok4.77836865
7MP0003303_peritoneal_inflammation4.04434603
8MP0009840_abnormal_foam_cell3.90593825
9MP0001835_abnormal_antigen_presentation3.48164314
10MP0003252_abnormal_bile_duct3.47152711
11MP0010329_abnormal_lipoprotein_level3.45015006
12MP0002148_abnormal_hypersensitivity_rea2.80974568
13MP0005083_abnormal_biliary_tract2.79420097
14MP0005387_immune_system_phenotype2.75284994
15MP0001790_abnormal_immune_system2.75284994
16MP0005332_abnormal_amino_acid2.67237155
17MP0001666_abnormal_nutrient_absorption2.65080583
18MP0003195_calcinosis2.61364079
19MP0005000_abnormal_immune_tolerance2.57839411
20MP0005671_abnormal_response_to2.56366402
21MP0008260_abnormal_autophagy2.45625086
22MP0001800_abnormal_humoral_immune2.41135624
23MP0003191_abnormal_cellular_cholesterol2.39667782
24MP0002723_abnormal_immune_serum2.32496684
25MP0002452_abnormal_antigen_presenting2.29655730
26MP0004510_myositis2.15763221
27* MP0000609_abnormal_liver_physiology2.10698310
28MP0001819_abnormal_immune_cell2.10479551
29MP0002420_abnormal_adaptive_immunity2.10280531
30MP0005451_abnormal_body_composition2.02035324
31MP0002118_abnormal_lipid_homeostasis1.95310243
32MP0003172_abnormal_lysosome_physiology1.93380244
33MP0005319_abnormal_enzyme/_coenzyme1.91276971
34MP0001533_abnormal_skeleton_physiology1.91167239
35MP0009278_abnormal_bone_marrow1.85956787
36MP0004019_abnormal_vitamin_homeostasis1.85816905
37MP0001764_abnormal_homeostasis1.85062757
38MP0009697_abnormal_copulation1.84025307
39MP0010155_abnormal_intestine_physiology1.82081429
40MP0003186_abnormal_redox_activity1.72875233
41MP0003868_abnormal_feces_composition1.69073481
42MP0000858_altered_metastatic_potential1.68724276
43MP0003300_gastrointestinal_ulcer1.68529293
44MP0005584_abnormal_enzyme/coenzyme_acti1.68437547
45MP0004947_skin_inflammation1.68334078
46MP0000343_altered_response_to1.67638613
47MP0002405_respiratory_system_inflammati1.63895579
48MP0000716_abnormal_immune_system1.57344281
49MP0003656_abnormal_erythrocyte_physiolo1.56223614
50MP0002138_abnormal_hepatobiliary_system1.49770586
51MP0006036_abnormal_mitochondrial_physio1.46919799
52MP0002398_abnormal_bone_marrow1.44318159
53MP0003011_delayed_dark_adaptation1.43303870
54MP0003183_abnormal_peptide_metabolism1.41776100
55MP0005310_abnormal_salivary_gland1.40603646
56MP0000465_gastrointestinal_hemorrhage1.39731171
57MP0003763_abnormal_thymus_physiology1.39284206
58MP0002429_abnormal_blood_cell1.30812697
59MP0003453_abnormal_keratinocyte_physiol1.30264104
60MP0000598_abnormal_liver_morphology1.22823926
61MP0003448_altered_tumor_morphology1.19561660
62MP0002722_abnormal_immune_system1.18612486
63MP0000689_abnormal_spleen_morphology1.18557123
64MP0006035_abnormal_mitochondrial_morpho1.18139369
65MP0009643_abnormal_urine_homeostasis1.17745992
66MP0001873_stomach_inflammation1.16551159
67MP0008004_abnormal_stomach_pH1.15161954
68MP0002277_abnormal_respiratory_mucosa1.12750221
69MP0008469_abnormal_protein_level1.09941952
70MP0010368_abnormal_lymphatic_system1.09839462
71MP0002998_abnormal_bone_remodeling1.08892407
72MP0009764_decreased_sensitivity_to1.07207160
73MP0005647_abnormal_sex_gland1.06527917
74MP0009763_increased_sensitivity_to1.03531662
75MP0003866_abnormal_defecation1.02605673
76MP0003828_pulmonary_edema1.01950103
77MP0000604_amyloidosis0.99013943
78* MP0005636_abnormal_mineral_homeostasis0.98565244
79MP0000490_abnormal_crypts_of0.95448286
80MP0005084_abnormal_gallbladder_morpholo0.94126952
81MP0009642_abnormal_blood_homeostasis0.92333303
82* MP0005376_homeostasis/metabolism_phenot0.92286330
83MP0009379_abnormal_foot_pigmentation0.89321281
84MP0001663_abnormal_digestive_system0.88963215
85MP0003718_maternal_effect0.84745047
