SCOCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1necroptotic process (GO:0070266)7.03547259
2NIK/NF-kappaB signaling (GO:0038061)6.90259504
3regulation of protein polyubiquitination (GO:1902914)6.26706903
4necrotic cell death (GO:0070265)6.24282143
5peroxisome fission (GO:0016559)6.11277282
6negative regulation of peptidyl-serine phosphorylation (GO:0033137)6.03047467
7mitochondrial fission (GO:0000266)5.86497037
8positive regulation of growth hormone secretion (GO:0060124)5.82455319
9regulation of female gonad development (GO:2000194)5.50715828
10mitochondrial fragmentation involved in apoptotic process (GO:0043653)5.46088715
11positive regulation of mitochondrial fission (GO:0090141)5.23474551
12regulation of growth hormone secretion (GO:0060123)5.10754452
13negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.97473806
14regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.90691891
15regulation of necroptotic process (GO:0060544)4.90453575
16positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.79652605
17regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.79652605
18programmed necrotic cell death (GO:0097300)4.72424029
19purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.72246501
20negative regulation of neurotransmitter secretion (GO:0046929)4.51415232
21negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.46105662
22negative regulation of T-helper cell differentiation (GO:0045623)4.46105662
23regulation of glycogen (starch) synthase activity (GO:2000465)4.42476942
24N-acetylglucosamine metabolic process (GO:0006044)4.39437161
25protein localization to Golgi apparatus (GO:0034067)4.39380603
26regulation of RIG-I signaling pathway (GO:0039535)4.26423925
27cullin deneddylation (GO:0010388)4.16570311
28retinal cone cell development (GO:0046549)4.15551925
29chondrocyte development (GO:0002063)4.07891866
30purine deoxyribonucleotide metabolic process (GO:0009151)4.05004443
31glycoprotein catabolic process (GO:0006516)4.02711682
32inositol metabolic process (GO:0006020)4.00636672
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.93347952
34regulation of mitochondrial fission (GO:0090140)3.81382226
35chemokine-mediated signaling pathway (GO:0070098)3.79526672
36positive regulation of vasculogenesis (GO:2001214)3.77081056
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63895910
38sperm-egg recognition (GO:0035036)3.55461988
39post-embryonic morphogenesis (GO:0009886)3.55072427
40regulation of memory T cell differentiation (GO:0043380)3.54817285
41pyrimidine nucleobase catabolic process (GO:0006208)3.54290865
42fat-soluble vitamin biosynthetic process (GO:0042362)3.53396245
43positive regulation of phosphatase activity (GO:0010922)3.49228989
44centriole replication (GO:0007099)3.46833475
45protein deneddylation (GO:0000338)3.46076046
46ADP metabolic process (GO:0046031)3.45425687
47regulation of MHC class I biosynthetic process (GO:0045343)3.44931277
48deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.40845282
49mitochondrion morphogenesis (GO:0070584)3.37983648
50negative regulation of neurotransmitter transport (GO:0051589)3.30021663
51natural killer cell activation involved in immune response (GO:0002323)3.29224514
52C4-dicarboxylate transport (GO:0015740)3.17111689
53protein K11-linked deubiquitination (GO:0035871)3.14071576
54adenosine metabolic process (GO:0046085)3.13715091
55regulation of T-helper 2 cell differentiation (GO:0045628)3.11373827
56positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.10874438
57negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.09035642
58head development (GO:0060322)3.08414424
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.08322837
60negative regulation of alpha-beta T cell differentiation (GO:0046639)3.05446958
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04166875
62regulation of axon regeneration (GO:0048679)3.02747407
63regulation of neuron projection regeneration (GO:0070570)3.02747407
64bone trabecula formation (GO:0060346)3.02390183
65regulation of DNA endoreduplication (GO:0032875)3.01657084
66protein localization to peroxisome (GO:0072662)3.00591836