86MP0009765_abnormal_xenobiotic_induced0.83398674
87MP0002254_reproductive_system_inflammat0.82728061
88MP0002132_abnormal_respiratory_system0.82286982
89* MP0005266_abnormal_metabolism0.82064931
90MP0005390_skeleton_phenotype0.81810973
91MP0000703_abnormal_thymus_morphology0.81032881
92MP0003436_decreased_susceptibility_to0.79812883
93MP0001853_heart_inflammation0.77355181
94MP0005220_abnormal_exocrine_pancreas0.76763256
95MP0005464_abnormal_platelet_physiology0.76286531
96MP0005408_hypopigmentation0.74945421
97MP0003724_increased_susceptibility_to0.74590329
98MP0001851_eye_inflammation0.73240074
99MP0006082_CNS_inflammation0.71999545
100MP0004147_increased_porphyrin_level0.66954721
101MP0005075_abnormal_melanosome_morpholog0.66685117
102MP0002078_abnormal_glucose_homeostasis0.66143310
103MP0002796_impaired_skin_barrier0.63598890
104MP0004858_abnormal_nervous_system0.62642858
105MP0002876_abnormal_thyroid_physiology0.62554161
106MP0005165_increased_susceptibility_to0.61682698
107MP0005334_abnormal_fat_pad0.60931623
108MP0004381_abnormal_hair_follicle0.60684652
109MP0003690_abnormal_glial_cell0.60021147
110MP0002933_joint_inflammation0.58258343
111MP0009785_altered_susceptibility_to0.57559441
112MP0008873_increased_physiological_sensi0.57376601
113MP0003795_abnormal_bone_structure0.56395810
114MP0004883_abnormal_blood_vessel0.55677189
115MP0002971_abnormal_brown_adipose0.55069043
116MP0003705_abnormal_hypodermis_morpholog0.54917889
117MP0001661_extended_life_span0.54085510
118MP0000015_abnormal_ear_pigmentation0.53948385
119MP0005448_abnormal_energy_balance0.53936174
120MP0000639_abnormal_adrenal_gland0.53882427
121MP0002653_abnormal_ependyma_morphology0.53343209
122MP0000678_abnormal_parathyroid_gland0.52734951
123MP0004185_abnormal_adipocyte_glucose0.52728557
124MP0009931_abnormal_skin_appearance0.52002313
125MP0005381_digestive/alimentary_phenotyp0.51713537
126MP0002019_abnormal_tumor_incidence0.51629009
127MP0005535_abnormal_body_temperature0.51080868
128MP0003329_amyloid_beta_deposits0.50821204
129MP0003638_abnormal_response/metabolism_0.50374266
130MP0001845_abnormal_inflammatory_respons0.47660407
131MP0001756_abnormal_urination0.46476933
132MP0005025_abnormal_response_to0.42435471
133MP0005058_abnormal_lysosome_morphology0.40827983
134MP0000685_abnormal_immune_system0.40414953
135MP0004782_abnormal_surfactant_physiolog0.39936733
136MP0002136_abnormal_kidney_physiology0.39396313
137MP0005395_other_phenotype0.39021601
138MP0002970_abnormal_white_adipose0.38769621
139MP0003953_abnormal_hormone_level0.37278942
140MP0005166_decreased_susceptibility_to0.36053919
141MP0005397_hematopoietic_system_phenotyp0.35657973
142MP0001545_abnormal_hematopoietic_system0.35657973
143MP0008872_abnormal_physiological_respon0.34935529
144MP0000358_abnormal_cell_content/0.34354656
145MP0008874_decreased_physiological_sensi0.34281714
146MP0002822_catalepsy0.33244656
147MP0009384_cardiac_valve_regurgitation0.31238954
148MP0000249_abnormal_blood_vessel0.30833548
149MP0004130_abnormal_muscle_cell0.29218609
150MP0003075_altered_response_to0.29174041
151MP0000230_abnormal_systemic_arterial0.29120751
152MP0005670_abnormal_white_adipose0.28667699
153MP0002419_abnormal_innate_immunity0.28018020
154MP0009672_abnormal_birth_weight0.27189907
155MP0009053_abnormal_anal_canal0.26133442
156MP0001542_abnormal_bone_strength0.26126994
157MP0009333_abnormal_splenocyte_physiolog0.25763891
158MP0009115_abnormal_fat_cell0.25260439
159MP0005164_abnormal_response_to0.24481137

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.14765026
2Hypobetalipoproteinemia (HP:0003563)6.48514802
3Intrahepatic cholestasis (HP:0001406)6.48288754
4Deep venous thrombosis (HP:0002625)6.18785168