67protein targeting to peroxisome (GO:0006625)3.00591836
68establishment of protein localization to peroxisome (GO:0072663)3.00591836
69dendritic spine morphogenesis (GO:0060997)2.99539237
70negative regulation of necroptotic process (GO:0060546)2.99334565
71regulation of T-helper 1 cell differentiation (GO:0045625)2.99222827
72body morphogenesis (GO:0010171)2.99178144
73binding of sperm to zona pellucida (GO:0007339)2.98436953
74pyrimidine dimer repair (GO:0006290)2.97740989
75centrosome duplication (GO:0051298)2.96112447
76L-serine transport (GO:0015825)2.95377417
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93863023
78regulation of protein glycosylation (GO:0060049)2.92956119
79cell-cell recognition (GO:0009988)2.90775726
80DNA double-strand break processing (GO:0000729)2.90223302
81negative regulation by host of viral transcription (GO:0043922)2.88913712
82neural tube formation (GO:0001841)2.85894725
83myoblast migration (GO:0051451)2.82322603
84nucleobase catabolic process (GO:0046113)2.80633662
85monoubiquitinated protein deubiquitination (GO:0035520)2.73351387
86central nervous system projection neuron axonogenesis (GO:0021952)2.70239437
87cell wall macromolecule catabolic process (GO:0016998)2.69185311
88hair cell differentiation (GO:0035315)2.68791323
89adipose tissue development (GO:0060612)2.66812360
90multicellular organism reproduction (GO:0032504)2.66135604
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.66114949
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65798843
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65764432
94positive regulation of T cell cytokine production (GO:0002726)2.65170594
95microtubule anchoring (GO:0034453)2.62410704
96polyol biosynthetic process (GO:0046173)2.60557269
97stress granule assembly (GO:0034063)2.59840143
98regulation of collateral sprouting (GO:0048670)2.59431644
99negative regulation of interleukin-10 production (GO:0032693)2.59348946
100glucosamine-containing compound metabolic process (GO:1901071)2.58873621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.78900460
2IGF1R_20145208_ChIP-Seq_DFB_Human4.58683833
3ZNF274_21170338_ChIP-Seq_K562_Hela3.37179203
4VDR_22108803_ChIP-Seq_LS180_Human3.01387325
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00778842
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.96070271
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.91833332
8GBX2_23144817_ChIP-Seq_PC3_Human2.88976037
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64839566
10TAF15_26573619_Chip-Seq_HEK293_Human2.41097024
11FUS_26573619_Chip-Seq_HEK293_Human2.21792045
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.21777893
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.17264202
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16203178
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.14861838
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99142712
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95378628
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88215594
19AR_25329375_ChIP-Seq_VCAP_Human1.88065029
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88032965
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.86069749
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84849569
23SMAD4_21799915_ChIP-Seq_A2780_Human1.83920854
24KLF5_20875108_ChIP-Seq_MESCs_Mouse1.83623092
25FOXA1_21572438_ChIP-Seq_LNCaP_Human1.80587566
26P300_19829295_ChIP-Seq_ESCs_Human1.80076988
27EWS_26573619_Chip-Seq_HEK293_Human1.77692198
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74145818
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73539315
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71747575
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70219239
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67592837
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.59847271
34GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.59274361
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58696293
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52804144
37PRDM14_20953172_ChIP-Seq_ESCs_Human1.46997206
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46983825