5Prolonged partial thromboplastin time (HP:0003645)6.03123013
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00104269
7Xanthomatosis (HP:0000991)5.65871109
8Hyperlipoproteinemia (HP:0010980)5.37837307
9Abnormality of macrophages (HP:0004311)5.08998475
10Recurrent bacterial skin infections (HP:0005406)4.98623073
11Recurrent abscess formation (HP:0002722)4.93680274
12Eczematoid dermatitis (HP:0000976)4.90314792
13Hyperglycinemia (HP:0002154)4.54766713
14Hypolipoproteinemia (HP:0010981)4.48981723
15Hyperammonemia (HP:0001987)4.37760623
16Complement deficiency (HP:0004431)4.34475780
17Abnormality of liposaccharide metabolism (HP:0010968)4.23571139
18Abnormality of glycosphingolipid metabolism (HP:0004343)4.23571139
19Abnormality of glycolipid metabolism (HP:0010969)4.23571139
20Myositis (HP:0100614)4.18538599
21Joint hemorrhage (HP:0005261)4.15005838
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.05582505
23Hyperglycinuria (HP:0003108)4.00292069
24Elevated erythrocyte sedimentation rate (HP:0003565)4.00265133
25Orchitis (HP:0100796)3.97987732
26Abnormality of methionine metabolism (HP:0010901)3.93465091
27Ketosis (HP:0001946)3.90458126
28Abnormality of glycine metabolism (HP:0010895)3.90076046
29Abnormality of serine family amino acid metabolism (HP:0010894)3.90076046
30Abnormality of the common coagulation pathway (HP:0010990)3.88489228
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.86514773
32Fat malabsorption (HP:0002630)3.84334810
33Mediastinal lymphadenopathy (HP:0100721)3.82270815
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78394645
35Obstructive lung disease (HP:0006536)3.75732816
36Chronic obstructive pulmonary disease (HP:0006510)3.75732816
37Abnormality of the intrinsic pathway (HP:0010989)3.73337919
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.65045302
39Retrobulbar optic neuritis (HP:0100654)3.64064467
40Optic neuritis (HP:0100653)3.64064467
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.64019315
42Abnormality of pyrimidine metabolism (HP:0004353)3.62718153
43Hypoglycemic coma (HP:0001325)3.58437717
44Loss of speech (HP:0002371)3.55467740
45Hypoalphalipoproteinemia (HP:0003233)3.54124055
46Abnormality of fatty-acid metabolism (HP:0004359)3.50391019
47Epidermoid cyst (HP:0200040)3.49370246
48Increased cerebral lipofuscin (HP:0011813)3.49055659
49Petechiae (HP:0000967)3.33347775
50Abnormality of serum amino acid levels (HP:0003112)3.32394802
51Hyperbilirubinemia (HP:0002904)3.24987894
52Gastrointestinal infarctions (HP:0005244)3.23077162
53Stomatitis (HP:0010280)3.21703366
54Hypercholesterolemia (HP:0003124)3.18586853
55Abnormality of complement system (HP:0005339)3.17672024
56Delayed CNS myelination (HP:0002188)3.10938169
57Dysostosis multiplex (HP:0000943)3.09551428
58Meningitis (HP:0001287)3.09147419
59Conjugated hyperbilirubinemia (HP:0002908)3.07953346
60Recurrent skin infections (HP:0001581)3.07056633
61Spontaneous abortion (HP:0005268)3.02044932
62Vacuolated lymphocytes (HP:0001922)3.02026312
63Increased neuronal autofluorescent lipopigment (HP:0002074)3.01733147
64Steatorrhea (HP:0002570)3.01659254
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.99796270
66Dicarboxylic aciduria (HP:0003215)2.99796270
67Recurrent fungal infections (HP:0002841)2.99285754
68Urticaria (HP:0001025)2.97221191
69Malnutrition (HP:0004395)2.95728282
70Lethargy (HP:0001254)2.88579291
71Increased IgE level (HP:0003212)2.86421007
72Metabolic acidosis (HP:0001942)2.85496497
73Abnormality of nucleobase metabolism (HP:0010932)2.83032962
74Cerebral edema (HP:0002181)2.82780704
75Vasculitis (HP:0002633)2.81481694
76Purpura (HP:0000979)2.78270655
77Hepatosplenomegaly (HP:0001433)2.74559839
78Ragged-red muscle fibers (HP:0003200)2.72346637
79Nasal polyposis (HP:0100582)2.69321143
80Gingivitis (HP:0000230)2.65471738
81Ketoacidosis (HP:0001993)2.64103037
82Abnormality of the nasal mucosa (HP:0000433)2.62515646
83Hepatocellular carcinoma (HP:0001402)2.58952196
84Increased IgM level (HP:0003496)2.54863843
85Cellulitis (HP:0100658)2.54448993
86Brushfield spots (HP:0001088)2.48412897
87Gout (HP:0001997)2.48108677
88Recurrent cutaneous fungal infections (HP:0011370)2.47593900
89Chronic mucocutaneous candidiasis (HP:0002728)2.47593900
90Pulmonary infiltrates (HP:0002113)2.47236835
91Acanthocytosis (HP:0001927)2.47137240
92Late onset (HP:0003584)2.47104715
93Progressive neurologic deterioration (HP:0002344)2.46871541
94Hemoptysis (HP:0002105)2.46122434
95Keratoconjunctivitis sicca (HP:0001097)2.45307469
96Encephalitis (HP:0002383)2.43590229
97Abnormality of purine metabolism (HP:0004352)2.43190367
98Systemic lupus erythematosus (HP:0002725)2.42039004
99Opisthotonus (HP:0002179)2.39189647
100Recurrent viral infections (HP:0004429)2.37201141
101Myocardial infarction (HP:0001658)2.35328694
102Hypertensive crisis (HP:0100735)2.34514905
103Axonal loss (HP:0003447)2.34490197
104Abnormal gallbladder physiology (HP:0012438)2.29470211
105Cholecystitis (HP:0001082)2.29470211
106Colitis (HP:0002583)2.28933035
107Hepatic necrosis (HP:0002605)2.28650821
108Skin nodule (HP:0200036)2.26993219
109Anorexia (HP:0002039)2.26981113
110Abnormality of iron homeostasis (HP:0011031)2.26707010
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25895215
112Gastrointestinal inflammation (HP:0004386)2.25110967
113Spastic diplegia (HP:0001264)2.25031210
114Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24961779
115Abnormality of polysaccharide metabolism (HP:0011012)2.24961779
116Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24961779
117Vomiting (HP:0002013)2.24731559
118Neonatal onset (HP:0003623)2.24288997
119Vascular calcification (HP:0004934)2.23948377
120Abnormal delayed hypersensitivity skin test (HP:0002963)2.23915168
121Keratoconjunctivitis (HP:0001096)2.22873952
122Inflammation of the large intestine (HP:0002037)2.22435794
123Prolonged neonatal jaundice (HP:0006579)2.22200821
124Generalized aminoaciduria (HP:0002909)2.20943081
125Abnormality of transition element cation homeostasis (HP:0011030)2.19707655
126Irritability (HP:0000737)2.17793049
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17409492
128Premature loss of primary teeth (HP:0006323)2.16938125
129Chest pain (HP:0100749)2.15157342
130Pustule (HP:0200039)2.14986931
131Hypergammaglobulinemia (HP:0010702)2.14426117
132Increased serum ferritin (HP:0003281)2.13428649
133Hypochromic microcytic anemia (HP:0004840)2.13289637
134Disinhibition (HP:0000734)2.11342294
135Gastrointestinal stroma tumor (HP:0100723)2.11029240
136Gangrene (HP:0100758)2.09386769
137Reduced antithrombin III activity (HP:0001976)2.09173930
138Mutism (HP:0002300)2.08786942
139Episodic fever (HP:0001954)2.08215879
140Polygenic inheritance (HP:0010982)2.07959312
141Pancreatitis (HP:0001733)2.06794636
142Abnormal cartilage morphology (HP:0002763)2.06109361
143Abnormal gallbladder morphology (HP:0012437)2.05682191
144Autoimmune thrombocytopenia (HP:0001973)2.05645211
145Thrombophlebitis (HP:0004418)2.05488761
146Menorrhagia (HP:0000132)2.05267659
147Cholelithiasis (HP:0001081)2.04537094
148Mucopolysacchariduria (HP:0008155)2.02631647
149Urinary glycosaminoglycan excretion (HP:0003541)2.02631647
150Glomerulonephritis (HP:0000099)2.01174815
151Gingival bleeding (HP:0000225)2.00801378
152Interstitial pulmonary disease (HP:0006530)2.00032555
153Hypoglycemic seizures (HP:0002173)1.99872057