39RXR_22108803_ChIP-Seq_LS180_Human1.46384571
40STAT3_23295773_ChIP-Seq_U87_Human1.45727709
41ELK1_19687146_ChIP-ChIP_HELA_Human1.45077098
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42101798
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41920546
44KDM2B_26808549_Chip-Seq_REH_Human1.40251024
45TCF4_23295773_ChIP-Seq_U87_Human1.38572361
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36966383
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35561236
48CBP_20019798_ChIP-Seq_JUKART_Human1.35561236
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.34913566
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34913566
51RUNX2_22187159_ChIP-Seq_PCA_Human1.33895418
52EZH2_22144423_ChIP-Seq_EOC_Human1.29212363
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.29011124
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.28363259
55SALL4_22934838_ChIP-ChIP_CD34+_Human1.27265378
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26720862
57ER_23166858_ChIP-Seq_MCF-7_Human1.26010464
58VDR_24787735_ChIP-Seq_THP-1_Human1.25464099
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24312589
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18612777
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18122486
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17452974
63TCF4_22108803_ChIP-Seq_LS180_Human1.17218969
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17044094
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16169365
66JUN_21703547_ChIP-Seq_K562_Human1.14658729
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.14522091
68IRF1_19129219_ChIP-ChIP_H3396_Human1.11369348
69RUNX_20019798_ChIP-Seq_JUKART_Human1.10319583
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.10222773
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09435296
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.09251263
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06308140
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03892428
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.01974172
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.01896947
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01816200
78CDX2_22108803_ChIP-Seq_LS180_Human1.01404547
79AR_19668381_ChIP-Seq_PC3_Human1.01099601
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00039571
81SOX2_19829295_ChIP-Seq_ESCs_Human0.99289878
82NANOG_19829295_ChIP-Seq_ESCs_Human0.99289878
83CRX_20693478_ChIP-Seq_RETINA_Mouse0.99027920
84FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99006205
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99000250
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97477052
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96967677
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96617374
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96059891
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.96008591
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95098178
92BCAT_22108803_ChIP-Seq_LS180_Human0.94240925
93P53_22387025_ChIP-Seq_ESCs_Mouse0.93193853
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93122796
95STAT3_18555785_ChIP-Seq_MESCs_Mouse0.93085294
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92468451
97RNF2_27304074_Chip-Seq_NSC_Mouse0.92218374
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91823073
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91674410
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91083854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.92943353
2MP0003123_paternal_imprinting4.47615743
3MP0002837_dystrophic_cardiac_calcinosis4.16669352
4MP0002234_abnormal_pharynx_morphology4.13669453
5MP0003806_abnormal_nucleotide_metabolis3.74058411
6MP0008877_abnormal_DNA_methylation3.22015950
7MP0001188_hyperpigmentation3.05595953
8MP0003718_maternal_effect2.70734664
9MP0003787_abnormal_imprinting2.50654516
10MP0003890_abnormal_embryonic-extraembry2.45269100
11MP0003122_maternal_imprinting2.36761405
12MP0002876_abnormal_thyroid_physiology2.28280953
13MP0003121_genomic_imprinting2.17606338
14MP0005266_abnormal_metabolism2.10317707
15MP0001177_atelectasis1.93891439
16MP0001764_abnormal_homeostasis1.86237300
17MP0002332_abnormal_exercise_endurance1.80377592
18MP0005408_hypopigmentation1.73192100
19MP0004084_abnormal_cardiac_muscle1.70319964
20MP0001501_abnormal_sleep_pattern1.69448034
21MP0005410_abnormal_fertilization1.68821483
22MP0001545_abnormal_hematopoietic_system1.67889325
23MP0005397_hematopoietic_system_phenotyp1.67889325
24MP0003195_calcinosis1.65036400
25MP0001529_abnormal_vocalization1.59736104
26MP0005423_abnormal_somatic_nervous1.54860411
27MP0003868_abnormal_feces_composition1.48661172
28MP0005551_abnormal_eye_electrophysiolog1.44511378
29MP0000750_abnormal_muscle_regeneration1.41131274
30MP0005376_homeostasis/metabolism_phenot1.39866536
31MP0009278_abnormal_bone_marrow1.39417003
32MP0003880_abnormal_central_pattern1.37659516
33MP0002736_abnormal_nociception_after1.36270464
34MP0004043_abnormal_pH_regulation1.35021401
35MP0004130_abnormal_muscle_cell1.34177149
36MP0001191_abnormal_skin_condition1.33306528
37MP0003119_abnormal_digestive_system1.27772005
38MP0004085_abnormal_heartbeat1.24138261
39MP0002127_abnormal_cardiovascular_syste1.23444660
40MP0004883_abnormal_blood_vessel1.23092156
41MP0000778_abnormal_nervous_system1.22718307
42MP0003937_abnormal_limbs/digits/tail_de1.19363603
43MP0001968_abnormal_touch/_nociception1.16784857
44MP0005167_abnormal_blood-brain_barrier1.12978972
45MP0003646_muscle_fatigue1.12109525
46MP0002184_abnormal_innervation1.11720415
47MP0002272_abnormal_nervous_system1.11665719
48MP0005253_abnormal_eye_physiology1.11080049
49MP0000631_abnormal_neuroendocrine_gland1.08818689
50MP0008775_abnormal_heart_ventricle1.06153031
51MP0004811_abnormal_neuron_physiology1.04097646
52MP0001986_abnormal_taste_sensitivity1.04095534
53MP0006276_abnormal_autonomic_nervous1.04054788
54MP0008789_abnormal_olfactory_epithelium1.03068913
55MP0005075_abnormal_melanosome_morpholog1.00106180
56MP0002233_abnormal_nose_morphology0.99876211
57MP0003448_altered_tumor_morphology0.96537447
58MP0004742_abnormal_vestibular_system0.96345329
59MP0008058_abnormal_DNA_repair0.95524366
60MP0006035_abnormal_mitochondrial_morpho0.94963082
61MP0002254_reproductive_system_inflammat0.94251777
62MP0001486_abnormal_startle_reflex0.92585765
63MP0000569_abnormal_digit_pigmentation0.90604866
64MP0009250_abnormal_appendicular_skeleto0.89546484
65MP0006292_abnormal_olfactory_placode0.89413193
66MP0002971_abnormal_brown_adipose0.89331327
67MP0004142_abnormal_muscle_tone0.86675119
68MP0002396_abnormal_hematopoietic_system0.86067567
69MP0002638_abnormal_pupillary_reflex0.85890005
70MP0006072_abnormal_retinal_apoptosis0.84534059
71MP0003635_abnormal_synaptic_transmissio0.84153688
72MP0002734_abnormal_mechanical_nocicepti0.82713637
73MP0003755_abnormal_palate_morphology0.79902621
74MP0010155_abnormal_intestine_physiology0.79451022
75MP0000372_irregular_coat_pigmentation0.79164137
76MP0006036_abnormal_mitochondrial_physio0.78986801
77MP0002177_abnormal_outer_ear0.78619044
78MP0002138_abnormal_hepatobiliary_system0.78092449
79MP0000049_abnormal_middle_ear0.77260518
80MP0009115_abnormal_fat_cell0.76936597
81MP0005535_abnormal_body_temperature0.76022143
82MP0004885_abnormal_endolymph0.74825137
83MP0009745_abnormal_behavioral_response0.73332112
84MP0001293_anophthalmia0.72618317
85MP0010329_abnormal_lipoprotein_level0.72618305
86MP0000681_abnormal_thyroid_gland0.72474982
87MP0005395_other_phenotype0.71757299
88MP0005310_abnormal_salivary_gland0.71562274
89MP0005084_abnormal_gallbladder_morpholo0.71253175
90MP0003943_abnormal_hepatobiliary_system0.71110389
91MP0001970_abnormal_pain_threshold0.69287558
92MP0002938_white_spotting0.68741243
93MP0003385_abnormal_body_wall0.67339307
94MP0001299_abnormal_eye_distance/0.65641089
95MP0005645_abnormal_hypothalamus_physiol0.65261570
96MP0002277_abnormal_respiratory_mucosa0.62046493
97MP0002133_abnormal_respiratory_system0.61865526
98MP0005388_respiratory_system_phenotype0.61865526
99MP0002557_abnormal_social/conspecific_i0.59525066
100MP0004133_heterotaxia0.59266344

Predicted human phenotypes

RankGene SetZ-score
1Neonatal respiratory distress (HP:0002643)5.94447835
2Central scotoma (HP:0000603)3.64822373
3Limb hypertonia (HP:0002509)3.63313924