154Amyloidosis (HP:0011034)1.99077526
155Elevated hepatic transaminases (HP:0002910)1.97964468
156Poikilocytosis (HP:0004447)1.97418618
157Glycosuria (HP:0003076)1.95671602
158Abnormality of urine glucose concentration (HP:0011016)1.95671602
159Acute encephalopathy (HP:0006846)1.95479300
160Abnormality of the heme biosynthetic pathway (HP:0010472)1.95061912
161Osteomyelitis (HP:0002754)1.93802509
162Sensorimotor neuropathy (HP:0007141)1.92230379
163Spastic paraparesis (HP:0002313)1.91794083
164Recurrent gram-negative bacterial infections (HP:0005420)1.91301558
165Skin rash (HP:0000988)1.91120781
166Cardiovascular calcification (HP:0011915)1.90816895
167Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90683003
168Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88281717
169Skin ulcer (HP:0200042)1.87664124
170Increased muscle lipid content (HP:0009058)1.87301817
171* Lactic acidosis (HP:0003128)1.87049881
172Nausea (HP:0002018)1.85368081
173Lymphopenia (HP:0001888)1.85148827
174Megaloblastic anemia (HP:0001889)1.85051488
175Cheilitis (HP:0100825)1.84584765
176Increased serum pyruvate (HP:0003542)1.84044083
177Abnormality of glycolysis (HP:0004366)1.84044083
178Abnormality of the pleura (HP:0002103)1.83417760
179Upper motor neuron abnormality (HP:0002127)1.83116926
180Epistaxis (HP:0000421)1.82105179
181Arterial thrombosis (HP:0004420)1.81328062
182Hepatocellular necrosis (HP:0001404)1.80810913
183Agammaglobulinemia (HP:0004432)1.78468396
184Glomerulopathy (HP:0100820)1.77399896
185Recurrent pneumonia (HP:0006532)1.75978628
186Hemorrhage of the eye (HP:0011885)1.75804222
187Thoracic kyphosis (HP:0002942)1.75203475
188Abnormality of cells of the lymphoid lineage (HP:0012140)1.73250495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.13590140
2ERN14.27088692
3NME23.80627131
4RIPK43.10359004
5SIK12.94513324
6FGFR42.80714173
7STK162.62427288
8KDR2.60296699
9FLT32.56785518
10IRAK42.50452410
11PRPF4B2.10228042
12TAOK32.05243210
13CSK1.97208783
14MAP2K31.96389816
15MAP3K111.86250626
16ABL21.83215737
17SMG11.82411640
18TYK21.80246594
19ACVR1B1.73337423
20SIK31.70459340
21MAP3K141.68137911
22ERBB41.67145601
23TNK21.67060402
24TBK11.63412944
25FGR1.56160776
26MAPK111.51746289
27DYRK31.48903882
28PIM21.48486974
29TESK11.43458985
30PKN21.39232454
31KIT1.38993676
32GRK61.35037616
33PIK3CG1.34356060
34WEE11.33675358
35MAP2K41.32132511
36MST1R1.31343822
37MAP2K61.31245405
38FES1.30363106
39MAP4K11.30183884
40MATK1.29622510
41MAP3K31.29002632
42IRAK21.22247311
43EIF2AK11.21547623
44EIF2AK31.19832507
45RPS6KA41.16719798
46ARAF1.14680409
47TGFBR11.14344010
48ADRBK21.02232656
49BUB11.01041122
50MAPK41.00716368
51TRIB30.97311426
52CSF1R0.96844152
53MUSK0.96491419
54INSRR0.96136805
55HCK0.95579554
56CDK40.95122105
57TGFBR20.94299351
58ZAP700.92229598
59PINK10.90347039
60SCYL20.89961358
61GRK70.89755900
62TAOK20.89258070
63CDK190.87745182
64PRKD20.86847653
65TXK0.84875433
66PAK40.84127942
67MAP3K100.83747948
68BLK0.81651671
69CDC42BPA0.80139231
70MAP3K50.79264100
71JAK20.78836795
72EPHB10.78694100
73VRK20.77158123
74PDPK10.76290754
75IRAK30.73647647
76TLK10.73177526
77JAK10.73022717
78LRRK20.72284115
79TIE10.71842510
80LCK0.69778409
81MAP3K60.69454378
82BRAF0.68546824
83BTK0.68300506
84TEC0.67418445
85STK100.66924835
86CAMK2G0.66847930
87MAPK120.65976846
88IRAK10.65365098
89MOS0.63390833
90VRK10.63303811
91CSNK1G30.62198314
92MARK20.61832977
93IKBKE0.60983016
94MAPK150.60058919
95PDK20.58870597
96MARK30.58763984
97BMX0.58371738
98CSNK1G10.57579500
99FRK0.55616309
100PDK10.55202227
101DAPK30.53173196
102NME10.53066097
103RAF10.49994155
104JAK30.49197751
105KSR20.48418879
106CDK80.48128038
107IKBKB0.47925326
108CDK60.46506843