4Abnormality of the phalanges of the 2nd finger (HP:0009541)3.60197199
5Metaphyseal dysplasia (HP:0100255)3.53317451
6Abnormality of the costochondral junction (HP:0000919)3.36563153
7Attenuation of retinal blood vessels (HP:0007843)3.24280890
8Submucous cleft hard palate (HP:0000176)3.21730105
9Abnormality of the pubic bones (HP:0003172)3.13680205
10Hyperglycinemia (HP:0002154)3.04256120
11Thickened helices (HP:0000391)3.02900138
12Decreased central vision (HP:0007663)3.00899784
13Progressive microcephaly (HP:0000253)2.96224335
14Papillary thyroid carcinoma (HP:0002895)2.89769652
15Horizontal nystagmus (HP:0000666)2.76121002
16Small hand (HP:0200055)2.75837817
17Abnormality of macular pigmentation (HP:0008002)2.74599878
18Absent speech (HP:0001344)2.73657615
19Thickened nuchal skin fold (HP:0000474)2.72534279
20Broad alveolar ridges (HP:0000187)2.65787553
21Brushfield spots (HP:0001088)2.65768367
22Drooling (HP:0002307)2.65064296
23Bilateral sensorineural hearing impairment (HP:0008619)2.64702483
24Pancreatic fibrosis (HP:0100732)2.53026184
25Partial agenesis of the corpus callosum (HP:0001338)2.51207435
26Enlarged epiphyses (HP:0010580)2.50463951
27Abnormality of B cell number (HP:0010975)2.47255878
28Long foot (HP:0001833)2.45599203
29Excessive salivation (HP:0003781)2.44822159
30Abnormality of methionine metabolism (HP:0010901)2.44371424
31Hyperglycinuria (HP:0003108)2.41609356
32Curly hair (HP:0002212)2.39342111
33Short foot (HP:0001773)2.37710621
34Pachygyria (HP:0001302)2.37588307
35Hepatoblastoma (HP:0002884)2.35807875
36Thin bony cortex (HP:0002753)2.33005956
37CNS hypomyelination (HP:0003429)2.31814720
38Lissencephaly (HP:0001339)2.29580819
39Stomach cancer (HP:0012126)2.28191142
40Scotoma (HP:0000575)2.27768241
41Chronic hepatic failure (HP:0100626)2.26565113
42Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.25078075
43Barrel-shaped chest (HP:0001552)2.23193014
44Medial flaring of the eyebrow (HP:0010747)2.20946985
45Congenital stationary night blindness (HP:0007642)2.19840969
46Metaphyseal irregularity (HP:0003025)2.19572040
47Deep palmar crease (HP:0006191)2.17584166
48Absent frontal sinuses (HP:0002688)2.17316654
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16747167
50Cavernous hemangioma (HP:0001048)2.14062306
51Oligodactyly (hands) (HP:0001180)2.14037636
52Hypoplastic iliac wings (HP:0002866)2.13404701
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12842650
54Nephrogenic diabetes insipidus (HP:0009806)2.12685064
55Death in infancy (HP:0001522)2.11284326
56Flat occiput (HP:0005469)2.09601386
57Pendular nystagmus (HP:0012043)2.09552872
58Intestinal atresia (HP:0011100)2.09451000
59Abnormal epiphyseal ossification (HP:0010656)2.09234772
60Pancreatic cysts (HP:0001737)2.06147571
61Alveolar cell carcinoma (HP:0006519)2.05257402
62Pancreatic islet-cell hyperplasia (HP:0004510)2.03821180
63Abnormality of the fovea (HP:0000493)2.01713516
64Congenital primary aphakia (HP:0007707)2.01497925
65Abnormality of serine family amino acid metabolism (HP:0010894)2.00112448
66Abnormality of glycine metabolism (HP:0010895)2.00112448
67Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.98778027
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98617426
69Gaze-evoked nystagmus (HP:0000640)1.97141916
70B lymphocytopenia (HP:0010976)1.95946785
71Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95338518
72Gait imbalance (HP:0002141)1.94632902
73Volvulus (HP:0002580)1.90737734
74Widely patent fontanelles and sutures (HP:0004492)1.90619352
75Ankyloglossia (HP:0010296)1.88162843
76Abnormal rod and cone electroretinograms (HP:0008323)1.87686055
77Irregular epiphyses (HP:0010582)1.87482967
78Absent eyebrow (HP:0002223)1.85730942
79Aqueductal stenosis (HP:0002410)1.85600868
80Thickened calvaria (HP:0002684)1.84464635
81Abnormality of the periventricular white matter (HP:0002518)1.84190476
82Coronal craniosynostosis (HP:0004440)1.82053227
83Long clavicles (HP:0000890)1.81438692
84Patellar aplasia (HP:0006443)1.79863379
85Aplasia/Hypoplasia of the patella (HP:0006498)1.79214057
86Deep philtrum (HP:0002002)1.79077835
87Abnormality of the 2nd finger (HP:0004100)1.79048078