109RIPK10.46329126
110SIK20.44475090
111LATS20.44351946
112DDR20.44289276
113CSNK2A20.43741904
114CSNK2A10.43286499
115RPS6KC10.43248439
116RPS6KL10.43248439
117MAPKAPK20.43008012
118NLK0.42673706
119NEK90.42669456
120MAPKAPK30.41171531
121GRK10.40696702
122LYN0.40556711
123MAP2K20.39556841
124CDK70.39358198
125PRKACG0.38012468
126MYLK0.37354972
127DAPK10.36822779
128ERBB20.36506087
129PTK60.36038056
130CHUK0.35577571
131BRSK20.35491453
132PRKCD0.34517089
133PAK10.34479218
134SYK0.34228103
135PIM10.34132412
136PRKAA20.33681082
137PRKG20.33571828
138RPS6KB20.33429362
139AURKA0.33059086
140TESK20.32728756
141BMPR20.32138747
142DYRK20.31594856
143PRKCZ0.31503072
144TAOK10.31199631
145MAP3K130.30823223
146MAP3K10.29886663
147EIF2AK20.29698225
148RPS6KA60.29536046
149FYN0.29065122
150MAP3K80.28049231

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.35749213
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14378682
3Leishmaniasis_Homo sapiens_hsa051402.96087598
4Allograft rejection_Homo sapiens_hsa053302.88476307
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86708545
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74116636
7Other glycan degradation_Homo sapiens_hsa005112.68011084
8Osteoclast differentiation_Homo sapiens_hsa043802.66923852
9Arginine biosynthesis_Homo sapiens_hsa002202.66629506
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.66624927
11Nitrogen metabolism_Homo sapiens_hsa009102.65325502
12Graft-versus-host disease_Homo sapiens_hsa053322.58127307
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56030661
14Autoimmune thyroid disease_Homo sapiens_hsa053202.52531251
15Complement and coagulation cascades_Homo sapiens_hsa046102.50380281
16Asthma_Homo sapiens_hsa053102.44348406
17Tryptophan metabolism_Homo sapiens_hsa003802.42516173
18Fatty acid degradation_Homo sapiens_hsa000712.35657993
19Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34078418
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24754394
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20867392
22Tuberculosis_Homo sapiens_hsa051522.16446816
23Drug metabolism - other enzymes_Homo sapiens_hsa009832.15817917
24Peroxisome_Homo sapiens_hsa041462.10359860
25Intestinal immune network for IgA production_Homo sapiens_hsa046722.02353025
26Type I diabetes mellitus_Homo sapiens_hsa049401.97422251
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97080212
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96509278
29Antigen processing and presentation_Homo sapiens_hsa046121.96032252
30Rheumatoid arthritis_Homo sapiens_hsa053231.95909866
31Lysosome_Homo sapiens_hsa041421.92846563
32Butanoate metabolism_Homo sapiens_hsa006501.92773176
33Chemical carcinogenesis_Homo sapiens_hsa052041.88960101
34Histidine metabolism_Homo sapiens_hsa003401.86181181
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85886521
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85722670
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.85150716
38Folate biosynthesis_Homo sapiens_hsa007901.81501242
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78473813
40Propanoate metabolism_Homo sapiens_hsa006401.78122422
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.77868787
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77073219
43Legionellosis_Homo sapiens_hsa051341.75584547
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.75086228
45Influenza A_Homo sapiens_hsa051641.73248519
46Viral myocarditis_Homo sapiens_hsa054161.70729554
47Caffeine metabolism_Homo sapiens_hsa002321.70385885
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.69626415
49Selenocompound metabolism_Homo sapiens_hsa004501.68583583
50beta-Alanine metabolism_Homo sapiens_hsa004101.67329912
51PPAR signaling pathway_Homo sapiens_hsa033201.66121230
52Primary immunodeficiency_Homo sapiens_hsa053401.65103616
53Sulfur relay system_Homo sapiens_hsa041221.64910039
54Retinol metabolism_Homo sapiens_hsa008301.63968877
55Herpes simplex infection_Homo sapiens_hsa051681.63541359
56Pertussis_Homo sapiens_hsa051331.62945283
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.60200104
58Fatty acid metabolism_Homo sapiens_hsa012121.59350602
59Phagosome_Homo sapiens_hsa041451.58525193
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57407658
61B cell receptor signaling pathway_Homo sapiens_hsa046621.55523812
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54507407
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52635991
64Toxoplasmosis_Homo sapiens_hsa051451.51961998
65Malaria_Homo sapiens_hsa051441.49730544
66Staphylococcus aureus infection_Homo sapiens_hsa051501.49201364
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.47620655
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47273201
69Phenylalanine metabolism_Homo sapiens_hsa003601.44366107
70Salmonella infection_Homo sapiens_hsa051321.41132780
71Tyrosine metabolism_Homo sapiens_hsa003501.40257970
72Vitamin B6 metabolism_Homo sapiens_hsa007501.37510870
73TNF signaling pathway_Homo sapiens_hsa046681.37362043
74Biosynthesis of amino acids_Homo sapiens_hsa012301.35920228
75Pyruvate metabolism_Homo sapiens_hsa006201.34676554
76Fatty acid elongation_Homo sapiens_hsa000621.34328350
77Measles_Homo sapiens_hsa051621.33137920
78Sulfur metabolism_Homo sapiens_hsa009201.29936573
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29749977
80Carbon metabolism_Homo sapiens_hsa012001.26824162
81Hematopoietic cell lineage_Homo sapiens_hsa046401.25249525
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24763123
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23168372
84Shigellosis_Homo sapiens_hsa051311.23008115
85Starch and sucrose metabolism_Homo sapiens_hsa005001.22995749
86Bile secretion_Homo sapiens_hsa049761.22562794
87One carbon pool by folate_Homo sapiens_hsa006701.22327934
88Acute myeloid leukemia_Homo sapiens_hsa052211.21843753
89African trypanosomiasis_Homo sapiens_hsa051431.15748575
90Fat digestion and absorption_Homo sapiens_hsa049751.14158819
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12423812
92Hepatitis C_Homo sapiens_hsa051601.11843898
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09075564
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08786145
95Bladder cancer_Homo sapiens_hsa052191.08207762
96Chemokine signaling pathway_Homo sapiens_hsa040621.04001829
97Epstein-Barr virus infection_Homo sapiens_hsa051691.03884715
98Arginine and proline metabolism_Homo sapiens_hsa003301.03864159
99ABC transporters_Homo sapiens_hsa020100.98074373
100Apoptosis_Homo sapiens_hsa042100.97925394
101Steroid biosynthesis_Homo sapiens_hsa001000.95052627
102Collecting duct acid secretion_Homo sapiens_hsa049660.94239003
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93766069
104Vitamin digestion and absorption_Homo sapiens_hsa049770.93362912
105Pentose phosphate pathway_Homo sapiens_hsa000300.92880821
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92592971
107Hepatitis B_Homo sapiens_hsa051610.89371276
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.88755784
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83765564
110Glutathione metabolism_Homo sapiens_hsa004800.82223041
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78502385
112Ribosome_Homo sapiens_hsa030100.75125528
113Vibrio cholerae infection_Homo sapiens_hsa051100.73973405
114Metabolic pathways_Homo sapiens_hsa011000.68321164