88Abnormality of the intrinsic pathway (HP:0010989)1.79032355
89Neoplasm of the tracheobronchial system (HP:0100552)1.78877179
90Clonus (HP:0002169)1.76721351
91Optic nerve hypoplasia (HP:0000609)1.75841070
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.75156945
93Absent/shortened dynein arms (HP:0200106)1.75156945
94Abnormality of the phalanges of the 5th finger (HP:0004213)1.74919873
95Severe muscular hypotonia (HP:0006829)1.74776171
96Broad foot (HP:0001769)1.73518203
97Erythroderma (HP:0001019)1.72488988
98Fair hair (HP:0002286)1.71435665
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71045535
100Heterotopia (HP:0002282)1.70242511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.08724436
2PDK24.71802026
3CASK4.52230828
4FRK4.05704049
5TRIM283.71579854
6WNK33.54285872
7MAP3K43.33300778
8CDC73.10223138
9MAP2K72.71352849
10MARK12.47621289
11PRKD32.24456942
12BRAF2.20336138
13PAK31.79371505
14ADRBK21.67054069
15SGK21.59267453
16BMPR1B1.58215403
17MAP2K41.52765831
18ZAK1.25735091
19EIF2AK31.20744534
20MAP4K21.16090088
21CDK31.11752012
22FLT31.11702855
23RIPK41.03975469
24ACVR1B1.02796656
25NUAK11.01352565
26SGK30.97942415
27SGK4940.97583867
28SGK2230.97583867
29TAF10.95410423
30DAPK20.93249415
31BCR0.91007473
32BLK0.85355284
33PIK3CG0.85062284
34PINK10.84620988
35TNIK0.84002220
36MUSK0.82245537
37MKNK20.77675537
38STK38L0.77148019
39TNK20.75686775
40TGFBR10.75475093
41EPHA30.72966702
42INSRR0.72387708
43MAPK130.70387160
44MINK10.68710133
45RPS6KA40.64231742
46PRKCE0.63152738
47CLK10.56234252
48CAMKK20.53744037
49PRKCI0.51207044
50MKNK10.49710265
51EPHA40.47952314
52DYRK30.47325881
53PRKG10.47001547
54BRD40.46695480
55DYRK1A0.46341958
56PRKAA10.46332045
57BMPR20.44331379
58WNK40.43001778
59CDK50.42667563
60PLK20.42526153
61RPS6KA50.42329684
62KIT0.41433606
63ADRBK10.41292620
64NEK60.40887569
65TEC0.40799766
66CAMK40.39511290
67HCK0.38618411
68ERBB30.36905299
69OBSCN0.36874558
70CSNK1D0.36115663
71FER0.36073756
72ATM0.35820225
73ATR0.35722371
74TAOK30.34411619
75PRKACA0.34153910
76CHEK10.33682989
77NLK0.33020323
78MAP3K70.32617483
79NEK10.32183250
80PRKG20.29767714
81PRKACG0.29696594
82AKT20.26803327
83PTK2B0.26251307
84SIK30.25371625
85MAPK70.25101239
86EPHB10.25040113
87MAPK90.24893037
88TAOK10.24739168
89PRKAA20.23788683
90ICK0.23698134
91CSNK1G10.23337018
92PRKDC0.23211915
93PRKCZ0.23101020
94GRK10.22905732
95AKT10.22526439
96MAP2K20.22289787
97MAPK10.21832320
98PKN10.20215097
99CSF1R0.20069546
100PRKCH0.19944628

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.29871503
2Sulfur metabolism_Homo sapiens_hsa009204.23945999
3Non-homologous end-joining_Homo sapiens_hsa034504.08927884
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.24362033
5Selenocompound metabolism_Homo sapiens_hsa004502.78417155
6Butanoate metabolism_Homo sapiens_hsa006502.77940970
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71841199
8Basal transcription factors_Homo sapiens_hsa030222.69081792
9Sphingolipid metabolism_Homo sapiens_hsa006002.63786714
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20626848
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96765666
12Tryptophan metabolism_Homo sapiens_hsa003801.92989917
13Taste transduction_Homo sapiens_hsa047421.83424870
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82942727
15Glycerolipid metabolism_Homo sapiens_hsa005611.74781778
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71902148
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55361613
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52777453
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50314498
20Linoleic acid metabolism_Homo sapiens_hsa005911.45170939
21Fatty acid metabolism_Homo sapiens_hsa012121.31488555
22Fat digestion and absorption_Homo sapiens_hsa049751.30660512
23Nicotine addiction_Homo sapiens_hsa050331.28032867
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26523771
25Olfactory transduction_Homo sapiens_hsa047401.25926100
26Propanoate metabolism_Homo sapiens_hsa006401.25866589
27Ether lipid metabolism_Homo sapiens_hsa005651.25814180
28Insulin secretion_Homo sapiens_hsa049111.25259644
29Phototransduction_Homo sapiens_hsa047441.23504245