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67209897
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64461982
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63333698
118Pyrimidine metabolism_Homo sapiens_hsa002400.62792955
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62290274
120VEGF signaling pathway_Homo sapiens_hsa043700.61251318
121T cell receptor signaling pathway_Homo sapiens_hsa046600.60529051
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.60490264
123Endocytosis_Homo sapiens_hsa041440.55798256
124Galactose metabolism_Homo sapiens_hsa000520.55540253
125Base excision repair_Homo sapiens_hsa034100.51670611
126Viral carcinogenesis_Homo sapiens_hsa052030.51652446
127HTLV-I infection_Homo sapiens_hsa051660.51650382
128Glycerolipid metabolism_Homo sapiens_hsa005610.50595019
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50449865
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.49700163
131Proteasome_Homo sapiens_hsa030500.48485015
132Lysine degradation_Homo sapiens_hsa003100.48482503
133Pancreatic cancer_Homo sapiens_hsa052120.48279765
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42182609
135Fructose and mannose metabolism_Homo sapiens_hsa000510.41701899
136Chronic myeloid leukemia_Homo sapiens_hsa052200.39028254
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.37822641
138Sphingolipid metabolism_Homo sapiens_hsa006000.35921596
139Non-small cell lung cancer_Homo sapiens_hsa052230.34005580
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33589099
141Amoebiasis_Homo sapiens_hsa051460.33415464
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32166605
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.31966524
144Notch signaling pathway_Homo sapiens_hsa043300.31500079
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30900290
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30299656
147RNA polymerase_Homo sapiens_hsa030200.27524313
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24176343
149Prion diseases_Homo sapiens_hsa050200.22836182
150Linoleic acid metabolism_Homo sapiens_hsa005910.21771492
151Oxidative phosphorylation_Homo sapiens_hsa001900.21703734
152Prolactin signaling pathway_Homo sapiens_hsa049170.19226421
153HIF-1 signaling pathway_Homo sapiens_hsa040660.17703696
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.17631903
155Synaptic vesicle cycle_Homo sapiens_hsa047210.17568435
156Fatty acid biosynthesis_Homo sapiens_hsa000610.17347695
157Protein export_Homo sapiens_hsa030600.15981474
158Parkinsons disease_Homo sapiens_hsa050120.15870975
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15561491
160Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.11316244
161Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11272759
162Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.10665697
163DNA replication_Homo sapiens_hsa030300.10516448
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.09847389
165Purine metabolism_Homo sapiens_hsa002300.09748478
166Regulation of autophagy_Homo sapiens_hsa041400.02271214
167Arachidonic acid metabolism_Homo sapiens_hsa005900.01752026
168Insulin resistance_Homo sapiens_hsa049310.00971423
169Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0935504
170Glucagon signaling pathway_Homo sapiens_hsa04922-0.0741709
171Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0636348
172Alzheimers disease_Homo sapiens_hsa05010-0.0541475
173Huntingtons disease_Homo sapiens_hsa05016-0.0457797
174N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0349224
175Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0145981

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