30Protein export_Homo sapiens_hsa030601.21777149
31Sphingolipid signaling pathway_Homo sapiens_hsa040711.19199846
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14042208
33Morphine addiction_Homo sapiens_hsa050321.07313393
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05986240
35GABAergic synapse_Homo sapiens_hsa047271.04184738
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.03652498
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03166361
38Inositol phosphate metabolism_Homo sapiens_hsa005621.02289203
39Colorectal cancer_Homo sapiens_hsa052100.97891960
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97691839
41Fatty acid degradation_Homo sapiens_hsa000710.95542934
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94360746
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91378629
44Base excision repair_Homo sapiens_hsa034100.91148706
45Fatty acid biosynthesis_Homo sapiens_hsa000610.88241124
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87035167
47Chemokine signaling pathway_Homo sapiens_hsa040620.86899396
48Homologous recombination_Homo sapiens_hsa034400.86710019
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84439896
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82892825
51Circadian entrainment_Homo sapiens_hsa047130.82314540
52Insulin resistance_Homo sapiens_hsa049310.79202116
53TNF signaling pathway_Homo sapiens_hsa046680.77423685
54Serotonergic synapse_Homo sapiens_hsa047260.76758711
55Shigellosis_Homo sapiens_hsa051310.76564436
56Nitrogen metabolism_Homo sapiens_hsa009100.75605943
57p53 signaling pathway_Homo sapiens_hsa041150.74987687
58Calcium signaling pathway_Homo sapiens_hsa040200.71619271
59Cocaine addiction_Homo sapiens_hsa050300.69328685
60Dopaminergic synapse_Homo sapiens_hsa047280.61308959
61Amphetamine addiction_Homo sapiens_hsa050310.61048484
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.60139036
63Glutamatergic synapse_Homo sapiens_hsa047240.58955835
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58532803
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55978894
66Thyroid hormone synthesis_Homo sapiens_hsa049180.55894620
67RNA polymerase_Homo sapiens_hsa030200.55060498
68Caffeine metabolism_Homo sapiens_hsa002320.52716773
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.51751375
70African trypanosomiasis_Homo sapiens_hsa051430.49181793
71Purine metabolism_Homo sapiens_hsa002300.48688840
72Melanoma_Homo sapiens_hsa052180.47410864
73Axon guidance_Homo sapiens_hsa043600.47325095
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46056958
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41083975
76Pyrimidine metabolism_Homo sapiens_hsa002400.40550510
77Ovarian steroidogenesis_Homo sapiens_hsa049130.38739926
78Long-term depression_Homo sapiens_hsa047300.38530200
79Metabolic pathways_Homo sapiens_hsa011000.38143383
80cAMP signaling pathway_Homo sapiens_hsa040240.38023103
81Arachidonic acid metabolism_Homo sapiens_hsa005900.36708824
82Alcoholism_Homo sapiens_hsa050340.36372446
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36207880
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36119818
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35306348
86Circadian rhythm_Homo sapiens_hsa047100.33690729
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31961602
88Arginine and proline metabolism_Homo sapiens_hsa003300.31817446
89Bile secretion_Homo sapiens_hsa049760.29169456
90FoxO signaling pathway_Homo sapiens_hsa040680.28736442
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.27404443
92Pancreatic secretion_Homo sapiens_hsa049720.26603951
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26122945
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.25579783
95beta-Alanine metabolism_Homo sapiens_hsa004100.25277656
96Cholinergic synapse_Homo sapiens_hsa047250.24503115
97Nucleotide excision repair_Homo sapiens_hsa034200.24059050
98Salivary secretion_Homo sapiens_hsa049700.23296311
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22387466
100Glucagon signaling pathway_Homo sapiens_hsa049220.22032637

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